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Literatura académica sobre el tema "Xantine"

Autor: Grafiati

Publicado: 11 de marzo de 2023

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Artículos de revistas sobre el tema "Xantine"

Suwandi, Deden Winda y Farid Perdana. "AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE EKSTRAK ETANOL DAUN ALPUKAT (Persea americana MILL) SECARA IN VITRO". Jurnal Ilmiah Farmako Bahari 8, n.º 2 (27 de julio de 2017): 40. http://dx.doi.org/10.52434/jfb.v8i2.784.

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Hiperurisemia merupakan keadaan berlebihnya kadar asam urat dalam darah disebabkan oleh ketidak seimbangan antara produksi dan ekskresi asam urat dalam tubuh. Kondisi ini dapat menimbulkan penyakit gout yang ditandai pengendapan kristal monosodium urat. Salah satu obat yang digunakan untuk menurunkan kadar asam urat adalah allopurinol dengan cara menghambat aktivitas xantine oxidase sebagai enzim pembentuk asam urat. Penggunaan obat tradisional seperti tumbuhan alpukat yang mengandung flavonoid diduga memiliki aktivitas antihiperurisemia karena dilaporkan bahwa senyawa flavonoid dapat menurunkan kadar asam urat darah dengan cara menghambat aktivitas xantin oksidase. Telah dilakukan penelitian terhadap ekstrak etanol daun alpukat dalam menghambat aktivitas xantin oksidase sehingga bisa digunakan sebagai obat penyakit gout. Aktivitas penghambatan enzim xantin oksidase oleh ekstrak etanol daun alpukat secara invitro ditentukan melalui penurunan produksi asam urat yang diukur dengan alat spektrofotometer pada (λ) 293 nm dengan xantin sebagai substrat. Ekstrak etanol daun alpukat dapat menghambat enzim xantin oksidase pada pada konsentrasi 40; 60; 80; 100 dan 120 ppm dengan persen penghambatan sebesar 27,97; 51,98; 64,07; 71,15 dan 77,54 %. Aktivitas penghambatan xantin oksidase ekstrak daun alpukat ditentukan dengan nilai IC50, dimana hasilnya menunjukkan ekstrak etanol daun alpukat mampu menghambat aktivitas xantin oksidase dengan IC50 65,55 ppm yang lebih lemah bila dibandingkan dengan IC50 allopurinol yaitu sebesar 0,59 ppm. Kata kunci: Hiperurisemia, daun alpukat, penghambatan xantin oksidase.

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Husein, Sri Gustini, Achmad Zainuddin y Sani Hoeruman. "Synthesis N1-Tersier-Butilteobromin from Teobromin and Tersier-Butylbromides". Indonesian Journal of Pharmaceutical Science and Technology 5, n.º 3 (1 de octubre de 2018): 93. http://dx.doi.org/10.24198/ijpst.v5i3.17931.

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Xantine derivatives are known to have some pharmacological activity, such as a bronchodilator. The substitution on atoms N1 xantine can improve the activity and selectivity as a tracheaspasm. The purpose of this research was to investigate the influence of concentration sodium hydroxide in sodium acetate as solvent used on the production yield of N1-tert-butilteobromin. The result of the synthesis was isolated using chloroform and purified with the preparative thin layer chromatography. The molecule structure of N1-tert-butilteobromin was confirmed using ultraviolet and infrared spectrophotometry. The result showed that sodium hydroxide concentration could effect the results of yield. The yields of 4%, 8%, and 12% sodium hydroxide concentration were 3.7% (0.074 g), 7.2% (0.144 g), and 1.3% (0.026 g), respectively.Keywords: N1-tert-butylteobromin, sodium hydroxide, tert-butylbromide, theobromine

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Kamilov, F. Kh, G. A. Timirkhanova, A. I. Samorodova, A. V. Samorodov, F. A. Khaliullin y D. Z. Murataev. "Antiaggregatory activity of new 1-ethylxanthine cyclohexylammonium salt in vitro". Kazan medical journal 94, n.º 5 (15 de octubre de 2013): 692–95. http://dx.doi.org/10.17816/kmj1921.

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Aim. To study the biochemical effect on hemostasis of a new cyclohexilammonium salt of 2-[1-ethyl-3-methyl-7(dioxotiethanyl-3)xantinyl-8-thio]acetic acid in vitro. Methods. Thromboelastography was performed using the citrate blood samples of healthy male donors. Global hemostatic effect, fibrinogen and platelet function, fibrinolysis and clot strength, and stability were analyzed at thromboelastography. The impact of firstly synthesized xantine derivative and pentoxifylline on the functional activity of platelets in vitro was studied using a laser analyzer of platelet aggregation. Adenosine diphosphate, collagen, epinephrine and ristocetin induced clotting were registered. General clotting characteristics, maximal aggregation values, maximal aggregation speed, mean platelet aggregate size, activity of platelet-derived factor 3, level of platelet-derived factor 4 were measured. Release of platelet-derived factors 3 and 4 at platelet aggregation were assessed after adenosinediphosphate-induced aggregation and centrifugation. Results. Cyclohexylammonium salt of 2-[1-ethyl-3-methyl-7-(dioxotiethanyl-3)xantinyl-8-thio]acetic acid in vitro showed antiaggregatory activity that exceeds such of pentoxifylline. It has been revealed that the second platelet aggregation wave, that is induced by small dose of adenosinediphosphate, is absent in the presence of the new cyclohexylammonium salt, lag-period in collagen-induced platelet aggregation elongates, and availability and release of platelet-derived factors 3 and 4 decreases. Conclusion. The research findings show potentially high antiaggregatory activity of 2-[1-ethyl-3-methyl-7-(dioxotiethanyl-3)xantinyl-8-thio]acetic acid cyclohexylammonium salt as an inhibitor of platelet release reaction.

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Kamilov, F. Kh, G. A. Timirkhanova, A. I. Samorodova, F. A. Khaliullin y R. A. Gubaeva. "Features of hemostatic activity of 2-[3-methyl-1-h-propyl-7-(1,1-dioxothiethanyl-3) xantinyl-8-thio] acetic acid cyclohexilammonium salt". Kazan medical journal 94, n.º 4 (15 de diciembre de 2013): 549–52. http://dx.doi.org/10.17816/kmj1969.

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Aim. To study the systemic hemostatic activity of firstly synthesized 2-[3-methyl-1-h-propyl-7-(1,1-dioxotiethanyl-3) xantinyl-8-thio] acetic acid cyclohexilammonium salt in vitro and in vivo. Methods. Experiments in vitro using the blood samples form healthy male donors, and in vivo on male rats by intraperitoneal injection of the equimolar concentrations of researched substances. The effect of the firstly synthesized xantine and etamsylate derivative on the platelet functional activity in vitro and in vivo was studied using a platelet aggregation laser analyzer «Biola 230 LA» (Russia). 20 mkg/ml of adenosinediphosphate and 5 mg/ml of collagen (produced by «Technologia-Standart» company, Russia) were used as an aggregation inducers. Aggregation was analyzed using the AGGR software. General aggregation parameters, maximal aggregation value, maximal aggregation speed, average size of platelet aggregates were analyzed. Experimental assessment of specific systemic hemostatic activity in vivo was made in accordance with the parenchymal hemorrhage model on mature male rats. Coagulation time and blood loss volume were registered. Results. 2-[3-Methyl-1-h-propyl-7-(1,1-dioxotiethanyl-3) xantinyl-8-thio] acetic acid cyclohexilammonium salt showed a pro-aggregative effect both in vitro and in vivo. 2-[3-Methyl-1-h-propyl-7-(1,1-dioxotiethanyl-3) xantinyl-8-thio] acetic acid cyclohexilammonium salt pro-aggregative effect which was observed both in vitro and in vivo increased the systemic hemostatic activity, exceeding the results of the control group and etamsylate group. Conclusion. The findings reveal potentially high systemic hemostatic activity of 2-[3-methyl-1-h-propyl-7-(1,1-dioxotiethanyl-3) xantinyl-8-thio] acetic acid cyclohexilammonium salt and confirm the need for further studies of this compound and its equivalents in order to create highly effective selective hemostasis correctors on their basis.

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Orhan, Ilkay E. "Natural Products and Extracts as Xantine Oxidase Inhibitors - A Hope for Gout Disease?" Current Pharmaceutical Design 27, n.º 2 (2021): 143–58. http://dx.doi.org/10.2174/18734286mta4lntc95.

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Rohmat, Muhammad Lathiful Hidayatul y Nuniek Herdyastuti. "REVIEW ARTIKEL: ISOLASI DAN PENGUKURAN AKTIVITAS ENZIM XANTIN OKSIDASE". Unesa Journal of Chemistry 10, n.º 1 (25 de enero de 2021): 96–108. http://dx.doi.org/10.26740/ujc.v10n1.p96-108.

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Abstrak. Xantin oksidase adalah enzim yang mengkatalisis oksidasi hipoxantin menjadi xantin dan kemudian xantin menjadi asam urat yang memerankan peran penting dalam katabolisme purin. Xantin oksidase dapat diisolasi dari berbagai sumber susu, jaringan hewan, dan mikroorganisme baik mesofilik maupun termofilik. Pemurnian enzim xantin oksidase untuk mendapatkan aktivitas enzim yang tinggi telah dilakukan dengan berbagai metode antara lain, presipitasi amonium sulfat, dialisis, dan berbagai macam metode kromatografi. Pengukuran aktivitas enzim xantin oksidase dapat dilakukan secara in vintro dengan mengukur kadar produk ataupun kadar substrat yang beraksi. xantin oksidae berpotensi diaplikasikan dalam bidang medis sebagai kit, bidang industri sebagai biosensor dan penyiapan makanan sehat rendah purin, serta dalam bidang lingkungan hidup sebagai bioremediasi senyawa heterogen siklik yang berbahaya. Kata kunci: Xantin oksidase, isolasi, pengukuran aktivitas, aplikasi Abstract. Xanthine oxidase is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then xanthine to uric acid which be an important role in purine catabolism. Xanthine oxidase can be isolated from various sources of milk, animal tissue, and mesophilic and thermophilic microorganisms. Purification of xanthine oxidase to obtain high enzyme activity has been carried out by various methods include ammonium sulfate precipitation, dialysis, and various chromatographic methods. Measurement of xanthine oxidase enzyme activity can be doing by in vitro with measuring product levels or substrate levels in action. xanthine oxide has the potential to be applied in the medical field as a kit, in the industrial field as a biosensor and preparation of low purine healthy foods, as well as in the environmental field as a bioremediation of dangerous cyclic heterogeneous compounds. Keywords: Xanthine oxidase, isolation, activity measurement, application

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Borghi, Claudio, Krzysztof Narkiewicz y Giuseppe Mancia. "Uric acid and xantine-oxidase inhibitors in patients with gout: A re-assessment and an update". Cardiology Journal 26, n.º 1 (14 de marzo de 2019): 99–101. http://dx.doi.org/10.5603/cj.2019.0015.

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Aleksandrova, K. V., Ye S. Pruhlo, Ye K. Mykhalchenko, O. S. Shkoda y O. Yu Cherchesova. "Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines". Current issues in pharmacy and medicine: science and practice 15, n.º 3 (15 de noviembre de 2022): 266–70. http://dx.doi.org/10.14739/2409-2932.2022.3.253385.

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Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary obesity. After all, type 2 diabetes is included in the list of pathologies of the metabolic syndrome, it is important to find ways to alleviate the disease. Derivatives of such a heterocyclic system as xanthine are of great interest in this aspect. The aim of the study was to explore the hypoglycemic activity of newly synthesized water-soluble derivatives of 3-benzyl-8-substituted xanthines. Materials and methods. We obtained water-soluble potassium 3-benzyl-8-R-xanthin-7-ides, the structure and individuality of which were confirmed by a set of physical-chemical studies. Results. The hypoglycemic effect of the newly synthesized compounds was assessed by an oral glucose tolerance test. The obtained data were processed using modern statistical in silico-methods. Conclusions. The results of the hypoglycemic activity study among the potassium salts of 3-benzyl-8-substituted xanthine derivatives showed, that some new compounds are in close vicinity to the reference drug’s hypoglycemic action.

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Lemos, Agostinho, Ana Sara Gomes, Joana B. Loureiro, Pedro Brandão, Andreia Palmeira, Madalena M. M. Pinto, Lucília Saraiva y Maria Emília Sousa. "Synthesis, Biological Evaluation, and In Silico Studies of Novel Aminated Xanthones as Potential p53-Activating Agents". Molecules 24, n.º 10 (22 de mayo de 2019): 1975. http://dx.doi.org/10.3390/molecules24101975.

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Xanthone scaffold has been regarded as an attractive chemical tool in the search for bioactive molecules with antitumor activity, and in particular two xanthone derivatives, 12-hydroxy-2,2-dimethyl-3,4-dihydro-2H,6H-pyrano [3,2-b]xanthen-6-one (4) and 3,4-dimethoxy-9-oxo-9H-xanthene-1-carbaldehyde (5), were described as a murine double minute 2 (MDM2)-p53 inhibitor and a TAp73 activator, respectively. The xanthone 5 was used as a starting point for the construction of a library of 3,4-dioxygenated xanthones bearing chemical moieties of described MDM2-p53 inhibitors. Eleven aminated xanthones were successfully synthesized and initially screened for their ability to disrupt the MDM2-p53 interaction using a yeast cell-based assay. With this approach, xanthone 37 was identified as a putative p53-activating agent through inhibition of interaction with MDM2. Xanthone 37 inhibited the growth of human colon adenocarcinoma HCT116 cell lines in a p53-dependent manner. The growth inhibitory effect of xanthone 37 was associated with the induction of G1-phase cell cycle arrest and increased protein expression levels of p53 transcriptional targets. These results demonstrated the potential usefulness of coupling amine-containing structural motifs of known MDM2-p53 disruptors into a 3,4-dioxygenated xanthone scaffold in the design of novel and potent p53 activators with antitumor activity and favorable drug-like properties. Moreover, in silico docking studies were performed in order to predict the binding poses and residues involved in the potential MDM2-p53 interaction.

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Ferrari, Fernanda Cristina, Rita de Cássia Lemos Lima, Zilma Schimith Ferraz Filha, Camila Helena Barros, Marcela Carolina de Paula Michel Araújo y Dênia Antunes Saúde-Guimarães. "Effects of Pimenta pseudocaryophyllus extracts on gout: Anti-inflammatory activity and anti-hyperuricemic effect through xantine oxidase and uricosuric action". Journal of Ethnopharmacology 180 (marzo de 2016): 37–42. http://dx.doi.org/10.1016/j.jep.2016.01.007.

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Más fuentes

Tesis sobre el tema "Xantine"

Bolcato, Chiara. "Progettazione sintesi e valutazione biologica di sistemi eterociclici quali antagonisti per i recettori adenosinici. Validazione di modelli recettoriali". Doctoral thesis, Università degli studi di Trieste, 2008. http://hdl.handle.net/10077/2567.

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2006/2007
La tesi illustra il lavoro di dottorato mirato allo sviluppo di nuovi antagonisti adenosinici attivi nei confronti dei vari sottotipi recettoriali del ligando naturale Adenosina.
XX Ciclo
1977

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Retamoso, Leandro Thies. "PAPEL DO SISTEMA PURINÉRGICO E DOS RECEPTORES DE POTENCIAL TRANSITÓRIO VANILOIDE 1 (TRPV 1) NA DOR MUSCULAR TARDIA APÓS EXERCÍCIO EXCÊNTRICO EM RATOS". Universidade Federal de Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/6715.

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Chronic exercise has been recommended as a strategy for preventing several diseases associated with lifestyle such as heart disease, hypertension, osteoporosis and type II diabetes. Although regular physical exercise has benefits for health, all sports practitioners, and even sedentary people, have already feel delayed onset muscle soreness (DOMS) once, characterized by discomfort in skeletal muscle. As the most DOMS generator, acute eccentric exercise induce fatigue, strength reduction and performance impairment. Despite some researches demonstrating reactive oxygen species (ROS) in this context, there are few information about purine degradation as well as transient receptor potential vanilloid 1 (TRPV1) on DOMS development. In this context, animals performed a downhill running test (eccentric exercise) on treadmill until exhaustion for histologic evaluation, mechanical allodynea, strength force test and biochemical analysis. The results showed an increase in mechanical allodynea and ADP, AMP, uric acid and TRPV1 immunoreactivity levels. In conclusion, the results support the contribution of ROS and the participation of purine and TRPV1 on delayed onset muscle soreness.
O exercício físico crônico tem sido recomendado como estratégia para a prevenção de diversas doenças associadas ao estilo de vida, como doenças cardíacas, hipertensão, osteoporose e diabetes tipo 2. Embora o exercício físico regular traga benefícios para a saúde, todos os praticantes de atividade física e esporte e, até mesmo indivíduos sedentários, já experimentaram alguma vez na vida um episódio de dor muscular tardia (DMT), caracterizada pela sensação de desconforto na musculatura esquelética. Como grande gerador de DMT, destaca-se o exercício excêntrico agudo que induz fadiga, redução de força e perda de desempenho. Apesar de diversos estudos demonstrando a participação das espécies reativas de oxigênio neste quadro, pouco se sabe sobre a participação da degradação das purinas bem como a participação dos receptores de potencial transitório vaniloide 1 (TRPV1) no desenvolvimento da dor muscular tardia. Para tanto, os ratos wistar machos realizaram teste de downhill em esteira (exercício excêntrico) até a exaustão. Após foram analisados os danos histológicos nos músculos gastrocnêmio e sóleo, Outro set de animais após a exaustão foram avaliados nos testes de alodinea mecanica na pata traseira direita, teste funcional de força nas pastas dianteiras e análises bioquímicas no músculo gastrocnêmio. Os resultados demonstram aumento na alodinea, na carbonilação protéica, nos níves de ADP, AMP, ácido úrico, além de elevar os níveis de immureatividade do receptor TRPV1 e atividade da xantina oxidase. Esses dados apontam uma possível contribuição das espécies reativas de oxigênio, da degradação de purinas e dos receptores TRPV1 na dor muscular tardia.

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Sobral, Ivoneide Santana. "Estudo químico e da atividade antimicrobiana do caule da Kielmeyera cuspidata". Programa de Pós-Graduação em Química da UFBA, 2006. http://www.repositorio.ufba.br/ri/handle/ri/9997.

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O presente trabalho relata a investigação fitoquímica da espécie Kielmeyera cuspidata, pertencente à família Clusiaceae. Este é o primeiro estudo fitoquímico desta espécie. A coleta do material ? caule e folhas ? foi feita na região da Chapada Diamantina no município de Andaraí, estado da Bahia. Do extrato hexânico e da fase diclorometano do extrato metanólico do caule da K. cuspidata foram obtidas dez substâncias. Sendo que no extrato hexânico foi identificado uma mistura de esteróides (acetato de sitosterol e acetato de estigmasterol). Já na fase diclorometano foi identificada uma mistura de triterpenos (a-amirina e b-amirina) e seis xantonas. Na determinação estrutural das substâncias isoladas, foram utilizados métodos espectrométricos usuais; UV, RMN e espectro de massas, juntamente com comparação dos dados descritos na literatura. Foram realizados também testes de atividade antimicrobiana nos extratos trabalhados.
Salvador

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Stockert, Amy L. "Spectroscopic and kinetic studies of bovine xanthine oxidase and Rhodobacter capsulatus xanthine dehydrogenase". Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1089910515.

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Thesis (Ph. D.)--Ohio State University, 2004.
Title from first page of PDF file. Document formatted into pages; contains xv, 172 p.; also includes graphics. Includes bibliographical references (p. 165-172).

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Costa, Eliângela Cristina Cândida. "Estudo químico e avaliação do potencial biológico da raiz de Kielmeyera coriacea Mart. & Zucc (Calophyllaceae)". Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/8595.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Cerrado is a region whose biological richness is unique, being formed by about 10 thousand plants. The flora study, ethnobotanic stands out for understanding of the interaction of society whit plants. In this view, teacher Dr. Vanessa Pasqualotto research group’s has been carrying out ethnobotanic survey in collaboration with the Coqueiros community, with the objective of recovering and valuing the popular knowledge about medicinal plants, among which the Kielmeyera coriacea species, the focus of this study, stands out. In this group, 37 members were interviewed, of which 76% indicate K. coriacea for the treatment of infections, rheumatism, leukemia, tooth pain, among others. Thus, the chemical study of ethanolic extract of roots (EER) of this species, aiming at to characterize its secondary metabolites, since there are no chemical reports in the literature for this part of the plant. In addition antioxidant, antimicrobial and antitumor potential of K. coriacea were evaluated. From the liquid-liquid extraction of EER the hexane (FH), ethyl acetate (FAE) and hydroalcoholic (FHA) fractions were obtained; by the fractionation of FAE, the substance 3-hydroxy-2,4- dimethoxyxanthone was isolated. Additionally, a fingerprint study was performed by LC-MS technique, identifying major compounds such as δ-tocotrienol, prenylated acylphoroglucinol, 2-hydroxy-1-methoxyxanthone, quercitrin. EER, FH, FAE, FHA, its subfractions and the isolated substance were submitted to biological tests. FHA presented antioxidant action with EC50 de 201,53 μg mL-1. EER and FH-10 subfraction from FH fractionation, inhibited the bacterial growth of Streptococcus pyogenes and S. pneumoniae (Minimum Inhibitory Concentration of 6.25 and 1.56 μg mL-1, respectively); EER also inhibited the fungus Candida glabrata in 7.81 μg mL-1. Finally, FH, FAE and FH-10 presented an antitumor effect against the HeLa cells, which are related to cervical cancer (IC50 of 2.5 μg mL-1, 2.5 μg mL-1 and 0.89 μg mL-1, respectively). When correlating the chemical and biological data, it is possible that the FAE-4.7.3 subfractions, from the fractionation of FAE, and FH-10 are constituted by substances such as 4-hydroxy-2,3-methylenedioxy xanthone, 3-hydroxy-1,2-dimethoxy xanthone, lupeol, prenylated acylphoroglucinol and quercitrin, which could be associated with the biological potential found. Therefore, the knowledge acquired in this study contributed to the expansion of the chemical-biological knowledge of K. coriacea.
O Cerrado é uma região cuja riqueza biológica é singular, sendo formado por cerca de 10 mil plantas. No estudo da flora, a etnobotânica se destaca por compreeder a interação da sociedade com as plantas. Nesse contexto, o grupo de pesquisa da Profa. Dra. Vanessa Pasqualotto vem realizando estudos etnobotânicos em colaboração com a comunidade Coqueiros, visando o resgate e a valorização dos saberes populares sobre plantas medicinais, dentre as quais se destaca a espécie Kielmeyera coriacea, foco deste estudo. Neste estudo foram entrevistados 37 membros, em que 76% indicam K. coriacea para o tratamento de infecções, reumatismo, leucemia, dor no dente, dentre outras. Assim, foi realizado o estudo químico do extrato etanólico da raiz (EER) desta espécie, objetivando caracterizar seus metabólitos secundários, uma vez que não há relatos químicos na literatura para esta parte da planta. Ademais, foi avaliado os potenciais antioxidante, antimicrobiano e antitumoral de K. coriacea. A partir da extração líquido-líquido de EER foram obtidas as frações hexano (FH), acetato de etila (FAE) e hidroalcoólica (FHA); pelo fracionamento da FAE foi isolada a substância 3-hidroxi-2,4-dimetoxixantona. O estudo do perfil químico foi realizado por CLAE-EM, identificando-se compostos majoritários como δ-tocotrienol, acilforoglucinol prenilado, 2-hidroxi-1-metoxixantona e quercitrina. EER, FH, FAE, FHA e suas subfrações, bem como a substância isolada foram submetidos aos ensaios biológicos. FHA apresentou ação antioxidante com EC50 de 201,53 μg mL-1. EER e a subfração FH-10, proveniente do fracionamento de FH, inibiram o crescimento bacteriano de Streptococcus pyogenes e S. pneumoniae (Concentração Inibitória Mínima de 6,25 e 1,56 μg mL-1, respectivamente); EER também inibiu o fungo Candida glabrata na 7,81 μg mL-1. Por fim, FH, FAE e FH-10 apresentaram efeito antitumoral frente à célula HeLa, a qual está relacionada ao câncer do cólon do útero (IC50 de 2,5, 2,5 e 0,89 μg mL-1, respectivamente). Ao correlacionar os dados químicos com biológicos, tem-se que as subfrações FAE-4.7.3, proveniente do fracionamento de FAE, e FH-10 são constituídas por substâncias como 4-hidroxi-2,3-metilenodioxixantona, 3-hidroxi-1,2-dimetoxixantona, lupeol, acilforoglucinol prenilado e a quercitrina, as quais poderiam estar associadas ao potencial biológico encontrado. Portanto, o conhecimento adquirido neste estudo contribuiu para a ampliação dos saberes químico-biológicos de K. coriacea.

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Fujisawa(Morita), Yukari. "Identification of xanthine dehydrogenase/xanthine oxidase as a rat Paneth cell zinc-binding protein". Kyoto University, 2001. http://hdl.handle.net/2433/150188.

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Wilson, Wendy Lee. "Xanthine oxidase in the lung". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26669.

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The generation of oxygen free radicals by the cytosolic enzyme, xanthine oxidase (XO), has been implicated in post-ischemic or reperfusion damage in several organs. XO catalyzes the conversion of hypoxanthine to urate with the concomitant production of superoxide anion free radical (0₂̅˙) and hydrogen peroxide (H₂O₂). Oxygen free radical-mediated injury has also been demonstrated in inflammatory lung disease. The possible involvement of XO in oxidative injury in the lung has not yet been studied. Therefore, this research project was designed to determine whether XO is present in the lung and to investigate its characteristics in porcine, bovine, rat and human lung and other tissues. Immunochemical analysis of xanthine oxidase in the tissues employed on polyclonal antibody raised to bovine milk XO. Proteins were separated by SDS-polyacrylamide gel electrophoresis of tissue homogenates. Proteins were transfered from the gels to nitrocellulose filters by Western blotting. After incubating the filters with a antisera containing the antibody to the purified bovine XO. XO on the filter was detected by its reaction with an enzyme-conjugated second antibody. XO was immunologically detectable in bovine lung and milk. Rat lung, kidney and liver all showed XO reactivity. XO was detectable in porcine liver but not detectable in porcine lung or kidney. Thus, the antibody to bovine XO was cross-reactive with porcine and rat XO. XO protein was not immunologically detectable in human lung possibly because the antibody was not cross reactive with the bovine antibody. In vivo, xanthine oxidase exists predominantly as a dehydrogenase rather than an oxidase. In this form as xanthine dehydrogenase (XDH) the enxyme does not produce either 0₂̅˙ or H₂O₂. The activity of both XDH and XO was measured in several tissues using a fluorometric assay which uses an artifical substrate, pterin which is catalytically converted to the fluorescent product isoxanthopterin (IXP). XO activity in porcine liver was of 1.1 x 10⁻³ µg IXP/mg protein/min although XO activity was not detectable in porcine lung and kidney, in rat lung of 1.7 x 10⁻² µg IXP/mg protein/min, rat kidney of 1.5 x 10⁻² µg IXP/mg protein/min, and rat liver of 2.2 x 10⁻² µg IXP/mg protein/min. Seven human lung biopsy samples were obtained after lung resection and initially tested for viability by determination of NADH oxidase activity and then assayed for XO-XDH. Three of these samples showed NADH oxidase activity indicating tissue viability, but only one of these three showed measurable XO activity of 5.35 x 10⁻⁶ µg IXP/mg protein/min. Irreversible conversion of XDH to XO is thought to be the result of limited proteolysis by a Ca²⁺/calmodulin activated protease, whereas reversible conversion of the enzyme occurs by oxidation of critical thiol groups. Studies on the rate and nature of fluorescence assay to detect catalytic activities of both enzyme forms. Incubation of lung homogenates with trypsin for 60 min caused irreverisble conversion of 90% of the XDH to XO. In contrast, incubation of homogenates at 15°C for 10 hours caused conversion of 100% of the XDH to XO. This conversion was reversible to the extent of 80% by reduction of thiol groups with dithiothreitol (DTT). The effects of free Ca²⁺ on the conversion of XDH to X0 was examined by using EDTA, a chelator of Ca²⁺ and other divalent cations; and EGTA, a more specific chelator of Ca²⁺. The presence of these chelating agents during homogenization of either normoxic or ischemic rat lung tissue did not inhibit reversible enzyme conversion. Increased XO activity was reversible by DTT. In the normoxic rat lung, homogenates prepared with EDTA and EGTA showed a similar conversion of 95% of XDH to XO which was reversible to 70% with DTT. In the ischemic rat lung, samples prepared with EDTA and EGTA showed a'conversion of 80% and 95% XDH to XO which was similar to control samples. The extent of reversibility to XDH was 75% with DTT incubation. In addition, perfusion of rat lungs with EDTA and DTT via a pulmonary artery cannula prior to 60 min of ischemia and homogenization did not affect the extent of XDH to XO conversion. These results indicate that irreversible Ca²⁺-mediated proteolytic conversion of XDH to XO does not occur to a great extent in the rat lung during either normoxia or ischemia. However, reversible conversion of XDH to XO does occur, suggesting that reversible thiol dependent conversion may play a role in the lung under both physiological and pathophysiological states.
Medicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate

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Gibson, Elizabeth. "Porphyrin probes for xanthine oxidase". Thesis, University of York, 2007. http://etheses.whiterose.ac.uk/9915/.

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Martin, Hannah M. "Cellular expression of xanthine oxidoreductase". Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426176.

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Wang, Jinfang. "Xanthine-imprinted polymers for decaffeination applications". Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431777.

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Más fuentes

Libros sobre el tema "Xantine"

Karl-Erik, Andersson, Persson C. G. A y AB Draco, eds. Anti-asthma xanthines and adenosine: Proceedings of a symposium in Copenhagen, February 22-23, 1985. Amsterdam: Excerpta Medica, 1985.

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Xanthines and cancer: An experimental study of tumour inhibition. Aberdeen: Aberdeen University Press, 1988.

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Laverdure, Bertrand. Gomme de xanthane: Roman. Montréal: Triptyque, 2005.

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Tiefenbach, Heinrich. Xanten - Essen - Köln. Göttingen: Vandenhoeck & Ruprecht, 1985. http://dx.doi.org/10.13109/9783666203176.

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Xantilamoxtli =: Códice Xantil. Chimalistac [México]: CONACULTA, 2002.

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Holger, Kempkens, ed. St. Viktor zu Xanten. Xanten [Germany]: Propsteigemeinde St. Viktor, 2002.

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Xanten, Landschaftsverband Rheinland Regionmuseum, ed. Das Stift von Xanten. Köln: Rheinland-Verlag, 1986.

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G, Nikolaeva G., Dargaeva T. D y Izyneev A. A, eds. Prirodnye ksantony. Novosibirsk: Izd-vo "Nauka," Sibirskoe otd-nie, 1986.

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Untersuchungen an gesteinsbewohnenden xanthonhaltigen Sippen der Flechtengattung Lecidella (Lecanoraceae, Lecanorales) unter besonderer Berücksichtigung von aussereuropäischen Proben exklusive Amerika. Berlin: J. Cramer, 1990.

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Stefan, Kraus y Rieche Anita 1950-, eds. Xantener Berichte: Grabung, Forschung, Präsentation : Sammelband. Köln: Rheinland-Verlag, 1995.

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Capítulos de libros sobre el tema "Xantine"

Bährle-Rapp, Marina. "Xanthine". En Springer Lexikon Kosmetik und Körperpflege, 595. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_11237.

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Schlimmer, P. y G. W. Sybrecht. "Xanthine". En Pharmakotherapie bronchopulmonaler Erkrankungen, 53–66. Vienna: Springer Vienna, 2000. http://dx.doi.org/10.1007/978-3-7091-6761-8_5.

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Kobayashi, Kensei. "Xanthine". En Encyclopedia of Astrobiology, 1–2. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-642-27833-4_5352-1.

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Harrison, Roger. "Xanthine oxidoreductase". En Free Radicals and Inflammation, 65–81. Basel: Birkhäuser Basel, 2000. http://dx.doi.org/10.1007/978-3-0348-8482-2_6.

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Schomburg, Dietmar y Dörte Stephan. "Xanthine oxidase". En Enzyme Handbook 10, 447–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57756-7_118.

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Schomburg, Dietmar y Dörte Stephan. "Xanthine dehydrogenase". En Enzyme Handbook 10, 184–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-57756-7_52.

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Schomburg, Dietmar y Dörte Stephan. "Xanthine phosphoribosyltransferase". En Enzyme Handbook 12, 1049–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61117-9_227.

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Kinuta, Y., H. Kikuchi y M. Ishikawa. "Ischaemic Brain Oedema and Xanthine-Xanthine Oxidase System". En Brain Edema VIII, 192–94. Vienna: Springer Vienna, 1990. http://dx.doi.org/10.1007/978-3-7091-9115-6_65.

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Haubeck, H. D. "Xanthin". En Springer Reference Medizin, 2517. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3332.

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Haubeck, H. D. "Xanthin". En Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49054-9_3332-1.

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Actas de conferencias sobre el tema "Xantine"

Li, Li, Ke-li Chen, Jia-cheng Xu y Xiang Lei. "Inhibition Action on Xantine Oxidase by Biflavonoids from Selaginella labordei". En 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE 2009). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5162968.

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Ozgocmen, S., O. Ardicoglu, S. Sogut, I. Pekkutucu, E. Fadillioglu y O. Akyol. "SAT0020 Serum nitric oxide, catalase, superoxide dismutase, xantine oxidase and malandialdehyde status in patients with ankylosing spondylitis". En Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.372.

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Bentivenga, C., ER Cosentino, F. Ventura, G. Magri, I. Ricci Iamino, S. Bacchelli, E. Ambrosioni et al. "THU0420 Improved survival of post-myocardial infarction patients treated with zofenopril combined with xantine oxidase inhibitors as compared to placebo or other ace-i". En Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5012.

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Shatos, M., J. Doherty, D. Allen y J. Hoak. "ALTERATIONS IN VASCULAR ENDOTHELIAL CELL FUNCTION BY OXYGEN-FREE RADICALS". En XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643365.

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The vascular endothelium is a target for oxidant-induced damage in many disease states including hyperoxia, inflammation, ischemia and reperfusion injury. However, little is known concerning oxidant injury to endothelial cells and its relationship to hemostasis. Our studies have focused on the ability of oxygen free radicals to injure and/or alter selected vascular endothelial cell functions pertinent to the regulation of hemostasis. Xanthine and xanthine oxidase, a well-characterized generating system for the production of the superoxide anion radical (O− 2) was used to sublethally injure human umbilical vein endothelial cells (HUVE) in vitro. We examined the effects of a 15 min exposure of HUVE cells to xanthine (50μM), and xanthine oxidase (2.5-100mU) (previously determined to be non-toxic using trypan blue dye exclusion) on platelet adherence, and prostacyclin release using established assays. The antioxidant enzymes superoxide dismutase (SOD) 200μg/ml and catalase 50μg/ml were added to endothelium incubation systems to evaluate any protective effects upon O− 2-induced alterations. All experiments were conducted in a serum-free HEPES-Tyrode's buffer, pH 7.4 incubation system. Our results show that exposure of HUVE cells to sublethal concentrations of oxygen free radical generating systems causes significant enhancement of platelet adherence (65%) to injured endothelium. A 12-fold increase in prostacyclin release resulted after a 15 min treatment with xanthine and xanthine oxidase. The addition of exogenous PGI2 (150nM) to platelet-endothelial systems did not completely prevent the enhanced platelet adherence suggesting that lack of prostacyclin was not completely responsible for the adherence of platelets to O− 2 injured cells. When SOD and catalase, scavengers of O− 2 and H2O− 2, were added to treated cells, platelet adherence decreased by 42-77% and prostacyclin release approached that of control cultures. These data implicate an active participation of activated metabolites of molecular oxygen in the alteration of vascular endothelial cell function.

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Zahavi, J., R. Schafer, A. Zelikos-ki, E. Firsteter, M. Zahavi y E. Avrahami. "EFFICACY OF INTRAVENOUS PENTOXIFYLLINE IN THE MANAGEMENT OF PATIENTS WITH CRITICAL LEG ISCHEMIA". En XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644824.

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The xantine derivative pentoxifylline (P) can promote blood flow in the macro-and-micro circulation of ischemic tissues by improvement of red cell rigidity and by enhancing PGI2 release from the vascular endothelium. 35 patients (mean age 71±1.2 1SE years) suffering from critical leg ischemia due to advanced peripheral vascular disease (PVD) were treated by continuous I.V. drip of P (mean dose 22.2 g. during a mean period of 22.2 days). 19 patients were diabetics and 16 non-diabetics. Severity of PVD was assessed by the walking distance (WD), the presence of ischemic rest pain (IRP), leg ulcers or gangrene (doccumented photographically), hemodynamic evaluation using Doppler auscultation andby an arteriography of the lower limbs. The most common lesion on arteriography was occlusion or severe stenosis of the superficial femoral artery. All the patients suffered from IRP, 20 of them from leg ulcers and or gangrene. Following treatment of the diabetics, the WD was considerably improved (p≺0.01) in 7patients, the IRP disappeared in 11 and was milder in another 4 patients. Leg ulcers were healed in 5.out of 11 patients and gangrene subsided in 2 out of 9 patients. It was partially healed in another3 patients. Thus only in 4 patients the leg ischemia was worse and required bellow-knee amputation. In the non-diabetics, WD was improved considerably in 12 patients, the IRP disappeared in 11 and was milder in another 4 ' patients. Gangrene subsided in 2 out of 4 patients andwasimproved in the remaining 2 patients. None of these patients underwent amputation. The resting ankle pressure index(on Doppler auscultation) values were similar in the 2 groups and were increased after treatment (p≺0.01).Our results indicate that P ia a useful drug in the management of patients with advanced PVD and critical leg ischemia particularly in non-diabetics. It should be considered in inoperable patients in whom leg amputation is imminent. P can induce both subjective and objective improvement in the WD and the hemodynamicprofile of these patients and promote the blood flow in the microcicul-ation of the ischemic tissues in the lower limbs.

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Rita Meyer Ferraz da Costa, Maria. "AVALIAÇÃO DO PROCESSO DE SÍNTESE DE GOMA XANTANA A PARTIR DE MATÉRIA-PRIMA RESIDUAL PARA APLICAÇÕES AVANÇADAS". En Congresso Brasileiro de Inovação em Microbiologia. Congresse.me, 2022. http://dx.doi.org/10.54265/zkwe8618.

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A goma xantana é um heteropolissacarídeo produzido por bactérias do gênero Xanthomonas e é utilizada em diversos processos industriais. É o polímero mais utilizado para aplicações alimentícias como espessante, estabilizante e emulsificante. A xantana possui características reológicas que mantêm sua alta viscosidade em baixas concentrações e a tornam muito atrativas. O objetivo deste trabalho foi avaliar o processo de síntese da goma xantana por meio da bactéria Xanthomonas campestris CCT 5268 a partir de sacarose, bagaço e caldo de cana como fonte de carbono. Para a produção de goma xantana, 3 diferentes meios de fermentação foram preparados utilizando substratos alternativos. Os meios 1 e 2 foram compostos por uma extração a frio (moagem e filtragem) do bagaço de cana (6% m/v). Além, o meio 2 possuiu uma suplementação de (3% v/v) de caldo. O meio 3 foi composto por sacarose (2% m/v). Para o estudo do processo fermentativo foram coletadas amostras durante 9 dias. A produção de xantana, o crescimento da bactéria por DO e o consumo do substrato pelo método DNS foram analisados. O tempo padrão de fermentação é de 120 h, porém a bactéria ainda se encontrava em estado estacionário mesmo após este tempo, o que contribuiu para a produção de goma xantana. O crescimento bacteriano mostrou que não houve consumo significativo da bactéria pela sacarose, o que corrobora uma longa fase de adaptação ao meio. A concentração de açúcares diminui significativamente ao longo dos dias para substratos contendo cana-de-açúcar, o que confirma a adaptação do substrato para o crescimento das bactérias e produção do biopolímero. O meio 2 foi o substrato que obteve maior rendimento de goma xantana, 5,24 g/L, o meio 1, 3,07 g/L, enquanto o meio 3, 0,35 g/L. Os resultados indicaram que o meio de sacarose requer maior tempo de adaptação. Os substratos naturais contendo cana-de-açúcar apresentaram rápida adaptação e produção satisfatória de goma xantana após o tempo padrão de fermentação devido à maior concentração de açúcar presente no meio. Palavras-chave: biopolímero; cana-de-açúcar; goma xantana; meios alternativos.

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Vanegas, D. C., C. Gomes y E. S. McLamore. "Xanthine oxidase biosensor for monitoring meat spoilage". En SPIE Sensing Technology + Applications, editado por Brian M. Cullum y Eric S. McLamore. SPIE, 2014. http://dx.doi.org/10.1117/12.2050489.

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Royhoudhury, Sohini, Apoorva Shah, Ishaan Shah, Yogeswaran Umasankar y Shekhar Bhansali. "Nano-Composite Enzymatic Xanthine Biosensor for Wound Diagnostics". En 2018 IEEE Sensors. IEEE, 2018. http://dx.doi.org/10.1109/icsens.2018.8589952.

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Andrade, Luan Alberto, Cleiton Antônio Nunes y Joelma Pereira. "CARACTERÍSTICAS QUÍMICAS DA GOMA XANTANA COMERCIAL". En I Congresso Brasileiro de Biotecnologia On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2021. http://dx.doi.org/10.51189/rema/792.

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Introdução: A goma xantana é um polissacarídeo sintetizado por uma bactéria fitopatogênica do gênero Xanthomonas e tem extrema importância comercial. É um produto utilizado na área de alimentos como aditivo e classificado como agente emulsificante, espessante e estabilizante Objetivo: Conhecer algumas características químicas da goma xantana comercial. Material e métodos: Para leitura do potencial hidrogeniônico utilizou-se um potenciômetro digital. Inicialmente preparou-se uma suspensão da goma em 100 mL de água destilada, com agitação por 10 minutos e, assim, realizou-se a leitura do pH. Posteriormente, a mesma suspensão utilizada anteriormente, foi agitada, enquanto se adicionou uma solução de NaOH 0,1 mol L-1 até atingir pH próximo a 8 para calcular o teor de acidez, expresso em miliequivalente de NaOH por 100 g da matéria integral. Os açúcares foram determinados pelo método redutométrico. Utilizou-se um espectrofotômetro para leitura das absorbâncias com comprimento de onda igual a 510 nm. Todas as análises foram realizadas com três repetições. Resultados: O pH e a quantidade de acidez titulável foi de 6,21 e 5,45 respectivamente. Conhecer o pH é de fundamental importância para os alimentos/aditivos, pois pode ser utilizado como medida de controle de qualidade. Produtos mais ácidos são naturalmente mais estáveis quanto à deterioração, pois bactérias preferem pH mais alto para se proliferarem. Os teores de açúcares redutores, não redutores e totais foram de 0,09%, 0,12% e 0,21% respectivamente. Os baixos valores encontrados na quantificação de açúcares na goma xantana sinalizam que os carboidratos presentes em solução estão, principalmente, na forma de polissacarídeos, como consta na literatura. Conclusão: A goma xantana, um produto obtido da biotecnologia, forma solução levemente ácida, possui ácidos orgânicos devido ao teor de acidez titulável e contém baixos teores de açúcares simples, sendo formada por carboidratos complexos.

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Tran, H., NN Le, AT Trinh y TN Huynh. "Xanthine oxidase inhibitory activities of some Vietnamese medicinal plants". En 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400114.

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Informes sobre el tema "Xantine"

Bedina, S. A., E. E. Mozgovaia, E. A. Tikhomirova, M. A. Mamus, S. S. Dotsenko y A. S. Trofimenko. Xanthine oxidase and xanthine dehydrogenase activity in rheumatoid arthritis: the enzyme profile of blood plasma. ООО "ИМА-Пресс", 2018. http://dx.doi.org/10.18411/1995-4484-2018-56-33-8.

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Bedina, S. A., E. E. Mozgovaya, I. A. Zborovskaya, A. S. Trofimenko y E. G. Korenskaya. ENZYMATIC PROFILE OF BLOOD PLASMA IN RHEUMATOID ARTHRITIS: ACTIVITY OF XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxv-54-61.

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Bedina, S. A., E. E. Mozgovaya, A. S. Trofimenko, S. S. Spitsina, M. A. Mamus y E. A. Tikhomirova. ENZYMATIC PROFILE OF BLOOD PLASMA IN SYSTEMIC SCLEROSIS: ACTIVITY OF XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-38-45.

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Bedina, S. A., E. E. Mozgovaya, A. S. Trofimenko, N. M. Devyataeva, M. A. Mamus, S. S. Spitsyna y E. A. Tikhomirova. XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE ACTIVITIES OF BLOOD PLASMA DEPENDING ON CLINICAL FEATURES OF SYSTEMIC SCLEROSIS. Academy of Natural Knowledge, 2019. http://dx.doi.org/10.18411/1996-3955-2019-10-268-272.

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Hodson, R. Analyzing Xanthine Dehydrogenase Iron-Sulfur Clusters Using Electron Paramagnetic Resonance Spectroscopy. Office of Scientific and Technical Information (OSTI), febrero de 2004. http://dx.doi.org/10.2172/826721.

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Mozgovaia, E. E., S. A. Bedina, A. S. Trofimenko y I. A. Zborovskaia. Features of changes in the activity of xanthine oxidase and xanthine dehydrogenase in lymphocyte lysates and blood plasma in rheumatoid arthritis with the use of glucocorticoids. ООО ИМА-Пресс, 2018. http://dx.doi.org/10.18411/1995-4484-2018-56-3(2)-55-56.

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Bedina, S. A., E. E. Mozgovaia, A. S. Trofimenko y I. A. Zborovskaia. The activity of enzymes of the xanthine oxidase / xanthine dehydrogenase complex in blood plasma and lymphocyte lysates in patients with seropositive and seronegative forms of rheumatoid arthritis. Академия Естествознания, 2018. http://dx.doi.org/10.18411/1996-3955-2018-6-61-64.

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Munhenzva, Ian. Optimized Xanthene-based Probes for Pancreatic Cancer Imaging. Portland State University Library, mayo de 2020. http://dx.doi.org/10.15760/etd.7333.

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Mozgovaya, E. E., S. A. Bedina, A. S. Trofimenko, M. A. Mamus, S. S. Spitsina y I. A. Zborovskaya. XANTHINE OXIDOREDUCTASE ACTIVITY IN BLOOD DEPENDING ON THE FUNCTIONAL CLASS OF RHEUMATOID ARTHRITIS PATIENTS. DOI CODE, 2021. http://dx.doi.org/10.18411/wco-iof-esceo-2021-428-429.

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Mozgovaya, E. E., S. A. Bedina, I. A. Zborovskaya, A. S. Trofimenko, M. A. Mamus, E. A. Tikhomirova y S. S. Spitsina. XANTHINE OXIDOREDUCTASE AND SUPEROXIDE DISMUTASE ACTIVITIES OF BLOOD PLASMA DEPENDING ON TYPE OF SYSTEMIC SCLEROSIS. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-120-127.

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