Índice
Literatura académica sobre el tema "Thérapie par remplacement des mitochondries"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Consulte las listas temáticas de artículos, libros, tesis, actas de conferencias y otras fuentes académicas sobre el tema "Thérapie par remplacement des mitochondries".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Artículos de revistas sobre el tema "Thérapie par remplacement des mitochondries"
O’Connor, Kieron P. y Marie-Claude Pélissier. "Le rôle du raisonnement inductif dans le trouble délirant". Santé mentale au Québec 32, n.º 2 (25 de marzo de 2008): 129–49. http://dx.doi.org/10.7202/017801ar.
Texto completoFarrell, Catherine A. "Le diagnostic et la prise en charge du sepsis grave chez le patient pédiatrique". Paediatrics & Child Health 25, n.º 7 (noviembre de 2020): 476. http://dx.doi.org/10.1093/pch/pxz180.
Texto completoSchultz, Meredith, Kathryn Swoboda, Kamal Benguerba, Elaine Kernbauer, Francis Ogrinc, Douglas E. Feltner, Bryan E. Mcgill, Douglas M. Sproule y Kevin A. Strauss. "Essai clinique portant sur la thérapie de remplacement d’un gène par AVXS-101 dans le traitement de l’amyotrophie spinale (ASI) pré-symptomatique : conception de l’étude de phase 3 et données démographiques lors de la visite de référence initiale". Revue Neurologique 175 (abril de 2019): S150—S151. http://dx.doi.org/10.1016/j.neurol.2019.01.335.
Texto completoJoy, Melanie S., Gary R. Matzke, Deborah K. Armstrong, Michael A. Marx y Barbara J. Zarowitz. "A Primer on Continuous Renal Replacement Therapy for Critically Ill Patients". Annals of Pharmacotherapy 32, n.º 3 (marzo de 1998): 362–75. http://dx.doi.org/10.1345/aph.17105.
Texto completoGage, Brittany, Julia Lamb y Karen Dahri. "Evaluation of In-Hospital Management of Inhaler Therapy for Chronic Obstructive Pulmonary Disease". Canadian Journal of Hospital Pharmacy 74, n.º 2 (19 de abril de 2021). http://dx.doi.org/10.4212/cjhp.v74i2.3097.
Texto completoMcKenna, Sarah, Alexandra Cheung, Amanda Wolfe, Brenda L. Coleman, Michael E. Detsky, Laveena Munshi, Dawn Maze y Lisa Burry. "Clinical Interventions to Prevent Tumour Lysis Syndrome in Hematologic Malignancy: A Multisite Retrospective Chart Review". Canadian Journal of Hospital Pharmacy 72, n.º 6 (16 de diciembre de 2019). http://dx.doi.org/10.4212/cjhp.v72i6.2943.
Texto completoTesis sobre el tema "Thérapie par remplacement des mitochondries"
Mayeur, Anne. "La prévention des maladies mitochondriales par mutation de l'ADNmt : de la clinique au transfert de pronoyaux". Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL084.
Texto completoMitochondria have the unique characteristic of possessing their own genome, mitochondrial DNA (mtDNA), which is exclusively transmitted by the mother through the cytoplasm of the oocyte. Pathogenic mutations in mtDNA are responsible for mitochondrial diseases. Pronuclear transfer (PNT), not authorized in France, is a technique proposed by the United Kingdom since 2016 to replace the mutated mitochondrial genome of a zygote with a non-mutated one. This method remains widely debated internationally regarding its efficacy and safety. The aim of our work was to evaluate the clinical and and technical feasibility of PNT. Our research confirmed that women carrying a pathogenic variant of mtDNA exhibited ovarian response criteria to stimulation comparable to a control group. Through a sociological study, we also showed that this technique received support from the majority of women surveyed, primarily because it maintains a genetic link between a woman and her child. Subsequently, we developed the PNT technique using triploid zygotes (3PN) donated for research, following authorization from the Biomedicine Agency. Finally, we assessed the relevance of using 3PN and demonstrated their limitations in terms of development and chromosomal status, even when diploidy was restored. This work opens up perspectives on the feasibility and acceptance of PNT. Future research is necessary to explore the safety of this technique
Sourdeval, Matthieu. "Etude des mécanismes de l'apoptose (anoikis) induite par les moutardes sur les cellules respiratoires humaines en culture et recherche d'agents protecteurs". Paris 7, 2006. http://www.theses.fr/2006PA077165.
Texto completoYperite and mechlorethamine induce cell death in airway cells by apoptosis related to cell detachment, or anoikis. Preliminary processes generating detachment included mitochondria alteration, activation of caspase-2, disruption of microfilaments network and reorganization of adhesion membrane proteins. After detachment, the apoptotic process involved the implication of caspases, mitochondria and p53. According to these signaling pathways, we identified protectors, inhibitors of mitochondrial alteration: ebselen, melatonin and cyclosporin A. They exerted a protective effect in decreasing both cell detachment and cell death and provided maintain of microfilaments and adhesion proteins, thus contributing to the cell survey. A protective effect of doxycyclin, an anti-protease, was also revealed, but limited since it interfered with its own toxicity. However, doxycyclin induces cell proliferation inhibition and mitochondrial-dependent apoptosis, representing new insight in cancer therapy
Pichette, Maxime. "Fonction auriculaire gauche dans la maladie de Fabry par analyse échocardiographique de la déformation myocardique". Thèse, 2017. http://hdl.handle.net/1866/19440.
Texto completoBackground: Fabry disease (FD) is characterized by the accumulation of sphingolipids in multiple organs including the left atrium (LA). It is uncertain if the LA reservoir, conduit and contractile functions evaluated by speckle-tracking echocardiography are affected in Fabry cardiomyopathy and whether enzyme replacement therapy can improve LA function. Methods: In this retrospective cohort study, LA strain, strain rates and phasic LA volumes were studied in 50 FD patients and compared to 50 healthy controls. Results: All three LA phasic functions were altered. The peak positive strain (reservoir function) was 38.9 ± 14.9 % vs. 46.5 ± 10.9 % (p=0.004) and the late diastolic strain (contractile function) was 12.6 ± 5.9 % vs. 15.6 ± 5.3 % (p=0.010). In 15 patients who started enzyme replacement therapy during the study, most of the LA parameters improved at one-year follow-up (peak positive strain from 32.0 ± 13.5 % to 38.0 ± 13.5 %; p=0.006) whereas there was a trend towards deterioration in 15 patients who never received treatment (peak positive strain from 47.3 ± 10.8 % to 41.3 ± 9.3 %; p=0.058). Nine FD patients (21%) experienced new-onset atrial fibrillation or stroke during four-year follow-up. By univariate analysis, peak positive strain and early diastolic strain demonstrated significant associations with clinical events, surpassing conventional echocardiographic parameters and clinical characteristics. Conclusions: Left atrial reservoir, conduit and contractile functions by speckle-tracking echocardiography were all affected in FD. Enzyme replacement therapy improved LA function. Left atrial strain parameters were associated with atrial fibrillation and stroke.