Bibliografías temáticas / Trinitrobenzensulfonic acid

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Literatura académica sobre el tema "Trinitrobenzensulfonic acid"

Autor: Grafiati

Publicado: 11 de marzo de 2023

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Artículos de revistas sobre el tema "Trinitrobenzensulfonic acid"

Zhang, Yuanzhi y Guoying Li. "Investigation of the Interaction between Epoxides and Collagen in Epoxy Tanning based on BDDGE Cross-linked Collagen Solution". Journal of the American Leather Chemists Association 115, n.º 8 (3 de agosto de 2020): 279–87. http://dx.doi.org/10.34314/jalca.v115i8.3843.

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To investigate further the interaction between epoxides and collagen in epoxy tanning, collagen solutions (3 mg/ml) cross-linked with various concentrations (0.5–4-wt%) of 1,4-butanediol diglycidyl ether (BDDGE) at low temperature (4ºC), alkaline conditions (pH = 10) were prepared. The sodium dodecyl sulfate–polyacrylamide gel electrophoresis and Fourier transform infrared spectroscopy confirmed the intact triple-helix structure of the cross-linked collagen. With the increasing concentration of BDDGE, the denaturation temperature measured using VP-DSC increased from 42.56 ºC to 44.25ºC and thermogravimetric analysis showed that the decomposition temperature increased from 333.0ºC to 351.8ºC. In addition, the rheology properties such as G¢, G² and ?* were measured with a rotary rheometer using dynamic frequency scanning. The trinitrobenzensulfonic acid method and atomic force microscopy were used to investigate the interaction between collagen and BDDGE. The results indicated that the changes in cross-linked collagen performance were attributed to the transition of collagen aggregation caused by cross-linking. In addition, the transition point of 2-wt% BDDGE was the key node for the formation of a mature cross-linked network and the cross-linking barely increased above that. It is hoped that these findings deepen the understanding of epoxy tanning and provide guidance for the practical use of epoxides in tanning and biomaterials.

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Flacs, Meredith, Maxime Collard, Sabrina Doblas, Magaly Zappa, Dominique Cazals-Hatem, Léon Maggiori, Yves Panis, Xavier Treton y Eric Ogier-Denis. "Preclinical Model of Perianal Fistulizing Crohn’s Disease". Inflammatory Bowel Diseases 26, n.º 5 (27 de noviembre de 2019): 687–96. http://dx.doi.org/10.1093/ibd/izz288.

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Abstract Background Fistulizing anoperineal lesions (FAPLs) are common and severe complications of Crohn’s disease (CD), exposing patients to the risk of anal sphincter alteration and permanent stoma. Due to the limited efficacy of current treatments, identifying new local therapies is mandatory. However, testing new treatments is currently limited because no relevant preclinical model of Crohn’s-like FAPL is available. Thus, a reliable and reproducible experimental model of FAPLs is needed to assess new therapeutic strategies. Methods Twenty-one rats received a rectal enema of 2,4,6-trinitrobenzensulfonic acid (TNBS) to induce proctitis. Seven days later, a transsphincteric fistula tract was created with a surgical thread, instilled with TNBS twice a week until its removal at day 7 (group 1), day 14 (group 2), or day 28 (group 3). In each rat, pelvic MRI was performed just before and 7 days after thread removal. Rats were sacrificed 7 days after thread removal for pathological assessment of the fistula tract. Results The optimal preclinical model was obtained in group 3. In this group, 7 days after thread removal, all animals (9 of 9) had a persistent fistula tract visible on MRI with T2-hypersignal (normalized T2 signal intensity: 2.36 ± 0.39 arbitrary units [a.u.] [2.08–2.81]) and elevation of the apparent diffusion coefficient (1.33 ± 0.16 10-3 millimeter squared per seconds [1.18–1.49]). The pathological examination of the fistula tract revealed acute and chronic inflammation, granulations, fibrosis, epithelialization, and proctitis in the adjacent rectum. Conclusions This reproducible preclinical model could be used to assess the effectiveness of innovative treatments in perianal fistulizing CD.

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Papalois, Apostolos E., Calypso Barbatis, Dimosthenis Chrysikos, Maria Korontzi, Michail Sideris, Theodoros Pittaras, Eleni Triantafyllidi, Alexandros Nomikos y John K. Triantafillidis. "Treatment with Molgramostim (Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor, Rhugm-Csf, Mielogen) and Lenograstim (Granulocyte-Colony Stimulating Factor) Improves Experimental Colitis in Rats". BioMed Research International 2019 (9 de octubre de 2019): 1–8. http://dx.doi.org/10.1155/2019/8298192.

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Background/Aim. Treatment with growth factors could be beneficial in both inflammatory bowel disease and experimental colitis. The aim of this study was to investigate the effect of Colony Stimulating Factor (CSF), and Recombinant Human (rHu) Granulocyte Stimulating Factor (GSF) in experimental colitis in rats. Methods. Experimental colitis was induced in 62 male Wistar rats, divided into 9 groups, using 2,4,6-trinitrobenzensulfonic acid (TNBS). Group 1: Ten rats with colitis without treatment (control group). Euthanasia after 15 days. Group 2: Ten animals with colitis without treatment (control group). Euthanasia after 30 days. Group 3: Six animals with colitis. Immediate treatment with CSF. Euthanasia after 19 days. Group 4: Six animals with colitis. Treatment started 7 days after the induction of colitis. Animals were kept for 19 days. Group 5: Six animals with colitis. Treatment started 2 weeks after the induction of colitis. Group 6: Six animals with colitis, the same as in group 3. Treatment with GSF. Group 7: Six animals with colitis, the same as in group 4. Treatment with GSF. Group 8. Six animals with colitis, the same as in group 5. Treatment with GSF. Group 9: Six animals with colitis. Immediate treatment with prednisolone. Euthanasia after 15 days. Results. CSF and GSF administration significantly improved the histological score (P<0.05) and reduced malondialdehyde contents (P<0.05), compared to control groups in all animals. CSF was superior to GSF and to prednisolone. Conclusion. Administration of both CSF and GSF could significantly improve the histological score and oxidative stress in experimental colitis in rats.

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Ohama, Takashi, Masatoshi Hori, Eiichi Momotani, Yoichiro Iwakura, Fengling Guo, Hiroko Kishi, Sei Kobayashi y Hiroshi Ozaki. "Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-α and causes motility disorders". American Journal of Physiology-Gastrointestinal and Liver Physiology 292, n.º 5 (mayo de 2007): G1429—G1438. http://dx.doi.org/10.1152/ajpgi.00315.2006.

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Motility disorders are frequently observed in intestinal inflammation. We previously reported that in vitro treatment of intestinal smooth muscle tissue with IL-1β decreases the expression of CPI-17, an endogenous inhibitory protein of smooth muscle serine/threonine protein phosphatase, thereby inhibiting contraction. The present study was performed to examine the pathophysiological importance of CPI-17 expression in the motility disorders by using an in vivo model of intestinal inflammation and to define the regulatory mechanism of CPI-17 expression by proinflammatory cytokines. After the induction of acute ileitis with 2,4,6,-trinitrobenzensulfonic acid, CPI-17 expression declined in a time-dependent manner. This decrease in CPI-17 expression was parallel with the reduction of cholinergic agonist-induced contraction of smooth muscle strips and sensitivity of permeabilized smooth muscle fibers to Ca2+. Among the various proinflammatory cytokines tested, TNF-α and IL-1β were observed to directly inhibit CPI-17 expression and contraction in cultured rat intestinal tissue. Moreover, both TNF-α and IL-1β inhibited CPI-17 expression and contraction of smooth muscle tissue isolated from wild-type and IL-1α/β double-knockout mice. However, IL-1β treatment failed to inhibit CPI-17 expression and contraction in TNF-α knockout mice. In β-escin-permeabilized ileal tissues, pretreatment with anti-phosphorylated CPI-17 antibody inhibited the carbachol-induced Ca2+ sensitization in the presence of GTP. These findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-α plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation.

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Tyagi, Rajeev K., Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson y Jeremy A. Goettel. "HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice". Frontiers in Immunology 12 (24 de febrero de 2021). http://dx.doi.org/10.3389/fimmu.2021.630204.

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Regulatory T (Treg) cells are essential to maintain immune homeostasis in the intestine and Treg cell dysfunction is associated with several inflammatory and autoimmune disorders including inflammatory bowel disease (IBD). Efforts using low-dose (LD) interleukin-2 (IL-2) to expand autologous Treg cells show therapeutic efficacy for several inflammatory conditions. Whether LD IL-2 is an effective strategy for treating patients with IBD is unknown. Recently, we demonstrated that LD IL-2 was protective against experimental colitis in immune humanized mice in which human CD4+ T cells were restricted to human leukocyte antigen (HLA). Whether HLA restriction is required for human Treg cells to ameliorate colitis following LD IL-2 therapy has not been demonstrated. Here, we show that treatment with LD IL-2 reduced 2,4,6-trinitrobenzensulfonic acid (TNBS) colitis severity in NOD.PrkdcscidIl2rg-/- (NSG) mice reconstituted with human CD34+ hematopoietic stem cells. These data demonstrate the utility of standard immune humanized NSG mice as a pre-clinical model system to evaluate therapeutics targeting human Treg cells to treat IBD.

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China, Cecilia R., Stephen S. Nyandoro, Joan J. E. Munissi, Mihayo M. Maguta, Michael Meyer y Michaela Schroepfer. "Tanning capacity of Tessmannia burttii extracts: the potential eco-friendly tanning agents for the leather industry". Journal of Leather Science and Engineering 3, n.º 1 (15 de mayo de 2021). http://dx.doi.org/10.1186/s42825-021-00055-2.

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Abstract In the present study, the tannins from stem and root barks of Tessmannia burttii Harms (Caesalpiniaceae), a plant species abundantly growing in Tanzania and other parts of Africa, were investigated for their suitability in hides tanning. Tannin powder was extracted at selected temperatures (30, 50 and 80 °C) and the influence of each temperature on the crosslinking capacity was evaluated. The interaction mechanism between hide powder collagen and the tannins was studied by Differential Scanning Calorimetry (DSC), trinitrobenzensulfonic (TNBS) acid assay and amino acid hydrolysis methods. Extraction temperatures showed low influence on crosslinking capacity of the tannins. However, extract obtained at 50 °C exhibited best performance in terms of gap size between Tonset and Tpeak. The stem bark extract yield was higher than that from the root bark, but both were within the recommended ranges. The tannin content (61%) of T. burttii stem bark extract was above recommended value (10%), whereas its total phenolic content and total flavonoic content were found to be above that of commercial Acacia mearnsii tannin. The study of cross-linking parameters as a function of pH showed cross-linking to occur via a covalent mechanism at the basic amino groups. However, the bonds were not resistant to acid hydrolysis. The observed interaction mechanism indicated that tannins from stem and root barks of T. burttii belong to the condensed tannin, similar to A. mearnsii (black wattle), a commercial tannin source that was used in this study as a reference. Findings from this study depict that T. burttii extracts are auspicious eco-friendly alternative source of vegetable tannins to overcome the use of chromium salts in the leather industry. Graphical abstract

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