Tesis sobre el tema "T cells responses"
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Crawford, A. "How B cells influence T cell responses". Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645118.
Texto completoCrawford, Alison. "Role of B cells in influencing T cell responses". Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13483.
Texto completoSmith, Trevor Robert Frank. "Modulation of CD4+ T cell responses by CD4+CD25+ regulatory T cells and modified T cell epitopes". Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11317.
Texto completoPreciado-Llanes, Lorena. "Inhibition of T-cell responses by microbes and immune cells". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4717/.
Texto completoBarroso, Herrera Osquel Miguel. "Manipulation of antigen-specific T cell responses by modified dendritic cells". Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405941.
Texto completoLi, Xiaoying. "T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva". Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19552.
Texto completoWangteeraprasert, Apirath. "CD8+ T-cells responses in Dengue virus infection". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39398.
Texto completoDeng, Jun y 鄧軍. "Leptin modulates T cells responses in autoimmune arthritis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208601.
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Pathology
Doctoral
Doctor of Philosophy
Sutherland, Andrew Peter Robert St Vincents Clinical School UNSW. "BAFF regulation of peripheral T cell responses". Awarded by:University of New South Wales. St Vincents Clinical School, 2005. http://handle.unsw.edu.au/1959.4/22788.
Texto completoEasterfield, Alistair John. "Foetal modulation of maternal T lymphocyte responses". Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325057.
Texto completoRitchie, Adam John Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Modulation of T cell responses by N-(3-oxododecanoyl)-L-homoserine lactone". Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/22005.
Texto completoMathieson, Peter William. "Role of T lymphocytes in autoimmune responses". Thesis, University of Cambridge, 1992. https://www.repository.cam.ac.uk/handle/1810/251527.
Texto completoWikstrom, Matthew E. "The regulation of peripheral T cell responses in TCR transgenic mice". Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/27641.
Texto completoMacArthur, Georgina. "Characterisation of CD4+ T cell responses towards Epstein-Barr virus-infected B cells". Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420895.
Texto completoTso, Hoi-wan. "Effects of phagocytosis of apoptotic cells by mesenchymal stem cells on osteogenesis and T cells responses /". View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39585475.
Texto completo曹凱韻 y Hoi-wan Tso. "Effects of phagocytosis of apoptotic cells by mesenchymal stem cells on osteogenesis and T cells responses". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39707520.
Texto completoAhem, David John. "Characterisation of CD4+CD25+ T cells regulatory responses to allergens". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499049.
Texto completoDianda, Lee. "Immune responses in mice deficient in #alpha##beta# T cells". Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244769.
Texto completoDe, Campos Pereira Lemos Sara Sofia. "CD8 T cell differentiation during immune responses". Phd thesis, Université René Descartes - Paris V, 2014. http://tel.archives-ouvertes.fr/tel-01059806.
Texto completoSaunders, Margaret. "Analysis of immune responses to transformed cells in vitro". Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481435.
Texto completoGurung, Prajwal. "Regulation of immune responses by apoptotic cells". Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/974.
Texto completoCobb, Dustin. "T-bet-dependent regulation of T cell responses during Trypanosoma cruzi infection". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/372.
Texto completoTomkins, Paul Thomas. "Interferon modulation of T-cell responses to Semliki Forest virus infected murine brain cells". Thesis, University of Warwick, 1989. http://wrap.warwick.ac.uk/101165/.
Texto completoStelekati, Erietta [Verfasser]. "The role of mast cells in CD8+ T cell-mediated immune responses / Erietta Stelekati". Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1019951877/34.
Texto completoLidehäll, Anna Karin. "Cellular Immune Responses to Cytomegalovirus". Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8578.
Texto completoCytomegalovirus (CMV) is a widespread infection affecting 50-90% of the human population. A typical silent primary infection is followed by life-long persistence in the host under control by virus-specific CD8 (“killer”) and CD4 (“helper”) T cells. Although harmless in most people, CMV may cause disease and sequelae in patients with deficient cellular immunity, such as AIDS patients, recipients of organ transplants and children who have acquired the virus before birth. In this thesis we have characterized the cellular immunity to CMV in immunocompetent subjects, in patients receiving transplants and in infants.
In healthy individuals with latent CMV, the frequencies of CMV-specific CD8 T cells varied considerably between the donors. Within the same individual, the changes over time were usually small. In patients with primary, symptomatic CMV infection, the frequencies of CMV-specific CD8 T cells peaked within the first month after the appearance of symptoms. The frequencies then declined to levels similar to those in latently infected CMV carriers. The CD4 T-cell function followed the same pattern, but with lower peak values.
Immunosuppressed renal transplant patients with latent CMV had CMV-specific CD4 cell function similar to healthy controls. The frequencies of CMV-specific CD8 T cells were also comparable, but their function was impaired. When renal transplant recipients were investigated longitudinally, we found that their CMV-specific T cells decreased rapidly after transplantation. Whereas the frequencies and function of CD8 T cells rebounded within 3 months, CD4 T-cell recovery was impaired during the entire first year after transplantation.
Finally, the frequencies and function of CMV-specific T-cells were investigated in children with congenital and postnatal CMV. CMV-specific CD8 T cells could be detected in even the youngest children, suggesting that these cells can develop early in life. In contrast, CMV specific CD4 T cells were low or absent in the youngest children but increased slowly with age.
Omodho, Becky. "Early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells". Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13516.
Texto completoMarshall, Heather D. "Sensitization of CD8 T Cells During Acute Viral Infections Impacts Bystander and Latecomer CD8 T Cell Responses : A Dissertation". eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/440.
Texto completoSanchez-Silva, Martin Antonio. "Analysis of local T cell responses in experimental visceral leishmaniasis". Thesis, London School of Hygiene and Tropical Medicine (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326241.
Texto completoWorthington, Joy. "T cell responses in the pathogenesis of cholestatic liver disease". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.564278.
Texto completoAhern, David John. "Characterisation of CD4+CD25+ T cells in regulatory responses to allergens". Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/11507.
Texto completoMartin, Matthew David. "Naive and memory CD8 T cell responses after antigen stimulation in vivo". Thesis, University of Iowa, 2011. https://ir.uiowa.edu/etd/1246.
Texto completoGoddard, Ruth Victoria. "Generation of in vitro B-cell chronic lymphocytic leukaemia-specific T cell responses using dendritic cells". Thesis, University of Plymouth, 2002. http://hdl.handle.net/10026.1/2695.
Texto completoLemos, Sara Sofia de Campos Pereira. "CD8 T cell differentiation during immune responses". Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T009/document.
Texto completoCD8 T cells are essential for the elimination of intracellular pathogens and tumor cells. Understanding how naïve CD8 T cells differentiate into effector cells capable of eliminating pathogens and to generate adequate memory cells during immune responses is fundamental for optimal T cell vaccine design. In this PhD thesis work we addressed two central questions: 1) What are the mechanisms by which early effector T cells could act as pro-inflammatory effectors? And what is their role in the immune response? 2) How heterogeneous are CD8 responses? Could different pathogens modulate CD8 T cell differentiation programs and be responsible for CD8 cell-to-cell heterogeneity? Could they also generate memory cells with different protection capacities? To address these questions related to the diversity of CD8 T cell differentiation during immune responses, we used the single cell RT-PCR technique to detect ex vivo expression of mRNA in each individual cell, and Brefeldin A injected mice to detect ex vivo intracellular proteins. As experimental system to evaluate in vivo cell activation we used T cell receptor transgenic (TCR-Tg) CD8 T cells. Since the use of TCR-Tg cells to study immune responses has been subjected to criticism (due to high frequency of naïve-precursor transfers), in a first Ms. we compared the behavior of TCR-Tg and endogenous (non-transgenic and present at low frequency) cells in the same mouse. We found fully overlapping behavior between these two cell populations, which reinforced the advantage of using TCR-Tg cells to study CD8 immune responses. In addition, we concluded that the frequency of naïve-precursors do not induce diversity on CD8 T cell differentiation patterns. In a second Ms. we evaluated the impact of different pathogens in the diversity of CD8 T cell properties during two different immune responses: OT1 TCR-Tg cells (specific for OVA antigen) in the response to LM-OVA (Listeria Monocytogenes expressing OVA) infection; and P14 TCR-Tg cells (specific for GP33 epitope) in the response to Lymphocytic choriomeningitis vírus (LCMV) infection. We found that OT1 and P14 cells had different properties. As this difference could also be attributed to the different TCR avidity between OT1 and P14 cells, we then compared the behavior of P14 and OT-1 cells in the same mouse, co-injected with LM-OVA and LM-GP33. Since no differences were then detected, these results demonstrated that priming with different pathogens generates CD8 T cells with different characteristics that are not determined by TCR usage, but rather by the infection context. In addition, when looking for the protection capacity of endogenous CD8 memory cells generated in bacterial or viral context, we found that memory cells generated after LCMV priming were more efficient in responding to a second challenge, than memory cells generated after LM-GP33 priming. We also found that this better protection is associated with a T cell effector memory (TEM) phenotype associated with the LCMV infection, in contrast with a T cell central memory (TCM) phenotype generated after LM-OVA infection. These results demonstrate that different pathogens are responsible for diversity of CD8 T cell differentiation patterns and that even when distinct pathogens are efficiently eliminated during the primary immune response the quality of the memory generated may differ. In a third Ms. we studied the mechanisms by which effector CD8 T cells attracted other cell types in the early days of an immune response. We used two experimental systems: the response of OT1 TCR-Tg cells to LM-OVA infection; and the response of anti-HY TCR-Tg cells to male cells (“sterile”-non infectious context). In both cases we found that immediately after activation, CD8 T cells expressed high levels of pro-inflammatory cytokines and chemokines (such as TNFα, XCL1, CCL3 and CCL4). (...)
Omilusik, Kyla Dione. "The requirement for competent antigen presenting dendritic cells and poised T cells for immune responses". Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36789.
Texto completoSampangi, Sandeep. "Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses". Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82033/1/Sandeep_Sampangi_Thesis.pdf.
Texto completoSivaganesh, Sivasuriya. "Recipient DCs presenting intact and processed MHC alloantigen mediate CD8⁸ T-cell responses". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609327.
Texto completoNarendran, Partheepan. "Immune responses to proinsulin in type 1 diabetes mellitus". Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325704.
Texto completoSon, Aoi. "Dendritic cells derived from TBP-2 deficient mice are defective to induce T cell responses". Kyoto University, 2008. http://hdl.handle.net/2433/124222.
Texto completoHaileselassie, Yeneneh. "Lactobacilli- and Staphylococcus aureus mediated modulation of immune responses in vitro". Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-127399.
Texto completoAt the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 2: Submitted.
Sivakuru, Thamayanthi. "Lung mucosal Th2 responses are regulated by CD4+CD25+ suppressor T cells". Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404470.
Texto completoProvine, Nicholas Mcdermott. "CD4 T Cells Regulate Adenovirus Vector-Elicited Cellular and Humoral Immune Responses". Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718733.
Texto completoMedical Sciences
Malavige, Gathsaurie Neelika. "Investigation of varicella zoster virus glycoprotein-specific T cell responses". Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:52445512-fce7-4083-a4b1-f8adf3d3b315.
Texto completoLu, Yu-Jung. "The Role of CD4 T Cell Help in Effective CD8 T Cell Responses during Mycobacterium Tuberculosis Infection". eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1139.
Texto completoHall, Håkan. "T cell responses and NK cell function in experimental autoimmune diabetes /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-152-0/.
Texto completoBenlahrech, Adel Ridha. "Activation of natural killer and cytotoxic T cell responses by dendritic cells in HIV-1 infection". Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440445.
Texto completoWasser, Beatrice [Verfasser]. "Myeloid cells in the CNS counteract neuroinflammation via cellular responses to T cell infiltration / Beatrice Wasser". Mainz : Universitätsbibliothek Mainz, 2020. http://d-nb.info/1208881582/34.
Texto completoSircar, Piya. "Clonal Analysis of Mucosal SIV-Specific CD8+ T Cell Responses". Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10035.
Texto completoFankhauser, Sarah Carmela. "Characterization of impaired CD8+ T cell responses to Chlamydia trachomatis". Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11158.
Texto completoRaymond, Meera V. "Early growth response gene-2 controls inflammatory responses of CD4+ T cells by negatively regulating Th17 differentiation". Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8953.
Texto completoArima, Hiroshi. "B cells with aberrant activation of Notch1 signaling promote Treg and Th2 cell-dominant T cell responses via IL-33". Kyoto University, 2019. http://hdl.handle.net/2433/236612.
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