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Rusconi, Roberto. « Integrated musical perspectives : how matter becomes art music : portfolio of compositions and technical commentary ». Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/integrated-musical-perspectives(e7f19391-0941-4428-bc06-217f8c998f45).html.
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This thesis accompanies the folio of the acoustic and electroacoustic compositions of the portfolio, which consists of a work for soli, choirs and orchestra, an orchestral piece, a solo for oboe, four ensemble chamber composition and a string quartet with sound projection and live electronics. The works exhibit a variety of cross-disciplinary approaches from theatrical, live electronics, networked performance, and narrative and multichannel/sound projection. The main concerns spanning the portfolio are the connections navigated through a 'synthesis' of multiple disciplines within the language of acoustic and electroacoustic music, and challenging areas of research that question and raise new musical possibilities. In all these works the morphological handling of music matter is always intertwined with issues of formal construction. For each composition I described applied studio techniques, sound sources, transformations and formal elements. As compositional tools, special software have been used, explored and developed in contrasting programming languages. These programs are briefly introduced, showing their links to compositional processes. The commentary presents supplementary information on each work, with a view to providing the reader with insights into the evolution of my compositional vocabulary. A particular attention has been devoted to the pre compositional and perceptual spatial aspects of my work, with reference to theoretical writings and research in the field.
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Patel, Shanon. « The clinical applications of cone beam computed tomography in endodontics ». Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/the-clinical-applications-of-cone-beam-computed-tomography-in-endodontics(28daff53-0941-4b36-b8ea-beeb7dc2a8e6).html.
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A series of 5 investigations assessed the application of cone beam computed tomography (CBCT) for the management of endodontic problems. Cone beam computed tomography improved the detection of the presence and absence of simulated periapical lesions in human dry mandibles. The overall sensitivity was 0.248 and 1.0 for periapical radiography and CBCT respectively. The receiver operating characteristics (ROC) area under the curve (AUC) values were 0.791 and 1.000 for intraoral radiography and CBCT, respectively. There was no improvement in the detection of artificially created vertical root fractures (VRF) in root treated teeth using CBCT compared with periapical radiographs. The overall AUC value of incomplete and complete VRF was 0.53 for periapical radiography and 0.45 for CBCT (p=0.034). The overall sensitivity of periapical radiography (0.05) was lower than CBCT (0.57) regardless of the extent of the VRF (p=0.027). Periapical radiographs (0.98) had a higher overall specificity than CBCT (0.34), (p=0.027). The prevalence of periapical radiolucencies of 273 individual roots in 151 teeth viewed with CBCT (48%) of teeth treatment planned for endodontic treatment was significantly higher when compared with periapical radiographs (20%). Periapical radiographs and CBCT scans of 123 of the teeth in 99 patients assessed 1 year after completion of primary root canal treatment were compared to their respective pre-treatment periapical radiographs and CBCT scans. Analysis by tooth revealed that the ’healed’ rate (absence of periapical radiolucency) was 87% using periapical radiographs and 62.5% using CBCT (p<0.001). This increased to 95.1% and 84.7% respectively when the ’healing’group (reduced size of periapical radioiUcency) was included (p<0.002). Outcome diagnosis of teeth showed a statistically significant difference between systems (p<0.001). The influence of periapical radiography and CBCT for the detection and management of in-vivo root resorption lesions was assessed. Periapical radiography ROC ADC values were 0.780 and 0.830 for diagnostic accuracy of internal and external cervical resorption respectively. The CBCT ROC AUC values were 1.000 for both internal and external cervical resorption. There was a significantly higher prevalence (p=0.028) for the correct treatment option being chosen with CBCT compared with intraoral radiographs. These investigations demonstrated that CBCT is more effective in diagnosis ex vivo and in vivo periapical radiolucencies, and for the diagnosis and management of root resorption. However, CBCT did not improve the detection of VRF in this experimental model.
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Geng, Xinyan. « Investigations into how best to target FGFR2 mutant endometrial cancer ». Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/123437/1/Xinyan%20Geng%20Thesis.pdf.
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Endometrial cancer (EC) is the fourth most common cancer in women in developed countries, such as North America, Europe and Australia. Patients with low-grade, early-stage disease usually have a favourable survival rate. However, patients that present at an advanced stage of disease have an average survival of only 12 months. Current treatments for these patients are radiation and chemotherapy, which offer limited clinical benefit. There is no efficient treatment for advanced EC. Improved therapeutic approaches are needed for the treatment of recurrent and metastatic endometrial cancer. Recent advances in cancer biology have resulted in the development of molecular targeted therapies.
The Fibroblast Growth Factors Receptor (FGFR) family and their ligands (fibroblast growth factors, FGFs) regulate a broad spectrum of physiological processes as well as tissue patterning and organogenesis during embryogenesis. Abnormally activated FGFRs have been identified in various cancers and are emerging as potential therapeutic targets. The Pollock laboratory and other groups have demonstrated that 10-20% of endometrioid ECs carry FGFR2 mutations that may be a novel therapeutic target in endometrial carcinoma.
Preclinical studies show that inhibition of FGFR can inhibit EC cell growth in vitro. However, FGFR inhibitors are not as efficient at inhibiting tumour growth in vivo. We aim to find a way to improve the efficacy of FGFR inhibition in cancer treatment. About 90% of EC patients harbour genetic aberrations in the components of the PI3K/AKT pathway which indicates this signalling pathway plays an important role in the development of EC. Work from our lab demonstrates that inhibition of FGFR results in abrogation of MAPK activation in sensitive EC cells, however, the PI3K/AKT signalling pathway remains unaffected. PI3K/AKT signalling plays a vital role in cancer cell proliferation and survival, furthermore crosstalk between the MAPK and PI3K/AKT signalling pathways is associated with resistance to targeted therapies. Thus, the first aim of this study was to examine whether combination of the FGFR inhibitor (BGJ398) with various different PI3K inhibitors was synergistic in FGFRi sensitive EC cells.
We present data that the combination of the pan-FGFR inhibitor (BGJ398) with pan-PI3K inhibitors (GDC-0941, BKM120) or a p110α-selective PI3K inhibitor (BYL719) was synergistic in inhibiting cell growth. Significantly more cell death and inhibition of long-term cell survival was observed in the combination treatments compared to each of the single drug treatments. Importantly, these effects could also be observed at lower concentrations. This study is the first to indicate that partial inhibition of the PI3K signalling pathway could significantly increase cell death when combined with the FGFR inhibitor BGJ398 in FGFR2 mutant EC cells. These data provide evidence that sub-therapeutic doses of PI3K inhibitors could enhance the efficacy of anti-FGFR therapies and a combination therapy may represent a superior therapeutic treatment in FGFR2 mutant EC patients. The in vivo work (conducted by Dr Vanessa Bonazzi) shows that the combination of BGJ398 and GDC-0941 and BYL719 resulted in tumour regression, while single drug treatment only slowed tumour growth. Interestingly, BYL719 alone resulted in increased tumour growth in tumour xenografts of AN3CA but not JHUEM2.
In the first results chapter we further investigated the mechanism of enhanced cell death from the combination of BGJ398 and PI3K inhibitors. The activation of ERK and AKT has been inhibited by the combination of BGJ398 and PI3K inhibitors. However, the combination of the MEK inhibitor trametinib and the PI3K inhibitors induced less cell death than inhibition of the FGFR and PI3K signalling pathways. BGJ398 but not trametinib or GDC-0941 inhibited the activity of PLCγ1. We have also found trametinib up-regulated PLCγ1 activity, which is a novel finding in the field. We next employed several pharmacological inhibitors to investigate whether PLCγ1 is involved in the cell death observed following the combination of BGJ398 and GDC-0941 treatment. As there is no PLCγ1 inhibitor available currently, we used two different pan-PLC inhibitors, manoalide and U73122. Co-inhibition of the MAPK, PI3K/AKT and PLC signalling recapitulated cell growth inhibition seen with the combination of FGFR and PI3K inhibitor in both cell lines. Cell death induced by the combination of PLC inhibitors with trametinib and GDC0941 was similar as the combination BGJ398 and GDC0941 in AN3CA, but significantly less than the combination BGJ398 and GDC0941 in JHUEM2. Unfortunately, Western blotting was unable to show inhibition of PLCγ1 bringing into question whether these PLC inhibitors inhibited PLC function sufficiently, and whether the phenotypic effects of manoalide and U73122 when added to the trametinib and GDC0941 combination are due to inhibition of PLCγ1.
The second results chapter reports efforts to identify the mechanism of intrinsic resistance to FGFR inhibition in EC cell lines carrying FGFR2 activating mutations but showing intrinsic resistance to FGFR inhibition (EI, EN1078D, and MFE319) with comparisons to the two sensitive EC cell lines (JHUEM2 and AN3CA). We have observed sustained activation of ERK in the resistant cells after treatment with an FGFR inhibitor, while ERK was inhibited in the sensitive cells. Inhibition of the MAPK signalling pathway could not sensitise the resistant cells to FGFR inhibition. Although several other receptor tyrosine kinases (RTKs) were hyperactivated in these cells, pharmacological inhibition did not show they were reliant on these RTKs. Co-inhibition of these kinases did not sensitise these cells to BGJ398. Knockdown of FGFR2 by shRNA in the sensitive cells induced moderate cell death, but limited cell death in the resistant cells. Interestingly, co-inhibition of the MAPK, PI3K/AKT and PLC signalling pathways has induced markedly less cell growth inhibition in the resistant cells compared to the sensitive cells, suggesting the resistant cells are less dependent on these central signalling pathways than the sensitive cells. Western blotting results showed that FGFR2 expression was considerably lower in the resistant cells than in the sensitive cells. Based on these results we have concluded that FGFR2 mutation status is not the only factor that determines sensitivity to FGFR inhibition, high expression of mutant FGFR2 is also important. This is a novel finding in the field and one which could guide patient select criteria in future clinical trials. Lastly, we show that FGFR2 knockdown in medium containing 10% FBS has little impact on downstream ERK phosphorylation whereas pan FGFR inhibition with BGJ398 could totally abrogate ERK phosphorylation. In cells grown overnight in serum starved conditions, FGFR2 knockdown did reduce downstream ERK phosphorylation but not to the same extent as pan FGFR inhibition in full growth medium. These data suggest that inhibition of FGFR2 alone is insufficient and that inhibition of multiple FGFRs will be more effective as a cancer treatment.
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Sava, Olga. « Dualismus der Einkunftsarten Ansätze zur Steuerreformdiskussion aus betriebswirtschaftlicher Sicht / ». Wiesbaden : Deutscher Universitäts-Verlag, 2007. http://sfx.metabib.ch:9003/sfx_locater?sid=ALEPH:DSV01&genre=book&isbn=978-3-8350-0941-7&id=doi:10.1007/978-3-8350-5489-9.
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Lakshmanan, Aparna. « Modulation of Sodium Iodide Symporter-mediated Thyroidal Radioiodide Uptake by Small Molecule Inhibitors, Natural Plant-based Products and microRNAs ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429407914.
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Diab, Duranton Salam. « Phonétique et sémantique dans le lexique de l'arabe : le "'Ibdal" dans la tradition grammaticale arabe, l'étude de la matrice {[coronal], [dorsal]} ». Lyon, Ecole normale supérieure, 2009. http://www.theses.fr/2009ENSF0061.
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The thesis comprises two main parts : one historical and the other theoretical. The first part is a study of the ’ibdāl in which several salient works are analysed. Four Arab scholars whose works are the most important in the area under consideration are studied : Ibn al-Sikkīt, Al-Zajjājī, Abū al-Ṭayyib al-Luġawī and Ibn Jinnī. We examine the way in which, within the framework of the Arabic grammatical tradition, the lexicographers and grammarians have apprehended the phonetic and semantic similarities present in the Arabic lexicon and which are referred to by the name : ’ibdāl. The second part is a contribution to the theory of matrices and etymons (TME) elaborated by G. Bohas. We apply TME to the study of the {[coronal], [dorsal]} matrix which has a substantial lexical corpus. We endeavour to demonstrate that meaning is organized around a matrix of features (a macro-significant) associated with a macro-signifié. We also examine the polysemic, homonymic or enantiosemic relationships which are present within the same lexical heading, establishing the typology of these semantic combinations arising from the crossing of etymonsLa thèse s’articule en deux grandes parties : une historique et l’autre théorique. La première propose une étude du ’ibdāl par l’analyse de quelques ouvrages repères. Quatre savants arabes y sont étudiés : Ibn al-Sikkīt, Al-Zajjājī, Abū al-Ṭayyib al-Luġawī et Ibn Jinnī dont les œuvres sont les plus importantes dans le domaine concerné. Nous y examinons la manière dont les lexicographes et grammairiens ont, dans le cadre de la tradition grammaticale arabe, appréhendé les similitudes phonétiques et sémantiques présentes dans le lexique de l’arabe et désignées sous le nom de : ’ibdāl. La seconde partie se veut une contribution à la théorie des matrices et étymons (TME) élaborée par Bohas. Notre contribution consiste dans l’étude de la matrice {[coronal], [dorsal]} qui présente un corpus lexical conséquent. Nous nous attachons à montrer que le sens s’articule en une matrice de traits (macro-signifiant) associée à un macro-signifié. Nous étudions également les relations de polysémie, d’homonymie ou d’énantiosémie présentes au sein d’une même entrée lexicale, en établissant la typologie de ces combinaisons sémantiques issues du croisement des étymons
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Bell, Samuel D. « The impact of the Type 094 ballistic missile submarine on China's nuclear policy ». Thesis, Monterey, Calif. : Naval Postgraduate School, 2009. http://edocs.nps.edu/npspubs/scholarly/theses/2009/Jun/09Jun%5FBell.pdf.
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Thesis (M.A. in Security Studies (Far East, Southeast Asia, and the Pacific))--Naval Postgraduate School, June 2009.Thesis Advisor(s): Twomey, Christopher. "June 2009." Description based on title screen as viewed on July 13, 2009. Author(s) subject terms: Type 094, Chinese Nuclear Policy, No First Use, Jin, Ballistic Missile Submarine Includes bibliographical references (p. 99-108). Also available in print.
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Stubbs, Estelle Vivien. « A study of the codicology of four early manuscripts of the Canterbury Tales ». Thesis, University of Sheffield, 2006. http://etheses.whiterose.ac.uk/15177/.
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This thesis is a study of the physical features of the four earliest manuscripts of the Canterbury Tales all dated to the first years after the death of Geoffrey Chaucer. I assess the ways in which codicological examination can contribute to the understanding of a complex textual tradition and inform the study of the text. The thesis is divided into two volumes. The first volume contains the seven chapters which make up the thesis. The first chapter contains a review of the printed editions of the poem since Caxton's first edition of 1476 and a summary of the most important contributions of scholarship in the twentieth century. It reveals that many influential editions and much scholarship on the textual tradition of the poem have been achieved with scant consultation of the extant manuscripts. The second chapter addresses the problems which have arisen as a result of this neglect and offers suggestions for a different approach to manuscript analysis which will be provided as a result of the examination of the manuscripts in the remainder of the thesis. Chapters three to six contain detailed analyses of the four manuscripts in the survey: Aberystwyth, National Library of Wales MS. Peniarth 392D (Hengwrt), Oxford, Corpus Christi College, MS. 198 (Corpus), London, British Library MS. Harley 7334 (Harley 4), and California, San Marino, Huntington Library MS. El. 26 C 9 (Ellesmere). In chapter seven, I summarise the findings and offer suggestions for future research. The second volume contains all the appendices numbered 1-20 followed by 22 Plates. For each manuscript there are four or five separate appendices which provide details of the following: a visual overview, a detailed analysis of individual quires, a list of all rubrics, lines added, omitted or variant in each manuscript, and a list of catchwords.
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Himsworth, Katherine. « The Peniarth MS 22 Brut y Brenhinedd and continuation chronicle, and its 15th century Aberystwyth scribe, Dafydd ap Maredudd Glais ». Thesis, Aberystwyth University, 2015. http://hdl.handle.net/2160/5dcc8e8b-3f1d-4a4d-9713-d9ed9c7288f1.
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The Peniarth 22 manuscript is, except for the last four pages, a fifteenth-century copy of Brut y Brenhinedd, the Welsh translation of Geoffrey of Monmouth's Historia Regum Britanniae; it was penned in 1444 by one Dafydd ap Maredudd Glais. It belongs to the Dingestow family of manuscripts, which in turn is related, in part, to the Llanstephan Version and Liber Coronacionis Britanorum manuscripts, although the detail of this relationship - and that of the Dingestow manuscripts to one another - still begs a number of questions. Peniarth 22 itself is very similar to, though not a copy of, the early fourteenth-century NLW 3036B manuscript. But there are differences in the orthography, and to a lesser extent in the grammatical constructions used by Dafydd which shed light on the changes that were being gradually adopted in the fifteenth century. This is particularly true of the last four pages, which contain Dafydd's own translation of a Latin chronicle, which comprises a continuation of the Brut. While incomplete, largely formulaic and in parts illegible, it includes detail of historical as well as linguistic interest. Dafydd himself, far from being an institutional scribe, led a colourful life including both murder and public service in fifteenth-century Aberystwyth. But he was not, as previously thought, a cleric.
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Wang, Jianlan. « Silk facing of ancient Chinese manuscripts ». Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675481.
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The thesis has profiled silk facing treatments to manuscripts in the Stein Collection in the British Library, via its unique historical background, compared with the lamination technique that was prevalent in conservation in the last century in libraries and archives. The correction of the previous inappropriate preservation methods might have not aroused enough attentiveness, or critical attention, in the conservation arena. IR and Raman spectroscopy were widely applied in this project, for the characterisation of the different silks removed from the manuscripts, in comparison with new silk from commercial suppliers, revealing the ageing of silk, its fragility and stiffness, which causes mechanical abrasion toward the scrolls of ancient manuscripts. Silk's absorption of moisture, and exposure to light, exacerbate this problem. The characterisation of a series of vegetable and animal derived glues emphasises the poor record-keeping of the conservation studios. The non-native and pipeline-processed starches show almost the same pattern in both IR and Raman spectroscopy. Animal glues also show different patterns from the starch-based glues in both IR and Raman spectroscopy. The problems of applying gelatine-base glue in the conservation process are also discussed. The dye-transfer phenomenon has been confirmed: the yellow dye from the manuscripts (which were dyed by water-soluble huangbo extracts) transfer to the glue paste and then to the silk materials, thus causing the discolouration of the manuscripts. Finally, solid-state NMR characterisation with magic angle spinning was used to characterise the silks and glue pastes. The SEM and EDAX study provided the evidence for the existence of fungi and/or bacteria on the glues al1ached to the manuscripts, data being provided from a strong collaboration with Dr. Cristina Silva Pereira from the Universidade Nova de Lisboa, Portugal. Preliminary studies have confirmed that the silk and glue carry Aspergillus niger, Neurospora crass a and Penicillium chrysogenum. This observation provides unimpeachable evidence that long-term damage will occur to the faced manuscripts if the facing is not removed. Currently, the desire for digitisation of manuscripts in the Stein collection in the British Library also enhances the case for the removal of the silk facing materials. The sill<, glue, water and dye, compose a complicated matrix which influence the lifetime and stability of the manuscripts by interaction with the external environment, thus it is believed that the removal the silk facing materials is reasonable, and should be performed if economically viable
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Beattie, Luke Timothy. « How were the anonymous Castle Ashby play manuscripts created, and why ? » Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3478.
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In 1977, a long-lost collection of manuscripts of plays, poems, and non-fiction texts from the 17th century was re-discovered in the library of Castle Ashby, Northamptonshire. Most of the items are not signed by an author, and have no known record of publication or performance. These technically anonymous items have received minimal scholarly attention in the three-plus decades since their recovery, and what comment there has been has not entirely agreed upon the collection's authorship, purpose, or even era of composition. This thesis takes a confident position on those debates by investigating the unsigned manuscripts and their contents through a variety of techniques. This study reviews the collection's known history, past commentators' findings and conclusions, and the physical and textual properties, and comes to an authorial conclusion based on a fresh palaeographic investigation; it then offers a biography of the proposed writer. It statistically analyses the collection's material, palaeographic, and metrical traits, in search of trends that might show a development over time. It applies modern electronic resources to investigate the collection's textual interrelationships and plausible literary sources, and uses contemporary history and the proposed author's biography to suggest conjectural allusions in the writing. Together, those avenues of analysis allow for a best-guess ordering and dating to be proposed for the collection's contents. Turning specifically to the dramatic texts, the thesis then considers the proposed author's potential theatrical resources, searches the manuscripts for evidence of possible professional theatrical use, and gathers dramaturgical information from the texts themselves to form an opinion about how plausible contemporary performances would have been; this is supplemented with the findings from the first modern stagings of all of the dramatic texts, which establish what minimum physical needs the plays would demand in performance, and identify where there are dramaturgical issues that could limit the plays' theatrical practicality. The study's findings up to that point then allow for the collection to be positioned within their period's larger context of authorial and theatrical activity, conclude whether the writer achieved anything unique, and, identifying the collection's major recurring thematic elements, propose a rationale for the writer's authorial activity. In summary, this thesis sets out to determine the conditions that brought the unsigned Castle Ashby texts into existence, and to suggest why they were written at all.
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White, Thomas. « Potential lives : the matter of late medieval manuscripts ». Thesis, Birkbeck (University of London), 2016. http://bbktheses.da.ulcc.ac.uk/222/.
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Late medieval vernacular literary texts frequently reflect on their physical existence; they establish a poetics of material composition that is productively ambivalent about the contingencies of literary making in a manuscript culture. This thesis traces the ‘potential life’ of a late medieval manuscript. Four keywords (blankness, palimpsests, textiles, and fragments) provide the impetus for a discussion that connects a wide range of literary, codicological, and theoretical materials, in a mode that is iterative and additive. Manuscripts are not simply containers or substrates for literary texts; varied and ambivalent ideas about manuscripts are deeply embedded in the medieval period’s cultural and philosophical moment: they are the ‘matter’ of medieval writing in the dual sense of that word. In exploring the theoretical, figurative, and interpretative possibilities of manuscript study this thesis turns to a wide range of late medieval texts: these include the works of Geoffrey Chaucer, vernacular romance, The Book of Margery Kempe, The Book of Sir John Mandeville, and Thomas Hoccleve’s Series. The numerous and varied manuscripts of The Book of Sir John Mandeville form a central focus. As well as engaging with the late medieval period’s own rich vocabulary for describing the transformations of matter, I use contemporary ecological theory and new materialism in order to think further about the materials of medieval books. The work of Michel Serres, Bruno Latour, Tim Ingold, and Jonathan Gil Harris provides the occasion not simply to ‘apply’ contemporary theory to medieval materials, but to trace a more dialectical history in which theoretical, literary, and manuscript materials are brought into productive contact. This thesis demonstrates that late medieval manuscripts are sites where multiple temporalities are interwoven, in a manner that should encourage a critical self-‐‑reflexiveness about how scholars narrate the lives of manuscripts, as well as about the modern archiving procedures that have come to condition our access to the medieval past. It reflects critically on the ways in which the medieval textual record has come to be fragmented, archived, and disciplined in the postmedieval period.
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Buggins, Rosemary Elisabeth. « The Coventry pontifical and liturgical transmission patters in the twelth and thirteenth centuries ». Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.682347.
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The focal point of this thesis is my complete transcription of the thirteenth-century Coventry Pontifical manuscript (Cambridge, University Library, Ff. VI. 9). In order to contextualise the Coventry Pontifical manuscript, this thesis comprises two investigative strands. The first is an exploration of the significance of the manuscript in the lives of its medieval users; the interactions between the manuscript and its culture; and the interplay between the manuscript and its users. To further our understanding of the significance of the Coventry Pontifical to its users, this thesis surveys the liturgical practices included in the manuscript, and how these practices and the production of the manuscript required the skills and money of the general population as well as the monastic community. An examination of routines of the time and an overview of the politics and people connected to the Diocese of Coventry and Lichfield follows. Contemplating the people who used the manuscript and how they used it leads to appreciation of the manuscript, and my transcription of it, beyond the significance to the user. It increases awareness of how and why the manuscript was compiled. The second strand uses the Coventry manuscript as a focus for a broader exploration of textual and musical liturgical transmission patterns of insular pontifical manuscripts in the twelfth and thirteenth centuries. Tracing these patterns of transmission, using a combination of variant categorisation and statistical analysis, reveals any relationships which exist between manuscripts produced across medieval Britain. The analysis, combined with consideration of the nature of pontifical exemplars, allows me to explore how pontifical transmission differs from that of other types of liturgical manuscript. This investigation of transmission patterns pinpoints the relative position of the Coventry manuscript in its insular liturgical setting, and thus emphasises the significance of my complete transcription of the manuscript to current scholarship.
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Fall, Cheikh. « Méthodologie d'Ibn Ğinnî (392/1002) dans l'explication des phénomènes morpho-phonologiques ». Thesis, Paris 3, 2010. http://www.theses.fr/2010PA030053.
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Cette thèse qui se veut une contribution à l’étude des textes des grammairiens arabes portera sur l’orientation explicative qui caractérisait les grammairiens du 4ème/ 10ème siècle. Étant donné que notre intervention se limitera à la morpho-phonologie, nous avons choisi comme auteur Ibn Ğinnî ; considéré comme le grammairien le plus versé dans cette discipline. Nous tenterons d’explorer les principes qui régissent selon Ibn Ğinnî la morpho-phonologie. Une étude détaillée sera consacrée à la notion de lourdeur comme principe fondamental chez Ibn Ğinnî qui explique, d’une forme ou d’une autre, tout phénomène morpho-phonologique. Un recours à d’autres disciplines voisines où la méthodologie adoptée est plus explicite permettra de décoder le langage d’Ibn Ğinnî dans al-H et d’exploiter les implicites de son texte. Ce travail sur l’histoire de la langue mettra en exergue l’aspect interdisciplinaire comme perspective de recherche sur la grammaire arabeThis thesis whose aim is to contribute to the study of the texts of the Arabic grammarian will deal with the explanatory orientation which characterised the grammarians of the 4th/10th century. Given that our intervention focuses on morph phonology, we chose as author Ibn Ğinnî, who is considered to be the most well-learned grammarian in this field. We will try to explore the principles, which according to him, governs morph phonology. A more detailed chapter will deal with the notion of heaviness which is a fundamental principle in Ibn Ğinnî and which explains somehow or other any phonological phenomenon. A study of other related subjects where the methodology adopted is more explicit will enable to understand the language of Ibn Ğinnî in Hasâ’is, and to make use of the implicits of314his texts. This work on the language history will highlight the interdisciplinary aspects as a research perspective in the Arabic grammar
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Rice, Linda J. « The biblical view of reactive attachment disorder ». Santa Clarita, CA : The Master's College, 2006. http://dx.doi.org/10.2986/tren.091-0077.
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Coyle, Rachel Lynn. « Women and pornography, an examination of the problem and how to help them find freedom ». Theological Research Exchange Network (TREN) Access this title online, 2006. http://dx.doi.org/10.2986/tren.091-0041.
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Rogers, Andrew D. « Calling sons to a life worth living a father and son study through Ecclesiastes ». Theological Research Exchange Network (TREN), access this title online, 2006. http://dx.doi.org/10.2986/tren.091-0050.
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Bertelsen, Michelle. « A biblical perspective on euthanasia ». Theological Research Exchange Network (TREN), access this title online, 2006. http://dx.doi.org/10.2986/tren.091-0053.
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Curran, Peggy E. « A biblical perspective on anorexia nervosa, workbook for teens and young adults ». Theological Research Exchange Network (TREN), access this title online, 2006. http://dx.doi.org/10.2986/tren.091-0054.
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Overley, Amy. « Overcoming abuse ». Santa Clarita, CA : The Master's College, 2004. http://dx.doi.org/10.2986/tren.091-0031.
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Pollinger, Millicent M. « A woman's call to loving others through social graces ». Santa Clarita, CA : The Master's College, 2006. http://dx.doi.org/10.2986/tren.091-0059.
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Mario, Erica Guilhen. « Ação do agonista não-peptídico da angiotensina-(1-7), AVE 0991, nas alterações metabólicas induzidas por suplementação com frutose ». Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-96EHGK.
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Recent studies have shown that activation of angiotensin-(1-7) / receptor Mas axis plays important role in intermediary metabolism, evidenced by increase in insulin sensitivity. The compound AVE 0991 is a non-peptide angiotensin-1-7 agonist, which effects in intermediary
metabolism has not yet been studied. Thus, the objective of this study was to evaluate the action of this agonist on the metabolic changes induced by fructose supplementation. Male Sprague-Dawley rats at 5 weeks of age were utilized. The animals were divided randomically into four groups: Group C: animals fed a commercial diet (control) plus vehicle; Group CA: animals fed a commercial diet treated plus AVE 0991 (gavage at 1mg/kg concentration), Group F: animals fed a commercial diet supplemented with 10% fructose in the drinking water treated plus vehicle; Group FA: animals fed a commer cial diet supplemented with 10% fructose in the drinking water treated plus AVE 0991 (gavage at
1mg/kg concentration). Fructose supplementation promoted glucose intolerance and treatment with AVE 0991 reversed this parameter, besides increasing the hepatic glycogen content and reduces serum levels of insulin, triacylglycerols and non-esterified fatty acids. In addition, in the fructose group, total lipids and triacylglycerols secretion by liver were increased and AVE0991 treatment decreased these parameters . In muscle and adipose tissue, the treatment increased the activity of lipoprotein lipase (LPL), and the expression of genes involved in lipid oxidation such as PPAR and CPT-1 were increased. In adipose
tissue, the PPAR gene expression, involved in fat deposition and improvement of insulin sensitivity showed no increase in adipose tissue mass. These results suggest that activation of Mas receptor by AVE 0991 agonist seems to be involved in the improvement of deleterious changes promoted by fructose supplementation.Estudos recentes demonstram que a ativação do eixo angiotensina-(1-7)/receptor Mas, exerce papel importante no metabolismo intermediário, evidenciado pelo aumento da sensibilidade à insulina. O composto AVE 0991 é um agonista não -peptídico da angiotensina-1-7, cujos efeitos sobre o metabolismo intermediário ainda não foram estudados. Desta forma, o objetivo do presente trabalho foi avaliar a ação deste agonista sobre as alterações metabólicas induzidas pela suplementação com frutose. Para isso foram utilizados ratos machos Sprague-Dawley com 5 semanas de idade. Os animais foram divididos em grupo controle (C) que recebeu dieta comercial e grupo frutose (F) que foi alimentado com dieta comercial e suplementados com 10% de frutose na água de beber. Após 3 semanas de suplementação com frutose os animais foram subdivididos e tratados durante 2 semanas por gavagem com veículo (grupos C e F) ou tratados com AVE 0991 na concentração de 1mg/Kg de PC (grupos CA e FA). A suplementação com frutose promoveu uma intolerância à glicose e o tratamento com AVE 0991 reverteu esse parâmetro, além de aumentar o conteúdo hepático de glicogênio e reduzir os níveis séricos de insulina, triacilgliceróis e de ácidos graxos não -esterificados. Além disso, o grupo que recebeu apenas frutose apresentou um teor aumentado de lipídios totais no fígado, o qual foi acompanhado por aumento da secreção hepática de triacilgliceróis enquanto o tratamento com AVE 0991nos animais suplementados com frutose reduziu tanto o conteúdo de lipídi os totais quanto a secreção hepática de triacilgliceróis. No músculo e no tecido adiposo o tratamento com o agonista do receptor Mas aumentou a atividade da lipase lipoproteíca (LPL), sendo que no músculo houve um aumento da expressão de genes envolvidos na oxidação lipídica, como PPAR e CPT-1, enquanto que no tecido adiposo houve um aumento da expressão gênica PPAR, envolvido na deposição de lipídica e na melhora da sensibilidade a insulina, entretanto não houve aumento da massa do tecido adiposo. Esses resultados sugerem que a ativa ção do receptor Mas pelo agonista AVE 0991 parece estar envolvida na melhora das alterações deletérias promovida pela suplementação com frutose.
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Sanderson, Robert. « Linking past and future : an application of dynamic HTML for medieval manuscript editions ». Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288863.
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Hwang, Joo Yeon. « Analysis and rehearsal consideration on Antonio Vivaldi's Gloria : RV 589 ». Kansas State University, 2012. http://hdl.handle.net/2097/13802.
Texte intégralRésumé :
Master of MusicDepartment of Music
Julie Yu-Oppenheim
This report presents the biography of the composer Antonio Vivaldi, background of his composition Gloria, musical characteristics and analysis. Moreover, for a successful performance, rehearsal plans and techniques are also included. Antonio Vivaldi (1678-1741), one of the representative composers in Baroque period (1600-1750), wrote Gloria, in the early 18th century. The composition date is still disputed between scholars. He composed three settings of the Gloria text: RV 588, 589 and 590. Out of them RV 589 is the most performed setting. Gloria consists of twelve movements and orchestration of trumpet, oboe, strings, and continuo. Homophonic and polyphonic style is prevalent in this work. In addition, focus should be placed on the harmonic suspensions, the flow of chromatic melodic lines and melismas. For the recital, Chamber Singers consisted of 23 people who were the members of Concert Choir who have training focusing on clean and light tone with non-vibrato style.
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Roth, Robert Ray. « A survey of form and compositional practices of Ralph Vaughan Williams, Igor Stravinsky, Paul Hindemith, and Robert Roth in Kyrie of the mass ordinary ». Kansas State University, 2014. http://hdl.handle.net/2097/17599.
Texte intégralRésumé :
Master of MusicDepartment of Music, Theater, and Dance
Craig Weston
Ralph Vaughan Williams, Igor Stravinsky, and Paul Hindemith, three prolific composers of the 20th century, wrote for the medium of the mass ordinary in different ways. This report comprises a survey of those composers’ styles using the Kyrie movement of the mass ordinary as the main vehicle of compositional exploration. The results of this compositional survey examine the form and various techniques the composers employ to garner the same emotional response from the listeners of the Kyrie text. The final portion of the report explores the author’s personal compositional contribution to the mass ordinary.
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Benaissa, Amin. « Thirty new literary and documentary papyri from Oxyrhynchus ». Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491579.
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Brzezinski, Laura [Verfasser]. « Vergleich des Proteasom-Inhibitors Bortezomib und des Immunoproteasom-Inhibitors ONX-0914 in ihrer Wirkung auf kortikale Primärkulturen der Ratte / Laura Brzezinski ». Magdeburg : Universitätsbibliothek, 2018. http://d-nb.info/1177881470/34.
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Yang, Hong. « Grain production in China : productivity changes and provincial disparities, 1978-1990 ». Title page, contents and abstract only, 1994. http://web4.library.adelaide.edu.au/theses/09PH/09phy218.pdf.
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Goetzke, Carl Christoph [Verfasser]. « Die Bedeutung des Low Molecular Weight Protein 7 (LMP7)- spezifischen Inhibitors ONX 0914 bei der viralen Infektion der Maus / Carl Christoph Goetzke ». Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2018. http://d-nb.info/1170876463/34.
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Leite, Karla Carneiro de Siqueira. « Caracterização eletroquímica do composto LQFM-091, obtido por hibridação molecular a partir dos protótipos nimesulida e BF-389 ». Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5380.
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Nimesulide is an anti-inflammatory drug (NSAID) whose preferential selectivity for cyclooxygenase-2 (COX-2) leads to fewer adverse effects and wide use. Nimesulide, like other NSAIDs and selective COX-2 by inhibiting a single metabolic pathway of the arachidonic acid cascade are still responsible for gastrointestinal and cardiovascular side effects. However, recent studies show that the development of multi-targeted anti-inflammatory is an important strategy for obtaining the most effective drugs with fewer side effects. Therefore, the molecular changes from nimesulide has been proposed as a molecular hybridization with a derivative of butylhydroxytoluene BF-389. Such molecular modification products aim to inhibit metabolic pathways of two cascade of arachidonic acid, COX-2 and via the 5-lipoxygenase (LOX). Within the search string and development of new candidate drugs presenting prototypes of electroactive subunits, the characterization of the redox profiles can be made through the electrochemical techniques, which are characterized by speed, low cost and simplicity. In the electrochemical characterization of a new candidate prototype was observed two peaks with anode potential of 1.0V 0,42V and due to oxidation of aromatic amine and phenolic hydroxyl respectively. After analysis by varying the pH and scanning speed, it follows that mass transfer occurs via diffusion processes and proton transfer. The electrochemical analyzes, and are a supplementary means of characterization, were conclusive to prove that the electroactive groups are important in drug mechanism of action, remain free and yet, via a calibration curve constructed by measuring the current (i) due to the potential different concentrations of analyte, one can demonstrate the ability to dispense the new drug candidate developed.
A nimesulida é um fármaco anti-inflamatório não esteroidal (AINE) cuja seletividade preferencial à cicloxigenase-2 (COX- 2) leva à redução de efeitos adversos e amplo uso. A nimesulida, assim como outros AINES e os inibidores seletivos de COX-2 ao inibirem uma única via da cascata metabólica do ácido araquidônico ainda são responsáveis por efeitos colaterais gastrintestinais e cardiovasculares. Entretanto, estudos recentes mostram que o desenvolvimento de anti-inflamatórios multi-alvos representa uma importante estratégia para a obtenção de fármacos mais eficazes e com menos efeitos colaterais. Por isso, modificações moleculares a partir da nimesulida tem sido propostas como a hibridação molecular com um derivado do butilhidroxitolueno o BF-389. Tais produtos de modificação molecular têm a finalidade de inibir duas vias da cascata metabólica do ácido araquidônico, a COX-2 e a via da 5-lipo-oxigenase (LOX). Dentro da cadeia de pesquisa e desenvolvimento de novos candidatos a protótipos de fármacos que apresentem subunidades eletroativas, a caracterização dos seus perfis redox pode ser feita através das técnicas eletroquímicas, que se destacam pela rapidez, baixo custo e simplicidade. Na caracterização eletroquímica de um novo candidato a protótipo foi observado dois picos com potenciais anódicos de 0,42V e 1,0V devido à oxidação da amina aromática e da hidroxila fenólica, respectivamente. Após as análises variando o pH e a velocidade de varredura, conclui-se que a transferência de massa ocorre através de processos difusionais e com transferência de prótons. As análises eletroquímicas, além de serem um meio complementar de caracterização, foram conclusivas para se comprovar que os grupos eletroativos, importantes no mecanismo de ação de fármacos, permanecem livres e ainda, através da curva de calibração construída com a medida da corrente (i) em função do potencial em diferentes concentrações do analito, pode-se demostrar a possibilidade de se dosificar o novo candidato a fármaco desenvolvido.
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Osborn, Sally Ann. « The role of domestic knowledge in an era of professionalisation : eighteenth-century manuscript medical recipe collections ». Thesis, University of Roehampton, 2016. https://pure.roehampton.ac.uk/portal/en/studentthesis/the-role-of-domestic-knowledge-in-an-era-of-professionalisation(b18bb3c6-a961-4643-a74d-5663b316101d).html.
Texte intégralRésumé :
Manuscript recipe books come in all shapes and sizes and run from tens to hundreds of pages. Those from the eighteenth century are not exclusively culinary, also incorporating medical, veterinary and household recipes. Surviving examples are almost all from genteel or elite households, the people who had time and resources to create them, and are preserved in local archives or dedicated collections. This thesis examines the medical recipes in particular and considers their role at a time when alternatives to domestic healthcare were proliferating: increasing numbers of physicians and surgeons, a growth in apothecaries’ shops, commercial offerings such as proprietary medicines and a variety of irregular practitioners. Advice and remedies in print were also widely available in books, periodicals and newspapers. This is the largest study of eighteenth-century manuscript medical recipes yet undertaken, encompassing 241 collections and a total of 19,134 recipes. It begins by considering the collections themselves as material objects, rather than merely text, which no other major study in this area has done. The range of recipes and ailments are assessed against prevalent illnesses and causes of death, and variations in recipe types identified regionally and temporally. Detailed case studies of coughs and colds, gout, hydrophobia, diet drinks and Daffy’s Elixir illustrate the variety of ingredients and methods, as well as regimens for health and differences by gender and age. Examination of compilers and contributors of recipes demonstrates that both women and men were involved in this practice. Recipe exchange is delineated as a form of social currency requiring trust and reciprocity, and case studies show how knowledge circulated through three forms of network: familial, sociable and political. Finally, a major contribution of this thesis is that it identifies manuscript medical recipe collections as fulfilling four important functions for their compilers: oeconomic, symbolic, personalised and instrumental.
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Тюрменко, Ірина Іванівна. « Дмитро Семенович Ківа – будівничий цивільної авіації України ». Thesis, Національний авіаційний університет, 2010. http://er.nau.edu.ua/handle/NAU/11662.
Texte intégralRésumé :
Дмитро Семенович Ківа – визначний учений у галузі літакобудування, державний діяч
України – народився 8 жовтня 1942 р. у м. Казань (Росія). У своїй родині Дмитро Семенович став
першим, хто присвятив себе авіації. З раннього дитинства хлопець закохався у небо. Його мама
працювала вчителькою у школі поблизу Харківського авіаційного інституту (далі – ХАІ). У тій школі
було багато дітей із сімей викладачів ХАІ. Їх розмови про авіацію, захоплення конструюванням літаків
дуже приваблювало допитливого Дмитра. Тому юнак твердо вирішив, що буде вчитися тільки у ХАІ. У
1959 р. Д. Ківа вступив до цього навчального закладу. З перших років студентського життя він з
головою занурився у навчання, захопився науково-дослідною роботою, став активним членом
студентського конструкторського бюро ХАІ. Першим серйозним науковим випробуванням для Дмитра
стало конструювання та створення апарату на повітряній подушці (АПП-3). Д. Ківа не лише
змоделював і побудував апарат, а й сам провів серію випробувань. Під час одного з таких випробувань
відірвався гвинт... Сама доля врятувала життя юнаку. Однак безліч отриманих травм ще й досі даються
взнаки. Утім це не зламало його, не відштовхнуло від обраного шляху: «Було багато винаходів,
випробувань, травм, болі та величезне задоволення від здійсненого», – пригадував пізніше визначний
авіаконструктор. Безмежна відданість небу, потяг до нових відкриттів та звершень торували шлях в
авіацію.
33
Kakhi, Abolghasem. « La Connaissance des valeurs épiques et dramatiques dans le Livre des Rois ». Strasbourg 2, 2002. http://www.theses.fr/2002STR20027.
Texte intégralRésumé :
L'objet de notre thèse porte sur la valeur épique dramatique présente dans l'oeuvre de Ferdösĩ, le Šah-Nãme ou Livre des Rois. Ce monument de la littérature persane est en fait une vaste épopée où des qualités tels que l'héroi͏̈sme, le courage, l'honneur, le respect ou l'honnêteté sont exaltées. Dans un chapitre préliminaire, nous avons choisi de présenter de manière générale la vie de Ferdösĩ et les éléments biographiques qui ont pu influencer l'oeuvre de l'artiste. Puis, notre travail s'est orienté vers trois directions de recherche. Le premier concerne la valeur épique du livre des Rois. Celle-ci explicitée en analysant la signification de l'épopée et sa structure interne, l'aspect temporel et spatial, les différents types de narrations, le secret de la pérennité de l'oeuvre et les figures stylistiques employées par Ferdösĩ. Le deuxième axe de recherche présente les protagonistes du livre des Rois, la pesonnification, l'époque mythique, historique et héroi͏̈que, les contradictions, les corrélations et les conflits entre les personnages. Le troisième axe de recherche se rapporte à la coordination entre l'action et le langage théâtral, les sources d'inspiration du récit et des personnages, le rôle des mythes, le mouvement dramatique, le rythme et la transposition du récit. L'analyse s'achève sur le rythme épique et musical de l'épopée et la corrélation du langage de Ferdo͏̈sĩ avec la langage contemporainThe subject of our thesis is the dramatic and epic values presented at the Šãh-Nãme (the King's Book) by Ferdösĩ. This Persain literature masterpiece is foll of qualities such as heroism, braveness, honour, respect and honesty. .
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Müller-Rudolf, von Rohr Verena Schmid Lydia. « Soziale Arbeit im zivilrechtlichen Kindesschutz : eine Analyse ihrer Funktionen, Zielsetzungen und Legitimation / ». Bern : Ed. Soziothek, 2005. http://www.soziothek.ch/?3-03796-094-7.
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Trojanowski, Albin S. « Thermomechanical properties of polymers at high rates of strain ». Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:a2c20a83-094d-4293-8c5f-665640c1ce5a.
Texte intégralRésumé :
-1 were achieved when testing specimens and this rate was obtained using a split Hopkinson pressure bar. A substantial number of preliminary tests were conducted in order to obtain a suitable specimen size which was then used in the temperature measurement process. Quasistatic, intermediate and high strain-rate tests were performed; the last utilised the radiometer for temperature measurement. An Eyring plot was constructed from which fundamental values for activation volumes and enthalpies were obtained. Full descriptions of the testing techniques used have been included and a brief photoelastic analysis has been carried out on a partially deformed specimen which shows molecular alignment.
36
Muehlemann, Anton. « Variational models in martensitic phase transformations with applications to steels ». Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:bb7f4ff4-0911-4dad-bb23-ada904839d73.
Texte intégralRésumé :
This thesis concerns the mathematical modelling of phase transformations with a special emphasis on martensitic phase transformations and their application to the modelling of steels. In Chapter 1, we develop a framework that determines the optimal transformation strain between any two Bravais lattices and use it to give a rigorous proof of a conjecture by E.C. Bain in 1924 on the optimality of the so-called Bain strain. In Chapter 2, we review the Ball-James model and related concepts. We present some simplification of existing results. In Chapter 3, we pose a conjecture for the explicit form of the quasiconvex hull of the three tetragonal wells, known as the three-well problem. We present a new approach to finding inner and outer bounds. In Chapter 4, we focus on highly compatible, so called self-accommodating, martensitic structures and present new results on their fine properties such as estimates on their minimum complexity and bounds on the relative proportion of each martensitic variant in them. In Chapter 5, we investigate the contrary situation when self-accommodating microstructures do not exist. We determine, whether in this situation, it is still energetically favourable to nucleate martensite within austenite. By constructing different types of inclusions, we find that the optimal shape of an inclusion is flat and thin which is in agreement with experimental observation. In Chapter 6, we introduce a mechanism that identifies transformation strains with orientation relationships. This mechanism allows us to develop a simpler, strain-based approach to phase transformation models in steels. One novelty of this approach is the derivation of an explicit dependence of the orientation relationships on the ratio of tetragonality of the product phase. In Chapter 7, we establish a correspondence between common phenomenological models for steels and the Ball-James model. This correspondence is then used to develop a new theory for the (5 5 7) lath transformation in low-carbon steels. Compared to existing theories, this new approach requires a significantly smaller number of input parameters. Furthermore, it predicts a microstructure morphology which differs from what is conventionally believed.
37
Liu, Yang. « Privacy-preserving targeted advertising for mobile devices ». Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:c2c929cc-0931-457a-afff-d973624a356c.
Texte intégralRésumé :
With the continued proliferation of mobile devices, the collection of information associated with such devices and their users - such as location, installed applications and cookies associated with built-in browsers - has become increasingly straightforward. By analysing such information, organisations are often able to deliver more relevant and better focused advertisements. Although such Targeted Mobile Advertising (TMA) offers great benefits to advertisers, it gives rise to a number of concerns, with privacy-related concerns being prominent amongst them. It follows that there is a need for an advertisement-selection mechanism that can support the existing TMA business model in a manner that takes into account consumers' privacy concerns. The research described in this dissertation explores the delicate balance between the goals of the advertisers and the consumers: advertisers pursue profits by applying TMA, which violates consumers' privacy; consumers hope to benefit from useful mobile advertisements without compromising their personal information. The conflicts of interests between consumers and advertisers in the context of targeted mobile advertising brings us to our research question: Is it possible to develop a privacy-preserving TMA framework that enables mobile users to take advantage of useful advertising services without their privacy being compromised, and without impacting significantly advertising effectiveness? In order to answer this question, this dissertation presents four main contributions. First, we report upon the result of a qualitative study to discuss the balance that needs to be struck between privacy and utility in this emerging area. Second, a number of formal models are developed to reason about privacy, as well as to reason about the relationship between privacy and utility in the context of TMA. Third, a novel ad-selection architecture, PPTMA (Privacy-Preserving Targeted Mobile Advertising), is presented and evaluated. Finally, a privacy-preserving advertisement-selection mechanism, AdSelector, is introduced. The mechanism is novel in its combination of a user subscription mechanism, a two-stage ad-selection process, and the application of a trustworthy billing system.
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Pullen, Anne Jennifer. « Behavioural indicators of candidate enrichments for kennel housed dogs ». Thesis, University of Bristol, 2011. http://hdl.handle.net/1983/add992d2-09f1-4658-aedf-93198b620b3d.
Texte intégralRésumé :
The welfare of kennelled dogs is often considered to be suboptimal and therefore to require "enrichment". This thesis examines the short-term reactions of dogs to a variety of potential enrichments. Where possible, comparisons were also made between two contrasting kennel environments, to indicate to what degree interest in enrichments is influenced by environment, as well as fulfilling species requirements. Interaction with toys was investigated as an example of inanimate enrichment. Toys that made a noise and/or could be chewed easily were found to be preferred to more robust toys, suggesting that the latter may provide little enrichment. Interactions with humans and conspecifics were investigated as examples of animate enrichment. Dogs in long-stay enriched (LSE) kennels preferred unfamiliar humans to familiar, while those in rehoming (RH) kennels showed no overall preference: therefore, the welfare benefit of different forms of human contact is likely to differ between facilities. LSE dogs also behaved differently depending upon the familiarity of conspecifics, with the greeting period at the beginning of the interaction more important for unfamiliar dogs, suggesting that familiarity is also an important factor when considering the effectiveness of conspecific contact as enrichment. Comparing animate and inanimate enrichments, LSE dogs chose social contact (human or dog) over toys. However, their greatest interest was in the goings-on outside the pen. The rapid habituation that occurs towards individual objects during play was shown, by measuring dishabituation, to be due to the overall stimulus properties of the toy rather than those within any single sensory modality. The time interval between presentations did not appear to be critical to habituation or dishabituation. Behaviour indicating a switch from anticipation to frustration as enrichment is delayed was investigated but not determined. However, positive reinforcement training may have inhibited expression of frustration behaviour.
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Bregman, Tom P. « The impacts of human land-use change on avian diversity and associated ecosystem functions ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b0364847-0949-4d9f-bf2a-2cca62a988a7.
Texte intégralRésumé :
Understanding the impacts of land-use change on biodiversity and the ecosystem services that it provides is of great importance given unprecedented growth of the human population. Past studies attempting to explore these impacts have described the overall structure of communities (i.e. species richness and trait diversity) across gradients of local scale degradation and fragmentation, and have sought to identify whether the loss of species following land-use change is non-random. Yet, despite a wealth of research we still lack a generalised understanding of how land-use change impacts on traits responsible for determining species sensitivity and their role within ecosystems, particularly for vertebrates. Moreover, despite the importance of niche-based processes in the assembly of communities, we have not yet elucidated whether these are important in mediating the collapse of communities in human-dominated landscapes. To fill these existing research gaps, I collated comprehensive avian species inventories from fragmented and degraded forests and compared their structure with communities existing in continuous forests. In Chapter 2, I tested whether sensitivity of species to forest fragmentation varies between the temperate zone and the tropics and whether there are key differences in the size of fragments required to maintain ecosystem processes in these regions. I found that sensitivity to fragmentation varies according to functional group and body mass, with the prevalence of insectivores and large frugivores declining in relation to fragment size, particularly in tropical fragments smaller than 100 ha. In Chapter 3, I tested whether functional diversity and the mean position of trait diversity of insectivores and frugivores, changed across a gradient of intensifying land-use change. I found a decline in the functional diversity of forest species and a shift in the mean community traits for both forest and non-forest species. In Chapter 4, I tested whether the structure of tropical bird communities are influenced by species interactions in a fragmented landscape. I found increasing over-dispersion in functional and phylogenetic trait relatedness among species with decreasing fragment size, suggesting that competitive interactions are important in the disassembly of avian communities. In Chapter 5, I modelled the impact of forest cover change on ecosystem function across the Brazilian Amazon, focusing on seed dispersal by birds. Furthermore, I tested whether ecosystem function declined linearly with decreased forest cover after accounting for differences in the underlying pools of species. I found the lowest levels of functional diversity along the southern arc of deforestation and that the dispersal of large seeds showed some resilience to declining forest cover. Taken together, my results suggest that the loss of species from communities in degraded and fragmented landscapes is strongly non-random. Insectivores and large frugivores are most sensitive to land-use change, with species located in the densest parts of trait space being most threatened by a decline in forest patch size, suggesting that species interactions regulate the collapse of avian diversity in human-modified forests. I conclude that land-use change has important implications for the provisioning of ecosystem services, including seed dispersal and the control of insect herbivores. The impact of future land-use change is likely to be mediated by the composition of the original pool of species and the amount of redundancy in the ecosystem services that they provide. I discuss the relevance of my findings to land-use management strategies and policy interventions, and in particular conclude that these should, where possible, maintain pristine forest patches above 1000 ha, improve connectivity among habitat patches, and ensure greater protection for logged and burnt forests. Future studies should focus on clarifying the link between shifts in vertebrate community structure and the functioning of forest ecosystems.
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Gorla, Maria Cecilia Outeiro. « Resposta imune a uma vacina proteica antimeningococica B : estudo da influencia de intervalos de tempo entre as imunizacoes ». Sao Paulo : [s.n.], 2003. http://lildbi.bireme.br/lildbi/docsonline/lilacs/094-Tese%5FCIP%5FGorlaMCO.pdf.
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Siliņš, Ilvars. « Molecular epidemiology of human papillomavirus and cervical cancer / ». Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-091-1/.
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Ackermann, Paul. « Peptidergic innervation of periarticular tissue : a study in the rat / ». Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-094-6/.
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Niu, Xianzhi. « The functional role of the lateral olivocochlear system and mechanisms underlying sound conditioning / ». Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-094-X/.
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Hermansson, Liselotte. « Upper limb reduction deficiencies in Swedish children : classification, prevalence and function with myoelectric prostheses / ». Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-091-5/.
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Abgrall, Philippe. « Les développements de la géométrie au Xè siècle : la contribution d'al-Quhi ». Paris 7, 2002. http://www.theses.fr/2002PA070065.
Texte intégralRésumé :
Cette thèse de doctorat présente la première étude de synthèse de l'œuvre mathématique de l'un des plus grands géomètres du Xe siècle, Abu Sahl al-Quhi. Héritier de la géométrie hellénistique, il occupe une place de choix dans la double tradition, archimédienne et apollonienne, fondée un siècle plus tôt par les Banu Musa et achevée au XIe siècle avec Ibn al-Haytham, mise en évidence par le professeur Roshdi Rashed dans ses recherches des dix dernières années. AI-Quhi a laissé des travaux dans presque tous les domaines d'activité que la géométrie a connus au Xe siècle. Il a aussi bien participé à l'approfondissement de chapitres anciens, comme les constructions géométriques ou l'étude et l'application des sections coniques, qu'à l'examen des transformations géométriques en tant que telles, ou à la création de nouveaux chapitres comme celui des projections. A travers cette étude qui présente l'édition critique en arabe, la traduction en français et le commentaire de trois de ses traités ainsi que d'une correspondance scientifique qu'il a eu avec al-Sabi', il apparaît que l'activité d'al-Quhi a été innovante et a joué un rôle déterminant dans les développements de la géométrieThis Ph D Thesis presents the first synthesis about one of the biggest geometers' mathematical works in the l0th century, Abu Sahl al-Quhi. Heir of the hellenistic geometry, he takes a great place in the double tradition, archimedean and apollonean, being begun a centuty earlier by the Banu Musa and being fmished in the 11th century with Ibn al-Haytham, revealing by the professor Roshdi Rashed in its researches for the last ten years. Al-Quhi left works in almost all the fields of activity which the geometry knew during the l0th century. He took part as well in the extension of ancient chapters, as the geometrical constructions or the study and the application of the conic sections, as on examination of the geometrical transformations, or in the creation of new chapters as that of the projections. Ln sight of this study which presents the critical edition in Arabic, the translation in French and the comment of three of its treaties as well as a scientific correspondence that he had with al-Sabi', it appears that al-Quhi's activity was innovative and played a determining role in the developments of the geometry
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Alami, Ahmed. « La pensée mu'tazilite et la philosophie : l'ontologie bahsamite ». Paris 1, 1988. http://www.theses.fr/1988PA010588.
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Al-Yamini fi At-Tarikh est l'œuvre historique la plus célèbre du début de l'époque Ghaznavide en notre possession. Abu An-Nasr Muhammad Al-Utbi naquit à Ray, dans le Fars, et mourut en 427 1037. Al-Yamini fut écrit vers 412 1020 et dédié au vizir al-Mimandi. Il en existe plusieurs copies de cette histoire dont sept à la Bibliothèque nationale de Paris. La plus ancienne (fonds arabe no 1894) a servi de base à cette étude. Une préface et un chapitre sont consacrés à la situation politique dans l'empire de l'Islam. Plusieurs chapitres traitent des évènements qui aboutirent à la création de l'état Ghaznavide et à l'avènement de Subuktikin. Ceux-ci se terminent par la mort de l'émir (387 997) et la description de la guerre de succession. Al-Utbi feint ignorer toute la période entre la mort d'Alptikin (352 963), le fondateur de la principauté de Ghazna, et le règne de Subuktikin (365 977), mais nous avons tente de combler cette lacune. Dans cette partie il s'est avéré utile de relater l'histoire des derniers samanides et le début des qarakhanides. Les chapitres relatifs aux expéditions et aux conquêtes du sultan Mahmud en Inde et ailleurs vont au-delà du récit d'Al-Utbi, qui cesse brutalement en 410 1019. Un chapitre traite des expéditions non rapportées par Al-Yamini. La dernière partie relate la vie et l'œuvre du sultan MahmudAl-Yamini fi at-tarikh is the most copious history of the beginning of the ghaznawid dynasty, we possess. Abu an-nasr muhammad al-utbi was borned in ray, in fars, he was dead in 427 1037. The ghaznawid's history was written, about 412 1020, and dedicated to the vizir al-mimandu. Copies of this history are common, there are seven in the bibliotheque nationale de paris, the oldest (fonds arabe no 1894) have been used for our work. The study of sultan mahmud's conquests commences with a preface devoted to the general political situation in the muslim world. Many chapters contain an account of the events which led to the advent of subuktikin, and closed with his death (387 997). Al-utbi has omitted all notices of the 13 years which elapsed between the death af alptikin (352 963) the founder of the principality of ghazna and the advent of subuktikin (365 977). But we attempt to remedy this lacuna. We mention at the end that we was induced to give an account of the reigns of the last samanids. It also contains an account of the beginning of a turish dynasty : the qarakhanids. Others parts are devoted to the sultan mahmud's operations in the north of india up to 410 1019, but we have continued until the conquest of somnath (416 1025). It contains a brief account of the indian dynasties. The last chapters are about the sultan mahmud's life and works in his great empire from fars to kanauj
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Young, Katherine S. « Adults' responses to infant vocalisations : a neurobehavioural investigation ». Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:6f91f1ae-0948-4b34-b45f-ee65ae421934.
Texte intégralRésumé :
Infant vocalisations are uniquely salient sounds in the environment. They universally attract attention and compel the listener to respond with speed and care. They provide a wealth of information to parents about their infant’s needs and affective state. There is a scientific consensus that early parenting has a profound impact on child development. In particular, the sensitivity with which parents respond to their infant’s communicative cues has been shown to affect cognitive and socio-emotional outcomes. The mechanisms underlying such sensitivity are not well understood. In this thesis, adults’ sensitivity to infant cues will be considered in terms of two components, the ‘promptness’ and ‘appropriateness’ of responses, as originally conceptualised by Bell and Ainsworth (1972). Promptness of responses is considered in terms of adults’ ability to move with speed and effort after listening to infant vocalisations. Appropriateness, on the other hand, is considered in terms of adults’ ability to differentiate between functionally significant parameters in infant vocalisations. The effect of modifiable environmental factors on the promptness and appropriateness of responses is also investigated. Finally, a focused investigation of the brain basis of responses to infant vocalisations is presented. Overall, findings demonstrated that infant vocalisations undergo privileged, specialised processing in the adult brain. After hearing an infant cry, adults with and without depression were found to move with greater coordination and effort. Adults were also found to be attuned to subtle parameters in infant cries. This sensitivity was shown to be affected by two participant-level factors, depression and previous musical training. Furthermore, this sensitivity could be enhanced through intervention, as evidenced by findings from short-term, perceptual discrimination training. The notion of privileged processing of infant vocalisations is further supported by evidence of early discrimination of infant sounds in a survival-related subcortical brain structure. Future directions for this work include directly relating current experimental measures of adults’ responses to infant cues with parental sensitivity to infant communication during dynamic interactions. Translating current findings into applied settings would require an investigation of the effects of factors such as musical and perceptual training on sensitivity to infant cues in at-risk populations, such as mothers and fathers with depression. Lastly, an increased understanding of the brain basis of adults’ sensitivity to infant cues will provide insight into our greatest challenge: parenting our young.
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Brown, Ruth Katharine. « The rise of the leisure painter : artistic creativity within the experience of ordinary life in postwar Britain, c. 1945-2000 ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4f9bec84-094e-4ec9-b36a-3b66e9330076.
Texte intégralRésumé :
Since John Ruskin and William Morris's protestations against mass production in the nineteenth century, critics of mass consumption thought that it not only reduced the necessity, but also the desire, to make things for personal use and enjoyment. The history of leisure painting in art societies and adult education, and of the amateur artist’s consumption of art materials and self-help literature, shows that, on the contrary, affluence both inspired and facilitated a quest for self-actualisation amongst the rank and file. Creative activities such as drawing and painting served this quest at little financial cost to the individual. Following the Second World War, a significant increase in the take-up of leisure painting was encouraged by the state as part of the broader postwar settlement. The pursuit of personal wellbeing through creative activity was regarded as a public good, of benefit not only to individuals but also to the communities of which they were a part. In the last quarter of the twentieth century, state support for recreational pursuits such as leisure painting was pared back: in the shift from collectivist social democracy towards individualist market liberalism, personal enjoyment was recast as a private affair for which the consumer must pay. Painting continued to grow in popularity, supported by expanding consumer markets in self-help literature and affordable art materials. Yet while consumerism sustained the popularity of amateur art-making, the ways in which amateur artists participated in the arts changed. Personal creativity emerges here as an inherently social activity: the private experience of creativity is mediated and structured by society. Consumerism was not bad for personal creativity per se, but the replacement of a communitarian approach with a consumerist model restricted the breadth and reach of creative aspiration nurtured as part of the postwar settlement. By the end of the century, most amateurs were painting alone.
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Hirschfeld, Marin. « Intimacy in contemporary digital cinema ». Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:8e212865-09d1-4bf7-bf05-76806a2e1e21.
Texte intégralRésumé :
Critical discourses on contemporary digital cinema tend to be either overtly negative, framed within a rhetoric of loss or disenfranchisement, or unilaterally positive, celebrating the user agency and freedom digital technologies enable. Both these conceptual positions are unhelpful because they either focus on what contemporary digital cinema fails to do or what it should do, without examining more closely how it actually functions. What is needed is a third, neutral approach which takes both sides into consideration but is also aware of their limitations and weaknesses. This thesis takes as its impetus Giles Deleuze’s suggestion that, just like the cinemas of the movement-image and the time-image before it, contemporary digital cinema needs a basic will to art – a new aesthetic principle, a new function of the image, a new politics, a new representational potential distinct from those that have come before it. The aim of this thesis is therefore to establish this will to art and explore its ramifications for and manifestations in contemporary digital cinema. Taking into consideration a variety of filmic texts from the 1980s to the present day which prominently feature diegetically recorded footage, as well as amateur film-making practices from the home movies of the 1960s to the video clips now uploaded to online media sharing platforms, the increasing relevance of home media in the reception of contemporary digital cinema, and most crucially the process of convergence inherent in digital media, this thesis argues that the will to art of contemporary digital cinema is intimacy.
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Swenson, Sarah A. « A gene's eye vew : W.D. Hamilton, the science of society, and the new biology of enlightened self-interest, 1950-1990 ». Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:4c979713-0911-4cc0-9a7f-05fb0455f128.
Texte intégralRésumé :
W.D. Hamilton has been celebrated as the twentieth-century Darwin. His extension of evolutionary theory to explain social behaviours has been extensively documented. Current accounts, however, have often overlooked the extent to which his early research goals were tied to his desire to see that a better world was created through a scientific understanding of society. In fact, when his interests in humans, and especially his eugenic concerns, have been acknowledged, they have been distanced from his scientific achievements and treated separately. Using new sources to reexamine the development of Hamilton’s most famous idea, the theory of inclusive fitness, we may better understand how his perception of cultural upheaval shaped his reading of social behaviours as evolved characters following universal laws. Understanding this, we may see that however successful Hamilton was, he never realized his original dream, which was to devise a theory that would inform the human world, replacing religious and ideological beliefs. As he sought to solidify his career in the 1970s, he moved away from publicly disclosing his more controversial ideas. This meant that by the time the science of social behaviour inspired heated debates, he was almost always absolved from political critiques. Many assumed that his theory was derived from observations of insects, and his eugenic ideas were forgotten, ignored, or not understood. He was therefore well positioned to become the objective figurehead of a new discipline, sociobiology. This does not mean that his desire to understand society as the result of genetic laws subsided, and by placing inclusive fitness against its social and political background, we might reimagine its trajectory and its impact in new ways. We might also begin to see Hamilton not as an isolated scholar unengaged with society but as an individualist whose extra-scientific beliefs paralleled his scientific theories in meaningful ways.