Literatura académica sobre el tema "Zi dong hua bu"

Abstract In this study, we investigated the underlying mechanism of action of methyl-cantharidimide (MCA), a cantharidin (CTD) analog, as an anticancer drug, in resistant cancer cells overexpressing either ABCB1 or ABCG2 and in cisplatin-resistant cancer cells. The results indicated that: (i) MCA was efficacious in the ABCB1-overexpressing cell line, KB-C2, the ABCG2-overexpressing cell line, NCI-H460/MX20 and in the cisplatin resistant cancer cell lines, KCP-4 and BEL-7404/CP20; (ii) MCA induced apoptosis in both BEL-7404 and BEL-7404/CP20 cancer cells and arrested both BEL-7404 and BEL-7404/CP20 cancer cells in the G0/G1 phase of the cell cycle; (iii) MCA upregulated the expression level of the protein, unc-5 netrin receptor B (UNC5B) in HepG2 and BEL-7404 cancer cells. (iv) MCA can activate UNC5B-Netrin-1-DAPK apoptosis pathway in hepatocellular carcinoma cells. Overall, our results indicated that MCA's efficacy in multiple cancer cell lines is due to the activation of UNC5B-Netrin-1-DAPK apoptosis pathway and cell cycle arrest in the G0/G1 phase. Citation Format: Yi-Dong Li, Yong Mao, Xing-Duo Dong, Zi-Ning Lei, Yuqi Yang, Lizhu Lin, Dong-Hua Yang, Zhe-Sheng Chen. Methyl-cantharidimide (MCA) can induce apoptosis by activating UNC5B-Netrin-1-DAPK pathway in hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 360.

Abstract While topotecan (TPT) is a chemotherapeutic drug in treating lung cancer, the development of TPT resistance in tumors reserves as a major obstacle to chemotherapeutic success. Therefore, a better understanding of the mechanisms of TPT resistance is critical. In this study, the first topotecan-resistant human non-small cell lung cancer (NSCLC) cell line, termed NCI-H460/TPT10, was established from the parental NCI-H460 cell line. NCI-H460/TPT10 cells exhibited a 394.7-fold resistance to TPT, and cross-resistance to SN-38, mitoxantrone, and doxorubicin, compared to parental NCI-H460 cells. Overexpression of ABCG2 localized on the cell membrane, but not ABCB1 or ABCC1, was found in NCI-H460/TPT10 cells, indicating that ABCG2 was likely to be involved in TPT-resistance. This was confirmed by the abolishment of drug resistance in NCI-H460/TPT10 cells after ABCG2 knockout. Moreover, the involvement of functional ABCG2 as a drug efflux pump conferring multidrug resistance (MDR) was indicated by low intracellular accumulation of TPT in NCI-H460/TPT10 cells, and the reversal effects by ABCG2 inhibitor Ko143 and cabozantinib. The NCI-H460/TPT10 and its parental cell line were further used to establish in vivo tumor xenograft mouse models, which verified their capability to serve as clinically relevant models for drug screening and the development of targeted strategies to overcome ABCG2-mediated MDR in NSCLC. Citation Format: Qiu-Xu Teng, Zi-Ning Lei, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Dong-Hua Yang, John Wurpel, Zhe-Sheng Chen. Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1095.

How should nature be written? Writing has long been a way for people to understand nature. Still, we have come to an age that we need to reconceptualize our relation with nature. Nature can no longer be regarded as a passive stage upon which human beings act. How should we understand nature so that nature is made inanimate? I propose that the solution, known as “Schizo-Natural Writing,” can be found in Dung Kai-cheung’s Natural Histories Trilogy. Hong Kong is commonly seen as a city. Correspondingly, when it comes to Hong Kong literature, the term appears frequently will be “city writing”. It is not surprising, given that Hong Kong has always been recognised as a highly-developed city, one of the most densely populated cities in the world. Famous literary works in Hong Kong like Xi Xi’s My City (西西，我城), A Dictionary of Two Cities co-written by Hon Lai Chu and Dorothy Tse Hiu Hong (韓麗珠、謝曉虹，雙城辭典), Wong Bik Wan’s The City of Lost (黃碧雲，失城), just to name some. This phenomenon is closely related to the historical background of Hong Kong. According to Chan (2009), the connection between Hong Kong literature and its cityscape can be dated back to 1950s. Though it does not mean that there are no non-urban writings, those were not in the mainstream. However, in 2000s one of the most influential local writers, Dung Kai Cheung (1967 -), has begun his Natural Histories Trilogy. He is the director in The House of Hong Kong Literature, a folk organisation of local literature. His publication includes, Androgyny: Evolution of a Non-existent Species (1996), a story about a female scientist who went into the wild and sought a nonexistent species, named as androgyny and Atlas: The Archaeology of an Imaginary City (1997), an imaginary archaeology in the future Hong Kong, which has been translated into English. During 2005 to 2010, he published the Natural Histories Trilogy, including firstly, the History of the Adventures of Vivi and Vera (2018, which titled in Chinese, 天工開物．栩栩如真), secondly, the Histories of Time: The Light of Nga Chi (2007, 時間繁史．啞瓷之光) and thirdly, on the Origin of Species: The Rebirth of Bui Bui - The Age of Apprenticeship (2010, 物種源始．貝貝重生 之 學習年代). In the trilogy, Dung Kai-cheung, echoing Deleuze and Guattari’s notion of “nature=industry”, highlighted the productivity of nature, or the naturing of nature. As such, he no longer writes nature. He writes schizo-naturally. I further adopted the term “ecology”, which on the one hand pointed out the close relation between the item produced during the schizo-natural writing; on the other hand, echoed Guattari’s the Three Ecology. In this thesis, there are four parts investigating four types of ecology: mental ecology, social ecology, environmental ecology and spatiotemporal ecology. Through examining the trilogy, love, being standing outside oneself, is advocated to be the way out of the fragmented world. Keywords: Dung Kai-cheung, the Natural Histories Trilogy, nature writing, Gilles Deleuze, Ecology