Articles de revues : « 2010 a-540 »

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Muraskas, J. K., B. J. Rau, P. R. Castillo, J. Gianopoulos et L. A. C. Boyd. « Long-term Follow-up of 2 Newborns With a Combined Birth Weight of 540 Grams ». PEDIATRICS 129, n^o 1 (12 décembre 2011) : e174-e178. http://dx.doi.org/10.1542/peds.2010-0039.

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Leonov, O., Ya Sharypina, Z. Usova, K. Suvorova et T. Sakhno. « Identification of spring wheat lines by the allelic state of Vrn genes for use in winter wheat breeding for carotenoid content ». Agrobìologìâ, n^o 1(157) (25 mai 2020) : 88–95. http://dx.doi.org/10.33245/2310-9270-2020-157-1-88-95.

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The aim of the research is allelic identifi cation of the genes Vrn A1, Vrn B1, Vrn B3, and Vrn D1 in 18 spring wheat samples and 3 lines obtained from winter-spring cross combinations with high carotenoid grain content for winter wheat breeding program. The content of carotenoid pigments in the grain ranged from 0.20 to 8.3 mg/100 g in the analyzed 143 samples of soft wheat. Samples of spring wheat were identifi ed for high content of carotenoids (more than 4.5 mg/100 g of flour): Volgouralskaya, Kinelskaya 61, Lutescens 540, Lutescens 598, Lutescens 575, Lutescens 516, Kinelskaya 2010, Omskaya 41. According to the studies, the presence of the Vrn-A1 allele established in 4 spring wheat samples (Sibiryachka 4, Frontana, Izolda, Dynastiya). The heterozygous state of the Vrn-A1 gene was determined for the Saratovskaya Zolotistaya variety. The presence of the allele Vrn-B1 was identifi ed in the samples Fora, Leningradka, Izolda, Saratovskaya Zolotistaya, Omskiy Tsirkon, Omskaya 41, Lutescens 540. For the samples Lutescens 516, L224-5 the heterozygous state of the locus Vrn-B1was determined. Analysis of the Vrn-B3 gene confi rmed the presence of the Vrn-B3 allele in all tested samples. Only variety Dynastiya carried a dominant allele. The Vrn-D1 gene was identifi ed in a recessive state in samples Fora, Sibiryachka 4, Novosibirskaya 22, Frontana, Leningradka, Kinelskaya 2010, Kinelskaya 61, Volgouralskaya, Omskaya 41, Lutescens 516, Lutescens 540, Lutescens 598, L224–5. In the variety Omskiy Tsircon gene Vrn-D1 was in a heterozygous state. The use of spring carriers of the trait – Samples Omskaya 41 and Lutescens 540, with one dominant gene Vrn-A1, and Lutescens 516, with the dominant allele of the gene Vrn-A1 and polymorphic in the Vrn B1 gene – were the most promising for the winter wheat breeding in the direction of increasing the carotenoids content in flour. Key words: bread wheat, variety, line, vernalization, carotenoids, genes Vrn A1, Vrn B1, Vrn B3, Vrn D1.

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Pradiko, I., Hariyadi, T. June et Sujadi. « Performance of three oil palm varieties on the East Coast of North Sumatra ». IOP Conference Series : Earth and Environmental Science 1133, n^o 1 (1 janvier 2023) : 012005. http://dx.doi.org/10.1088/1755-1315/1133/1/012005.

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Abstract The planting material, environmental conditions, and agricultural practices determine the oil palm performance. This research aimed to observe the performance of three oil palm varieties produced by IOPRI in Adolina Estate, Serdang Bedagai, North Sumatra. Adolina Estate is located on the eastern part and has a distinctive equatorial rainfall type with a sandy clay loam soil texture. The DyP Dumpy, DxP PPKS 540, and DxP Langkat varieties have been planted since 2010 in the same block with similar soil conditions and agricultural practices with total samples of 101, 147, and 124 trees, respectively. The growth parameters were height, length of rachis, petiole cross-section (PCS), and leaf area (LA), while the production parameters observed included the average bunch number, bunch weight, and yield. The results showed that DyP Dumpy had the slowest height growth with the most extended rachis length. DxP PPKS 540 has the highest average of PCS and LA, while the DxP Langkat had the fastest height growth and shortest rachis length. Furthermore, the DxP PPKS 540 variety produced the highest average yield, 24.85 tons ha−1, while DyP Dumpy and DxP Langkat have 23.19 tons ha−1 and 23.95 tons ha−1, respectively.

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Ahmed, Tahera. « The Bangladesh Midwifery Programme a giant step towards Safe Motherhood ». Bangladesh Journal of Bioethics 5, n^o 3 (12 janvier 2015) : 26–27. http://dx.doi.org/10.3329/bioethics.v5i3.21535.

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Safe Motherhood is not only a Reproductive Right but also a basic human right. Provision of Safe Motherhood services like skilled attendants at birth reduces maternal deaths and morbidities. Bangladesh has reduced maternal deaths from 540/ 100,000 live births in the nineties to 194 in 2010. In a recent estimate by WHO, UNICEF, UNFPA, the World Bank and the United Nations Population Division, the Maternal Mortality Rate (MMR) has declined to 170 per 100,000 live births in Bangladesh.DOI: http://dx.doi.org/10.3329/bioethics.v5i3.21535 Bangladesh Journal of Bioethics 2014; 5(3):26-27

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Trachsel, Manuel, Tobias Krieger, Paul Gilbert et Martin Grosse Holtforth. « Testing a German Adaption of the Entrapment Scale and Assessing the Relation to Depression ». Depression Research and Treatment 2010 (2010) : 1–10. http://dx.doi.org/10.1155/2010/501782.

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The construct ofentrapmentis used in evolutionary theory to explain the etiology of depression. The perception of entrapment can emerge when defeated individuals want to escape but are incapable. Studies have shown relationships of entrapment to depression, and suicidal tendencies. The aim of this study was a psychometric evaluation and validation of the Entrapment Scale in German (ES-D). 540 normal subjects completed the ES-D along with other measures of depressive symptoms, hopelessness, and distress. Good reliability and validity of the ES-D was demonstrated. Further, whereas entrapment originally has been regarded as a two-dimensional construct, our analyses supported a single-factor model. Entrapment explained variance in depressive symptoms beyond that explained by stress and hopelessness supporting the relevance of the construct for depression research. These findings are discussed with regard to their theoretical implications as well as to the future use of the entrapment scale in clinical research and practice.

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Shubina, O., I. Kulyk, P. Korsun et Ya Romanjuk. « Photometry of distant active comet C/2010 S1 (LINEAR) ». Advances in Astronomy and Space Physics 4, n^o 1-2 (2014) : 38–41. http://dx.doi.org/10.17721/2227-1481.4.38-41.

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We present the results of photometric observations of a dynamically new comet C/2010 S1 (LINEAR), conducted on June 18, 2012. The comet demonstrated a considerable level of physical activity at a heliocentric distance of 6.3 AU. The brightness, measured under a phase angle of 8.9 degrees, was equal to 14.55m ± 0.06m and 14.21m ± 0.04 m in V- and R-bands, respectively. The brightness distribution over the coma was found to be inversely proportional to the projected onto the sky plane nucleocentric distance, with a slope of approximately −1. Therefore, the calculated Afρ parameter, approximately 8400 cm and 8200 cm for V and R filters, respectively, was used to estimate the dust production rate. Assuming a steady outflow of dust particles from the nucleus, the dust production rate was estimated to be between 20 and 60 kg/s, depending on the assumed value of the grain's albedo. The V-R colour index obtained from the near-nucleus region of the coma is in agreement with the solar V-R colour index, and does not indicate significant reddening of the reflected solar radiation in the spectral region of 540-683 nm.

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Qi, Yuhua, Jing Tu, Lunbiao Cui, Xiling Guo, Zhiyang Shi, Shuchun Li, Wenting Shi et al. « High-Throughput Sequencing of MicroRNAs in Adenovirus Type 3 Infected Human Laryngeal Epithelial Cells ». Journal of Biomedicine and Biotechnology 2010 (2010) : 1–8. http://dx.doi.org/10.1155/2010/915980.

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Adenovirus infection can cause various illnesses depending on the infecting serotype, such as gastroenteritis, conjunctivitis, cystitis, and rash illness, but the infection mechanism is still unknown. MicroRNAs (miRNA) have been reported to play essential roles in cell proliferation, cell differentiation, and pathogenesis of human diseases including viral infections. We analyzed the miRNA expression profiles from adenovirus type 3 (AD3) infected Human laryngeal epithelial (Hep2) cells using a SOLiD deep sequencing. 492 precursor miRNAs were identified in the AD3 infected Hep2 cells, and 540 precursor miRNAs were identified in the control. A total of 44 miRNAs demonstrated high expression and 36 miRNAs showed lower expression in the AD3 infected cells than control. The biogenesis of miRNAs has been analyzed, and some of the SOLiD results were confirmed by Quantitative PCR analysis. The present studies may provide a useful clue for the biological function research into AD3 infection.

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Markar, Sheraz, Caroline Gronnier, Alain Duhamel, Arnaud Pasquer, Jérémie Théreaux, Mael Chalret du Rieu, Jérémie H. Lefevre, Kathleen Turner, Guillaume Luc et Christophe Mariette. « Salvage Surgery After Chemoradiotherapy in the Management of Esophageal Cancer : Is It a Viable Therapeutic Option ? » Journal of Clinical Oncology 33, n^o 33 (20 novembre 2015) : 3866–73. http://dx.doi.org/10.1200/jco.2014.59.9092.

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Purpose The aim of this large multicenter study was to assess the impact of salvage esophagectomy after definitive chemoradiotherapy (SALV) on clinical outcome. Patients and Methods Data from consecutive adult patients undergoing resection for esophageal cancer in 30 European centers from 2000 to 2010 were collected. First, groups undergoing SALV (n = 308) and neoadjuvant chemoradiotherapy followed by planned esophagectomy (NCRS; n = 540) were compared. Second, patients who benefited from SALV for persistent (n = 234) versus recurrent disease (n = 74) were compared. Propensity score matching and multivariable analyses were used to compensate for differences in some baseline characteristics. Results SALV versus NCRS groups: In-hospital mortality was similar in both groups (8.4% v 9.3%). The only significant differences in complications were seen for anastomotic leak (17.2% v 10.7%; P = .007) and surgical site infection, which were both more frequent in the SALV group. At 3 years, groups had similar overall (43.3% v 40.1%; P = .542) and disease-free survival (39.2% v 32.8%; P = .232) after matching, along with a similar recurrence pattern. Persistent versus recurrent disease groups: There were no significant differences between groups in incidence of in-hospital mortality or major complications. At 3 years, overall (40.9% v 56.2%; P = .046) and disease-free survival (36.6% v 51.6%; P = .095) were lower in the persistent disease group. Conclusion The results of this large multicenter study from the modern era suggest that SALV can offer acceptable short- and long-term outcomes in selected patients at experienced centers. Persistent cancer after definitive chemoradiotherapy seems to be more biologically aggressive, with poorer survival compared with recurrent cancer.

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Polák, J., et I. Oukropec. « Identification of interspecific peach and Prunus sp. hybrids resistant to Plum pox virus infection ». Plant Protection Science 46, No. 4 (14 décembre 2010) : 139–44. http://dx.doi.org/10.17221/11/2010-pps.

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Interspecific hybrids of Prunus persica, Barier, Fire, Cadaman, GF-677, and Prunus sp. hybrids and selections, MRS, NBS 540-73, and Pumiselect were evaluated for resistance to Plum pox virus. Hybrids were grafted onto trees of a peach cultivar artificially infected with PPV and evaluated for six years for resistance to the virus. The relative concentration of PPV protein was determined by semiquantitative ELISA in June every year. The presence of PPV in peach hybrids was confirmed by IC-RT-PCR in 2007–2008. The presence and intensity of PPV symptoms were evaluated monthly from May to September. The hybrid GF-677 (P. amygdalus × P. persica) was confirmed as highly resistant to PPV. Hybrids Cadaman (P. davidiana × P. persica) and Fire (P. amygdalus × P. persica) were characterized as resistant to PPV. Hybrids GF-677, Cadaman and Fire were selected as candidate sources of resistance to be crossed with peach cultivars susceptible to PPV.

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Mullins, C. Daniel, Kaloyan A. Bikov, Brian S. Seal, Anna Hung et Nader Hanna. « Real-world treatment patterns and the uptake of biologics in elderly medicare patients with metastatic colon cancer. » Journal of Clinical Oncology 33, n^o 3_suppl (20 janvier 2015) : 540. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.540.

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540 Background: Metastatic colon cancer (mCC) patients may receive multiple lines of treatment (Tx1, Tx2, etc.) consisting of one or more cytotoxic (CYT: 5FU/LV, oxaliplatin [OX], irinotecan [IRI]) and biologic (BIO: bevacizumab [BEV], cetuximab [CET], panitumumab [PAN]) drugs. The National Comprehensive Cancer Network (NCCN) provides evidence-based Tx recommendations for each line. The objective of this study was to examine real-world clinical practice patterns between 2002 and 2010. In particular, we compared the most common regimens across Tx lines and how Tx patterns changed over time. We also documented the uptake and use of new BIOs. Methods: We used population-based SEER-Medicare data to determine Tx1, Tx2, and Tx3 regimens of 4,616 mCC patients (the median age at diagnosis was 78) diagnosed in 2003-2009 and followed through 2010. We will use an algorithm previously developed by us to identify regimens. Results: The most common CYT backbone in Tx1 was OX (51% of patients) followed by 5FU/LV (30%). In comparison, IRI was a preferred choice in Tx2 (65%) and Tx3 (31%). In 2003, the most common Tx1 regimens were 5FU/LV- (56%) and IRI-based (35%). 5FU/LV and IRI use decreased to 22% and 9% respectively in 2009, while OX use increased from 7% in 2003 to 63% in 2009. In 2004, the FDA approved BEV for Tx1. BEV’s share increased from 9% in 2004 to 53% in 2005. BEV was used in 9% of Tx2 regimens in 2004 and 46% in 2005. CET was approved in 2004. CET was used in less than 5% of Tx1 regimens in any year up to 2010. CET use in Tx2 increased from 19% to 27% between 2005 and 2007, and declined to 23% in 2010. The FDA approved PAN in September 2006 for treatment after failure of CYT-based regimens, i.e., primarily in Tx3 and beyond. Only 350 (8%) of patients received Tx3, and of these 59 (17%) received PAN without a CYT backbone. One in three Tx3 regimens consisted of biologics only (54% CET, 43% PAN). Conclusions: This study used SEER-Medicare registry data to examine and document real-world clinical practice patterns in treatment of elderly mCC patients between 2003 and 2010. We observed that as new biologic agents were introduced to the market, variations in the combinations and the number of treatment have significantly and rapidly changed.

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Bido, Diógenes de Souza, Dirceu da Silva, Cesar Alexandre de Souza et Arilda Schmidt Godoy. « MENSURAÇÃO COM INDICADORES FORMATIVOS NAS PESQUISAS EM ADMINISTRAÇÃO DE EMPRESAS : COMO LIDAR COM A MULTICOLINEARIDADE ENTRE ELES ? » Administração : Ensino e Pesquisa 11, n^o 2 (30 juin 2010) : 245. http://dx.doi.org/10.13058/raep.2010.v11n2.145.

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O uso de indicadores formativos em modelos de equações estruturais é um dos motivos para se usar o Partial Least Squares Path Modeling (PLSPM) em vez do LISREL. Além disso, tem aumentado o uso de PLS-PM nas pesquisas em Administração de Empresas. O objetivo desta pesquisa é a avaliação dos efeitos da multicolinearidade de indicadores formativos sobre os valores estimados para os pesos fatoriais e para o coeficiente estrutural. Para simular diferentes valores de multicolinearidade varia-se a quantidade de indicadores por variável latente, bem como a correlação entre eles, sendo gerados 540 modelos com diferentes valores para os coeficientes estruturais. Como conclusão, verifica-se que o aumento da variabilidade dos pesos fatoriais é incrementado para valores menores do coeficiente estrutural. Apesar da impossibilidade de se avaliar a importância relativa de cada indicador para a mensuração do construto, sob a influência da multicolinearidade, observa-se que os coeficientes estruturais não são alterados. Também se observa a inconsistência do PLS-PM quando se usa menos de cinco indicadores por variável latente (consistency at large) e quando a confiabilidade é inferior a 0,9. Ao final são feitas recomendações para a minimização dos efeitos da multicolinearidade e sugerem-se direções para novas pesquisas.

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Quadrado, Ellen Regina Sevilla, et Daisy Maria Rizatto Tronchin. « Evaluation of the identification protocol for newborns in a private hospital ». Revista Latino-Americana de Enfermagem 20, n^o 4 (août 2012) : 659–67. http://dx.doi.org/10.1590/s0104-11692012000400005.

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This exploratory-descriptive quantitative study aimed to evaluate the protocol for identifying newborns admitted to the Neonatal Intensive and Semi-intensive Therapy Unit of a private hospital. The case series was made up of 540 observation opportunities, selected by simple random probability sampling. The data was collected between May and August 2010 according to a form and analyzed by descriptive statistic. The protocol's general performance had a conformity index of 82.2%. There were three stages to the protocol: identification components, the identification wristbands' condition and the number of identification wristbands. The highest percentage of conformity (93%) was attributed to the second stage and the lowest (89.3%) to the third, presenting a statistically significant difference of p= 0.046. In the group of 'special' neonates, 88.5% conformity was achieved. These results will make it possible to restructure the protocol for identifying newborns and to establish care and managerial goals so as to improve the quality of care and the patients' safety.

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Sipilanyambe Munyinda, Nosiku, Charles Michelo et Kwenga Sichilongo. « Linking Environmental Exposure with Public Health : Dichlorodiphenyltrichloroethane Extracted from Soils and Water of Recently Exposed Communities of Selected Locations in Zambia ». Journal of Environmental and Public Health 2015 (2015) : 1–8. http://dx.doi.org/10.1155/2015/564189.

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Background. In 2000, a Zambian private mining company reintroduced the use of dichlorodiphenyltrichloroethane (DDT) to control malaria in two districts. From 2000 to 2010, DDT had been applied in homes without any studies conducted to ascertain its fate in the environment. We aimed to quantify the presence of DDT and its metabolites in the soil and water around communities where it was recently used.Methods. We collected superficial soil and water samples from drinking sources of three study areas. DDT was extracted by QuEChERS method and solid phase extraction for soils and water, respectively. Analysis was by gas chromatography-mass spectrometry. A revalidated method with limits of detection ranging from 0.034 to 0.04 ppb was used.Results. Median levels of total DDT were found at 100.4 (IQR 90.9–110) and 725.4 ng/L (IQR 540–774.5) for soils and water, respectively. No DDT above detection limits was detected in the reference area. These results are clinically significant given the persistent characteristics of DDT.Conclusion. DDT presence in these media suggests possible limitations in the environmental safeguards during IRS. Such occurrence could have potential effects on humans, especially children; hence, there is a need to further examine possible associations between this exposure and humans.

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Stanko, Jason P., Rolondo R. Enoch, Jennifer L. Rayner, Christine C. Davis, Douglas C. Wolf, David E. Malarkey et Suzanne E. Fenton. « Corrigendum to “Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats” [Reprod. Toxicol. 30 (2010) 540–549] ». Reproductive Toxicology 32, n^o 1 (juillet 2011) : 146–47. http://dx.doi.org/10.1016/j.reprotox.2011.03.007.

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Resubun, Mariana Lusiana, Enni Dwi Wahyunie et Suria Darma Tarigan. « Analysis Potency of Water Avaibility and Water Demand in Cisangkuy Watershed ». Musamus AE Featuring Journal 2, n^o 1 (6 décembre 2019) : 1–10. http://dx.doi.org/10.35724/maef-j.v2i1.2516.

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Flooding in the rainy season and a drought that occurred in the dry season shows the distribution discharge river that is not evenly throughout the year. The event of floods and droughts happened in Cisangkuy watershed will affect the availability of water in fulfilling 6 important sectors of supporting human life, which is: domestic demand for water, agricultural land for farming, freshwater pounds, farm, industry and maintenance of rivers. Analysis of supply and demand for water in this research aims to review the availability and water demand in Cisangkuy watershed , and also water conservation effort with integrated water management. Methods used in this research is a observation method. The result showed there are scarce water ( deficit) in 2005, 2010 and 2015, each of 76 962 026 m3year-1 111 189 540 m3year-1 and 170 215 063 m3year-1.

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László, Kasik, Vidákovich Tibor, Gáspár Csaba et Tóth Edit. « Az SPSI-A hazai adaptálásának eredményei ». Magyar Pszichológiai Szemle 72, n^o 2 (juin 2017) : 201–29. http://dx.doi.org/10.1556/0016.2017.72.2.4.

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Kutatásunk célja az SPSI—A (Social Problem Solving Inventory—Adolescent, Frauenknecht és Black, 2010) adaptálása volt 12 és 16 évesek körében (N=540). A kérdőív konvergens és diszkriminatív validitásának vizsgálatához az SPSI—R-t (Social Problem Solving Inventory—Revised, D’Zurilla és mtsai, 2002), a Davis által kidolgozott empátiakérdőívet (Interpersonal Reactivity Index, 1980), valamint a Spielberger- féle vonás - és állapotszorongást mérő kérdőívet (State-Trait Anxiety Inventory for Children, Spielberger és mtsai, 1973) használtuk. Az eredeti kérdőív 10 faktoros, 64 kijelentésből áll. A feltáró és a megerősítő faktorelemzés eredményei alapján a magyar változat — SPSI—A(H) – 54 tételt tartalmaz, melyek 11 faktorba csoportosulnak (az eredeti Gondolatok faktor kijelentései elkülönülnek a Pozitív gondolatok és a Negatív gondolatok faktorba). A kérdőív mind a 12, mind a 16 évesek mintáján jó megbízhatósággal (a Cronbach-α sorrendben 0,81 és 0,83) mér. Az eredmények alapján az SPSI—A(H)-t alkalmasnak tartjuk a problémamegoldással kapcsolatos automatikus gondolatok, a problémamegoldáshoz való érzelmi, gondolati viszonyulás, az elkerülés, a probléma meghatározása, a célmeghatározás, az alternatív megoldási módok keresése, a következmények végiggondolása, illetve a nem megfelelő megoldás esetében a gondolatok, teendők újraszervezése és az utólagos kiértékelés mérésére.

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Caspi, Caitlin E., Kathleen Lenk, Jennifer E. Pelletier, Timothy L. Barnes, Lisa Harnack, Darin J. Erickson et Melissa N. Laska. « Food and beverage purchases in corner stores, gas-marts, pharmacies and dollar stores ». Public Health Nutrition 20, n^o 14 (19 septembre 2016) : 2587–97. http://dx.doi.org/10.1017/s1368980016002524.

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Abstract Objective Little is known about customer purchases of foods and beverages from small and non-traditional food retailers (i.e. corner stores, gas-marts, dollar stores and pharmacies). The present study aimed to: (i) describe customer characteristics, shopping frequency and reasons for shopping at small and non-traditional food retailers; and (ii) describe food/beverage purchases and their nutritional quality, including differences across store type. Design Data were collected through customer intercept interviews. Nutritional quality of food/beverage purchases was analysed; a Healthy Eating Index-2010 (HEI-2010) score for purchases was created by aggregating participant purchases at each store. Setting Small and non-traditional food stores that were not WIC-authorized in Minneapolis and St. Paul, MN, USA. Subjects Customers (n 661) from 105 food retailers. Results Among participants, 29 % shopped at the store at least once daily; an additional 44 % shopped there at least once weekly. Most participants (74 %) cited convenient location as the primary draw to the store. Customers purchased a median of 2262 kJ (540 kcal), which varied by store type (P=0·04). The amount of added sugar far surpassed national dietary recommendations. At dollar stores, participants purchased a median of 5302 kJ (1266 kcal) for a median value of $US 2·89. Sugar-sweetened beverages were the most common purchase. The mean HEI-2010 score across all stores was 36·4. Conclusions Small and non-traditional food stores contribute to the urban food environment. Given the poor nutritional quality of purchases, findings support the need for interventions that address customer decision making in these stores.

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Kelesidis, Theodoros, Nikolay Braykov, Daniel Z. Uslan, Daniel J. Morgan, Sumanth Gandra, Birgir Johannsson, Marin L. Schweizer et al. « Indications and Types of Antibiotic Agents Used in 6 Acute Care Hospitals, 2009–2010 : A Pragmatic Retrospective Observational Study ». Infection Control & ; Hospital Epidemiology 37, n^o 1 (12 octobre 2015) : 70–79. http://dx.doi.org/10.1017/ice.2015.226.

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BACKGROUNDTo design better antimicrobial stewardship programs, detailed data on the primary drivers and patterns of antibiotic use are needed.OBJECTIVETo characterize the indications for antibiotic therapy, agents used, duration, combinations, and microbiological justification in 6 acute-care US facilities with varied location, size, and type of antimicrobial stewardship programs.DESIGN, PARTICIPANTS, AND SETTINGRetrospective medical chart review was performed on a random cross-sectional sample of 1,200 adult inpatients, hospitalized (>24 hrs) in 6 hospitals, and receiving at least 1 antibiotic dose on 4 index dates chosen at equal intervals through a 1-year study period (October 1, 2009–September 30, 2010).METHODSInfectious disease specialists recorded patient demographic characteristics, comorbidities, microbiological and radiological testing, and agents used, dose, duration, and indication for antibiotic prescriptions.RESULTSOn the index dates 4,119 (60.5%) of 6,812 inpatients were receiving antibiotics. The random sample of 1,200 case patients was receiving 2,527 antibiotics (average: 2.1 per patient); 540 (21.4%) were prophylactic and 1,987 (78.6%) were therapeutic, of which 372 (18.7%) were pathogen-directed at start. Of the 1,615 empirical starts, 382 (23.7%) were subsequently pathogen-directed and 1,231 (76.2%) remained empirical. Use was primarily for respiratory (27.6% of prescriptions) followed by gastrointestinal (13.1%) infections. Fluoroquinolones, vancomycin, and antipseudomonal penicillins together accounted for 47.1% of therapy-days.CONCLUSIONSUse of broad-spectrum empirical therapy was prevalent in 6 US acute care facilities and in most instances was not subsequently pathogen directed. Fluoroquinolones, vancomycin, and antipseudomonal penicillins were the most frequently used antibiotics, particularly for respiratory indications.Infect. Control Hosp. Epidemiol. 2015;37(1):70–79

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Heredia, Natalia I., MinJae Lee et Belinda M. Reininger. « Hispanic adults’ physical activity and sedentary behavior profiles : examining existing data to drive prospective research ». Journal of Public Health 42, n^o 2 (14 juin 2019) : e120-e125. http://dx.doi.org/10.1093/pubmed/fdz065.

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Abstract Background Because physical activity (PA) and sedentary behavior (SB) are two distinct, interdependent behaviors, increases in PA may influence SB. As a limited number of SB interventions have been tested in Latino/Hispanic samples,. The purpose of this study is to assess if there was more PA and less SB in a Hispanic border community where there had been a PA-targeted community-wide campaign since 2005. Methods This cross-sectional study included Hispanic adults (N = 676) sampled from both intervention and comparison Texas-Mexico border communities in 2010. Our dependent variable was four-categories based on meeting PA guidelines and excessive SB (≥540 mins/day) cut-points. We conducted adjusted multivariable analysis to assess the association of intervention group with the PA/SB groupings. Results In 2010, most adults were in the Low PA/Low SB group. Compared to the comparison group, the intervention group had 6.45 (p < 0.001) times the adjusted odds of being in the High PA/Low SB vs. Low PA/High SB group. Conclusions Five years into the campaign, more PA and less SB were more likely in the intervention community, indicating the association of some PA interventions with SB. PA-targeted interventions should capture effects on SB to expand the literature on effective SB interventions for Hispanic adults.

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Shkhapatsev, Aslan, Valeria Vilkova, Vasiliy Soldatov, Kamil Kazeev et Sergey Kolesnikov. « Decade-long soil changes after the clear felling in forests of the North-Western Caucasus mountains ». SAINS TANAH - Journal of Soil Science and Agroclimatology 20, n^o 1 (3 janvier 2023) : 1. http://dx.doi.org/10.20961/stjssa.v20i1.63187.

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Clear-fell harvesting significantly alters ecosystem attributes at multiple spatial scales. The results of a study of the dynamics of changes in Rendzik Leptosol and Greyic Phaeozem Vertic forests in the middle mountains of the North-Western Caucasus after clear-cutting in 2010-2020 are presented. Immediately after clearing the forest, areas with varying degrees of disturbance of the soil and vegetation cover were identified in the clearings, from maximum disturbance in the central part of the clearing to slight disturbance on their periphery at different elevations of 540-1600 meters above sea level (masl). The soil covering is represented with Rendzik Leptosol and Greyic Phaeozem Vertic. Among used metrics were temperature, humidity, texture density, penetration resistance, structural and aggregate composition, and other soil parameters. On felling areas, increased temperatures and decreased soil humidity were recorded. The temperature of Rendzik Leptosol at a depth of 10-30 cm changes within the range of 1-15°С in the period 2018-2020. The terrain elevation affects the soil due to the temperature gradient significantly. Rendzik Leptosol is much colder at an elevation 1640 meters above sea level than at 1200 meters above sea level. The temperature of Phaeozem (540 meters above sea level) reaches 20°С during the summer months at a depth of 10 cm. Soils in felling have differences in structural and aggregate composition and water resistance of aggregates. The study results can be used in assessing damage to ecosystems after deforestation and developing methods for accelerating the restoration of soil properties after deforestation. The result of the study can be applied to assess the change in the state of ecosystems after forest degradation. The most informative diagnostic indicators for assessing the state of ecosystems after forest degradation are discussed in the article.

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Vick, Erik, Scott Goodwin et Dorota Temple. « Electrical Demonstration of TSV Interconnects and Multilevel Metallization for 3D Si Interposer Applications ». International Symposium on Microelectronics 2010, n^o 1 (1 janvier 2010) : 000007–14. http://dx.doi.org/10.4071/isom-2010-ta1-paper2.

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A TSV test vehicle lot and 3D interposer demonstration lot were successfully fabricated and tested. Fabrication of the TSV test vehicle was accomplished using three process (mask) levels – front-side metal, backside TSV, and backside metal. The TSVs were formed using a vias-last approach with a nominal TSV size of 100μm, and an aspect ratio of 6:1. DRIE bottom clear process conditions were tested which produced 100 % yield on TSV contact chains with up to 540 vias. In addition, optimum process conditions resulted in a TSV resistance of 29 mΩ, and sufficient TSV isolation resistance (> 1MΩ) for the target application. The interposer demonstration lot incorporated five front-side metal levels, one TSV level, and two backside metal levels. The first four metal layers (M1-M4), utilized 2μm Cu and 2μm oxide layers. Metal layers M2-M4 were fabricated using a self-aligned dual damascene process. Each wafer in the demonstration lot had 4 MLM contact chain test structures, with 26400 vias per structure. On two wafers, 100 % yield was achieved on the MLM contact chains. For the dual damascene levels, average contact resistance per via was 4 mΩ. Functional testing was performed on two die from the demonstration lot (die size = 4 cm X 3.7 cm). Over 99 % of the functional nets (circuit paths) passed. Yield on large area test capacitors, tested at wafer level, exceeded 80 %.

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Saunois, Marielle, Philippe Bousquet, Ben Poulter, Anna Peregon, Philippe Ciais, Josep G. Canadell, Edward J. Dlugokencky et al. « The global methane budget 2000–2012 ». Earth System Science Data 8, n^o 2 (12 décembre 2016) : 697–751. http://dx.doi.org/10.5194/essd-8-697-2016.

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Abstract. The global methane (CH4) budget is becoming an increasingly important component for managing realistic pathways to mitigate climate change. This relevance, due to a shorter atmospheric lifetime and a stronger warming potential than carbon dioxide, is challenged by the still unexplained changes of atmospheric CH4 over the past decade. Emissions and concentrations of CH4 are continuing to increase, making CH4 the second most important human-induced greenhouse gas after carbon dioxide. Two major difficulties in reducing uncertainties come from the large variety of diffusive CH4 sources that overlap geographically, and from the destruction of CH4 by the very short-lived hydroxyl radical (OH). To address these difficulties, we have established a consortium of multi-disciplinary scientists under the umbrella of the Global Carbon Project to synthesize and stimulate research on the methane cycle, and producing regular (∼ biennial) updates of the global methane budget. This consortium includes atmospheric physicists and chemists, biogeochemists of surface and marine emissions, and socio-economists who study anthropogenic emissions. Following Kirschke et al. (2013), we propose here the first version of a living review paper that integrates results of top-down studies (exploiting atmospheric observations within an atmospheric inverse-modelling framework) and bottom-up models, inventories and data-driven approaches (including process-based models for estimating land surface emissions and atmospheric chemistry, and inventories for anthropogenic emissions, data-driven extrapolations). For the 2003–2012 decade, global methane emissions are estimated by top-down inversions at 558 Tg CH4 yr−1, range 540–568. About 60 % of global emissions are anthropogenic (range 50–65 %). Since 2010, the bottom-up global emission inventories have been closer to methane emissions in the most carbon-intensive Representative Concentrations Pathway (RCP8.5) and higher than all other RCP scenarios. Bottom-up approaches suggest larger global emissions (736 Tg CH4 yr−1, range 596–884) mostly because of larger natural emissions from individual sources such as inland waters, natural wetlands and geological sources. Considering the atmospheric constraints on the top-down budget, it is likely that some of the individual emissions reported by the bottom-up approaches are overestimated, leading to too large global emissions. Latitudinal data from top-down emissions indicate a predominance of tropical emissions (∼ 64 % of the global budget, < 30° N) as compared to mid (∼ 32 %, 30–60° N) and high northern latitudes (∼ 4 %, 60–90° N). Top-down inversions consistently infer lower emissions in China (∼ 58 Tg CH4 yr−1, range 51–72, −14 %) and higher emissions in Africa (86 Tg CH4 yr−1, range 73–108, +19 %) than bottom-up values used as prior estimates. Overall, uncertainties for anthropogenic emissions appear smaller than those from natural sources, and the uncertainties on source categories appear larger for top-down inversions than for bottom-up inventories and models. The most important source of uncertainty on the methane budget is attributable to emissions from wetland and other inland waters. We show that the wetland extent could contribute 30–40 % on the estimated range for wetland emissions. Other priorities for improving the methane budget include the following: (i) the development of process-based models for inland-water emissions, (ii) the intensification of methane observations at local scale (flux measurements) to constrain bottom-up land surface models, and at regional scale (surface networks and satellites) to constrain top-down inversions, (iii) improvements in the estimation of atmospheric loss by OH, and (iv) improvements of the transport models integrated in top-down inversions. The data presented here can be downloaded from the Carbon Dioxide Information Analysis Center (http://doi.org/10.3334/CDIAC/GLOBAL_METHANE_BUDGET_2016_V1.1) and the Global Carbon Project.

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Zeidan, Gabriela Calvi, Mariane dos Santos Aguiar Luz et Guisla Boehs. « Parasites of economically important bivalves from the southern coast of Bahia State, Brazil ». Revista Brasileira de Parasitologia Veterinária 21, n^o 4 (décembre 2012) : 391–98. http://dx.doi.org/10.1590/s1984-29612012000400009.

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This study investigated the parasites of three commercially important bivalve species (Crassostrea rhizophorae, Mytella guyanensis and Lucina pectinata) from the southern coast of Bahia, Brazil. A total of 540 specimens were collected in August 2009 and February 2010, at three localities. The bivalve specimens were measured on their longest axis, opened, and macroscopically examined for the presence of parasites or signs of disease. They were then fixed in Davidson' solution and subjected to routine histological processing, with paraffin embedding and H&E staining; next, the specimens were examined under a light microscope. No parasites were observed associated with L. pectinata. Rickettsia-like organisms (RLOs), Sphenophrya sp. (Ciliophora), Nematopsis sp. (Apicomplexa), Urastoma sp. (Turbellaria) and Bucephalus sp. (Digenea) were observed in both C. rhizophorae and M. guyanensis, as well as Ancistrocoma sp. (Ciliophora) and Tylocephalum sp. (Cestoda) in the former. A high prevalence of Nematopsis sp. was seen, but caused no apparent damage to the host. Bucephalus sp. caused the destruction of tissues, with castration, but showed low prevalence. The other parasites occurred in low prevalence and intensity, without causing significant damage.

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Kyprianou, Andreas E., Victor Rivero et Weerapat Satitkanitkul. « Deep Factorisation of the Stable Process III : the View from Radial Excursion Theory and the Point of Closest Reach ». Potential Analysis 53, n^o 4 (16 novembre 2019) : 1347–75. http://dx.doi.org/10.1007/s11118-019-09809-4.

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AbstractWe compute explicitly the distribution of the point of closest reach to the origin in the path of any d-dimensional isotropic stable process, with d ≥ 2. Moreover, we develop a new radial excursion theory, from which we push the classical Blumenthal–Getoor–Ray identities for first entry/exit into a ball (cf. Blumenthal et al. Trans. Amer. Math. Soc., 99, 540–554 1961) into the more complex setting of n-tuple laws for overshoots and undershoots. We identify explicitly the stationary distribution of any d-dimensional isotropic stable process when reflected in its running radial supremum. Finally, for such processes, and as consequence of some of the analysis of the aforesaid, we provide a representation of the Wiener–Hopf factorisation of the MAP that underlies the stable process through the Lamperti–Kiu transform. Our analysis continues in the spirit of Kyprianou (Ann. Appl. Probab., 20(2), 522–564 2010) and Kyprianou et al. (2015) in that our methodology is largely based around treating stable processes as self-similar Markov processes and, accordingly, taking advantage of their Lamperti-Kiu decomposition.

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Sanyal, S., et A. Madan. « (P2-39) Public Health Safety for Traditional Mass Gatherings in India : A 10-Year Analysis ». Prehospital and Disaster Medicine 26, S1 (mai 2011) : s148. http://dx.doi.org/10.1017/s1049023x11004833.

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IntroductionIn the past decade, India has witnessed many lapses in crowd safety during mass gatherings. The high casualty rate in stampedes during traditional mass gatherings has prompted the study of these events. Wide variations exist in casualty rates for similar events, and key issues in healthcare services in these special situations were addressed in the Indian context.MethodsFrom 2001–2010, Mass gathering data were collected from news items reported in the archives of newspapers, “The Times of India”, “The Hindu” and “The Indian Express”. The keywords used were: “stampede”, “mass gathering”, “mass-gathering events”, “mass-gathering incidents”, “crowd”, and “crowd management”. The study included triggers for the incident and the number of casualties (dead and injured) in each incident.ResultsIn 27 separate mass gatherings in India, there were 936 dead and 540 injured casualties. The unique characteristics of mass gatherings in India included a predominance of old and vulnerable people in traditional mass gatherings, in contrast to the young and middle-aged groups who gather for music and sporting events elsewhere. Further, alcohol/substance abuse, brawls, and violent behavior were absent at traditional Indian mass gatherings. Non-traditional mass gatherings accounted for a lesser number of incidents in India, and were located in movie theatres and railway stations.ConclusionsIn a populous country like India, traditional mass gatherings predominate, and ensuring the health, safety, and security of the public at such events will require an understanding of crowd behavior, critical crowd densities, and crowd capacities in the Indian context. However, planning for mass gatherings can be developed using the existing body of knowledge of mass-casualty preparedness, food safety, and health promotion.

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MIRI, KHALED, et D. S. RANA. « Evaluation of sweet sorghum (Sorghum bicolor) genotypes for biomass, sugar and ethanol production under different levels of nitrogen ». Indian Journal of Agricultural Sciences 82, n^o 3 (12 mars 2012) : 195–200. http://dx.doi.org/10.56093/ijas.v82i3.15937.

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Sweet sorghum [Sorghum bicolor (L.).Moench] stalks contain high fermentable sugar and thus have potential to produce bio-ethanol along with grains and crushed dry matter. Its cultivars differ in production potential, adaptation, duration and response to nitrogen level under different agro-climatic conditions. A field experiment was conducted at New Delhi, during kharif season of 2009 and 2010 to evaluate three sweet sorghum genotypes (varieties: RSSV 9, SSV 84, and hybrid: CSH 22 SS) under four nitrogen levels (0, 50, 100 and 150 kg N/ha for growth, biomass, fermentable sugar and potential ethanol yield. In the first year, except green biomass, juice yield, fermentable sugar yield and expected ethanol yield recorded significant increase up to 100 kg N/ha, while green biomass yield responded up to 150 kg N/ha. In the second year, all yield parameters except brix (%) showed marked improvement up to 150 kg N/ha. Expected ethanol yield recorded 83.4% and 77.7% increase due to application of 150 kg N/ha over control in 2009 and 2010 respectively. Among the genotypes, hybrid CSH 22 SS showed it’s significant superiority in the above mentioned yield parameters over varieties, except brix (%), which was the highest in RSSV 9. Hybrid CSH 22 SS recorded 112% and 34% increase in ethanol yield over SSV 84 and RSSV 9, respectively. Interaction effect of nitrogen × genotypes for all above characters, except brix (%) was significant. Hybrid CSH 22 SS responded significantly up to 150 kg N/ha, while in case of varieties response to N application was significant only up to 100 kg N/ha. Net return with 150 kg N/ha fertilizer application recorded 116.9 and 116.3% increase over control in 2009 and 2010 respectively. On an average hybrid CSH 22 SS produced net returns of ` 41 540 which was 135 and 41% higher than SSV 84 and RSSV 9 respectively.

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Gallardo Vázquez, Dolores, María Isabel Sánchez Hernández et María Beatriz Corchuelo Martínez-Azúa. « Competencias transversales en el EEES : la opinión del estudiante sobre la importancia y el dominio de una lengua extranjera ». EDUCADE - Revista de Educación en Contabilidad, Finanzas y Administración de Empresas, n^o 1 (2010) : 79–99. http://dx.doi.org/10.12795/educade.2010.i01.06.

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La adaptación al Espacio Europeo de Educación Superior (EEES) conlleva el fomento de la movilidad de docentes y estudiantes. A los profesores les corresponde el importante papel de incentivar a los futuros graduados hacia el dominio de otras lenguas europeas con el fin de que puedan aumentar su competitividad en el mundo laboral. La literatura y la evidencia práctica indican que el nivel de nuestros estudiantes en competencias idiomáticas no alcanza los estándares adecuados para competir. Así, nuestro objetivo ha sido conocer su opinión sobre el dominio que actualmente tienen de una o más lenguas extranjeras así como la importancia que le atribuyen al hecho de conocerla y dominarla. La metodología seguida ha supuesto la realización de varias experiencias y la triangulación de los resultados obtenidos de las mismas, las cuales han consistido en: 1º. Sensibilización a través de una conferencia sobre la importancia del dominio de otras lenguas y su relevancia para la empleabilidad del egresado; 2º. Acercamiento a las impresiones del estudiante que recibe una clase en inglés con un focus group; y, 3º. Análisis de un cuestionario de percepciones sobre dominio e importancia de los idiomas que analiza la opinión del estudiante sobre estos aspectos. Precisamente la evidencia empírica de este estudio proviene de la opinión de los estudiantes de las titulaciones que se impartían en la Facultad de CC.EE.EE. de nuestra Universidad contando con una muestra final de 540 cuestionarios. Los resultados muestran una brecha entre dominio e importancia atribuida que se refuerza cuando se analizan los datos según la movilidad del estudiante. El estudio lleva, finalmente, a realizar un análisis DAFO de debilidades y fortalezas internas, y amenazas y oportunidades externas que determine qué medidas se podrían adoptar para acercar el grado de importancia al grado de dominio.

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Merbold, L., C. Steinlin et F. Hagedorn. « Winter greenhouse gas fluxes (CO2, CH4 ; and N2O) from a subalpine grassland ». Biogeosciences 10, n^o 5 (13 mai 2013) : 3185–203. http://dx.doi.org/10.5194/bg-10-3185-2013.

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Abstract. Although greenhouse gas emissions during winter contribute significantly to annual balances, their quantification is still highly uncertain in snow-covered ecosystems. Here, carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) fluxes were measured at a subalpine managed grassland in Switzerland using concentration gradients within the snowpack (CO2, CH4, N2O) and the eddy covariance method (CO2) during the winter 2010/2011. Our objectives were (1) to identify the temporal and spatial variation of greenhouse gases (GHGs) and their drivers, and (2) to estimate the GHG budget of the site during this specific season (1 December–31 March, 121 days). Mean winter fluxes (December–March) based on the gradient method were 0.77 ± 0.54 μmol m−2 s−1 for CO2 (1.19 ± 1.05 μmol m−2 s−1 measured by eddy covariance), −0.14 ± 0.09 nmol m−2 s−1 for CH4 and 0.23 ± 0.23 nmol m−2 s−1 for N2O, respectively. In comparison with the CO2 fluxes measured by eddy covariance, the gradient technique underestimated the effluxes by 50%. While CO2 and CH4 fluxes decreased with the progressing winter season, N2O fluxes did not follow a seasonal pattern. The major variables correlating with the fluxes of CO2 and CH4 were soil temperature and snow water equivalent, which is based on snow height and snow density. N2O fluxes were only explained poorly by any of the measured environmental variables. Spatial variability across the valley floor was smallest for CO2 and largest for N2O. During the winter season 2010/2011, greenhouse gas fluxes ranged between 550 ± 540 g CO2 m−2 estimated by the eddy covariance approach and 543 ± 247 g CO2 m−2, −0.4 ± 0.01 g CH4 m−2 and 0.11 ± 0.1 g N2O m−2 derived by the gradient technique. Total seasonal greenhouse gas emissions from the grassland were between 574 ± 276 and 581 ± 569 g CO2 eq. m−2, with N2O contributing 5% to the overall budget and CH4 reducing the budget by 0.1%. Cumulative budgets of CO2 were smaller than emissions reported for other subalpine meadows in the Swiss Alps and the Rocky Mountains. Further investigations on the GHG exchange of grasslands in winter are needed in order to (1) deepen our currently limited knowledge on the environmental drivers of each GHG, (2) to thoroughly constrain annual balances, and (3) to project possible changes in GHG flux magnitude with expected shorter and warmer winter periods.

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Vandecrux, Baptiste, Michael MacFerrin, Horst Machguth, William T. Colgan, Dirk van As, Achim Heilig, C. Max Stevens et al. « Firn data compilation reveals widespread decrease of firn air content in western Greenland ». Cryosphere 13, n^o 3 (11 mars 2019) : 845–59. http://dx.doi.org/10.5194/tc-13-845-2019.

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Abstract. A porous layer of multi-year snow known as firn covers the Greenland-ice-sheet interior. The firn layer buffers the ice-sheet contribution to sea-level rise by retaining a fraction of summer melt as liquid water and refrozen ice. In this study we quantify the Greenland ice-sheet firn air content (FAC), an indicator of meltwater retention capacity, based on 360 point observations. We quantify FAC in both the uppermost 10 m and the entire firn column before interpolating FAC over the entire ice-sheet firn area as an empirical function of long-term mean air temperature (Ta‾) and net snow accumulation (c˙‾). We estimate a total ice-sheet-wide FAC of 26 800±1840 km3, of which 6500±450 km3 resides within the uppermost 10 m of firn, for the 2010–2017 period. In the dry snow area (Ta‾≤-19 ∘C), FAC has not changed significantly since 1953. In the low-accumulation percolation area (Ta‾>-19 ∘C and c˙‾≤600 mm w.e. yr−1), FAC has decreased by 23±16 % between 1998–2008 and 2010–2017. This reflects a loss of firn retention capacity of between 150±100 Gt and 540±440 Gt, respectively, from the top 10 m and entire firn column. The top 10 m FACs simulated by three regional climate models (HIRHAM5, RACMO2.3p2, and MARv3.9) agree within 12 % with observations. However, model biases in the total FAC and marked regional differences highlight the need for caution when using models to quantify the current and future FAC and firn retention capacity.

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Košuta, Daniel, Borut Jug et Zlatko Fras. « Prognostic Impact of Nonobstructive Coronary Artery Disease Detected by Coronary Computed Tomographic Angiography ». Angiology 72, n^o 8 (19 mars 2021) : 749–53. http://dx.doi.org/10.1177/0003319721999494.

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Coronary computed tomographic angiography (CCTA) is a promising technique for ruling out coronary artery disease (CAD) in patients with chest pain. We aimed to investigate the prognostic impact of nonobstructive CAD on CCTA. We retrospectively reviewed patients who underwent CCTA between 2010 and 2016 at our institution. We divided them into 3 groups: (1) patients with no CAD, (2) patients with nonobstructive CAD, and (3) patients with obstructive CAD. We investigated the incidence of the primary outcome (combination of death, nonfatal myocardial infarction, unstable angina, and late revascularization). A total of 989 patients were included: 540 patients had CAD, which was obstructive (≥50% stenosis) in 256 cases. During the follow-up period, 99 events occurred (32 [7%] in patients without CAD, 26 [9%] in patients with nonobstructive CAD, and 41 [16%] in patients with obstructive CAD; P < .001). The presence of nonobstructive and obstructive CAD was an independent predictor of events (HR: 2.33 [1.15-4.69], P < .001; and 4.02 [1.98-8.13], P = .019, respectively) compared with no CAD. Nonobstructive CAD on CCTA is associated with a 2-fold increase in risk of coronary events compared with patients with no CAD.

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Mahon, John, Cathal Jack McCarthy, Gerard A. Sheridan, James P. Cashman, John M. O'Byrne et Paddy Kenny. « Outcomes of the Exeter V40 cemented femoral stem at a minimum of ten years in a non-designer centre ». Bone & ; Joint Open 1, n^o 12 (1 décembre 2020) : 743–48. http://dx.doi.org/10.1302/2633-1462.112.bjo-2020-0163.r1.

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Aims The Exeter V40 cemented femoral stem was first introduced in 2000. The largest single-centre analysis of this implant to date was published in 2018 by Westerman et al. Excellent results were reported at a minimum of ten years for the first 540 cases performed at the designer centre in the Exeter NHS Trust, with stem survivorship of 96.8%. The aim of this current study is to report long-term outcomes and survivorship for the Exeter V40 stem in a non-designer centre. Methods All patients undergoing primary total hip arthroplasty using the Exeter V40 femoral stem between 1 January 2005 and 31 January 2010 were eligible for inclusion. Data were collected prospectively, with routine follow-up at six to 12 months, two years, five years, and ten years. Functional outcomes were assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. Outcome measures included data on all components in situ beyond ten years, death occurring within ten years with components in situ, and all-cause revision surgery. Results A total of 829 stems in 745 patients were included in the dataset; 155 patients (20.8%) died within ten years, and of the remaining 664 stems, 648 stems (97.6%) remained in situ beyond ten years. For the 21 patients (2.5%) undergoing revision surgery, 16 femoral stems (1.9%) were revised and 18 acetabular components (2.2%) were revised. Indications for revision in order of decreasing frequency were infection (n = 6), pain (n = 6), aseptic component loosening (n = 3), periprosthetic fracture (n = 3), recurrent dislocation (n = 2), and noise production (ceramic-on-ceramic squeak) (n = 1). One patient was revised for aseptic stem loosening. The mean preoperative WOMAC score was 61 (SD 15.9) with a mean postoperative score of 20.4 (SD 19.3) (n = 732; 88.3%). Conclusion The Exeter V40 cemented femoral stem demonstrates excellent functional outcomes and survival when used in a high volume non-designer centre. Outcomes are comparable to those of its serially validated predecessor, the Exeter Universal stem. Cite this article: Bone Jt Open 2020;1-12:743–748.

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England, James T., Bakul Dalal et Heather A. Leitch. « Frequency of and reasons for paroxysmal nocturnal haemoglobinuria screening in patients with unexplained anaemia ». Journal of Clinical Pathology 71, n^o 4 (14 novembre 2017) : 364–67. http://dx.doi.org/10.1136/jclinpath-2017-204724.

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Referral to hematology for anemia is common. In paroxysmal nocturnal hemoglobinuria (PNH), cells deficient in the glycosylphosphatidyl inositol (GPI) anchor are lysed by complement. Eculizumab improves overall survival and quality of life while reducing hemolysis, transfusion requirements, and thrombosis. We evaluated the frequency of screening for PNH in patients with unexplained anemia. Key clinical features, laboratory data, and investigations were recorded for patients referred for anemia since 2010, without a specific cause found. PNH testing was done by flow cytometry. 540 patients had: anemia not yet diagnosed (NYD, n=318 (including unexplained iron deficiency, n=92; DAT-negative hemolysis, n=9)); anemia of chronic disease, n=173; and pancytopenia NYD, n=49. 82.4% had LDH testing done; 85.0% total bilirubin; 78.7% reticulocyte counts; and 40.6% haptoglobin level; 131 (24.2%) had possible hemolysis. PNH testing was done in 56 (10.4%). Those screened for PNH were more likely to have: younger age (P=0.04); a history of thrombosis (P<0.001); undergone a BMBx (P<0.001); received RBC transfusions (P=0.0018); or evidence of DAT-negative hemolysis (P<0.001). In summary, PNH was tested for in a minority of patients with unexplained anemia (10.4%) despite potential indicators of hemolysis in 24.2%. Increased screening could identify patients who would benefit from treatment and should be considered.

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Markar, Sheraz, Caroline Gronnier, Alain Duhamel, Jean-Yves Mabrut, Jean-Pierre Bail, Nicolas Carrere, Jeremie H. Lefevre, Bernard Meunier, Denis Collet et Christophe Mariette. « Salvage surgery following chemoradiotherapy in management of esophageal cancer : Is it a viable therapeutic option ? Results of a multicenter European study. » Journal of Clinical Oncology 33, n^o 3_suppl (20 janvier 2015) : 109. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.109.

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109 Background: Salvage esophagectomy (SE) has traditionally conferred a high rate of mortality and morbidity in small, monocenter, and old publications. The aim of this large multicenter study was to assess the impact of SE following definitive chemoradiotherapy (SALV) on clinical outcomes. Methods: Data from consecutive adult patients undergoing resection for esophageal cancer in 30 European centers from 2000–2010 were collected. Among this population, the first step was to compare SALV (n=308) and neoadjuvant chemoradiotherapy followed by planned esophagectomy (NCRS group, n=540) groups. The second step was to focus on the SALV group and to compare patients that benefited from SE for persistent (PERS group, n=234) versus recurrent (REC group, n=74) disease. Propensity score matching and multivariable analyses were used to compensate for differences in some baseline characteristics. Results: Comparison of SALV and NCRS groups: In-hospital mortality was similar in both groups (8.4% vs. 9.3%). The only significant differences in complications were seen for anastomotic leak (17.2% vs. 10.7%; P=0.007) and surgical site infection, which were both increased in the SALV group. At 3 years, the groups had similar overall (43.3% vs. 40.1%; P=0.542) and disease-free (39.2% vs. 32.8%; P=0.232) survivals, along-with similar overall (46.8% vs. 47.9%; P=0.829), locoregional (18.8% vs. 15.9%; P=0.544), distant (24.3% vs. 28.1%; P=0.949) and mixed (13.0% vs. 13.5%; P=0.888) tumor recurrence. Comparison of PERS and REC groups: There were no significant differences between the groups in the incidence of in-hospital mortality or major complications, apart from reoperation, which was increased in the PERS group (17.9% vs. 8.1%; P=0.042). Overall (23.4% vs 39.2%, p=0.054) and disease free survivals (21.1% vs37.8%, p=0.070) were lower in the PERS group. Conclusions: The results of this large multi-center study suggest that SE can offer acceptable short and long-term outcomes in experienced centers. Randomized controlled trials are required to validate the SE strategy as a viable option in complete esophageal cancer responders.

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Meng, Shawn, Steve Alderman, Cindy Fraley, Robin Ludy, Fengjie Sun et Nancy Osterbauer. « Identification of Anguina funesta from Annual Ryegrass Seed Lots in Oregon ». Plant Health Progress 13, n^o 1 (janvier 2012) : 5. http://dx.doi.org/10.1094/php-2012-1024-01-rs.

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In 2010, seed galls containing Anguina sp. were isolated from 14 annual ryegrass (Lolium multiflorum) seed lots submitted for phytosanitary testing. To identify the species present, the ITS1 region of the ribosomal DNA of the nematodes from the seed lots was analyzed using a PCR-RFLP method. All nematodes produced a single 540-bp DNA amplicon, which was digested with three restriction enzymes, HaeIII, HinfI, and TaqI. The resulting RFLP patterns matched those of A. funesta. To confirm these results, 525 bp of the DNA amplicon was analyzed by DNA sequencing and BLAST analysis, which verified the sequence was identical to A. funesta (Genbank Accession nos. AF363095, AF363096, and AF363104). Because of the association of A. funesta with Rathayibacter toxicus, a second PCR test was conducted to determine if the bacterium was present in the seed lots. A 200-bp DNA amplicon was amplified from two seed galls, sequenced, and subjected to BLAST analysis. Analysis of the entire DNA sequence failed to identify the bacterium present, although testing by USDA-APHIS verified the bacterium was not R. toxicus. This is the first report of A. funesta in the US; R. toxicus was not found with this detection. Accepted for publication 14 September 2012. Published 24 October 2012.

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Kim, Kyung An, Sung-Ho Her, Kyusup Lee, Ik Jun Choi, Jae-Hwan Lee, Jang Hoon Lee, Sang Rok Lee et al. « Clinical Outcomes of Biodegradable versus Durable Polymer Drug Eluting Stents in Rotational Atherectomy : Results from ROCK Registry ». Journal of Clinical Medicine 11, n^o 21 (23 octobre 2022) : 6251. http://dx.doi.org/10.3390/jcm11216251.

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Background: The aim of this study was to compare the clinical outcomes of biodegradable polymer (BP) versus durable polymer (DP) drug eluting stents (DES) in patients with calcified coronary lesions who underwent rotational atherectomy (RA) and percutaneous coronary intervention (PCI). Methods: This study was based on a multicenter registry which enrolled patients with calcified coronary artery disease who received PCI using RA during between January 2010 and October 2019 from 9 tertiary centers in Korea. The primary outcome was 3-year all-cause mortality, and the secondary outcomes were cardiovascular death and target-lesion failure. Results: A total of 540 patients who underwent PCI using RA were enrolled with a follow-up period of median 16.1 months. From this registry, 272 patients with PCI using DP-DES and 238 patients with BP-SGDES were selected for analysis. PCI with BP-DES was associated with decreased all-cause mortality after propensity score matching (HR 0.414, CI 0.174–0.988) and multivariate Cox regression analysis (HR 0.458, HR 0.224–0.940). BP-DES was also associated with decreased cardiovascular mortality, but there was no difference in TLF between the two groups. Conclusions: BP-DES were associated with favorable outcomes compared to DP-DES in patients undergoing PCI using RA for calcified coronary lesions.

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Jung, Jin, Yeonjoo Seo, Sung-Ho Her, Jae-Hwan Lee, Kyusup Lee, Ki-Dong Yoo, Keon-Woong Moon et al. « Prognostic Impact of Atrial Fibrillation in Patients with Heavily Calcified Coronary Artery Disease Receiving Rotational Atherectomy ». Medicina 59, n^o 10 (11 octobre 2023) : 1808. http://dx.doi.org/10.3390/medicina59101808.

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Background and Objectives: Although both rotational atherectomy (RA) and atrial fibrillation (AF) have a high thrombotic risk, there have been no previous studies on the prognostic impact of AF in patients who undergo percutaneous coronary intervention (PCI) using RA. Thus, the aim of the present study was to determine the prognostic impact of AF in patients undergoing PCI using RA. Materials and Methods: A total of 540 patients who received PCI using RA were enrolled between January 2010 and October 2019. Patients were divided into AF and sinus rhythm groups according to the presence of AF. The primary endpoint was net adverse clinical events (NACEs) defined as a composite outcome of all-cause death, myocardial infarction, target vessel revascularization, cerebrovascular accident, or total bleeding. Results: Although in-hospital adverse events showed no difference between those with AF and those without AF (in-hospital events, 54 (11.0%) vs. 6 (12.2%), p = 0.791), AF was strongly associated with an increased risk of NACE at 3 years (NACE: hazard ratio, 1.880; 95% confidence interval, 1.096–3.227; p = 0.022). Conclusions: AF in patients who underwent PCI using RA was strongly associated with poor clinical outcomes. Thus, more attention should be paid to thrombotic and bleeding risks.

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Gazeau, F., J. P. Gattuso, C. Dawber, A. E. Pronker, F. Peene, J. Peene, C. H. R. Heip et J. J. Middelburg. « Effect of ocean acidification on the early life stages of the blue mussel Mytilus edulis ; ». Biogeosciences 7, n^o 7 (1 juillet 2010) : 2051–60. http://dx.doi.org/10.5194/bg-7-2051-2010.

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Abstract. Several experiments have shown a decrease of growth and calcification of organisms at decreased pH levels. There is a growing interest to focus on early life stages that are believed to be more sensitive to environmental disturbances such as hypercapnia. Here, we present experimental data, acquired in a commercial hatchery, demonstrating that the growth of planktonic mussel (Mytilus edulis) larvae is significantly affected by a decrease of pH to a level expected for the end of the century. Even though there was no significant effect of a 0.25–0.34 pH unit decrease on hatching and mortality rates during the first 2 days of development nor during the following 13-day period prior to settlement, final shells were respectively 4.5±1.3 and 6.0±2.3% smaller at pHNBS~7.8 (pCO2~1100–1200 μatm) than at a control pHNBS of ~8.1 (pCO2~460–640 μatm). Moreover, a decrease of 12.0±5.4% of shell thickness was observed after 15d of development. More severe impacts were found with a decrease of ~0.5 pHNBS unit during the first 2 days of development which could be attributed to a decrease of calcification due to a slight undersaturation of seawater with respect to aragonite. Indeed, important effects on both hatching and D-veliger shell growth were found. Hatching rates were 24±4% lower while D-veliger shells were 12.7±0.9% smaller at pHNBS~7.6 (pCO2~1900 μatm) than at a control pHNBS of ~8.1 (pCO2~540 μatm). Although these results show that blue mussel larvae are still able to develop a shell in seawater undersaturated with respect to aragonite, the observed decreases of hatching rates and shell growth could lead to a significant decrease of the settlement success. As the environmental conditions considered in this study do not necessarily reflect the natural conditions experienced by this species at the time of spawning, future studies will need to consider the whole larval cycle (from fertilization to settlement) under environmentally relevant conditions in order to investigate the potential ecological and economical losses of a decrease of this species fitness in the field.

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Singh-Phulgenda, Sauman, Rishikesh Kumar, Prabin Dahal, Abdalla Munir, Sumayyah Rashan, Rutuja Chhajed, Caitlin Naylor et al. « Post-kala-azar dermal leishmaniasis (PKDL) drug efficacy study landscape : A systematic scoping review of clinical trials and observational studies to assess the feasibility of establishing an individual participant-level data (IPD) platform ». PLOS Neglected Tropical Diseases 18, n^o 4 (16 avril 2024) : e0011635. http://dx.doi.org/10.1371/journal.pntd.0011635.

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Background Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis which can occur after successful treatment of visceral leishmaniasis (VL) and is a public health problem in VL endemic areas. We conducted a systematic scoping review to assess the characteristics of published PKDL clinical studies, understand the scope of research and explore the feasibility and value of developing a PKDL individual patient data (IPD) platform. Methods A systematic review of published literature was conducted to identify PKDL clinical studies by searching the following databases: PubMed, Scopus, Ovid Embase, Web of Science Core Collection, WHO Global Index Medicus, PASCAL, Clinicaltrials.gov, Ovid Global Health, Cochrane Database and CENTRAL, and the WHO International Clinical Trials Registry Platform. Only prospective studies in humans with PKDL diagnosis, treatment, and follow-up measurements between January 1973 and March 2023 were included. Extracted data includes variables on patient characteristics, treatment regimens, diagnostic methods, geographical locations, efficacy endpoints, adverse events and statistical methodology. Results A total of 3,418 records were screened, of which 56 unique studies (n = 2,486 patients) were included in this review. Out of the 56 studies, 36 (64.3%) were from India (1983–2022), 12 (21.4%) from Sudan (1992–2021), 6 (10.7%) were from Bangladesh (1991–2019), and 2 (3.6%) from Nepal (2001–2007). Five (8.9%) studies were published between 1981–1990 (n = 193 patients), 10 (17.9%) between 1991–2000 (n = 230 patients), 10 (17.9%) between 2001–2010 (n = 198 patients), and 31 (55.4%) from 2011 onwards (n = 1,865 patients). Eight (14.3%) were randomised clinical trials, and 48 (85.7%) were non-randomised studies. The median post-treatment follow-up duration was 365 days (range: 90–540 days) in 8 RCTs and 360 days (range: 28–2,373 days) in 48 non-randomised studies. Disease diagnosis was based on clinical criterion in 3 (5.4%) studies, a mixture of clinical and parasitological methods in 47 (83.9%) and was unclear in 6 (10.7%) studies. Major drugs used for treatment were miltefosine (n = 636 patients), liposomal amphotericin B (L-AmB) (n = 508 patients), and antinomy regimens (n = 454 patients). Ten other drug regimens were tested in 270 patients with less than 60 patients per regimen. Conclusions Our review identified studies with very limited sample size for the three major drugs (miltefosine, L-AmB, and pentavalent antimony), while the number of patients combined across studies suggest that the IPD platform would be valuable. With the support of relevant stakeholders, the global PKDL community and sufficient financing, a PKDL IPD platform can be realised. This will allow for exploration of different aspects of treatment safety and efficacy, which can potentially guide future healthcare decisions and clinical practices.

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Tomatis, Stefano, Pietro Mancosu, Giacomo Reggiori, Francesca Lobefalo, Pasqualina Gallo, Nicola Lambri, Lucia Paganini et al. « Twenty Years of Advancements in a Radiotherapy Facility : Clinical Protocols, Technology, and Management ». Current Oncology 30, n^o 7 (22 juillet 2023) : 7031–42. http://dx.doi.org/10.3390/curroncol30070510.

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Background: Hypo-fractionation can be an effective strategy to lower costs and save time, increasing patient access to advanced radiation therapy. To demonstrate this potential in practice within the context of temporal evolution, a twenty-year analysis of a representative radiation therapy facility from 2003 to 2022 was conducted. This analysis utilized comprehensive data to quantitatively evaluate the connections between advanced clinical protocols and technological improvements. The findings provide valuable insights to the management team, helping them ensure the delivery of high-quality treatments in a sustainable manner. Methods: Several parameters related to treatment technique, patient positioning, dose prescription, fractionation, equipment technology content, machine workload and throughput, therapy times and patients access counts were extracted from departmental database and analyzed on a yearly basis by means of linear regression. Results: Patients increased by 121 ± 6 new per year (NPY). Since 2010, the incidence of hypo-fractionation protocols grew thanks to increasing Linac technology. In seven years, both the average number of fractions and daily machine workload decreased by −0.84 ± 0.12 fractions/year and −1.61 ± 0.35 patients/year, respectively. The implementation of advanced dose delivery techniques, image guidance and high dose rate beams for high fraction doses, currently systematically used, has increased the complexity and reduced daily treatment throughput since 2010 from 40 to 32 patients per 8 h work shift (WS8). Thanks to hypo-fractionation, such an efficiency drop did not affect NPY, estimating 693 ± 28 NPY/WS8, regardless of the evaluation time. Each newly installed machine was shown to add 540 NPY, while absorbing 0.78 ± 0.04 WS8. The COVID-19 pandemic brought an overall reduction of 3.7% of patients and a reduction of 0.8 fractions/patient, to mitigate patient crowding in the department. Conclusions: The evolution of therapy protocols towards hypo-fractionation was supported by the use of proper technology. The characteristics of this process were quantified considering time progression and organizational aspects. This strategy optimized resources while enabling broader access to advanced radiation therapy. To truly value the benefit of hypo-fractionation, a reimbursement policy should focus on the patient rather than individual treatment fractionation.

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MacLeod, Norman. « A. T. M. Elewa (ed.) 2010. Morphometrics for Nonmorphometricians. Lecture Notes in Earth Sciences, vol. 124. xii + 367pp. Springer-Verlag. Price £117.00, US$169.00 (HB). ISBN 978 3 540 95852 9. » Geological Magazine 148, n^o 3 (4 février 2011) : 507–8. http://dx.doi.org/10.1017/s0016756811000045.

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Jung, Jin, Sung-Ho Her, Kyusup Lee, Ji-Hoon Jung, Ki-Dong Yoo, Keon-Woong Moon, Donggyu Moon et al. « Impact of Diabetes Duration on Clinical Outcome in Patients Receiving Rotational Atherectomy in Calcified Lesions in Korea—Results from ROCK Registry ». Life 12, n^o 7 (4 juillet 2022) : 993. http://dx.doi.org/10.3390/life12070993.

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There are limited data regarding the clinical impact of diabetes duration for patients with heavy calcified coronary lesions. We sought to determine the clinical impact of diabetes duration on clinical outcomes in patients with heavily calcified lesions who required rotational atherectomy during percutaneous coronary intervention (PCI). A total of 540 diabetic patients (583 lesions) were enrolled between January 2010 and October 2019. Patients were classified into three subgroups: patients with no diabetes mellitus (non-DM), shorter duration (S-DM), and longer duration (L-DM), of which duration was divided at 10 years. During 18 months of follow-up-duration, diabetes duration was significantly associated with the primary outcome. The incidence rate of target-vessel failure (TVF), the primary outcome, was significantly higher in the L-DM group compared with non-DM or S-DM. Among secondary outcomes, any repeat revascularization (RR) was frequently observed in the L-DM compared with other groups. In multivariate analysis, the risk of TVF and any RR was 1.9 times and 2.4 times higher in L-DM than in non-DM, respectively. This study firstly demonstrated that there is an association between a longer DM duration and poor clinical outcomes in patients with severe calcified CAD after PCI. More careful monitoring for recurrence is needed during follow-up in those patients.

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Willis, Valerie. « The Relationship Between Hospital Construction and High-Risk Infant Auditory Function at NICU Discharge : A Retrospective Descriptive Cohort Study ». HERD : Health Environments Research & ; Design Journal 11, n^o 2 (15 décembre 2017) : 124–36. http://dx.doi.org/10.1177/1937586717742123.

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Purpose: To describe the difference in auditory function at neonatal intensive care unit (NICU) discharge between high-risk infant cases exposed to hospital construction during NICU stay and those not exposed. Background: Noise produced by routine NICU caregiving exceeds recommended intensity. As California hospitals undergo construction to meet seismic safety regulations, vulnerable neonates are potentially exposed to even higher levels of noise. Ramifications are unknown. Methods: Retrospective data-based descriptive cohort design was used to compare high-risk infant auditory function at NICU discharge between hospital construction exposed and unexposed groups. Sample size: N = 540 infant cases (243 construction exposed and 297 unexposed controls). Inclusion criteria: Infant cases born and discharged from the study site NICU in the year 2010 (unexposed) and year 2015 (exposed) and received a newborn hearing screening by automated auditory brainstem evoked response (ABER) prior to discharge with results reported. Infant cases excluded: hearing screen results by ABER unavailable, potentially confounding characteristics (congenital infection, major anomalies including cleft lip and/or palate), and transferred into or out of the study site. Instrumentation: ABER. Analysis: descriptive statistics (SPSS Version 24.0), hypothesis testing, correlation, and logistic regression. Results: The difference in auditory function at NICU discharge between high-risk infant cases exposed to hospital construction noise and those unexposed was statistically insignificant, χ2 = 1.666, df = 4, p = .1968, 95% confidence interval [−0.635, 2.570]. Conclusions: More research is needed to better understand whether hospital construction exposure during NICU admission negatively affects high-risk infant auditory function. Findings may catalyze theory development, future research, and child health policy.

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Shang, Yufeng, Weida Wang, Minghui Liu, Xiaoqin Chen, Zhongjun Xia et Fuling Zhou. « Development and Validation of a Risk Assessment Model for Early Infection during the First 3 Months in Patients with Newly Diagnosed Multiple Myeloma ». Blood 136, Supplement 1 (5 novembre 2020) : 29–30. http://dx.doi.org/10.1182/blood-2020-141735.

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PurposeEarly infection was an important cause of mortality in patients with multiple myeloma (MM). The study aimed to assess factors affecting early infection and identify patients with high risk developing infection. MethodsDuring January 2010 to June 2019, patients with MM were analyzed, retrospectively. The data was divided into training and independent validation cohort. The least absolute shrinkage and selection operator (LASSO) regression model was used for data dimension reduction, feature selection, and model building. ResultsOf 745 confirmed MM patients, 540 eligible cases were included in final analyses. In total, 165 patients (30.6%) suffered infections, while 110 patients (20.4%) occurred early infections during the first 3 months after diagnosis. Bacteria and the respiratory tract were the most common pathogen and localization of infection, respectively. In training cohort, PS≥2, HGB<100g/L, β2MG≥6.0mg/L and GLB≥80g/L were identified associated with early infections by LASSO regression. Based on the four factors, an early infection risk model of MM (IRMM) was established to define high- and low-risk groups, which showed significantly different rates of infection (35.3% vs. 9.4%,P<0.001, HR=4.381 [95% CI, 2.802-7.221]). IRMM displayed good discrimination (AUC=0.756) and calibration (P=0.94). ConclusionWe determined risk factors for early infection and established a predictive model to help clinicians identify patients with high-risk infection. It can help clinicians to determine whether to adjust monitoring and treatment strategies, or apply prophylactic interventions to high-risk patients. Disclosures No relevant conflicts of interest to declare.

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Voelker, A. H. L., T. Rodrigues, K. Billups, D. Oppo, J. McManus, R. Stein, J. Hefter et J. O. Grimalt. « Variations in mid-latitude North Atlantic surface water properties during the mid-Brunhes (MIS 9–14) and their implications for the thermohaline circulation ». Climate of the Past 6, n^o 4 (27 août 2010) : 531–52. http://dx.doi.org/10.5194/cp-6-531-2010.

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Abstract. Stable isotope and ice-rafted debris records from three core sites in the mid-latitude North Atlantic (IODP Site U1313, MD01-2446, MD03-2699) are combined with records of ODP Sites 1056/1058 and 980 to reconstruct hydrographic conditions during the middle Pleistocene spanning Marine Isotope Stages (MIS) 9–14 (300–540 ka). Core MD03-2699 is the first high-resolution mid-Brunhes record from the North Atlantic's eastern boundary upwelling system covering the complete MIS 11c interval and MIS 13. The array of sites reflect western and eastern basin boundary current as well as north to south transect sampling of subpolar and transitional water masses and allow the reconstruction of transport pathways in the upper limb of the North Atlantic's circulation. Hydrographic conditions in the surface and deep ocean during peak interglacial MIS 9 and 11 were similar among all the sites with relative stable conditions and confirm prolonged warmth during MIS 11c also for the mid-latitudes. Sea surface temperature (SST) reconstructions further reveal that in the mid-latitude North Atlantic MIS 11c is associated with two plateaus, the younger one of which is slightly warmer. Enhanced subsurface northward heat transport in the eastern boundary current system, especially during early MIS 11c, is denoted by the presence of tropical planktic foraminifer species and raises the question how strongly it impacted the Portuguese upwelling system. Deep water ventilation at the onset of MIS 11c significantly preceded surface water ventilation. Although MIS 13 was generally colder and more variable than the younger interglacials the surface water circulation scheme was the same. The greatest differences between the sites existed during the glacial inceptions and glacials. Then a north – south trending hydrographic front separated the nearshore and offshore waters off Portugal. While offshore waters originated from the North Atlantic Current as indicated by the similarities between the records of IODP Site U1313, ODP Site 980 and MD01-2446, nearshore waters as recorded in core MD03-2699 derived from the Azores Current and thus the subtropical gyre. Except for MIS 12, Azores Current influence seems to be related to eastern boundary system dynamics and not to changes in the Atlantic overturning circulation.

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Lemont, Harvey, et Marc Sabo. « Terbinafine-Associated Taste Disturbance with Normal Taste Threshold Scores ». Journal of the American Podiatric Medical Association 91, n^o 10 (1 novembre 2001) : 540–41. http://dx.doi.org/10.7547/87507315-91-10-540.

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The medical literature reveals numerous reports of transient taste disturbance associated with the use of oral terbinafine. A review of these reports, however, fails to confirm taste disturbances by formal taste testing. In this article, a case of long-standing taste dysfunction in a patient who exhibited normal formal taste thresholds is described. (J Am Podiatr Med Assoc 91(10): 540-541, 2001)

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Camp, Christopher L., Vishal Desai, Stan Conte, Christopher S. Ahmad, Michael Ciccotti, Joshua S. Dines, David W. Altchek, John D’Angelo et Timothy B. Griffith. « Revision Ulnar Collateral Ligament Reconstruction in Professional Baseball : Current Trends, Surgical Techniques, and Outcomes ». Orthopaedic Journal of Sports Medicine 7, n^o 8 (août 2019) : 232596711986410. http://dx.doi.org/10.1177/2325967119864104.

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Background: Ulnar collateral ligament (UCL) reconstruction of the elbow is commonly performed on professional baseball pitchers. Recent reports have suggested that revision rates are on the rise and may be higher than previously thought. Purpose: To provide a comprehensive report on current trends, surgical techniques, and outcomes of revision UCL reconstructions performed on professional baseball pitchers between 2010 and 2016. Study Design: Case series; Level of evidence, 4. Methods: The Major League Baseball Health and Injury Tracking System (HITS) was used to compile records of all revision UCL reconstructions performed on professional baseball pitchers between 2010 and 2016. Player data and outcomes were obtained from HITS, and surgical details were obtained from operative reports. Descriptive statistical analysis was performed on epidemiologic data. Outcomes (return to play [RTP] rates, RTP times, subsequent injuries, and subsequent surgeries) were compared across the most common surgical techniques (docking vs modified Jobe) and graft sources (palmaris longus autograft vs hamstring autograft). Results: A total of 69 professional baseball pitchers underwent revision UCL reconstruction from 2010 to 2016 at an average of 1424 days (47 months) after their primary surgery. A trend was seen toward increasing numbers of revision surgeries over time ( R2 = 0.441; P = .104). The most commonly used tunnel configuration was the modified Jobe technique (n = 41; 59.4%), and the most commonly used graft was hamstring autograft (n = 34; 49.3%). A majority (76.6%) of pitchers achieved RTP, and 55.3% were able to return to the same level of play. Mean time to RTP was 436 days (14.5 months) for players with a palmaris longus autograft versus 540 days (18 months) for those with a hamstring autograft ( P = .108). Further, the mean time to RTP was 423 days (14 months) for the docking technique versus 519 days (17 months) for the modified Jobe technique ( P = .296). Similar rates of subsequent injuries and surgeries were noted between the 2 revision techniques and 2 most commonly used graft constructs. Conclusion: Revision UCL reconstruction showed relatively high RTP rates (77%), but only 55% of players returned to their same level of play. Mean time to RTP was shorter than that found in other, smaller investigations. Although general trends were seen toward decreased time to RTP for the docking technique and palmaris longus autograft, these differences did not reach statistical significance.

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Deitelzweig, Steven, Brett Pinsky, Erin Buysman, Michael Lacey, Dinara Makenbaeva, Daniel Wiederkehr et John Graham. « Type of Bleeding Among Patients with Nonvalvular Atrial Fibrillation in a Large Managed Care Population ». Blood 120, n^o 21 (16 novembre 2012) : 2073. http://dx.doi.org/10.1182/blood.v120.21.2073.2073.

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Abstract Abstract 2073 Background: Risk of bleeding is an important consideration among patients with nonvalvular atrial fibrillation (NVAF), and different anatomical sites may carry greater risk for bleeding. Objective: To describe the incidence of critical anatomical site bleeding events among patients with NVAF in the pre-NOAC (novel oral anticoagulation) era. Methods: Administrative claims data were used for this retrospective study. Adults with healthcare claims related to atrial fibrillation (ICD-9-CM 427.31) between Jan 2005 and Jun 2009 but no evidence of valvular disease were included. Patients were followed until the earliest of death, disenrollment from the health plan, or 30 Jun 2010. Bleeding events in the follow-up period were considered major if they were associated with any of the following: inpatient care, blood transfusion, decreased hemoglobin or hematocrit, physician guided medical or surgical treatment, intracranial bleed, or death. Anatomical bleeding sites were identified based on diagnosis codes. Results: The mean (SD) age of the study sample (N=48,260) was 67 (13) years and 62.2% of the patients were male. Mean (SD) follow-up duration was 802 (540) days (median 673 days). Over 105,419 patient-years, the critical site with the highest rate of major bleeding events was the gastrointestinal tract, followed by intracranial bleeding (TABLE). Conclusions: Gastrointestinal, intracranial, and pericardial bleedings were the most frequently observed major bleedings in the pre-NOAC era. Patients with NVAF have a high rate of major gastrointestinal bleedings. Disclosures: Deitelzweig: Bristol-Myers Squibb/OptumInsight: Research Funding, Speakers Bureau. Pinsky:OptumInsight: Employment. Buysman:OptumInsight: Employment. Lacey:OptumInsight: Employment. Makenbaeva:Bristol-Myers Squibb: Employment, Equity Ownership. Wiederkehr:Pfizer: Employment, Equity Ownership. Graham:Bristol-Myers Squibb: Employment, Equity Ownership.

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Peach, Joe James, et Quoc Thong Le Gia. « A spectral method to the stochastic Stokes equations on the sphere ». ANZIAM Journal 60 (26 juin 2019) : C52—C64. http://dx.doi.org/10.21914/anziamj.v60i0.13987.

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We construct numerical solutions to the stochastic Stokes equations on the unit sphere with additive noise. By characterising the noise as a tangential vector field, the weak formulation is derived and a spectral method is used to obtain a numerical solution. The theory is illustrated through a numerical experiment. References P. Benner and C. Trautwein. Optimal distributed and tangential boundary control for the unsteady stochastic Stokes equations. Technical Report, 2018. URL https://arxiv.org/abs/1809.00911. P. Chen, A. Quarteroni, and G. Rozza. Stochastic optimal Robin boundary control problems of advection-dominated elliptic equations. SIAM J. Numer. Anal., 51(5):27002722, 2013. doi:10.1137/120884158. A. Ciraudo, C. D. Negro, A. Herault, and A. Vicari. Advances in modelling methods for lava flow simulation. Commun. SIMAI Cong., 2:18, 2007. doi:10.1685/CSC06067. W. Freeden and M. Schreiner. Spherical functions of mathematical geosciences. Advances in Geophysical and Environmental Mechanics and Mathematics. Springer-Verlag, 2009. doi:10.1007/978-3-540-85112-7. M. Ganesh and Q. T. L. Gia. A radial basis Galerkin method for spherical surface Stokes equation. ANZIAM J., 52:C56C71, 2011. doi:10.21914/anziamj.v52i0.3921. M. Ganesh, Q. T. L. Gia, and I. H. Sloan. A pseudospectral quadrature method for NavierStokes equations on rotating spheres. Math. Comput., 80:13971430, 2011. doi:10.1090/S0025-5718-2010-02440-8. A. A. Il'in. The NavierStokes and Euler equations on two-dimensional manifolds. Math. USSR Sbornik, 69:559579, 1991. doi:10.1070/sm1991v069n02abeh002116. F. Narcowich, J. Ward, and G. Wright. Divergence-free RBFs on surfaces. J. Fourier Anal. Appl., 13:634663, 2007. doi:10.1007/s00041-006-6903-2. S. S. Sritharan. Optimal control of viscous flow. SIAM, 1998. doi:10.1137/1.9781611971415. D. A. Varshalovich, A. N. Moskalev, and V. K. Khersonskii. Quantum theory of angular momentum. World Scientific, 2008. doi:10.1142/0270.

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Barcellos, Roberto L., Sayonara R. R. M. Lins, Clemente Coelho Jr. et Paulo E. P. F. Travassos. « PROCESSOS SEDIMENTARES SAZONAIS E ANÁLISE DA FRAÇÃO ARENOSA NO SISTEMA AMBIENTAL DO SUESTE, FERNANDO DE NORONHA, ESTADO DE PERNAMBUCO ». Arquivos de Ciências do Mar 50, n^o 1 (14 décembre 2017) : 42. http://dx.doi.org/10.32360/acmar.v50i1.18822.

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O arquipélago de Fernando de Noronha é o topo de uma montanha vulcânica extinta, possui 21 ilhas e está localizado a 540 km de Recife-PE, no Atlântico Sul Equatorial (4°S/32°W). Devido à construção de uma barragem e uma estrada, a principal entrada de água doce para o sistema ambiental da baía do Sueste foi reduzida nos últimos anos, prejudicando o comportamento hidrológico e morfodinâmica da praia. O objetivo da pesquisa é a avaliação da análise da fração arenosa como uma ferramenta para o refinamento de dados sedimentológicos dos sedimentos superficiais do sistema ambiental do Sueste (praia, manguezal, laguna, dunas e baía), localizado no sudeste da ilha principal. Foram coletadas 146 amostras de sedimentos superficiais em sete trabalhos de campo sazonais entre os anos de 2010/2011. Os métodos de pesquisa incluem a análise da fração arenosa, granulométrica, do carbonato de cálcio e da matéria orgânica elementar e isotópica. As amostras coletadas foram, predominantemente, de areia fina, bem a moderadamente selecionadas e bioclásticas, apresentando alto teor carbonático (>90% em 83,5% das amostras). A análise da fração arenosa indicou uma homogeneidade espacial e temporal dos grãos, apresentando predominantemente índices BM de 0,80-0,85 indicando forte influência marinha nos processos sedimentares atuais, sendo composto principalmente de fragmentos de conchas de moluscos e corais. Os valores gerais dos dados obtidos foram também indicados na origem oceânica da matéria orgânica sedimentar (C/N<12 e δ13C>19‰PDB) e nas características erosivas dos perfis praiais.

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Vidal, Erica A. G., Manuel Haimovici et Vivian C. S. Hackbart. « Distribution of paralarvae and small juvenile cephalopods in relation to primary production in an upwelling area off southern Brazil ». ICES Journal of Marine Science 67, n^o 7 (29 juin 2010) : 1346–52. http://dx.doi.org/10.1093/icesjms/fsq080.

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Abstract Vidal, E. A. G., Haimovici, M., and Hackbart, V. C. S. 2010. Distribution of paralarvae and small juvenile cephalopods in relation to primary production in an upwelling area off southern Brazil. – ICES Journal of Marine Science, 67: 1346–1352. The distribution of paralarvae and small juvenile cephalopods sampled by a rectangular midwater trawl (opening area 8 m2) over the continental shelf off Cape Santa Marta Grande, southern Brazil (28°09′S–29°56′S) during spring 1989 is discussed. An intrusion of Brazil Current Tropical Water (22°C; 36.5) separates warm, less-saline water (22°C; 35.2) from cooler, more-saline water (15°C; 36.4). Prevailing northeasterly winds led to upwelling of South Atlantic Central Water over the shelf, promoting high Chl a concentrations. Three species constituted 99% of the 628 cephalopods collected: Illex argentinus (n = 540; 4–40 mm mantle length, ML), Argonauta nodosa (n = 46; 2–19 mm ML), and Loligo sanpaulensis (n = 42, 2–21 mm ML). Segregation of I. argentinus juveniles of similar size suggests school formation as small as 10 mm ML. The presence of mature males along with fertilized female A. nodosa indicates mating early in life. There was a consistent and direct link between high plankton production and high densities of juvenile cephalopods through a short and ecologically efficient food chain. The relationship between production, pycnocline intensity, and the density of paralarvae and juveniles revealed suitable conditions for survival and growth during the upwelling season.

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