Literatura académica sobre el tema "Tcaf"

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Artículos de revistas sobre el tema "Tcaf"

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Milanese, C., R. F. Siliciano, R. E. Schmidt, J. Ritz, N. E. Richardson y E. L. Reinherz. "A lymphokine that activates the cytolytic program of both cytotoxic T lymphocyte and natural killer clones." Journal of Experimental Medicine 163, n.º 6 (1 de junio de 1986): 1583–88. http://dx.doi.org/10.1084/jem.163.6.1583.

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A 10-12 kD lymphokine, herein termed TCAF, was recently shown to be secreted from Th after crosslinking of their antigen/MHC (T3-Ti) receptors. TCAF stimulates resting T lymphocyte proliferation via binding to surface components of the T11 pathway. To determine whether TCAF could induce antigen-independent activation of the lytic machinery of cytotoxic cells, the present studies were conducted. In the presence of TCAF, both T8+ class I MHC-specific and T4+ class II MHC-specific cytotoxic T cell clones were induced to kill targets, including those lacking the appropriate MHC molecules. This effect was unique to TCAF, since IL-1, IL-2, IFN-gamma could not stimulate lytic activity. Furthermore, both T3+T11+ and T3-T11+ NK clones were triggered to lyse NK-resistant target cells. These findings suggest that TCAF can function in an antigen-independent fashion to amplify cytotoxic effector responses.
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Sulaiman, Raed, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Kris Gaster, Luis Rojas Espaillat, David Starks y Nandini Dey. "A CAF-Based Two-Cell Hybrid Co-Culture Model to Test Drug Resistance in Endometrial Cancers". Biomedicines 11, n.º 5 (29 de abril de 2023): 1326. http://dx.doi.org/10.3390/biomedicines11051326.

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The management of advanced or recurrent endometrial cancers presents a challenge due to the development of resistance to treatments. The knowledge regarding the role of the tumor microenvironment (TME) in determining the disease’s progression and treatment outcome has evolved in recent years. As a TME component, cancer-associated fibroblasts (CAFs) are essential in developing drug-induced resistance in various solid tumors, including endometrial cancers. Hence, an unmet need exists to test the role of endometrial CAF in overcoming the roadblock of resistance in endometrial cancers. We present a novel tumor–TME two-cell ex vivo model to test CAF’s role in resisting the anti-tumor drug, paclitaxel. Endometrial CAFs, both NCAFs (tumor-adjacent normal-tissue-derived CAFs) and TCAFs (tumor-tissue-derived CAFs) were validated by their expression markers. Both TCAFs and NCAFs expressed positive markers of CAF, including SMA, FAP, and S100A4, in varying degrees depending on the patients, while they consistently lacked the negative marker of CAF, EpCAM, as tested via flow cytometry and ICC. CAFs expressed TE-7 and immune marker, PD-L1, via ICC. CAFs better resisted the growth inhibitory effect of paclitaxel on endometrial tumor cells in 2D and 3D formats compared to the resistance of the tumoricidal effect of paclitaxel in the absence of CAFs. TCAF resisted the growth inhibitory effect of paclitaxel on endometrial AN3CA and RL-95-2 cells in an HyCC 3D format. Since NCAF similarly resisted the growth inhibitor action of paclitaxel, we tested NCAF and TCAF from the same patient to demonstrate the protective action of NCAF and TCAF in resisting the tumoricidal effect of paclitaxel in AN3CA in both 2D and 3D matrigel formats. Using this hybrid co-culture CAF and tumor cells, we established a patient-specific, laboratory-friendly, cost-effective, and time-sensitive model system to test drug resistance. The model will help test the role of CAFs in developing drug resistance and contribute to understanding tumor cell-CAF dialogue in gynecological cancers and beyond.
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Bulitta, Clemens, Sergeii Vasiuk, Yaroslav Vasylchyshyn, Volodymyr Vasyuk, Regina Guttenberger y Sebastian Buhl. "Clinical validation and efficacy of a temperature-controlled ventilation system (TcAF) in the OR to reduce surgical site infections". Current Directions in Biomedical Engineering 6, n.º 3 (1 de septiembre de 2020): 301–3. http://dx.doi.org/10.1515/cdbme-2020-3077.

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AbstractMicrobiological burden of room-air in operating theatres is a known risk factor for surgical site infections. However, it is unclear how to best evaluate efficacy and efficiency under routine clinical conditions. Moreover, there still is a lack of data to assess the impact on infection rates. The aim of this study was to evaluate a temperature-controlled ventilation system (TcAF) under routine clinical conditions and assess its impact on infection rates. 10 clinical installations of the TcAF system Opragon (Avidicare AB, Sweden) were assessed during live surgeries according to the Swedish SIS TS 39: 2015 standard. Furthermore, a retrospective analysis of 1,000 consecutive cases of primary total joint arthroplasty (hip, knee) before and 1000 after installation of the TcAF system was performed. Endpoints for clinical outcome were length of stay and infection rates. Our results show that requirements of the Swedish standard were met or significantly exceeded by the TcAF system reliably and robustly ensuring "ultra-clean" air in the entire operating theatre and demonstrating the capability to reduce the risk of airborne microbial transmission under routine clinical conditions. The study shows positive impact on key clinical outcome parameters in line with previous research by Charnley and Lidwell.
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Ramos, Solange de Paula, Vanessa Batista da Costa Santos, Roberto José Ruiz, Maria Carla Perozim Preti, Mayara Caroline Ventura, Maiara Santos Nogueira, Francelaine Bruna Campana, Sérgio Swain Müller, Marcos Doederlein Polito y Claudia Patrícia Cardoso Martins Siqueira. "Efeito do treinamento físico e da ingestão crônica de cafeína sobre o tecido ósseo de ratos jovens". Revista Brasileira de Educação Física e Esporte 26, n.º 2 (junio de 2012): 209–17. http://dx.doi.org/10.1590/s1807-55092012000200004.

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Foram avaliados os efeitos da ingestão crônica de cafeína e exercício de natação sobre o tecido ósseo. Ratos Wistar jovens (n = 32) alocados em quatro grupos: sedentário controle (SCO), sedentário + cafeína (SCAF), treinados (TCO) e treinados + cafeína (TCAF), receberam 1 mg/ml de cafeína em água durante 30 dias (SCAF e TCAF) e foram submetidos a 21 dias de natação em intensidade moderada (TCO e TCAF). A tíbia esquerda foi submetida a ensaio biomecânico para determinação do coeficiente de rigidez, limite de elasticidade e carga máxima. A área de tecido ósseo primário e espessura do disco epifisário foram avaliadas no fêmur. Não foram observadas alterações nas propriedades biomecânicas e na deposição de tecido ósseo primário. O grupo SCAF apresentou maior espessura no disco epifisário distal. Os resultados sugerem que o treinamento moderado de natação e a ingestão de cafeína não provocaram alterações morfológicas e biomecânicas do tecido ósseo.
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Ma, Xiangyang, Binbin Wang, Yuyue Chen, Su Ge, Xiaobao Zou, Shuang Zhang y Hong Xia. "Outcome of Thoracic Column Antedisplacement and Fusion in Treatment of Thoracic Myelopathy Caused by Ossification of Posterior Longitudinal Ligament: A Case Series Study". Operative Neurosurgery 21, n.º 3 (7 de junio de 2021): 118–25. http://dx.doi.org/10.1093/ons/opab193.

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Abstract BACKGROUND Up to date, surgical outcome of multilevel thoracic ossification of posterior longitudinal ligament (T-OPLL) with high canal occupation ratio is less satisfactory. OBJECTIVE To explore the result of thoracic column antedisplacement and fusion (TCAF) in treatment of multilevel T-OPLL with high canal occupation ratio. METHODS A total of 5 patients who underwent TCAF procedure for T-OPLL were retrospectively reviewed. Parameters including extent of OPLL, thickness of the maximal OPLL (max-OPLL), maximal canal occupying ratio (max-COR) of OPLL, effective canal diameter (ECD) at the max-OPLL level, antedisplacement distance of thoracic columns, ASIA grades, Japanese Orthopedic Association (JOA) scores, and complications were collected and analyzed at preoperation and the last follow-up. RESULTS All patients (5 F, mean age 61.0 yr, mean follow-up 18.0 months) underwent TCAF successfully and no spinal cord injury or cerebrospinal fluid leakage occurred. The mean extent of OPLL was 2.8 vertebral bodies. The mean preoperative thickness of the max-OPLL was 5.9 mm. The average antedisplacement distance of thoracic columns was 5.6 mm. The mean ECD was improved from 6.5 mm to 10.9 mm, and the max-COR was improved from 50.7% to 7.1% at last follow-up. Two patients showed improvement in ASIA grades and JOA scores were significantly improved from 5.6 points to 10.4 points at final follow-up. The overall therapeutic results of 1 patient were classified into good and 4 into fair at last follow-up. CONCLUSION TCAF may be a safe and effective procedure in treatment of multilevel T-OPLL with high canal occupation ratio.
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Ruiz, Roberto, Solange de Paula Ramos, Marli Martins Pinge, Solange Franzói de Moraes y Marcos Polito. "Caffeine and physical training: effects on cardiac morphology and cardiovascular response". Revista da Associação Médica Brasileira 60, n.º 1 (febrero de 2014): 23–28. http://dx.doi.org/10.1590/1806-9282.60.01.007.

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Objective to analyze the morphological structure of cardiac, blood pressure (BP), heart rate (HR) and heart rate variability (HRV) of rats subjected to physical training with supplementation of caffeine. Methods 60 rats were divided into 4 groups: control (CO), control with caffeine (CAF), trained control (TRE) and trained with caffeine (TCAF). All trained groups underwent 4 weeks of swimming, and all caffeine groups were supplemented by voluntary ingestion of caffeine diluted in drinking water. Results there were no changes to BP and HR between groups. Regarding HRV, there was a decrease in LFnorm (low frequency) and LF/HF ratio (low and high frequency) in TCAF and CAF compared to group (p<0.02 and p<0.03, respectively). An increase occurred in CAF compared to the CO in the component LFnorm (p<0.05). The results also showed an increase in the relative weight of heart in the TRE (p<0.04) and TCAF (p<0.03) compared to CO. Conclusion caffeine did not modify the hemodynamic responses. However, physical training resulted in a decrease in sympathetic response and an increase in relative heart weight.
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Chatterjee, Kaushik, Dipak Debnath, Sujoy Kumar Nath y Hsiang-Kuang Chang. "MAXI J0637–430: A Possible Candidate for Bulk Motion Comptonization?" Astrophysical Journal 956, n.º 1 (1 de octubre de 2023): 55. http://dx.doi.org/10.3847/1538-4357/acf463.

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Abstract The transient Galactic black hole candidate MAXI J0637–430 went through an outburst in 2019–2020 for the very first time. This outburst was active for almost 6 months from 2019 November to 2020 May. We study the spectral properties of this source during that outburst using archival data from NICER/XTI, Swift/XRT, and NuSTAR/FPM satellites/instruments. We have analyzed the source during six epochs on which simultaneous NICER–NuSTAR and Swift/XRT–NuSTAR data were available. Using both phenomenological and physical model fitting approaches, we analyzed the spectral data in the broad 0.7–70 keV energy band. We first used a combination of disk blackbody with power-law, disk blackbody with broken power-law, and disk blackbody with power-law and bulk motion Comptonization (BMC) models. For a better understanding of the accretion picture, e.g., understanding how the accretion rates change with the changing size of the perceived Compton cloud, we used the two-component advective flow (TCAF) model with the broken power-law, and TCAF with the combined power-law, BMC models. For the last three epochs, the diskbb+power-law and TCAF models were able to spectrally fit the data for acceptable χ 2/degrees of freedom (dof). However, for the first three epochs, we needed an additional component to fit spectra for acceptable χ 2/dof. From our analysis, we reported on the possible presence of another component during these first three epochs when the source was in the high soft state. This additional component in this state is best described by the BMC phenomenon. From the TCAF model fitting, we estimated the average mass of the source as 8.1 − 2.7 + 1.3 M ⊙ .
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Debnath, Dipak, Kaushik Chatterjee, Debjit Chatterjee, Arghajit Jana y Sandip K. Chakrabarti. "Jet properties of XTE J1752−223 during its 2009–2010 outburst". Monthly Notices of the Royal Astronomical Society 504, n.º 3 (28 de abril de 2021): 4242–51. http://dx.doi.org/10.1093/mnras/stab1169.

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ABSTRACT Galactic short orbital period black hole candidate (BHC) XTE J1752−223 was discovered on 2009 October 21 by the Rossi X-ray Timing Explorer (RXTE). We study the spectral properties of this outburst using transonic flow solution based two component advective flow (TCAF) model. TCAF model fitted spectrum gives an estimation of the physical flow parameters, such as the Keplerian disc rate, sub-Keplerian halo rate, properties of the so-called Compton cloud, other than the mass of the source and normalization (N). N is a standardized ratio of emitted to observed photon flux in TCAF that does not include X-ray emission from jets. In the presence of jets, this ratio changes and this deviation is used to obtain the estimation of X-ray contribution from the jets. Nature of the jet is found to be compact during low luminous hard state and discrete or blobby during high luminous intermediate states. We find a correlation between the radio (5.5 GHz) and X-ray (2.5–25 keV) fluxes from different components. The radio (FR) and jet X-ray (Fouf) fluxes are found to be correlated within the acceptable range of the standard correlation (0.6 to 0.7). A similar correlation indices were reported by our group for three other short orbital period transient BHCs (Swift J1753.5−0127, MAXI J1836−194, and XTE J1118+480).
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Sautreuil, Camille, Annie Laquerrière, Matthieu Lecuyer, Carole Brasse-Lagnel, Sylvie Jégou, Soumeya Bekri, Pascale Marcorelles, Sophie Gil, Stéphane Marret y Bruno J. Gonzalez. "Alcoolisation fœtale". médecine/sciences 35, n.º 11 (noviembre de 2019): 859–65. http://dx.doi.org/10.1051/medsci/2019167.

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La consommation d’alcool au cours de la grossesse constitue une cause majeure de troubles du comportement et de handicap. Alors qu’il est possible pour un clinicien d’établir un diagnostic néonatal du syndrome d’alcoolisation fœtale, l’atteinte la plus sévère des troubles causés par l’alcoolisation fœtale (TCAF), une grande majorité des enfants échappe à un diagnostic précoce en raison de l’absence d’anomalies morphologiques évidentes. Plusieurs années de prise en charge sont alors perdues. Des avancées récentes ont permis d’établir l’existence d’un axe fonctionnel placenta-cerveau impliqué dans le contrôle de l’angiogenèse cérébrale, qui se trouve dérégulé chez les enfants exposés in utero à l’alcool. Une angiogenèse cérébrale normale étant un prérequis à l’établissement d’un neurodéveloppement correct, ces avancées ouvrent la voie à l’identification d’une nouvelle génération de biomarqueurs placentaires d’atteinte cérébrale pour le diagnostic précoce des enfants TCAF.
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Nath, Sujoy Kumar, Dipak Debnath, Kaushik Chatterjee, Riya Bhowmick, Hsiang-Kuang Chang y Sandip K. Chakrabarti. "Accretion Flow Properties of EXO 1846-031 during Its Multi-peaked Outburst after Long Quiescence". Astrophysical Journal 960, n.º 1 (18 de diciembre de 2023): 5. http://dx.doi.org/10.3847/1538-4357/ad0735.

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Abstract We study the recent outburst of the black hole candidate EXO 1846-031, which went into an outburst in 2019 after almost 34 yr in quiescence. We use archival data from the Swift/XRT, MAXI/GSC, NICER/XTI, and NuSTAR/FPM satellites/instruments to study the evolution of the spectral and temporal properties of the source during the outburst. The low-energy (2–10 keV) X-ray flux of the outburst shows multiple peaks, making it a multipeak outburst. Evolving type-C quasi-periodic oscillations are observed in the NICER data in the hard, hard-intermediate, and soft-intermediate states. We use the physical two-component advective flow (TCAF) model to analyze the combined spectra of multiple satellite instruments. According to the TCAF model, the accreting matter is divided into Keplerian and sub-Keplerian parts, and the variation in the observed spectra in different spectral states arises out of the variable contributions of these two types of accreting matter in the total accretion rate. Studying the evolution of the accretion rates and other properties of the accretion flow obtained from the spectral analysis, we show that the multiple peaks in the outburst flux arise out of the variable supply of accreting matter from the pile-up radius. We determine the probable mass of the black hole to be 10.4 − 0.2 + 0.1 M ⊙ from the spectral analysis with the TCAF model. We also estimate the viscous timescale of the source in this outburst to be ∼8 days from the peak difference of the Keplerian and sub-Keplerian mass-accretion rates.
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Tesis sobre el tema "Tcaf"

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Leroy, Anaïs. "Ιmplicatiοn du RΝΜDA endοthélial dans l'angiοgenèse rétinienne en cοnditiοns physiοlοgiques et dans un cοntexte d'alcοοlisatiοn fοetale". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR124.

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Le syndrome d’alcoolisation fœtale (SAF) est la principale cause de retard mental et représente la forme la plus sévère des troubles causés par l’alcoolisation fœtale (TCAF). Il se caractérise par divers troubles du neurodéveloppement, et son diagnostic repose sur un retard de croissance anté- et/ou postnatal, des anomalies du système nerveux central (SNC), et une dysmorphie crânio-faciale présente dès la naissance. Toutefois, la majorité des enfants exposés in utero à l’alcool ne présentent pas ces dysmorphies caractéristiques, bien qu’ils développent progressivement des troubles du neurodéveloppement. Cela entraîne des errances diagnostiques pour nombre d’enfants TCAF. Un diagnostic précoce permettrait une prise en charge rapide et adaptée, à un moment où la plasticité cérébrale est importante.Des travaux antérieurs de notre laboratoire ont montré qu’une exposition in utero à l’alcool entraîne des atteintes de l’angiogenèse et de la migration cellulaire corticale, tant chez l’humain que dans un modèle murin reproduisant un phénotype TCAF. Par ailleurs, la littérature met en évidence des atteintes oculaires, notamment une vascularisation rétinienne altérée chez les individus atteints de SAF. Étant donné que la rétine est une extension du SNC, nous avons émis l’hypothèse que les anomalies neurovasculaires cérébrales observées pourraient également être présentes au niveau de la rétine. Une première partie de mes travaux de thèse a consisté à caractériser les atteintes neurovasculaires de la rétine dans un modèle d’exposition prénatale à l’alcool (EPA). Les résultats ont mis en évidence un retard de développement du réseau vasculaire et une perturbation de l’organisation des cellules neuronales rétiniennes, notamment des cellules ganglionnaires et des interneurones immatures associés aux vaisseaux perforants.Les mécanismes moléculaires des effets de l’alcool sur le neurodéveloppement restent complexes et mal compris en raison des nombreuses cibles de l’éthanol. Parmi elles, le récepteur NMDA (RNMDA) est particulièrement affecté en présence d’alcool et joue un rôle dans la tolérance, la dépendance et le sevrage. Ce récepteur, exprimé par les cellules endothéliales néonatales, participe également aux processus angiogéniques. La deuxième partie de ma thèse a donc consisté à étudier l’implication du RNMDA endothélial dans le développement neurovasculaire de la rétine, en conditions physiologiques et après EPA. Un modèle murin invalidé pour le RNMDA au niveau endothélial a été utilisé. Les résultats montrent un retard dans le développement du réseau vasculaire rétinien et une altération du nombre des cellules neuronales dans la rétine des souris invalidées. L’association des cellules amacrines avec les vaisseaux perforants est également perturbée. En condition physiopathologique, l’invalidation du RNMDA endothélial atténue, en partie, les effets de l’EPA sur le développement de la rétine, soulignant l’implication de ce récepteur dans les atteintes neurovasculaires induites par l’alcool.Étant donné que l’œil constitue une fenêtre vers le cerveau, il représente un outil de diagnostic prometteur dans diverses pathologies. Des analyses d’imagerie rétinienne in vivo, via le fond d’œil, la tomographie par cohérence optique (OCT), et l’électrorétinogramme, ont été mises en place pour déterminer si les anomalies neurovasculaires induites par une EPA pouvaient être détectées précocement par ces approches. Les résultats préliminaires suggèrent l’existence d’atteintes du réseau vasculaire et de la couche des cellules ganglionnaires, détectables par l’analyse du fond d’œil et d’OCT chez des animaux exposés à l’alcool in utero. L’ensemble de ces travaux indique que l’analyse des atteintes neurovasculaires de la rétine pourrait, à l’avenir, soutenir le diagnostic précoce des enfants TCAF. Une transposition de ces approches chez l’Homme dans un contexte d’alcoolisation fœtale est désormais nécessaire
Fetal Alcohol Syndrome (FAS) is the leading cause of intellectual disability and represents the most severe form of Fetal Alcohol Spectrum Disorders (FASD). It is characterized by various neurodevelopmental impairments, and its diagnosis relies on pre- and/or postnatal growth retardation, central nervous system (CNS) anomalies, and craniofacial dysmorphia present at birth. However, most children exposed to alcohol in utero do not display these characteristic dysmorphias, though they progressively develop neurodevelopmental disorders. This results in diagnostic delays for many FASD-affected children. Early diagnosis would enable prompt and appropriate intervention, especially when brain plasticity is high.Previous work from our laboratory has shown that in utero exposure to alcohol impairs angiogenesis and cortical cell migration, both in humans and in a murine model reproducing an FASD phenotype. Additionally, the literature highlights ocular impairments, including altered retinal vascularization in individuals affected by FAS. Since the retina is an extension of the CNS, we hypothesized that the neurovascular anomalies observed in the brain might also be present in the retina. The first part of my doctoral work focused on characterizing neurovascular impairments in the retina in a model of prenatal alcohol exposure (PAE). The findings revealed delayed development of the vascular network and disrupted organization of retinal neuronal cells, particularly ganglion cells and immature interneurons associated with penetrating vessels.The molecular mechanisms of alcohol’s effects on neurodevelopment remain complex and poorly understood due to the numerous targets of ethanol. Among these, the NMDA receptor (NMDAR) is particularly affected by alcohol and plays a role in tolerance, dependence, and withdrawal. This receptor, expressed by neonatal endothelial cells, also participates in angiogenic processes. The second part of my thesis focused on studying the involvement of endothelial NMDAR in retinal neurovascular development under both physiological conditions and after PAE. A murine model with endothelial-specific NMDAR deletion was used. The results demonstrate a delay in the development of the retinal vascular network and an alteration in the number of neuronal cells in the retinas of the NMDAR-deficient mice. The association of amacrine cells with penetrating vessels was also disrupted. Under pathological conditions, endothelial NMDAR deletion partially attenuated the effects of PAE on retinal development, highlighting the involvement of this receptor in alcohol-induced neurovascular impairments.Since the eye provides a window into the brain, it represents a promising diagnostic tool for various pathologies. In vivo retinal imaging analyses, using fundus photography, optical coherence tomography (OCT), and electroretinography, were implemented to determine if neurovascular anomalies induced by PAE could be detected early by these methods. Preliminary results suggest that impairments in the vascular network and ganglion cell layer can be detected through fundus and OCT analysis in animals exposed to alcohol in utero. Collectively, this research indicates that retinal neurovascular impairment analysis could, in the future, support the early diagnosis of FASD-affected children. Transposing these approaches to humans in the context of fetal alcohol exposure is now necessary
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Sautreuil, Camille. "Etude du CD146 placentaire comme biomarqueur de troubles de l'angiogenèse cérébrale suite à une alcoolisation in utero. Alcoolisation foetale : le placenta au secours du diagnostic précoce des troubles du développement cérébral de l'enfant Impaired expression of the angiogenic placental factor CD146 by in utero alcohol exposure alters the fetal brain vasculature". Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR149.

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Le Syndrome d’Alcoolisation Foetale (SAF) est l’atteinte la plus sévère des Troubles Causés par l’Alcoolisation Foetale (TCAF). Il se traduit, chez l’enfant, par une triade de manifestations cliniques (dysmorphies craniofaciales, retard de croissance pré et postnatal, troubles neurologiques et comportementaux). Toutefois, en raison de l’absence d’anomalies morphologiques évidentes, la plupart des enfants TCAF échappent à un diagnostic précoce. Pour autant, ces enfants ne sont pas dépourvus d’atteintes cérébrales et les conséquences neurodéveloppementales et comportementales se révèleront progressivement avec l’âge. Le défi, pour les cliniciens, consiste donc à diagnostiquer au plus tôt ces enfants TCAF afin de mettre en place un accompagnement adapté à une période (0-5 ans) où le potentiel de récupération est important. A ce jour, même s’il existe des biomarqueurs d’exposition à l’alcool, ces derniers ne permettent pas de déterminer s’il y a eu une atteinte cérébrale. De récents travaux menés au Laboratoire ont mis en évidence l’existence d’un lien fonctionnel « Placenta-Cerveau » impliqué dans le contrôle de l’angiogenèse corticale du foetus. Ainsi, le PlGF a été identifié comme un premier biomarqueur placentaire d’atteinte cérébrale et une procédure de valorisation a été engagée. Mon projet de thèse a consisté à rechercher si un autre facteur pro-angiogénique placentaire associé au signalosome du PlGF/VEGF, le CD146, pouvait également constituer un acteur de la dysfonction Placenta-Cerveau suite à l’exposition in utero à l’alcool. De plus, une approche sans a priori par analyse transcriptomique inter-organes a également été initiée pour tenter d’élargir la signature « angiogénique » des effets délétères de l’alcool sur la communication entre ces deux organes. Concernant l’étude sur le CD146, les données obtenues sur des extraits de villosités de placenta humain montrent que le profil d’expression des ARNm codant le CD146 ne varie pas à différents stades gestationnels. En revanche, l’étude du profil protéique par la technique de Western blot indique une augmentation marquée de l’expression de la forme membranaire du CD146 avec le terme, et la forme soluble du CD146 est clairement détectée. Chez la Souris, les profils d’expression ARNm et protéique au niveau placentaire sont comparables à ceux caractérisés chez l’humain. L’immunohistochimie indique que l’expression du CD146 est endothéliale. De plus, les résultats obtenus par une approche ELISA indiquent que le sCD146 est détecté dans le sang céphalique foetal. Dans le cerveau, le CD146 est beaucoup moins exprimé que dans le placenta, et la forme membranaire est majoritaire. L’alcoolisation in utero perturbe les expressions placentaire et cérébrale de la forme soluble de CD146 en la diminuant fortement dans le placenta et en l’augmentant dans le cerveau foetal. De plus, certains éléments du signalosome du CD146 ont une expression qui est inversement altérée entre le placenta et le cerveau. Enfin, la répression placentaire du CD146 par l’électroporation de CRISPR-Cas9 entraîne une désorganisation du réseau microvasculaire cortical comparable à celle observée suite à une exposition in utero à l’alcool. En complément de l’étude ciblée sur le CD146, une étude sans a priori a été menée par analyse transcriptomique. Les résultats indiquent que l’alcoolisation in utero affecte peu, quantitativement, la signature transcriptomique « Placenta-Cerveau ». Toutefois, l’alcoolisation se traduit par l’émergence de populations géniques qui sont soit spécifiquement présentes dans le groupe « Contrôle » ou dans le groupe « Alcool ». Une analyse qualitative GO orientée « Angiogenèse » a permis d’identifier une liste de gènes dont le profil d’expression « Placenta-Cerveau » est significativement impactée par l’alcool. Une étape de validation de certains de ces gènes va être engagée
Fetal Alcohol Syndrome (FAS) refers to the most severe expression of Fetal Alcohol Spectrum Disorder (FASD). It associates several clinical defects such as craniofacial dysmorphism, growth retardation and neurological/behavioral disabilities. However, due to the absence of obvious dysmorphic features, most children with FASD are late or misdiagnosed. Nevertheless, these infants are not devoid of neurodevelopmental impairments and neurobehavioral troubles that will progressively appear with age. Consequently, the challenge for clinicians consists in the early diagnosis of FASD to avoid the loss of precious years of care. Even if several biomarkers of alcohol exposure have been characterized, there are currently no biomarkers of brain defects. Recent data from the Laboratory have shown a functional link “Placenta-Brain” involved in the control of the fetal cortical angiogenesis. Thus, PlGF has been identified as a first placental biomarker of brain impairments, and a valorization process has been initiated. My thesis project consisted to research if another placental proangiogenic factor associated to the VEGF/PlGF signalosome could also be an actor of the Placenta-Brain dysfunction induced by in utero alcohol exposure. Moreover, a non-oriented trans-organ transcriptomic approach has also been initiated trying to broaden the “angiogenic” signature of the alcohol-induced deleterious effects on the placenta-brain axis. About the CD146 study, data obtained on villous extracts from human placentas showed that the expression profile of mRNA didn’t changed between gestational weeks. However, Western blot analyses showed a marked increase of the expression of the membrane form (mCD146) with term and the soluble form sCD146 was clearly detected. In mouse, the mRNA and protein expression profiles in the placenta were very similar to those characterized in human. Immunohistochemistry indicated that the CD146 expression is at least endothelial. Moreover, results obtained by ELISA indicated that the sCD146 is detected in the fetal cephalic blood. In the mouse brain, the expression of CD146 was much less expressed than in the placenta and mCD146 is the main form. In utero alcohol exposure disrupted the expression of sCD146 decreasing in the placenta and increasing in the fetal brain. Additionally, several members of the CD146 signalosome were inversely impacted by alcohol between the placenta and the fetal brain. Finally, the placental repression of CD146 by in utero electroporation of CD146 CRISPR-Cas9 plasmids resulted in a disorganization of the microvascular cortical network, similar to the one observed after an in utero alcohol exposure. In addition to the first study focused on CD146, a non-oriented transcriptomic approach was undertaken to investigate the effects of alcohol on the placenta-brain interactions. Results indicated that in utero alcohol exposure have quantitatively a little impact on the “Placenta-Brain” transcriptomic signature. Nevertheless, alcohol exposure induced specific dysregulations of genes representative of the placenta/brain axis and a qualitative GO analysis using the “angiogenesis” filter allowed us to identify a list of genes significantly impaired. A validation step is now planned. To conclude, the targeted approach done on CD146 supports the existence of a functional placenta-fetal brain interaction and involved in the control of angiogenesis. The CD146 could constitute another placental biomarker of brain development defects induced by in utero alcohol exposure. Moreover, the transcriptomic approach has provided promising data regarding angiogenesis dysfunction and neurodevelopmental troubles and it would contribute to the characterization of a transcriptomic signature for the early diagnosis of FASD
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Kumar, Anuj. "Increasing TLB reach using TCAM cells". Thesis, Texas A&M University, 2004. http://hdl.handle.net/1969.1/1341.

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We propose dynamic aggregation of virtual tags in TLB to increase its coverage and improve the overall miss ratio during address translation. Dynamic aggregation exploits both the spatial and temporal locality inherent in most application programs. To support dynamic aggregation, we introduce the use of ternary-CAM (TCAM) cells at the second-level TLB. The modified TLB architecture results in an increase of TLB reach without additional CAM entries. We also adopt bulk prefetching concurrently with aggregation technique to enhance the benefits due to spatial locality. The performance of the proposed TLB architecture is evaluated using SPEC2000 benchmarks concentrating on those that show high data TLB miss ratios. Simulation results indicate a reduction in miss ratios between 59% and 99.99% for all the considered bench-marks except for one benchmark, which has a reduction of 10%. We show that the L2 TLB when enhanced using TCAM cells is an attractive solution to high miss ratios exhibited by applications.
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Surprise, Jason Mathew. "An energy efficient TCAM enhanced cache architecture". Texas A&M University, 2005. http://hdl.handle.net/1969.1/2314.

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Microprocessors are used in a variety of systems ranging from high-performance super computers running scientific applications to battery powered cell phones performing realtime tasks. Due to the large disparity between processor clock speed and main memory access time, most modern processors include several caches, which consume more than half of the total chip area and power budget. As the performance gap between processors and memory has increased, the trend has been to increase the size of the on-chip caches. However, increasing the cache size also increases its access time and energy consumptions. This growing power dissipation problem is making traditional cooling and packaging techniques less effective thus requiring cache designers to focus more on architectural level energy efficiency than performance alone. The goal of this thesis is to propose a new cache architecture and to evaluate its efficiency in terms of miss rate, system performance, energy consumption, and area overhead. The proposed architecture employs the use of a few Ternary-CAM (TCAM) cells in the tag array to enable dynamic compression of tag entries containing contiguous values. By dynamically compressing tag entries, the number of entries in the tag array can be reduced by 2N, where N is the number of tag bits that can be compressed. The architecture described in this thesis is applicable to any cache structure that uses Content Addressable Memory (CAM) cells to store tag bits. To evaluate the effectiveness of the TCAM Enhanced Cache Architecture for a wide scope of applications, two case studies were performed ?? the L2 Data-TLB (DTLB) of a high-performance processor and the L1 instruction and data caches of a low-power embedded processor. Results indicate that a L2 DTLB implementing 3-bit tag compression can achieve 93% of the performance of a conventional L2 DTLB of the same size while reducing the on-chip energy consumption by 74% and the total area by 50%. Similarly, an embedded processor cache implementing 2-bit tag compression achieves 99% of the performance of a conventional cache while reducing the on-chip energy consumption by 33% and the total area by 10%.
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Al-S'adi, Mahmoud. "TCAD based SiGe HBT advanced architecture exploration". Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14239/document.

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Dans le but d’améliorer les transistors bipolaires TBH SiGe, nous proposons d’étudier l’impact de la contrainte mécanique sur leurs performances. En effet, cette contrainte permet de libérer un degré de liberté supplémentaire pour améliorer les propriétés du transport grâce à un changement de la structure de bande d’énergie du semiconducteur. Ainsi, nous avons proposé de nouvelles architectures de composants basées sur l’ingénierie de la contrainte mécanique dans les semiconducteurs. Deux approches ont été utilisées dans cette étude pour générer la tension mécanique adéquate à l'intérieur du dispositif. La première approche consiste à appliquer une contrainte mécanique sur la base du transistor en utilisant une couche de SiGe extrinsèque. La seconde approche vise à appliquer une contrainte dans la région du collecteur en utilisant une couche contrainte. Les résultats obtenus montrent que cette méthode peut être une approche prometteuse pour améliorer les performances des TBH
The Impact of strain engineering technology applied on Si BJT/SiGe HBT devices on the electrical properties and frequency response has been investigated. Strain technology can be used as an additional degree of freedom to enhance the carriers transport properties due to band structure changes and mobility enhancement. New concepts and novel device architectures that are based on strain engineering technology have been explored using TCAD modeling. Two approaches have been used in this study to generate the proper mechanical strain inside the device. The first approach was through introducing strain at the device’s base region using SiGe extrinsic stress layer. The second approach was through introducing strain at the device’s collector region using strain layers. The obtained results obviously show that strain engineering technology principle applied to BJT/HBT device can be a promising approach for further devices performance improvements
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Thai, Emily (Emily Sue). "TCAQ-based polymer for electrochemically mediated separations". Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111357.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Materials Science and Engineering, 2017.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 35-36).
Redox-mediated separation systems offer the potential to efficiently desalinate water and to purify contaminated waste streams, among other health and environmental applications. A TCAQ-based polymer, unique for its two-electron redox reaction, was synthesized for use in redox-mediated separation systems, and its performance was quantified in low-concentration aqueous salt solutions. The polyvinyl ferrocene (PVF)//PTCAQ system displayed an ion adsorption capacity much higher than previously reported literature values for capacitive or redox deionization systems.
by Emily Thai.
S.B.
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Gappisch, Steffen. "TCAD-based development of a flash-EPROM technology /". [S.l.] : [s.n.], 1996. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11581.

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Tang, Jun. "Causal models for analysis of TCAS-induced collisions". Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/309134.

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Una sèrie de col·lisions aèries que van succeir durant un període d’uns 30 anys (1956-1986) van ser un dels principals motius pels quals l’Administració Federal d’Aviació (FAA) va prendre la decisió de desenvolupar i implementar un sistema de prevenció de col·lisions eficaç que actués com a últim recurs, quan es produís una fallada del servei de separació d’aeronaus per part del controlador de trànsit aeri (ATC). El Sistema d’Alerta de Trànsit i Anticol·lisió (TCAS) va ser desenvolupat per a aquest objectiu a partir d’una anàlisi completa de dades de vol. Com a resultat, la influència de TCAS en la seguretat del vol ha estat eficaç, beneficiosa i significativa en la reducció de la probabilitat de col·lisions. Els projectes Single European Sky ATM Research (SESAR) i Next Generation Air Transportation System (NextGen) pretenen millorar l’eficiència en la gestió del tràfic aeri (ATM) al mateix temps que es pretén reduir l’actual capacitat latent en el costat aire mitjançant la incorporació de noves tecnologies i procediments. En conseqüència, serà necessari investigar l’impacte en seguretat en augmentar la capacitat de l’espai aeri mitjançant una anàlisi exhaustiva i una avaluació efectiva del vol. En aquesta tesi, es proposen diversos models causals de colisions entre aeronaus per millorar el rendiment del TCAS tenint en compte el potencial efecte sobre el trànsit colindant, considerant escenaris futurs amb un nombre elevat de trajectòries. Els diferents models han estat especificats com a sistemes a esdeveniments discrets mitjançant el formalisme de Xarxes de Petri Acolorides. Mitjançant l’anàlisi de l’espai d’estat d’un volum d’espai aeri amb diverses aeronaus, els models desenvolupats avaluen els efectes dels diferents RAs generats pel TCAS sobre el tràfic col·lindant. Els models han estat validats utilitzant InCAS i ofereixen una perspectiva global de les dinàmiques que es generen, i una millor comprensió de les potencials col·lisions induïdes per a una millor valoració del risc de col·lisió. Com a resultat, els escenaris amb tràfic col·lindant que podrien iniciar col·lisions induïdes han estat identificats i caracteritzats. L’anàlisi quantitativa del factor de risc de col·lisions induïdes per TCAS ha estat realitzat per avaluar l’impacte de la demora del pilot per respondre als avisos TCAS durant el vol en escenaris d’alta densitat. Mitjançant l’ús de models estocàstics per representar la resposta del pilot s’han analitzat els diferents estats assolibles amb l’objectiu de generar resolucions cooperatives. En conseqüència, el rendiment de TCAS es podria millorar de forma innovadora sense necessitat d’introduir canvis rellevants en la lògica. Els models causals de col·lisions proposats poden ser utilitzats com a eines auxiliars en l’anàlisi d’escenaris de tràfic dens, i augmentar la capacitat de l’espai aeri, gestionant de manera eficient i segura un major nombre de vols. El present treball contribueix a continuar les investigacions en l’anàlisi de la seguretat dels conceptes ATM actuals i avançats, incloent les futures extensions de TCAS.
Una serie de colisiones en el aire que ocurrieron durante un período de unos 30 años (1956-1986) fueron uno de los principales motivos por los que la Administración Federal de Aviación (FAA) tomó la decisión de desarrollar e implementar un sistema de prevención de colisiones eficaz que actuara como último recurso, cuando se produjese un fallo del servicio de separación de aeronaves por parte del controlador de tránsito aéreo (ATC). El Sistema de Alerta de Tráfico y Anticolisión (TCAS) fue desarrollado para este objetivo a partir de un análisis completo de datos de vuelo. Como resultado La influencia de TCAS en la seguridad del vuelo ha sido eficaz, beneficiosa y significativa en la reducción de la probabilidad de colisiones. Los proyectos Single European Sky ATM Research (SESAR) y Next Generation Air Transportation System (NextGen) pretenden mejorar la eficiencia en la gestión del tráfico aéreo (ATM) al mismo tiempo que se pretende reducir la actual capacidad latente en el lado aire mediante la incorporación de nuevas tecnologías y procedimientos,. En consecuencia, va a ser necesario investigar el impacto en seguridad al aumentar la capacidad del espacio aéreo mediante un análisis exhaustivo y una evaluación efectiva del vuelo. En esta tesis, se proponen varios modelos causales de encuentro entre aeronaves para mejorar el rendimiento del TCAS teniendo en cuenta el potencial efecto sobre el tráfico colindante, considerando escenarios futuros con un número elevado de trayectorias. Los diferentes modelos han sido especificados como sistemas a eventos discretos mediante el formalismo de Redes de Petri Coloreadas. Mediante el análisis del espacio de estado de un volumen de espacio aéreo con varias aeronaves, los modelos desarrollados evalúan los efectos de los distintos RAs generados por TCAS sobre el tráfico colindante. Los modelos han sido validados utilizando InCAS y ofrecen una perspectiva global de las dinámicas que se generan, y una mejor comprensión de las potenciales colisiones inducidas para una mejor valoración del riesgo de colisión. Como resultado, los escenarios con tráfico colindante que podrían iniciar colisiones inducidas han sido identificados y caracterizados. El análisis cuantitativo del factor de riesgo de colisiones inducidas por TCAS ha sido realizado para evaluar el impacto de la demora del piloto para responder a los avisos TCAS durante el vuelo en escenarios de alta densidad. Mediante el uso de modelos estocásticos para representar la respuesta del piloto se han analizado los diferentes estados alcanzables con el objetivo de generar resoluciones cooperativas. En consecuencia, el rendimiento de TCAS se podría mejorar de forma innovadora sin necesidad de introducir cambios relevantes en la lógica. Los modelos de encuentros causales propuestos pueden ser utilizados como herramientas auxiliares en el análisis de escenarios de tráfico denso, y aumentar la capacidad del espacio aéreo, gestionando de manera eficiente y segura un mayor número de vuelos. El presente trabajo contribuye a continuar las investigaciones en el análisis de la seguridad de los conceptos ATM actuales y avanzados, incluyendo las futuras extensiones de TCAS.
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Saad, Yves. "TCAD-based three-dimensional modeling of nonvolatile memories /". Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17435.

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Ewert, Tony. "Advanced TCAD Simulations and Characterization of Semiconductor Devices". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6883.

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Libros sobre el tema "Tcaf"

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Workers, Canadian Auto. CAW TCA Canada. Toronto: CAW TCA Canada, 2000.

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Wu, Yung-Chun y Yi-Ruei Jhan. 3D TCAD Simulation for CMOS Nanoeletronic Devices. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-3066-6.

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Saad, Yves. TCAD-based three-dimensional modeling of nonvolatile memories. Konstanz: Hartung-Gorre, 2010.

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K, Maiti C. y Institution of Engineering and Technology, eds. TCAD for Si, SiGe and GaAs integrated circuits. London: Institution of Engineering and Technology, 2007.

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Begault, Durand R. 3-D audio versus head down TCAS displays. Moffett Field, Calif: National Aeronautics and Space Administration, Ames Research Center, 1994.

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T, Pittman Marc y Ames Research Center, eds. 3-D audio versus head down TCAS displays. Moffett Field, Calif: National Aeronautics and Space Administration, Ames Research Center, 1994.

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T, Pittman Marc y Ames Research Center, eds. 3-D audio versus head down TCAS displays. Moffett Field, Calif: National Aeronautics and Space Administration, Ames Research Center, 1994.

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Gappisch, Steffen. TCAD-based development of a flash-EPROM technology. Konstanz: Hartung-Gorre, 1996.

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Brukwicki, Jarosław. Wybrane zagadnienia obróbki skrawaniem z zastosowaniem metody TCAC. Poznań: Wydawn. Poznańskiego Tow. Przyjaciół Nauk, 1994.

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Li, Simon y Yue Fu. 3D TCAD Simulation for Semiconductor Processes, Devices and Optoelectronics. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-0481-1.

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Capítulos de libros sobre el tema "Tcaf"

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Ghosh, Arindam. "A Dynamic Photon Index Probes into TCAF". En Astrophysics and Space Science Proceedings, 311–27. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-94607-8_24.

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Turiault, Marc, Caroline Cohen, Guy Griebel, David E. Nichols, Britta Hahn, Gary Remington, Ronald F. Mucha et al. "TCAs". En Encyclopedia of Psychopharmacology, 1304. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4585.

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Gooch, Jan W. "TCEF". En Encyclopedic Dictionary of Polymers, 731. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_11581.

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Biala, Jacek. "TCAP-Anwender". En Mobilfunk und Intelligente Netze, 239–48. Wiesbaden: Vieweg+Teubner Verlag, 1996. http://dx.doi.org/10.1007/978-3-322-87270-8_10.

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Meiners, Chad R., Alex X. Liu y Eric Torng. "TCAM Razor". En Hardware Based Packet Classification for High Speed Internet Routers, 31–39. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-6700-8_4.

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Biala, Jacek. "TCAP-Anwender". En Mobilfunk und Intelligente Netze, 239–48. Wiesbaden: Vieweg+Teubner Verlag, 1994. http://dx.doi.org/10.1007/978-3-322-83660-1_10.

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Campbell, Daniel, Corey Ray-Subramanian, Winifred Schultz-Krohn, Kristen M. Powers, Renee Watling, Christoph U. Correll, Stephanie Bendiske et al. "Tricyclic Antidepressants (TCAs)". En Encyclopedia of Autism Spectrum Disorders, 3186. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_101480.

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Kotani, Norihiko. "TCAD in Selete". En Simulation of Semiconductor Processes and Devices 1998, 3–7. Vienna: Springer Vienna, 1998. http://dx.doi.org/10.1007/978-3-7091-6827-1_2.

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Ijjada, Sreenivasa Rao, Chaithanya Mannepalli y Md Hameed Pasha. "FinFET Modelling Using TCAD". En Proceedings of 2nd International Conference on Micro-Electronics, Electromagnetics and Telecommunications, 201–10. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4280-5_21.

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Li, Simon y Yue Fu. "Semiconductor Industry and TCAD". En 3D TCAD Simulation for Semiconductor Processes, Devices and Optoelectronics, 1–17. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0481-1_1.

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Actas de conferencias sobre el tema "Tcaf"

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Mondal, S., S. K. Chakrabarti y P. Nandi. "Accretion around low mass and supermassive black holes with TCAF". En Proceedings of the MG15 Meeting on General Relativity. WORLD SCIENTIFIC, 2022. http://dx.doi.org/10.1142/9789811258251_0018.

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Debnath, Dipak, Sandip K. Chakrabarti, Santanu Mondal, Arghajit Jana, Debjit Chatterjee, Aslam Ali Molla, Kaushik Chatterjee y Riya Bhowmick. "Understanding accretion flow properties of black hole candidates after implementation of the TCAF solution in XSPEC". En Proceedings of the MG15 Meeting on General Relativity. WORLD SCIENTIFIC, 2022. http://dx.doi.org/10.1142/9789811258251_0015.

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Debnath, Dipak, Sandip K. Chakrabarti, Santanu Mondal, Arghajit Jana, Aslam Ali Molla y Debjit Chatterjee. "Possible ASTROSAT observation of transient black hole candidates to study spectral and timing properties with TCAF solution". En Proceedings of the MG14 Meeting on General Relativity. WORLD SCIENTIFIC, 2017. http://dx.doi.org/10.1142/9789813226609_0419.

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Debnath, Dipak, Sandip K. Chakrabarti, Santanu Mondal, Arghajit Jana, Aslam Ali Molla y Debjit Chatterjee. "Accretion flow dynamics of a few transient black hole candidates from their spectral evolution study using TCAF solution". En Proceedings of the MG14 Meeting on General Relativity. WORLD SCIENTIFIC, 2017. http://dx.doi.org/10.1142/9789813226609_0054.

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Rivera, Jordan, Jonathan B. Hopkins y Charles Kim. "Synthesizing Soft Parallel Robots Comprised of Active Constraints". En ASME 2014 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/detc2014-34551.

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In this paper, we introduce a new type of spatial parallel robot that is comprised of soft inflatable constraints called Tri-Chamber Actuators (TCAs). We extend the principles of the Freedom and Constraint Topologies (FACT) synthesis approach to enable the synthesis and analysis of this new type of soft robot. The concepts of passive and active freedom spaces are introduced and applied to the design of general parallel systems that consist of active constraints (i.e., constraint that can be actuated to impart various loads onto the system’s stage) that both drive desired motions and guide the system’s desired degrees of freedom (DOFs). We provide the fabrication details of the TCA constraints introduced in this paper and experimentally validate their FACT-predicted kinematics. Examples are provided as case studies.
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"2012 TCF Information Technology Professional Conference - Table of contents". En 2012 IEEE TCF Information Technology Professional Conference (TCF Pro IT). IEEE, 2012. http://dx.doi.org/10.1109/tcfproit.2012.6221129.

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Hsu, Donald K. "Learning a new programming language? Why not C# .NET programming?" En 2012 IEEE TCF Information Technology Professional Conference (TCF Pro IT). IEEE, 2012. http://dx.doi.org/10.1109/tcfproit.2012.6221130.

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Qaisar, Eeraj Jan. "Introduction to cloud computing for developers: Key concepts, the players and their offerings". En 2012 IEEE TCF Information Technology Professional Conference (TCF Pro IT). IEEE, 2012. http://dx.doi.org/10.1109/tcfproit.2012.6221131.

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Deiner, Howard. "Take two beads and call me in the morning — Managing software development projects better". En 2012 IEEE TCF Information Technology Professional Conference (TCF Pro IT). IEEE, 2012. http://dx.doi.org/10.1109/tcfproit.2012.6221132.

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"Take two beads and call me in the morning: Managing software development projects better". En 2012 IEEE TCF Information Technology Professional Conference (TCF Pro IT). IEEE, 2012. http://dx.doi.org/10.1109/tcfproit.2012.6221133.

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Informes sobre el tema "Tcaf"

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Li, Xuan, Junjie Wang, Jing Mao y Yunnan Li. Therapeutic effects of traditional Chinese medicine fumigating plus Yang-He decoction for patients with ankylosing spondylitis: A systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2023. http://dx.doi.org/10.37766/inplasy2023.4.0074.

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Review question / Objective: To assess the therapeutic effects of combined TCMF with YHD for AS patients. Condition being studied: Traditional Chinese medicine fumigating (TCMF) and Yang-He decoction (YHD) are widely used for ankylosing spondylitis (AS), whether combined used TCMF and YHD provides superior therapeutic effects for AS remained unclear. Eligibility criteria: (1) Patients: adult patients diagnosed with AS; (2) Treatments: TCMF plus YHD, TCMF, YHD, and WM; (3) Outcomes: the primary endpoint was effective rate, and the secondary endpoints including Visual Analogue Scale (VAS) score, Schober test (ST), thoracic expansion (TE), finger-floor distance (FFD), pillow-wall distance (PWD), spinal column activity (SCA), morning stiffness time (MST), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP); and (4) Study design: the study had to have RCT design.
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Natera, José Miguel, Nadia Albis, Diana Suárez, Rodrigo Magaldi y Florencia Fiorentin. Enabling Factors for the Accumulation of Technological Capabilities in Innovative Firms: A Micro-Macro Approach in Latin America. Inter-American Development Bank, julio de 2024. http://dx.doi.org/10.18235/0013045.

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Enhancing the technological capability accumulation process (TCAP) in firms is essential for Latin America's economic development. Yet, the dynamics between firms' characteristics and contextual factors that can help improve TCAP remain underexplored in the region. This study assesses the effects on TCAP of firm-level factors and national innovation systems (NISs)the network of institutions, policies, and relationships governing innovation within a country. Using data from the harmonized Latin American Innovation Surveys Database (LAIS) and a dataset to measure capabilities at the country level, we undertake a multilevel analysis for 20062016 to estimate the effects of NISs and firms structural characteristics on TCAP. Our results reveal that firm size, R&D capabilities, qualified personnel, and macro factors like national R&D investment and scientific output significantly drive TCAP. Conversely, factors such as corruption perception emerge as significant obstacles. These findings underline the complex interplay between innovation policies and firm capabilities, offering nuanced insights for policymakers to foster innovation in Latin America.
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Yoshimura, A. S. Thermodynamic Cycle Analysis Program (TCAP). Office of Scientific and Technical Information (OSTI), enero de 1997. http://dx.doi.org/10.2172/481552.

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Klein, J. E. Conceptual Design for Consolidation TCAP. Office of Scientific and Technical Information (OSTI), febrero de 1999. http://dx.doi.org/10.2172/4820.

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PIERCE, ROBERTA. TCAP Aluminium Dissolution Flowsheet Basis. Office of Scientific and Technical Information (OSTI), marzo de 2004. http://dx.doi.org/10.2172/830004.

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THOMPSON, ANTHONY. SR19007 - FUTURE TCAP IMPLEMENTATION ISSUES. Office of Scientific and Technical Information (OSTI), septiembre de 2020. http://dx.doi.org/10.2172/1669102.

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Steimke, J. L. Transient Heat Transfer in TCAP Coils. Office of Scientific and Technical Information (OSTI), marzo de 1999. http://dx.doi.org/10.2172/4977.

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Berg, Larry K. Two-Column Aerosol Project (TCAP) Field Campaign Report. Office of Scientific and Technical Information (OSTI), mayo de 2016. http://dx.doi.org/10.2172/1254831.

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Berkowitz, CM, LK Berg, DJ Cziczo, CJ Flynn, EI Kassianov, JD Fast, PJ Rasch et al. The Two-Column Aerosol Project (TCAP) Science Plan. Office of Scientific and Technical Information (OSTI), julio de 2011. http://dx.doi.org/10.2172/1020266.

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Ferrero-Regis, Tiziana, Zoe Mellick y Justine Coneybeer. Stitching a future: Ethical labour and growth in the Queensland fashion and clothing industry. Queensland University of Technology, 2024. https://doi.org/10.5204/rep.eprints.254521.

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Executive summary South-East Queensland (SEQ) is Australia’s third-largest regional hub for textile, clothing, and footwear (TCF) manufacturing in terms of economic output and workforce. As Australia pursues policies to reshore manufacturing, creating higher-quality jobs in areas such as sorting, repair, resale, remanufacture to meet environmental targets and growing consumer demand for sustainably and ethically produced goods, the importance of ethical accreditation frameworks has become more pronounced. The aim of this study is to explore stakeholder perceptions of the benefits and barriers of ethical accreditation for TCF businesses in SEQ. It provides recommendations that support the region as a leader in ethical TCF manufacturing while supporting sustainability goals and worker protection. This report draws on research conducted in 2024, which included in-depth interviews with both ECA-accredited and non-accredited manufacturers, as well as a survey targeting stakeholders in the SEQ TCF industry. Data collection was centred on three key objectives: to understand businesses knowledge about ethical accreditation; to understand the role that accreditation plays for the growth of the industry; and to evaluate the opportunities and barriers surrounding ethical accreditation in SEQ. The findings highlight a complex landscape in which TCF businesses in Queensland are grappling with challenges related to legal compliance, accreditation and local manufacturing growth. While there is an awareness of the benefits of ethical accreditation, barriers such as knowledge gaps, the costs and time involved in the accreditation process, and resistance to external audits remain prevalent. Government policies that favour accredited businesses suggests that targeted incentives and support mechanisms are key to overcoming these barriers. Additionally, the skills gap in local manufacturing calls for a more coordinated and long-term strategy to ensure the growth and sustainability of the sector both in Queensland and Australia. Addressing these issues will be crucial in fostering an ethical and competitive TCF industry in the state.
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