Tesis sobre el tema "Vitamin E – Therapeutic use"
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Potter, Kathleen. "The effects of long-term homocysteine-lowering treatment with folic acid, vitamin B6 and Vitamin B12 on vascular structure and function in stroke". University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0020.
Texto completoStoll, Karin Elisabeth. "Nutrient supplementation and secondary metaolites in melanoma cells". Thesis, Rhodes University, 1994. http://hdl.handle.net/10962/d1004110.
Texto completoClarke, Michael William. "Vitamin E metabolism in humans". University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0191.
Texto completoFinch, Sarah L. "Postnatal vitamin D supplementation normalizes neonatal bone mass following maternal dietary vitamin D deficiency in the guinea pig". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100246.
Texto completoWu, Tianshu y 吴添舒. "A systematic review of vitamin D for prevention of acute lower respiratory infection among children". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193827.
Texto completopublished_or_final_version
Public Health
Master
Master of Public Health
Halliwell, Celeste y University of Lethbridge Faculty of Arts and Science. "Dietary choline and vitamin/mineral supplement for recovery from early cortical injury". Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/222.
Texto completoxiv, 191 leaves : ill. ; 28 cm.
Hautea, Rhea P. "Vitamin D- induced down regulation of RAD51 in head and neck squamous cell carcinoma (HNSCC), In Vitro and In Vivo". Scholarly Commons, 2011. https://scholarlycommons.pacific.edu/uop_etds/786.
Texto completoMilliken, Erin L. "USE OF A TRANSGENIC MOUSE MODEL OF OVARIAN HYPERSTIUMLUATION TO IDENTIFY THERAPEUTIC TARGETS AND MECHANISMS IN HORMONE-INDUCED MAMMARY CANCER". Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1121273034.
Texto completoMurphy, Stephanie A. "Effects of selenium and vitamin B-6 on growth of chemically- induced transplanted tumors in BALB/c inbred mice". Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/43906.
Texto completoMaster of Science
Mwanri, Lillian. "Impact of vitamin A and iron on anaemia and cognitive functioning of anaemic school children in Tanzania". Title page, table of contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phm994.pdf.
Texto completoAustin, Nicole. "Vitamin D, neuromuscular control and falling episodes in Australian postmenopausal women". University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0009.
Texto completoŽeljka, Savić. "Uticaj statusa vitamina D na metaboličku aktivnost kosti i koštanu masu kod bolesnika sa alkoholnom cirozom jetre". Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=89494&source=NDLTD&language=en.
Texto completoIntroduction: The term Hepatic osteodystrophy defines a group of metabolic bone diseases associated with underlying chronic liver disease. Alcoholic liver cirrhosis (ALC) is characterized by high incidence of vitamin D deficiency that is proportional to the level of liver failure; however, its role in the pathogenesis of hepatic osteodystrophy has not yet been fully elucidated. The level of 25(OH)D best reflects the vitamin D status. ALC is characterized by changed bone metabolic activity and suppressed bone formation, resulting in the decrease in bone mass. The key topic of interest is the achievement of optimal vitamin D status. The attitude of health professionals towards vitamin D supplementation in alcoholic liver cirrhosis has not yet been clearly defined. The aim of the research: Determining of vitamin D levels, investigating the metabolic activity of the bone and bone mass in patients with alcoholic liver cirrhosis (ALC); Determining the effects of vitamin D3 supplementation at the dose 1000 IU/day during a one-year period in relation to metabolic activity of the bone and bone mineral density (BMD) in the investigated patient population. Patients and methods: The research was conducted at the Clinic for Gastroenterology and Hepatology of the Clinical Centre of Vojvodina in Novi Sad. The research was designed as a prospective interventional study implicating vitamin D3 supplementation at the dose 1000 IU/day to patients with ALC. The investigated patient population (1) encompassed 70 male patients diagnosed with ALC. The patients underwent four examinations (P), that is, research phases: P1 – inclusion of the patient into the study and introduction of vitamin D supplementation; P2, P3 and P4 after 3, 6 and 12 months of vitamin D supplementation treatment, respectively. Each examination included the analysis of liver function, bone metabolism and vitamin D status. At the beginning (P1) and at the end (P4) of the investigation period, bone mineral density (BMD) was measured by means of dual-energy x-ray absorptiometry (DXA) method. Twenty patients dropped out from the research at different stages throughout the investigation period (P1 to P4). The first part of the investigation pertains to the Group of patients who were included into the study (1) and completed the first examination (P1). Fifty patients have completed the entire research according to the foreseen protocol encompassing all examinations and repeated measurements. These patients are considered a Group of patients who completed the research (2) Results: (1): In ALC patients, vitamin D deficiency and decreased osteocalcin levels were established, as well as normal levels of CrossLaps, PTH, total and ionized calcium, phosphorus and magnesium. Osteopenia and osteoporosis were established in 42.65% and 14.71% of patients, respectively. The lowest BMD was measured in the femoral neck in all patients. (2): Vitamin D supplementation resulted in significant increase in 25(OH)D. Analysis of osteocalcin level revealed positive P1/P4 difference, even though the level remained below the lower normal limit. The levels of CrossLaps and PTH revealed negative P1/P4 difference; however, the levels determined at all four measurements were within the reference values. An improvement of BMD for 0.87% was established in lumbar spine, whereas a decrease was noticed in femoral neck (1.87%) and hip (1.65%). Furthermore, an improvement of liver function was established. Conclusions: Improvement of vitamin D status in ALC patients results in an increase of bone formation and improvement of body mass in lumbar spine. Determining the vitamin D status in all patients with ALC is of outmost importance, as well as the vitamin D supplementation of patients with levels of 25(OH)D < 80 nmol/l along with the monitoring of treatment outcome at three-month intervals. Establishment of the diagnosis of alcoholic liver cirrhosis should encompass initial measurement of BMD. In case of vitamin D supplementation treatment, the initial DXA examination should be repeated after the period of one to two years.
Oliveira, Glícia Ribeiro de. "Intervenção assistida por animais com crianças hospitalizadas: efeitos nas condutas comunicativas, sinais vitais e níveis de cortisol". Pontifícia Universidade Católica de São Paulo, 2018. https://tede2.pucsp.br/handle/handle/20890.
Texto completoMade available in DSpace on 2018-03-16T12:15:08Z (GMT). No. of bitstreams: 1 Glícia Ribeiro de Oliveira.pdf: 2925159 bytes, checksum: 5e5fdca9e5026ab15dfe3f82cbc795e7 (MD5) Previous issue date: 2018-03-26
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
INTRODUCTION: This study is aligned with the researches that show that the animal-assisted intervention (AAI) is a possibility to mitigate the possible vulnerability of children when hospitalized and that the presence of a dog contributes to face it, in addition to enhance a sense of well-being. Two complementary studies are presented. PURPOSE: Study 1: To describe comparatively the communicative behavior of children hospitalized with (AAI) and without a dog, in a playful context. Study 2: To describe comparatively the vital signs results and of the cortisol levels in children hospitalized, pre- and post-animal assisted Intervention. METHODS: Study 1: 46 subjects participated in a leisure activity (reading a children's book): 27 in the presence of a dog (Research Group-RG-AAI) and 19 subject without the dog (Control Group-CG). The activity was conducted individually and spontaneously, using the proposal of a ‘Velcometry’, in which the subject would interact with the figures on the book with Velcro straps on the back of the book, on the dog vest (RG), or in the felt board (CG). Collected data were submitted to descriptive and comparative analysis from the analysis of the videos of the RG and CG by the researcher and by 04 judges (02 specialized in the AAI performance and 02 speech-language pathologists). Categories (and their subcategories) of relevant content were established. For the RG and the CG: Non-verbal behavior (body posture; visual contact; facial expression); Interaction and dialogic activity; Motivation for reading. Specifically for the RG: Spontaneous autobiographical reports and photographic records of the AAI. Study 2: 27 subjects participated in a leisure activity (reading a children's book) in the presence of a dog (AAI): The vital signs were measured and material (saliva) was collected to assess the cortisol level before and after the AAI. The collected data were compared from the analysis of the vital signs and cortisol results, before and after the AAI. RESULTS: Study 1: The RG was highlighted in the sample studied: gradual increase of visual and body contacts with the researcher and with the dog in the course of the activity; significant occurrence of happy facial expressions, interaction and dialogy; as well as of spontaneous narratives and motivation for reading. Study 2: In subjects studied, in pre- and post-AAI contexts, vital signs did not show statistically significant differences; however, the reduction of cortisol levels was statistically significant and it was associated to the immune responses on the reduction of stress. CONCLUSION: Study 1: The AAI provided beneficial effects, establishing itself as powerful international resource to address the biopsychic burden involved in the hospitalization process of the child. Study 2: The AAI can mitigate the effects of the stressful environment and enhance the sense of well-being of children hospitalized
INTRODUÇÃO: Esse estudo se alinha com as pesquisas que apontam que a Intervenção Assistida por Animais (IAA) seja uma possibilidade que amenize a possível vulnerabilidade de crianças diante à situação da hospitalização e de que a presença de um cão contribui para o seu enfrentamento, além de potencializar a sensação de bem-estar. São apresentados 2 estudos complementares. OBJETIVOS: Estudo 1: Descrever comparativamente as condutas comunicativas de crianças hospitalizadas na presença (IAA) e na ausência de um cão, em contexto lúdico. Estudo 2: Descrever comparativamente os resultados da aferição de sinais vitais e mensuração dos níveis de cortisol de crianças hospitalizadas, pré e pós Intervenção Assistida por Animais. MÉTODO: Estudo 1: 46 sujeitos participaram de uma atividade lúdica (leitura de um livro infantil): 27 na presença de um cão (Grupo Pesquisa – GP - IAA) e 19 sujeitos sem o cão (Grupo Controle – GC). A atividade ocorreu individualmente, de forma espontânea, utilizando a proposta do Velcômetro, em que o sujeito aderia figuras do livro com velcros colados no verso, no colete do cão (GP), ou no quadro de feltro (GC). Os dados coletados foram submetidos à análise descritiva e comparativa a partir da análise dos vídeos do GP e GC pela pesquisadora e 04 juízes (02 especialistas na atuação em IAA e 02 fonoaudiólogas). Estabeleceram-se categorias (e respectivas subcategorias) relevantes de conteúdo. Para o GP e GC: Comportamento não verbal (postura corporal; contato visual; sorrisos); Interação e atividade dialógica; Motivação para a leitura. Para o GP, especificamente: Relatos autobiográficos espontâneos e Registros fotográficos da IAA. Estudo 2: 27 sujeitos participaram de uma atividade lúdica (leitura de um livro infantil) na presença de um cão (IAA). Foram realizadas aferições de sinais vitais e coleta de material (saliva) para mensuração do nível de cortisol pré e pós IAA. Os dados coletados foram comparados a partir da análise dos resultados dos sinais vitais e cortisol, pré e pós IAA. RESULTADOS: Estudo 1: Na amostra estudada, evidenciou-se no GP: gradativo aumento dos contatos visual e corporal do sujeito com a pesquisadora e com o cão no decorrer da atividade; ocorrência significativa de sorrisos, de interação e dialogia; de narrativas espontâneas e motivação para a leitura. Estudo 2: Nos sujeitos estudados, nos contextos pré e pós IAA, os sinais vitais não apresentaram diferenças estatisticamente significativas, entretanto, a redução dos níveis de cortisol foi estatisticamente significativa, associando-se às respostas imunológicas diante da diminuição do estresse. CONCLUSÃO: Estudo 1: A IAA teve efeitos benéficos, configurando-se como recurso interacional potente para lidar com a situação de sofrimento biopsíquico envolvido no processo de hospitalização da criança. Estudo 2: A IAA pode minimizar os efeitos do ambiente estressor e potencializar a sensação de bem-estar de crianças hospitalizadas
Ramez-Baydoun, Lubna Lulu. "Novel chelating agents for therapeutic use". Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406043.
Texto completoBetz, Jennifer. "The Use of Improvisation in Therapeutic Practices". Kent State University Honors College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1557312650223249.
Texto completoXiang, Hong. "Effects of myo-inositol and, or triiodothyronine (T₃) treatment on cardiac dysfunction and elevated myocardial lipid levels in STZ-diabetic rats". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26675.
Texto completoPharmaceutical Sciences, Faculty of
Graduate
Bourne, Nicola Elizabeth. "The use of vitamin E in sustainable milk production". Thesis, Royal Veterinary College (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413433.
Texto completoAlder, Louise B. A. "Immunoregulatory properties of polyclonal immunoglobulin for therapeutic use". Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361937.
Texto completoLloyd, Jonathan. "The therapeutic use of metaphor : a heuristic study". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/the-therapeutic-use-of-metaphor-a-heuristic-study(a020949f-3653-4812-af1d-ccbf49e53f98).html.
Texto completoNgwa, Conelius. "Use of peptide nucleic acids as therapeutic agents". Thesis, Aston University, 2014. http://publications.aston.ac.uk/24385/.
Texto completoMarnewick, Jeanine Lucasta. "Cancer modulating properties of unique South African herbal teas (rooibos and honeybush) in short term in vitro and in vivo carcinogenesis assays". Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/21888.
Texto completoENGLISH ABSTRACT: This thesis provides the first scientific evidence on the cancer modulating properties of two unique South African herbal teas, rooibos (Aspalathus Iinearis) and honeybush (Cyclopia intermedia) utilizing in vitro as well as in vivo carcinogenesis assays by: • Demonstrating the in vitro antimutagenic activity of aqueous extracts of the herbal teas against the metabolic activated mutagens, 2-acetylaminofluorene (2- AAF) and the mycotoxin, aflatoxin B1 (AFB,) as well as, to a certain extent, against the direct acting mutagen, hydrogen peroxide, utilizing the Salmonella typhimurium mutagenicity assay. • Increasing the activity of hepatic drug metabolizing enzymes, glutathione Stransferase alpha and UPD-glucuronosyl transferase, and reduced the oxidative stress by stabilizing the level of reduced glutathione (GSH) resulting in an increased hepatic reduced to oxidized glutathione ratio (GSG:GSSG). No toxic effects were noticed in rats consuming the herbal teas for 10 weeks as their sole source of drinking fluid. • Demonstrating the ex vivo modulation of 2-AAF- and AFB1-induced mutagenesis by sub- cellular hepatic fractions of rats consuming the herbal teas in the Salmonella mutagenicity assay. Hepatic cytosolic fractions protected against mutagenesis of both mutagens, while the microsomal fractions exhibited a reduced capacity to metabolize AFB1 to its active mutagenic metabolite. • Providing evidence for the in vivo modulation of tumour promotion using the liver as well as the two-stage skin carcinogenesis animal models. The unprocessed herbal teas arrested proliferation of the placental form of glutathione-Stransferase (GSTP+) altered cells as well as reduced the total number of enzyme altered foci in the liver of rats. Topical application of polyphenolic fractions of the various herbal teas prior to 12-0-tetra-decanoylphorbol-13-acetate (TPA) tumour promotion, reduced tumour formation in mouse skin initiated with 7,12-dimethylbenz[ ajanthracene (DMBA). The protective effect was illustrated by a decreased tumour incidence, a reduction in tumour volume as well as a delayed onset of tumour development. The f1avanol/proanthocyanidin content of the fractions could playa major role in the protection against skin tumour promotion. • Proposing possible mechanisms whereby rooibos and honeybush herbal teas could exert their cancer modulating properties with respect to in vitro and ex vivo antimutagenicity, in vivo oxidative status and reduced tumour promotion. • Providing evidence that the herbal teas mimic the cancer modulating properties of green and black teas although differences exist, presumably due to differences in the polyphenolic constituents. • Suggesting that rooibos and honeybush herbal teas may play an important role as chemopreventive agents in the modulation of cancer.
AFRIKAANSE OPSOMMING: Hierdie tesis bevat die eerste ondersoek na die effek van waterige en polifenoliese ekstrakte van rooibos (Aspalathus Iinearis) en heuningbos (Cyclopia intermedia) op verskeie aspekte van kankerontwikkeling. Die twee kruietees is uniek aan Suid-Afrika en kan 'n belangrike rol speel in die voorkoming van kanker. Verskillende in vitro so wei as in vivo studies het die volgende getoon: • Antimutageniese aktiwiteite teen die metabolies-geaktiveerde mutagene, 2- asetielaminofluoreen (2-AAF) en die mikotoksien, aflatoksien B1 (AFB1) in die Salmonella fyphimurium mutagenisiteitstoets. 'n Beperkte mate van beskerming is ook verleen teen die oksidatiewe mutageen, waterstofperoksied, sonder metaboliese aktivering. • Verhoogde aktiwiteite van die fase II ensieme, glutatioon S-tranferase alfa en UDP-glukuronidase, wat liggaamsvreemde verbindings metaboliseer. Die kruietees verlaag die oksidasietoestand soos weerspieel word deur 'n toename van gereduseerde glutatioon tot die geoksideerde vorm in die lewer van rotte wat 10 weke hierdie kruietees gedrink he!. Die kruietees het geen toksiese uitwerking op die rotte gehad nie. • Antimutageniese aktiwiteite van subselluiE~re fraksies van die lewer teenoor 2- AAF en AFB1 in die Salmonella toets. Die sitosolfraksie van die rotlewer bied beskerming teen die ge"induseerde mutagenese van beide mutagene, terwyl die mikrosomale fraksie ook die metaboliese aktivering van AFB1 na die aktiewe mutageniese metaboliet verminder. • In vivo modulering van kankerpromosie met behulp van bekende rotlewer en muisvel kankerontwikkelingsmodelle. In die lewermodel het die ongeprosesseerde kruietees beide die ontwikkeling en getal van GSTP+ fokusse onderskeidelik vertraag en verminder. In die geval van die velkankermodel het aanwending van polifenoliese fraksies van die kruietees beskerming gebied teen die ontwikkeling van velkankers by muise. Die aantal en grootte van die tumors het afgeneem terwyl die verskyning daarvan ook vertraag is. • Verskeie meganismes waardeur rooibos- en heuningboslee moonllik kanker kan moduleer word voorgeslel. Verskille in die polifenoliese sameslelling asook hul onderskeie konsenlrasies kan 'n belangrike rol speel in die kankerveranderende effekle van die lees. • Oal gereelde inname van rooibos- en/of heuningboslee moonllik 'n belangrike rol kan speel in die voorkoming van dieel- en omgewings-geYnduseerde kankers.
Cheng, Ka-wing y 鄭家榮. "Preventive potential and mechanism of dietary phenolics on the formation of mutagenic heterocyclic amines". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B4284177X.
Texto completopublished_or_final_version
Biological Sciences
Doctoral
Doctor of Philosophy
Stapleton, Graham Neil. "A study of the effects of sucralfate in the bile duct litigated pig peptic ulcer model with particular reference to the effects on the physico-chemical properties of gastric mucus and including comparisons with famotidine and misoprostol". Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/25727.
Texto completoWilkins, Jennie P. "Relationship between maternal prenatal vitamin use and infant iron status". Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2381.
Texto completoTitle from document title page. Document formatted into pages; contains vi, 43 p. Vita. Includes abstract. Includes bibliographical references (p. 34-36).
Thomas, Becky L. "The Use of Therapeutic Rituals in Substance Abuse Treatment". DigitalCommons@USU, 2001. http://digitalcommons.usu.edu/etd/2712.
Texto completoKjellin, Jessica y Sara Norman. "Arbetsterapeutstudenters utvecklande av ”therapeutic use of self” - En litteraturstudie". Thesis, Örebro universitet, Institutionen för hälsovetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84409.
Texto completoTreece, Christine A. "Psychologists' Use of Dogs in Psychotherapy: A Therapeutic Exploration". Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1554402231989459.
Texto completoHakala, John C. "The therapeutic use and effectiveness of humor in psychotherapy". Online version, 1998. http://www.uwstout.edu/lib/thesis/1998/1998hakalaj.pdf.
Texto completoParsons, Ann Bernardene. "Designing a resource guide for horticultural therapy programs at botanical gardens and arboreta". Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/104531.
Texto completo余詩德 y Sze-tak Yu. "Effects of Chinese green tea and tea catechins on lipolysis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31969677.
Texto completoZhang, Jingjing y 张晶晶. "The anti-cancer properties of cyclometalated gold(III) complexes and organogold(III) supramolecular polymers". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208171.
Texto completopublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Roberts, Jacintha. "Studies on bisphosphonate elution from orthopaedic implants". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112582.
Texto completoKilinkissa, Ornella Edlyne Youdaga. "Physical chemical properties of selected pharmaceutical co-crystals". Thesis, Cape Peninsula University of Technology, 2014. http://hdl.handle.net/20.500.11838/731.
Texto completoThe solid state modification of a given active pharmaceutical ingredient is a desired way to alter its physicochemical properties, such as solubility or bioavailability. The solubilitymelting point relationship of the ensuing co-crystal or salt is not fully understood. In this thesis, a series of model co-crystals and pharmaceutical co-crystals and salts of baclofen were investigated. The model co-crystals were prepared from 4,4’-bipyridine (BIPY) and 1,2-bis(4-pyridyl)ethane (ETBIPY) used as host compounds which were combined with a series of carboxylic acids as co-formers, such as p-toluic acid (PTA), rac-phenylbutyric acid (racPBA), racemic and S-phenylsuccinic acid (racPSA and S-PSA, respectively). In the second part, six new multicomponent crystals of baclofen (BAC, (RS) 4-amino-3-(4- chlorophenyl)-butanoic acid), were prepared with mono- and dicarboxylic acids: two pharmaceutical co-crystals obtained with benzoic acid (BAC•BA) and p-toluic acid (BAC•PTA) and four pharmaceutical salts with 1-hydroxy-2-naphthoic acid, (BAC+)(HNA-), oxalic acid, 2(BAC+)(OA2-), maleic acid, (BAC+)(MA-) and p-toluene sulfonic acid, (BAC+)(PTSA-)•IPA. The compounds prepared were analysed by single crystal and powder X-ray diffractometry, differential scanning calorimetry and their solubility was measured in water and ethanol. From the analysis of the model co-crystals it was concluded that their aqueous solubility is inversely related to the melting point values and this can be explained by packing features. Also, the introduction of a chiral building block, compared to its racemic counterpart, is a valuable way to limit the formation of the intermolecular interactions in the new multicomponent crystal and thus decrease the efficiency of the packing which eventually leads to lower melting points and better solubility. The analysis of the baclofen crystals suggests that a strong, robust and predictable hydrogen bonding network with a combination of molecular building blocks which show acceptable molecular flexibility is a good recipe for successful co-crystal design.
Sinha, S. K. "Vitamin E and periventicular haemorrhage in preterm babies". Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234205.
Texto completoBertrand, Erin Marie. "Insights into vitamin B₁₂ production, acquisition, and use by marine microbes". Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/73797.
Texto completoCataloged from PDF version of thesis.
Includes bibliographical references.
The distribution and magnitude of marine primary production helps determine the ocean's role in global carbon cycling. Constraining factors that impact this productivity and elucidating selective pressures that drive the composition of marine microbial communities are thus essential aspects of marine biogeochemistry. Vitamin B₁₂, also known as cobalamin, is a cobalt containing organometallic micronutrient produced by some bacteria and archaea and required by many eukaryotic phytoplankton for methionine biosynthesis and regeneration. Although the potential for vitamin B₁₂ availability to impact primary production and phytoplankton species composition has long been recognized, the lack of molecular-level tools for studying B₁₂ production, use and acquisition has limited inquiry into the role of the vitamin in marine biogeochemical processes. This thesis describes the development of such tools and implements them for the study of B₁₂ dynamics in an Antarctic shelf ecosystem. Nucleic acid probes for B₁₂ biosynthesis genes were designed and used to identify a potentially dominant group of B₁₂ producers in the Ross Sea. The activity of this group was then verified by mass spectrometry-based peptide measurements. Then, possible interconnections between iron and B₁₂ dynamics in this region were identified using field-based bottle incubation experiments and vitamin uptake measurements, showing that iron availability may impact both B₁₂ production and consumption. Changes in diatom proteomes induced by low B₁₂ and low iron availability were then examined and used to identify a novel B₁₂ acquisition protein, CBA1, in diatoms. This represents the first identification of a B₁₂ acquisition protein in eukaryotic phytoplankton. Transcripts encoding CBA 1 were detected in natural phytoplankton communities, confirming that B₁₂ acquisition is an important part of phytoplankton molecular physiology. Selected reaction monitoring mass spectrometry was used to measure the abundance of CBA1 and methionine synthase proteins in diatoms cultures, revealing distinct protein abundance patterns as a function of B₁₂ availability. These peptide measurements were implemented to quantify methionine synthase proteins in McMurdo Sound, revealing that there is both B₁₂ utilization and starvation in natural diatom communities and that these peptide measurements hold promise for revealing the metabolic status of marine ecosystems with respect to vitamin B₁₂.
by Erin Marie Bertrand.
Ph.D.
Zhang, Xiao y 張瀟. "The effects of l-tetrahydropalmatine and rhynchophylline, alkaloids derived from herbal medicines, on cellular and molecular neurotoxicityof cocaine in PC12 cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43572248.
Texto completoWang, Ning Michael y 王宁. "The preventive and curative potential of berberine and coptis on humanhepatocellular carcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079637.
Texto completopublished_or_final_version
Chinese Medicine
Doctoral
Doctor of Philosophy
Chan, Chung-ling Pansy y 陳鍾靈. "The long-term effects of yoga and aerobic exercise on cognitive function and clinical symptoms in early psychosis : a follow-up randomized control trial". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206585.
Texto completopublished_or_final_version
Psychological Medicine
Master
Master of Psychological Medicine
Hall, Clifford Michael. "Relative efficacy of hydrocortisone and methylprednisolone in acute severe asthma". Thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/25562.
Texto completoMeyer, Kevin J. "The relationship between therapists' use of humor and therapeutic alliance". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186189837.
Texto completoCowell, Richard Pennant Wynn. "Studies on the therapeutic use of pacing in myocardial dysfunction". Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299473.
Texto completoCarvalho, George. "Studies on the inotropic effect of insulin and glucose : a new diet for the ischemic heart?" Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101840.
Texto completoBraun, Marle. "Total antioxidant capacity of stewed tomato and onion flavoured with parsley: effect of thermal household processing". Thesis, Cape Peninsula University of Technology, 2006. http://hdl.handle.net/20.500.11838/766.
Texto completoFruit and vegetables are the major antioxidant contributors to the diet Antioxidants assist in the prevention of oxidative damage in the body and may as a result prevent the causation of degenerative diseases. Thermal household processing plays an integral part in South African consumers' lives, as most fruit and vegetables consumed are processed at home. Consumers' perceptions that food processing causes nutrient losses, especially of vitamin C, have been corroborated by studies that investigated thermal household processing of single foods or that of industrial processing. No studies have determined the effect of thermal household processing on mixed dishes. A popular consumed South African mixed dish, namely, stewed tomato and onion flavoured with parsley, was investigated by using three recipes, each using a different preparation method. The traditional recipe for the preparation of stewed tomato and onion was modified (control recipe) to contain parsley. Two other recipes (Recipe 1 and 2) were compiled based on the recipe formulation of the control recipe but differed in the preparation methods used. In Recipe 1, raw onion was added to cooked tomato and in Recipe 2, sauteed onions were added to cooked tomato.
Hu, Yaxin y 胡亞欣. "Biophysical interactions between therapeutic ultrasound and live cell". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208032.
Texto completopublished_or_final_version
Electrical and Electronic Engineering
Doctoral
Doctor of Philosophy
Zhang, Jingxuan y 张静璇. "Therapeutic landscape in high-density urban environment". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4754479X.
Texto completopublished_or_final_version
Architecture
Master
Master of Landscape Architecture
Zolfaghari, Sara S. "The relationship between folic acid, vitamin B12, and vitamin B6 intakes and depression in women who use hormonal oral contraceptives". Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1604887.
Texto completoDepression is a leading cause of disability and mortality worldwide, especially for women. No nutrition recommendations exist for depression. Oral contraceptives (OCs) have become the leading form of pregnancy prevention in the United States. Studies have associated OC use with impaired nutrient status, specifically folate, vitamin B12, and vitamin B6, which also affect brain functions. Dietary folate, vitamin B12, and vitamin B6 self-reported intakes were used to determine the relationship between depression in women who used OCs (n = 34) in a selected cohort ( n = 409) from the National Health and Nutrition Examination Survey, 2003–2008. OC users were more depressed than non-OC users; depression was associated with various quartile levels of vitamin intake (p <.001). No benefit was observed with intakes which exceeded RDAs for non-OC users; OC users were less depressed when intakes exceeded RDAs for folate, vitamin B12, and vitamin B6 by 13%, 75%, and 7%, respectively.
Peternelli, Loris. "The relationship between emotionality and in-session therapeutic phenomena". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0019/NQ37011.pdf.
Texto completoChan, Wing-yan Veronica y 陳詠恩. "An examination of neuroprotective effects of 17B-estradiol and extracts from Panax Quinquefolius L., Ginkgo Biloba and HypericumPerforatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)induced nigral-striatal neuronal degeneration". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122720X.
Texto completoO’Gorman, Maurice R. G. "Reduced in vitro IgG secretion following in vivo injection of interferon (wellferon R) in multiple sclerosis patients". Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24876.
Texto completoMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Faghihi, Shahabeddin. "Effects of crystal size and orientation of novel titanium-based substrates on cell adhesion : implication for medical implants". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111882.
Texto completoNovel bulk nano-structured titanium substrates were produced by the process of high-pressure torsion (HPT). These materials have a significant advantage compared to conventional titanium-based materials by having higher surface wettablity, mechanical properties as well as a distinct surface oxide layer and atomic structure. A co-culture system was adapted to investigate the differential response of pre-osteoblast and fibroblast cell lines to titanium and titanium dioxide single-crystal substrates.
The results of this study provide clear evidence that crystal size and specific crystallographic orientation can be used to improve cell adhesion and proliferation. The nanostructured titanium substrates show strong interaction with pre-osteoblast cells as evident by the higher expression of fibronectin and the formation of extensive focal adhesion. Differential cell behaviour of pre-osteoblasts and fibroblasts are observed in cultures grown on the substrates with specific crystallographic orientations. The degree of cell attachment of the pre-osteoblasts is considerably higher on Ti-(1120) crystal face compared with the fibroblasts. These findings have profound implications for the improved osseointegration and inhibition of fibrosis leading to long-term implant consolidation and stability.