Literatura académica sobre el tema "Wu dao yin lue"

This paper aims to unravel the underlying resonance between the Daoist Way and the Deleuzian idea of an aleatory point. The Daoist Way is explicated as the zhong dao 中道 or the Middle-Way, viewed in terms of interactivity between such Daoist-seeming polarities as you/wu (determinate/indeterminate) and Yin and Yang. The first part of the paper approaches the Daoist Way in terms of the concept of zhong 中 or the “Middle”, to explore the functionality of the Way and to comprehend the Chinese philosophical concept of the Middle, using the Deleuzian lens of the “aleatory point”. The “Middle” here is understood as process, change, or flux, whose volatility is not representational or repeatable. It is this irrepresentability that renders the concept of the “Middle” comparable with the Deleuzian notion of aleatory point. The second part of the paper probes the most fundamental paradoxes revolving around the Daoist Middle-Way to unveil the relationship between the Way and Chaos and to deconstruct the traditional misconception of Yin/Yang dynamics as unity.

BackgroundIxekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, has demonstrated efficacy in global clinical trials in patients with active radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS)[1,2].Rapid onset of clinical improvement is one of the most important needs of treatment for r-axSpA patients.ObjectivesTo evaluate the onset time of ixekizumab in Chinese patients with r-axSpA.MethodsThis report evaluated efficacy onset time of r-axSpA patients treated with ixekizumab compared with placebo based on data from a phase 3 study in China.The major secondary efficacy measures in this report included Assessment of Spondyloarthritis International Society (ASAS) 40 response, ASAS 20 response, change from baseline in Ankylosing Spondylitis Disease Activity Score (ASDAS), change from baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), change from baseline in Bath Ankylosing Spondylitis Functional Index (BASFI), and ASDAS <2.1 response.Other secondary efficacy measures in this report included change from baseline of ASAS individual components (like patient global, Spinal pain, Inflammation, high sensitivity C-reactive protein [hsCRP]), proportion of patients who experience clinically important improvement (change of ASDAS from baseline ≥1.1), major improvement (change of ASDAS from baseline ≥2.0), and BASDAI 50 response. All efficacy measures were evaluated from week 0 through week 52.A logistic regression model and mixed-effects model of repeated measures (MMRM) were used to analyze categorical and continuous measures from week 0 to 16 (placebo-controlled period), and categorical missing data were imputed using non-responder imputation (NRI).ResultsMore patients achieved ASAS40 and ASAS20 response as early as week 1 (p = 0.042 and p < 0.001) in the ixekizumab-treated group compared with placebo.In addition, statistically significant (p < 0.05) improvements were observed as early as week 1 for the ixekizumab group compared to placebo in almost all efficacy measures mentioned above.For other outcomes including proportion of patients who experience major improvement and BASDAI 50 response, differences were evident (p < 0.05) by week 2 in the ixekizumab group compared with placebo.Furthermore, ixekizumab sustained high efficacy in all efficacy measures through 52 weeks.ConclusionIxekizumab demonstrated a rapid onset of efficacy improvements on ASAS response, ASAS core set values, disease activity and function in Chinese patients with r-axSpA.References[1]Désirée van der Heijde, James Cheng-Chung Wei, Maxime Dougados, et al. Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial.Lancet2018; 392: 2441–51.[2]Deodhar A, Poddubnyy D, Pacheco-Tena C, et al. Efficacy and safety of ixekizumab in the treatment of radiographic axial spondyloarthritis: sixteen-week results from a phase III randomized, double-blind, placebo-controlled trial in patients with prior inadequate response to or intolerance of tumor necrosis factor inhibitors.Arthritis Rheumatol2019; 71:599–611.AcknowledgementsThe author would like to thank Zipei Xiao for medical assistance and Fei Ji for peer review (both of Eli Lilly and Company employees), and all study participants.Disclosure of InterestsYU XUE Consultant of: Yu Xue has been investigator of Eli Lilly and Company, Jiankang Hu Consultant of: Jiankang Hu has been investigator of Eli Lilly and Company, Dongzhou Liu Consultant of: DongZhou Liu has been investigator of Eli Lilly and Company, Jingyang Li Consultant of: Jingyang Li has been investigator of Eli Lilly and Company, Huaxiang Wu Consultant of: Huaxiang Wu has been investigator of Eli Lilly and Company, Chunyu Tan Consultant of: Chunyu Tan has been investigator of Eli Lilly and Company, Lie Dai Consultant of: Lie Dai has been investigator of Eli Lilly and Company, Yan Yan Employee of: Yan Yan is employee of Eli Lilly and Company, Hongying Li Shareholder of: HongYing Li is minor stockholder of Eli lilly and Company, Employee of: HongYing Li is employee of Eli Lilly and Company, Hejian Zou Consultant of: Hejian Zou has been investigator of Eli Lilly and Company.

Abstract Downsizing metal nanoparticle catalysts to form single-atom catalysts (SACs) has proven to be one of the best ways to enhance the catalysts’ activity and selectivity1-2 due to their unique characteristics such as nearly 100% atom utilization and well-defined active sites.3 However, the broad application of SACs in catalytic reactions is limited by their poor stability as they possess high surface energy and thus tend to aggregate and form nanoclusters or nanoparticles.4 To address this challenge, various supports such as metal oxides, carbon materials, and porous materials are widely used to stabilize the SACs.5 Metal organic frameworks (MOFs), a class of porous crystalline materials, have proven to be an ideal candidate to support SACs owing to their high surface area, high porosity, and abundant potential anchoring sites.6 It has been shown that immobilizing SACs on MOFs, which forms MOF supported SACs, can integrate the unique properties of SACs and MOFs and led to remarkable catalytic activity, selectivity, and stability toward various catalytic reactions.6-8 Application of MOF supported SACs in photocatalysis, organic linkers of metal-organic frameworks act as photosensitive units,9 However most pristine metal-organic frameworks possesses poor light absorption properties due to wide band gap.9To enhance the light harvesting properties of the metal organic framework its organic linker is functionalized.10-11 In my poster presentation, I will present my work where post-synthetic modification of UiO-66-NH2 MOF linker with 3,4,9,10 perylene tetracarboxylic dianhydride (PDA) an organic molecule with broad absorption edge,12and immobilization of Ni single atom catalyst on the zirconium cluster of the MOF was done. This resulted in enhanced optical properties and charge separation efficiency which was proved by a combination of UV-visible spectroscopy (UV-Vis), photoelectrochemical techniques, and X-ray absorption spectroscopy (XAS). Observed photophysical effects posed by the modifications of the UiO-66-NH2 were evaluated by photocatalytic hydrogen generation. References Yan, J.; Kong, L.; Ji, Y.; White, J.; Li, Y.; Zhang, J.; An, P.; Liu, S.; Lee, S.-T.; Ma, T., Single atom tungsten doped ultrathin α-Ni (OH) 2 for enhanced electrocatalytic water oxidation. Nature communications 2019, 10 (1), 1-10. Jiao, L.; Jiang, H.-L., Metal-organic-framework-based single-atom catalysts for energy applications. Chem 2019, 5 (4), 786-804. Qiao, B.; Wang, A.; Yang, X.; Allard, L. F.; Jiang, Z.; Cui, Y.; Liu, J.; Li, J.; Zhang, T., Single-atom catalysis of CO oxidation using Pt1/FeO x. Nature chemistry 2011, 3 (8), 634-641. Xia, C.; Qiu, Y.; Xia, Y.; Zhu, P.; King, G.; Zhang, X.; Wu, Z.; Kim, J. Y.; Cullen, D. A.; Zheng, D., General synthesis of single-atom catalysts with high metal loading using graphene quantum dots. Nature chemistry 2021, 13 (9), 887-894. Wu, J.; Xiong, L.; Zhao, B.; Liu, M.; Huang, L., Densely populated single atom catalysts. Small Methods 2020, 4 (2), 1900540. Huang, H.; Shen, K.; Chen, F.; Li, Y., Metal–organic frameworks as a good platform for the fabrication of single-atom catalysts. ACS Catalysis 2020, 10 (12), 6579-6586. Qu, W.; Chen, C.; Tang, Z.; Wen, H.; Hu, L.; Xia, D.; Tian, S.; Zhao, H.; He, C.; Shu, D., Progress in metal-organic-framework-based single-atom catalysts for environmental remediation. Coordination Chemistry Reviews 2023, 474, 214855. Szilágyi, P.; Rogers, D.; Zaiser, I.; Callini, E.; Turner, S.; Borgschulte, A.; Züttel, A.; Geerlings, H.; Hirscher, M.; Dam, B., Functionalised metal–organic frameworks: a novel approach to stabilising single metal atoms. Journal of Materials Chemistry A 2017, 5 (30), 15559-15566. He, J.; Wang, J.; Chen, Y.; Zhang, J.; Duan, D.; Wang, Y.; Yan, Z., A dye-sensitized Pt@ UiO-66 (Zr) metal–organic framework for visible-light photocatalytic hydrogen production. Chemical communications 2014, 50 (53), 7063-7066. Elcheikh Mahmoud, M.; Audi, H.; Assoud, A.; Ghaddar, T. H.; Hmadeh, M., Metal–Organic Framework Photocatalyst Incorporating Bis(4′-(4-carboxyphenyl)-terpyridine)ruthenium(II) for Visible-Light-Driven Carbon Dioxide Reduction. Journal of the American Chemical Society 2019, 141 (17), 7115-7121. Hendrickx, K.; Joos, J. J.; De Vos, A.; Poelman, D.; Smet, P. F.; Van Speybroeck, V.; Van Der Voort, P.; Lejaeghere, K., Exploring lanthanide doping in UiO-66: a combined experimental and computational study of the electronic structure. Inorganic Chemistry 2018, 57 (9), 5463-5474. Yu, H.; Joo, P.; Lee, D.; Kim, B. S.; Oh, J. H., Photoinduced Charge‐Carrier Dynamics of Phototransistors Based on Perylene Diimide/Reduced Graphene Oxide Core/Shell p–n Junction Nanowires. Advanced Optical Materials 2015, 3 (2), 241-247.

Abstract Background: The landscape of immunotherapy, employing recombinant cytokines like interleukin-2 (IL-2), confronts challenges marked by its short half-life, systemic toxicity, and constrained tumor accumulation. These hurdles are particularly evident in the context of the immunosuppressive milieu characterizing pancreatic ductal adenocarcinoma (PDAC). Chemo-immuno-therapeutic synergies, notably those provoking immunogenic cell death (ICD), have demonstrated superior efficacy. This investigation delves into Pt-NHC as a type II ICD inducer to surmount immunosuppression and amplify antitumor immunity within a highly tumor-accumulated liposomal drug delivery system. Additionally, the co-administration of the angiotensin receptor blocker, losartan, mitigates desmoplasia in PDAC, further augmenting the efficacy of immunotherapy. Methods: To address the constraints of IL-2, a lipid-coated nanogel, IL2-Pt@Nanogel, was innovated, amalgamating silk fibroin-loaded IL-2 with Pt-NHC. The nanogel aimed to enhance IL-2 pharmacokinetics and optimize tumor targeting. Concurrently, losartan was employed to alleviate desmoplasia within the tumor microenvironment. Result: The chemoimmunotherapy nanogel, when coupled with losartan, showcased therapeutic potential in murine models of desmoplastic PDAC. Pt-NHC induced ER-localized reactive oxygen species (ROS) and DAMP release, reshaping the immunosuppressive microenvironment by repolarizing M2-type macrophages to M1 and diminishing the regulatory T-cell population. Co-delivery of IL-2 and Pt-NHC in the nanogel enhanced T-cell infiltration and activation, curbing tumor progression in primary and liver metastasized PDAC models. Importantly, the addition of losartan reduced collagen accumulation within tumors, resulting in heightened infiltration of effector T cells and more pronounced suppression of tumor growth in PDAC and metastasized liver. Conclusion: This study introduces an innovative nanogel delivery system (IL2-Pt@Nanogel) for chemoimmunotherapy, effectively addressing the challenges associated with IL-2 therapy. Leveraging the enhanced permeability and retention (EPR) effect, the nanogel improves IL-2 stability and tumor delivery. Pt-NHC incorporation induces ICD, reshaping the tumor microenvironment, and in synergy with losartan, elicits robust anticancer immunity. This strategy holds promise for clinical translation as a secure and efficient treatment for immunosuppressive and desmoplastic cancers, such as PDAC, presenting a distinctive therapeutic avenue. Citation Format: Hsuan Yu Mu, Yen-Nhi Ngoc Ta, Jing Rui Max Tham, Fu-Fei Hsu, Yu-Chieh Lin, Hsi-Chien Huang, Yun-Chieh Sung, Chih-I Huang, Ching-Ling Wu, Chao-Hung Chang, Sheng Yang, Tsung-Ying Lee, Jane Wang, Dan G. Duda, Yves Boucher, Jen-Huang Huang, Wee Han Ang, Yunching Chen. Enhancing cancer treatment Via a nanostructured chemoimmunotherapy gel facilitating interleukin-2 delivery and immunogenic cell death induction [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5737.

The vanadium redox flow battery (VRFB) is one of the most promising energy storage technologies for large scale commercialization. Carbon based electrodes, such as carbon felts or carbon paper, are used for V(II/III) and V(IV/V) reactions. To improve the vanadium redox reaction kinetics, the carbon electrodes are usually activated by a variety of methods such as thermal treatment, heteroatom doping, catalyst incorporation etc. [1] It is generally considered that surface functional group such as C–OH, C=O play an important role in vanadium redox reaction [1-6]. Even though there are reports showing higher surface functional group content e.g. total C–O content leads to improved vanadium redox reaction kinetics [2-6], qualitative correlation of the surface property of the carbon materials and the vanadium redox reaction is not reported. There is a need for fundamental understanding of the surface properties of the carbon electrodes and their relation with the reaction kinetics, including the key parameters that determine them. In this work, using cyclic voltammetry (CV), we studied the surface properties of a variety of carbon based electrodes (glassy carbon (GC), edge plane pyrolytic graphite, base plane pyrolitic graphite, graphite (from Pine Research, called graphite-Pine thereafter), graphite rod, and H2SO4 soaked graphite rod), and the V(II/III) and V(IV/V) reaction kinetics on these electrodes. The goal of soaking the graphite rod electrode in H2SO4 is to activate the electrode and make it comparable to the carbon felt electrode [1]. XPS was also used to analyze the functional group. The relationship between the surface properties and the reaction kinetic parameters was analyzed. Fig. 1 compares the cyclic voltammograms (CV) of the edge plane, basal plane graphite and GC electrodes in 2 M H2SO4. Two redox couples are observed, ascribed to C=O and COOH group redox peak respectively [7]. On basal plane electrode, these two redox peaks are less significant, and an extra reduction peak is observed at 0.24 V due to the C–OH reduction. On the GC electrode, the C=O redox peak is still discernable but the COOH redox peak is almost undetectable. A capacitance region appears between 0.6 – 0.75 V vs Ag/AgCl for all these electrodes. Similar features are observed with the graphite-Pine, graphite rod and H2SO4 soaked graphite rod electrodes with significantly enhanced redox peaks and larger capacitance. The H2SO4 soaked graphite rod electrode presents the highest surface functional group density and capacitance. XPS also shows that the H2SO4 soaked graphite rod electrode has the highest total C–O content. CV of V(IV/V) and V(II/III) were measured using these electrodes at different scan rates. Fig. 2 shows the CV of V(IV/V) reaction on these electrodes. The three graphite rod electrodes show better reversible feature than the edge plane, basal plane and GC electrodes. Diffusion coefficient, transfer coefficient and reaction rate constant were obtained from the CVs. The diffusion coefficient follows the sequence of soaked graphite rod > graphite rod > Graphite-Pine > Edge plane > GC > basal plane electrode. The transfer coefficient and reaction rate constant are also different for these electrodes. Similarly, the diffusion coefficient, transfer coefficient and reaction rate constant are obtained for the V(II/III) reaction. The diffusion coefficient and reaction rate constant for the V(II/III) reaction are smaller than that for the V(IV/V) reaction on the corresponding electrodes. For both V(IV/V) and V(II/III), a linear relationship was found for diffusion coefficient versus the logarithm of capacitance and C=O group functional group. Higher value of log(capacitance) and log(C=O density) leads to larger diffusion coefficient. However, there is no clear relationship between transfer coefficient, reaction rate constant vs capacitance or C=O density. It seems that the capacitance and C=O functional group density are the importance parameters determining the vanadium redox reaction kinetics. References He, Y. Lv, T. Zhang, Y. Zhu, L. Dai, S. Yao., W. Zhu, L. Wang, Chem. Eng. J., 427 (2022) 131680 Zhang, J. Xia, Z. Li, H. Zhou, L. Liu, Z. Wu, X. Qiu, Electrochim. Acta 89 (2013) 429– 435 Liu, L. Yang, Q. Xu, C. Yan, RSC Adv., 2014, 4, 55666 Choi, H. Noh, S. Kim, R. Kim, R. Kim, J. Lee, J. Heo, H.-T. Kim, J. Energy Storage, 21 (2019) 321 – 327 Eifert, R. Banerjee, Z. Jusys, R. Zeis, J. Electrochem. Soc., 165 (2018) A2577 – A2586 Leuna, D. Priyadarshani, A. K. Tripathi, M. Neergat, J. Electroanal. Chem., 878 (2020) 114590 K. Singh, M. Pahlevaninezhad, N. Yasri, E. P. L. Roberts, ChemSusChem 2021, 14, 2100–2111 Figure 1

Parents play an important role in the development of their children. This research reflects the role of parents in developing children. Through four stages of identification, screening, eligibility, and acceptable results, this method uses a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The findings from the fourteen articles examined show that parenting skills play an important role in a child's growth and development from birth to death. The determining factor in the development of physical, motoric, moral, language, social-emotional, and life skills aspects is the role of both parents as important teachers for children from birth to adulthood. Parents can also use a variety of parenting strategies and skills, many of which they have learned throughout their lives and passed on to their children, to help their children grow. 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Based on Lee’s prior research on Daoism (Lee, 2003; Lee, 2004; Lee, Han, Byron and Fan, 2008; Lee and Hu, 1993; Lee, Norasakkunkit, Liu, Zhang and Zhou, 2008), this article first introduces Laozi, Dao, De and Daoism in relation to harmony. Then, Daoist harmony is elaborated in the following areas: (1) the yin-yang oneness, (2) the way it is (natural), (3) wei-wu-wei (or nonintervention), (4) water-like characteristics, (5) love for peace, and (6) tolerance and appreciation of differences. The article concludes with a suggestion for harmony with the external world as well as with fellow human beings.

Diabetes Mellitus has been becoming a disease of the century, and disease incidence is still rising worldwide. It causes many serious complications, especially in the eye, heart, kidneys, brain, and vascular system, such as diabetic nephropathy, diabetic retinopathy, liver fa­ilure, etc. Moreover, the process of controlling this disease is complicated. Meanwhile, the antidiabetic drugs on the market are facing some problems with a wide range of adverse reactions. Therefore, finding new drugs to treat diabetes has always been a topic that many researchers are interested in, especially drugs derived from nature like microorganisms and medicinal plants. This review is to provide knowledge concerning the effects of α-glucosidase inhibitors, which are oral antidiabetic drugs commonly used for diabetes mellitus type 2. 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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus , is causing a serious worldwide COVID-19 pandemic. The emergence of strains with rapid spread and unpredictable changes is the cause of the increase in morbidity and mortality rates. A number of drugs as well as vaccines are currently being used to relieve symptoms, prevent and treat the disease caused by this virus. However, the number of approved drugs is still very limited due to their effectiveness and side effects. In such a situation, medicinal plants and bioactive compounds are considered a highly valuable source in the development of new antiviral drugs against SARS-CoV-2. This review summarizes medicinal plants and bioactive compounds that have been shown to act on molecular targets involved in the infection and replication of SARS-CoV-2. Keywords: Medicinal plants, bioactive compounds, antivirus, SARS-CoV-2, COVID-19 References [1] R. Lu, X. Zhao, J. Li, P. Niu, B. Yang, H. 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