Tesis sobre el tema "Thrombu"
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Mutch, Nicola J. "Thrombin activity in human thrombi and the vessel wall". Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340809.
Texto completoMoir, Elaine. "The pro- and anti-fibrinolytic properties of human leucocytes". Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340602.
Texto completoPetersen, Helen J. "Streptococcus-induced thrombus formation". Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541609.
Texto completoMachi, Paolo. "Evaluation expérimentale des propriétés mécaniques et de l'efficacité d'enlèvement des thrombus des stent retrievers". Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT263/document.
Texto completoA number of randomized controlled trials recently appeared in literature demonstrated that early mechanical thrombectomy offered to patients presenting with acute ischemic stroke is related to improved functional outcome in comparison to standard care intravenous fibrinolysis. Stent retrievers have been recognized in these trials as the most effective devices for intracranial thrombectomy. Currently, all industries producing neuro-interventional devices are launching into the market an increasing number of stent-based retriever tools. Each new device proposed for clinical use is supposed to have peculiar features allowing better performances in comparison to devices already available for clinical practice. Nevertheless, none clinical study has demonstrated so far the superiority, in terms of anatomical and clinical results, of a given stent retriever device. Furthermore, the mechanism of interaction between stent retrievers and thrombi has not exhaustively evaluated so far. In the present study we experimentally analyzed performances of all stent retrievers available into the French market up to Juin 2015. The aim of this study was to identify any device feature that was functional to the thrombus removal.Stent retrievers were evaluated by mechanical and functional test: mechanical tests were performed in order to investigate devices radial force, the aim was to evaluate the radial force exerted by the stent in two specific conditions: upon deployment and during the retrieval.Functional tests were aimed to visually evaluate the stent retriever’s ability in remaining in close apposition to the vessels wall and to maintain the thrombus engaged within its struts during the retrieval. We evaluated the interaction of the devices with thrombi of different features and sizes that we generated using human blood in order to obtain two types of clot: one softer “red type” that was composed by all elements of the whole blood and one stiffer “white type” that was mainly composed by platelet-rich plasma. Such tests were conducted using a rigid 3D printed vascular model reproducing the brain anterior circulation. Two neuro-interventionalists with experience in thrombectomy procedures performed functional tests, each experiment was filmed and two authors thereafter conducted visual analysis of the results.Mechanical tests showed different behavior in terms of radial pressure variation during retrieval for each stent. Constant radial pressure during retrieval was related to constant cohesion over the vessel wall during retrieval and higher rate of clot removal efficacy. All stent retrievers slide over the clot failing in clot removal when interact with white large thrombi (diameter>6 mm)
Ramaiola, Ilaria. "Thrombus composition in acute coronary syndrome". Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/456681.
Texto completoLa enfermedad aterotrombotica y concretamente la trombosis intracoronaria es la mayor causa de los síndromes coronarios agudos (SCA), y consecuentemente de morbilidad y mortalidad en el mundo. El manejo de los pacientes con infarto agudo de miocardio con elevación del segmento ST ha mejorado considerablemente en los últimos años, a pesar de esto sigue siendo necesario encontrar biomarcadores para la detección temprana de los procesos isquémicos y que permitan una estratificación más eficiente de los pacientes que han sufrido un evento isquémico agudo. De hecho, el tiempo de isquemia, definido como el tiempo entre el inicio del dolor y la revascularización, ha sido recientemente definido como el parámetro fundamental en el tratamiento de los pacientes con STEMI. Este trabajo de tesis está enfocado a elucidar la composición proteica de los trombos coronarios oclusivos que se forman tanto en las arterias coronarias nativas como en aquellas con stent. El estudio se basa en el análisis proteómico de trombos coronarios en relación al tiempo de isquemia, con la finalidad de encontrar nuevos biomarcadores para trasladar a la práctica clínica. Además, la comparación entre trombos nativos y trombos desarrollados sobre el stent permite la identificación de proteínas diferenciales que podrían ser futuras dianas terapéuticas para prevenir la formación del trombo en pacientes sometidos a angioplastia coronaria transluminal percutánea (ACTP) con implantación de un stent coronario.
Bowker, Timothy J. "A computational model for thrombus prediction". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558527.
Texto completoGlossop, Paul. "Thrombin inhibition". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244533.
Texto completoLevade, Marie. "Mécanismes moléculaires de la production et des fonctions plaquettaires : rôle de Vps34 et impact des inhibiteurs ciblés de kinases". Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30036.
Texto completoBlood platelets play an essential role in the maintenance of vascular integrity. They prevent excessive blood loss after vessel injury by orchestrating haemostatic clot formation through successive steps of adhesion, secretion and aggregation. Platelets are also major pharmacologic targets as they participate in thrombotic pathologies such as atherosclerosis. My thesis work was focused on two axis: (i) the role of class III PI3-kinase (Vps34) in platelet formation and activation and (ii) the impact of new anticancer drugs targeting kinases on platelet functions and haemostasis. First, I studied the role of Vps34 and its lipid product, phosphatidylinositol 3 monophosphate (PtdIns3P), in platelet physiology using a unique mouse model of Vps34 deletion specifically in megakaryocyte lineage (PF4-Cre/Vps34lox/lox). We observed a moderate microthrombocytopenia associated to a defect in megakaryocyte migration and morphologic abnormalities in secretion granules. This phenotype is linked to a decrease in PtdIns3P level associated with defective vesicular trafficking. Moreover, PF4-Cre/Vps34lox/lox mice exhibit altered prothrombotic functions, ex vivo in shear conditions and in vivo by conferring a protection against ferric chloride-induced carotid thrombosis. A role for Vps34 in platelet activation, independently from its role in megakaryocyte, was shown ex vivo using two specific Vps34 inhibitors (SAR405 and INH1) recently developed to reduce autophagy-mediated resistance to chemotherapy. Secondly, I assessed the impact of new targeted drugs used in cancer therapy on platelets in order to understand the increased bleeding risk associated to these molecules. We studied the effect of ibrutinib, a specific inhibitor of BTK family tyrosine kinases recently approved for the treatment of B malignancies (mantle cell lymphoma, chronic lymphocytic leukemia). By exploring platelet functions of ibrutinib-treated patients treated from Hematology department of Toulouse, we correlated bleeding symptoms to a defective platelet signaling downstream GPVI and GPIb receptors as shown by a strongly reduced platelet aggregation in response to collagen and CRP and by a defect in platelet adhesion on von Willebrand matrix under flow conditions. In conclusion, my thesis work (i) brings fundamental insights about Vps34 contribution in mechanisms of platelet production and functions and (ii) allows recommendations about clinical use of new targeted molecules in cancer therapy
Cardillo, Giulia. "Fluid Dynamic Modeling of Biological Fluids : From the Cerebrospinal Fluid to Blood Thrombosis". Thesis, Institut polytechnique de Paris, 2020. http://www.theses.fr/2020IPPAX110.
Texto completoIn the present thesis, three mathematical models are described. Three different biomedical issues, where fluid dynamical aspects are of paramount importance, are modeled: i) Fluid-structure interactions between cerebro-spinal fluid pulsatility and the spinal cord (analytical modeling); ii) Enhanced dispersion of a drug in the subarachnoid space (numerical modeling); and iii) Thrombus formation and evolution in the cardiovascular system (numerical modeling).The cerebrospinal fluid (CSF) is a liquid that surrounds and protects the brain and the spinal cord. Insights into the functioning of cerebrospinal fluid are expected to reveal the pathogenesis of severe neurological diseases, such as syringomyelia that involves the formation of fluid-filled cavities (syrinxes) in the spinal cord.Furthermore, in some cases, analgesic drugs -- as well drugs for treatments of serious diseases such as cancers and cerebrospinal fluid infections -- need to be delivered directly into the cerebrospinal fluid. This underscores the importance of knowing and describing cerebrospinal fluid flow, its interactions with the surrounding tissues and the transport phenomena related to it. In this framework, we have proposed: a model that describes the interactions of the cerebrospinal fluid with the spinal cord that is considered, for the first time, as a porous medium permeated by different fluids (capillary and venous blood and cerebrospinal fluid); and a model that evaluates drug transport within the cerebrospinal fluid-filled space around the spinal cord --namely the subarachnoid space--.The third model deals with the cardiovascular system. Cardiovascular diseases are the leading cause of death worldwide, among these diseases, thrombosis is a condition that involves the formation of a blood clot inside a blood vessel. A computational model that studies thrombus formation and evolution is developed, considering the chemical, bio-mechanical and fluid dynamical aspects of the problem in the same computational framework. In this model, the primary novelty is the introduction of the role of shear micro-gradients into the process of thrombogenesis.The developed models have provided several outcomes. First, the study of the fluid-structure interactions between cerebro-spinal fluid and the spinal cord has shed light on scenarios that may induce the occurrence of Syringomyelia. It was seen how the deviation from the physiological values of the Young modulus of the spinal cord, the capillary pressures at the SC-SAS interface and the permeability of blood networks can lead to syrinx formation.The computational model of the drug dispersion has allowed to quantitatively estimate the drug effective diffusivity, a feature that can aid the tuning of intrathecal delivery protocols.The comprehensive thrombus formation model has provided a quantification tool of the thrombotic deposition evolution in a blood vessel. In particular, the results have given insight into the importance of considering both mechanical and chemical activation and aggregation of platelets
Chalayer, Emilie. "Myélome multiple et maladie thrombo-embolique veineuse : aspects épidémiologiques, économiques, physiopathologiques et pharmacologiques". Thesis, Saint-Etienne, 2015. http://www.theses.fr/2015STET007T/document.
Texto completoThe association between multiple myeloma and venous thromboembolic disease is well established. This incidence in myeloma is on average from 10 to 20%. It appears to be higher in newly diagnosed myeloma and immunomodulatory drugs such as thalidomide might significantly increase the risk. However, the risk of thrombosis due to these treatments is not yet well defined. First, we performed a review of these diseases in order to delimit the field of this study through a literature review. Then, we evaluated the incidence of venous thromboembolic disease in patients with myeloma and treated with immunomodulatory, identified the thrombotic risk factors and evaluated the thrombotic risk assessment based on the physicians choice, through an observational, multicenter, prospective French study. Moreover, we performed the medico-economic analysis of the only randomized trial conducted to date on the thrombophylaxis in patients with multiple myeloma treated with thalidomide in the first line of chemotherapy. This analysis showed a gain in quality of life associated with significant cost savings in the prevention of thrombosis by aspirin rather than heparin. Finally we performed two medical studies using thrombin generation test, a global assay that measures the overall tendency of a plasma sample to form thrombin. The first study was conducted to predict patients who will have thrombosis. The second is performed to know if a heparin resistance with the usual doses in this pathology, exists
Koikkalainen, Janne Santeri. "Role of transglutaminases in model thrombus stability". Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424957.
Texto completoRouzet, François. "Développement de l'imagerie moléculaire du thrombus artériel". Thesis, Paris Est, 2011. http://www.theses.fr/2011PEST1116.
Texto completoArteriel or intra-luminal thrombus (ILT) is involved to various degrees in most of the degenerative cardiovascular diseases. Its detection and characterization is currently based on morphological imaging techniques that do not provide information about its possible evolution in relation to biological activities profile. In this context, molecular imaging of thrombus has three main objectives: (1) detection of the initial thrombus and of secondary locations, (2) evaluation of the thrombus evolutive potential and its impact on surrounding tissues in relationship with its biological activity, and (3) early assessment of therapeutic efficacy (before morphological changes). The aim of this work was to develop molecular imaging agents of biological activities of ILT. Regarding the proaggregant activity, we demonstrated a relationship between annexin A5 signal intensity and vegetation proaggregant activity in a model of infective endocarditis. We also developed a novel P-selectin imaging agent based on a natural high affinity ligand (fucoidan), and validated its ability to detect ILT in vivo. Regarding the plasminergic activity of ILT, we used radiolabelled aprotinin to detect plasmin in human aneurysmal thrombus ex vivo; we also initiated a collaboration to optimize its radiolabelling using a cystein-free tag peptide in N-terminal position. In parallel we developed a new approach based on a peptide inhibitor conjugated with a bifunctional chelating agent
Chinswangwatanakul, Vitoon. "The role of thrombin and thrombin receptor in pancreatic cancer". Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/7660.
Texto completoRichardson, John Lee. "Structural and kinetic characterization of the leech derived inhibitor haemadin in complex with human [alpha]-thrombin [alpha-thrombin] structural analysis of the tsetse thrombin inhibitor in complex with bovine [alpha]-thrombin [alpha-thrombin] /". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965976335.
Texto completoGiuliano, Simon 1975. "Calcium signalling regulating platelet adhesion and thrombus growth". Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7875.
Texto completoKuijpers, Marijke Johanna Elfrieda. "Platelet receptors and procoagulant activity in thrombus formation". [Maastricht] : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 2006. http://arno.unimaas.nl/show.cgi?fid=7651.
Texto completoWadoodi, Ashar. "The role of bone marrow in thrombus resolution". Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-bone-marrow-in-thrombus-resolution(2983faec-0618-4c4f-8897-7816419c55bd).html.
Texto completoGrover, Steven Philip. "Prolyl hydroxylase domain proteins in venous thrombus resolution". Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/prolyl-hydroxylase-domain-proteins-in-venous-thrombus-resolution(ff255bc6-858a-4155-88fc-963fe740f240).html.
Texto completoRouchaud, Aymeric. "Optimisation biologique du traitement endovasculaire des anévrysmes intracrâniens". Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCD046/document.
Texto completoThe genesis of an intracranial aneurysm is not only due to a mechanical effect but to a set of biological elements. Among them, intra-aneurysmal thrombus plays a major role, as it is the site of activation of many metalloproteinases and an important site of proteolysis. However, the thrombus of the aneurysmal sac is also crucial for the healing of the aneurysm after endovascular treatment, because it serves as a support for the recolonization of the aneurysm by mesenchymal cells. In the various works presented in this thesis, we analyzed some of the biological phenomena involved in the success or failure of endovascular treatments. The presented works are based on experiments in the elastase aneurysm model in the rabbit and treated with coils, flow-diverters or intra-saccular devices. This work enables to better understand the biological mechanisms involved in the various endovascular treatments. The analysis of these phenomena is essential to understand the causes of failure, but also to develop new biologically active devices for the treatment of intracranial aneurysms. We propose the development of biologically active flow-diverter stents. We also propose three different approaches of endovascular cell therapy, using autologous mesenchymal stem cells, allowing recolonization of the intra-aneurysmal thrombus and accelerated healing of the aneurysm. The treatment of intracranial aneurysms can no longer be based solely on mechanical considerations. The development of future endovascular devices should include a biological dimension to improve the complete healing of intracranial aneurysms
BRIOIS, JEAN-MICHEL. "Thrombus mobile de l'oreillette droite : a propos de 12 cas". Reims, 1991. http://www.theses.fr/1991REIMM021.
Texto completoSutherland, Michael R. "Thrombin production on herpesviruses". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq28465.pdf.
Texto completoMyles, Timothy. "Interactions of recombinant thrombin". Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627578.
Texto completoFlannery, Conor James. "Thrombus Formation under High Shear in Arterial Stenotic Flow". Thesis, Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6943.
Texto completoMooe, Thomas. "Left ventricular thrombus and stroke after acute myocardial infarction". Doctoral thesis, Umeå universitet, Medicin, 1997. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100547.
Texto completoS. 1-84: sammanfattning, s. 85-136: 5 uppsatser
digitalisering@umu
Humphries, Julia. "Monocyte recruitment and fibrinolytic activity in venous thrombus resolution". Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407326.
Texto completoCouturaud, Francis. "Risque de maladie thrombo-embolique veineuse chez les membres de familles au premier degré de patients ayant une maladie thrombo-embolique veineuse idiopathique". Lyon 1, 2006. http://www.theses.fr/2006LYO10184.
Texto completoRational : In patients with idiopathic venous thromboembolism (VTE), the risk of recurrent VTE is high and a large proportion of these patients carry inherited thrombophilia. Our hypothesis is that patients with idiopathic VTE without detectable inherited thrombophilia have a genetic prothrombotic state not yet discovered. Objective : To evaluate the risk of VTE in first degree relatives of patients with idiopathic VTE and with or without inherited thrombophilia. If our hypothesis is true, this risk should be similar, with or without thrombophilia. Methods : In this international multicentre study, 1778 first degree relatives of 348 propositus with objectively diagnosed idiopathic VTE were included. Relatives were classified as having “certain VTE”, “uncertain VTE” or “no VTE” according to a predefined and standardised questionnaire. All the propositus were tested for the Leiden mutation and the G20210A prothrombin gene mutation. Results : In multivariate analysis, when “uncertain VTE” were classified as “No VTE”, we observed a trend of an increased risk of VTE in first degree relatives of probants with an inherited thrombophilia (relative risk of 1,52 [0,98 – 2,37], p = 0,06); when “uncertain VTE” were classified as “certain VTE”, the relative risk of VTE was closed to 1. 0 (1,18 [0,87-1,60], p = 0,3). For each level of VTE diagnosis criteria precision, there was an increased risk of VTE in first degree relatives women and in relatives from younger probants. Conclusion : The presence of an inherited thrombophilia in patients with idiopathic VTE is weakly associated with an increased risk in their first degree relatives. This observation supports our scientific hypothesis. One the main implications of this study is that the prevention of VTE should not be proposed in only first degree relatives of patients with VTE and inherited thrombophilia
Day, Jonathan Robert Stewart. "Therapeutic inhibition of thrombin signalling". Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434321.
Texto completoSidhu, Preetpal. "Designing Allosteric Inhibitors of Thrombin". VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/295.
Texto completoDesai, Bijoy. "Novel Allosteric Inhibitors of Thrombin". VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1914.
Texto completoJones, Chris I. "Haematological and clinical factors influencing thrombus formation, structure and fibrinolysis". Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/29893.
Texto completoAcosta, Stefan. "On Acute Thrombo-Embolic Occlusion of the Superior Mesenteric Artery". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl.[distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4147.
Texto completoGARREAU, OLIVIER. "Thrombus recidivant de l'aorte ascendante diagnostique par echocardiographie trans-oesophagienne". Reims, 1994. http://www.theses.fr/1994REIMM072.
Texto completoAndré, Jean-Claude. "Le thrombus neoplasique cave superieur : a propos de deux observations". Lyon 1, 1993. http://www.theses.fr/1993LYO1M096.
Texto completoKobold, Jonathan. "Deep Learning for lesion and thrombus segmentation from cerebral MRI". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLE044.
Texto completoDeep learning, the world's best set of methods for identifying ob-jects on images. Stroke, a deadly disease whose treatment requiresidentifying objects on medical imaging. Sounds like an obvious com-bination yet it is not trivial to marry the two. Segmenting the lesionfrom stroke MRI has had some attention in literature but thrombussegmentation is still uncharted area. This work shows that contem-porary convolutional neural network architectures cannot reliablyidentify the thrombus on stroke MRI. Also it is demonstrated whythese models don't work on this problem. With this knowledge arecurrent neural network architecture, the logic LSTM, is developedthat takes into account the way medical doctors identify the throm-bus. Not only this architecture provides the first reliable thrombusidentification, it also provides new insights to neural network design.Especially the methods for increasing the receptive field are enrichedwith a new parameter free option. And last but not least the logicLSTM also improves the results of lesion segmentation by providinga lesion segmentation with human level performance
CARISSIMI, GUY. "Thrombus graisseux de la veine cave inferieure : apports de l'imagerie". Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20066.
Texto completoAndersen, Henrik. "Human protease activated receptor 4 and its role in platelet activation /". Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/9235.
Texto completoLaurent, Pierre-Alexandre. "Rôles des phosphoinositides 3-kinases (PI3Ks) α et β de classe IA dans les processus de l'activation plaquettaire et de la thrombose". Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30296.
Texto completoPlatelets play a major role in cardiovascular diseases which is one principal cause of worldwide death. Class I phosphoinositide 3-kinases (PI3Ks) are important signaling enzymes in the process of blood platelet activation, producing lipid second messengers (D3-phosphoinositides) that are actively involved downstream of major platelet receptors. PI3Kbeta has been proposed as a potential drug target to treat arterial thrombosis. Indeed, inhibition of this lipid kinase leads to protection against occlusive thrombosis without bleeding risk. Nevertheless, nothing is known regarding the role of this kinase in vivo and ex vivo during growth, stabilization, and resistance upon elevation of shear rate. One study, using pharmacological inhibitors, has suggested that both PI3Kalpha and beta are required, in a non redundant way, for full platelet activation through collagen receptor GPVI, but the role of PI3Kalpha still remains elusive in platelets. The aim of my thesis was to study the role of PI3Kbeta during thrombus formation in vivo and ex vivo, and to characterize the role of PI3Kalpha in platelets. For that, I used pharmacological approach and mice with selective deletion of PI3Kbeta?or?PI3Kalpha in the megakaryocyte lineage (PF4-Cre/p110betaflox/flox and PF4-Cre/p110alphaflox/flox). I showed that PI3Kbeta is essential for thrombus growth and stability at high shear rates. Within the growing platelet thrombus, PI3Kbeta inactivation impairs the activating phosphorylations of Akt and the inhibitory phosphorylation of GSK3. In line with these data, pharmacological inhibition of GSK3 restores thrombus stability. Thus, platelet PI3Kbeta has a critical role in maintaining the integrity of the formed thrombus upon elevation of shear rate. In this condition, I showed that PI3Kbeta absence cannot be compensated by PI3Kalpha. In vitro, PI3Kalpha depletion in platelets leads to a light defect of aggregation and Akt activation in response to CRP showing implication of PI3Kalpha downstream GPVI. I observed that, in vivo, thrombi formed by PI3Kalpha depleted platelets after superficial lesion of mesenteric arterial are smaller, and ex vivo, thrombus formation under flow conditions on collagen matrix is delayed. Furthermore, perfusion of these platelets on von Willebrand factor matrix (vWF) shows that PI3Kalpha is required for stable adhesion of platelets through "outside in" signaling. Altogether, these results show an involvement of PI3Kalpha in the course of early step of platelet adhesion. In conclusion, my thesis work highlights an isoform specific role of PI3Ks in platelets. PI3Kbeta is crucial in the regulation of thrombus growth and stability at a high shear rate and PI3Kalpha is required in initial stages of platelet adhesion. Since class I PI3Ks selective inhibitors are under development as cancer treatment, these results may help to anticipate the potential side effects of such treatment on haemostasis
Rowand, Judith K. "Comparative structural studies of proteolyzed human thrombin forms and bovine thrombin through use of hirudin analogs /". The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487688973685458.
Texto completoPianfetti, Christophe. "Thrombus intracardiaque simulant un myxome dans le cadre du syndrome des antiphospholides". Montpellier 1, 1998. http://www.theses.fr/1998MON11135.
Texto completoMehrabadi, Marmar. "Effects of red blood cells and shear rate on thrombus growth". Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53082.
Texto completoAuger, Jocelyn M. "Investigation of the signalling events that underline thrombus formation under flow". Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433505.
Texto completoShand, Ray Ann. "Investigations of thrombus formation in an animal model of arterial thrombosis". Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236715.
Texto completoCHRETIEN, CLAUDINE. "Maladies thrombo-emboliques et affections malignes : a propos de 11 observations". Reims, 1989. http://www.theses.fr/1989REIMM086.
Texto completoBONNAUD, MARC. "Anomalies du plasminogene et phenomenes thrombo-emboliques : a propos d'un cas". Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20185.
Texto completoYvorra, Serge. "La maladie veineuse thrombo-embolique ambulatoire : donnees epidemiologiques, etiologiques, et suivi". Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20856.
Texto completoBobbert, Thomas. "Thrombin-induzierte Differenzierung neonataler glatter Gefämuskelzellen". [S.l.] : [s.n.], 2003. http://www.diss.fu-berlin.de/2003/58/index.html.
Texto completoGiesen, Peter Leonardus Arnoldus. "Production of thrombin at macroscopic surfaces". Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=5672.
Texto completoKakkar, Ajay Kumar. "Tissue factor, thrombin generation and cancer". Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286352.
Texto completoBevan, Shaun Patrick. "The clinical utility of thrombin generation". Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1398.
Texto completoLisiak, Karolina. "The role of platelets in the activation of TAFI in model thrombi". Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24805.
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