Artículos de revistas: "Technique de neuromodulation"

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Yamamoto, Takamitsu. "Functional Neurosurgery with Neuromodulation Technique". Journal of Nihon University Medical Association 76, n.º 1 (2017): 40–44. http://dx.doi.org/10.4264/numa.76.1_40.

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Abejón, David y Enrique Reig. "Is Pulsed Radiofrequency a Neuromodulation Technique?" Neuromodulation: Technology at the Neural Interface 6, n.º 1 (enero de 2003): 1–3. http://dx.doi.org/10.1046/j.1525-1403.2003.03009.x.

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Matzel, Klaus E., Emmanuel Chartier-Kastler, Charles H. Knowles, Paul A. Lehur, Arantxa Muñoz-Duyos, Carlo Ratto, Mona B. Rydningen, Michael Sørensen, Philip van Kerrebroeck y Stefan de Wachter. "Sacral Neuromodulation: Standardized Electrode Placement Technique". Neuromodulation: Technology at the Neural Interface 20, n.º 8 (4 de octubre de 2017): 816–24. http://dx.doi.org/10.1111/ner.12695.

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Ratto, Carlo, Umberto Morelli, Stefania Paparo, Angelo Parello y Giovanni Battista Doglietto. "Minimally Invasive Sacral Neuromodulation Implant Technique". Diseases of the Colon & Rectum 46, n.º 3 (marzo de 2003): 414–17. http://dx.doi.org/10.1007/s10350-004-6565-6.

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Reffat, Noora, Carolina Pusec, Scott Price, Mayank Gupta, Philippe Mavrocordatos y Alaa Abd Elsayed. "Neuromodulation Techniques for Headache Management". Life 14, n.º 2 (24 de enero de 2024): 173. http://dx.doi.org/10.3390/life14020173.

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This narrative review aims to summarize evidence regarding the current utilization and future applications of neuromodulation in patients with headaches, with special attention paid to migraine and chronic cluster headache. A search was conducted in PubMed in August of 2023 to survey the current literature on neuromodulation for the treatment of headache. In total, the search yielded 1989 results, which were further filtered to include only systematic reviews published between 2022 to 2023 to capture the most up-to-date and comprehensive research on this topic. The citation lists of these articles were reviewed to find additional research on neuromodulation and supplement the results presented in this paper with primary literature. Research on the use of neuromodulation for the treatment of headache has predominantly focused on four neuromodulation techniques: peripheral nerve stimulation (PNS), transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and spinal cord stimulation (SCS). Outcome measures reported in this article include impact on migraine and headache frequency and/or pain intensity, adverse effects of the neuromodulation technique, and associated costs, when available. We found that neuromodulation has developed utility as an alternative treatment for both chronic cluster headaches and migraines, with a reduction in frequency and intensity of headache most elucidated from the articles mentioned in this review.

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Shirane, Risako, Eonjung Kim, Daniela Riveros y Huma Sheikh. "Neuromodulation for Prevention and Treatment of Headache Disorders". US Neurology 18, n.º 2 (2022): 103. http://dx.doi.org/10.17925/usn.2022.18.2.103.

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Neuromodulation is a treatment modality that can be used in the abortive and preventive treatment of migraine and other primary headache disorders. The basic concept of neurostimulation is to manipulate peripheral or central pain pathways with either magnetic or electrical impulses. Common neuromodulation techniques include occipital nerve stimulation, which is the oldest technique, and trigeminal nerve stimulation, combined occipital and trigeminal nerve stimulation, sphenopalatine ganglion stimulation, vagus nerve stimulation and transcranial magnetic stimulation, which were introduced soon after. The two newest modalities are remote electrical neuromodulation and caloric vestibular stimulation, the last of which is still in the experimental phases.

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Ammirati, Enrico, Alessandro Giammò, Alberto Manassero y Roberto Carone. "Neuromodulation in urology, state of the art". Urologia Journal 86, n.º 4 (1 de agosto de 2019): 177–82. http://dx.doi.org/10.1177/0391560319866075.

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Sacral neuromodulation is an approved and validated treatment for overactive bladder syndrome, chronic non-obstructive retention, and chronic pelvic pain. Percutaneous tibial nerve stimulation is a less invasive approach of neuromodulation. We performed a literature research to assess the current evidence available about neuromodulation. Both techniques appear to be effective and safe third-line treatments. The overall success rate ranges from 43% to 85% for sacral neuromodulation and from 40% to 79.5% for percutaneous tibial nerve stimulation. Sacral neuromodulation has a higher incidence of complications in comparison to percutaneous tibial nerve stimulation, due to the more invasive surgical technique and the presence of a permanent implant. The incidence of surgical revision ranges between 9% and 33%. The most frequent complication with sacral neuromodulation is pain at implant site (15%–42%), followed by lead migration (4%–21%), pain at lead site (5.4%–19.1%), leg pain (18%), and infection (5.7%–6.1%). The quality of the studies on sacral neuromodulation and percutaneous tibial nerve stimulation in literature is quite modest, because of the shortage of good randomized clinical trial; most of the studies are prospective observational studies with mid-term follow-up.

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Hoang Roberts, L., C. Shenhar, J. Booher, L. Gleich, K. Peters y M. Tracy Bee. "NOVEL PUDENDAL NEUROMODULATION TECHNIQUE USING ANATOMICAL LANDMARKS". Continence 7 (septiembre de 2023): 100763. http://dx.doi.org/10.1016/j.cont.2023.100763.

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Tuccitto, G., L. Maccatrozzo, M. Mangano, P. Checchin y G. Anselmo. "Neuromodulation: A new frontier?" Urologia Journal 64, n.º 1 (febrero de 1997): 119–22. http://dx.doi.org/10.1177/039156039706400129.

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It is often impossible to identify the precise cause of urethrocystalgia at radiological and functional confirmation of diagnosis and therapy is therefore frequently symptomatic without resolving the underlying cause. Neuromodulation by stimulating the sacral nerves of the vertebral foramina has recently been introduced into clinical practice. At present only a few specialised centres have implemented this therapy as second choice in treating lower urinary tract dysfunction secondary to detrusorial hyper- or hypoactivity and pelvic pain. The authors review literature on the subject and report on the multi-centre experience of Brescia, Padua and Treviso in treating urethrocystalgias. A method has been used that is by now standardised with regard to temporary percutaneous stimulation techniques and final implant. Ways of correctly identifying predictive factors which would indicate suitability for application of the method are, however, still unclear. It is to be hoped that studies involving larger numbers of cases may provide the answers, so that specialists can apply the technique more correctly.

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Moscovich, Mariana, Camila Henriques de Aquino, Murilo Martinez Marinho, Lorena Broseghini Barcelos, André C. Felício, Matthew Halverson, Clement Hamani, Henrique Ballalai Ferraz y Renato Puppi Munhoz. "Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 2". Arquivos de Neuro-Psiquiatria 82, n.º 04 (abril de 2024): 001–9. http://dx.doi.org/10.1055/s-0044-1786037.

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AbstractThe field of neuromodulation has evolved significantly over the past decade. Developments include novel indications and innovations of hardware, software, and stimulation techniques leading to an expansion in scope and role of these techniques as powerful therapeutic interventions. In this review, which is the second part of an effort to document and integrate the basic fundamentals and recent successful developments in the field, we will focus on classic paradigms for electrode placement as well as new exploratory targets, mechanisms of neuromodulation using this technique and new developments, including focused ultrasound driven ablative procedures.

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Kong, Lanhe y Ruqi Wang. "Modalities of Neuromodulation for Neurological Diseases". Highlights in Science, Engineering and Technology 36 (21 de marzo de 2023): 166–75. http://dx.doi.org/10.54097/hset.v36i.5657.

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Neurological diseases have attracted much attention as they have become the second leading cause of death worldwide. Several works on neuromodulation were reported to improve patients' quality of life or the body's functionality. After the early discovery of the gating theory, electrical stimulation was used to relieve chronic pain. In recent years, several other neuromodulation techniques, including thermal, and pharmacological stimulation, were proposed to improve the effectiveness. In this paper, some of the related researches on electrical, thermal, and pharmacological stimulation are summarized. Scientists are searching for more suitable therapies for neuromodulation now, including improving probe and electrode materials based on existing protocols. In terms of thermal stimulation, light-induced heating of heat conversion materials are introduced. The three administration routes of oral, intravenous and micropump in pharmacological are also mentioned. It also highlight the researches that combine some new cutting-edge technologies (e.g. nanotechnology) with the neuromodulation technique. In the end, the advantages and disadvantages are discussed, and the prospects are forecasted.

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Pagani-Estévez, Gabriel L. "Occipital Neuromodulation: A Surgical Technique with Reduced Complications". Pain Physician 7;19, n.º 7;9 (14 de septiembre de 2016): E1005—E1012. http://dx.doi.org/10.36076/ppj/2016.19.e1005.

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Background: Occipital neuromodulation is a promising treatment modality for refractory headache, but lead migration remains a frequent surgical complication. Objectives: The primary objective was to identify surgical techniques that may minimize adverse events, particularly lead migration. We hypothesized that a surgical technique employing 2-point anchoring of stimulator leads designed to provide a tension-relief loop and the use of ultrasound for lead placement would decrease the complication rate. Study Design and Setting: A retrospective analysis was performed through electronic medical record chart review in a tertiary referral center. Methods: Institutional Review Board (IRB) approval was obtained. Eighteen patients had a trial and subsequent permanent occipital nerve stimulator (ONS) implantation between 2004 and 2011 and were included. Adverse events were recorded and efficacy outcome variables analyzed for significance. Results: The cohort was a median (IQR) 45 (37 – 58) in age and 9 (50%) were women. Tension-relief loops placed via a 2-point anchoring technique and ultrasound use for occipital lead placement were evident in 16 (89%) and 13 (72%), respectively. There was one (6%) clinically insignificant lead position change, not definitively a lead migration, which could have been an artifact of fluoroscope positioning. Adverse events included one (6%) battery malfunction, one (6%) lead malfunction, and 2 (12%) post-implantation infections. Following ONS, there were significant reductions in numeric rating scale (NRS) pain scores from a median (IQR) of 9.5 (8.25 – 10) to 2.5 (1 – 4.75) (P < 0.0001), headache days per week from 7 (7 – 7) to 1.5 (0.375 – 1.75) (P = 0.0005), and the number of daily headache medication from 3 (2.25 – 4) to 2.5 (2 – 3.75) (P = 0.0112). Limitations: Limitations include retrospective study design, investigator bias, and nonstandardized intervals of headache burden assessment. Conclusions: In ONS, utilization of a 2-point anchoring technique with a tension-relief loop may significantly minimize the risk of lead migration, based on the absence of definitive lead migration in our series. Ultrasound use may improve the anatomic accuracy of lead placement with the possibility of improved efficacy. ONS was associated with significantly decreased headache pain, frequency, and medication use. Key words: Occipital neuromodulation, occipital nerve stimulation, surgical technique, lead migration, tension-relief loop

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Zhao, Kevin, Christopher E. Talbot, Antonios Mammis y Boris Paskhover. "Neuromodulation of the lingual nerve: a novel technique". Neurosurgical Focus: Video 3, n.º 2 (octubre de 2020): V6. http://dx.doi.org/10.3171/2020.7.focvid2018.

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The lingual nerve is a branch of the posterior trunk of the mandibular nerve. It provides sensation and taste to the ipsilateral anterior two-thirds of the tongue. Posttraumatic neuropathy of the lingual nerve can be chronic and debilitating long after the inciting trauma. In this operative video, the authors describe a novel technique for the treatment of lingual nerve neuropathy with neuromodulation. They present a case of a 69-year-old female with posttraumatic lingual nerve neuropathy after left molar extraction. The patient reported 95% symptom improvement after the procedure. This video demonstrates the feasibility of lingual nerve neuromodulation.The video can be found here: https://youtu.be/l-CKP8-8eqk

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Spivak, Norman M., Joseph L. Sanguinetti y Martin M. Monti. "Focusing in on the Future of Focused Ultrasound as a Translational Tool". Brain Sciences 12, n.º 2 (25 de enero de 2022): 158. http://dx.doi.org/10.3390/brainsci12020158.

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This article summarizes the field of focused ultrasound for use in neuromodulation and discusses different ways of targeting, delivering, and validating focused ultrasound. A discussion is focused on parameter space and different ongoing theories of ultrasonic neuromodulation. Current and future applications of the technique are discussed.

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Medina-Ramírez, Raquel, Milos Mallol Soler, Franc García, Francesc Pla, Aníbal Báez-Suárez, Esther Teruel Hernández, D. David Álamo-Arce y María del Pino Quintana-Montesdeoca. "Effects in Sleep and Recovery Processes of NESA Neuromodulation Technique Application in Young Professional Basketball Players: A Preliminary Study". Stresses 4, n.º 2 (2 de abril de 2024): 238–50. http://dx.doi.org/10.3390/stresses4020014.

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The competitive calendars in sports often lead to fluctuations in the effort-recovery cycle and sleep quality. NESA noninvasive neuromodulation, achieved through microcurrent modulation of the autonomic nervous system, holds promise for enhancing sleep quality and autonomic activation during stressful situations. The objective of this study was to analyze the sleep and recovery responses of basketball players over six weeks of training and competition, with the integration of NESA noninvasive neuromodulation. A preliminary experimental study involving 12 participants was conducted, with a placebo group (n = 6) and an intervention group (n = 6) treated with NESA noninvasive neuromodulation. Sleep variables and biomarkers such as testosterone, cortisol, and the cortisol:testosterone ratio were analyzed to assess player recovery and adaptations. Significant differences were observed in total, duration, and REM sleep variables (p-value= < 0.001; 0.007; <0.001, respectively) between the intervention and placebo groups. The intervention group demonstrated increased duration of sleep variables. Cortisol levels showed normalization in the experimental group, particularly in the last two weeks coinciding with the start of playoffs. This study highlights the potential of NESA noninvasive neuromodulation to enhance sleep quality despite challenging circumstances, providing valuable insights into the management of athlete recovery in competitive sports settings.

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Iacona, Roberta, Lisa Ramage y Georgina Malakounides. "Current State of Neuromodulation for Constipation and Fecal Incontinence in Children: A Systematic Review". European Journal of Pediatric Surgery 29, n.º 06 (16 de enero de 2019): 495–503. http://dx.doi.org/10.1055/s-0038-1677485.

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Background Neuromodulation is the application of electrical stimulation on nerve fibers to modulate the neuronal activity. Its use for chronic constipation and fecal incontinence has increased in popularity over the past few years. Invasive and noninvasive techniques are currently available. We reviewed the current literature on the application of the neuromodulation techniques in the management of chronic constipation and fecal incontinence in children. Materials and Methods A search of Healthcare Database Advanced Search, Embase, Medline, and Cochrane database was performed in accordance with PRISMA guideline. Terms used in the search included neuromodulation, nerve stimulation, fecal/fecal incontinence, incontinence, constipation, children, and pediatric/pediatric. Results Two-hundred forty-one papers were screened. Fourteen papers were included for the systematic review: seven were selected for the ISNM (implantable sacral nerve modulation) technique, one for the transcutaneous tibial nerve stimulation), one for the transcutaneous sacral nerve modulation), and five for the transcutaneous interferential sacral nerve stimulation. Results showed an overall improvement in constipation symptoms in 79 to 85.7% of patients, resolution of symptoms in 40%, reduced use of ACE stoma/transanal irrigation system in 12.5 to 38.4%, and improvement in incontinence symptoms in 75%. High complication rate was reported (17–50%) in the ISNM group. No complications were reported in the non-invasive group. Conclusion Neuromodulation is a promising tool in the management of constipation refractory to medical treatment and fecal incontinence in children. Noninvasive techniques provide good results with no complications. A longer term follow-up will provide more information regarding patient compliance and sustainability of benefits of these new techniques.

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Ahmad, Shahjehan, Ryan Khanna y Sepehr Sani. "Surgical Treatments of Epilepsy". Seminars in Neurology 40, n.º 06 (11 de noviembre de 2020): 696–707. http://dx.doi.org/10.1055/s-0040-1719072.

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AbstractNearly 30% of epilepsy patients are refractory to medical therapy. Surgical management of epilepsy is an increasingly viable option for these patients. Although surgery has historically been used as a palliative option, improvements in technology and outcomes show its potential in certain subsets of patients. This article reviews the two main categories of surgical epilepsy treatment—resective surgery and neuromodulation. Resective surgery includes temporal lobe resections, extratemporal resections, laser interstitial thermal therapy, and disconnection procedures. We discuss the three main types of neuromodulation—vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation for epilepsy. The history and indications are explored for each type of treatment. Given the myriad types of resection and neuromodulation techniques, patient selection is reviewed in detail, with a discussion on which patients are most likely to benefit from different treatment strategies. We also discuss outcomes with examples of the pertinent landmark trials and their results. Finally, complications and surgical technique are reviewed. As new indications emerge and patient selection is refined, surgical management will continue to evolve as an adjuvant therapy for epileptic patients.

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Kurt, Erkan. "Neuromodulation of the Suprascapular Nerve". Pain Physician 1;19, n.º 1;1 (14 de enero de 2016): E235—E239. http://dx.doi.org/10.36076/ppj/2016.19.e235.

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Chronic intractable shoulder pain (CISP) is defined as shoulder pain which is present for longer than 6 months and does not respond to standard treatments like medication, physical therapy, rehabilitation, selective nerve blocks and local infiltrations, or orthopedic procedures. The etiology of CISP may be very diverse, varying from many orthopedic conditions to non-orthopedic conditions. The fact that the suprascapular nerve is one of the most important nerves supplying the shoulder region makes this nerve an interesting target in treating patients suffering shoulder pain. Invasive treatment options are peripheral nerve blocks, temporary electrical stimulation, and neurostimulation. To our best knowledge, thus far there are only a few reports describing the technique of permanent neurostimulation of the suprascapular nerve. In this article we present a patient suffering shoulder pain after she underwent surgery for cervical stenosis. After a step by step treatment protocol was done, we finally offered her trial stimulation of the suprascapular nerve. A single quad lead was implanted via a posterior approach under fluoroscopic and ultrasound guidance. Two weeks after successful stimulation, we implanted a permanent neuromodulation system. Permanent neurostimulation of the suprascapular nerve and its end branches may be a new interesting target in treating patients suffering shoulder pain due to various etiologies. In our patient the followup period is 9 months with an excellent result in pain relief, we observed no complications thus far, especially no dislocation or breakage of the lead. In this report, literature on this subject is reviewed, and our technique is well documented with additional anatomical illustrations. Key words: Suprascapular nerve, shoulder pain, peripheral nerve stimulation, neuromodulation, neurostimulation, chronic pain

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Shipton, Edward A. "Movement Disorders and Neuromodulation". Neurology Research International 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/309431.

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Movement disorders are neurological conditions affecting speed, fluency, quality, and ease of movement. Deep brain stimulation (DBS) is used to treat advanced Parkinson’s disease, essential tremor, and dystonia. Possible target sites for DBS include the ventral intermediate nucleus of the thalamus, the globus pallidus internus, and the subthalamic nucleus. High-frequency DBS leads to a kind of functional deafferentation of the stimulated structure and to the modulation of cortical activity. This has a profound effect on the efficiency of movement. Indications for the use of DBS include the need to improve function, reduce medication dependency, and avoid ablative neurosurgery. Appropriate patient selection is critical for success. The implantation technique is briefly described. Programming stimulation parameters are performed via telemetry. The adverse effects of DBS are discussed. The future should see the development of “closed-loop” systems. Its use has promoted interdisciplinary team work and provided an improved understanding of the complex neurocircuitry associated with these disorders. DBS is a highly effective, safe, and reversible surgical treatment for advanced Parkinson’s disease, tremor, and dystonia. It is a useful therapeutic option in carefully selected patients that significantly improves motor symptoms, functional status, and quality of life.

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Li, Sheng, Shengai Li, Argyrios Stampas, JoelE Frontera y MatthewE Davis. "New perspective on neuromodulation techniques: Breathing-controlled electrical stimulation as an innovative neuromodulation technique for management of neuropathic pain after spinal cord injury". Journal of the International Society of Physical and Rehabilitation Medicine 3, n.º 4 (2020): 106. http://dx.doi.org/10.4103/jisprm.jisprm_23_20.

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Jarrett, M. "Sacral nerve neuromodulation and fecal incontinence: Indications, technique, and results". Minimally Invasive Therapy & Allied Technologies 13, n.º 5-6 (enero de 2004): 340–46. http://dx.doi.org/10.1080/13645700410007011.

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Janknegt, R. A., E. H. J. Weil y P. H. A. Eerdmans. "Improving neuromodulation technique for refractory voiding dysfunctions: Two-stage implant". Urology 49, n.º 3 (mayo de 1997): 358–62. http://dx.doi.org/10.1016/s0090-4295(96)00506-7.

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Guillaume, S. "La neuromodulation est-elle une technique d’avenir dans la prise en charge des troubles des conduites alimentaires (TCA) ?" European Psychiatry 28, S2 (noviembre de 2013): 20. http://dx.doi.org/10.1016/j.eurpsy.2013.09.049.

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Les techniques de neuromodulation sont de plus en plus utilisées en psychiatrie. Dans le contexte des troubles des conduites alimentaires (TCA) où peu de prises en charge efficaces sont disponibles, plusieurs de ces techniques pourraient avoir un intérêt pour mieux appréhender la physiopathologie et/ou comme thérapie innovante. Trois techniques émergent. Deux sont des techniques de neuromodulation non invasives : la repetitive Transcranial Magnetic Stimulation (rTMS) et la transcranial Direct-Current Stimulation (tDCS) et une nécessite une intervention chirurgicale : la stimulation cérébrale profonde. Dans la boulimie, plusieurs études versus placebo utilisant la rTMS ont montré une diminution des pulsions alimentaires sur du court terme. Nos résultats préliminaires dans une étude multicentrique suggèrent une diminution du nombre de crises dans les 15 jours post-rTMS. La rTMS dans cette population est bien tolérée. Une série d’études pilote suggère également que la tDCS diminue les pulsions et les prises alimentaires et améliore des fonctions cognitives perturbées dans les TCA. Dans l’anorexie, la tolérance de la rTMS a été montrée comme bonne, même chez des patientes à poids très bas. Plusieurs études sont actuellement en cours pour évaluer l’effet sur des fonctions-clés de l’anorexie comme la perception corporelle ou la conscience intéroceptive avec pour objectif essentiel de mieux cerner la physiopathologie. Mais la technique de neuromodulation qui offre le plus d’espoir est la stimulation cérébrale profonde. Deux études pilotes récentes chez des patientes anorexiques très sévères suggèrent non seulement une bonne tolérance mais aussi une amélioration très nette de la symptomatologie alimentaire dans les mois ayant suivi l’intervention. Néanmoins, ces études restent à répliquer et les meilleurs sites et protocoles de stimulation restent à définir. Ainsi, ces techniques suscitent beaucoup d’espoir dans des pathologies résistantes mais leurs efficacités potentielles et utilisation clinique restent encore à définir.

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Hussain, Zahid y Simon C. W. Harrison. "Neuromodulation for Lower Urinary Tract Dysfunction – An Update". Scientific World JOURNAL 7 (2007): 1036–45. http://dx.doi.org/10.1100/tsw.2007.173.

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The aim of this review is to provide an update on the use of neuromodulation using sacral nerve stimulation for the treatment of disorders of the lower urinary tract. Neuromodulation using the InterStim® system (Medtronic Inc.) is now accepted as an established therapeutic option for patients with detrusor overactivity, and for women with retention or severe voiding difficulties. However, the use of nerve stimulation in modulating lower urinary tract function has to be regarded as a technique that is in its infancy. Much has yet to be learned about the mechanism by which neuromodulation exerts its effects and there is a need to better define the clinical indications for the treatment. There is also work to be done in terms of optimising stimulation delivery, both in anatomical and electronic terms.

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Spilotros, Marco, Salvatore Gerbasi, Francesco Lasorsa, Gaetano de Rienzo, Lorenzo Balducci, Pasquale Ditonno y Giuseppe Lucarelli. "Sacral Neuromodulation: Device Improvement and Current Applications in Urology". Medicina 60, n.º 3 (20 de marzo de 2024): 509. http://dx.doi.org/10.3390/medicina60030509.

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Sacral neuromodulation (SNM) offers a therapeutic approach to urological patients suffering from idiopathic overactive bladder (OAB) syndrome, with or without incontinence and non-obstructive urinary retention (NOR), who are not responding to or are not compliant with conservative or medical therapies. The exact mechanism of action of SNM is not fully understood but modulation of the spinal cord reflexes and brain networks by peripheral afferents is regarded as the main pathway. Over the years, surgical techniques improved, leading to the development of the modern two-stage implantation technique. The quadripolar lead is positioned percutaneously under fluoroscopy guidance through the third sacral foramen following the trajectory of S3. The procedure can be performed under local or general anesthesia with the patient in prone position. Current applications of sacral neuromodulation in urology are increasing thanks to the recent improvements of the devices that make this a valuable option not only in conditions such as overactive bladder and non-obstructing urinary retention but also neurogenic lower urinary tract dysfunction.

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Canagasingham, Ashan, James Kovacic, Ioana Popa y Amanda Chung. "Sacral nerve neuromodulation: the past, present and future". Trends in Urology & Men's Health 14, n.º 5 (septiembre de 2023): 30–33. http://dx.doi.org/10.1002/tre.934.

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Exploration and development of electrical stimulation to improve bladder and bowel function began in the early 20th century. The mechanism of action is not fully understood, but refinement and optimisation of the technique may lead to wider use in future.

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Umashankar, Abishek y Prashanth Prabhu. "The application of vagus nerve stimulation in individuals with misophonia". Neuroscience Research Notes 3, n.º 5 (11 de octubre de 2021): 36–43. http://dx.doi.org/10.31117/neuroscirn.v3i5.105.

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Stimulating the Vagus nerve helps maintain the autonomic tone, indicating stabilising any hyperactivity in the nervous system. The vagus nerve stimulation is applied in individuals with seizures, depression, sepsis, pain, obesity, cardiovascular disease, lung disease, diabetes, stroke, and traumatic brain injury. Auditory neuroscience has been widely applied in individuals with tinnitus and has been demonstrated as a successful neuromodulation technique. Individuals with peripheral lesions of the hair cells induce a maladaptive change in the plasticity resulting in hyperactivity in the auditory and non-auditory structures. In order to reduce this hyperactivity, neuromodulation techniques such as; transcranial magnetic stimulation, transcranial direct current stimulation, transcranial alternating current stimulation, transcranial random noise stimulation, neurofeedback, epidural and subdural cortical and deep brain stimulation. The vagus nerve stimulation is also one form of neuromodulation technique considered to reduce the symptoms of tinnitus. It is believed that the ramus Auricularis Nervi vagi, an afferent sensory branch of the vagus nerve, innervates the afferent sensory branch of the vagus nerve, the ramus auricularis nervi vagi also innervate the outer ear canal and parts of the auricle. This auricular branch of the vagus nerve also called Arnold's nerve, which gives a projection to the nucleus of the solitary tract. The vagus nerve stimulation in individuals with tinnitus works to activate the auricular branch of the vagus nerve to reduce its symptoms. A similar principle of vagus nerve stimulation can be tried upon in individuals with misophonia. Literatures states that individuals with misophonia have hyperactivity in their non-classical auditory pathway that can be suppressed with the help of vagus nerve stimulation. The article discusses the possible effects of vagus nerve stimulation in individuals with misophonia.

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Ukueberuwa, Dede y Eric M. Wassermann. "Direct Current Brain Polarization: A Simple, Noninvasive Technique for Human Neuromodulation". Neuromodulation: Technology at the Neural Interface 13, n.º 3 (julio de 2010): 168–73. http://dx.doi.org/10.1111/j.1525-1403.2010.00283.x.

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Karademir, Kenan, Kadir Baykal, Bulent Sen, Temucin Senkul, Cuneyid Iseri y Dogan Erden. "A peripheric neuromodulation technique for curing detrusor overactivity: Stoller afferent neurostimulation". Scandinavian Journal of Urology and Nephrology 39, n.º 3 (mayo de 2005): 230–33. http://dx.doi.org/10.1080/00365590510031147.

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Chu, Po-Chun, Chen-Syuan Huang, Pi-Kai Chang, Rou-Shayn Chen, Ko-Ting Chen, Tsung-Hsun Hsieh y Hao-Li Liu. "Weak Ultrasound Contributes to Neuromodulatory Effects in the Rat Motor Cortex". International Journal of Molecular Sciences 24, n.º 3 (30 de enero de 2023): 2578. http://dx.doi.org/10.3390/ijms24032578.

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Transcranial focused ultrasound (tFUS) is a novel neuromodulating technique. It has been demonstrated that the neuromodulatory effects can be induced by weak ultrasound exposure levels (spatial-peak temporal average intensity, ISPTA < 10 mW/cm2) in vitro. However, fewer studies have examined the use of weak tFUS to potentially induce long-lasting neuromodulatory responses in vivo. The purpose of this study was to determine the lower-bound threshold of tFUS stimulation for inducing neuromodulation in the motor cortex of rats. A total of 94 Sprague–Dawley rats were used. The sonication region aimed at the motor cortex under weak tFUS exposure (ISPTA of 0.338–12.15 mW/cm2). The neuromodulatory effects of tFUS on the motor cortex were evaluated by the changes in motor-evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS). In addition to histology analysis, the in vitro cell culture was used to confirm the neuromodulatory mechanisms following tFUS stimulation. In the results, the dose-dependent inhibitory effects of tFUS were found, showing increased intensities of tFUS suppressed MEPs and lasted for 30 min. Weak tFUS significantly decreased the expression of excitatory neurons and increased the expression of inhibitory GABAergic neurons. The PIEZO-1 proteins of GABAergic neurons were found to involve in the inhibitory neuromodulation. In conclusion, we show the use of weak ultrasound to induce long-lasting neuromodulatory effects and explore the potential use of weak ultrasound for future clinical neuromodulatory applications.

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Tsui, Ban C. H. y Rajnish K. Gupta. "Role of neuromodulation in acute pain settings". Regional Anesthesia & Pain Medicine 48, n.º 6 (20 de abril de 2023): 338–42. http://dx.doi.org/10.1136/rapm-2022-103837.

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Peripheral nerve stimulation (PNS), a type of neuromodulatory technique, is increasingly used to treat chronic pain syndromes. PNS has also recently gained popularity as a viable adjunct analgesic modality in acute pain settings, where the practice primarily relies on using boluses or infusion of local anesthetics for nerve blockade, followed by stimulation to extend the analgesia. There is some early promise in PNS for perioperative analgesic control, but considerable obstacles must be addressed before it can be implemented into standard practice. In this daring discourse, we explore the possibilities and constraints of using the PNS paradigm in acute pain.

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Claes, Marie, Lies De Groef y Lieve Moons. "The DREADDful Hurdles and Opportunities of the Chronic Chemogenetic Toolbox". Cells 11, n.º 7 (25 de marzo de 2022): 1110. http://dx.doi.org/10.3390/cells11071110.

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The chronic character of chemogenetics has been put forward as one of the assets of the technique, particularly in comparison to optogenetics. Yet, the vast majority of chemogenetic studies have focused on acute applications, while repeated, long-term neuromodulation has only been booming in the past few years. Unfortunately, together with the rising number of studies, various hurdles have also been uncovered, especially in relation to its chronic application. It becomes increasingly clear that chronic neuromodulation warrants caution and that the effects of acute neuromodulation cannot be extrapolated towards chronic experiments. Deciphering the underlying cellular and molecular causes of these discrepancies could truly unlock the chronic chemogenetic toolbox and possibly even pave the way for chemogenetics towards clinical application. Indeed, we are only scratching the surface of what is possible with chemogenetic research. For example, most investigations are concentrated on behavioral read-outs, whereas dissecting the underlying molecular signature after (chronic) neuromodulation could reveal novel insights in terms of basic neuroscience and deregulated neural circuits. In this review, we highlight the hurdles associated with the use of chemogenetic experiments, as well as the unexplored research questions for which chemogenetics offers the ideal research platform, with a particular focus on its long-term application.

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Al-Shaiji, Tariq F., Mai Banakhar y Magdy M. Hassouna. "Pelvic Electrical Neuromodulation for the Treatment of Overactive Bladder Symptoms". Advances in Urology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/757454.

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Overactive bladder syndrome negatively affects the daily life of many people. First-line conservative treatments, such as antimuscarinics, do not always lead to sufficient improvement of the complaints and/or are often associated with disabling adverse effects leading to treatment failure. Electrical stimulation of the sacral nerves has emerged as an alternative and attractive treatment for refractory cases of bladder overactivity. Few theories attempted to explain its mechanism of action which remains elusive. It involves percutaneous posterior tibial nerve stimulation and more commonly sacral neuromodulation. For the latter, temporary sacral nerve stimulation is the first step. If the test stimulation is successful, a permanent device is implanted. The procedure is safe and reversible. It carries a durable success rate. The technique should be combined with careful followup and attentive adjustments of the stimulation parameters in order to optimize the clinical outcomes. This paper provides a review on the indications, possible mechanisms of action, surgical aspects and possible complications, and safety issues of this technique. The efficacy of the technique is also addressed.

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Moraes, Fernanda Vieira, Sandra de Fátima Barboza Ferreira, Ângela Maria Costa De Souza y Denise Sisterolli Diniz. "Neuromodulation Using Transcranial Magnetic Stimulation (TMS)". JBNC - JORNAL BRASILEIRO DE NEUROCIRURGIA 27, n.º 2 (16 de marzo de 2018): 149–54. http://dx.doi.org/10.22290/jbnc.v27i2.771.

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Introduction: TMS is said to be an effective technique for motor and cognitive rehabilitation for acquired neurological lesions. This study aims to evaluate the effect of TMS in the cognition of patients after stroke. Methods: This prospective, longitudinal and interventional study was approved by the Ethics Committee (Protocol No. 54977216.3.0000.5078) and included 16 stroke victims aged from 24 to 74 years. The Montreal Cognitive Assessment (MoCA) test was used before and after the stimulation sessions and TMS was administered according to treatment protocols for a motor goal, with inhibitory (1 hz) TMS stimulation over the right and left primary motor cortex; and according to protocol for the prefrontal cortex involved in humor processing, with stimulation (10 hz) of the left dorsolateral prefrontal cortex, and inhibitory (1 hz) stimulation of the right dorsolateral prefrontal cortex. The patients underwent fifteen treatment sessions, on average. Results: Memory subtests showed improvement, and average and standard deviation values for the pre- and post-intervention periods were [2.06 (1.6) and 3.5 (1.5)], respectively. In terms of total performance, MoCA results were [18.7(3.4) and 21.1(4.03)]. Student’s t test indicated p=0.006 for performance differences in memory and p=0.003 for total performance. Conclusion: TMS was shown to be effective in achieving cognitive rehabilitation after strokes, most notably in terms of the recovery of mnemonic functions

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Sammartino, Francesco, John Snell, Matthew Eames y Vibhor Krishna. "Thermal Neuromodulation With Focused Ultrasound: Implications for the Technique of Subthreshold Testing". Neurosurgery 89, n.º 4 (9 de julio de 2021): 610–16. http://dx.doi.org/10.1093/neuros/nyab238.

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Abstract BACKGROUND During focused ultrasound ablation (FUSA), the presumed stereotactic target is tested with subthreshold sonications before permanent ablation. This testing relies on ultrasound-induced reversible clinical effects (thermal neuromodulation, TN). However, the thermal dose and spot size thresholds to induce TN are not yet defined. OBJECTIVE To define the thermal dose and spot size thresholds associated with TN. METHODS We performed a retrospective analysis of intraoperative FUSA data of essential tremor patients. Sonications with a thermal dose of less than 25 cumulative equivalent minutes (CEM) were classified as subthreshold. The intraoperative writing samples were independently rated by 2 raters using the clinical rating scale for tremor. The association between thermal dose and tremor scores was statistically analyzed, and the thermal dose and spot size thresholds for TN were computed using leave-one-out cross-validation analysis. RESULTS A total of 331 pairs of sonications and writing samples were analyzed; 97 were classified as subthreshold sonications. TN was observed in 23 (24%) subthreshold sonications. The median tremor improvement during TN was 20% (interquartile range = 41.6). The thermal dose threshold for TN was 0.67 CEM (equivalent to 30 s thermal exposure at 43°C). The spot size threshold for TN was 2.46 mm. Ventral intermediate medial nucleus was exposed to TN thermal dose during subablative and ablative sonications. CONCLUSION The TN thermal dose and spot size thresholds are significantly higher than the current FUSA standard of care. We recommend long duration (>30 s), subthreshold sonications for intraoperative testing during FUSA. Future investigations should test whether the thermal dose threshold is tissue-specific and determine the mechanisms underlying focused ultrasound TN.

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Theodosiadis, Panos, Vasilios Grosomanidis, Efthimios Samoladas y Byron E. Chalidis. "Subcutaneous targeted neuromodulation technique for the treatment of intractable chronic postthoracotomy pain". Journal of Clinical Anesthesia 22, n.º 8 (diciembre de 2010): 638–41. http://dx.doi.org/10.1016/j.jclinane.2009.10.018.

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Marangolo, Paola y Francesca Pisano. "Conversational Therapy in Aphasia: From Behavioral Intervention to Neuromodulation". Seminars in Speech and Language 41, n.º 01 (23 de diciembre de 2019): 061–70. http://dx.doi.org/10.1055/s-0039-3399500.

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AbstractThis article describes the conversational therapy approach for the treatment of persons with aphasia (PWAs). Around 1970s, this approach was inspired by a series of pragmatic principles and techniques to aphasia rehabilitation whose main objective was to set up a condition of communicative exchange with the PWA using his/her own available communicative resources. Indeed, although language represents the most powerful behavior that humans use for communicating, within the conversational approach any intentional action (i.e., gestures, body movements, facial expression, drawing) can be used to communicate. For this reason, its application is particularly suitable for severe PWAs whose damage has compromised all the modalities of language (i.e., production, comprehension, reading, and writing). In this perspective, the speech-language pathologist's (SLP's) goal is not necessarily focused on restoring the damaged linguistic functions, still today pursued by the cognitive approach, but to ameliorate the use of language by teaching the PWA compensatory, productive strategies, and strengthening his/her residual communicative abilities. In this review, the fundamental principles of the conversational approach together with its modalities of treatment, which emphasize the importance of an active interaction between the SLP and the PWA, are reported. A brief summary of recent experimental evidence which combines conversational therapy with a noninvasive brain stimulation technique, transcranial direct current stimulation, is also included.

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Burd, S. G., A. V. Lebedeva, G. G. Avakyan, Yu V. Rubleva, I. V. Senko, N. V. Pantina, A. V. Yurchenko y I. I. Kovaleva. "Application of focused ultrasound in the treatment of epilepsy". Epilepsy and paroxysmal conditions 14, n.º 3 (17 de octubre de 2022): 294–303. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2022.120.

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The high prevalence of pharmacoresistant epilepsy requires the use of nonpharmacological, including surgical approaches to the treatment of this disease. The surgical methods currently used to treat epilepsy (resection, stimulation, and disconnection) carry certain risks of developing intra- and postoperative complications. The technique of magnetic resonance-guided focused ultrasound (MRgFUS) may be an alternative to traditional neurosurgical interventions. Currently, MRgFUS is successfully used in the treatment of essential tremor and Parkinson’s tremor. As the literature data show, the use of focused ultrasound is a promising method in the treatment of epilepsy. It has been reported about successful FUS application for neuromodulation in animal epilepsy models. Studies related to FUS ablation of epileptogenic foci, neuromodulation in humans with epilepsy are currently underway. The technique of locally increased permeability of the blood-brain barrier after FUS, used for the treatment of brain oncological diseases and neurodegenerative disorders is also of interest in the targeted delivery of antiepileptic drugs. However, some experimental works are contradictory, and the lack of large-scale studies of MRgFUS in patients with epilepsy requires further investigation of this technique and its effectiveness.

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Velasco, Ana Luisa. "Developments in Neurostimulation Therapy for Epilepsy". US Neurology 05, n.º 02 (2010): 78. http://dx.doi.org/10.17925/usn.2010.05.02.78.

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Neuromodulating neural tissue instead of performing lesions is a current trend in neurosurgery. In the case of epilepsy, stimulation of the nervoussystem is under investigation, and the field is growing at a fast pace. The purpose of this article is to review the various targets that have been studiedin the search for a way to control refractory seizures. Consideration is made of why each target is chosen, patient selection, results, and adverseeffects. Cerebellar stimulation was the first proposed method; vagus nerve stimulation is currently the most widely used due to its easy technique,but the results on seizure reduction are modest. Other targets were chosen with the idea of interfering with seizure propagationthis is the casewith thalamic stimulation. Currently, studies are being performed stimulating the epileptic focus. Although there are still many controversiesregarding which is the best target and stimulating parameters, all authors agree that neuromodulation reduces seizures and has the advantage ofbeing reversible and safe.

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40

Velasco, Ana Luisa. "Developments in Neurostimulation Therapy for Epilepsy". European Neurological Review 4, n.º 2 (2009): 88. http://dx.doi.org/10.17925/enr.2009.04.02.88.

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Neuromodulating neural tissue instead of performing lesions is a current trend in neurosurgery. In the case of epilepsy, stimulation of the nervous system is under investigation, and the field is growing at a fast pace. The purpose of this article is to review the various targets that have been studied in the search for a way to control refractory seizures. Consideration is made of why each target is chosen, patient selection, results and adverse effects. Cerebellar stimulation was the first proposed method; vagus nerve stimulation is currently the most widely used due to its easy technique, but the results on seizure reduction are modest. Other targets were chosen with the idea of interfering with seizure propagation – this is the case with thalamic stimulation. Currently, studies are being performed stimulating the epileptic focus. Although there are still many controversies regarding which is the best target and stimulating parameters, all authors agree that neuromodulation reduces seizures and has the advantage of being reversible and safe.

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Smith, Benjamin J. H., Chakravarthini M. Saaj y Elie Allouis. "ANUBIS: Artificial Neuromodulation Using a Bayesian Inference System". Neural Computation 25, n.º 1 (enero de 2013): 221–58. http://dx.doi.org/10.1162/neco_a_00376.

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Gain tuning is a crucial part of controller design and depends not only on an accurate understanding of the system in question, but also on the designer's ability to predict what disturbances and other perturbations the system will encounter throughout its operation. This letter presents ANUBIS (artificial neuromodulation using a Bayesian inference system), a novel biologically inspired technique for automatically tuning controller parameters in real time. ANUBIS is based on the Bayesian brain concept and modifies it by incorporating a model of the neuromodulatory system comprising four artificial neuromodulators. It has been applied to the controller of EchinoBot, a prototype walking rover for Martian exploration. ANUBIS has been implemented at three levels of the controller; gait generation, foot trajectory planning using Bézier curves, and foot trajectory tracking using a terminal sliding mode controller. We compare the results to a similar system that has been tuned using a multilayer perceptron. The use of Bayesian inference means that the system retains mathematical interpretability, unlike other intelligent tuning techniques, which use neural networks, fuzzy logic, or evolutionary algorithms. The simulation results show that ANUBIS provides significant improvements in efficiency and adaptability of the three controller components; it allows the robot to react to obstacles and uncertainties faster than the system tuned with the MLP, while maintaining stability and accuracy. As well as advancing rover autonomy, ANUBIS could also be applied to other situations where operating conditions are likely to change or cannot be accurately modeled in advance, such as process control. In addition, it demonstrates one way in which neuromodulation could fit into the Bayesian brain framework.

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Magotra, Arjun y Juntae Kim. "Neuromodulated Dopamine Plastic Networks for Heterogeneous Transfer Learning with Hebbian Principle". Symmetry 13, n.º 8 (26 de julio de 2021): 1344. http://dx.doi.org/10.3390/sym13081344.

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The plastic modifications in synaptic connectivity is primarily from changes triggered by neuromodulated dopamine signals. These activities are controlled by neuromodulation, which is itself under the control of the brain. The subjective brain’s self-modifying abilities play an essential role in learning and adaptation. The artificial neural networks with neuromodulated plasticity are used to implement transfer learning in the image classification domain. In particular, this has application in image detection, image segmentation, and transfer of learning parameters with significant results. This paper proposes a novel approach to enhance transfer learning accuracy in a heterogeneous source and target, using the neuromodulation of the Hebbian learning principle, called NDHTL (Neuromodulated Dopamine Hebbian Transfer Learning). Neuromodulation of plasticity offers a powerful new technique with applications in training neural networks implementing asymmetric backpropagation using Hebbian principles in transfer learning motivated CNNs (Convolutional neural networks). Biologically motivated concomitant learning, where connected brain cells activate positively, enhances the synaptic connection strength between the network neurons. Using the NDHTL algorithm, the percentage of change of the plasticity between the neurons of the CNN layer is directly managed by the dopamine signal’s value. The discriminative nature of transfer learning fits well with the technique. The learned model’s connection weights must adapt to unseen target datasets with the least cost and effort in transfer learning. Using distinctive learning principles such as dopamine Hebbian learning in transfer learning for asymmetric gradient weights update is a novel approach. The paper emphasizes the NDHTL algorithmic technique as synaptic plasticity controlled by dopamine signals in transfer learning to classify images using source-target datasets. The standard transfer learning using gradient backpropagation is a symmetric framework. Experimental results using CIFAR-10 and CIFAR-100 datasets show that the proposed NDHTL algorithm can enhance transfer learning efficiency compared to existing methods.

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Gupta, Mayank. "Transverse Abdominal Plane Neurostimulation for Chronic Abdominal Pain: A Novel Technique". Pain Physician 5;17, n.º 5;9 (14 de septiembre de 2014): E619—E622. http://dx.doi.org/10.36076/ppj.2014/17/e619.

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Management of chronic abdominal pain can be challenging. Sometimes patients fail to get adequate response from multiple medications and nerve blocks. We present a patient case report of chronic abdominal pain with a history of multiple surgeries managed successfully by neuromodulation of the transverse abdominis plane (TAP). The TAP block is a procedure in which local anesthetic is injected into the abdominal fascial plane that carries sensory nerves to the abdominal wall in order to block pain sensation. It has been shown to reduce postoperative pain and analgesic dependence after abdominal and gynecological surgeries. A 60-year-old woman presented to us for chronic abdominal pain for which medications provided little relief. She had an extensive history of abdominal surgeries and was also treated for lower back pain with surgery and less invasive procedures in the past. Under our care, she underwent 2 TAP blocks with almost complete resolution of her abdominal pain. Her pain, however, came back within a few of weeks of the procedures. Since our patient found pain relief from the TAP blocks, we proceeded with neurostimulation of the TAP for long-term pain relief. We placed a dorsal column stimulator 16 contact lead for lower back and leg pain and 8 contact leads placed in the TAP under ultrasound guidance. She has had multiple follow-ups since her TAP lead placement procedure with continued and near complete resolution of her abdominal pain. The TAP lead stimulation was helping her abdominal pain and the dorsal column lead stimulation was helping her back and leg pain. Key words: Chronic abdominal pain, neuromodulation, transverse abdominis plane, ultrasound, transverse abdominis plane block, multiple abdominal surgeries

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Shaparin, Naum, Karina Gritsenko, Diego Fernandez Garcia-Roves, Ushma Shah, Todd Schultz y Oscar DeLeon-Casasola. "Peripheral neuromodulation for the treatment of refractory trigeminal neuralgia". Pain Research and Management 20, n.º 2 (2015): 63–66. http://dx.doi.org/10.1155/2015/482652.

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Trigeminal neuralgia is a type of orofacial pain that is diagnosed in 150,000 individuals each year, with an incidence of 12.6 per 100,000 person-years and a prevalence of 155 cases per 1,000,000 in the United States. Trigeminal neuralgia pain is characterized by sudden, severe, brief, stabbing or lancinating, recurrent episodes of pain in the distribution of one or more branches of the trigeminal nerve, which can cause significant suffering for the affected patient population.In many patients, a combination of medication and interventional treatments can be therapeutic, but is not always successful. Peripheral nerve stimulation has gained popularity as a simple and effective neuromodulation technique for the treatment of many pain conditions, including chronic headache disorders. Specifically in trigeminal neuralgia, neurostimulation of the supraorbital and infraorbital nerves may serve to provide relief of neuropathic pain by targeting the distal nerves that supply sensation to the areas of the face where the pain attacks occur, producing a field of paresthesia within the peripheral distribution of pain through the creation of an electric field in the vicinity of the leads.The purpose of the present case report is to introduce a new, less-invasive interventional technique, and to describe the authors’ first experience with supraorbital and infraorbital neurostimulation therapy for the treatment of trigeminal neuralgia in a patient who had failed previous conservative management.

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DeJulio, Paul A., Christopher J. Yih, Timothy M. Dang y Rajiv D. Reddy. "Basal Cell Carcinoma Formation Within A Spinal Cord Stimulator Surgical Scar: A Case Report". A&A Practice 18, n.º 4 (abril de 2024): e01783. http://dx.doi.org/10.1213/xaa.0000000000001783.

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Implanting neuromodulation devices requires that pain medicine physicians be well-versed in proper surgical technique and postoperative wound management. To be able to identify abnormal wound healing, a basic understanding of normal wound healing is required. When postoperative wounds deviate from expected healing, it is important that pain medicine physicians entertain a broad differential diagnosis, including nonsurgical dermatologic pathology.

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Talbot, Christopher, Kevin Zhao, Antonios Mammis y Boris Paskhover. "O116 / #219 NEUROMODULATION OF THE LINGUAL NERVE: A NOVEL TECHNIQUE AND CASE SERIES". Neuromodulation: Technology at the Neural Interface 25, n.º 7 (octubre de 2022): S142. http://dx.doi.org/10.1016/j.neurom.2022.08.154.

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Dario, A., E. Borsani, M. Protasoni, M. Reguzzoni, C. Reverberi, S. Sangiorgi, G. Tomei y L. Rodella. "170 PULSED RADIOFREQUENCY IMPROVES EXPERIMENTAL NEUROPATHIC PAIN BUT IS NOT A NEUROMODULATION TECHNIQUE". European Journal of Pain Supplements 4, S1 (abril de 2010): 51. http://dx.doi.org/10.1016/s1754-3207(10)70175-9.

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Peters, Kenneth M., Jeffrey M. Carey y David B. Konstandt. "Sacral neuromodulation for the treatment of refractory interstitial cystitis: outcomes based on technique". International Urogynecology Journal and Pelvic Floor Dysfunction 14, n.º 4 (1 de octubre de 2003): 223–28. http://dx.doi.org/10.1007/s00192-003-1070-3.

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Adelstein, Sarah A., Wai Lee, Kevin Gioia, Dena Moskowitz, Kelsey Stamnes, Alvaro Lucioni, Kathleen C. Kobashi y Una J. Lee. "Outcomes in a contemporary cohort undergoing sacral neuromodulation using optimized lead placement technique". Neurourology and Urodynamics 38, n.º 6 (mayo de 2019): 1595–601. http://dx.doi.org/10.1002/nau.24018.

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Waataja, Jonathan J., Anders J. Asp y Charles J. Billington. "Combining Celiac and Hepatic Vagus Nerve Neuromodulation Reverses Glucose Intolerance and Improves Glycemic Control in Pre- and Overt-Type 2 Diabetes Mellitus". Biomedicines 11, n.º 9 (4 de septiembre de 2023): 2452. http://dx.doi.org/10.3390/biomedicines11092452.

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Neurological disorders and type 2 diabetes mellitus (T2DM) are deeply intertwined. For example, autonomic neuropathy contributes to the development of T2DM and continued unmanaged T2DM causes further progression of nerve damage. Increasing glycemic control has been shown to prevent the onset and progression of diabetic autonomic neuropathies. Neuromodulation consisting of combined stimulation of celiac vagal fibers innervating the pancreas with concurrent electrical blockade of neuronal hepatic vagal fibers innervating the liver has been shown to increase glycemic control in animal models of T2DM. The present study demonstrated that the neuromodulation reversed glucose intolerance in alloxan-treated swine in both pre- and overt stages of T2DM. This was demonstrated by improved performance on oral glucose tolerance tests (OGTTs), as assessed by area under the curve (AUC). In prediabetic swine (fasting plasma glucose (FPG) range: 101–119 mg/dL) the median AUC decreased from 31.9 AUs (IQR = 28.6, 35.5) to 15.9 AUs (IQR = 15.1, 18.3) p = 0.004. In diabetic swine (FPG range: 133–207 mg/dL) the median AUC decreased from 54.2 AUs (IQR = 41.5, 56.6) to 16.0 AUs (IQR = 15.4, 21.5) p = 0.003. This neuromodulation technique may offer a new treatment for T2DM and reverse glycemic dysregulation at multiple states of T2DM involved in diabetic neuropathy including at its development and during progression.

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