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Literatura académica sobre el tema "Tvrm4"

Autor: Grafiati

Publicado: 10 de marzo de 2023

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Artículos de revistas sobre el tema "Tvrm4"

Napoli, Debora, Martina Biagioni, Federico Billeri, Beatrice Di Marco, Noemi Orsini, Elena Novelli y Enrica Strettoi. "Retinal Pigment Epithelium Remodeling in Mouse Models of Retinitis Pigmentosa". International Journal of Molecular Sciences 22, n.º 10 (20 de mayo de 2021): 5381. http://dx.doi.org/10.3390/ijms22105381.

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In retinitis pigmentosa (RP), one of many possible genetic mutations causes rod degeneration, followed by cone secondary death leading to blindness. Accumulating evidence indicates that rod death triggers multiple, non-cell-autonomous processes, which include oxidative stress and inflammation/immune responses, all contributing to cone demise. Inflammation relies on local microglia and recruitment of immune cells, reaching the retina through breakdowns of the inner blood retinal barrier (iBRB). Leakage in the inner retina vasculature suggests similarly altered outer BRB, formed by junctions between retinal pigment epithelium (RPE) cells, which are crucial for retinal homeostasis, immune response, and privilege. We investigated the RPE structural integrity in three models of RP (rd9, rd10, and Tvrm4 mice) by immunostaining for zonula occludens-1 (ZO-1), an essential regulatory component of tight junctions. Quantitative image analysis demonstrated discontinuities in ZO-1 profiles in all mutants, despite different degrees of photoreceptor loss. ZO-1 interruption zones corresponded to leakage of in vivo administered, fluorescent dextran through the choroid-RPE interface, demonstrating barrier dysfunction. Dexamethasone, administered to rd10 mice for rescuing cones, also rescued RPE structure. Thus, previously undetected, stereotyped abnormalities occur in the RPE of RP mice; pharmacological targeting of inflammation supports a feedback loop leading to simultaneous protection of cones and the RPE.

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ABIALA, Moses Akindele, Saurov Jyoti ROY y Lingaraj SAHOO. "EFFECT OF PEG-INDUCED DROUGHT STRESS ON MUNGBEAN PLANTS REVEALED RESISTANT VARIETIES BASED ON LEAF WILTING INDEX AND BIOCHEMICAL MOLECULES". Journal of Plant Development 29, n.º 1 (2022): 117–31. http://dx.doi.org/10.47743/jpd.2022.29.1.900.

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At the early vegetative growth stage, mungbean are mostly affected by drought, and it is also one of the most promising stages that can be used to screen for drought stress tolerance traits in multiple varieties. Therefore, this study utilized polyethylene glycol (PEG-6000) to induce drought stress towards selection of drought tolerance mungbean varieties in their early vegetative growth stage using both hydroponics and soil based systems. In this study, leaf wilting index and responses of biochemical molecules were used as the basic factors to determine the effect of PEG-induced drought stress among the mungbean varieties. Prior to the imposition of drought stress, germination potentials of the varieties were evaluated and all had germination = 60%. Except for Tvr29 and Tvr44, hydroponic system revealed that = 80% of the varieties had = 1 of their leaves significantly (P = 0.05) wilted. The highest LWI were recorded for Tvr49 and Tvr79. Re-evaluation of Tvr29, Tvr44, Tvr49 and Tvr79 using soil, shows that Tvr29 and TVr44 resisted drought stress. The hydrogen peroxide, superoxide radical and malondialdehyde contents decreased in TVr29 and Tvr44, and increased in Tvr49 and Tvr79 in comparison to the control. Tvr29 and Tvr44 had high proline content than Tvr49 and Tvr79. Based on LWI and biochemical molecules, this study revealed that Tvr29 and Tvr44 should be utilized where water deficit is a challenge to mungbean globally.

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Supakulopas, R. y S. M. Tikoo. "The remanent magnetisation recorded in the Chesapeake Bay impact crater, Virginia". Journal of Physics: Conference Series 2145, n.º 1 (1 de diciembre de 2021): 012051. http://dx.doi.org/10.1088/1742-6596/2145/1/012051.

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Abstract During impact events, planetary crusts experience high pressures that can impart rocks with shock remanent magnetisation (SRM) if an ambient magnetic field or demagnetise rocks if a field is absent. If rocks experience substantial impact heating or are pressurised above ~40 GPa (inducing melting and recrystallisation) they may instead record a thermo-viscous remanent magnetisation (TVRM) as they cool below their Curie temperatures. Understanding impact re-magnetisation is crucial for studying terrestrial impact craters, but also unraveling the history of long-lived core dynamo fields on other planetary bodies. In this research we studied impact-related re-magnetisation recorded in natural rock samples from the Chesapeake Bay impact crater, Virginia. As a case study, here we discuss the natural remanent magnetisation (NRM) of two samples of different rock types: a suevite (sample I9-UI, depth 1.40 km beneath the ground) and a schist (sample S32, depth 1.67 km beneath the ground) using thermal and alternating field demagnetisation. The suevite represents a sample that contains material that experience impact remelting, whereas the schist represents an unmelted rock. From the NRM spectra, we found that the sample ITH9-UI was remagnetised by TVRM due to impact-related heating, while the sample STH32 shows the indication of shock deformation of magnetic minerals.

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Won, Jungyeon, Lan Ying Shi, Wanda Hicks, Jieping Wang, Ronald Hurd, Jürgen K. Naggert, Bo Chang y Patsy M. Nishina. "Mouse Model Resources for Vision Research". Journal of Ophthalmology 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/391384.

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The need for mouse models, with their well-developed genetics and similarity to human physiology and anatomy, is clear and their central role in furthering our understanding of human disease is readily apparent in the literature. Mice carrying mutations that alter developmental pathways or cellular function provide model systems for analyzing defects in comparable human disorders and for testing therapeutic strategies. Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function. Two programs, the Eye Mutant Resource and the Translational Vision Research Models, focused on providing such models to the vision research community are described herein. Over 100 mutant lines from the Eye Mutant Resource and 60 mutant lines from the Translational Vision Research Models have been developed. The ocular diseases of the mutant lines include a wide range of phenotypes, including cataracts, retinal dysplasia and degeneration, and abnormal blood vessel formation. The mutations in disease genes have been mapped and in some cases identified by direct sequencing. Here, we report 3 novel alleles ofCrxtvrm65,Rp1tvrm64, andRpe65tvrm148as successful examples of the TVRM program, that closely resemble previously reported knockout models.

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Hashimoto, T., T. Hurst, A. Suzuki, T. Mogi, Y. Yamaya y M. Tamura. "The role of thermal viscous remanent magnetisation (TVRM) in magnetic changes associated with volcanic eruptions: Insights from the 2000 eruption of Mt Usu, Japan". Journal of Volcanology and Geothermal Research 176, n.º 4 (octubre de 2008): 610–16. http://dx.doi.org/10.1016/j.jvolgeores.2008.05.009.

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Piano, Ilaria, Francesca Corsi, Beatrice Polini y Claudia Gargini. "Nutraceutical Molecules Slow Down Retinal Degeneration, in Tvrm4 Mice a Model of Retinitis Pigmentosa, by Genetic Modulation of Anti-oxidant Pathway". Frontiers in Neuroscience 16 (19 de abril de 2022). http://dx.doi.org/10.3389/fnins.2022.868750.

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Rhodopsin (RHO) mutations are responsible for 25–40% of the dominant cases of retinitis pigmentosa (RP) with different severity and progression rates. The Tvrm4 mice, heterozygous for an I307N dominant mutation of RHO, display a normal retinal phenotype when raised in ambient light conditions, but undergo photoreceptor degeneration when briefly exposed to strong white light. Here, The Tvrm4 mice is pre-treated with naringenin 100 mg/kg/die, quercetin 100 mg/kg/die, naringenin 50 + quercercetin 100 mg/kg/die or vehicle dimethyl sulfoxide (DMSO 0.025%) in the drinking water for 35 days. On the 30th day, retinal degeneration was induced by exposure for 1 min to the white light of 12,000 lux intensity, and the treatment was repeated for another 5 days. At the end of the protocol retinal functionality was tested by recording an electroretinogram (ERG). The retinal tissue was collected and was used for further analyses, including immunohistochemically, biochemical, and molecular biology assays. The data obtained show that treatment with nutraceutical molecules is effective in counteracting retinal degeneration by preserving the functionality of photoreceptors and increasing the antioxidant and anti-apoptotic pathways of retinal cells. The present data confirm that nutraceutical molecules are effective in slowing photoreceptor degeneration in a mutation-independent way by modulating the antioxidant response of the retina at the gene expression level.

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Piano, Ilaria, Vanessa D’Antongiovanni, Elena Novelli, Martina Biagioni, Michele Dei Cas, Rita Clara Paroni, Riccardo Ghidoni, Enrica Strettoi y Claudia Gargini. "Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa". Frontiers in Neuroscience 14 (6 de mayo de 2020). http://dx.doi.org/10.3389/fnins.2020.00372.

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Tesis sobre el tema "Tvrm4"

Stefanov, Antonia. "Bipolar cells in Retinitis Pigmentosa - Influence of the age of onset on the nature and severity of remodeling". Doctoral thesis, 2019. http://hdl.handle.net/2158/1151614.

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