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Articles de revues sur le sujet "338.8/8"
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Abbasi, S., et A. Honaramooz. « 305 OPTIMIZING DONOR AND RECIPIENT FACTORS IN XENOGRAFTING OF TESTIS TISSUE ». Reproduction, Fertility and Development 22, no 1 (2010) : 308. http://dx.doi.org/10.1071/rdv22n1ab305.
Texte intégralRésumé :
Grafting of donor mammalian testis tissue into recipient mice allows completion of spermatogenesis in the grafted tissue and therefore can serve as a new option for preservation of male germ line. For testis tissue xenografting, castrated male nude mice typically serve as recipients, each receiving 8 testis tissue fragments; however, no study has comprehensively investigated donor and recipient factors. The objective of this study was to determine the effects of strain of immunodeficient recipient mouse (nude v. SCID), gonadal status (intact v. gonadectomized), and gender (male v. female) on the outcome of testis tissue xenografting. A secondary objective was to determine the optimal number of testis tissue fragments per mouse most suitable for xenografting. Testis parenchyma from newborn piglets were cut into small fragments (5 mg each) and grafted under the back skin of different groups of immunodeficient mice. In Experiment 1, 8 groups of mice (n = 7/group) served as recipients: castrated male nude, intact male nude, ovariectomized female nude, intact female nude, castrated male SCID, intact male SCID, ovariectomized female SCID, and intact female SCID. In Experiment 2, 4 groups of mice (n = 10/group) served as recipients of 2, 4, 8, or 16 testis tissue fragments per mouse. Recipient mice were sacrificed 8 months after grafting and the weight of the grafts and vesicular glands (male mice) were compared among groups by analysis of variance. In Experiment 1, mouse gonadal status (intact v. gonadectomized) did not affect the total graft weight (P > 0.05), but both the recipient mouse strain (nude v. SCID) and gender (male v. female) affected the total graft weight (2460 ± 320.9, 1420 ± 290.0, 758 ± 156.7, and 2780 ± 297.4, mean ± SEM, P < 0.0001 for SCID, nude, female, and male mice, respectively). In Experiment 2, the total graft weight was highest in the group of mice receiving 8 testis tissue fragments (192 ± 76.1, 695 ± 96.5, 2443 ± 338.8, and 1458 ± 305.4, mean ± SEM, P < 0.0001 for 2, 4, 8, or 16 fragment groups, respectively). These results collectively indicate that male SCID mice receiving 8 testis tissue fragments provide optimized conditions for the recovery of largest grafts. Research was supported by grants from the Natural Sciences and Engineering Research Council of Canada (NSERC) and the Saskatchewan Health Research Foundation (SHRF) to A. Honaramooz and scholarships from the Western College of Veterinary Medicine and the International Peace Scholarship to S. Abbasi.
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Salwa, Dian Fatimatus, Nurjaya, Muhammad Yusuf Wibowo, Dwi Prasojo et Nisrina Hasna’ Nabil. « Bioethanol Production from Breadnut (Artocarpus Camansi) Rind Waste as a Sustainable Energy Source ». IOP Conference Series : Earth and Environmental Science 1105, no 1 (1 décembre 2022) : 012010. http://dx.doi.org/10.1088/1755-1315/1105/1/012010.
Texte intégralRésumé :
Abstract Global energy consumption of fossil fuels which is expected to rise by about 177 quadrillion British thermal units (BTU). The scarcity of oil and fossil fuels along with the demand for energy needs can be overcome by switching to renewable and environmentally friendly energy. Biofuels can be an alternative energy and provide a clean green environment. Breadfruit peel waste is high in carbohydrates and sugar so have potential to be optimized into bioethanol. This research aims to determine the effect of variations in yeast mass and fermentation time on the bioethanol content of breadfruit rind through the distillation process. This study applies the fermentation method with variations (PI: 8 grams 72 hours), (P2: 10 grams 72 hours), (P3: 8 grams 96 hours), and (P4: 10 grams 96 hours). Then, the ethanol content was tested with Perkin Elmer Clarus 580 (GC) Perkin Elmer HS Turbo Matrix 40 (headspace sampler). The optimum results were found in the variation of yeast mass of 8 grams and fermentation time of 96 hours, with the resulting ethanol content of 339.8 mg/L at simplo and 338.08 mg/L at the time of duplication or an average of 338.94 mg/L.
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Casoinic, F., D. Sampelean, Anca D. Buzoianu, N. Hancu et Dorina Baston. « Serum Levels of Oxidative Stress Markers in Patients with Type 2 Diabetes Mellitus and Non-alcoholic Steatohepatitis ». Romanian Journal of Internal Medicine 54, no 4 (1 décembre 2016) : 228–36. http://dx.doi.org/10.1515/rjim-2016-0035.
Texte intégralRésumé :
Abstract Introduction. Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls. Materials and methods. In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study. The serum levels of protein carbonyls and 8-isoprostane were determined by ELISA methods, while the serum levels of malondialdehyde (MDA) were detected by means of the spectrophotometric method. Clinical, demographic, and laboratory parameters were examined for all the subjects included in the study. Multivariate logistic regression was used to test the independent predictive factors in the relationships investigated here. Results. Patients with DMT2 and NASH displayed significantly higher serum levels of protein carbonyls (1.112 ± 0.42 nmol/dL), MDA (6.181 ± 1.81 ng/mL), and 8-isoprostane (338.6 ± 98.5 pg/mL) compared to patients with DMT2 without NAFLD, and controls. Results of multivariate logistic regression analyses indicate that in patients with DMT2 and NASH, the serum levels of oxidative stress markers were independently and positively associated with: HbA1c, duration of diabetes, the UKPDS cardiovascular risk score (for protein carbonyls); age, LDL-cholesterol (for 8-isoprostane); and triglycerides serum levels (for MDA). Conclusions. Our findings indicate that the process of oxidative stress tends to increase in patients with DMT2 and NASH, compared to patients with DMT2 without NAFLD, and controls. This evidence suggests that an antioxidant therapy might prove useful in the treatment of patients with DMT2 and NASH.
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Manohar, Murli, Thomas E. Goetz, Beth Saupe, Elizabeth Hutchens et Elizabeth Coney. « Thyroid, renal, and splanchnic circulation in horses at rest and during short-term exercise ». American Journal of Veterinary Research 56, no 10 (1 octobre 1995) : 1356–61. http://dx.doi.org/10.2460/ajvr.1995.56.10.1356.
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SUMMARY Using radionuclide-labeled 15-μm-diameter microspheres injected into the left ventricle, we examined blood flow to the thyroid gland, adrenal glands, kidneys, and various gastrointestinal tract tissues in 9 healthy horses while they were standing quietly (rest) and during exercise at 2 work intensities (8 and 13 m/s). Hemodynamic measurements were made during steady-state conditions, as judged by the stability of heart rate as well as aortic, pulmonary, and right atrial pressures. The similarity of blood flow values for the left and the right kidneys during each of the 3 conditions indicated adequate mixing of microspheres with blood. In standing horses, of all tissues examined, the thyroid gland had the highest blood flow (1,655.2 ± 338.5 ml/min/100 g)—being about threefold that in the kidneys. Adrenal blood flow, by contrast, was only 25% of that in the kidneys (589.5 ± 50.4 ml/min/100 g). Among the gastrointestinal tract tissues, glandular stomach and pancreas had the highest blood flows (214.3 ± 21.6 and 197.6 ± 23.4 ml/min/100 g, respectively). Small intestinal perfusion was not different from that in the ventral colon and cecum, but their values exceeded those for the dorsal and small colons. Exercise at 8 and 13 m/s caused significant increase in adrenal blood flow as vascular resistance decreased significantly. In the kidneys, blood flow was only insignificantly affected during exercise at 8 m/s, but at 13 m/s there was a profound reduction in renal blood flow as intense renal vasoconstriction occurred. Vasoconstriction also caused thyroid and pancreatic blood flow to decrease significantly at both levels of exertion. Significant vasoconstriction occurring in all gastrointestional tract tissues at 8 and 13 m/s caused blood flow to be diverted away from these vascular beds. Thus, our data indicated that renal, adrenal, and splanchnic organ/tissue blood flow responses of strenuously exercising horses closely resemble those described for exercising ponies.
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Ling, C. D., R. L. Withers, A. D. Rae, S. Schmid et J. G. Thompson. « Antiferroelectric modulations in Sb2WO6 and Sb2MoO6 ». Acta Crystallographica Section B Structural Science 52, no 4 (1 août 1996) : 610–15. http://dx.doi.org/10.1107/s0108768196003813.
Texte intégralRésumé :
The structure of Sb2WO6 [Mr = 523.4, triclinic, F{\bar 1}, a = 11.132 (1), b = 9.896 (4), c = 18.482 (7) Å, α = 90.20 (4), β 96.87 (8), γ = 90.21 (5)°, Dx = 6.88 g cm−3, Z = 16, Mo Kα, λ = 0.7107 Å, μ = 338.5 cm−1, F(000) = 3536] has been refined as an enlarged 2a × 2b × 2c F-centred superstructure of the previously reported structure [Castro, Millan, Enjalbert, Snoeck & Galy (1994). Mat. Res. Bull. 29, 871–879] refined in the space group P1. The re-refinement follows the observation, initially by TEM, of satellite reflections at G± ½(111)*, where G represents a reflection of the P1 reciprocal lattice. A final value of 0.040 for R 1 = Σ h ||F obs(h)| − |F calc(h)||/Σ h ||F obs(h)| was obtained for 3316 merged reflections with I(h) > 3σ[I(h)], compared with R 1 = 0.12 for the previous refinement. The refined structure is described in terms of an antiferroelectric modulation of a P121/a1 underlying parent structure in the original setting. Twinning of the crystal was successfully modelled in the refinement. Synthesis of the previously unknown phase Sb2MoO6 [Mr = 435.5, triclinic, F{\bar 1}, a = 10.758 (1), b = 9.673 (2), c = 17.57 (1) Å, α = 90.00 (5), β = 96.98 (3), γ = 90.05 (2)°, Z = 16, Dx = 4.97 g cm−3] is also reported, along with evidence for its isostructuralism with Sb2WO6.
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Andrýs, Ctirad, Oldřich Pozler, Jan Krejsek, Václav Derner, Marcela Drahošová et Otakar Kopecký. « Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1 and sE-Selectin) in Healthy School Aged Children and Adults ». Acta Medica (Hradec Kralove, Czech Republic) 43, no 3 (2000) : 103–6. http://dx.doi.org/10.14712/18059694.2019.121.
Texte intégralRésumé :
The aim of this study was to map normal levels of serum soluble isoforms of adhesion molecules in relation to age and sex in the group of school-aged children. sICAM-1, sVCAM-1 and sE-selectin were determined in the group of 158 normal children subdivided into two subgroups; 6-10 years (68 children, median age 8 years) and 11-15 years (90 children, median age 12 years) and in 70 normal adult blood donors (25 females and 45 males, median age 46 years). The levels of sICAM-1 and sE-selectin fell down significantly over the age range 6-15 years, while the level of sVCAM-1 was remained. Age-related normal ranges were established using correlation analysis and were expressed as the 5%-95% percentiles intervals: sICAM-1 206.8-486.8 ng/ml, sE-selectin 36.7-153.2 ng/ml in the group of 6-10 years old children, sICAM-1 184.1-354.0 ng/ml, sE-selectin 29.9-114.1 ng/ml in group of 11-15 years old children. The levels of sVCAM-1 were 359.6-822.0 ng/ml and were constant within the examined age interval from 6 to 15 years. The influence of sex was also assayed and it was not statistically significant in any age category tested. Normal ranges of sICAM-1 (60.2-218.4 ng/ml), sE-selectin (8.3-116.9 ng/ml) and sVCAM-1 (338.0-1148.0 ng/ml) were established for adult population of healthy blood donors using the same methods.
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Moraes, Mariana Jucá, Erick Fonseca de Castilho, Júlio Cesar de Carvalho Balieiro, Alberto Carlos de Campos Bernardi, Andréa do Nascimento Barreto, Lívia Ferreira Pinho, Giovanna Galhardo Ramos, Gabriela Novais Azevedo, Letícia Krügner Zanetti et Alexandre Rossetto Garcia. « Differences in the Behavioral Parameters of Young Zebu and Composite Bulls Kept on Non-Forested or in Integrated Crop–Livestock–Forestry Systems ». Animals 14, no 6 (19 mars 2024) : 944. http://dx.doi.org/10.3390/ani14060944.
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The behavior of ruminants can influence their productive efficiency. The aim of this study was to evaluate the behavior of young zebu and composite bulls kept in pasture production systems, either in a crop-livestock-forest integration or without afforestation. The work was carried out in São Carlos, Brazil (21°57′42″ S, 47°50′28″ W), in a high-altitude tropical climate, from March to July, 2022. Forty young bulls were evaluated, being 20 Nelore (Bos indicus) (342.5 ± 36.6 kg BW; 16.9 ± 1.8 months) and 20 Canchim (5/8 Bos taurus × 3/8 Bos indicus) (338.4 ± 39.8 kg BW; 19.1 ± 1.9 months), equally distributed in full-sun (FS) and integrated crop–livestock–forestry (ICLF) production systems. Behavior was monitored uninterruptedly by an acoustic sensor and accelerometer attached to a collar, and complemented by direct visual assessment, in two one-day campaigns per month. Serum cortisol concentration was assessed monthly. Statistical analyses were conducted using a general linear model at a 5% significance level (SAS, version 9.4). The ICLF system had a milder microclimate and favored thermal comfort. Natural shading influenced grazing, resting, and rumination time. The Canchim bulls were more active when moving and grazing (p < 0.05), even at the hottest times of the day. In turn, the Nelore bulls spent more time resting at all times (p < 0.001), which was shown to be an adaptive strategy in response to environmental stimuli. The Canchim bulls had a longer rumination time than the Nelore bulls (p < 0.001), due to their longer grazing time. The frequency of water and mineral mixture intake did not differ between genotypes, regardless of the production system (p > 0.05). There was no difference in the serum cortisol concentrations of the Nelore and Canchim bulls kept in FS or ICLF (p = 0.082). Thus, young bulls of the different genotypes showed different behaviors, regardless of whether they were kept on pasture without afforestation or in an integrated crop–livestock–forestry system.
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Viscuse, Paul Vincent, Miao Zhang, Jingjing Liu, Rebecca Slack Tidwell, Sumit Kumar Subudhi, Amado J. Zurita, Paul Gettys Corn et al. « Linking the Aggressive Variant Prostate Cancer (AVPC) molecular signature (-ms) to androgen indifference in a prospective clinical trial. » Journal of Clinical Oncology 38, no 6_suppl (20 février 2020) : 156. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.156.
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156 Background: AVPC are morphologically heterogeneous tumors that share clinical features with the rare, virulent, androgen-indifferent and platinum-sensitive, small cell histologic variant. The AVPC-ms is composed of ≥2 defects in TP53, RB1 and PTEN, is detectable in »30% of advanced prostate cancers and predicts for benefit from platinum combinations (Corn et al. Lancet Oncol, 2019). Preclinical studies link the AVPC-ms with androgen indifference, but a prospective clinical association with decreased sensitivity to androgen signaling inhibitors is lacking. Methods: In a phase II trial (NCT02703623), men with metastatic castration resistant prostate cancer (mCRPC) treated with abiraterone and apalutamide were classified at week 8 as having a ‘satisfactory’ decline in PSA (≥ 50% from baseline) and CTC (≤5/7.5mL) or ‘unsatisfactory’. Pretreatment biopsies were obtained for immunohistochemistry (IHC) for TP53, RB1 and PTEN and RNA sequencing. Results: 198 men were registered. 59 (31.5%) of 187 evaluable had ‘unsatisfactory’ marker declines. Age, race/ethnicity, and baseline ECOG, PSA and LDH were similar between the groups. Men in the ‘unsatisfactory’ group had higher median total alkaline phosphatase (120 vs. 86; p=0.002), bone-specific alkaline phosphatase (21 vs. 16; p=0.01), CTC (9 vs. 1; p<0.001), and urine n-telopeptides (338.5 vs 182.5; p=0.003) levels. Unsupervised clustering of RNA profiles from 45 tumor biopsies revealed two distinct clusters. The top enriched gene set (FDR q-val<0.000) included ‘epithelial mesenchymal transition’, ‘E2F targets’ and ‘G2M checkpoint’ genes in one (n=18) and ‘androgen response’ in another (n=27) cluster. Six (33.3%) and 9 (33.3%) of the samples respectively belonged to patients in the ‘unsatisfactory’ decline group. IHC and RNA sequencing of the remaining samples are ongoing. Conclusions: Signaling pathways associated with androgen indifference can be identified in the tumor biopsies of men with early mCRPC, prior to exposure to secondary androgen signaling inhibitors. Their association with the AVPC-ms and patient outcomes will be presented. If confirmed, these markers could be used to inform therapy selection. Clinical trial information: NCT02703623.
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Thorn, Ross L., et James S. Drouillard. « PSVI-5 Extruded blend of Nannochloropsis oculata microalgae and flaxseed and its effects on ruminal fermentation and nutrient digestion ». Journal of Animal Science 102, Supplement_2 (1 mai 2024) : 340–41. http://dx.doi.org/10.1093/jas/skae102.389.
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Abstract Omega-3 fatty acids are essential nutrients for mammals, and are required for cellular growth and synthesis of numerous cellular signaling molecules. NBO3 Technologies, LLC (Manhattan, KS) has developed an omega-3 supplement consisting of an extruded blend of flaxseed and Nannochloropsis oculata microalgae (GreatOplus; GOP). Our objective was to evaluate effects of GOP on dry matter intake (DMI), water intake (WI), ruminal metabolism, and apparent total tract nutrient disappearance in cannulated Holstein steers (n = 11; initial body weight 586.4 ± 49.7 kg). Treatments consisted of backgrounding diets (40% roughage, 60% concentrate) containing 0% (CON) or 10% GOP (dry basis). Feed and water intake were recorded using an Insentec Roughage and Water monitoring system (Hokofarm Group; Emmeloord, The Netherlands). Steers were utilized in a cross-over design with two 19-d periods. Each period consisted of a 15-d adaptation phase and a 4-d collection phase. Ruminal contents, duodenal digesta, and feces were collected at 8-h intervals for 4 d starting at 1000 h on d 16. The sampling schedule was advanced by 2 h with each subsequent sampling day, thus generating a 24-h profile at 2-h intervals post-feeding over the 4-d sampling phase. Titanium dioxide (15 g) was dispensed directly into the rumen of each steer 15 min before feeding and to estimate apparent ruminal flow and fecal excretion of nutrients. There was a Treatment X Day interaction for DMI (P < 0.001); DMI was greater for steers fed GOP some of the days during the adaptation phase compared with steers fed the control diet, but intakes were similar during the collection phase. Ruminal fluid pH, ruminal ammonia concentration, and WI were not affected by treatment (P > 0.10). As expected, ruminal outflows of total fatty acids (195.6 vs 338.1 g/d for CON and GOP, respectively) and α-linolenic acid (ALA; 1.6 vs 6.3 g/d, respectively) were greater for steers fed GOP compared with steers fed CON (P < 0.05); however, ruminal disappearance (i.e., biohydrogenation) of ALA was extensive, with only 8% and 4.7% of ALA intake exiting the rumen for CON and GOP, respectively. Apparent total tract digestion of organic matter was not impacted by diet (P > 0.20; 78.1 and 76.8% for CON and GOP, respectively). Supplementing an extruded blend of flaxseed and microalgae can effectively increase the amount of α-linolenic acid available for absorption in the small intestine, but overall recovery of dietary α-linolenic acid is relatively low due to extensive biohydrogenation by microbes within the rumen.
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Prokina, V. Е., А. А. Ansheles, A. V. Tarasov, A. S. Ametov et V. B. Sergienko. « The Role of Scintigraphy and Hybrid Single-Photon Emission Tomography in Comparison with Laboratory Data in a Comprehensive Examination of Patients with Secondary Hyperparathyroidism ». Journal of radiology and nuclear medicine 103, no 1-3 (7 juillet 2022) : 15–29. http://dx.doi.org/10.20862/0042-4676-2022-103-1-3-15-29.
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Objective: to estimate the possibilities and determine the diagnostic value of scintigraphy and single-photon emission computed tomography combined with computed tomography (SPECT/CT) in the assessment of the functional state of parathyroids in comparison with laboratory data in patients with secondary hyperparathyroidism (SHPT). Material and methods. The study consistently included 64 patients with the established diagnosis of SHPT due to the acquired vitamin D deficiency or with terminal chronic kidney disease (CKD), with the presence of ultrasound data and laboratory tests of calcium-phosphoric exchange indicators. Neck and mediastum nuclear study with 99mTc-methoxy-isobutyl-isonitrile (MIBI) was performed in the planar two-phase scintigraphy mode according to the standard protocol with an estimation of parathyroid visualization intensity, as well as in SPECT/CT performed 1 hour after MIBI injection. Results. In the group of patients with CKD as a cause of SHPT (n = 14), the most pronounced increase of parathyroid hormone (PTH) level (210.8 ± 103.0 vs. 107.0 ± 40.2 pg/ml in patients with vitamin D deficiency (n = 50, p < 0.001)) and phosphorus (mean 1.39 ± 0.51 mmol/l), as well as excess of normal levels of alkaline phosphatase (407.7 ± 338.1 units/l) were noted. In patients with vitamin D deficiency, impaired parathyroids according to SPECT/CT data was visualized in 8 % of cases, and in patients with CKD in 14.3 %. No significant differences in the mean levels of vitamin D in patients with (n = 46) and without (n = 4) modified parathyroids according to scintigraphy were detected: 26.06 ± 13.19 vs. 25.82 ± 18.80 ng/ml, respectively (p = 0.97). Differences in PTH and calcium levels were not observed: 91.3 ± 39.2 vs. 89.2 ± 29.5 pg/ml (p = 0.90), 2.53 ± 0.21 vs. 2.58 ± 0,15 mmol/l (p = 0.64), respectively. Conclusion. The neck SPECT/CT is a key method of topical imaging of impaired parathyroids in preoperative preparation of patients with SHPT caused by CKD. The method may have a diagnostic value in treatment-resistant patients with vitamin D deficiency and upper-normal PTH and calcium levels in terms of detection of the nodular form of parathyroid hyperplasia. The implementation of SPECT/CT after 1 hour after MIBI injection increases the sensitivity of the study.
Livres sur le sujet "338.8/8"
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Klein, Naomi. No logo : Taking aim at the brand bullies. Toronto : Knopf Canada, 2000.
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Klein, Naomi. No logo : geen ruimte, geen keuze, geen werk : De strijd tegen de dwang van de wereldmerken. De Geus, 2014.
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Klein, Naomi. No Logo - LA Tyrannie DES Marques (French Edition). Editions 84, 2007.
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Klein, Naomi. No Logo : No Space, No Choice, No Jobs. Picador, 2009.
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Klein, Naomi. No logo : El poder de las marcas. Booket, 2011.
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Klein, Naomi. No Logo. BUR Biblioteca Univerzale Rizzoli, 2010.
Trouver le texte intégralChapitres de livres sur le sujet "338.8/8"
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Haddas, R., A. Satin, D. Mar, I. Lieberman, A. Block, T. Belanger, M. Kayanja et RS Kakar. « The effect of scoliosis support orthosis bracing on adult spinal deformity patients : evaluation of gait and dynamic balance ». Dans Studies in Health Technology and Informatics. IOS Press, 2021. http://dx.doi.org/10.3233/shti210448.
Texte intégralRésumé :
Non-operative treatment is regarded as the first-line therapy for patients with adult spinal deformity (ASD) without neurologic deficits or significant impairment. While there is high-level evidence supporting the use of rigid bracing in adolescent idiopathic scoliosis, there is a paucity of literature pertaining to the use of scoliosis support orthosis (SSO) in ASD patients. To investigate the impact of an SSO on pain, gait parameters, and functional balance measures in symptomatic ASD patients. Thirty ASD patients (26 Females, Age: 72.7, Cobb Angle: 47.1°) were evaluated on 3 different occasions: first day of bracing: baseline (Pre), and 45-min post fitting (Post45m), and after 8-weeks of bracing for 4 hours a day (Post8w). Each patient performed a 6-minute walk (over-ground gait), a dynamic balance test, and completed VAS, ODI, and SRS22r. Significant short- and long-term improvements using SSO were found in the 6-minute walk (Pre: 278.6; Post45m: 322.2; Post8w: 338.8 m, p<0.001), walking speed (Pre: 0.88; Post45m: 0.97; Post8w: 0.97 m/s, p<0.001), head total sway distance during the balance test (Pre: 81.33; Post45m: 68.63; Post8w: 60.72 cm, p=0.048), low-back pain (VAS: Pre: 5.5; Post45m: 3.5; Post8w: 3.3, p<0.001), and for the ODI (Pre: 41.9; Post45m: 32.9; Post8w: 30.1, p=0.005).This study demonstrated clinically significant improvements in PROMs, spatiotemporal gait measures, and functional balance measures after continuous use of a SSO. These improvements were observed immediately following brace-fitting and maintained at an 8-week follow-up. Given these results, it is reasonable to consider a SSO for conservative management of patients with mild symptoms of pain and deformity, and who have not yet progressed to meet surgical indications.