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Libros sobre el tema "TRANSLATIONAL BIOMEDICAL SCIENCES"

Autor: Grafiati
Publicado: 11 de marzo de 2023

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1

Intelligent surfaces in biotechnology: Scientific and engineering concepts, enabling technologies, and translation to bio-oriented applications. Hoboken, N.J: John Wiley & Sons, 2012.

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2

Dennis, Cosmatos y Chow Shein-Chung 1955-, eds. Translational medicine: Strategies and statistical methods. Boca Raton: Chapman & Hall/CRC, 2009.

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3

Barker, Richard. The accelerating pace of biomedical advance. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198737780.003.0002.

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Bioscience has progressed exponentially, in scientific advances and enabling technology. From quicker and much cheaper gene sequencing to the emergence of data-mining tools, the last 20 years has been unprecedented in exploitable advances brought by research. We have the tools and insights to trace disease from underlying genetics and epigenetics, through proteins that represent intervention options, to ways to create molecules, diagnostics, and devices based on those insights. The life sciences enterprise, once largely confined to Europe, the USA, and Japan, is now seeing major investment from emerging economies. We should be poised to reap the benefits of this rising tide of research with lives transformed and health systems revolutionized. However, the two million biological science papers published annully results in about 14 000 patents, only 5000 drugs in the pipeline, and a mere 30 or so actual medicines. Translation of life sciences research into usable products is hugely inefficient.
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4

Nanoparticles in Translational Science and Medicine Progress in Molecular Biology Translational Science. Academic Press, 2011.

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5

Martin, Wehling, ed. Translational science in medicine: From bench to bedside. Cambridge: Cambridge University Press, 2009.

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6

Barker, Richard. The gaps in translating biomedical advance into patient benefit. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198737780.003.0003.

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There are no less than five major gaps in translation in the long journey from discovery to practical patient benefit. Insufficient understanding of disease mechanisms (T0), limited skills and motivation in turning lab discoveries into potential products (T1), huge wastage in bringing promising products to market (T2), disappointingly slow adoption by doctors and adherence by patients (T3), and failure to learn from past experience (T4): all cripple the productivity of life sciences. T2 is a particular challenge, especially in medicines, with a high attrition rate in costly clinical trials and increasing difficulties in persuading health technology assessment (HTA) agencies of the added-value of new technologies, combined with HTA differences across countries. Major cultural barriers between academia, practical medicine, and industry make matters worse, as mismatched incentives and mutual suspicion impede collaboration. The net result is poor yield at every stage in the innovation process and therefore very poor translation overall.
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7

David, Robertson y Gordon H. Williams. Clinical and Translational Science: Principles of Human Research. Elsevier Science & Technology Books, 2016.

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8

Clinical and Translational Science: Principles of Human Research. Elsevier Science & Technology Books, 2008.

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9

Barker, Richard. Introduction: The growing innovation gap in life sciences. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198737780.003.0001.

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We live in a world caught up in ever more rapid technological advance. Every week brings new IT products and services. Sectors as diverse as transport, energy, communications, and food are all bringing forward new ways to satisfy human need. However, biomedical innovation remains stubbornly slow and unproductive, as measured by output (benefit to patients) over input (investment). In fact, pharmaceutical innovation follows ‘Eroom’s Law’– an exponential decline in productivity that is the very reverse of Moore’s Law. This is despite very rapid progress in the underlying science. This ‘innovation gap’ puts at risk the very enterprise of life sciences, in which society and investors place so much faith. We need a scientific study of the gaps in translation and radical thinking to bridge them.
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10

Reis, Rui L., J. Miguel Oliveira, Sandra Pina y Julio San Roman. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation. Springer, 2018.

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11

Barker, Richard. Bioscience - Lost in Translation? Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198737780.001.0001.

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Medical innovation as it stands today is fundamentally unsustainable. There is a widening gap between what biomedical research promises and its current impact in terms of patient benefit and health system improvement. This book highlights the global problem, analyses underlying causes, and provides powerful prescriptions for change to close the gap.It contrasts progress in biomedicine with other areas of science and technology, such as information technology, in which there are faster, more reliable returns for society from scientific advance. It questions whether society is right to expect so much from biomedicine and why we have become accustomed to such poor returns.It focuses on four specific ‘gaps in translation’ between bioscience breakthroughs and ultimate patient benefit, and explains how unhelpful mental models and differing perceptions of value, risk, and uncertainty contribute to stifling progress.Specific examples are examined, in which these bottlenecks have prevented promised progress (e.g. antibiotic-resistant infections), and others in which these barriers have been overcome, as a result of patient pressure (e.g. HIV treatment) or a sense of impending crisis (e.g. pandemic influenza).
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12

Singh, Vijai y Rajesh Bhosale. Molecular Biology and Translational Science: Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications. Elsevier Science & Technology, 2021.

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13

Principles of Translational Science in Medicine: From Bench to Bedside. Elsevier Science & Technology Books, 2015.

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14

Wehling, Martin. Principles of Translational Science in Medicine: From Bench to Bedside. Elsevier Science & Technology Books, 2021.

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15

Wehling, Martin. Principles of Translational Science in Medicine: From Bench to Bedside. Elsevier Science & Technology Books, 2015.

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16

Wehling, Martin. Principles of Translational Science in Medicine: From Bench to Bedside. Academic Press, 2021.

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17

Toi, Vo Van, Trung Quoc Le, Hoan Thanh Ngo y Thi-Hiep Nguyen. 7th International Conference on the Development of Biomedical Engineering in Vietnam: Translational Health Science and Technology for Developing Countries. Springer, 2019.

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18

Cosmatos, Dennis y Shein-Chung Chow. Translational Medicine. Taylor & Francis Group, 2019.

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19

Whitesides, George M., Marcus Textor y H. Michelle Grandin. Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications. Wiley & Sons, Incorporated, John, 2012.

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20

Whitesides, George M., Marcus Textor y H. Michelle Grandin. Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications. Wiley & Sons, Incorporated, John, 2012.

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21

Whitesides, George M., Marcus Textor y H. Michelle Grandin. Intelligent Surfaces in Biotechnology: Scientific and Engineering Concepts, Enabling Technologies, and Translation to Bio-Oriented Applications. Wiley & Sons, Incorporated, John, 2012.

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22

Statistics in Translational Medicine (Biostatistics). Chapman & Hall/CRC, 2008.

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23

Cosmatos, Dennis y Shein-Chung Chow. Translational Medicine: Strategies and Statistical Methods. Taylor & Francis Group, 2008.

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24

Cosmatos, Dennis y Shein-Chung Chow. Translational Medicine: Strategies and Statistical Methods. Chapman and Hall/ CRC Biostatistics Series. Taylor & Francis Group, 2009.

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25

Parker, John, Niki Vermeulen y Bart Penders. Collaboration Across Health Research and Medical Care: Healthy Collaboration. Taylor & Francis Group, 2016.

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26

Parker, John, Niki Vermeulen y Bart Penders. Collaboration Across Health Research and Medical Care: Healthy Collaboration. Taylor & Francis Group, 2016.

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27

Parker, John, Niki Vermeulen y Bart Penders. Collaboration Across Health Research and Medical Care: Healthy Collaboration. Taylor & Francis Group, 2016.

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28

Collaboration Across Health Research and Medical Care: Healthy Collaboration. Taylor & Francis Group, 2015.

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29

Parker, John, Niki Vermeulen y Bart Penders. Collaboration Across Health Research and Medical Care: Healthy Collaboration. Taylor & Francis Group, 2016.

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