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Littérature scientifique sur le sujet « 183/.1 »

Auteur : Grafiati

Publié le 25 juillet 2024

Mis à jour le 30 juillet 2024

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Articles de revues sur le sujet "183/.1"

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Kok, B., A. Mistry, R. Malhotra, J. Burdsall, M. Hall, R. Ransford et A. Milestone. « PTU-183 Sehcat – Cast a Wider Net : Abstract PTU-183 Table 1 ». Gut 62, Suppl 1 (juin 2013) : A123.2—A124. http://dx.doi.org/10.1136/gutjnl-2013-304907.273.

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Soufi, Fouad. « IBLA, Tunisn° 183, t. 62, 1999/1 ». Insaniyat / إنسانيات, n^o 8 (31 août 1999) : 187. http://dx.doi.org/10.4000/insaniyat.8358.

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Fengying Chen, Fengying Chen, et YouYing Di and Guochun Zhang YouYing Di and Guochun Zhang. « Crystal Structure, Theoretical Analyses and Thermodynamic Properties of a Ni(II) Complex Based on ONO Donor Tridentate Acylhydrazone ». Journal of the chemical society of pakistan 45, n^o 1 (2023) : 19. http://dx.doi.org/10.52568/001191/jcsp/45.01.2023.

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A novel complex [Ni(C10H8O5N3)2]and#183;H2Oand#183;(CH3OH) (1) (C10H9O5N3= 2-[(4-nitro- benzoyl)-hydrazone]-propionic acid) has been prepared by reaction of NiCl2 with C10H9O5N3 in mixed solvent of methanol and water. The Ni(II) complex in octahedral geometry was characterized by elemental analysis and X-ray single crystal diffraction. Isothermal titration calorimetry (ITC) was performed to observe the reactions between Ni(II) and C10H9O5N3 in methanol solvents. The results showed that the binding constant (Ka), enthalpy change (ΔH), entropy change (ΔS), and Gibbs free energy change (ΔG) of the system are 5.2and#215;105, -11.82 kJand#183;mol-1, 69.78 Jand#183;mol-1and#183;K-1 and -32.62 kJand#183;mol-1, respectively. In addition, the structure was optimized and frontier molecular orbital (FMO) of (1) were analyzed by B3LYP and HF methods with 6-31g level.

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Дегтяренко, П. Н., A. Ballarino, L. Bottura, С. Ю. Гаврилкин, R. Flukiger, В. С. Круглов, С. Т. Латушкин et al. « Влияние облучения быстрыми протонами с энергией 32 MeV на критические параметры современных композиционных проводов на основе сверхпроводящего соединения Nb-=SUB=-3-=/SUB=-Sn ». Письма в журнал технической физики 43, n^o 12 (2017) : 68. http://dx.doi.org/10.21883/pjtf.2017.12.44710.16495.

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Методами вибрационной магнитометрии проведены исследования изменений электрофизических характеристик нескольких типов современных коммерческих многожильных композиционных проводов на основе сверхпроводящего соединения Nb3Sn при температурах 4.2, 7 и 12 K в магнитных полях до 8 T до и после облучения на циклотроне НИЦ КИ быстрыми протонами с энергией 32 MeV и флюенсами облучения phi t = 3 · 1016, 1· 1017, 3· 1017 и 1· 1018 cm-2. Для всех образцов при флюенсах облучения до phi t = 1 · 1017 cm-2 отмечен рост критической плотности тока, наиболее резко выраженный в сильных магнитных полях и при низких температурах; при флюенсе облучения phi t = 1 · 1018 cm-2 наблюдается падение критической плотности тока до уровня меньше исходного. Критическая температура образцов монотонно уменьшается с ростом флюенса облучения. DOI: 10.21883/PJTF.2017.12.44710.16495

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Елисеев, И. Е., А. Н. Юденко, Н. А. Беседина, А. Б. Улитин, В. М. Екимова, С. Р. Евдокимов, Ю. В. Путинцева et al. « Термодинамический анализ стабильности структуры однодоменного терапевтического антитела ». Письма в журнал технической физики 43, n^o 23 (2017) : 86. http://dx.doi.org/10.21883/pjtf.2017.23.45280.17022.

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Стабильность нового однодоменного терапевтического антитела к рецептору ErbB3 исследована методом спектроскопии флуоресценции при различных концентрациях денатурирующего вещества и температуре. Анализ экспериментальных кривых денатурации позволил построить полную термодинамическую модель процесса денатурации и определить все параметры перехода: Delta G = 8.5 kcal · mol-1, Tm = 76oC, Delta Hm= = 107 kcal· mol-1, Delta Cp = 1.8 kcal· K-1· mol-1. Полученные данные свидетельствуют о высокой стабильности антитела в широком диапазоне условий, что чрезвычайно важно для дальнейших структурно-функциональных исследований и возможного терапевтического применения. DOI: 10.21883/PJTF.2017.23.45280.17022

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Tang, Xiaoli, Dong Zheng, Ping Hu, Zongyue Zeng, Ming Li, Lynne Tucker, Renee Monahan, Murray B. Resnick, Manran Liu et Bharat Ramratnam. « Glycogen synthase kinase 3 beta inhibits microRNA-183-96-182 cluster via the β-Catenin/TCF/LEF-1 pathway in gastric cancer cells ». Nucleic Acids Research 42, n^o 5 (12 décembre 2013) : 2988–98. http://dx.doi.org/10.1093/nar/gkt1275.

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Abstract Glycogen synthase kinase 3 beta (GSK3β) is a critical protein kinase that phosphorylates numerous proteins in cells and thereby impacts multiple pathways including the β-Catenin/TCF/LEF-1 pathway. MicroRNAs (miRs) are a class of noncoding small RNAs of ∼22 nucleotides in length. Both GSK3β and miR play myriad roles in cell functions including stem cell development, apoptosis, embryogenesis and tumorigenesis. Here we show that GSK3β inhibits the expression of miR-96, miR-182 and miR-183 through the β-Catenin/TCF/LEF-1 pathway. Knockout of GSK3β in mouse embryonic fibroblast cells increases expression of miR-96, miR-182 and miR-183, coinciding with increases in the protein level and nuclear translocation of β-Catenin. In addition, overexpression of β-Catenin enhances the expression of miR-96, miR-182 and miR-183 in human gastric cancer AGS cells. GSK3β protein levels are decreased in human gastric cancer tissue compared with surrounding normal gastric tissue, coinciding with increases of β-Catenin protein, miR-96, miR-182, miR-183 and primary miR-183-96-182 cluster (pri-miR-183). Furthermore, suppression of miR-183-96-182 cluster with miRCURY LNA miR inhibitors decreases the proliferation and migration of AGS cells. Knockdown of GSK3β with siRNA increases the proliferation of AGS cells. Mechanistically, we show that β-Catenin/TCF/LEF-1 binds to the promoter of miR-183-96-182 cluster gene and thereby activates the transcription of the cluster. In summary, our findings identify a novel role for GSK3β in the regulation of miR-183-96-182 biogenesis through β-Catenin/TCF/LEF-1 pathway in gastric cancer cells.

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Ke, Ke, Ok-Joo Sul, Monisha Rajasekaran et Hye-Seon Choi. « MicroRNA-183 increases osteoclastogenesis by repressing heme oxygenase-1 ». Bone 81 (décembre 2015) : 237–46. http://dx.doi.org/10.1016/j.bone.2015.07.006.

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Ramirez-Cardona, M., J. C. Escamilla-Casas, M. A. Cuevas-Diarte et I. Barajas-Rosales. « Structure determination of 1-pentanol (C5H12O) at 183 K ». Zeitschrift für Kristallographie Supplements 2006, suppl_23_2006 (juin 2006) : 601–6. http://dx.doi.org/10.1524/zksu.2006.suppl_23.601.

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Nguyen, Mai Thi, Kyung-Ho Min et Wan Lee. « MiR-183-5p Induced by Saturated Fatty Acids Hinders Insulin Signaling by Downregulating IRS-1 in Hepatocytes ». International Journal of Molecular Sciences 23, n^o 6 (10 mars 2022) : 2979. http://dx.doi.org/10.3390/ijms23062979.

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Excessive saturated fatty acids (SFA) uptake is known to be a primary cause of obesity, a widely acknowledged risk factor of insulin resistance and type 2 diabetes. Although specific microRNAs (miRNAs) targeting insulin signaling intermediates are dysregulated by SFA, their effects on insulin signaling and sensitivity are largely unknown. Here, we investigated the role of SFA-induced miR-183-5p in the regulation of proximal insulin signaling molecules and the development of hepatic insulin resistance. HepG2 hepatocytes treated with palmitate and the livers of high-fat diet (HFD)-fed mice exhibited impaired insulin signaling resulting from dramatic reductions in the protein expressions of insulin receptor (INSR) and insulin receptor substrate-1 (IRS-1). Differential expression analysis showed the level of miR-183-5p, which tentatively targets the 3′UTR of IRS-1, was significantly elevated in palmitate-treated HepG2 hepatocytes and the livers of HFD-fed mice. Dual-luciferase analysis showed miR-183-5p bound directly to the 3′UTR of IRS-1 and reduced IRS-1 expression at the post-transcriptional stage. Moreover, transfection of HepG2 hepatocytes with miR-183-5p mimic significantly inhibited IRS-1 expression and hindered insulin signaling, consequently inhibiting insulin-stimulated glycogen synthesis. Collectively, this study reveals a novel mechanism whereby miR-183-5p induction by SFA impairs insulin signaling and suggests miR-183-5p plays a crucial role in the pathogenesis of hepatic insulin resistance in the background of obesity.

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Yang, Cheng-Liang, Xiao-Li Zheng, Ke Ye, Hong Ge, Ya-Nan Sun, Yu-Fei Lu et Qing-Xia Fan. « MicroRNA-183 Acts as a Tumor Suppressor in Human Non-Small Cell Lung Cancer by Down-Regulating MTA1 ». Cellular Physiology and Biochemistry 46, n^o 1 (2018) : 93–106. http://dx.doi.org/10.1159/000488412.

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Backgrounds/Aims: MicroRNAs (miRs) often contribute to the progression of non-small cell lung cancer (NSCLC) via regulation of mRNAs that are involved in lung homeostasis. We conducted a study aimed at exploring the roles of miR-183 in the proliferation, epithelial-mesenchymal transition (EMT), invasion and migration of human NSCLC cells via targeting MTA1. Methods: NSCLC and adjacent normal tissues were collected from 194 patients with NSCLC. Positive expression of MTA1 protein was detected by immunohistochemistry. The highest levels of expression of miR-183 were detected using RT-qPCR in SPC-A-1 cells, which were selected and assigned to the following groups: blank, negative control (NC), miR-183 mimic, miR-183 inhibitor, siRNA-MTA1, and miR-183 inhibitor + siRNA-MTA1. The expression of miR-183 and the mRNA and protein expression of MTA1, E-cadherin, Vimentin, Snail, PCNA, Bax and Bcl-2 in tissues and transfected cells were measured using RT-qPCR and western blot analysis. Cell proliferation, apoptosis, migration and invasion were evaluated by CCK-8, flow cytometry, scratch tests and Transwell assays. Tumor xenografts were conducted in nude mice to determine tumor growth. Results: SPC-A-1 cells with the highest levels of miR-183 expression were selected. Compared with adjacent normal tissues, the expression of miR-183 and the mRNA and protein expression of E-cadherin and Bax were decreased in NSCLC tissues, while mRNA and protein expression of MTA1, Vimentin, snail, PCNA and Bcl-2 were increased. MiR-183 was over-expressed in the miR-183 mimic group and under-expressed in the miR-183 inhibitor and miR-183 inhibitor + siRNA-MTA1 groups. In the miR-183 mimic and siRNA-MTA1 groups, the mRNA and protein expression of E-cadherin and Bax, as well as cell apoptosis, were enhanced, while the expression levels of MTA1, Vimentin, snail, PCNA and Bcl-2 mRNA and protein, cell proliferation, migration, invasion and tumor growth were reduced relative to the blank and NC groups. The miR-183 inhibitor group exhibited an opposite trend. Conclusion: Our study indicates that miR-183 down-regulates MTA1 to inhibit the proliferation, EMT, migration and invasion of human NSCLC cells.

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Thèses sur le sujet "183/.1"

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Pease, García Yrigoyen Franklin. « AntropologÍa andina, Nos., 1 y 2, Cuzco 1976, Centro de Estudios Andinos- Cuzco;183 págs ». Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/121497.

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Vieira, Leandro Costa. « Escola experimental de tempo integral e gestão democrática : um estudo do cotidiano escolar ». Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/183.

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A pesquisa aqui apresentada retrata aspectos do cotidiano de uma comunidade escolar no Município de Corumbá, Estado do Mato Grosso do Sul. Tendo como objetivo central identificar as estratégias e articulações referentes à gestão democrática, constituída a partir das relações entre escola e comunidade, presentes na construção e no desenvolvimento de ações pedagógicas no Programa Especial de Educação Integral de Corumbá. Considerou-se pertinente, na realização da pesquisa, o Estudo do Cotidiano Escolar como metodologia para as interpretações referentes ao espaço de ocupação pelos sujeitos da comunidade escolar. Tendo como base teórica e epistemológica de pesquisa autores tais quais: Certeau (2014); Azevedo (2002-2003); Alves e Oliveira (2001, 2002); dentre outros que colaboram com estas obras, referindo-se ao estudo do cotidiano escolar. Para o embasamento teórico sobre gestão democrática e Educação Integral, buscaram-se referenciais em Moll (2000, 2012); Freire (1996, 2011, 2012, 2014); Arroyo (2011, 2012); Silva; Silva (2012); e outros autores relacionados ao tema. A pesquisa empírica deu-se a partir de observações, anotações em diário de campo, conversas e entrevistas com os sujeitos da escola e da comunidade do bairro, articulando teoria e prática como elementares no processo construto da pesquisa, evidenciando como tem se dado o processo democrático da escola, evidenciado a partir de três categorias: Democracia, Poder e Participação. Dos dados coletados, categorizados e analisados, encontram-se os resultados evidenciados a partir das interpretações sobre o modo como a comunidade escolar percebe o processo democrático na sua conjuntura mais ampla. Priorizou-se um olhar mais atento às ações referentes à formação, numa perspectiva emancipadora, capaz de promover a autonomia dos sujeitos envolvidos no processo educativo e, ainda, a formação integral e integrada dos educandos para a vida. O que se pode considerar é que há um discurso de democracia que não se efetiva na prática. A comunidade não participa democraticamente das decisões mais importantes da gestão. Constatou-se que há um movimento de gestão e organização do trabalho escolar verticalizado, embora se tenham algumas estratégias de participação que revelam muito mais um jogo de poder e de manipulação
The research presented here depicts everyday aspects of a school community in the Municipality of Corumbá, Mato Grosso do Sul. With the main objective to identify the strategies and joints related to democratic administration made up of the relationships between school and community, present in the construction and development of educational activities in the Special Program of Integral Education Corumbá. It was considered relevant in conducting the research, the study of the School Daily life as a relevant methodology for the interpretations regarding the occupation of space by the subjects of the school community. With the epistemological theoretical basis of research which authors such: Certeau (2014); Azevedo (2002-2003); Alves and Oliveira (2001, 2002) among other authors who work in these works, referring to the study of everyday school life. For the theoretical foundation in democratic management and Integral Education sought to references in Moll (2000, 2012); Freire (1996, 2011, 2012, 2014); Arroyo (2011, 2012); Silva; Silva (2012) and others related to the topic. The empirical research was made from observations, notes in a field diary, conversations and interviews with the subjects of the school and the neighborhood community, linking theory and practice as a basic construct in the process of research, showing how has given the democratic process school evidenced from three categories: Democracy; Power and Participation. The data collected, categorized and analyzed are the results shown from interpretations of how the school community realizes the democratic process in its broadest context. Prioritized a closer look to the actions relating to training in a liberating perspective, able to promote the autonomy of the subjects involved in the educational process, and also the full and integrated training of students for life. What can be considered is that there is a discourse of democracy which is not effective in practice. The community does not participate democratically the most important decisions of management, it was found that there is a movement of management and organization of vertical school work, although there are some strategies of participation that reveal much more a game of power and handling

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Koda, Fábio. « Estudo da fadiga de contato em engrenagens cilíndricas de dentes retos ». Universidade Tecnológica Federal do Paraná, 2009. http://repositorio.utfpr.edu.br/jspui/handle/1/183.

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Devido à resistência dos fabricantes de automóveis quanto à utilização de engrenagens de FNA estudos tem sido feitos para averiguar o desempenho deste material em engrenagens. Dentro deste contexto esta dissertação tem como objetivos principais o desenvolvimento e construção de uma máquina de ensaios de fadiga de contato em engrenagens e a comparação quanto à resistência ao desgaste de engrenagens cilíndricas de dentes retos fabricadas em aço liga 8620 (cementado e temperado) e em ferro fundido nodular austêmperado (FNA). Estas engrenagens foram fornecidas em dois estados de acabamento superficial (shaving ou por fresamento). O equipamento desenvolvido funciona com o princípio de recirculação de potência e é comumente chamado de FZG. Os experimentos de desgaste têm sido feitos com dois estágios de torque: 135 N.m (running-in) e 302 N.m (steady-state) e as engrenagens são de perfil modificado. Após a realização dos ensaios, foi possível verificar que: (1) a área danificada dos flancos, devido ao fenômeno de pitting, das engrenagens de FNA foi maior do que das de aço AISI 8620; (2) a comparação entre os parâmetros de rugosidade nos estágio de fornecimento e após cada estágio do experimento mostra que as engrenagens com acabamento por shaving apresentam uma melhor distribuição da carga e um menor desgaste, (3) o regime de lubrificação na região do diâmetro primitivo durante os ensaios foi o limite (ou limítrofe) para ambos os processos de fabricação, porém o parâmetro de espessura de filme (λ) é maior para engrenagens fabricadas por shaving, fazendo com que a espessura do filme lubrificante seja maior, (4) o efeito da redução da área resistente aos esforços de contato, devido à presença dos nódulos de grafita, na resistência a fadiga foi evidenciado, porém o acabamento superficial mostrou-se mais relevante do que a distribuição e tamanho dos nódulos.
Due to the resistance of automotive manufactures on apply ADI gear studies have been made to verify the performance of this material. Inside this context this work has a main objective the construction of contact fatigue test machine in gears and the comparison, related to the wear resistance, between spur-gears made of carburized and quenched AISI 8620 low steel and austempered ductile iron (ADI). These gears were supplied in two states of finish surface (by shaving or by machining). The developed equipment functions with the principle of the power recirculation and commonly called FZG. The wear experiments were performed in two stages of torque: 135 N.m (running-in) and 302 N.m (steady-state) and the gears have modified profile. After the accomplishment of the experiments, was possible verify that: (1) The damaged area of flanks, due to the phenomenon of pitting, at ADI gears was bigger than AISI 8620 low-alloy steel gears. (2) The comparisons between the roughness parameter in the supply state and after each period of the experiment shows that gears with surface finish by shaving have better load distribution and minor wear. (3) Lubricant regime at pitch diameter was the boundary for both manufacture process, but the film thickness parameter λ is higher for shaved gears, making the lubricant film thickness has major value, (4) The reduction effect the resistive area of contact due the presence of the graphite nodules in the contact fatigue resistance was evidenced, however surface finishing was more relevant than the distribution and size nodules.

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Barbosa, Viviane de Oliveira. « Mulheres do babaçu : gênero, maternalismo e movimentos sociais no Maranhão ». reponame:Repositório Institucional da UFF, 2013. https://appdesenv.uff.br/riuff/handle/1/183.

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O presente trabalho trata de histórias de mulheres quebradeiras de coco babaçu no Maranhão, no que se referem a representações sociais, relações de trabalho, gênero e maternalismo, construção de identidades, problemas agrários e ambientais, modelos e mecanismos de organização e constituição de movimento social. Este trabalho estrutura-se em alguns eixos básicos e complementares de investigação. Destaca a importância de uma economia doméstica do babaçu amparada no trabalho feminino, analisando as representações sociais desse recurso natural e evidenciando a invisibilidade dos extrativistas diante dos setores dominantes. Analisa as relações de gênero e trabalho e os usos do tempo entre camponeses maranhenses envolvidos com a agricultura e a quebra do coco, apontando para sinais de maternalismo nos discursos e nas práticas das quebradeiras de coco. Aborda também experiências de quebradeiras de cocoque, com ou sem a participação de outros agentes e grupos, construíram identidades coletivas e desenvolveram estratégias de mobilização e formas de resistência num contexto de conflitos e lutas pela terra e pelo acesso e preservação dos babaçuais. E percorre, ainda, o processo de construção da identidade de quebradeira de coco e outras identidades a ela relacionadas (“mulher”, “negra” “quilombola”, “indígena” etc.), analisando conquistas e mudanças na trajetória de mulheres extrativistas depois de sua inserção no MIQCB, inclusive no tocante à ampliação de sua autonomia e na construção de ideais de igualdade de gênero.
This work analyzes stories of babassu coconut breaker’s women in Maranhão, in referring to social representations, labor relations, gender and maternalism, identity construction, agricultural and environmental problems, models and mechanisms of organization and formation and social movement. This work is divided into basic and supplementary axes of research. It highlights the importance of a domestic economy of babassu supported in female work, analyzing the social representations of this natural resource and highlighting the invisibility of peasants in face of a dominant sectors. It analyses gender relations and work, and the uses of time between peasants involved with agriculture and the breaking of coconut in Maranhão, pointing to signs of maternalism in the discourses and practices of coconut breakers. It also discusses the experiences of coconut breakers that with or without the participation of other agents and groups, constructed collective identities and developed mobilization strategies and forms and resistance in the context of conflicts and strugless over land and access and preservation to babassu palm. And, it observes also the process of construction of coconut breaker’s identity and other identities related to it (“woman”, “black”, “maroon”, “indigenous”, etc.) , analyzing changes and achievements in the trajectory of women after their insertion in MIQCB, including the expansion of their autonomy and the construction of ideals of gender equality.

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Dal, Maso Carlo. « Essays in applied econometrics ». Thesis, IMT Alti Studi Lucca, 2016. http://e-theses.imtlucca.it/183/1/DalMaso_phdthesis.pdf.

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Intense political debate surrounded the Italian university system in the last ten years. The latter was widely perceived as auto-referential and inefficient so that each government proposed its own solutions and reforms. These targeted the number of classes offered, the way professors are recruited as well as parameters and amount of public funding toward universities. The present dissertation investigates how interventions affected Italian professors. The first work look at recruitment through the lens of game theory and represent the selection process as a bargain between members of the evaluation committee over the possible candidates. We bring the model to the data and evaluate how the reform of selection rules affected some of the parameters of the model. The second essay, focus on the funding system and in particular on the norms that limit personnel expenses of universities. We exploit the variation of budget constraints in time and across institutions in a quasi-experimental framework and estimate the effect of staff turn over limits on the probability of voluntary leaving academia. Finally, the last work looks directly into the political process and studies the formation and break of coalitions in the Italian parliament through concepts of complex network literature. Chapter 2 A common observation is that individuals strive to neutralize the effect of procedural rules designed to drive choices away from their private optimum. An example of this phenomenon is offered by the reaction of Italian academia to two reforms that modified the procedures of recruitment and promotion, by introducing random selection of the examiners not appointed by the recruiting school and reducing from two to one the number of candidates to be qualified. We model the negotiation occurring within evaluation committees and test the decision rule implied by the theoretical model on the sample composed of all selections to associate and full professorship initiated by the Italian schools of economics between 2004 and 2011. Particularly, we investigate whether these reforms decreased the relative weight of the examiner appointed by the recruiting school on committee’s decision. Empirical results suggest that both reforms had little if no effect on examiners’ weights. Chapter 3 The number of professors employed in Italian universities dropped by 15% between 2008 and 2013. This resulted from two opposite trends: a reduction in new hires and an increment in professors leaving academia. While the first trend can be easily explained by government limits on personnel expenses the second one deserves further explanations. In this paper we investigate whether budget constrains on personnel expenses backfired by pushing Italian professor to quit their positions for private companies or foreign institutions. We exploit the selectivity of the new regulation along with its time variation in a quasi-experimental framework. Results indicate an increase in voluntary leaves among institutions with more severe staff limitations. Surprisingly the latter show lower voluntary leaves on average in both pre and post reform periods. We provide some explanations for these results and point out the limits of our methodologies for future investigations. Chapter 4 We analyze the network of relations between parliament members according to their voting behavior. In particular, we examine the emergent community structure with respect to political coalitions and government alliances. We rely on tools developed in the Complex Network literature to explore the core of these communities and use their topological features to develop new metrics for party polarization, internal coalition cohesiveness and government strength. As a case study, we focus on the Chamber of Deputies of the Italian Parliament, for which we are able to characterize the heterogeneity of the ruling coalition as well as parties specific contributions to the stability of the government over time. We find sharp contrast in the political debate which surprisingly does not imply a relevant structure based on establised parties. We take a closer look to changes in the community structure after parties split up and their effect on the position of single deputies within communities. Finally, we introduce a way to track the stability of the government coalition over time that is able to discern the contribution of each member along with the impact of its possible defection. While our case study relies on the Italian parliament, whose relevance has come into the international spotlight in the present economic downturn, the methods developed here are entirely general and can therefore be applied to a multitude of other scenarios.

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Rossi, Lara <1979&gt. « Il nucleotide extracellulare UTP : induzione della migrazione di cellule staminali emopoietiche CD34+ ». Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/183/1/Tesi_dottorato_Ematologia_2007_-_Lara_Rossi.pdf.

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La letteratura scientifica degli ultimi anni si è arricchita di un numero sempre crescente di studi volti a chiarire i meccanismi che presiedono ai processi di homing di cellule staminali emopoietiche e del loro attecchimento a lungo termine nel midollo osseo. Tali fenomeni sembrano coinvolgere da un lato, l’interazione delle cellule staminali emopoietiche con la complessa architettura e componente cellulare midollare, e dall’altro la riposta ad un’ampia gamma di molecole regolatrici, tra le quali chemochine, citochine, molecole di adesione, enzimi proteolitici e mediatori non peptidici. Fanno parte di quest’ultimo gruppo anche i nucleotidi extracellulari, un gruppo di molecole-segnale recentemente caratterizzate come mediatori di numerose risposte biologiche, tra le quali l’allestimento di fenomeni flogistici e chemiotattici. Nel presente studio è stata investigata la capacità dei nucleotidi extracellulari ATP ed UTP di promuovere, in associazione alla chemochina CXCL12, la migrazione di cellule staminali umane CD34+. E’ così emerso che la stimolazione con UTP è in grado di incrementare significativamente la migrazione dei progenitori emopoietici in risposta al gradiente chemioattrattivo di CXCL12, nonché la loro capacità adesiva. Le analisi citofluorimetriche condotte su cellule migranti sembrano inoltre suggerire che l’UTP agisca interferendo con le dinamiche di internalizzazione del recettore CXCR4, rendendo così le cellule CD34+ maggiormente responsive, e per tempi più lunghi, al gradiente attrattivo del CXCL12. Saggi di homing competitivo in vivo hanno parallelamente mostrato, in topi NOD/SCID, che la stimolazione con UTP aumenta significativamente la capacità dei progenitori emopoeitci umani di localizzarsi a livello midollare. Sono state inoltre indagate alcune possibili vie di trasduzione del segnale attivate dalla stimolazione di recettori P2Y con UTP. Esperimenti di inibizione in presenza della tossina della Pertosse hanno evidenziato il coinvolgimento di proteine Gαi nella migrazione dipendente da CXCL12 ed UTP. Ulteriori indicazioni sono provenute dall’analisi del profilo trascrizionale di cellule staminali CD34+ stimolate con UTP, con CXCL12 o con entrambi i fattori contemporaneamente. Da questa analisi è emerso il ruolo di proteine della famiglia delle Rho GTPasi e di loro effettori a valle (ROCK 1 e ROCK 2) nel promuovere la migrazione UTP-dipendente. Questi dati sono stati confermati successivamente in vitro mediante esperimenti con Tossina B di C. Difficile (un inibitore delle Rho GTPasi) e con Y27632 (in grado di inibire specificatamente le cinasi ROCK). Nel complesso, i dati emersi in questo studio dimostrano la capacità del nucleotide extracellulare UTP di modulare la migrazione in vitro di progenitori emopoietici umani, nonché il loro homing midollare in vivo. L’effetto dell’UTP su questi fenomeni si esplica in concerto con la chemochina CXCL12, attraverso l’attivazione concertata di vie di trasduzione del segnale almeno parzialmente condivise da CXCR4 e recettori P2Y e attraverso il reclutamento comune di proteine ad attività GTPasica, tra le quali le proteine Gαi e i membri della famiglia delle Rho GTPasi.

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Zanella, Caterina. « Nanocomposite coatings produced by electrodeposition from additive-free bath : the potential of the ultrasonic vibrations ». Doctoral thesis, University of Trento, 2010. http://eprints-phd.biblio.unitn.it/183/1/doctoral_thesys_Zanella.pdf.

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The main objectives of this Ph.D. research work are the development of enhanced nickel matrix nanocomposite coatings and the optimization of the codeposition parameters. Two different nanopowder, i.e. silicon carbide and alumina, were added to a Watts type galvanic bath in order to produce the nanocomposites coatings and ultrasonic vibrations have been considered as an alternative to pitting control agents in order to produce pore-free layers. The powders and the stability of their suspensions have been studied by DLS and ζ-potential measurements. After the study of the relationship between process parameters and embedded ceramic particle amount, the optimized deposition condition have been evaluated and used for the production of the sample for the final properties characterization and to test the use of the ultrasounds. Unique, functional properties of composite coatings are derived not only from the presence of the particles dispersed in the bulk of the metallic matrix but also on the matrix microstructural changes induced by the interaction between particles and electrocrystallization. Therefore the microstructure of all type of coatings have been analyze by SEM on the top-view and on the cross-section, the agglomeration of the powder have been observed by LOM in case of Ni/Al2O3 and by TEM in case of Ni/SiC. It has been demonstrated that the codeposition of the SiC particles induces an important microstructural refinement while the Al2O3 powder is strongly agglomerated and only under ultrasonic vibrations can be dispersed and change the field oriented columnar structure into un-oriented fine grains. Ultrasounds revealed to have positive effect not only in avoiding the porosity but also dispersing the ceramic powder and increasing the codeposition rate. This allowed to produce protective and very refined coatings. All these interactions between ultrasounds, nanopowder and electrocrystallization lead to improved mechanical properties and the enhancement is proportional both to powder content and dispersion degree. Moreover a well dispersed powder induce, an improvement also in the corrosion protection leading to the formation of a more stable and resistant passive oxide. Concluding, Ni/Al2O3 nanopowder codeposition leads to hardening effect, but does not affect the corrosion resistance because the particles agglomeration is not completely avoided even if deposited under ultrasonic vibrations. The SiC particles, on the contrary, can be better dispersed thus leading to improved both mechanical and protective properties.

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Thiel, Jacqueline [Verfasser], et Wiebke [Akademischer Betreuer] Hansen. « The impact of microRNAs 96/183 and neuroplin-1 on t cell activation and autoimmunity / Jacqueline Thiel ; Betreuer : Wiebke Hansen ». Duisburg, 2018. http://d-nb.info/1171705085/34.

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F, Mancarella. « MicroRNAs role in type 1 diabetes pathogenesis : a dialogue between pancreatic islets and immune system ». Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1069077.

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Type 1 diabetes (T1D) is a chronic multifactorial autoimmune disease that includes 5-10% of diabetes cases and is characterized by the immune-mediated insulin secreting β cell destruction with consequent loss of β cell mass and hyperglycemia. In autoimmune diabetes, the selective β cell destruction is the result of a series of mechanisms including, but not limiting to autoreactive T cells direct β cell destruction and inflammatory stress, resulting in a dramatic loss of functional β cell mass. MicroRNAs are small non coding 19-24 nucleotides RNAs that negatively regulate gene expression, binding selectively their mRNAs target and leading to their translational repression and/or degradation. It was also remarked that miRNAs are involved in T1D pathogenesis, by regulating a series of processes both in β cells and lymphocytes that ranged from cell metabolic dysfunction and apoptosis to dedifferentiation and immune molecule secretion. Additionally, it has been suggested that secreted microRNAs can take part in the communication between immune system and pancreatic endocrine cells; therefore, studying such dialogue could help to better understand T1D pathogenesis and to the identification of biomarkers that reflect the diseased status of the target organ. In order to investigate the role of miRNAs as biomarkers of T1D pathogenesis both at endocrine and immune interface, the study can be subdivided into the following sections: 1) MiRNAs as circulating biomarkers of diseased-target tissue- In this section, miR-409-3p was found downregulated in murine and human plasma of T1D subjects, highlight the importance to find a lymphocyte deriving circulating biomarker that reflect the target organ pathological status. 2) MiRNAs as modulators of β cell function- miR-183-5p was downregulated in pancreatic endocrine tissue of mouse and human diabetic patients, contributing to β cell protection from apoptosis through the modulation of anti-apoptotic factor Bach2 and through the potential induction of a dedifferentiation phenomenon. This study demonstrated that β cells are able to react to stress and to cell damage through a miRNA-mediated protective phenomenon. 3) Secreted/Immune-derived miRNAs as mediators of β cell apoptosis- Exosomes enriched in miR-142-3p/5p and miR-155 and secreted by T autoreactive lymphocytes, induced selective β cell apoptosis, through the modulation of proinflammatory chemokine expression. The selective AAV “Sponge” inactivation of miR-142-3p/5p, miR-150 and miR-155 induced β cell protection of prediabetic NOD mice from the autoimmune attack that occurs in T1D, inducing the reduction of the proinflammatory chemokine CXCL10 specifically in β cells than in α cells. Such study remarked the exosome-mediated communication dynamics between immune system components and endocrine cells in the center of this dialogue, miRNAs give their fundamental contribution and more importantly, as it has already been reported, it’s possible to actively and therapeutically interfere in this dialogue in order to positively change the β cell fate.

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Spears-Dean, Dorothy. « Predicting the Diffusion of Next Generation 9-1-1 in the Commonwealth of Virginia : An Application Using the Deployment of Wireless E9-1-1 Technologies ». VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/183.

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This study examines the deployment of Wireless E9-1-1 Phase One and Wireless E9-1-1 Phase Two as a diffusion of innovation. The research method used in this study is a cross-sectional study employing secondary data in a discriminant function analysis. The study population is Virginia units of local governments (95 counties and 39 cities) that had not deployed Wireless E9-1-1 Phase One or Wireless E9-1-1 Phase Two as of January 1, 2001. The period of time included in this study is from 2001 to 2006. The purpose of the study is to assess the overall accuracy of the three principle theories of policy innovation adoption: diffusion, internal determinants, and unified theory, which are variations of the fundamental diffusion theory, in predicting the deployment of wireless E9-1-1 by Virginia units of local government. This assessment was conducted by identifying Virginia specific variables from models associated with these policy innovation theories to determine the best performing model for the deployment of Wireless E9-1-1 throughout the Commonwealth of Virginia. The Virginia specific variables utilized in this study are: Wealth, Population, Fiscal Health, Dedicated Funding, Financial Dependency, Urbanization, Regionalism, and Proximity to Interstate. Dedicated Funding and Regionalism had the largest absolute size of correlation among the predictor variables for the deployment of Wireless E9-1-1 Phase One and Wireless E9-1-1 Phase Two, thus generating the best performing model. This information will provide the basis from which to develop a statewide comprehensive policy and plan for Next Generation 9-1-1 and will help provide an answer to the question of when and how governments get involved in designing and implementing a 9-1-1 emergency service network.

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Livres sur le sujet "183/.1"

1

Joe, Shuster, dir. Superman : Sunday classics, strips 1-183, 1939-1943. New York : Sterling Pub. Co., 2006.

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Peter, Gauch, Aepli Viktor, Casanova Hugo et Switzerland Bundesgericht, dir. Schweizerisches Obligationenrecht, allgemeiner Teil (Art. 1-183) : Rechtsprechung des Bundesgerichts. 3^e éd. Zürich : Schulthess, 1992.

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Blaževičius, Jonas. Lietuvos Respublikos bausmių vykdymo kodekso komentaras : I-V dalys (1-183 straipsniai). Vilnius : Teisinės informacijos centras, 2004.

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Hope, Murry. The Gaia dialogues. Bristol : Thoth, 1995.

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Алексакіс, В. [Раніше. Афіни : Ександас, 1994.

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Баколас, Н. [Міфологія. Салоніки : Паратирітис, 1989.

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Grabot, Bernard, Anne Mayère et Isabelle Bazet, dir. ERP Systems and Organisational Change. London : Springer London, 2008. http://dx.doi.org/10.1007/978-1-84800-183-1.

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Pal, Nikhil R., et Lakhmi Jain, dir. Advanced Techniques in Knowledge Discovery and Data Mining. London : Springer London, 2005. http://dx.doi.org/10.1007/1-84628-183-0.

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J, Pendrick Gerard, dir. Antiphon the sophist : The fragments. Cambridge, U.K : Cambridge University Press, 2001.

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Maschinski, Joyce, Kristin E. Haskins et Peter H. Raven, dir. Plant Reintroduction in a Changing Climate. Washington, DC : Island Press/Center for Resource Economics, 2012. http://dx.doi.org/10.5822/978-1-61091-183-2.

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Chapitres de livres sur le sujet "183/.1"

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Caralis, Dennis G. « Lower Extremity Arterial Disease Co-Existing With Coronary Artery Disease ». Dans Lower Extremity Arterial Disease, 183–221. Totowa, NJ : Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-881-1:183.

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Winn, Shelley R. « The Manipulation of Mesenchymal Stem Cells for Bone Repair ». Dans Stem Cells in Endocrinology, 183–206. Totowa, NJ : Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-900-1:183.

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Navaneethan, Udayakumar, et Ralph A. Giannella. « Definition, Epidemiology, Pathophysiology, Clinical Classification, and Differential Diagnosis of Diarrhea ». Dans Diarrhea, 1–31. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_1.

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Brown, Alphonso, et Steven D. Freedman. « Pancreatic Exocrine Insufficiency ». Dans Diarrhea, 177–88. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_10.

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Young, Rosemary J., et Jon A. Vanderhoof. « Bacterial Overgrowth ». Dans Diarrhea, 189–207. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_11.

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Guandalini, Stefano. « Celiac Disease ». Dans Diarrhea, 209–24. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_12.

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Fantry, George T. « Whipple Disease ». Dans Diarrhea, 225–36. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_13.

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Carlisle, Erica M., et Mindy B. Statter. « Surgical Conditions Presenting with Diarrhea ». Dans Diarrhea, 237–63. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_14.

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Dhere, Tanvi, Julia Massaad et Shanthi V. Sitaraman. « Chronic Diarrheal Disorders due to Endocrine Neoplasms ». Dans Diarrhea, 265–79. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_15.

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Terrin, Gianluca, et Roberto Berni Canani. « Diarrhea from Enterotoxins ». Dans Diarrhea, 281–98. Totowa, NJ : Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-183-7_16.

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Actes de conférences sur le sujet "183/.1"

1

Shibata, Tomohiro, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Ryuji Takahashi, Kosuke Watari et al. « Abstract LB-183 : Y-box binding protein-1 YB-1 negatively regulates ERα expression accompanying by enhanced HER2/ErbB2 expression in breast cancer ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-lb-183.

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Brink, Todd, et Glenn Ballard. « SLAM — A Case Study in Applying Lean to Job Shops ». Dans Construction Research Congress 2005. Reston, VA : American Society of Civil Engineers, 2005. http://dx.doi.org/10.1061/40754(183)1.

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Oliveira, H. M. A., H. F. Dutra, F. S. Araújo, M. V. Pacheco et L. A. S. Correia. « Teste de condutividade elétrica em função da pré-hidratação em sementes de pinhão-manso (Jatropha curcas L.) ». Dans VIII Simpósio Brasileiro de Pós-Graduação em Ciências Florestais. Recife, Pernambuco, Brasil : Universidade Federal Rural de Pernambuco, 2014. http://dx.doi.org/10.12702/viii.simposfloresta.2014.94-183-1.

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Shagaev, Viktor, et Lyudmila Alyaeva. « Completion of the political transformation of the Swiss Union : from a confederation to a single federal federal state (Constitution of 1874) ». Dans Development of legal systems of Russia and foreign countries : problems of theory and practice. ru : Publishing Center RIOR, 2023. http://dx.doi.org/10.29039/02110-1-183-188.

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The article deals with the issues of constitutional consolidation of the results of the transformation of the Swiss Union from a confederal association of cantons into a single federal state with significant independence of the subjects. The issues of the formation of authorities, their functions, the features of the legislative process, the delimitation of powers between the union and the cantons are analyzed.

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Аркушина, Г. Ф. « Флористичні особливості та санітарно-гігієнічні проблеми берегів річок в межах міста Кропивницького ». Dans PROSPECTS FOR EARTH EXPLORATION : CURRENT STATE AND RATIONAL USE OF RESOURCES. Baltija Publishing, 2021. http://dx.doi.org/10.30525/978-9934-26-183-1-1.

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Watari, Kosuke, Tomohiro Shibata, Ai Shinoda, Hideyuki Abe, Akihiko Kawahara, Yuichi Murakami, Eiji Oki et al. « Abstract 183 : N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells ». Dans Proceedings : AACR Annual Meeting 2019 ; March 29-April 3, 2019 ; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-183.

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Watari, Kosuke, Tomohiro Shibata, Ai Shinoda, Hideyuki Abe, Akihiko Kawahara, Yuichi Murakami, Eiji Oki et al. « Abstract 183 : N-myc downstream regulated gene 1 (NDRG1) is indispensable for VEGF-A-induced tumor angiogenesis through PLCγ/ERK signaling activation in vascular endothelial cells ». Dans Proceedings : AACR Annual Meeting 2019 ; March 29-April 3, 2019 ; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-183.

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Baiz, Daniele, Dana Yancey, Young A. Choi, Vitaliy Baurin, Yelena Karpova, Sazzad Hassan, Waldemar Debinski et George Kulik. « Abstract 183 : Loss of Bad phosphorylation and Mcl-1 expression is necessary for rapid apoptosisinduced by combination of TGFα-PE and ZSTK474 in prostate cancer cells ». Dans Proceedings : AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011 ; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-183.

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Nedrow, Jessie, Anders Josefsson, Sunju Park, Sagar Ranka et George Sgouros. « Abstract LB-183 : The impact of protein concentration on the distribution of 111In-antibody conjugate for imaging of programmed death-ligand 1 (PD-L1) ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-183.

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Kandrashina, E. A. « IDENTIFICATION OF ENTITIES THAT HAVE THE ABILITY TO MAKE ORGANIZATIONAL CHANGES ». Dans Russian science : actual researches and developments. Samara State University of Economics, 2020. http://dx.doi.org/10.46554/russian.science-2020.03-1-183/186.

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The article is devoted to identifying a range of subjects whose abilities determine the effectiveness of change management processes. Such subjects include both individuals such as managers and employees of the organization, and the organization itself, which acts as an institutional economic entity

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Rapports d'organisations sur le sujet "183/.1"

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SGC, Servicio Geológico Colombiano. Mapa Geomorfológico aplicado a movimientos en masa escala 1:100.000. Plancha 183 Coquí. Producto. Bogotá : Servicio Geológico Colombiano, février 2015. http://dx.doi.org/10.32685/4.7.2015.515.

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SGC, Servicio Geológico Colombiano. Zonificación de la susceptibilidad y la amenaza relativa por movimientos en masa escala 1:100.000. Plancha 183 Coquí. Producto. Bogotá : Servicio Geológico Colombiano, février 2015. http://dx.doi.org/10.32685/4.7.2015.554.

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Toossi, Saied, et Jordan W. (Jordan William) Jones. food and nutrition assistance landscape. Washington, D.C. : Economic Research Service, U.S. Department of Agriculture,, juin 2023. http://dx.doi.org/10.32747/2023.8054020.ers.

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The U.S. Department of Agriculture (USDA) administers 15 domestic food and nutrition assistance programs that affect the lives of millions of people and account for roughly two-thirds of USDA's annual budget. In response to the Coronavirus (COVID-19) pandemic, USDA launched additional temporary programs and implemented numerous policy changes that expanded the scope and coverage of existing programs. Together, these programs contributed to $183 billion in spending on food and nutrition assistance programs in fiscal year (FY) 2022 (October 1, 2021-September 30, 2022). This report uses preliminary data from USDA, Food and Nutrition Service (FNS) to examine program trends and policy changes in USDA's largest U.S. food and nutrition assistance programs through FY 2022. It also summarizes a recent USDA, Economic Research Service (ERS) report examining the prevalence of household food insecurity in the United States in 2021 and another USDA, ERS report examining changes in food choices in the USDA Foods program.

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