Literatura académica sobre el tema "Toxicodynamie"
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Artículos de revistas sobre el tema "Toxicodynamie"
Kasteel, Emma E. J., Sandra M. Nijmeijer, Keyvin Darney, Leonie S. Lautz, Jean Lou C. M. Dorne, Nynke I. Kramer y Remco H. S. Westerink. "Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics". Archives of Toxicology 94, n.º 12 (10 de octubre de 2020): 4055–65. http://dx.doi.org/10.1007/s00204-020-02927-8.
Texto completoBoak, Lauren M., Craig R. Rayner, M. Lindsay Grayson, David L. Paterson, Denis Spelman, Sharmila Khumra, Blair Capitano et al. "Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid". Antimicrobial Agents and Chemotherapy 58, n.º 4 (10 de febrero de 2014): 2334–43. http://dx.doi.org/10.1128/aac.01885-13.
Texto completoBlanchette, Alexander D., Sarah D. Burnett, Fabian A. Grimm, Ivan Rusyn y Weihsueh A. Chiu. "A Bayesian Method for Population-wide Cardiotoxicity Hazard and Risk Characterization Using an In Vitro Human Model". Toxicological Sciences 178, n.º 2 (20 de octubre de 2020): 391–403. http://dx.doi.org/10.1093/toxsci/kfaa151.
Texto completoKavlock, Robert J. y Gabriel L. Plaa. "Session summary: toxicodynamic interactive mechanisms". Toxicology 105, n.º 2-3 (diciembre de 1995): 235–36. http://dx.doi.org/10.1016/0300-483x(95)03218-5.
Texto completoAshauer, Roman y Colin Brown. "TOXICODYNAMIC ASSUMPTIONS IN ECOTOXICOLOGICAL HAZARD MODELS". Environmental Toxicology and Chemistry preprint, n.º 2008 (2007): 1. http://dx.doi.org/10.1897/07-642.
Texto completoAshauer, Roman y Colin D. Brown. "TOXICODYNAMIC ASSUMPTIONS IN ECOTOXICOLOGICAL HAZARD MODELS". Environmental Toxicology and Chemistry 27, n.º 8 (2008): 1817. http://dx.doi.org/10.1897/07-642.1.
Texto completoSerkova, Natalie J. y Uwe Christians. "Biomarkers for Toxicodynamic Monitoring of Immunosuppressants". Therapeutic Drug Monitoring 27, n.º 6 (diciembre de 2005): 733–37. http://dx.doi.org/10.1097/01.ftd.0000179846.30342.65.
Texto completoGots, Ronald E. y Suellen W. Pirages. "Multiple Chemical Sensitivities: Psychogenic or Toxicodynamic Origins". International Journal of Toxicology 18, n.º 6 (noviembre de 1999): 393–400. http://dx.doi.org/10.1080/109158199225107.
Texto completoReeves, Andrew L. "Beryllium: Toxicological Research of the Last Decade". Journal of the American College of Toxicology 8, n.º 7 (diciembre de 1989): 1307–13. http://dx.doi.org/10.3109/10915818909009122.
Texto completoDanilov-Danilyan, V. I. y O. M. Rozental. "Logistic Model of Population Toxicodynamics". Water Resources 49, n.º 2 (27 de marzo de 2022): 231–39. http://dx.doi.org/10.1134/s0097807822020038.
Texto completoTesis sobre el tema "Toxicodynamie"
Mit, Corentin. "Modélisation mécaniste de la dynamique de biomarqueurs chez les poissons téléostéens : lien entre exposition et effetsprécoces". Electronic Thesis or Diss., Paris, AgroParisTech, 2023. http://www.theses.fr/2023AGPT0001.
Texto completoBiomarkers are useful tools for the diagnosis of environmental risk in aquatic ecosystems. Nevertheless, the measurement of these sub-individual markers still presents some limitations for the assessment of ecosystem health, including the characterisation of the complex dynamics of responses of these non-lethal effects as a function of time or dose, or the extrapolation of responses from one scale of biological organisation to another. One of the solutions that seems promising for characterising the dynamics of these responses from a change of scale perspective would be to integrate the biomarkers into mechanistic models that make it possible to predict these dynamics and explain the mechanisms underlying the effects. This thesis proposes to build mechanistic models of physiologically based toxicokinetics and toxicodynamics (PBTK-TD) to better characterise and understand the response dynamics of biomarkers. In this context, the problem of biomarker dynamics was divided in two. First, the "toxico-kinetic" or TK makes it possible to link the external dose, present in the environment, to the internal dose, present in the organism. Second, the "toxico-dynamic" or TD, makes the link between the internal dose and the effect. Accordingly, the first step in this thesis was to collect a set of TK and TD data in our model species, the three-spined stickleback, on a family of compounds, the bisphenols, and more specifically, BPA, BPS and BPF. These data, collected from short-term exposures (seven days of contamination and seven days of depuration) and long-term exposure (21 days), were used to compare the modulating effects of bisphenols on biomarkers. In particular, markers of innate immunity were strongly impacted by these substances. Differences in kinetics between BPA and BPS were also highlighted. Subsequently, the data collected during the exposures were used to build a physiologically based TK model (PBTK) for BPA, then a PBTK model coupled with TD sub-models (PBTK-TD) describing the dynamics of certain immunomarkers in the stickleback. Finally, a last PBTK-TD model was built to demonstrate the feasibility of this modelling approach for integrating exposure conditions more representative of those in the natural environment, i.e. for a mixture of substances. Taken as a whole, this thesis demonstrates the attractiveness of coupling the experimental approach consisting in measuring biomarkers and modelling
Chaumet, Betty. "Transfert et distribution des pesticides dans les biofilms en lien avec les effets toxiques associés". Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0223/document.
Texto completoIn 2000, the Water Framework Directive required the return of rivers to good chemical and ecological status. In particular, it has classified 45 substances as priority for this assessment (Directive 2013/39/EU), including a large proportion of pesticides. Indeed, due to their massive use, these contaminants are now found in all compartments of the environment. In addition, given its ability to integrate contamination, biofilm is considered an excellent bioindicator for water quality assessment. It is at the base of the trophic chain in aquatic environments and is composed of microorganisms (microalgae, bacteria, fungi, etc...) embedded in a matrix of extracellular polymeric substances (EPS).This thesis focused on the analysis of mechanisms of pesticide transfer and distribution in biofilms related to toxic impacts. This work was carried out using a toxicokinetic approach whereby the bioaccumulation of diuron (a photosynthesis inhibitor herbicide) was monitored in the different compartments of the biofilm. This assessment was carried out under several abiotic conditions (flow velocity, temperatures and photoperiods) under varying exposure durations. In parallel, functional and structural descriptors were measured as photosynthetic (for autotrophic communities) and enzymatic (for heterotrophic communities) activities, as well as biofilm biomass and protein and polysaccharide production.All the experiments performed during this thesis made it possible to highlight the sorption mechanisms of diuron in biofilm, i.e. absorption processes by cells and adsorption phenomenon within the EPS matrix. Then the influence of the different environmental parameters studied was emphasized. This work demonstrates the relevance of the toxicokinetic-toxicodynamic approach to the study of the impact of pesticides on fluvial biofilms
Lewandowski, Thomas A. "Toxicokinetic and toxicodynamic modeling of the effects of methyl mercury on development of the embryonic rat midbrain /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8450.
Texto completoEverett, Scott D. "The Pharmacodynamics and Toxicodynamics of Inotropic Drugs in Calves With Natural and Artificial Hearts". DigitalCommons@USU, 1994. https://digitalcommons.usu.edu/etd/4103.
Texto completoBerggren, Kristina. "Toxicity of chlorantraniliprole to the Collembola Folsomia candida : toxicodynamics and effects of organic matter content". Thesis, Mittuniversitetet, Avdelningen för naturvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-24243.
Texto completoHeine, Simon [Verfasser]. "Development and specification of a toxicokinetic and toxicodynamic growth model of Myriophyllum spicatum for use in risk assessment / Simon Heine". Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065353502/34.
Texto completoDogruer, Gulsah. "Assessing the impact of chemical exposure on the health of endangered sea turtles through toxicokinetics and toxicodynamics". Thesis, Griffith University, 2022. http://hdl.handle.net/10072/420901.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environment and Sc
Science, Environment, Engineering and Technology
Full Text
Collet, Séverine. "Développement d’une approche toxicocinétique/toxicodynamique basée sur des mécanismes physiologiques pour évaluer les effets oestrogéniques du Bisphénol A". Thesis, Toulouse, INPT, 2012. http://www.theses.fr/2012INPT0001/document.
Texto completoThe goal of this thesis was to analyse through toxicokinetic (TK) and mechanistic approaches the estrogeno-mimetic effects of bisphenol A (BPA) on a precocious and sensitive biomarker: LH secretion in ovariectomized female lambs. The lowest plasma BPA concentrations associated to an inhibition of LH secretion appeared to be close to the highest one reported in human. LH suppression could be mediated by an inhibition of hypothalamic kisspeptin systems. The multispecies TK approach showed that BPA clearance is always high and equivalent to the liver blood flow. For an exposure scheme corresponding to the tolerable daily intake, this approach allows to predict human BPA concentration much lower than the one associated to LH inhibition in our highly sensitive lamb model
Black, Paleah. "Interactions of Dietary Antioxidants and Methylmercury on Health Outcomes and Toxicodynamics: Evidence from Developmental Rat Model Studies and Human Epidemiology". Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19874.
Texto completoGajewska, Monika Anna [Verfasser], Karl-Werner [Akademischer Betreuer] [Gutachter] Schramm y Heiko [Gutachter] Briesen. "Physiologically-based toxicokinetic and toxicodynamic modelling of single and repeated dose toxicity / Monika Anna Gajewska. Betreuer: Karl-Werner Schramm. Gutachter: Karl-Werner Schramm ; Heiko Briesen". München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1101695188/34.
Texto completoLibros sobre el tema "Toxicodynamie"
Tou, Grace. The pharmacokinetics of 2-acetamido-P-cresol and the effects of deacetylation on its toxicodynamics. Ottawa: National Library of Canada, 1991.
Buscar texto completoDrug Toxicodynamics (Drugs and the Pharmaceutical Sciences). Marcel Dekker Inc, 2006.
Buscar texto completoTekade, Rakesh Kumar. Essentials of Pharmatoxicology in Drug Research, Volume 1: Toxicity and Toxicodynamics. Elsevier Science & Technology Books, 2023.
Buscar texto completoEssentials of Pharmatoxicology in Drug Research, Volume 1: Toxicity and Toxicodynamics. Elsevier Science & Technology, 2023.
Buscar texto completoTekade, Rakesh Kumar. Public Health and Toxicology Issues in Drug Research, Volume 2: Toxicity and Toxicodynamics. Elsevier Science & Technology Books, 2023.
Buscar texto completoTou, Grace. The pharmacokinetics of 2-acetamido-P-cresol and the effects of deacetylation on its toxicodynamics. 1991.
Buscar texto completoCapítulos de libros sobre el tema "Toxicodynamie"
Cartus, Alexander y Dieter Schrenk. "Toxicodynamic Tests". En Regulatory Toxicology, 1–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-36206-4_39-2.
Texto completoEdler, Lutz. "Toxicodynamic Models". En Regulatory Toxicology, 1–9. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-36206-4_48-2.
Texto completoPhilip, Binu K., S. Satheesh Anand y Harihara M. Mehendale. "Toxicodynamic Interactions". En Principles and Practice of Mixtures Toxicology, 159–206. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527630196.ch6.
Texto completoSchrenk, Dieter. "Toxicodynamic Tests". En Regulatory Toxicology, 161–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35374-1_39.
Texto completoEdler, Lutz y Angelika Tritscher. "Toxicodynamic Models". En Regulatory Toxicology, 261–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35374-1_48.
Texto completoEdler, Lutz. "Toxicodynamic Models". En Regulatory Toxicology, 397–405. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57499-4_48.
Texto completoCartus, Alexander y Dieter Schrenk. "Toxicodynamic Tests". En Regulatory Toxicology, 215–29. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57499-4_39.
Texto completoHerber, Robert F. M. "Toxicokinetics and toxicodynamics - 1". En Fundamental Toxicology for Chemists, 17–25. Cambridge: Royal Society of Chemistry, 2007. http://dx.doi.org/10.1039/9781847550941-00017.
Texto completoRenwick, Andrew G. "Toxicokinetics and toxicodynamics - 2". En Fundamental Toxicology for Chemists, 26–42. Cambridge: Royal Society of Chemistry, 2007. http://dx.doi.org/10.1039/9781847550941-00026.
Texto completoBurcham, Philip C. "Toxicodynamics: How Chemicals Harm Cells". En An Introduction to Toxicology, 91–125. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-5553-9_4.
Texto completoActas de conferencias sobre el tema "Toxicodynamie"
Wittemer-Rump, Sabine, Anette Sommer, Charlotte Kopitz, Hung Huynh, Christoph Schatz, Ruprecht Zierz, Manuela Braun et al. "Abstract 1683: Pharmacokinetic/pharmacodynamic (PK/PD) and toxicokinetic/toxicodynamic (TK/TD) modeling of preclinical data of FGFR2-ADC (BAY 1187982) to guide dosing in phase 1". En Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1683.
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