Articles de revues : « 301-400 »

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Sari, Berliana, Kusuma Adhianto, Erwanto Erwanto et Ali Husni. « PRODUKTIVITAS SAPI BRAHMAN CROSS TIPE BULL DENGAN BOBOT AWAL YANG BERBEDA DI PT. INDO PRIMA BEEF LAMPUNG TENGAH, PROVINSI LAMPUNG ». Jurnal Riset dan Inovasi Peternakan (Journal of Research and Innovation of Animals) 8, n^o 2 (17 mai 2024) : 186–92. http://dx.doi.org/10.23960/jrip.2024.8.2.186-192.

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Penelitian ini bertujuan untuk mengetahui produktivitas sapi Brahman Cross tipe bull dengan bobot awal yang berbeda di PT. Indo Prima Beef Lampung Tengah, Provinsi Lampung. Penelitian ini dilaksanakan selama 3 bulan Januari-Maret di PT. Indo Prima Beef Lampung Tengah, Provinsi Lampung. Metode yang digunakan yaitu survei dengan pengambilan sampel populasi suatu data. Data yang digunakan adalah data sekunder dan primer. Data dianalisis dengan analisis deskriptif dan ditampilkan dalam bentuk diagram batang. Hasil penelitian menunjukkan bahwa Pertambahan Bobot Badan Harian (PBBH) tertinggi adalah sapi dengan bobot awal 351-400 kg sebesar 1,55kg/ekor/hari diikuti sapi bobot awal 301-350 kg sebesar 1,35kg/ekor/hari dan sapi bobot awal 250-300kg /ekor /hari. Feed Intake (FI) sapi tertinggi secara berurutan adalah sapi dengan bobot awal 351-400 kg sebanyak 14kg/ekor/hari, 301-350 kg sebanyak 11kg/ekor/hari dan 250-300 kg sebanyak 9,7kg/ekor/hari. Feed Conversion Ratio (FCR) sapi paling baik yang dihasilkan dalam penelitian ini secara berurutan adalah sapi dengan bobot awal 250-300 kg 8,0%, 301-350 kg 8,1% dan 351-400 kg 9,0%. Income Over Feed Cost (IOFC) sapi yang menghasilkan keuntungan paling tinggi secara berurutan adalah sapi Brahman Cross tipe bull dengan bobot awal 351-400 kg sebesar Rp. 221.047/ekor/hari, 301-350 kg sebesar Rp.208.645/ekor/hari dan 250-300 kg sebesar Rp. 178.072 /ekor /hari. Kesimpulan penelitian ini yaitu produktivitas sapi Brahman Cross tipe bull dengan bobot awal yang berbeda di PT. Indo Prima Beef yang terbaik adalah pada bobot 351-400 kg dibanding bobot 250-300 kg dan 301-350 kg.

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Goes, Elenice Souza dos Reis, Aldi Feiden, Dacley Hertes Neu, Marcio Douglas Goes, Wilson Rogério Boscolo et Altevir Signor. « RENDIMENTOS DO PROCESSAMENTO E COMPOSIÇÃO CENTESIMAL DE FILÉS DO JUNDIÁ Rhamdia voulezi ». Ciência Animal Brasileira 16, n^o 4 (décembre 2015) : 481–90. http://dx.doi.org/10.1590/1089-6891v16i421100.

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Resumo O objetivo deste trabalho foi avaliar o efeito do peso de abate e do sexo sobre os rendimentos do processamento e sobre a composição centesimal do jundiá (R. voulezi). Foram calculados os rendimentos percentuais em relação à massa do peixe inteiro (rendimentos da carcaça, tronco limpo, músculo abdominal, filé, partes comestíveis, cabeça, pele, gônadas e gordura visceral). Não houve diferença estatística nos rendimentos entre as classes (P>0,05). Entretanto, ao se avaliarem os rendimentos entre os sexos, foi observada diferença significativa (P<0,05) para os rendimentos da carcaça, tronco limpo, músculo abdominal e gordura visceral, sendo que os machos obtiveram os maiores valores nestes itens. As fêmeas apresentaram maior (P<0,05) rendimento das gônadas. Os teores de proteína bruta, cinzas e carboidratos não diferiram (P>0,05) entre as classes, porém, a umidade, lipídeos e valor calórico tiveram diferença significativa (P<0,05) entre as classes, sendo que a umidade diminuiu com o aumento do tamanho dos peixes e o teor de lipídeos e valor calórico foi maior nos peixes da classe 301-400 g. Concluiu-se que os rendimentos do processamento do jundiá (R. voulezi) com massa entre 100 e 400 g são iguais, sendo que os peixes de 301 a 400 g apresentam maior teor de lipídeos no filé.

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Wen, Shixue, et Jerzy A. Szpunar. « The Correlation of Texture and Microstructure to the Corrosion Resistance of Tin Coatings ». Materials Science Forum 495-497 (septembre 2005) : 1413–18. http://dx.doi.org/10.4028/www.scientific.net/msf.495-497.1413.

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The influence of current density and temperature on the macrotexture, the orientation and size of grains, and the corrosion resistance of tin deposits was studied. Tin coatings with two different textures, (100) and (301) fiber textures were produced by electrodeposition at 20°C by varying current density. At a lower current density of 100A/m2, (301) fibre was obtained. At the current densities of 100 and up to 400 A/m2, only (100) fibre texture was observed. An increase in current density leads to a decrease in grain size. At the same current density, the grain size of tin coatings increases with increased temperature. The influence of temperature (20, 40, 60 and 80 °C) on texture is relatively negligible. The corrosion resistance of tin coatings increases with a decrease in grain size. The corrosion resistance of tin coating with (301) fibre is higher than that of tin coating with (100) fibre texture. The results suggest that texture and microstructure play an important role in controlling corrosion rate of tin based coatings.

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Agarwal, Vipin K. « Liquid Chromatographic Determination of Vitamin D in Fortified Milk ». Journal of AOAC INTERNATIONAL 71, n^o 1 (1 janvier 1988) : 19–22. http://dx.doi.org/10.1093/jaoac/71.1.19.

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Abstract A method for the determination of vitamins D2 + D3 in fortified milk is described. Vitamins D2 and D3 are extracted from the saponified sample and converted to isotachysterols with antimony trichloride. The isotachysterols are quantitated using liquid chromatography with ultraviolet detection at 301 nm, which is the absorption maximum. At this wavelength other materials present in the sample do not interfere with the analysis of isotachysterols and therefore a cleanup step is avoided. Recoveries of vitamin D added to skim milk were 98.1% (SD 5.3), 96.7% (SD 3.3), and 96.0% (SD 5.1) for samples fortified with 200, 400, and 600 IU/quart, respectively. For whole milk, recoveries were 102.0% (SD 6.5) and 97.1% (SD 3.5) in samples fortified with vitamin D equivalent to 200 and 400 IU/quart, respectively. The detection limit for vitamin D is 40 IU/quart.

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Wolfer, Lina A., Judith Howard et Laureen M. Peters. « Accuracy of 1,2-o-Dilauryl-rac-glycero-3-glutaric Acid-(6′-methylresorufin) Ester (DGGR)-Lipase to Predict Canine Pancreas-Specific Lipase (cPL) and Diagnostic Accuracy of Both Tests for Canine Acute Pancreatitis ». Veterinary Sciences 9, n^o 4 (8 avril 2022) : 177. http://dx.doi.org/10.3390/vetsci9040177.

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Different lipase assays have variable reported diagnostic accuracies for acute pancreatitis (AP) in dogs. The aims of this retrospective study were to evaluate optimal cutoffs for 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6′-methylresorufin) ester (DGGR)-lipase to predict diagnostic cutoffs of canine pancreas-specific lipase (cPL; IDEXX). DGGR-lipase activity and cPL from the same blood draw in 301 dogs with a variety of diseases were compared using Spearman’s rank correlation, Cohen’s kappa agreement, and receiver operating characteristic (ROC) curves. Activity of DGGR-lipase (10–15,616 U/L) and cPL concentrations (8.1–≥2000 µg/L) were highly correlated (rs = 0.91). Areas under the ROC curves (AUCs) to predict cPL >200 and ≥400 µg/L with DGGR-lipase were 0.97 and 0.99, with optimal cutoffs of 143 U/L (sensitivity (Se) 91.7%; specificity (Sp) 95.3%) and 205 U/L (Se 97.5%; Sp 96.4%), and Cohen’s kappa agreements of 0.87 and 0.92, respectively. AUCs for a clinical diagnosis of AP, assigned to 87/301 dogs, with DGGR-lipase (0.75) and cPL (0.76) did not differ significantly (p = 0.48); optimal cutoffs were 161 U/L for DGGR (Se 67%; Sp 81%) and 235 µg/L for cPL (Se 68%; Sp 84%). To conclude, DGGR-lipase is a highly accurate predictor of cPL with a comparable performance when used to diagnose AP in dogs.

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Indrayani, Y., D. Setyawati, Y. Mariani, Y. Takematsu et T. Yoshimura. « Diversity of termite species at various altitudes in the secondary forest, West Kalimantan, Indonesia ». IOP Conference Series : Earth and Environmental Science 959, n^o 1 (1 janvier 2022) : 012014. http://dx.doi.org/10.1088/1755-1315/959/1/012014.

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Abstract Forests are the natural habitat for termite breeding, where the diversity of its species is higher than other habitats. Therefore, it is imperative to be knowledgeable about the diversity of termites to assess the function of their colonies in environmental ecosystems. An introductory survey to measure the diversity of termite species in a tropical forest in Kapuas Hulu Regency, West Kalimantan, Indonesia, was initiated from August – September 2020. This survey was carried out at various altitudes, namely 100 - 200, 201 - 300, and 301 - 400 masl. The termite sampling process was carried out on a 100 m path for each altitude. Observations were made in 8 plots, measuring 10 x 10 m. The termites were collected from the soil surface, leaf litters, mud trails, fallen logs, tree trunks, and roots, including termite nests. The chemical properties of the soil were analyzed to measure organic carbon, pH, nitrogen, phosphorus, and potassium. A total of 150 samples of termite were collected in the survey from 8 plots at an altitude of 100 – 200 masl (97 individuals), 5 plots at an altitude of 201 – 300 masl (43 individual) and 2 plots at an altitude of 301 - 400 masl (10 individuals). We found seven species of subterranean termites belonging to two families (Termitidae and Rhinotermitidae) and five sub-families (Macrotermitinae, Termitinae, Coptotermitinae, Nasutitermitinae, and Rhinotermitinae). Increasing altitude leads reduction in the number of species of individual termites. This reduced diversity of termite species in higher areas is due to decreased temperature because cold temperatures inhibit termite’s metabolic rate. Soil chemical analysis shows that C-Organic, N, P, K, and CEC contents in this study decreased with increasing altitude. In conclusion, we highlight that altitude is a limiting factor for the distribution of termite species. It is in direct proportion with the homogeneous distribution of termite species in secondary forests of Kapuas Hulu District, West Kalimantan, Indonesia, possibly due to a decrease in air temperature and soil mineral elements.

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Li, Linhua, Liangshun Xiang, Yan Lin, Lei Chen, Renqing Guo, Yiqi Cao, Xiaohua Huang et Jianbo Wu. « Li/Na Ion Storage Performance of a FeOF Nano Rod with Controllable Morphology ». Processes 10, n^o 8 (28 juillet 2022) : 1491. http://dx.doi.org/10.3390/pr10081491.

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Although the conversion material iron oxyfluoride (FeOF) possesses a high theoretical specific capacity as a cathode material for Li/Na ion batteries, its poor rate and cycling performances, caused mainly by sluggish (Li+/Na+) reaction kinetics, restrict its practical application. Herein, FeOF with high purity, a fusiform nanorod shape and high crystallinity is prepared through a facile chemical solution reaction. The electrochemical measurements show that the present FeOF exhibits high capacity and good cycling stability as a cathode material for Li-ion batteries. Capacities of 301, 274, 249, 222, and 194 mAh/g at stepwise current densities of 20, 50, 100, 200, and 400 mA/g are achieved, respectively. Additionally, the capacity at 100 mA/g retains 123 mAh/g after 140 cycles. Meanwhile, as a cathode material for Na ion battery, it delivers discharge capacities of 185, 167, 151, 134 and 115 mAh/g at stepwise current densities of 20, 50, 100, 200, and 400 mA/g, respectively. A discharge capacity of 83 mAh/g at 100 mA/g is achieved after 140 cycles. The excellent lithium/sodium-storage performance of the present FeOF material is ascribed to its unique nanostructure.

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Campagna, Sara, Alberto Borraccino, Gianfranco Politano, Marco Dalmasso, Aldo Ravaglia, Valerio Dimonte et Maria Michela Gianino. « Emergency-department accesses in home care paediatric patients : Occurrence and risks of use in a six-year retrospective investigation in Northern Italy ». PLOS ONE 16, n^o 12 (31 décembre 2021) : e0262085. http://dx.doi.org/10.1371/journal.pone.0262085.

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Objective To assess the determinants of ED use in paediatric patients enrolled in an Integrated Paediatric Home Care (IPHC) program. Methods A retrospective study was conducted using administrative databases on a cohort of patients enrolled in an IPHC program between January 1st, 2012, and December 31st, 2017, in Northern Italy. ED visits that occurred during the IPHC program were considered. Data were collected considering sociodemographic, clinical and organizational variables. A multivariable stepwise logistic regression analysis was performed. The dependent variable to identify possible associations was ED visit. Results A total of 463 ED visits occurred in 465 children, with an incidence rate of 1. The risk of ED visits significantly increased among children involved in the IPHC program after hospital discharge (OR 1.94). Additionally, the risk of ED visits increased significantly as the duration of IPHC increased (OR 5.80 between 101 and 200 days, to OR 7.84 between 201 and 300 days, OR 12.54 between 301 and 400 days and OR 18.67 to more than 400 days). Conclusion The overall results represent a practical perspective to contribute improving both the service quality of IPHC and reducing low acuity and improper ED use.

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Umboh, Iwan Sixtus. « Insect Diversity In Forest Of Mount Klabat, Kauditan Subdistrict North Minahasa Regency ». Indonesian Biodiversity Journal 1, n^o 1 (10 novembre 2020) : 14–21. http://dx.doi.org/10.53682/ibj.v1i1.141.

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This study aims to assess The population and insect diversity in the Forest of Klabat. Sequences of this study consisted of determining the location of the sample, the sample unit, and forest. This research was conducted using survey methods, identification, and analysis data. The resulting study showed that insect populations and diversity obtained from the forest of Klabat is a total of 190 individuals consisting of 29 orders and 23 families, with the amount of each individual as follows: 34 Diptera, Hymenoptera 25, 21 Coleoptera, Lepidoptera 18, .and Orthoptera 5. The population the highest of the forest that is on the order Diptera Family Lauxamidae. Insect Diversity in the forest of Klabat at altitude 301 -400 masl is H. =4,76, and in the forest of Klabat at altitude 401 – 500 masl is H. = 2,31.

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Brito, Roberta Lomonte Lemos de, Sandra Valéria Inácio, Dalilian Antoniete dos Santos Oliveira, Maximiana Mesquita de Sousa, Marcelo Vasconcelos Meireles, Raimundo Nonato Braga Lobo, Luiz da Silva Vieira et Katia Denise Saraiva Bresciani. « Ocorrência da infecção por Cryptosporidium spp. em cabritos (Capra hircus) ». Pesquisa Veterinária Brasileira 34, n^o 8 (août 2014) : 728–32. http://dx.doi.org/10.1590/s0100-736x2014000800003.

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O presente estudo teve como objetivo determinar a ocorrência da infecção por Cryptosporidium spp. em cabritos de Quixadá, Ceará, Brasil. Participaram do estudo 400 cabritos, com idade entre três e 360 dias, de ambos os sexos, com e sem padrão racial definido, procedentes de 25 estabelecimentos rurais distribuídos em três circuitos. As fezes foram cadastradas de acordo com o aspecto e cor, distribuídas em tubos tipo "eppendorf®" e congeladas in natura a -20°C, até o momento das extrações de DNA genômico do parasito com auxílio de kit comercial. Para amplificação de fragmentos da subunidade 18S do RNA ribossômico (rRNA) foi utilizada a "Nested"-PCR. A ocorrência de Cryptosporidium spp em cabritos de Quixadá foi de 7,50% (30/400). A frequência no período seco e no chuvoso foi de 9,55% (19/199) e 5,47% (11/201), respectivamente (χ²=2,39 e P>0,05). Amostras positivas foram identificadas em 64,00% (16/25) das propriedades estudadas e dessas amostras 50,00% (15/30) e 70,00% (21/30) tinham as fezes com aspecto e cor normais, respectivamente, sugerindo que cabritos assintomáticos estão eliminando oocistos. Não foi observada positividade para Cryptosporidium spp. em animais com 301 a 360 dias, demonstrando que animais mais velhos apresentam menos possibilidade de se infectarem com o parasito.

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Been, Sabrina K., David A. M. C. van de Vijver, Jannigje Smit, Nadine Bassant, Katalin Pogány, Sarah E. Stutterheim et Annelies Verbon. « Feasibility of Four Interventions to Improve Treatment Adherence in Migrants Living with HIV in The Netherlands ». Diagnostics 10, n^o 11 (20 novembre 2020) : 980. http://dx.doi.org/10.3390/diagnostics10110980.

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We evaluated the feasibility and efficacy of four existing interventions to improve adherence to them in migrants living with HIV (MLWH): directly administered antiretroviral therapy (DAART), group medical appointments (GMA), early detection and treatment of psychological distress, and peer support by trained MLWH. At baseline and after the interventions, socio-demographic characteristics, psychosocial variables, and data on HIV treatment adherence were collected. The two questionnaires were completed by 234/301 (78%) MLWH included at baseline. Detectable HIV RNA decreased (from 10.3 to 6.8%) as did internalized HIV-related stigma (from 15 to 14 points), and self-reported adherence increased (between 5.5 and 8.3%). DAART and GMA were not feasible interventions. Screening of psychological distress was feasible; however, follow-up diagnostic screening and linkage to psychiatric services were not. Peer support for and by MLWH was feasible. Within this small intervention group, results on HIV RNA < 400 copies/mL (decrease of 23.6%) and outpatient clinic attendance (up to 20.4% kept more appointments) were promising.

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Shen, Hui, Qihong Lou, Zhao Quan, Xuewen Li, Yifeng Yang, Xiaolong Chen, Qiurui Li et al. « Narrow-linewidth all-fiber amplifier with up to 301 kW output power based on commercial 20/400 μm active fiber and counterpumped configuration ». Applied Optics 58, n^o 12 (11 avril 2019) : 3053. http://dx.doi.org/10.1364/ao.58.003053.

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Nasser, Azmi, Joseph T. Hull, Fatima A. Chowdhry, Toyin Adewole, Tesfaye Liranso et Stefan Schwabe. « 112 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study (P302) : Efficacy and Safety of Extended-Release Viloxazine in Adolescents with ADHD ». CNS Spectrums 25, n^o 2 (avril 2020) : 272–73. http://dx.doi.org/10.1017/s1092852920000309.

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Abstract:Study Objective:SPN-812 (extended-release viloxazine) is a structurally distinct, bicyclic, Serotonin Norepinephrine Modulating Agent (SNMA) in development as a treatment for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This Phase 3, randomized, double-blind study (P302) evaluated the efficacy and safety of once-daily SPN-812 at doses of 200 and 400 mg compared to placebo in adolescents ages 12-17yrs with ADHD.Method:Inclusion criteria required subjects have a confirmed Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) ADHD diagnosis, ADHD-Rating Scale-5 (ADHD-RS-5) score ≥28, Clinical Global Impression-Severity score ≥4, and be free of ADHD medication ≥1 week before randomization. This investigation was conducted at 34 study sites in the United States. Subjects (N=310) were randomized 1:1:1 to placebo:200 mg SPN-812:400 mg SPN-812. The treatment period included up to 1 week of titration and 5 weeks of maintenance (intent-to-treat population: N=301; placebo=104, 200 mg=94, 400 mg=103). The primary efficacy endpoint was change from baseline (CFB) at end of study (EOS) in ADHD-RS-5 total score. Key secondary endpoints included Clinical Global Impression-Improvement (CGI-I) score at EOS, and CFB at EOS in Conners 3-Parent Short Form (Conners 3-PS) Composite T-score and Weiss Functional Impairment Rating Scale-Parent Form (WFIRS-P) total average score. Safety assessments included adverse events (AEs), laboratory tests, vital signs, physical exams, electrocardiograms, and the Columbia-Suicide Severity Rating Scale.Results:Compared to placebo, a significantly greater improvement in ADHD-RS-5 total score was observed in the 200 mg and 400 mg SPN-812 treatment group at EOS (p=0.0232, p=0.0091; respectively). Significant improvement in CGI-I score at EOS for both 200 mg and 400 mg SPN-812 compared to placebo was also observed (p=0.0042, p=0.0003; respectively). No significant change was observed at either dose compared to placebo in the Conners 3-PS Composite T-score (p=0.6854, p=0.0518; respectively), or the WFIRS-P total average score (p=0.2062, p=0.0519; respectively). The most common (≥5%) treatment-related AEs were somnolence, decreased appetite, fatigue, headache, and nausea.Conclusions:In this study, SPN-812 met the primary objective for both the 200 and 400 mg doses, and a key secondary objective (CGI-I) for both the 200 and 400 mg doses. AE-related dropouts were ≤5%, indicating SPN-812 treatment was well tolerated.This study is an encore of a poster presentation at the 2019 Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP).Funding Acknowledgements:This research was funded by Supernus Pharmaceuticals, Inc., Rockville, MD.

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Videnovic, Zivorad, Zoran Dumanovic, Milena Simic, Jelena Srdic, Milosav Babic et Vesna Dragicevic. « Genetic potential and maize production in Serbia ». Genetika 45, n^o 3 (2013) : 667–77. http://dx.doi.org/10.2298/gensr1303667v.

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Genetic potential of maize hybrids grown in Serbia is 10-15 t ha-1 , while the average yields are considerably lower. There are many reasons for this. At first, it is well known that drought is present often in some parts of country. Some soils are not suitable in the same degree for intensive maize production, application of mineral fertilizers is insufficient, mechanization is outdated and arable farms are small and fragmented. During the period 19652012 high variations in precipitation were present during the maize vegetation. The yearly average precipitation sum was 688.9 mm, with 397.5 mm during vegetation. According to precipitation amount, years were divided into groups: I 200-300 mm 7, (15%); II 301-400 mm 21, (44%) and III 401-500 mm 14, (30%), and IV in 5 years (11%) more than 500 mm of precipitation was present. The highest average yield in Serbia was achieved in 1991 (5.95 t ha-1) and the lowest in 2000 (2.44 t ha-1). The average yield increase was 114 kg ha-1 per year from 1965 to 1985, and it was 22 kg ha-1 per year from 1986 to 2012. In experiments during the period 1998-2012, when the standard cropping technology (MSY) was applied, the average grain yield was10.46 t ha-1 for hybrids of FAO 300-400, 10.39 t ha-1 for hybrids from FAO 500 and 11.38 for FAO 600-700. There were no significant differences in yield between hybrids from examined FAO groups. According to this, average maize yield includes only 44.2% for FAO 300-400, 44.5% for FAO 500 and 40.6% for FAO 600700 utilized maize genetic potential. The significant improvement of maize production demand the strategic long-term program, where it will be elaborated: merging of land properties, increasing of the areas with irrigation and increasing of the technology level in maize cropping.

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Thomas, Sajeve, Young Ki Hong, Yazan Samhouri, James Larkin, David J. Olson, Gino K. In, Victoria Atkinson et al. « Abstract CT286 : TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy in combination with pembrolizumab vs pembrolizumab alone in treatment-naive unresectable or metastatic melanoma ». Cancer Research 84, n^o 7_Supplement (5 avril 2024) : CT286. http://dx.doi.org/10.1158/1538-7445.am2024-ct286.

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Abstract Introduction: Novel early-line therapies for advanced (unresectable or metastatic) melanoma are needed to improve the rate of deep and durable responses and increase the proportion of patients with long-term benefit. TILVANCE-301 will evaluate the efficacy and safety of lifileucel autologous TIL cell therapy plus pembrolizumab in patients with untreated advanced melanoma. Methods: TILVANCE-301 (NCT05727904) is a phase 3, multicenter, randomized, open-label, parallel group study that will randomize ~670 patients (1:1; Day 0) to Arm A: lifileucel plus pembrolizumab (Day 3: tumor tissue resection for TIL manufacturing; Day 5: pembrolizumab 200 mg; Day 26: pembrolizumab 400 mg; Day 28-29: cyclophosphamide 60 mg/kg; Day 28-32: fludarabine 25 mg/m2; Day 33: lifileucel; Day 34-37: ≤6 doses of high-dose IL-2; Week 10: pembrolizumab 400 mg Q6W) or Arm B: pembrolizumab alone (same pembrolizumab dosing as Arm A). Patients in Arm B with confirmed progressive disease verified by blinded independent review committee (BIRC) have the option to receive lifileucel monotherapy as immediate next treatment and may continue pembrolizumab until start of nonmyeloablative lymphodepletion. Eligible adults have histologically confirmed advanced melanoma, Eastern Cooperative Oncology Group performance status of 0-1, estimated life expectancy >6 months, ≥1 resectable lesion to generate lifileucel, and ≥1 remaining measurable lesion. Prior neoadjuvant or adjuvant treatment including immune checkpoint inhibitors may be allowed. Prior therapy for metastatic disease, symptomatic untreated brain metastases, organ allograft or prior cell therapy, uveal/ocular melanoma, and chronic systemic steroid therapy are not permitted. The dual primary efficacy endpoints are BIRC-assessed (RECIST v1.1) objective response rate (ORR) and progression-free survival (PFS). Key secondary efficacy endpoint is overall survival. Additional secondary efficacy endpoints include BIRC-assessed complete response (CR) rate, duration of response (DOR), and event-free survival (EFS); investigator-assessed ORR, PFS, CR rate, DOR, EFS, and PFS2; and safety as characterized by severity and seriousness of treatment-emergent adverse events and relationship to study drug. Exploratory endpoints include in vivo T-cell persistence (unique CDR3 sequences in peripheral blood mononuclear cell [PBMC] over time) and correlative biomarkers (eg, lifileucel phenotypic and functional characteristics; lifileucel, tumor, and PBMC gene expression profiles; tumor mutational landscape). The study will enroll globally, with initial sites in Europe, North America, and Australia. Trial registration: NCT05727904 Citation Format: Sajeve Thomas, Young Ki Hong, Yazan Samhouri, James Larkin, David J. Olson, Gino K. In, Victoria Atkinson, Philip Lammers, Andrew J. Furness, Juan Martin-Liberal, Patrick Terheyden, Andrew S. Poklepovic, Ryan H. Nguyen, Idit Peretz, Marcus Butler, Adnan Khattak, Lavinia Spain, E.M. Gaughan, Melissa Wilson, John W. Dubay, Anja Williams, Stephanie Goff, Gary C. Doolittle, Jason Chesney, Friedrich Graf Finckenstein, Jeffrey Chou, Xiao Wu, Giri Sulur, Wen Shi, John Haanen. TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy in combination with pembrolizumab vs pembrolizumab alone in treatment-naive unresectable or metastatic melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT286.

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Nasser, Azmi, Joseph T. Hull, Fatima A. Chowdhry, Toyin Adewole, Tesfaye Liranso et Stefan Schwabe. « 113 Phase 3, Randomized, Double-Blind, Placebo-Controlled Study (P303) Assessing Efficacy and Safety of Extended-Release Viloxazine in Children with ADHD ». CNS Spectrums 25, n^o 2 (avril 2020) : 273–74. http://dx.doi.org/10.1017/s1092852920000310.

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Abstract:Study Objective:SPN-812 (extended-release viloxazine) is a structurally distinct, bicyclic, Serotonin Norepinephrine Modulating Agent (SNMA) in development as a treatment for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. This Phase 3, randomized, double-blind study (P303) evaluated the efficacy and safety of once-daily SPN-812 at doses of 200 and 400 mg compared to placebo in children ages 6-11yrs with ADHD.Method:Inclusion criteria required subjects have a confirmed Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) ADHD diagnosis, ADHD-Rating Scale-5 (ADHD-RS-5) score ≥28, Clinical Global Impression-Severity score ≥4, and be free of ADHD medication ≥1 week before randomization. Subjects were enrolled at 31 study sites in the United States. Subjects (N=313) were randomized 1:1:1 to placebo:200 mg SPN-812:400 mg SPN-812. Treatment included up to 3 weeks of titration and 5 weeks of maintenance (intent-to-treat population: N=301; placebo=97, 200 mg=107, 400 mg=97). The primary efficacy endpoint was change from baseline (CFB) at end of study (EOS) in ADHD-RS-5 total score. Key secondary endpoints included Clinical Global Impression-Improvement (CGI-I) score at EOS, and CFB at EOS in Conners 3-Parent Short Form (Conners 3-PS) Composite T-score and in Weiss Functional Impairment Rating Scale-Parent Form (WFIRS-P) total average score. Safety assessments included adverse events (AEs) among other measures.Results:Compared to placebo, a significantly greater improvement in ADHD-RS-5 total score was observed in the 200 mg and 400 mg SPN-812 treatment group at EOS (p=0.0038, p=0.0063; respectively). Significant improvement in CGI-I score at EOS for both 200 mg and 400 mg SPN-812 was also observed (p=0.0028, p=0.0099; respectively). Significant improvement was observed for the 200 mg SPN-812 dose compared to placebo in the Conners 3-PS Composite T-score (p=0.0064), but not for the 400 mg dose (p=0.0917). No significant improvement was observed in either dose group in the WFIRS-P total average score (p=0.0651, p=0.1680; respectively). The most common (≥5%) treatment-related AEs were somnolence, decreased appetite, fatigue, headache, and upper abdominal pain.Conclusions:In this study, SPN-812 met the primary objective for both the 200 and 400 mg doses and the key secondary objective (CGI-I) for both the 200 and 400 mg doses with statistical significance. A second key secondary objective (Conners 3-PS) for the 200 mg dose was also met. AE-related dropouts were ≤5%, indicating SPN-812 treatment was well tolerated.This study is an encore of a poster presentation at the 2019 Annual Meeting of the American Academy of Child and Adolescent Psychiatry (AACAP).Funding Acknowledgements:This research was funded by Supernus Pharmaceuticals, Inc., Rockville, MD.

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Stegniy, B., A. Gerilovych, S. Vilcek, E. Peterhans, R. Kucheriavenko, M. Stegniy, I. Goraichuk, V. Bolotin et O. Solodiankin. « Molecular Epidemiology Issues of BVDV Infection in the Eastern Ukraine ». Agricultural Science and Practice 1, n^o 1 (15 avril 2014) : 37–41. http://dx.doi.org/10.15407/agrisp1.01.037.

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Aim. This study was focused on (i) detection of specifi c BVDV-antibodies within selected cattle farms, (ii) identifi cation of persistently infected (PI) animals and (iii) genetic typing of selected BVDV isolates. Methods. RNA extraction, real-time polymerase chain reaction, ELISA technique, sequencing. Results. Specifi c BVDV- antibodies were detected in 713 of 1,059 analyzed samples (67.3 per cent). This number is in agreement with fi ndings in many cattle herds around the world. However, the number of positive samples differed in the herds. While 57 samples out of 283 (20.1 per cent) were identifi ed in the fi rst herd, 400 out of 475 (84.2 per cent) and 256 out of 301 (85 per cent) animals were positive in the second and third herd. High number of animals with BVDV RNA was detected in all herds. The real-time PCR assay detected BVDV RNA in 5 of 1068 samples analyzed (0.5 per cent). 4 positive samples out of 490 (0.8 per cent) and 1 out of 301 (0.33 per cent) were found in the second and third herd. The genetic materials of BVDV were not found in the fi rst herd. Data on the number of PI animals were in accord with serological fi ndings in the cattle herds involved in our study. The genetic typing of viral isolates revealed that only BVDV, Type 1 viruses were present. The phylogenetic analysis confi rmed two BVDV-1 subtypes, namely b and f and revealed that all 4 viruses from the second farm were typed as BVDV-1b and all of them were absolutely identical in 5’-UTR, but virus from the third farm was typed as BVDV-1f. Conclusion. Our results indicated that the BVDV infection is widespread in cattle herds in the eastern Ukraine, that requires further research and development of new approaches to improve the current situation.

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Arini, Tri, Latifa Hanum Lalasari, Iwan Setiawan, Lia Andriyah, Nadia Chrisayu Natasha, Fariza Eka Yunita et Ariyo Suharyanto. « STRUKTUR KRISTAL DAN MORFOLOGI PERMUKAAN – SINTESIS SNO2 MENGGUNAKAN METODE SOL-GEL ». Jurnal Rekayasa Mesin 13, n^o 2 (31 août 2022) : 427–33. http://dx.doi.org/10.21776/jrm.v13i2.1048.

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SnO2 oxide powder was synthesized using the sol-gel method. SnO2 oxide powder was produced using a solution of tin(IV) chloride (SnCl4) and 25% ammonia (NH4(OH)) by annealing the final product for 4 hours at 900 °C. The pH variation was carried out at pH 7 and 9. XRD analysis showed that the structure of SnO2 formed was polycrystalline with a tetragonal crystal structure with crystal planes (110), (101); (200), (111), (210), (211), (220), (002), (310), (112), (301), (202), (321), (400), (222 ), (330) wherein the crystal plane (110) has the predominant structure. The crystal size using the Scherrer formula, varied from 56,204 and 54,936 nm for pH values 7 and 9. The size using HSP analysis, in the (110) plane the values obtained were 561,594 and 543,901Å for pH 7 and 9. The crystal size decreased with increasing pH. Surface morphology was carried out by SEM analysis, obtained grain sizes of 71.5 and 62.32 nm at pH 7 and 9, respectively. The variation in pH mostly affected the size, shape, and morphology of SnO2.

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Souza, Maria Luiza Rodrigues de, Elisabete M. Macedo-Viegas et Sérgio do Nascimento Kronka. « Influência do método de filetagem e categorias de peso sobre rendimento de carcaça, filé e pele da tilápia do Nilo (Oreochromis niloticus) ». Revista Brasileira de Zootecnia 28, n^o 1 (février 1999) : 1–6. http://dx.doi.org/10.1590/s1516-35981999000100001.

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O objetivo deste trabalho foi avaliar o efeito do método de filetagem (F1= retirada da pele com alicate e filetagem; F2= filetagem e retirada da pele, com faca e auxílio de alicate) e a categoria de peso (P1=250-300 g; P2 =301-350 g; P3=351-400 g e P4= 401-450 g) sobre o rendimento de carcaça (RC), filé (RF) e pele da tilápia do Nilo. Foram utilizadas 48 tilápias, em delineamento inteiramente casualizado. Houve efeito para método de filetagem, sendo a média de F1 (56,43 e 36,67%) superior à de F2, 53,46 e 32,89%, respectivamente, para RC e RF. Para categoria de peso, as médias P1 (56,49 e 37,34%) e P2 (56,34 e 36,40%) foram superiores em relação a P3 (53,27 e 31,98%) e P4 (53,71 e 33,42%), respectivamente, para RC e RF. Porcentagens de pele bruta, limpa e de descarne foram superiores para F2, mas não houve efeito para as categorias de peso. A filetagem F1 proporcionou melhores rendimentos e resultados de pele e, para categoria de peso, P1 e P2, maiores rendimentos.

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Kurbanov, Yu K. « Distribution of the Notched fin eelpout Lycodes pectoralis (Zoarcidae) in the Northeastern Sea of Okhotsk during the Hydrological Summer ». Вопросы ихтиологии 63, n^o 1 (1 janvier 2023) : 31–38. http://dx.doi.org/10.31857/s0042875223010095.

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For the first time, the data are presented on the distribution and size composition of the notched fin eelpout Lycodes pectoralis in the northeastern part of the Sea of Okhotsk during the hydrological summer. Its densest aggregations are located on the continental slope of Kamchatka between 52° and 56° N and in the western part of the TINRO depression, in a local area 56°–57° N. The range of the vertical distribution of L. pectoralis covers depths from 199 to 653 m, and the temperature range in which this species occurs is 0–2.3°С. High frequency of occurrence, average density and biomass of the species are typical for depths of 301–400 and 401–500 m at a temperature of the near-bottom water of 1.0–2.0°С. Based on a critical analysis of the literature data and the fact that L. pectoralis is predominantly confined to the habitat in the waters of the unique intermediate water mass of the Sea of Okhotsk, it is suggested that the species is endemic to the Sea of Okhotsk.

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Lin, Chong, Hanxin Chen, Li Zeng, Shusen Wu et Xiaogang Fang. « Microstructures and Properties of V-Modified A380 Aluminum Alloy Produced by High Pressure Rheo-Squeeze Casting with Compound Field Treatment ». Metals 11, n^o 4 (3 avril 2021) : 587. http://dx.doi.org/10.3390/met11040587.

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The melt of V-modified A380 alloy aluminum alloy was treated by compound field of ultrasonic vibration (UV) and electromagnetic stirring (ES) around liquidus temperatures. Then the high pressure rheo-squeeze casting (HPRSC) process was used to produce an ingot with the alloy melt obtained. The results indicate that the polygonal Si2V phase is precipitated after adding vanadium to the alloy. With the increasing of V content from 0 to 1.05%, the average length and volume fraction of β-Al5FeSi phase is decreased to 30 μm and 1.44%, respectively. The refinement effects of UV, ES, and UV-ES compound field on the microstructure of the gravity casting alloy are as follows: UV-ES > UV > ES. When the pressure is increased from 0 to 400 MPa, the size of primary α-Al is decreased gradually, the morphology of β-Al5FeSi phase is changed from an acicular to a fine fibrous-like one, and the polygonal Si2V phase is refined to fine particle with an average grain diameter of about 8 μm. The ultimate tensile strength (UTS), yield strength (YS), and elongation of the alloy without V are lower than that of the alloy with 0.7% V under the same pressure. When the pressure is 400 MPa, the UTS, YS, and elongation of T6 heat-treated HPRSC alloy with 0.7% V are 301 MPa, 182 MPa, and 3.3%, respectively. With the decrease in the length of β-Al5FeSi phase, the quality index of the HPRSC alloy is increased.

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Wang, May, Katherine Heck, Marilyn Winkleby et Catherine Cubbin. « Social disparities in dietary habits among women : Geographic Research on Wellbeing (GROW) Study ». Public Health Nutrition 19, n^o 9 (17 novembre 2015) : 1666–73. http://dx.doi.org/10.1017/s1368980015003225.

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AbstractObjectiveRelationships among race/ethnicity, individual socio-economic status (SES), neighbourhood SES and acculturation are complex. We sought to answer whether: (i) race/ethnicity, individual SES and neighbourhood SES have independent effects on women’s fruit and vegetable consumption (FVC); (ii) SES modifies the effects of race/ethnicity on FVC; and (iii) nativity modifies the effect of Latina ethnicity on FVC.DesignCross-sectional surveys from the population-based Geographic Research on Wellbeing (GROW) Study were linked with census-tract level data. FVC was indicated by (i) consuming fruits and vegetables less often than daily (LOWFV) and (ii) not having fruits and vegetables in the home very often. Other variables included age, marital status, race/ethnicity, country of birth, educational attainment, family income and longitudinal neighbourhood poverty (based on latent class growth models). Weighted logistic regression models accounting for the complex sample design were constructed.SettingCalifornia, USA, 2012–2013.SubjectsWomen (n 2669).ResultsIn adjusted models, race/ethnicity, education and income were independently associated with FVC, but not neighbourhood poverty. Women of colour, high-school graduates and women with incomes at 301–400 % of the federal poverty level were at higher odds of LOWFV compared with non-Hispanic Whites, college graduates and those with incomes >400 % of the federal poverty level. Little evidence for interactions between race/ethnicity and individual or neighbourhood SES was found; similar patterns were observed for immigrant and US-born Latinas.ConclusionsAddressing the dietary needs of lower-SES communities requires multilevel interventions that simultaneously provide culturally tailored nutrition education and address the physical and economic accessibility of culturally acceptable fruits and vegetables.

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Hirsch, Fred R., Marileila Varella-Garcia, Paul A. Bunn, Michael V. Di Maria, Robert Veve, Roy M. Bremnes, Anna E. Barón, Chan Zeng et Wilbur A. Franklin. « Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas : Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis ». Journal of Clinical Oncology 21, n^o 20 (15 octobre 2003) : 3798–807. http://dx.doi.org/10.1200/jco.2003.11.069.

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Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. The molecular mechanisms responsible for EGFR overexpression are poorly understood. Materials and Methods: Gene copy number and protein status of EGFR were investigated in microarrayed tumors from 183 NSCLC patients, including squamous cell carcinoma (SCC; 89 patients) and non-SCC (94 patients) histologies. Protein expression was assessed by immunohistochemistry on a scale from 0 to 400 (percentage of positive cells × staining intensity). Gene and chromosome 7 copy numbers were identified by fluorescent in situ hybridization (FISH). Results: EGFR protein overexpression was observed in 62% of the NSCLC (25% scored 201 to 300; 37% scored 301 to 400), more frequently in SCC than non-SCC (82% v 44%; P < .001), and in 80% of the bronchioloalveolar carcinomas. The prevalent FISH patterns were balanced disomy (40%) and trisomy (38%) for EGFR gene and chromosome 7 (40%), whereas balanced polysomy was seen in 13% and gene amplification was seen in 9% of the patients. Gene copy number correlated with protein expression (r = 0.4; P < .001). EGFR overexpression or high gene copy numbers had no significant influence on prognosis. Conclusion: EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. It will be important to evaluate EGFR gene and EGFR protein status and signal protein expression to properly interpret future clinical trials using EGFR inhibitors.

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Vogel, Arndt, Tim Meyer, Eric Assenat, Mariona Calvo Campos, Songzi Li, Yaxi Chen, Frederic Boisserie, Ramil Abdrashitov, Donatella Marino et Richard S. Finn. « Tislelizumab (TIS) versus sorafenib (SOR) in first-line (1L) treatment of unresectable hepatocellular carcinoma (HCC) : The RATIONALE-301 European/North American (EU/NA) subgroup. » Journal of Clinical Oncology 41, n^o 16_suppl (1 juin 2023) : 4082. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.4082.

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4082 Background: HCC is one of the most commonly diagnosed cancers globally. Most cases occur in Asia, although a number of patients (pts) are affected in Europe and North America. In the phase 3, open-label RATIONALE-301 trial (NCT03412773), TIS, a PD-1 inhibitor, showed non-inferior overall survival (OS) versus SOR (hazard ratio 0.85, 95% CI: 0.71, 1.02), and a favorable safety profile, in 1L treatment of pts with unresectable HCC. Here, efficacy and safety of TIS versus SOR in the RATIONALE-301 EU/NA subgroup were compared with the overall population (OP). Methods: Systemic therapy-naïve adults with histologically confirmed HCC were randomized (1:1) to receive TIS (200 mg IV Q3W) or SOR (400 mg orally BID) until disease progression, intolerable toxicity, or withdrawal. The primary endpoint was OS; secondary endpoints included objective response rate (ORR), progression-free survival (PFS), and duration of response (DoR) by blinded independent review committee per RECIST v1.1, and safety. Results: In the EU/NA subgroup (172/674 pts randomized), at data cutoff (July 11, 2022), median (m) OS follow-up was 37.9 months (mo) (TIS) vs 38.5 mo (SOR). At baseline, fewer pts in the EU/NA subgroup had Barcelona Clinic Liver Cancer (BCLC) Stage C disease (70% vs 78%) and extrahepatic spread (51% vs 62%), and more had a non-viral etiology (60% vs 24%) or underlying HCV infection (28% vs 13%) than in the OP, respectively. Distribution of other baseline characteristics was generally similar between the EU/NA subgroup and the OP. Efficacy data in the EU/NA subgroup were consistent with the OP. Numerically longer mOS and mDoR, higher ORR, and similar mPFS were observed with TIS versus SOR in the EU/NA subgroup. In the EU/NA safety population, incidence of ≥grade 3 treatment-emergent adverse events (TEAEs; 46% vs 66%), ≥grade 3 treatment-related TEAEs (TRAEs; 17% vs 50%), and TRAEs leading to discontinuation (9% vs 15%) was lower with TIS versus SOR, respectively, similar to the OP. Conclusions: In the RATIONALE-301 EU/NA subgroup, mOS of TIS was non-inferior versus SOR, consistent with the findings from the OP. Numerically longer mOS and mDoR, and a higher ORR was seen with TIS versus SOR in the EU/NA subgroup, which had a higher rate of pts with non-viral etiology and a slightly lower number of pts with advanced-stage disease (BCLC Stage C) compared with the OP. Clinical trial information: NCT03412773 . [Table: see text]

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Herman, B., et F. Mandel. « Is Speed of Onset of Anti-anxiety Efficacy with Pregabalin Influenced by Starting Dose ? » European Psychiatry 24, S1 (janvier 2009) : 1. http://dx.doi.org/10.1016/s0924-9338(09)70762-x.

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Objective:There appears to be no dose-response effect for pregabalin at doses of 300-600 mg, and a modest dose-response effect in the range of 150-300 mg. The goal of the current investigation was to determine the effect of the starting dose on the speed of onset of anxiolytic efficacy.Methods:Data were analyzed from 7 trials of outpatients with DSM-IV GAD and a HAM-A total score ≥18. Starting doses of pregabalin ranged from 100 mg (N=301) or 150 mg (N=104), to 200 mg (N=167) and 300 mg (N=388). Assessment of early improvement included the HAM-A total score and CGI-Severity and Improvement scores.Results:The mean Week 1 HAM-A change score was similar for a starting dose of 200 mg/d with no titration (-8.24) when compared to patients who started on 200 mg/d and then titrated up to 400 mg/d on Day 4 (-8.64). The mean Week 1 HAM-A change score was somewhat higher for patients started on 300 mg/d, and then titrated to 450 mg/d on Day 4/5 (-8.84) when compared to patients started on a lower (100/150 mg/d) dose and titrated on Day 5 to 400/450 mg/d (-7.32). Starting on a dose of 300 mg/d with no titration resulted in an intermediate Week 1 change score (-7.87). The interaction of starting dose and titration schedule with baseline anxiety severity will be summarized in detail.Conclusion:The initial dose of pregabalin appears to have only a weak effect on the speed of onset of anxiolytic improvement.

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Nam, Moon-hee, et Hyeon-jeom Heo. « Effect of Nurses' Work-Life Balance and Nursing Performance on Happiness Index ». Korean Data Analysis Society 24, n^o 6 (30 décembre 2022) : 2329–42. http://dx.doi.org/10.37727/jkdas.2022.24.6.2329.

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The purpose of this study was to prepare a plan to increase the happiness index of nurses by identifying the work-life balance, nursing performance, and happiness index of clinical nurses. The subjects of this study were 161 hospital nurses located in B metropolitan city and K province through self-questionnaires from May 6 to May 20, 2022. The collected data were analyzed using SPSS/Win 24.0. As a result of the analysis, the work-life balance perceived by nurses was 3.29 points (out of 5 points), nursing performance was 3.73 points (out of 5 points), and the happiness index was 3.37 points (out of 5 points). The difference in happiness index according to general characteristics differed according to male (t=3.608, p<.001), current department (F=3.271 p=.023), and monthly average salary (F=4.068 p=.019). There was a significant difference, and the happiness index of nurses had a significant positive correlation between work-life balance (r=.591, p<.001) and nursing performance (r=.396, p<.001). As a result of analyzing the factors affecting the happiness index of nurses, work-life balance (β=.48, p<.001), salary level of 400 ten thousand won or more (β=.24, p=.01), 301-400 ten thousand won (β=.23, p=.03), nursing performance (β=.20, p<.001), and male (β=.14, p=.03) were significant variables. The explanatory power of the variable was 40.7%. In conclusion, in order to increase the happiness index of nurses, it is necessary to improve policies that increase the happiness index by improving work-life balance and nursing performance as well as external compensation.

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Hodgetts, Michael. « A Topographical Index of Hiding-Places, III ». Recusant History 27, n^o 4 (octobre 2005) : 473–520. http://dx.doi.org/10.1017/s0034193200031630.

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This is the third and (barring further significant discoveries) the final part of my index, the first and second parts of which were published in Recusant History in October 1982 (nos. 1–177) and May 1998 (nos. 178–300). In Part II, for reasons of space and cost, I omitted, unless there was more to report on them, houses mentioned in my Secret Hiding-Places (1989) but not included in Part I. For reference and analysis, however, it is inconvenient to have a numbered list and a book, each including houses not in the other; and in any case there is now more to report on many of these houses. The one hundred houses in Part III (nos. 301–400) therefore include all sixty-nine of those that were mentioned, however briefly, in Hodgetts 1989 and were not included in Parts I or II. Among them is Scotney Old Castle in Kent (no. 320), which is one of only ten houses in the country where there is a surviving hide mentioned in an Elizabethan or Stuart account of a search. Forty-eight of the hundred were in Granville Squiers’ Secret Hiding-Places (1933).

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Hamimu, La Hamimu, Agnes Maindan et Abdul Manan. « Determinatioan Of Sediment Thickness By Using Microtremor Data In Kadia Sub-District, Kendari City ». Jurnal Rekayasa Geofisika Indonesia 5, n^o 02 (14 novembre 2023) : 98–106. http://dx.doi.org/10.56099/jrgi.v5i02.21.

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This study aims to determine the value of the distribution of sediment layer thickness. This research was conducted in the Kadia District area, Kendari City, with data collection carried out at 16 measurement points with intervals for each point varying from 400 to 600 meters with a sampling frequency of 100 Hz. The data obtained from this study is in the form of ground vibration data which is then downloaded software DataPro.exe East-Westhorizontal component, the North-South vertical component Up-Down. The downloaded microtremor data is then processed using a device software Geopsy 4.3.2 to obtain the H/V curve. The dominant frequency value (f0) is obtained from the H/V curve with a dominant frequency range of 1.247 Hz to 4.955 Hz and the shear (VS30) is obtained from the website www.USGS.gov with a VS30 of 276 m/s up to 301 m/s. Based on the data that has been obtained, the distribution value of the sediment layer thickness (h) will be determined. The value of the thickness of the sediment layer (h) in the study area ranged from 13,016 meters to 59,473 meters.

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Olsson, Annika, Mattias Pirholt, Anna Bohlin, Örjan Torell, Roland Lysell, Sofi Qvarnström, Alexandra Borg et Jørgen Bruhn. « Recensioner ». Tidskrift för litteraturvetenskap 39, n^o 3-4 (1 janvier 2009) : 113–33. http://dx.doi.org/10.54797/tfl.v39i3-4.12049.

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Annika Olsson om Margareta Petersson, Globaliseringens ansikten: den indoengelska romanenStockholm: Carlssons, 2008, 400 s. Mattias Pirholt om Leena Eilittä, Ingeborg Bachmann’s Utopia and Disillusionment: IntroductionHelsingfors: Finnish Academy of Science and Letters, 2008, 164 s. Anna Bohlin om Boel Englund & Lena Kåreland, Rätten till ordet: En kollektivbiografi över skrivandeStockholmskvinnor 1880–1920 Stockholm: Carlsson, 2008, 409 s. Örjan Torell om Christer Ekholm och Staffan Thorsson (red.), Främlingskap och främmandegöring: Förhållningssätt till skönlitteratur i universitetsundervisningenGöteborg: Daidalos, 2009, 554 s. Roland Lysell om Johan Sahlin, Om kyrklundheten: Värde, kunskap och skrivande i Willy Kyrklunds Om godhetenLund: ellerströms, 2008, 252 s. (diss. Växjö) Sofi Qvarnström om Peter Forsgren, I vansklighetens land: Genus, genre och modernitet i Elin Wägners smålandsromanerGöteborg: Makadam förlag, 2009, 263 s. Alexandra Borg om Örjan Torell, Den osynliga staden: en gestaltningsmodell hos Olof Högberg, Ludvig Nordström, Bertil Malmberg, Birger Sjödin, Karl Östman, Lars Ahlin och andra svenska författare fram till våra dagarUmeå: Bokförlaget H:ström – Text & Kultur, 2009, 301 s. Jørgen Bruhn om Christer Johansson, Mimetiskt syskonskap: en representationsteoretisk undersökning av relationen fiktionsprosa- fiktionsfilm Stockholm: Acta universitatis stockholmiensis, 2008, 446 s. (diss. Stockholm)

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Aijaz, Saba, Ambreen Shahzad, Muhammad Faisal Fahim, Aisha Ahmed, Urooj Asghar et Muntaha Mukhtar. « Frequency of Neck Pain Among Female Medical Students in a Medical University of Karachi ». New Emirates Medical Journal 1, n^o 1 (21 février 2020) : 11–16. http://dx.doi.org/10.2174/0250688202002021102.

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Background: Among all the Musculoskeletal Pain (MSP), the most commonly reported MSP among the undergraduate medical students is the neck pain. As the students study for long hours sitting in front of the computers, use incorrect postures while using the computers, mobile phones, reading, etc. The females face neck problems due to increase stress in their daily life. Our study aims to find out how prevalent is the neck pain among female medical students in a Medical University of Karachi. Methodology: The study conducted was a cross-sectional survey with a study duration of 4 months i.e. from January, 2018 till April, 2018. A non-probability purposive sampling, conducted among the female undergraduate students of Doctor of Physiotherapy (DPT), Bachelor of Dental Surgery (BDS), Bachelor of Medicine and Bachelor of Surgery (MBBS) and Doctor of Pharmacy (Pharm-D) studying in DOW University of Health Science, Ojha campus Karachi. The estimated sample size was 400 including female undergraduate medical students of MBBS, BDS, Pharm-D and DPT of DOW University, Ojha campus. Male medical students and students other than DOW University, Ojha campus were not included in this study. Data was analyzed through SPSS version 16.0. Pearson Chi-Square test was used to see the association between neck pain and different physical parameters of the Neck Disability Index. P-value less than 0.05 was considered significant. Results: The results showed that out of 400 female medical students 301 students were having neck pain among which 24.8% of students reported no disability, 36.5% reported mild disability, 9.5% reported severe disability, and 4.5% reported complete disability. Conclusion: It was concluded that the majority of the female medical students were having neck pain with mild disability due to the presence of neck pain.

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Nair, Indu V., et Supahala Kotian. « Body Image Perception among Adolescent Girls – Association with Socio-demographic Factors : A Descriptive Study in Urban Mangalore ». RESEARCH REVIEW International Journal of Multidisciplinary 8, n^o 6 (15 juin 2023) : 67–74. http://dx.doi.org/10.31305/rrijm.2023.v08.n06.010.

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Background: Body image encompasses an individual’s thoughts, beliefs, emotional evaluations and behaviors regarding their physical appearance. Adolescents, due to the physical, social and psychological transformations they experience are especially susceptible to experiencing body dissatisfaction. In the case of adolescent girls, various bodily and social changes occur during and after puberty, significantly impacting their body image, with these effects becoming more prominent as they reach late adolescence. Methodology: The current study aims to embrace a post positivist worldview, which aligns with the conventional research approach and is primarily associated with quantitative research rather than qualitative research. The Universe of the study was all the 222 colleges which are affiliated to Mangalore University and the population was only those colleges located in the geographical area of Mangalore city. The first phase of the sampling procedure was selection of 10 colleges in the urban Mangalore by applying the random sampling method and in second phase included the selection of girl students from the college. A sample size of 400 adolescent girls have selected by using Krejcie and Morgan table. Results: It was very clear from the findings that out of 400 respondents 301 girls have agreed that social media has influence on their diet pattern. The study results showed a significant association between the domicile, family status and the career choice of the respondents with their body image issues. Conclusion: This study highlights the growing prevalence of body image dissatisfaction among adolescent girls in the Urban Mangalore, emphasizing that is not limited to western societies. It underscores the need for proactive measures to address this issue and promote awareness about the concept of ideal body weight, thereby safeguarding the well-being of the younger generation against the detrimental effects of negative body image.

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Janovszky, Dora. « Strengthening of Nanocrystalline Al with Al3Zr Core-Shell Structure ». Metals 10, n^o 9 (24 août 2020) : 1144. http://dx.doi.org/10.3390/met10091144.

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High-density Al-based composites reinforced with ten-wt.% recycled nanocrystalline CuZrAgAl particles have been fabricated by mechanical milling, cold- and hot-pressing. The microstructures, phase transformations, and mechanical properties of the mixed powder and sintered samples were investigated. After milling in a ball mill for 30 h, the microhardness of the mixed powder increases to 301 ± 31 HV0.01 and 222 ± 10 HV0.01 without and with ethanol milling, respectively. On account of the interdiffusion, the melting temperature of mixed powder reduces to 574 ± 5.0 °C and 627.5 ± 6.5 °C after 30 h milling. The study showed that the reinforcing particles are homogeneously distributed in the sintered nanocrystalline Al-based composites. During the hot-pressing, a shell zone forms at the interface of reinforcing particles during hot pressing after high energy milling with a minimum of ten hours milling time. This shell zone consists of Al3Zr (D023) phase. The coarsening resistant core-shell structure and grain refinement greatly improve mechanical properties. The compression strength at room temperature varies between 650 and 800 MPa at room temperature and is 380 MPa at 400 °C for the composite containing ten-wt.% of the Cu-Zr-based amorphous-nanocrystalline phases. The Brinell hardness of the sintered composite is 329 HB.

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Vijayakumar, S., Duminda S. Ranasinghe et David M. Wilmouth. « Kinetics of the Reactions of Ozone with Halogen Atoms in the Stratosphere ». Atmosphere 12, n^o 8 (17 août 2021) : 1053. http://dx.doi.org/10.3390/atmos12081053.

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It is well established that reaction cycles involving inorganic halogens contribute to the depletion of ozone in the atmosphere. Here, the kinetics of O3 with halogen atoms (Cl, Br, and I) were investigated between 180 and 400 K, expanding the temperature range relative to prior studies. Canonical variational transition state theory including small curvature tunneling correction (CVT/SCT) were considered, following the construction of the potential energy surfaces. MRCI + Q/aug-ano-pVTZ//MP2/aug-cc-pV(T + d)Z and MRCI + Q/aug-ano-RCC-VTZP//MP2/aug-cc-pV(T + d)Z levels of theory were used to calculate the kinetic parameters. Calculated rate coefficients were used to fit the Arrhenius equations, which are obtained to be k1 = (3.48 ± 0.4) × 10−11 exp[(−301 ± 64)/T] cm3 molecule−1 s−1, k2 = (3.54 ± 0.2) × 10−11 exp[(−990 ± 35)/T] cm3 molecule−1 s−1 and k3 = (1.47 ± 0.1) × 10−11 exp[(−720 ± 42)/T] cm3 molecule−1 s−1 for the reactions of O3 with Cl, Br, and I atoms, respectively. The obtained rate coefficients for the reactions of O3 with halogen atoms using CVT/SCT are compared to the latest recommended rate coefficients by the NASA/JPL and IUPAC evaluations. The reactivity trends and pathways of these reactions are discussed.

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Rønsbo, Jørn G., Tonči Balić-Žunić et Ole V. Petersen. « Dyrnaesite-(La) a new hyperagpaitic mineral from the Ilímaussaq alkaline complex, South Greenland ». Mineralogical Magazine 81, n^o 1 (février 2017) : 103–11. http://dx.doi.org/10.1180/minmag.2016.080.075.

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AbstractThe new mineral, dyrnaesite-(La), is found in the Ilímaussaq alkaline complex, South Greenland. The holotype material originates from an arfvedsonite lujavrite sheet as an accessory mineral. Dyrnaesite-(La) is pale yellowish green, with no cleavage and an irregular fracture. Density is 3.68(2)/3.682 g/cm3(measured/ calculated). It is biaxial, negative, 2Vα = 47(1)/48 (measured/calculated); α = 1.6226(5), β = 1.6852(10), γ = 1.6982(2);X=c,Y=a,Z=b. The average values of microprobe analyses are (wt.%) P2O537.17, SiO20.15, CaO 0.90, Na2O 20.06, La2O316.44, CeO220.23, Pr2O31.40, Nd2O33.47, Sm2O30.24, Dy2O30.06, Y2O30.06.The crystal structure was solved from single-crystal X-ray diffraction data. Dyrnaesite-(La) is orthorhombic,Pnma;a= 18.4662(7) Å,b= 16.0106(5) Å,c= 7.0274(2) Å,V= 2077.7(2) Å3,Z= 4. The structural formula calculated from the diffraction data and microprobe analysis is Na7.89(Ce0.94Ca0.06)∑1.00(Ca0.12La1.14Ce0.40Pr0.10Nd0.24)∑2.00(PO4)6, the simplified formula is Na8Ce4+REE2(PO4)6. The crystal structure is related closely to that of vitusite-(Ce), but is distinct from it in several aspects. The five strongest lines of the powder X-ray diffraction pattern are (d Å, (I %), (hkl)); 6.57 (100) (101), 4.62 (40) (301, 230, 400), 3.50 (40) (331), 2.80 (86) (232, 402), 2.67 (54) (060,630).

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Kerch, H. M., R. A. Gerhardt et J. L. Grazul. « A Transmission Electron Microscopic study of the densification of 10:90 colloidal silica : Alkali silicate sol-gels ». Proceedings, annual meeting, Electron Microscopy Society of America 47 (6 août 1989) : 436–37. http://dx.doi.org/10.1017/s0424820100154159.

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The sintering behavior of a low density 10:90 wt% colloidal silica: potassium silicate sol-gel is being investigated. This material is of technological interest because of its ease of processing, high purity and relatively low sintering temperature. Porous structures are most frequently characterized by mercury penetration porosimetry and B.E.T. sorption technique. The underlying theory of both these procedures assume a priori knowledge of the pore geometry. Conversely, microscopic analysis allows direct observation of the pore network provided sample preparation does not alter the structure. To this end, the techniques of ultramicrotomy and Pt/C replication were adopted.Specimen preparation for ultramicrotomy is described elsewhere. All thin-sectioning was performed with a D.D.K. diamond knife using a distilled water media. The replicas were produced by a Balzers 301 freeze etch apparatus at a vacuum of 1 X 10-7 Torr. Platinum was evaporated at a thickness of 2.5 nm at 45° followed by a 15 nm layer of carbon deposited at 90°. The replicas were retrieved by immersing the gel in HF with a distilled water rinse. Both ultramicrotomed sections and replicas were collected onto carbon coated 400 mesh grids. All micrographs were taken on a JEOL 100CX in bright field mode.

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Filippi, Alessandro, Marianna Alacqua, Warren Cowell, Annabelle Shakespeare, Lorenzo Mantovani, Cosetta Bianchi, Claudio Cricelli et Giampiero Mazzaglia. « A national survey of the management of atrial fibrillation with antithrombotic drugs in Italian primary care ». Thrombosis and Haemostasis 103, n^o 05 (2010) : 968–75. http://dx.doi.org/10.1160/th09-08-0525.

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SummaryThe aims of this study were to investigate trends in the incidence of diagnosed atrial fibrillation (AF), and to identify factors associated with the prescription of antithrombotics (ATs) and to identify the persistence of patients with oral anticoagulant (OAC) treatment in primary care. Data were obtained from 400 Italian primary care physicians providing information to the Health Search/Thales Database from 2001 to 2004. The age-standardised incidence of AF was: 3.9–3.0 cases, and 3.6–3.0 cases per 1,000 person-years in males and females, respectively. During the study period, 2,016 (37.2%) patients had no prescription, 1,663 (30.7%) were prescribed an antiplatelet (AP) agent, 1,440 (26.6%) were prescribed an OAC and 301 (5.5%) had both prescriptions. The date of diagnosis (p = 0.0001) affected the likelihood of receiving an OAC. AP, but not OAC, use significantly increased with a worsening stroke risk profile using the CHADS2 risk score. Older age increased the probability (p < 0.0001) of receiving an AP, but not an OAC. Approximately 42% and 24% of patients persisted with OAC treatment at one and two years, respectively, the remainder interrupted or discontinued their treatment. Underuse and discontinuation of OAC treatment is common in incident AF patients. Risk stratification only partially influences AT management.

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ÖZER, Beril. « Türkiye’de 2000-2020 Yılları Arasında Yazılan ve Eğitim Örgütlerindeki Sinizmi İnceleyen Lisansüstü Tezlerin İçerik Analizi ». Dokuz Eylül Üniversitesi Buca Eğitim Fakültesi Dergisi, n^o 54 (28 décembre 2022) : 831–53. http://dx.doi.org/10.53444/deubefd.1064459.

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Bu çalışmanın amacı, 2000-2020 yıllarını kapsayan yirmi yıllık süreçte, eğitim örgütlerine yönelik yapılan ve örgütsel sinizm olgusunu inceleyen çalışmaları betimsel olarak incelemek, kavramın hangi konular ile ilişkilendirildiğini ve hangi değişkenlere göre ayrıştığını tespit etmektir. Önceden belirlenen kriterler doğrultusunda seçilen ve yalnızca Yök Tez-Ulusal Tez Merkezi’nde izinli durumda bulunan yüksek lisans ve doktora tezlerinin araştırma örneklemine dahil edildiği çalışmada 139 yüksek lisans ve doktora tezine ulaşılmıştır. Belirli kategorilere ayrıştırılan tezler IBM SPSS 22 programıyla “Frekans analizi, Çapraz analiz ve Chi-Square (Ki- Kare) testine tabi tutulmuştur. Veri analizi sonucunda; 139 tezin 99’unun (%71,2) 2017-2020 yılları arasında yazıldığı, 120 tez (%86,3) yüksek lisans tezi iken 19’unun (%13,7) doktora tezi olduğu, 108 tezin (%77,7) okul öncesi ve 1-2-3. eğitim kademesi ile karma eğitim kademesine yönelik gerçekleştirildiği, 98 tezin (%70,5) araştırmacısının bağlı olduğu anabilim dalının eğitim bilimleri anabilim dalı olduğu, en fazla tercih edilen örneklem sayısının 45 sıklık ile (%32,4) 301-400 olduğu, en fazla çalışmanın 37 sıklık ile (%26,6) Marmara Bölgesi’nde gerçekleştirildiği, 102 tezin (%73,4) öğretmenlere yönelik örgütsel sinizmi araştırdığı, en çok tercih edilen veri toplama yönteminin 137 sıklıkla (%98,6) ölçek (anket) yöntemi olduğu ve en çok tercih edilen ölçeğin 94 (%67,6) sıklık ile Brandes ve diğerlerinin 1999’da geliştirdiği örgütsel sinizm ölçeği olduğu tespit edilmiştir.

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Kudo, Masatoshi, Richard S. Finn, Tim Meyer, Frederic Boisserie, Songzi Li, Yaxi Chen, Ramil Abdrashitov, Andrew X. Zhu, Arndt Vogel et Shukui Qin. « Impact of risk factors on overall survival (OS) in patients (pts) with unresectable hepatocellular carcinoma (HCC) treated with first-line (1L) tislelizumab (TIS). » Journal of Clinical Oncology 41, n^o 16_suppl (1 juin 2023) : 4083. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.4083.

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4083 Background: TIS is a monoclonal antibody with high affinity and specificity for programmed cell death protein 1. In the phase 3 RATIONALE-301 trial (NCT03412773), TIS demonstrated non-inferior OS versus sorafenib (SOR) as 1L monotherapy for unresectable HCC (median [m] OS 15.9 [TIS] vs 14.1 [SOR] months [mo]; hazard ratio [HR] 0.85), with a favorable safety profile. Certain biomarkers are potential prognostic factors and may impact OS in 1L treatment of unresectable HCC; this exploratory analysis examined the effect of albumin-bilirubin (ALBI) grade, platelet count, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) as predictors of OS in RATIONALE-301. Methods: Systemic therapy-naïve adults with histologically confirmed HCC (Barcelona Clinic Liver Cancer Stage C or Stage B that was not amenable to or progressed after loco-regional therapy; Child-Pugh A), with ≥1 measurable lesion per RECIST v1.1, and an ECOG performance status ≤1 were randomized 1:1 to receive TIS (200 mg IV Q3W) or SOR (400 mg orally BID) until disease progression, intolerable toxicity, or withdrawal. The primary endpoint was OS. Results: Overall, 674 pts were randomized (TIS n=342; SOR n=332). At data cutoff (July 11, 2022), minimum study follow-up was 33 mo. Demographic and baseline characteristics for biomarkers were generally balanced across arms. Numerically longer (≥2 mo) mOS was observed in biomarker subgroups ALBI grade 1 vs 2 and NLR ≤3 vs >3 with TIS or SOR, and PLR ≤141 vs >141 with TIS. Both platelet count threshold subgroups were accompanied by a smaller difference (<2 mo) in mOS between biomarker cutoffs, which may indicate limited prognostic value for this biomarker. TIS also demonstrated numerically longer OS versus SOR in the same subgroup categories: ALBI grade 1, PLR ≤141, and NLR ≤3. Conclusions: This analysis suggests that ALBI grade, PLR, and NLR could have prognostic value for OS, irrespective of treatment. TIS demonstrated numerically improved mOS compared with SOR for PLR ≤141 and NLR ≤3, suggesting higher benefit for pts with a more favorable balance between systemic inflammation and immunity. Clinical trial information: NCT03412773 . [Table: see text]

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Goetsch, A. L., et C. L. Ferrell. « Effects of dietary maize level on net flux across splanchnic tissues of oxygen and nutrients in wethers consuming ad libitum different forages ». Animal Science 61, n^o 1 (août 1995) : 43–55. http://dx.doi.org/10.1017/s1357729800013503.

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AbstractCrossbred wethers (34 (s.e. 0·9) kg), with catheters in a hepatic vein, the portal vein and a mesenteric vein and artery, were offered ad libitum alfalfa (A), bermudagrass (B) or ryegrass-wheat (RW) hay and approximately 0, 200 or 400 g/kg maize (dry matter) to determine influences of maize level on net flux of oxygen and nutrients across the portal-drained viscera (PDV) and liver with different forage sources. Digestible energy intake (MJ/day) was 8·5, 12·0 and 12·8 (s.e. VIS) for A; 4·5, 5·5 and 9·0 (s.e. 0·93) for B; and 9·4, 8·8 and 12·2 (s.e. 0·93) for RW with 0, 200 and 400 g/kg maize, respectively. Splanchnic bed oxygen consumption (mmol/h) was 301, 304 and 322 (s.e. 27·2) for A; 178, 187 and 217 (s.e. 30·0) for B; and 226, 133 and 233 (s.e. 19·0) for RW with 0, 200 and 400 g/kg maize, respectively. Increasing dietary maize level linearly increased (P < 0·05) PDV release of alpha-amino nitrogen with B (5, 9 and 14 mmol/h) but not with A or RW. Dietary maize level did not consistently alter PDV or hepatic net flux of urea or ammonia nitrogen, suggesting that changes in ruminally fermentable organic matter from diets offered ad libitum, presumably induced by varying dietary concentrate level, may not alter nitrogen recycling when forage is 86 g/kg or greater in crude protein. Propionate release by the PDV and hepatic uptake increased linearly (P < 0·08) as maize level in A and B diets increased, although increasing dietary maize level did not significantly alter PDV, hepatic or splanchnic bed net flux of glucose regardless of forage source. Nevertheless, glucose concentration in arterial blood with A and RW increased linearly fP < 0·05) with increasing maize level, suggesting increased peripheral glucose availability. In conclusion, the potential to decrease energy consumption by splanchnic tissues relative to digestible energy intake by dietary inclusion of maize, thereby increasing the proportion of absorbed energy available to extra-splanchnic tissues, may be greater for low-quality forage than for forage of moderate or high quality and for moderate v. low dietary levels of maize with low-quality forage.

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Aldè, Mirko, Henri Albert Didier, Aldo Bruno Giannì, Fabiola Sessa, Giulia Borromeo, Alexandre Henri Didier, Stefania Barozzi, Diego Zanetti et Federica Di Berardino. « Prevalence of New-Onset Otological Symptoms in Patients with Temporomandibular Disorders ». Journal of Otorhinolaryngology, Hearing and Balance Medicine 3, n^o 2 (19 avril 2022) : 3. http://dx.doi.org/10.3390/ohbm3020003.

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The aim of this retrospective study was to evaluate the prevalence of new-onset otological symptoms and the possible associations between tinnitus and oral parafunctional habits among patients with temporomandibular disorders (TMD) who attended a Craniofacial Pain Outpatient and a Dentistry Clinic. The medical reports and charts of patients who experienced TMD between 1 February 2016 and 31 December 2017 were reviewed, in order to evaluate the prevalence of new-onset aural fullness, vertigo and tinnitus. Tinnitus was also analyzed in more detail to evaluate possible associations with parafunctional habits. A total of 400 patients (301 females, 99 males) met the inclusion criteria, with a median age of 39.6 ± 15.6 years. Overall, new-onset otological symptoms were reported by 304 (76%) subjects with TMD. Among otological symptoms, aural fullness was the most common (n = 133, 33.3%), followed by tinnitus (n = 92, 23%) and vertigo (n = 79, 19.8%). No significant correlations were found between tinnitus and bruxism (p = 0.28), clenching (p = 0.11), nail-biting (p = 0.96), sleeping prone (p = 0.27), chewing gum (p = 0.99) and talking for a long time (p = 0.42). The present study suggests that all patients with TMD should be investigated for new-onset otological symptoms, regardless of oral parafunctional habits. Early diagnosis would allow to plan personalized and appropriate therapeutic and rehabilitative pathways, minimizing the negative impact due to TMD.

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Franco, M. Jimena, Eliana Moya, Mariana Brea et Camila Martínez Martínez. « Astroniumxylon, Schinopsixylon, and Parametopioxylon n. gen. fossil woods from upper Cenozoic of Argentina : taxonomic revision, new taxon and new records ». Journal of Paleontology 94, n^o 2 (17 décembre 2019) : 185–201. http://dx.doi.org/10.1017/jpa.2019.97.

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AbstractThis paper presents new descriptions of Anacardiaceae fossil woods from the Ituzaingó Formation (late Cenozoic) at the Toma Vieja, Curtiembre, and Arroyo El Espinillo localities, Argentina. We describe eight silicified woods assigned to four different species in three genera, one of which, Parametopioxylon crystalliferum n. gen. n. sp., is new. Similarities between these three genera and the six Anacardiaceae species previously recorded from the late Cenozoic in northeastern Argentina are investigated using multivariate analysis techniques (correspondence and cluster analysis). Our study is based on 33 characters scored for 17 fossil specimens (10 Astroniumxylon Brea, Aceñolaza, and Zucol 2001; five Schinopsixylon Lutz, 1979; and two Parametopioxylon n. gen.) and four extant species (Astronium balansae Engl., Astronium urundeuva Engl., Schinopsis balansae Engl., and Metopium sp.). Our main goal is to determine the wood anatomical features useful for distinguishing among these species. Results of the multivariate analyses support the previous classification where Schinopsixylon is distinguished from Astroniumxylon by having exclusively paratracheal axial parenchyma, ≥30% multiseriate rays, and multiseriate rays that are ≥5 cells wide and commonly 301–400 μm in height. Additionally, we propose that Schinopsixylon heckii Lutz, 1979 is synonymous with S. herbstii Lutz, 1979. A diagnostic key for the fossil species studied is given. Wood anatomy of Anacardiaceae fossil woods from Argentina (late Cenozoic) suggests a warm, dry to semi-humid climate for this region, supporting previous studies.

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Zahm, Jean-Marie, Sonia Baconnais, Donald J. Davidson, Sheila Webb, Julia Dorin, Noel Bonnet, Gérard Balossier et Edith Puchelle. « X-ray microanalysis of airway surface liquid collected in cystic fibrosis mice ». American Journal of Physiology-Lung Cellular and Molecular Physiology 281, n^o 2 (1 août 2001) : L309—L313. http://dx.doi.org/10.1152/ajplung.2001.281.2.l309.

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The airway surface liquid (ASL) that lines the airway surface epithelium plays a major role in airway antibacterial defense and mucociliary transport efficiency, two key factors in cystic fibrosis (CF) disease. A major difficulty is to collect ASL in native conditions without stimulation or alteration of the underlying airway epithelium. Using a cryoprobe specifically adapted to collect native ASL from the tracheal mouse surface, we analyzed by X-ray microanalysis the complete ASL and plasma ion content in Cftrtm1Hgu/Cftrtm1Hgu mice compared with that in control littermates. ASL ion content from eight Cftrtm1Hgu/Cftrtm1Hgu mice and eight control littermates did not appear significantly different. The mean (±SE) concentrations were 2,352 ± 367 and 2,058 ± 401 mmol/kg dry weight for Na, 1,659 ± 272 and 1,448 ± 281 mmol/kg dry weight for Cl, 357 ± 57 and 337 ± 38 mmol/kg dry weight for S, 1,066 ± 220 and 787 ± 182 mmol/kg dry weight for K, 400 ± 82 and 301 ± 58 mmol/kg dry weight for Ca, 105 ± 31 and 105 ± 20 mmol/kg dry weight for Mg, 33 ± 15 and 29 ± 9 mmol/kg dry weight for P in non-CF and CF mice, respectively. This cryotechnique appears to be a promising technique for analyzing the complete elemental composition of native ASL in CF and non-CF tissues.

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Porto, Luiz Guilherme Grossi, Edgard M. K. V. K. Soares, Sushant M. Ranadive, Adriana Lofrano-Porto et Denise L. Smith. « Association of Endogenous Testosterone with Physical Fitness Measures during Firefighter Occupational Health Evaluations ». International Journal of Environmental Research and Public Health 21, n^o 3 (27 février 2024) : 274. http://dx.doi.org/10.3390/ijerph21030274.

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Firefighting is a physically demanding profession associated with unacceptably high on-duty cardiovascular mortality. Low endogenous total testosterone (TT) is an emerging cardiometabolic (CM) risk factor in men, but limited data exists on its interactions with physical fitness (PF). Data from occupational health and fitness assessments of 301 male career firefighters (FFs) were analyzed. TT was categorized as low (<264 ng/dL), borderline (264–399 ng/dL), and reference (400–916 ng/dL). PF tests included cardiorespiratory fitness (submaximal treadmill), body fat percentage (BF%), push-ups, plank, and handgrip strength assessments. In the crude analyses, FFs in the low TT group had worse muscular and cardiorespiratory fitness measures compared to the referent group. However, after adjusting for age and BF%, none of the PF differences remained statistically significant. Similarly, the odds of less-fit FFs (PF performance below median values) having low TT were higher compared to the fitter ones only before adjusting for age and BF%. Therefore, in the final adjusted model, there was no significant association between TT and PF. Our data suggest that age and body fat confound the association between PF and TT. Low TT and poor PF are important components of FFs’ CM risk profile, and there is potential benefit to considering TT screening as part of a comprehensive occupational health program that manages performing medical evaluations and provides education and preventative programming.

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Samudyatha, U. C., Kathirvel Soundappan, Gomathi Ramaswamy, Kedar Mehta, Chandan Kumar, M. Jagadeesh, B. T. Prasanna Kamath, Neeta Singla et Pruthu Thekkur. « Outcomes and Challenges in the Programmatic Implementation of Tuberculosis Preventive Therapy among Household Contacts of Pulmonary TB Patients : A Mixed-Methods Study from a Rural District of Karnataka, India ». Tropical Medicine and Infectious Disease 8, n^o 12 (30 novembre 2023) : 512. http://dx.doi.org/10.3390/tropicalmed8120512.

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The National TB Elimination Programme (NTEP) of India is implementing tuberculosis preventive treatment (TPT) for all household contacts (HHCs) of pulmonary tuberculosis patients (index patients) aged <5 years and those HHCs aged >5 years with TB infection (TBI). We conducted an explanatory mixed-methods study among index patients registered in the Kolar district, Karnataka during April-December 2022, to assess the TPT cascade and explore the early implementation challenges for TPT provision. Of the 301 index patients, contact tracing home visits were made in 247 (82.1%) instances; a major challenge was index patients’ resistance to home visits fearing stigma, especially among those receiving care from the private sector. Of the 838 HHCs, 765 (91.3%) were screened for TB; the challenges included a lack of clarity on HHC definition and the non-availability of HHCs during house visits. Only 400 (57.8%) of the 692 eligible HHCs underwent an IGRA test for TBI; the challenges included a shortage of IGRA testing logistics and the perceived low risk among HHCs. As HHCs were unaware of their IGRA results, a number of HHCs actually eligible for TPT could not be determined. Among the 83 HHCs advised of the TPT, 81 (98%) initiated treatment, of whom 63 (77%) completed treatment. Though TPT initiation and completion rates are appreciable, the NTEP needs to urgently address the challenges in contact identification and IGRA testing.

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Bahiyah Baba, N., A. S. Ghazali, S. N. Azinee, A. H. Abdul Rahman et S. Sharif. « Effect of particle size on surface roughness and morphology of heat-treated electroless Ni-YSZ coating ». Journal of Achievements in Materials and Manufacturing Engineering 114, n^o 1 (1 septembre 2022) : 5–14. http://dx.doi.org/10.5604/01.3001.0016.1477.

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The paper discusses the surface characterisation of electroless nickel-yttria-stabilised zirconia (Ni-YSZ) coating with varying YSZ particle sizes and undergoes heat treatment at a temperature between 300-400°C for 1-2 hours for wear resistance purposes. This finding will be helpful to the application of Ni-YSZ as an alternative coating for cutting tools. The surface characterisation was analysed using JOEL Scanning Electron Microscope (SEM) coupled with Energy Dispersive X-ray (EDX) JSM 7800F. The crystallographic structure of materials was analysed by X-ray diffraction (XRD) Bruker D8 Advance instrument. The Ni-YSZ coating was deposited using electroless nickel co-deposition of 8YSZ ceramic particles with a nano, mixed and microparticle sizes onto a high-speed steel (HSS) substrate. The coatings were heat treated at temperature 300-400°C and time 1-2 hours. The surface roughness was measured using Mitutoyo surface roughness tester SJ-301. The electroless Ni-YSZ coating deposited has an average thickness of 30 µm. It is found that the coating morphology electroless coating without YSZ particle incorporation (EN) and Ni-YSZ nano (N) is smoother compared to the Ni-YSZ mixed (NM) and Ni-YSZ micro (M). The EDS composition analysis shows the YSZ content in the electroless Ni-YSZ coating for N samples is the lowest, whereas NM samples are the highest. This resulted in the surface roughness behaviour where the mixed-size YSZ particle gives the highest roughness at all temperatures. The XRD analysis shows that heating temperatures above 300°C caused the precipitation of Ni3P crystalline. Previous studies in the surface characterisation of electroless nickel composite are scarce; thus, the study has limitations in finding supporting data. The surface characterisation especially related to the surface roughness of the electroless nickel, either the Ni-P or composites or alloys are rarely reported. Thus, this study enlightened the effect of particle size on surface roughness and morphology of heat-treated coatings.

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Kakumba, Jocelyn Mankulu, Jérémie Mbinze Kindenge, Paulin Mutwale Kapepula, Jean-Marie Liesse Iyamba, Murielle Longokolo Mashi, Jose Wambale Mulwahali et Didi Mana Kialengila. « Evaluation of Antibiotic Prescribing Pattern Using WHO Access, Watch and Reserve Classification in Kinshasa, Democratic Republic of Congo ». Antibiotics 12, n^o 8 (27 juillet 2023) : 1239. http://dx.doi.org/10.3390/antibiotics12081239.

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Background: The AWaRe tool was set up by the World Health Organization (WHO) to promote the rational use of antimicrobials. Indeed, this tool classifies antibiotics into four groups: access, watch, reserve and not-recommended antibiotics. In The Democratic Republic of Congo, data on antibiotic dispensing (prescribing) by health professionals according to the AWaRe classification are scarce. In this research work, we aimed to explore antibiotic dispensing pattern from health professionals according to the WHO AWaRe classification to strengthen the national antimicrobial resistance plan. Methods: For this purpose, a survey was conducted from July to December 2022 in the district of Tshangu in Kinshasa. From randomly selected drugstores, drug-sellers were interviewed and randomly selected customers attending those drugstores were included in the study for medical prescriptions collection. The prescribed antibiotics were classified into the access, watch, reserve and not-recommended antibiotics group and by antibiotics number by prescription among pharmacies surveyed. Results: 400 medical prescriptions were collected from 80 drugstores and among which, 301 (75.25%) contained antibiotics. Out of 301 prescriptions, we noticed 164 (54.5%) containing one antibiotic, 117 (38.9%) containing two antibiotics, 15 (5%) containing three antibiotics and 5 (1.6%) containing four antibiotics. A total of 463 antibiotics were prescribed and distributed as 169 (36.5%) were from the access group, 200 (43.2%) from the watch group and 94 (20.3%) from not-recommended antibiotics group, respectively. This can explain the fact of emerging bacterial strains, as, according to the WHO recommendations, the access group should be prioritized because of its activity against a wide range of commonly encountered pathogens and its showing low resistance susceptibility compared to antibiotics from other groups. Based on the anatomical, therapeutic and chemical (ATC) classifications, we observed that third generation cephalosporins represented 34.33% of the prescribed antibiotics, followed by penicillins (17.17%), macrolides (7.63%), aminoglycosides (7.36%) and Imidazole (7.36%), thus accounting approximately for 74% of the classes of antibiotics prescribed. Additionally, among them, the most frequently prescribed antibiotics were Ceftriaxone (21.38%), Amoxicillin (11.01%), Gentamycin (5.61%), Amoxicillin-clavulanic acid (5.61%), Azithromycin (4.97%) and Metronidazole (4.75%), thus accounting for approximately 54% of all the prescribed antibiotics. Conclusion: These results highlight the importance of strict implementation of the national plan to combat antimicrobial resistance and the need to train health workers in the correct application of the WHO AWaRe classification.

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Jerez-Roig, Javier, Marcello Barbosa Otoni Gonçalves Guedes, João Maria Dias e. Silva et Kenio Costa de Lima. « Análise da produção científica da Revista Brasileira de Geriatria e Gerontologia : uma revisão bibliométrica ». Revista Brasileira de Geriatria e Gerontologia 17, n^o 3 (septembre 2014) : 659–71. http://dx.doi.org/10.1590/1809-9823.2014.14116.

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OBJETIVO: Descrever e analisar o perfil das publicações da Revista Brasileira de Geriatria e Gerontologia (RBGG) no período de 2006 a 2013. MÉTODO: Trata-se de pesquisa de revisão bibliográfica, do tipo descritivo, com análise bibliométrica da produção científica da RBGG. A coleta dos dados foi realizada por três pesquisadores treinados. Contatou-se a equipe editorial via correio eletrônico para obter a informação referente ao número de manuscritos recebidos, rejeitados e aceitos na revista. RESULTADOS: Publicou-se um total de 400 trabalhos, dos quais 301 (75,3%) foram artigos originais e 42 (10,5%) revisões. A maior parte dos trabalhos (95,1%) é de autores brasileiros, predominando as Regiões Sudeste (43,4%) e Sul (26,8%), especificamente nos estados de São Paulo (19,8%), Rio Grande do Sul (15,6%) e Rio de Janeiro (12,0%). A maioria dos trabalhos é de abordagem quantitativa e o tipo de estudo mais frequente é o transversal (45,9%), seguido pela revisão de literatura (13,7%) e a série de casos de tipo observacional (10,7%). Verificou-se, ainda, aumento do tempo para publicação entre 2006 e 2011, seguido por uma estabilidade até 2013. As temáticas mais comuns foram as referentes aos aspectos psicológicos do envelhecimento, atividade física e nutrição. CONCLUSÕES: Observou-se aumento continuado no número de trabalhos recebidos e publicados na RBGG durante todo o período. A produção é focada nas instituições universitárias, em âmbito nacional, e centralizada nas regiões Sudeste e Sul. Identificou-se ainda uma grande abrangência de temáticas.

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Badillo Trejo, Elizabeth, Citlalli Ángeles Sandoval, Carolina Acevedo Morales, Pamela Cano Badajóz et María Guadalupe López Sandoval. « Actitud de los trabajadores ante el uso de equipo de protección personal ». Revista CuidArte 8, n^o 15 (18 février 2019) : 56. http://dx.doi.org/10.22201/fesi.23958979e.2019.8.15.69157.

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Introducción. Según la Secretaría del Trabajo y Previsión Social e Instituto Mexicano del Seguro Social cada año se reportan 400 947 accidentes de trabajo y 8 301 enfermedades de trabajo3. Es indispensable que el grupo de salud establezca líneas de acción, que beneficien y reduzcan los costos que generan las situaciones que lesionan al trabajador. Objetivo. Conocer las actitudes del trabajador ante el uso del Equipo de Protección Personal (EPP) para establecer estrategias que disminuyan los accidentes laborales. Método. Cualitativo, de tipo fenomenológico. Con la participación de ocho trabajadores. Utilizando como técnica de recolección de datos la entrevista semi-estructurada, grabadas en audio, el análisis se llevó a cabo según Gomes9 Hallazgos. Las actitudes de los trabajadores ante el uso de EPP se expresa en cinco categorías: apatía, conformidad, exceso de confianza, indiferencia e interés. Discusión. De acuerdo con lo establecido en otras investigaciones existe similitud en los resultados, ya que como principal actitud tomada por los trabajadores es el exceso de confianza, por lo tanto el EPP comienza a ser innecesario. Conclusión. Las causas más frecuentes al desuso de los EPP son la falta de comodidad y la dificultad que les genera al realizar sus labores, se concluye que la falta de conocimiento, equipo y el exceso de confianza, representan el desuso.

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Pogliani, Enrico Maria, Fausto Rossini, Isabella Miccolis, Alessandra Ferrarlo, Daniele Perego, Ivana Casaroli, Silvia Bolis, Daniele Fagnani, Milena Brambilla et Gianmarco Corneo. « Alpha Interferon as Initial Treatment of Essential Thrombocythemia. Analysis after Two Years of Follow-Up ». Tumori Journal 81, n^o 4 (juillet 1995) : 245–48. http://dx.doi.org/10.1177/030089169508100406.

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Aims and background Recombinant alpha-interferon has been shown to be effective in essential thrombocythemia and in thrombocytosis associated with other myeloproliferative disorders. Patients and methods Twenty-five untreated patients were enrolled in our study from May 1989 to April 1992. Recombinant alpha interferon-2b was administered at an initial dose of 2 megaunits (MU)/m2 three times a week at escalating doses to 5 MU/m2 or the maximum tolerated dose. The mean follow-up for patients still in treatment at the time of this report was 35.9 months (range, 24-63). Results Fourteen patients (56%) had achieved a complete remission by a mean time of 152 days; 6 patients (24%) had achieved a good partial remission by a mean of 180 days. In addition to the favorable effect on platelet count, a marked improvement in clinical symptoms was observed. Treatment had to be discontinued in 9 patients (36%), 5 for toxicity (3 neurologic, 1 anemia and 1 severe hypertriglyceridemia) at a median of 155 days from the beginning of therapy (range, 30-400). Four patients refused to continue therapy because of low tolerance (flu-like syndrome) at mean of 160 days from the beginning of therapy (range, 34-301). Conclusions In our study, lower doses were administered compared with previous short-time trials. The present data show that interferon is an effective alternative to cytostatic agents in long-term treatment of patients with essential thrombocythemia, even when used at lower dosages.

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Falanghe Carneiro, Paulo César, Jorge Daniel Mikos, Fabiano Bendhack et Sérgio Aparecido Ignácio. « Processamento do jundiá Rhamdia quelen : rendimento de carcaça ». Revista Acadêmica : Ciência Animal 2, n^o 3 (15 juillet 2004) : 11. http://dx.doi.org/10.7213/cienciaanimal.v2i3.15082.

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O conhecimento da proporção da matéria-prima que será transformada em produtos finais para comercialização, bem como da quantidade que fará parte do resíduo do processamento permite o planejamento logístico da produção e os cálculos necessários para a avaliação da eficiência produtiva da empresa processadora de pescado. O jundiá Rhamdia quelen é um bagre nativo da América do Sul e que vem sendo estudado há alguns anos por vários grupos de pesquisa latino-americanos, apresentando resultados que atestam seu potencial para a piscicultura. O objetivo do presente trabalho foi avaliar o rendimento do jundiá como matéria-prima para o processamento mínimo em diferentes classes de pesos, a saber: 200 – 300 g, 301 – 400 g, 401 – 500 g, 501 – 600 g, 601 – 700 g, 701 – 800 g. Devido ao crescimento mais acelerado das fêmeas, apenas indivíduos do sexo feminino foram encontrados nas classes de peso acima de 500 g. O rendimento de filé foi maior para os peixes com maior peso médio (728g - 34,7%). A porcentagem de músculo abdominal esteve entre 9,3% e 11,2%. A proporção de vísceras sem as gônadas encontrou-se entre 7,8 e 9,8% e a porcentagem de gônadas das fêmeas com peso médio 572 g representou 11,1% do peso total. A descrição da composição da carcaça dos peixes cultivados tem grande importância sob o aspecto econômico e produtivo, permitindo estimativas de produtividade tanto para o piscicultor quanto para a indústria de processamento.

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