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Liu, Jian Lin, Heng Gen Shen, Zhen Liang, Rui Zhou y Min Fang. "Simulated Analysis of Exploiting Space Flow Field on the Environmental Wind Influence in the Open Pit Mine". Advanced Materials Research 610-613 (diciembre de 2012): 1078–82. http://dx.doi.org/10.4028/www.scientific.net/amr.610-613.1078.
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This paper focuses on computational fluid dynamics (CFD) simulation of the dynamic exploited influence of wind field in the open pit quarry. We have picked up 3 normal exploitation parameters, e.g. the exploited depth z, the type of small hills and the measured velocity u1, 7 simulated experiments have been done by software Fluent as well. In our experiments, the features of velocity field around the mine are shown, with the effects of open pit quarry, so as to analyze the changes of wind speed when it gets through this mine. To be exact, it will be possible to deduce there is negative correlation between the velocity decreased gratitude and the exploited depth. Besides, with the shelter effect of a small hill, the wind speed tends to slow down near this hill, and turn back to rise until the flow leaves the hill far away. The velocity decreasing has positive correlation with the measured velocity u1, and the reverse flow is more likely to appear with higher u1.
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Wang, Min, Xing Shi, Wei-Pu Cheng, Fei-Hu Ma, Si-Miao Cheng y Xuan Kang. "Clinical Study on Efficiency of Using Traditional Direct Bonding or OrthGuide Computer-Aided Indirect Bonding in Orthodontic Patients". Disease Markers 2022 (29 de septiembre de 2022): 1–5. http://dx.doi.org/10.1155/2022/9965190.
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Objective. This study aims to clinically investigate and compare the therapeutic effects and treatment cycle between traditional direct bonding and OrthGuide computer-aided indirect bonding in orthodontic treatment. Methods. Forty patients treated at the Department of Orthodontics, Beijing Rytime Dental Hospital between July 1, 2016, and December 31, 2019, were included. The patients were divided into a control group ( n = 20 , traditional direct bonding) and a test group ( n = 20 , OrthGuide computer-aided indirect bonding). The American Board of Orthodontics (ABO) measurement was performed on patients using Uceph cephalometric analysis software to compare intragroup and intergroup differences, and the treatment cycles of all patients were recorded. Results. After treatment, U1-NA (mm), ∠U1-SN (°), LL-EP (mm), and UL-EP (mm) in the control group were significantly lower than before treatment, and there was no significant difference in other ABO measurement indexes, while the test group showed no marked difference in all ABO measurements between pre- and posttreatment. Further, intergroup comparison showed no significant difference in ABO measurements in pre- and posttreatment between the two groups. The test group had a shorter treatment cycle than the control group, with an average treatment cycle of 21.20 ± 7.14 months in the control group and 17.17 ± 4.16 months in the test group. Conclusion. There was no significant difference in the therapeutic effects between the direct and indirect bonding techniques. However, OrthGuide computer-assisted indirect bonding demonstrated a significantly shorter treatment cycle and might be more efficient than traditional direct bonding.
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Guo, Zhi Cheng, Yu Zhong Li, Qiao Zhen Li, Chun Ying Xu, Yi Wei Dong y Fu Li Fang. "Effect of Chemical Fertilizer and Compost on Natural 15N Abundance of Tomato Leaves and Fruits". Advanced Materials Research 524-527 (mayo de 2012): 2238–41. http://dx.doi.org/10.4028/www.scientific.net/amr.524-527.2238.
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Organic farming is a good way to reduce environmental pollution. However, no related detection of fertilizer applications, which are extremely important in organic farming, exists. The δ15N value of chemical fertilizer (–3.8 to +2‰) is far lower than compost (>+10‰). Thus, natural 15N abundance (δ15N) in leaves and fruits may be used to reveal the application of N fertilizer. In this experiment, six treatments were laid out: 635 g (C1), 952 g (C2), and 1270 g (C3) of compost were applied as basal fertilizer in each pot. Alternately, 10.7 g (U1), 16 g (U2), and 21.3 g (U3) of urea were applied as basal fertilizer and 10.7 g (U1), 16 g (U2), and 21.3 g (U3) urea were applied as top-dressing, respectively, in each pot. C1 and U1, C2 and U2, and C3 and U3 had equal amounts of nitrogen fertilization. In all three fertilizer levels, the leaves and fruits sampled from the U group had significantly lower values than those sampled from the C group within the same period. The δ15N values of the leaves and fruits from the C group decreased slowly. The δ15N values of leaves sampled at 40 days after transplanting were fairly low. The δ15N values of leaves and fruits from the U group increased initially, due to the small amounts of urea left, which then led the plants to absorb N from the culture substrates. However, the δ15N values of leaves and fruits from the U group decreased rapidly after the top-dressing was applied, where the minimum values occurred during the final stage.
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Norhidayah, A., A. Noriham y Mohamad Rusop. "Physical and Thermal Properties of Zingiber officinale Rosc. (Ginger) Rhizome Fine Particle as a Function of Grinding System". Advanced Materials Research 832 (noviembre de 2013): 527–32. http://dx.doi.org/10.4028/www.scientific.net/amr.832.527.
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In this study,Zingiber officinale(ginger) rhizome fine particles were prepared by using food processor, hammer mill and planetary ball mill and tested for their physical and thermal properties. The physical changes by means of particle size, surface morphology, FT-IR and thermal stability (TGA) were investigated. The size reduction method had a distinct effect on physical and thermal properties of ginger rhizome tested. Average particle size of ginger rhizome after using food processor and hammer mill was around 50µm and 20µm respectively while after using planetary ball mill the ginger rhizome was successfully reduced to nanoscale (222.3 nm). Higher degree of granule surface fractured was observed as a result of a planetary ball milling process based on FESEM images. There were also some notable differences of FT-IR spectra detected. By comparing the spectra, the stretching vibration peak of OH at 3292 cm-1[U1]and the symmetric stretching vibration peak of the NO2and C=C at 1369 – 1639.51cm-1 for ginger rhizome ground using food processor were disappeared. Yet, presence of possibly strong alkenes group (in the range 2850 – 2970cm-1) were observed in all samples tested. Ginger rhizome particles obtained from hammer milling process were found to be more stable to thermal effect where the decomposed temperature was 276.64°C as compared to samples milling using food processor and planetary ball mill. These results would provide useful insight for exploring the potential applications of ginger rhizome fine powder as functional food ingredient as well as in pharmaceutical applications. [U1]Check typing of superscript.
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Li, Fang y Zeng Lu Qi. "Kinetic Analysis on Rotating Biological Contactor Treatment of Organic Matter". Advanced Materials Research 599 (noviembre de 2012): 322–25. http://dx.doi.org/10.4028/www.scientific.net/amr.599.322.
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This paper adopts a 3-stage rotating biological contactor (RBC), studies kinetic analysis on RBC treatment of organic matter .Water temperature 25 °C and hydraulic retention time (HRT) 5h , COD concentration of influent varies from about 400 to 700mg / L, the average COD removal rate is 85% . According to Monod and Michaelis-Menten formula, organic matter removal kinetics equation in the first stage of RBC can be catched. When DO≥2mg/L, organic matter removal kinetic equation: U1=7.02S1/( S1+640.70), DO<2mg/L, organic matter removal kinetic equation: U2=35.97S2/( S2+4848.92) .Where U is substrate removal rate of unit area of disc, S is the organic matter concentration of substrate. Some reference values of the equation are very useful for practical application of RBC.
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Zheng, Yun Wu, Li Bin Zhu, Ji You Gu y Yan Hua Zhang. "Study on the Thermal Stability of MUF Co-Polymerization Resin". Advanced Materials Research 146-147 (octubre de 2010): 1038–42. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.1038.
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Curing is the key to the bonding, the study indicate that: curing effect on the glue bond strength, formaldehyde emission as well as Productive Efficiency; the better curing system can ensure the Productive Efficiency in basic to decrease the FE. This paper considered the production practice, studied the curing properties of different MUF resin with TGA. The experimental result: Different curing systems, made different curing process. For A curing system, curing rate is the fastest, the degree of curing is best. Cured stability is well. While in the C curing system, Because of their poor degree of cross-linking, poly-condensation cross-linked imperfect. While, Along with the increasing of n(F):n(U1), initial decomposition temperature increased, the maximum rate of mass loss moved to higher temperature, mass loss declined, decomposition activation energy increases, aging resistance increased.
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Banerjee, Ayan, Alok Ranjan, Mukunda Kumar, Sushil Kumar, Akash Bansal y Mala Mahto. "Antinuclear antibody (ANA) positivity pattern by line immunoassay in a hospital from eastern India: Update from a laboratory perspective". Journal of Family Medicine and Primary Care 13, n.º 4 (abril de 2024): 1254–61. http://dx.doi.org/10.4103/jfmpc.jfmpc_1170_23.
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ABSTRACT Context: The existence of more than one antibody in systemic autoimmune rheumatic diseases (SARDs) or connective tissue disease (CTD) along with features of more than one autoimmune disease (AD) in an individual is suggestive of overlap syndrome (OS). Line immunoassay (LIA) can target many autoantibodies in a single approach, thus making the identification of OS feasible. Aims and Objectives: This study aimed to identify the pattern of distribution of antinuclear antibodies by LIA prevalent in a hospital population in eastern India and identify common forms of SARD in this belt based on laboratory findings. Material and Methods: A total of 1660 samples received for ANA profile testing by LIA were analysed. Statistical Analysis: Factor analysis was performed with factor loading scores used in the k-means algorithm to identify clustering of various autoantibodies. Results: U1-snRNP positivity was the highest at 16.69%, and the least frequent autoantibody noted was anti-Jo-1 at 0.71% positivity. Based on the outcome of factor analysis, three clusters were determined. Cluster 1 showed a predominance of anti-PM/Scl antibodies, cluster 2 showed a predominance of anti-dsDNA, anti-histone, anti-SmD1, anti-nucleosomes, anti-PCNA, anti-Po, anti-SSA/Ro52, anti-SSA-Ro60, anti-SSB/La, anti-Scl-70, anti-Mi-2, anti-Ku and anti-AMA-M2, and cluster 3 showed a predominance of anti-U1-snRNP. Conclusions: Mixed connective tissue disease (MCTD) and overlap syndrome (OS) are prevalent more than pure form of an AD in our study population. OS may be missed out by monospecific immunoassays and hence adds to diagnostic challenges. LIA may be more useful in identifying specific autoantibodies by a single approach rather than monospecific immunoassays in populations after a positive screen by indirect immunofluorescence (IIF).
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Zhou, Qiao Fang, Ying Chun Cai, Yan Xu y Xiang Ling Zhang. "Preliminary Exploration of On-Line Measuring Layer Moisture Content with Electrical Resistance Method during Wood Drying". Advanced Materials Research 261-263 (mayo de 2011): 480–84. http://dx.doi.org/10.4028/www.scientific.net/amr.261-263.480.
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Electrical resistance method was used to detect layer moisture content across the thickness of Larch (Larix gmelinii) specimen during drying, and the temperature of the same layers and the environment were also measured by remote temperature scanner. During the drying process, layer moisture content was obtained from other Larch specimens with slicing method. Layer moisture content measured with electrical method was compared with that acquired with slicing method. Results showed that the wood center temperature was more suitable than the environment temperature as compensated temperature to amend moisture content measuring with electrical resistance method; variation of layer moisture content of Larch specimen could be more or less measured with electrical resistance method, and had a relatively good agreement with that acquired with slicing method except that u15 was 3% higher than U1 and u3 was 4% higher than U3 in the middle stage of drying.
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Samsu, Samsu, Henry N. Barus y Uswah Hasanah. "THE EFFECT OF SOILAGGREGATE SIZE AND P DOSAGE ON AMF SPORES NUMBER IN SHORGUM (Sorghum bicolor L.)". AGROLAND: The Agricultural Sciences Journal 4, n.º 1 (14 de febrero de 2018): 20. http://dx.doi.org/10.22487/j24077593.2017.v4.i1.9399.
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Mycorrhiza is a biological agent to help fertility of soil and plants. Application of mycorrhiza on the land in the form of inoculum is often used in agricultural land in the name of quality of inoculum that also influenced by the content of existing spores. One of them is growing medium. This study aimed to study the effect of soil aggregate size and P dosage on the number of mycorrhizal spores in sorghum plants. The research design used was Randomized Block Design consisting of 2 factors. First factor was soil aggregate size(μm) which consisted of 4 treatments: U1 = < 2000, U2 = 500 - 1000, U3 = 200 - 500, U4 = < 200, and second factor was P dosage: 100 mg/kg and 300mg/kg. Each treatment combination was repeated 3 times so that there were 24 units of experimental unit. Observation parameters included the percentage of the infected root, number of spores, plant height and dry weight of the plant. The research was conducted in Greenhouse and Agronomy Laboratory of Agricultural Faculty of Tadulako University Palu. The various sizes of soil aggregates do not affect the amount of arbuscular mycorrhizal spores in sorghum plants. P 100 mg/kg or f P 300 mg/kg dosage used do not address the effect of the mycorrhizal spores. There is no interaction between soil aggregate size and P dosage to the amount of mycorrhizal spores in sorghum plants.
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Zheng, Yun Wu, Li Bin Zhu, Ji You Gu, Zhi Feng Zheng y Yuan Bo Huang. "Study on the Curing Characteristics of MUF Co-Polymerization Resin". Advanced Materials Research 183-185 (enero de 2011): 2124–28. http://dx.doi.org/10.4028/www.scientific.net/amr.183-185.2124.
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Curing is the key to the bonding, this paper considered the production practice, studied the curing properties of different MUF resin under the different curing agent with DSC. The experimental results show that: The characteristics temperature of curing reaction is closely related to the β. With the increase of β, the initial and peak temperature is moving to the high-temperature, the curing time became shorter; the range of curing temperature became much wider. At the same time, the curing peaking temperature was decreased and the Enthalpy integral of curing reaction was reduced first then increased with the increased of the amount of curing agent. When the amount of curing agent occupied 4.0%-6.0% of the MUF resin, the pH was decreased mostly, and the curing reaction rate run up quickly Along with the increasing of n (F): n (U1), the To, Tp and Ti are going ahead distinctly after hardening. At the same time, both activation energy and reaction order are all decreased, absorbed heat is dropping too. So, curing technics became easily.
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Kertorahardjo, Sapto P., Harold Vincent y Putranta H. Duta. "Structure Analysis on Artificial Reefs". Applied Mechanics and Materials 874 (enero de 2018): 27–34. http://dx.doi.org/10.4028/www.scientific.net/amm.874.27.
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Most of the artificial reefs that have been developed in the world are the concrete structure. Regarding economical and practical consideration of artificial reefs, Indonesian government - Ministry of Marine Affairs and Fisheries - has proposed a new material to make an artificial habitats including artificial reefs made from polypropylene plastics (PP). However, diminishing approximately 80% of the weight structure compare to concrete structure has created new challenges to maintain the underwater structure with similar function. Moreover, the use of less weight material for artificial reefs structure will have impact on the structure responses.The structure responses due to sea bottom current and tidal stream velocity have been evaluated at several conditions. Dynamic pressure calculation was applied gradually as external load from a simple part to whole complex structure. Stresses and strains occur at some nodes as the structure critical area, within the same time frame, displacement of its elements describe physical characteristic response. Boundary conditions was encastred the sinker- bottom structure (U1 = U2 = U3 = UR1 = UR2 = UR3 = 0). In conclusion, for input of sea bottom current velocity u = 0.2 m/s the results for maximum stress are below the material’s yield stress hence its elasticity is relatively adequate to prevent permanent deformation. The result also showed some critical part of the structure that has high value on stress should be consider as the current velocity increase. Moreover increasing input and frontal area will significantly affect the drag force which will add load on the structure.
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Chen, Y., W. Y. Lu y D. Liu. "AB0597 CLINICAL SIGNIFICANCE OF ANTI-RHEUMATOID ARTHRITIS 33 ANTIBODY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS". Annals of the Rheumatic Diseases 82, Suppl 1 (30 de mayo de 2023): 1499.1–1499. http://dx.doi.org/10.1136/annrheumdis-2023-eular.638.
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BackgroundEvidence initially showed that anti-rheumatoid arthritis (RA) 33 antibodies were highly specific for the diagnosis of RA[1]. Later studies reported that anti-RA33 was present in various connective tissue diseases (CTDs)[2]. However, the clinical significance of anti-RA33 antibodies in CTDs is still obscure.ObjectivesTo explore the clinical significance and diagnostic value of anti-RA33 antibodies in CTDs, especially systemic lupus erythematosus (SLE).MethodsA total of 565 patients with positive anti-nuclear antibodies who had been tested for anti-RA33 antibodies were included in the study. These patients were classified into RA33-positive and RA33-negative groups according to the anti-RA33 results. The association between anti-RA33 and the clinical features of CTDs was examined. Additionally, receiver operating characteristic (ROC) analysis was performed to explore the diagnostic value of anti-RA33 antibodies in SLE and SLE-related organ involvement.ResultsSLE was the most common disease in CTD patients positive for anti-RA33 (48.8%). Compared with the RA33-negative group, the proportion of patients with SLE was significantly higher in the RA33-positive group (64.3% vs. 47.1%, p=0.0164). Compared with those negative for anti-RA33, CTD patients positive for anti-RA33 had significantly higher percentages of SLE-associated antibodies (Figure 1). Higher proportions of SLE patients with a high disease activity (41.7% vs. 24.7%) as well as lower levels of serum complement components (50.0% vs. 27.7%) were observed in the RA33-positive group (Both p<0.05) (Table 1). Furthermore, CTD patients with positive anti-RA33 were more likely to suffer from mucocutaneous (46.4% vs. 33.2%, p=0.0361) and haematological involvement (51.8% vs. 35.6%, p=0.0200) as well as interstitial lung disease (25.0% vs. 11.8%, p=0.0108). ROC analysis revealed an area under the curve value of 0.634 (95% CI: 0.587 to 0.681) for anti-RA33 in the diagnosis of SLE, with a specificity and sensitivity of 92.9% and 13.5%, respectively.ConclusionThis study reveals a significant association between anti-RA33 and the clinical features of CTDs, especially SLE, indicating a potential clinical significance of anti-RA33 in the management of SLE.References[1]Hassfeld W, Steiner G, Graninger W, et al. Autoantibody to the nuclear antigen RA33: a marker for early rheumatoid arthritis.Br J Rheumatol 1993;32(3):199-203.[2]Caporali R, Bugatti S, Bruschi E, et al. Autoantibodies to heterogeneous nuclear ribonucleoproteins. Autoimmunity 2005;38(1):25-32.Figure 1.Association between anti-RA33 and coexistent autoantibodiesAbbreviations: anti-RA33, anti-rheumatoid arthritis 33; anti-U1-snRNP, anti-U1 nuclear ribonucleoproteins; anti-dsDNA, anti-double-stranded DNA; anti-P0, anti-ribosomal P protein; anti-CCP, anti-cyclic citrullinated peptide; AMA-M2, anti-mitochondrial antibody M2 subtype; ACA, anti-cardiolipin antibody; anti-β2GP1-IgG, anti-beta 2 glycoprotein 1 antibody.Table 1.Laboratory characteristics of patients with CTDsParametersRA33-positive (n=56)RA33-negative (n=491)p ValueIgG>18 g/LIgM>2.5 g/LC3<0.80 g/LC4<0.15g/LCRP>5mg/LESR>20mm/hALB<35g/LWBC<4×109/LPLT<100×109/LHb<110g/L(female) or <120g/L(male)32(57.1)6(10.7)28(50.0)29(51.8)19(33.9)40(71.4)20(35.7)16(28.6)7(12.5)21(37.5)161(32.8)41(8.4)136(27.7)173(35.2)149(30.4)261(53.2)156(31.8)111(22.6)35(7.1)122(24.9)0.00060.61220.00110.01900.64670.01040.54880.31880.17950.0531Abbreviations: anti-RA33, anti-rheumatoid arthritis 33; IgG, immunoglobulin G; IgM, immunoglobulin M; C3, complement 3; C4, complement 4; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; ALB, serum albumin; WBC, white blood cell; PLT, platelet; Hb, hemoglobin.Acknowledgements:NIL.Disclosure of InterestsNone Declared.
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Oh, Jung-Min, Christopher C. Venters, Chao Di, Anna Maria Pinto, Lili Wan, Ihab Younis, Zhiqiang Cai et al. "U1 snRNP regulates cancer cell migration and invasion in vitro". Nature Communications 11, n.º 1 (7 de enero de 2020). http://dx.doi.org/10.1038/s41467-019-13993-7.
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AbstractStimulated cells and cancer cells have widespread shortening of mRNA 3’-untranslated regions (3’UTRs) and switches to shorter mRNA isoforms due to usage of more proximal polyadenylation signals (PASs) in introns and last exons. U1 snRNP (U1), vertebrates’ most abundant non-coding (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition with antisense morpholino oligonucleotides (U1 AMO) triggers widespread premature transcription termination and mRNA shortening. Here we show that low U1 AMO doses increase cancer cells’ migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect. In addition to 3’UTR length, numerous transcriptome changes that could contribute to this phenotype are observed, including alternative splicing, and mRNA expression levels of proto-oncogenes and tumor suppressors. These findings reveal an unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states, and suggest U1 as a potential target for their modulation.
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Feng, Qiumin, Zejin Lin, Yanhui Deng, Yi Ran, Rui Yu, Andy Peng Xiang, Congting Ye y Chengguo Yao. "The U1 antisense morpholino oligonucleotide (AMO) disrupts U1 snRNP structure to promote intronic PCPA modification of pre-mRNAs". Journal of Biological Chemistry, mayo de 2023, 104854. http://dx.doi.org/10.1016/j.jbc.2023.104854.
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Tebo, Anne E., Lisa K. Peterson, Melissa R. Snyder y Dorota Lebiedz-Odrobina. "Clinical Significance of Anti–U1 Ribonucleoprotein Antibody Is Analyte Dependent: Implications for Laboratory Reporting, Interpretation, and Interassay Correlations". Archives of Pathology & Laboratory Medicine, 13 de marzo de 2023. http://dx.doi.org/10.5858/arpa.2022-0316-oa.
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Context.— Antibodies to U1 ribonucleoprotein (U1RNP) were first described more than 50 years ago, and although clinically relevant for antinuclear antibody–associated connective tissue disease (ANA-CTD), test results are challenging to interpret. Objective.— To evaluate the impact of anti-U1RNP analyte diversity in the assessment of patients at risk for ANA-CTD. Design.— Two multiplex assays for U1RNP (Sm/RNP and RNP68/A) were used to test serum specimens from consecutive patients (n = 498) under evaluation for CTD in a single academic center. Discrepant specimens were further tested for Sm/RNP antibody by enzyme-linked immunosorbent assay and the BioPlex multiplex assay. Data were evaluated for antibody positivity per analyte and their method of detection, correlations between analytes, and impact on clinical diagnoses through retrospective chart review. Results.— Of the 498 patients tested, 47 (9.4%) were positive in the RNP68/A (BioPlex) and 15 (3.0%) in the Sm/RNP (Theradiag) immunoassays. U1RNP-CTD, other ANA-CTD, and no ANA-CTD were diagnosed in 34% (16 of 47), 12.8% (6 of 47), and 53.2% (25 of 47) of the cases, respectively. The prevalence of antibody by method in patients with U1RNP-CTD was 100.0% (16 of 16), 85.7% (12 of 14), 81.5% (13 of 16), and 87.5% (14 of 16) for RNP68/A, Sm/RNP BioPlex, Sm/RNP Theradiag, and Sm/RNP Inova, respectively. For other ANA-CTD and no ANA-CTD, the highest prevalence was observed with RNP68/A; all others had comparable performance. Conclusions.— In this study, the overall performance characteristics of Sm/RNP antibody assays were comparable; however, the RNP68/A immunoassay was very sensitive but less specific. In the absence of harmonization, reporting the type of U1RNP analyte in clinical testing may be useful in guiding interpretation and interassay correlations.
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Kaur, Jaspreet y Jaswinder Singh. "Comparative Analysis of Line Immunoassay with Immunofluorescence Assay for the Identification of Autoantibodies in Patients with Suspected Systemic Autoimmune Disorders: A Cross-sectional Study". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022. http://dx.doi.org/10.7860/jcdr/2022/53126.16448.
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Introduction: Systemic Autoimmune Diseases (SAD) are the diseases, including Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), sjogren’s syndrome, polymyositis, dermatomyositis, etc. where multiple organs are involved in the presence of a large variety of autoantibodies directed against one’s own immune system at various levels. They are one of the major causes of death and disability in all age groups and are characterized by the presence of Antinuclear Antibodies (ANA) in the blood of patients. Aim: To comparatively evaluate the utility of Line Immunoassay (LIA) with Indirect Immunofluorescence Assay (IIFA) for the detection and identification of ANA in suspected SAD patients. Materials and Methods: The present observational, crosssectional study was conducted on the collected samples of 560 clinically suspected SAD patients attending the Outpatient and Inpatient Departments (Medicine, Paediatrics, Orthopaedics, Dermatology and General Surgery) at Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India (tertiary care hospital), from March 2016 to March 2020. Samples were subjected to ANA testing by IIFA and LIA. All variables anti-dsDNA, anti-Smd1, SSA/Ro and U1 SnRNP, SSA/ Ro, anti Proliferating Cell Nuclear Antigen (PCNA) and PO/RPP, SSB/La, anti CENP-B, Scl70, AMA-M2 and Mi-2 included in the study were presented in the form of percentages. Performance of LIA was reported in terms of sensitivity and specificity at 95% confidence interval. Data was analyzed using Statistical Package for the Social Sciences (SPSS) version 22.0 (Chicago, IL, USA) for windows. Results: Samples of both male (n=229) and female (n=331) patient of age group ranging from 0-90 years with mean age of 38.2 years were studied. Out of 560 samples, 197 (35.17%) patients were found to be ANA positive by IIFA. The LIA was positive in 175 (31.25%) patients. Of these 175 positive patients, 92 (52.57%) had a recognised autoimmune disease with the most common diagnosis was SLE, found in 38 (41.30%). In comparison to IIFA the sensitivity and specificity of LIA was found to be 82.13% and 98.62% respectively with 92.63% accuracy. Conclusion: The combined analysis of IIFA and LIA can be very useful for rapid identification of ANA which strengthen the initiation of treatment at the earliest to reduce disease morbidity and mortality.
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"Низкотемпературные фазовые переходы в полупроводниках Bi2(Sn1-хFeх)2O7 / Удод Л.В., Ситников М.Н., Романова О.Б." Тезисы докладов XIV РОССИЙСКОЙ КОНФЕРЕНЦИИ ПО ФИЗИКЕ ПОЛУПРОВОДНИКОВ «ПОЛУПРОВОДНИКИ-2019», 20 de agosto de 2019, 43. http://dx.doi.org/10.34077/semicond2019-43.
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Пиростаннат висмута Bi2Sn2O7 при комнатной температуре находится в нецентросимметричной моноклинной структуре (α-фазе) с двумя взаимопроникающими оксидными подрешетками общего состава A2B2O6O′, где А и В – катионы металлов. Подрешетка B2O6 состоит из BO6 октаэдров, соединенных вершинами, образуя шестигранные кольца. В подрешетке A2O′ катион А тетраэдрически координирован анионами O′ с линейными связями O′-A−O′. При повышении температуры, Т=412 К, пиростаннат висмута переходит в β-фазу, нецентросимметричную кубическую структуру с удвоенной элементарной ячейкой. Переход α→β имеет ферроэлектрическую природу. С повышением температуры реализуется фазовый β→γ переход второго рода при 953 К в γфазу с кубической структурой. Цель данной работы является установление возможных фазовых переходов при низких температурах, вызванных замещением олова ионами железа. Исследования Bi2(Sn1-xFex)2O7, х=0, 0.1, 0.2 методом ИК-спектроскопии выполнены на ИК Фурье спектрометре ФСМ 2202 со спектральным разрешением 1 см-1 в температурном диапазоне 80- 500 К и интервале частот 400-7000 см-1 на таблетках диаметром 13 мм в матрице KBr. Акустические свойства измерялись на таблетках двумя пьезодатчиками, один из которых являлся генератором, другой приемником ультразвуковых волн. Время прохождения звука составляло τ=10-6 секунд при частоте 5 МГц, толщина образца 0.4 см. Коэффициент затухания звуковой волны рассчитывался по формуле:ߙ ൌ ቀೆభ ೆమ ቁ ௗ , где U1 и U2 амплитуды напряжения, регистрируемых генератором и приемником колебаний, d – толщина таблетки. С ростом концентрации замещающего иона в ИК-спектрах наблюдаются изменения частот фононных мод. При максимальном замещении ионов олова железом (х=0.2) обнаружен низкотемпературный переход типа смещения при 140 К, связанный со смягчением и расщеплением растягивающей моды Bi-Oꞌ колебаний. Этот переход сопровождается сжатием кристаллической решетки и максимумом в температурной зависимости коэффициента теплового расширения. В интервале температур 230-280 К обнаружен ряд фазовых переходов, связанных с поэтапным переходом из моноклинной кристаллической структуры в низшую триклинную, в следствии стохастического распределения ионов железа по образцу. Переход сопровождается смягчением растягивающей моды октаэдров, максимумами в температурной зависимости коэффициента теплового расширения и скорости затухании звука. Замещение ионов олова ионами железа приводит размытому фазовому переходу из моноклинной структуры в тригональную в интервале температур 330-440 К, сопровождающейся смягчением растягивающих мод колебаний кислородных октаэдров и максимумами температурной зависимости затухания звука.
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Islam, Samsul y Nicola Erb. "P030 Multiple autoantibody formation post COVID-19 infection". Rheumatology 63, Supplement_1 (1 de abril de 2024). http://dx.doi.org/10.1093/rheumatology/keae163.072.
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Abstract Background/Aims COVID-19 has been linked to the formation of a number of autoantibodies. This case is an important reminder to clinicians interpreting autoantibody results in conjunction with clinical manifestations. A previously fit 51 year old gentleman, with no prior history of autoimmune disease required admission with respiratory symptoms in April 2020 consistent with COVID-19 infection. His acute respiratory illness was complicated by empyema and left-sided pneumothorax requiring left pleural decortication and adhesiolysis under (VATS). Persistent respiratory symptoms and fatigue lead to investigations for long COVID. Positive antibodies detected were dsDNA 166IU/ml, Proteinase 3 antibodies 20IU/ml, Myeloperoxidase antibodies 32IU/ml, IgG anticardiolipin antibodies 90IU/ml and Glomerular basement membrane antibodies 351 IU/ml. Negative autoantibodies included ANA, RF, aCCP, b2GPI, smooth muscle, AMA and myositis related antibodies. Methods There were no clinical signs or symptoms of inflammatory arthropathy, vasculitis, thrombosis or connective tissue disease. Other investigations included a CT thorax showing no new lung lesions, unremarkable urine dipstick, normal urine ACR, normal US abdomen, CT sinuses and MRI brain. Results Trial course of prednisolone was given therapeutically due to long COVID symptoms. There was no significant impact on symptoms/ autoantibody titres thus steroids were discontinued. The patient was followed closely by the rheumatology team for two years. During that time, the autoantibody levels gradually decreased, and he did not develop clinical signs of autoimmune disease. His long COVID symptoms persisted, and he remains under the long COVID clinical team. Conclusion COVID-19 infection is known to cause an immune response. There have been published cases of positive ANA, U1-snRNP anti-SS-B/La, ANCA, anti-phospholipid and anti-SRP antibody formation following COVID-19 infection. The link between the pathophysiology of COVID-19, autoantibody formation and the role of autoimmunity is still unclear. This man's case was unusual in the number and variety of autoantibodies formed post COVID, this has not been reported in the literature to date. Some of the autoantibodies detected are highly specific for certain conditions, for example anti-GBM antibodies have a high specificity for Goodpasture’s syndrome, thus this case also illustrates the need to interpret positive autoantibodies in the context of clinical findings and history. Disclosure S. Islam: None. N. Erb: None.