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Artículos de revistas sobre el tema "Toxicology"

Autor: Grafiati

Publicado: 4 de junio de 2021

Última modificación: 30 de julio de 2024

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1

Hayes, A. Wallace y Darlene Dixon. "Cornerstones of Toxicology". Toxicologic Pathology 45, n.º 1 (enero de 2017): 57–63. http://dx.doi.org/10.1177/0192623316675768.

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The 35th Annual Society of Toxicologic Pathology Symposium, held in June 2016 in San Diego, California, focused on “The Basis and Relevance of Variation in Toxicologic Responses.” In order to review the basic tenants of toxicology, a “broad brush” interactive talk that gave an overview of the Cornerstones of Toxicology was presented. The presentation focused on the historical milestones and perspectives of toxicology and through many scientific graphs, data, and real-life examples covered the three basic principles of toxicology that can be summarized, as dose matters (as does timing), people differ, and things change (related to metabolism and biotransformation).

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2

BABIŃSKA, IZABELLA, JÓZEF SZAREK, MARIUSZ Z. FELSMANN y ANDRZEJ DZIKOWSKI. "Scientific toxicology societies in Europe". Medycyna Weterynaryjna 74, n.º 1 (2018): 5981–2018. http://dx.doi.org/10.21521/mw.5981.

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With the development of toxicology as a science, the second half of the 20th century saw the establishment of scientific societies, such as the International Society of Ecotoxicology and Environmental Safety (SECOTOX), the Federation of European Toxicologists and European Societies of Toxicology (EUROTOX), the Polish Society of Toxicology, and the European Society of Toxicologic Pathology (ESTP). This study describes their development, organizational structure and mission. The scope of their interest, in addition to toxicology, also includes ecotoxicology, which protects the natural environment and public health..

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3

Hukkanen, Renee R., Noel Dybdal, Niraj Tripathi, Patricia V. Turner y Sean P. Troth. "Scientific and Regulatory Policy Committee Points to Consider*: The Toxicologic Pathologist’s Role in the 3Rs". Toxicologic Pathology 47, n.º 7 (octubre de 2019): 789–98. http://dx.doi.org/10.1177/0192623319859261.

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Pathologists are trained medical professionals with special expertise in diagnostics, research, and pathophysiology. In these roles, pathologists are well qualified and positioned to engage in conversations about animal use replacement, reduction, and refinement (3Rs), thereby championing the guiding principles of the 3Rs. In particular, toxicology or nonclinical safety assessment is an important area where the discipline of toxicologic pathology can have a critical role in adopting 3Rs principles. As such, a working group of the Society of Toxicologic Pathology Scientific and Regulatory Policy Committee was formed to investigate and summarize some of the areas where veterinary pathologists working in the field of toxicology can increase involvement and impact on 3Rs. This “Points to Consider” publication provides an overview of areas within toxicology where the veterinary pathologist’s perspective may maximize animal value, including refinement of study design, optimizing sample collection, the development of 3Rs focused regulatory policy, and humane end point determination.[Box: see text]

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4

Cohen, Samuel M., Wanda M. Haschek-Hock y Carl Alden. "Obituary: Dr Gordon Charles Hard (1931-2021)". Toxicologic Pathology 50, n.º 2 (8 de enero de 2022): 164–65. http://dx.doi.org/10.1177/01926233211068853.

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Dr Gordon Hard, of Tairua, New Zealand, a preeminent international toxicology thought leader and international consultant in toxicologic pathology of the kidney, passed on November 22, 2021. He was a key player in shaping and developing the global field of toxicologic pathology and the role of toxicologic pathology in risk assessment of environmental chemicals and pharmaceuticals.

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5

Bolon (Chair), Brad, Erio Barale-Thomas, Alys Bradley, Robert A. Ettlin, Carla A. S. Franchi, Catherine George, Anna Maria Giusti et al. "International Recommendations for Training Future Toxicologic Pathologists Participating in Regulatory-type, Nonclinical Toxicity Studies". Toxicologic Pathology 38, n.º 6 (17 de agosto de 2010): 984–92. http://dx.doi.org/10.1177/0192623310378137.

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The International Federation of Societies of Toxicologic Pathologists (IFSTP) proposes a common global framework for training future toxicologic pathologists who will support regulatory-type, nonclinical toxicology studies. Optimally, trainees should undertake a scientific curriculum of at least five years at an accredited institution leading to a clinical degree (veterinary medicine or medicine). Trainees should then obtain four or more years of intensive pathology practice during a residency and/or on-the-job “apprenticeship,” at least two years of which must be focused on regulatory-type toxicologic pathology topics. Possession of a recognized pathology qualification (i.e., certification) is highly recommended. A nonclinical pathway (e.g., a graduate degree in medical biology or pathology) may be possible if medically trained pathologists are scarce, but this option is not optimal. Regular, lifelong continuing education (peer review of nonclinical studies, professional meetings, reading, short courses) will be necessary to maintain and enhance one’s understanding of current toxicologic pathology knowledge, skills, and tools. This framework should provide a rigorous yet flexible way to reliably train future toxicologic pathologists to generate, interpret, integrate, and communicate data in regulatory-type, nonclinical toxicology studies.

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6

Maronpot, Robert R., Abraham Nyska, Sean P. Troth, Kathleen Gabrielson, Polina Sysa-Shah, Vyacheslav Kalchenko, Yuri Kuznetsov et al. "Regulatory Forum Opinion Piece*: Imaging Applications in Toxicologic Pathology—Recommendations for Use in Regulated Nonclinical Toxicity Studies". Toxicologic Pathology 45, n.º 4 (junio de 2017): 444–71. http://dx.doi.org/10.1177/0192623317710014.

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Available imaging systems for use in preclinical toxicology studies increasingly show utility as important tools in the toxicologic pathologist’s armamentarium, permit longitudinal evaluation of functional and morphological changes in tissues, and provide important information such as organ and lesion volume not obtained by conventional toxicology study parameters. Representative examples of practical imaging applications in toxicology research and preclinical studies are presented for ultrasound, positron emission tomography/single-photon emission computed tomography, optical, magnetic resonance imaging, and matrix-assisted laser desorption ionization—imaging mass spectrometry imaging. Some of the challenges for making imaging systems good laboratory practice–compliant for regulatory submission are presented. Use of imaging data on a case-by-case basis as part of safety evaluation in regulatory submissions is encouraged.

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7

Troth, Sean P., Nancy E. Everds, William Siska, Brian Knight, Martin Lamb y Julie Hutt. "Scientific and Regulatory Policy Committee Points to Consider: Data Visualization for Clinical and Anatomic Pathologists". Toxicologic Pathology 46, n.º 5 (29 de mayo de 2018): 476–87. http://dx.doi.org/10.1177/0192623318778733.

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Assessment and communication of toxicology data are fundamental components of the work performed by veterinary anatomic and clinical pathologists involved in toxicology research. In recent years, there has been an evolution in the number and variety of software tools designed to facilitate the evaluation and presentation of toxicity study data. A working group of the Society of Toxicologic Pathology Scientific and Regulatory Policy Committee reviewed existing and emerging visualization technologies. This Points to Consider article reviews some of the currently available data visualization options, describes the utility of different types of graphical displays, and explores potential areas of controversy and ambiguity encountered with the use of these tools.

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8

Bhat, Sagar S. y Srinivasa Gopala Rao. "Toxicology-the blind spot". Asian Pacific Journal of Health Sciences 5, n.º 3 (julio de 2018): 225–32. http://dx.doi.org/10.21276/apjhs.2018.5.3.31.

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9

Hobson, David W., Stephen M. Roberts, Anna A. Shvedova, David B. Warheit, Georgia K. Hinkley y Robin C. Guy. "Applied Nanotoxicology". International Journal of Toxicology 35, n.º 1 (enero de 2016): 5–16. http://dx.doi.org/10.1177/1091581816628484.

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Nanomaterials, including nanoparticles and nanoobjects, are being incorporated into everyday products at an increasing rate. These products include consumer products of interest to toxicologists such as pharmaceuticals, cosmetics, food, food packaging, household products, and so on. The manufacturing of products containing or utilizing nanomaterials in their composition may also present potential toxicologic concerns in the workplace. The molecular complexity and composition of these nanomaterials are ever increasing, and the means and methods being applied to characterize and perform useful toxicologic assessments are rapidly advancing. This article includes presentations by experienced toxicologists in the nanotoxicology community who are focused on the applied aspect of the discipline toward supporting state of the art toxicologic assessments for food products and packaging, pharmaceuticals and medical devices, inhaled nanoparticle and gastrointestinal exposures, and addressing occupational safety and health issues and concerns. This symposium overview article summarizes 5 talks that were presented at the 35th Annual meeting of the American College of Toxicology on the subject of “Applied Nanotechnology.”

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10

Lamb, J. C., M. D. Ross y R. E. Chapin. "Experimental Methods for Studying Male Reproductive Function in Standard Toxicology Studies". Journal of the American College of Toxicology 5, n.º 4 (julio de 1986): 225–34. http://dx.doi.org/10.3109/10915818609140747.

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Indicators of insult to the male reproductive system can be incorporated into standard toxicology studies so that the assessment of reproductive toxicity does not interfere with the general toxicologic evaluation. This can include assessment of testicular spermatids, or sperm from the epididymis, or vas deferens, or assessment of semen collected from the female reproductive tract postcoitally. Endpoints evaluated may include sperm count, motility, or sperm head morphology. Testicular morphology also may be evaluated by various improved histologic techniques. For example, when testes are immersion-fixed in formalin, testicular morphology is significantly improved by embedding the tissue in the water-soluble plastic glycol methacrylate (GMA) rather than paraffin. These approaches to male reproductive toxicology are cost-effective and reduce the number of animals required for pilot or survey studies for testicular toxicity. They can provide useful data on male reproductive function.

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11

Rico Martínez, Roberto. "An Introduction to Aquatic Toxicology [Introducción a la Toxicología acuática]". Investigación y Ciencia de la Universidad Autónoma de Aguascalientes, n.º 72 (29 de noviembre de 2017): 131–32. http://dx.doi.org/10.33064/iycuaa201772231.

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12

Kuper, C. Frieke y Maarten C. Bosland. "Victor Feron, A life dedicated to toxicology and toxicologic pathology". Food and Chemical Toxicology 125 (marzo de 2019): 438. http://dx.doi.org/10.1016/j.fct.2019.01.006.

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13

Dagli, Maria L. Z., Arun Pandiri, Jeff Wolf, Sibylle Groeters y Wanda M. Haschek-Hock. "Global Perspective on Careers in Environmental Toxicologic Pathology: The 2019 Society of Toxicologic Pathology Annual Symposium Lunchtime Career Development Session". Toxicologic Pathology 47, n.º 8 (25 de septiembre de 2019): 1088–95. http://dx.doi.org/10.1177/0192623319877859.

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A wide range of career options is available globally in the environmental toxicologic pathology (ETP) arena including academia, government, contract research organizations, and the agrichemical/chemical industry. This small and specialized subset of toxicologic pathologists addresses the effects of contaminants and pollutants on human, animal, and ecological health (One Health). Veterinary students and pathology trainees are primarily exposed to diagnostic pathology and often have limited exposure to toxicologic pathology and even less so to the issues and opportunities in environmental toxicology. The speakers provided a brief overview of global opportunities in their work sector and personal perspectives of their careers in ETP. The following panel discussion provided an opportunity to discuss issues related to careers in this specialty.

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14

Zimmerman, Janice L. "Toxicology". Critical Care Clinics 37, n.º 3 (julio de 2021): i. http://dx.doi.org/10.1016/s0749-0704(21)00029-4.

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15

Mote, Pat. "Toxicology". American Biology Teacher 65, n.º 9 (1 de noviembre de 2003): 714–15. http://dx.doi.org/10.2307/4451599.

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16

Zurita, Antonio Zarzuelo. "Toxicology". Pharmaceuticals, Policy and Law 17, n.º 1,2 (2015): 101–16. http://dx.doi.org/10.3233/ppl-140404.

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17

Baars, Bert-Jan. "Toxicology". Land Contamination & Reclamation 14, n.º 4 (1 de octubre de 2006): 775–91. http://dx.doi.org/10.2462/09670513.696.

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18

Tabatabai, M. A. "Toxicology". Journal of Environmental Quality 19, n.º 2 (abril de 1990): 349–50. http://dx.doi.org/10.2134/jeq1990.00472425001900020026x.

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19

Editors, The. "Toxicology". Emergency Care Journal 6, n.º 4 (13 de diciembre de 2010): 30. http://dx.doi.org/10.4081/ecj.2010.4.30.

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20

Poppenga, Robert H. y Petra A. Volmer. "Toxicology". Veterinary Clinics of North America: Small Animal Practice 32, n.º 2 (marzo de 2002): 307–8. http://dx.doi.org/10.1016/s0195-5616(01)00002-x.

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21

Cicmanec, J. L. "Toxicology". Toxicology 119, n.º 3 (mayo de 1997): 239. http://dx.doi.org/10.1016/s0300-483x(97)00051-6.

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22

Warshawsky, David, William Barkley, Marian L. Miller, Kathy Ladow y anastasia Andringa. "Toxicology". Toxicology 96, n.º 3 (febrero de 1995): 239–40. http://dx.doi.org/10.1016/s0300-483x(99)80002-x.

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23

Ensley, Steve y Timothy J. Evans. "Toxicology". Veterinary Clinics of North America: Food Animal Practice 36, n.º 3 (noviembre de 2020): i. http://dx.doi.org/10.1016/s0749-0720(20)30063-3.

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24

Adoga, GI. "Toxicology". Biochemical Education 13, n.º 1 (enero de 1985): 43. http://dx.doi.org/10.1016/0307-4412(85)90152-9.

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25

Miller, Anita C. K., Lori D. Dwyer-Nield y Alvin M. Malkinson. "Toxicology". Toxicology 103, n.º 1 (noviembre de 1995): 75. http://dx.doi.org/10.1016/0300-483x(95)99371-i.

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26

Lodge, James P. "Toxicology". Atmospheric Environment (1967) 23, n.º 10 (enero de 1989): 2339. http://dx.doi.org/10.1016/0004-6981(89)90203-5.

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27

Netter, K. J. "Toxicology". Toxicology 61, n.º 2 (abril de 1990): 212–13. http://dx.doi.org/10.1016/0300-483x(90)90024-b.

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28

Oehme, Frederick W. "Toxicology". Toxicology Letters 87, n.º 2-3 (octubre de 1996): 167–68. http://dx.doi.org/10.1016/0378-4274(96)03769-1.

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29

Fawcett, H. H. "Toxicology". Journal of Hazardous Materials 22, n.º 3 (diciembre de 1989): 417. http://dx.doi.org/10.1016/0304-3894(89)80011-1.

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30

Kruse, James A. "Toxicology". Critical Care Clinics 28, n.º 4 (octubre de 2012): xi—xii. http://dx.doi.org/10.1016/j.ccc.2012.08.001.

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31

WADA, OSAMU. "ECO-BIO-TOXICOLOGY AND PREVENTIVE TOXICOLOGY". Journal of Toxicological Sciences 16, SupplementII (1991): 3–12. http://dx.doi.org/10.2131/jts.16.supplementii_3.

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32

Netter, K. J. "Reproductive toxicology (target organ toxicology series)". Toxicology 38, n.º 2 (febrero de 1986): 249–50. http://dx.doi.org/10.1016/0300-483x(86)90126-5.

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33

Morais, Rutiléa Mendes de, Márcia Martins Ornelas, Lucas Da Conceição Santos y Benedito Gonçalves Eugenio. "O Conhecimento do Conteúdo de Licenciandas de Pedagogia Sobre as Plantas Medicinais e sua Toxicologia". Revista de Ensino, Educação e Ciências Humanas 24, n.º 3 (29 de noviembre de 2023): 462–67. http://dx.doi.org/10.17921/2447-8733.2023v24n3p462-467.

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Este artigo apresenta os resultados de uma pesquisa que objetivou compreender quais os conhecimentos que as licenciandas do curso de Pedagogia da Universidade Estadual do Sudoeste da Bahia (UESB) têm sobre o conteúdo das plantas medicinais e a toxicologia das plantas medicinais. Para obtenção dos dados, contamos com questionários e entrevista semiestruturada por meio do CoRe (Representação do Conteúdo). Para o processo de análise consideramos três categorias, a saber: 1) Conhecimentos das licenciandas sobre as plantas medicinais; 2) Conhecimentos das licenciandas sobre a intoxicação por plantas medicinais; 3) Conhecimentos das licenciandas acerca da importância do ensino das plantas medicinais na escola. Os resultados apontam que as licenciandas apresentam conhecimentos acerca dos benefícios das plantas medicinais. Entretanto, no que se refere aos seus efeitos colaterais e toxicologia das mesmas as licenciandas não apresentaram conhecimentos satisfatórios. Mediante esses resultados, algumas considerações são tecidas no tocante à formação do pedagogo para o ensino de ciências nos anos iniciais do ensino fundamental e o seu âmbito de formação principal, o curso de Pedagogia. Palavras-chave: Formação de Professores. Plantas na Escola. Toxicologia das Plantas. Abstract The present work aims to understand what knowledge the graduates of the Pedagogy course at UESB have about the content of medicinal plants and the toxicology of medicinal plants. To obtain the data, we used questionnaires and semi-structured interviews through CoRe. For the analysis process, we considered three categories, namely: 1) Licensee's knowledge about medicinal plants; 2) Licensee's knowledge about intoxication by medicinal plants; 3) Knowledge of the undergraduates about the importance of teaching medicinal plants at school. The results show that the licensees have knowledge about the benefits of medicinal plants. However, with regard to side effects and toxicology of medicinal plants, the licensees did not present satisfactory knowledge. Based on these results, some considerations are made regarding the formation of the pedagogue for the teaching of science in the early years of elementary school and its main training scope, the pedagogy course. Key words: Teacher Training. Medicinal Plants. Toxicology

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34

Harrill, Alison H., Jonathan G. Moggs, Karissa K. Adkins, Hellmut G. Augustin, Robert C. Johnson y Michael W. Leach. "A Synopsis of the “Influence of Epigenetics, Genetics, and Immunology” Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium". Toxicologic Pathology 45, n.º 1 (5 de octubre de 2016): 114–18. http://dx.doi.org/10.1177/0192623316670781.

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The overarching theme of the 2016 Society of Toxicology Pathology’s Annual Symposium was “The Basis and Relevance of Variation in Toxicologic Responses.” Session 4 focused on genetic variation as a potential source for variability in toxicologic responses within nonclinical toxicity studies and further explored how knowledge of genetic traits might enable targeted prospective and retrospective studies in drug development and human health risk assessment. In this session, the influence of both genetic sequence variation and epigenetic modifications on toxicologic responses and their implications for understanding risk were explored. In this overview, the presentations in this session will be summarized, with a goal of exploring the ramifications of genetic and epigenetic variability within and across species for toxicity studies and disseminating information regarding novel tools to harness this variability to advance understanding of toxicologic responses across populations.

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35

Christian, Mildred S. "History of the American College of Toxicology (ACT)". International Journal of Toxicology 23, n.º 5 (septiembre de 2004): 285–99. http://dx.doi.org/10.1080/10915810490517054.

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This manuscript is one of two written to celebrate the 25th Anniversary of the American College of Toxicology (ACT). This history of ACT describes its evolution from an entrepreneurial, risk taking model to a conservative business model, fully accepted in the scientific community. ACT started with a small group of scientists who were dissatisfied with the relatively narrow approach to full membership then taken by the Society of Toxicology (SOT). They were excited by new research and collaborative opportunities resulting from an enhanced public awareness of the impact of chemicals on the environment and emerging new methodologies to evaluate human risks of exposure to be chemicals and pharmaceuticals. These toxicologists, many of whom were from industry and government, rather than academia, were tired of being considered socond class citizens and envisioned more open and cross-disciplined approaches. They favored balanced input by academia, industry and government in the overall toxicologic evaluation and risk assessment process. The history of the founding and early development of ACT, as well as the College’s growth and eventual acceptance into the scientific community, including its impact on the status quo during the Society’s first 25 years, are told by its successive presidents.

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36

Patočka, Jiří, Zdeněk Hon, Petr Procházka y Kamil Kuča. "Toxicology and environmental toxicology of herbicide triclopyr". Kontakt 13, n.º 2 (20 de junio de 2011): 242–49. http://dx.doi.org/10.32725/kont.2011.029.

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37

Boué, S., B. Hardy, W. Hayes, V. Belcastro, T. Exner, J. Dokler, J. Hoeng y M. C. Peitsch. "Sharing systems toxicology data for inhalation toxicology". Toxicology Letters 259 (octubre de 2016): S141—S142. http://dx.doi.org/10.1016/j.toxlet.2016.07.598.

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38

Manzetti, Sergio. "Quantum toxicology—A potential perspective in toxicology?" Toxicology 288, n.º 1-3 (octubre de 2011): 56–57. http://dx.doi.org/10.1016/j.tox.2011.06.015.

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Gussow, Leon. "Toxicology Rounds: Kitchen Toxicology: Nutmeg (the Hallucinogen)". Emergency Medicine News 33, n.º 5 (mayo de 2011): 16. http://dx.doi.org/10.1097/01.eem.0000398222.48791.3d.

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40

Robinson, J. Paul y R. W. Pfeifer. "New Technologies for Use in Toxicology Studies: Monitoring the Effects of Xenobiotics on Immune Function". Journal of the American College of Toxicology 9, n.º 3 (mayo de 1990): 303–17. http://dx.doi.org/10.3109/10915819009078741.

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New developments in flow cytometry are now being applied in toxicology studies. There are several reasons for using this technology. First, techniques are well characterized to measure functional parameters of single cells. Such measurements can be directly related to perturbations by xenobiotics, cell-mediated immune responses, or trauma. Second, there is a clear indication for movement toward in vitro systems as highly objective assessments of toxicologic interactions. By measuring specific cell functions at the single cell level, it is possible to define a range of normal responses. More importantly, a multiparametric analysis can be performed with flow cytometry and parameters can be directly related to one another. Furthermore, kinetic measurements can be made, providing vital clues to the mechanisms of actions of drugs or chemicals on functions of specific cell populations. Major advantages of this approach are that studies can be performed on very small volumes of blood, body fluid, or cell culture lines and it is not necessary to isolate pure populations of cells to perform these assays. We believe that this alternative approach in toxicology will provide valuable information unobtainable by traditional means.

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41

Rashan, Luay, Thomas Efferth, Muhammed Bishir, Muhammed Bishir, Musthafa Mohamed Essa, Saravana Babu Chidambaram y M. Walid Qoronfleh. "Acute, genetic, and target organ toxicity profiling of Frankincense essential oil from Boswellia sacra in zebrafish (Danio rerio)". Archives of Clinical Toxicology 5, n.º 1 (9 de mayo de 2023): 12–21. http://dx.doi.org/10.46439/toxicology.5.020.

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Frankincense oil is widely used across the globe for various therapeutic implications. However, the potential toxicity profile of Frankincense oil has not been well explored. The present study is a debut attempt to study the organ-specific (cardiac, hepatic, and neuromuscular) toxicity profile of Frankincense essential oil from Boswellia sacra using the zebrafish embryo model. The results revealed a “no observed effect concentration” (NOEC) dose of Frankincense oil of 300 µg/ml. Signs of cardiac toxicity were not observed if the zebrafish embryos were incubated with Frankincense oil (100 µg/ml). In addition, signs of genotoxicity were also not observed at the same concentration. Similarly, neuromuscular toxicity evaluated by the locomotor activity in the presence of light and hepatic toxicity measured by liver size, yolk retention, and steatosis were not found. Despite the absence of toxic effects of Frankincense oil on zebrafish embryo survival, it should be further investigated to assess if the prolonged administration of Frankincense oil in higher vertebrates might induce potential toxic effects.

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42

Saravanan, Deepak, Shaik Mohammad Rafi y Monisha Mohan. "Identification of novel Bioactivities from Bee venom to target TNF-α for cancer therapy". Archives of Clinical Toxicology 5, n.º 1 (9 de mayo de 2023): 22–27. http://dx.doi.org/10.46439/toxicology.5.021.

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Cancer is one of the major public health problems globally which arises due to uncontrolled cellular proliferation. Tumor necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. Currently, the venom from various sources have been widely used in the treatment of cancer. The bioactive present in bee venom has been reported to have potential antimicrobial, anti-inflammatory, and anticancer activity which has drawn the attention to identify the novel inhibitor against TNF-α. Bee venom has been reported to target ovarian, breast, prostate and malignant hepatocellular carcinoma. TNF-α is involved in the maintenance and homeostasis of the immune system, inflammation, and host defense. The oncogenic protein TNF-α plays a critical role in the development of various cancers including renal, lung, liver, prostate, bladder, and breast cancer. TNF-α enhances cancer cell growth, proliferation, invasion, and metastasis, as well as tumor angiogenesis. Due to the high prevalence and mortality, TNF-α associated cancers have remained a significant health problem globally. TNF acts biologically by activating certain signaling pathways such as nuclear factor κB (NF-κB) and c-Jun N-terminal kinase (JNK). Various toxins are being studied as alternatives for cancer treatments, and bee venom and its active components are drawing attention as potential anticancer agents. The present study identifies novel anticancer peptides that target the oncoprotein against life-threatening cancer. Docking calculations indicate that anticancer peptides, namely Melittin, Phospholipase A2, Tertiapin, and Hyaluronidase bind TNF-α respectively with the lowest binding affinity. Interestingly, Mast cell degranulating (MCD) and Apamin have the highest binding affinity with TNF-α in comparison with the above four peptides. The two lead compounds namely MCD and Apamin have the highest docking score -1253.4 and -1067.8 respectively. The present study reveals that the bee venom peptides namely MCD and Apamin interact with TNF-α associated cancer for targeted therapy of cancer. These predicted anticancer peptides are valuable candidates for in vitro or in vivo peptide therapeutic drug studies against the TNF-α associated cancers.

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Mensah, Kwesi Boadu. "Conceptualizing the use of the clinical index of liver fibrosis, FIB-4 index, in in vivo preclinical toxicological studies". Archives of Clinical Toxicology 5, n.º 1 (23 de agosto de 2023): 28–39. http://dx.doi.org/10.46439/toxicology.5.022.

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Patra, Ambika Prasad. "Recent advances in nanotoxicology technology in treating delayed poisoning cases". Archives of Clinical Toxicology 6, n.º 1 (2 de abril de 2024): 1–3. http://dx.doi.org/10.46439/toxicology.6.025.

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45

Addissouky, Tamer A., Ibrahim El Tantawy El Sayed, Majeed M. A. Ali y Yuliang Wang. "Towards personalized care: Unraveling the genomic and molecular basis of sepsisinduced respiratory complications". Archives of Clinical Toxicology 6, n.º 1 (2 de abril de 2024): 4–15. http://dx.doi.org/10.46439/toxicology.6.026.

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46

Gazerro, Chiara y Carla Landolfi. "Valproate, Topiramate, and emerging neurodevelopmental concerns". Archives of Clinical Toxicology 6, n.º 1 (2 de abril de 2024): 16–18. http://dx.doi.org/10.46439/toxicology.6.027.

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47

Saghir, Shakil A., Dileep K. Rohra, Riyadh S. Almalki y Rais Ansari. "The burgeoning liver disease at the interface of metabolic syndrome and type 2 diabetes: Nonalcoholic fatty liver disease (NAFLD)". Archives of Clinical Toxicology 6, n.º 1 (29 de abril de 2024): 19–20. http://dx.doi.org/10.46439/toxicology.6.028.

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48

Lewis, Kara D. y Michael Falk. "Toxicological assessment of chondroitin sulfate oligosaccharide". Archives of Clinical Toxicology 5, n.º 1 (21 de diciembre de 2023): 40–51. http://dx.doi.org/10.46439/toxicology.5.023.

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Toxicology studies were conducted to evaluate the safety of chondroitin sulfate oligosaccharide (CSO) produced by the enzymatic hydrolysis of shark cartilage by a bacterial lyase. Although the safety of chondroitin sulfate, which is used as a dietary supplement, has been investigated, no safety studies have been conducted on CSO. CSO was evaluated in bacterial reverse mutagenesis, mammalian cell gene mutation using mouse lymphoma cells, in vivo mammalian erythrocyte micronucleus assays, and a ninety-day repeated dose oral toxicity study in rats. The study showed that CSO was not genotoxic. The No Observed Adverse Effect Level (NOAEL) was determined to be 4,000 mg/kg bw/day, the highest dose tested.

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49

Petkov, Daniel, Daniel J. Patrick, Petrina Rogerson, David Rehagen, Gayle Hennig, Alys Bradley, Paul Howroyd et al. "Idiopathic Aneurysms of the Ascending Aorta in the Mouse and Rat". Toxicologic Pathology 50, n.º 1 (2 de diciembre de 2021): 4–12. http://dx.doi.org/10.1177/01926233211056872.

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Aneurysms of the ascending aorta, unrelated to xenobiotic administration, are described in 5 rats and 2 mice in nonclinical safety studies conducted at Charles River Laboratories (CRL) sites over the past 10 years. The most prominent microscopic finding was focal dilation with disruption of the wall of the ascending aorta with chronic adventitial inflammation or fibroplasia. The pathogenesis of this finding is unknown. There were no associated macroscopic findings, clinical abnormalities, or vascular lesions elsewhere. The results of a search of historical control data from toxicology studies of 1 day to 72 weeks’ duration performed at CRL for aortic findings from 5900 mice and 23,662 rats are also reported. Aortic lesions are uncommon in mice and rats used in nonclinical safety studies, but toxicologic pathologists should be aware that aneurysms of the ascending aorta with fibroplasia and inflammation in the aortic wall and adventitia may occur spontaneously or iatrogenically, as they have the potential to impact interpretation in toxicology studies.

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50

Derosa, Christopher T., Yee-Wan Stevens, Jewell D. Wilson, Adedamola A. Ademoyero, Sharunda D. Buchanan, William Cibulas, Penny J. Duerksen-Hughes et al. "The Agency for Toxic Substances and Disease Registry's Role in Development and Application of Biomarkers in Public Health Practice". Toxicology and Industrial Health 9, n.º 6 (noviembre de 1993): 979–94. http://dx.doi.org/10.1177/074823379300900601.

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717 An overview of the Agency for Toxic Substances and Disease Registry's (ATSDR) biomarker program is presented in the context of the paradigm for biomarkers developed by the National Research Council (NRC, 1987, 1991). The status and projected utility of four biomarker studies conducted by NRC and sponsored by ATSDR, the Environmental Protection Agency (EPA), and the National Institute of Environmental Health Sciences (NIEHS) are discussed. These studies include a review of relevant research on biomarkers for specific toxicologic end points, including reproductive toxicology, pulmonary toxicology, neurotoxicology, and immunotoxicology. Also, the scope of related research on exposure characterization being conducted by the ATSDR-sponsored research program at Rutgers University is reviewed. The potential impact of biomarkers on public health assessments and on the range of ATSDR programs is described. Specifically, the role of biomarkers in dose reconstruction, in ATSDR's health studies program, and in the emerging field of molecular epidemiology is reviewed. In addition, future directions and research needs are addressed.

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