Tesis sobre el tema "T cell"
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Sarris, Milka. "Dynamics of helper T cell and regulatory T cell interactions with dendritic cells". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611896.
Texto completoCarson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.
Texto completoLloyd, Angharad. "Gene editing in T-cells and T-cell targets". Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/98512/.
Texto completoStefkova, Martina. "Regulatory T cells control the CD4 T cell repertoire". Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/233151/3/Table.pdf.
Texto completoRecent studies conducted in mice and humans have suggested a role for the TCR repertoire diversity in immune protection against pathogens displaying high antigenic variability. To study the CD4 T cell repertoire, we used a mouse model in which T cells transgenically express the TCRβ chain of a TCR specific to a MHCII-restricted peptide, env122-141. Upon immunization with peptide-pulsed dendritic cells, antigen-specific Vα2+ CD4+ T cells rapidly expand and display a restricted TCRα repertoire. In particular, analysis of receptor diversity by high-throughput TCR sequencing in immunized mice suggests the emergence of a broader CDR3 Vα2 repertoire in Treg-depleted mice. These results suggest that Tregs may play a role in the restriction of the CD4 T cell repertoire during an immune response, raising therefore the possibility that in addition to controlling the magnitude of an immune response, regulatory cells may also control the diversity of TCRs in response to antigen stimulation.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Smith, Trevor Robert Frank. "Modulation of CD4+ T cell responses by CD4+CD25+ regulatory T cells and modified T cell epitopes". Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11317.
Texto completoSommermeyer, Daniel. "Generation of dual T cell receptor (TCR) T cells by TCR gene transfer for adoptive T cell therapy". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16051.
Texto completoThe in vitro generation of T cells with a defined antigen specificity by T cell receptor (TCR) gene transfer is an efficient method to create cells for immunotherapy. One major challenge of this strategy is to achieve sufficiently high expression levels of the therapeutic TCR. As T cells expressing an endogenous TCR are equipped with an additional TCR, there is a competition between therapeutic and endogenous TCR. Before this work was started, it was not known which TCR is present on the cell surface after TCR gene transfer. Therefore, we transferred TCR genes into murine and human T cells and analyzed TCR expression of endogenous and transferred TCR by staining with antibodies and MHC-multimers. We found that some TCR have the capability to replace other TCR on the cell surface, which led to a complete conversion of antigen specificity in one model. Based on these findings we proposed the concept of ‘‘strong’’ (well expressed) and “weak” (poorly expressed) TCR. In addition, we found that a mouse TCR is able to replace both “weak” and “strong” human TCR on human cells. In parallel to this result, it was reported that the constant (C)-regions of mouse TCR were responsible for the improved expression of murine TCR on human cells. This led to a strategy to improve human TCR by exchanging the C-regions by their murine counterparts (murinization). However, a problem of these hybrid constructs is the probable immunogenicity. Therefore, we identified the specific parts of the mouse C-regions which are essential to improve human TCR. In the TCRalpha C-region four and in the TCRbeta C-region five amino acids were identified. Primary human T cells modified with TCR containing these nine “murine” amino acids showed an increased function compared to cells modified with wild type TCR. For TCR gene therapy the utilization of these new C-regions will reduce the amount of foreign sequences and thus the risk of immunogenicity of the therapeutic TCR.
Tyznik, Aaron Jacob. "CD4+ T cell help for CD8+ T cell responses /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8314.
Texto completoButcher, Sarah A. "T cell receptor genes of influenza A haemagglutinin specific T cells". Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315271.
Texto completoRaeiszadeh, Mohammad. "Reconstitution of CMV-specific T-cells following adoptive T-cell immunotherapy and haematopoietic stem cell transplantation". Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6968/.
Texto completoKanazawa, Nobuo. "Fractalkine and macrophage-derived chemokine : T cell attracting chemokines expressed in T cell area dendritic cells". Kyoto University, 2000. http://hdl.handle.net/2433/180886.
Texto completoThümmler, Katja. "Immune regulation through homotypic T cell, T cell interaction = Immunregulation durch homotypische T-Zell-T-Zell-Wechselwirkungen". kostenfrei, 2010. http://d-nb.info/100248281X/34.
Texto completoCrawford, A. "How B cells influence T cell responses". Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645118.
Texto completoFerreira, Cristina da Conceição Varandas. "Naive T cell survival : analysis of transgenic monoclonal T cell populations". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250701.
Texto completoLi, Xiaoying. "T cell receptor repertoires of immunodominant CD8 T cell responses to Theileria parva". Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/19552.
Texto completoLi, Ming 1957. "Generation of CD8+ T cell immunity with help from CD4+ T cells". Monash University, Dept. of Pathology and Immunology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8476.
Texto completoSoper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.
Texto completoNagai, Yuya. "T memory stem cells are the hierarchical apex of adult T-cell leukemia". Kyoto University, 2015. http://hdl.handle.net/2433/202670.
Texto completoMurray, Anna. "T cell clonality in coeliac disease and enteropathy associated T cell lymphoma". Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241223.
Texto completoNadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation". Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.
Texto completoMahajan, Simmi. "Development of T cell help for B cells". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/12548.
Texto completoMavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation". Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.
Texto completoBangs, Sarah Christine. "Bystander T cell activation". Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491311.
Texto completoChan, Chi Wei Cliburn. "Modelling T cell activation". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396213.
Texto completoAlsubki, R. A. "Editing T cell specificity". Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1561576/.
Texto completoLara, Oscar R. "Immunomagnetic cell separation further applications of the quadrupole magnetic cell sorter /". Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5fnum=osu1064338539.
Texto completoTitle from first page of PDF file. Document formatted into pages; contains xxi, 179 p.; also contains graphics (some col.). Includes abstract and vita. Advisor: Jeffrey, Dept. of Chemical Engineering. Includes bibliographical references (p. 160-169).
Cabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.
Texto completoWright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer". Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.
Texto completoSun, Joseph C. "The role of CD4 T cell help during the CD8 T cell response /". Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8334.
Texto completoPaiva, Ricardo de Sousa. "T cell Maturation and Regulatory T Cell Differentiation:From the Thymus to the Periphery". Doctoral thesis, Universidade Nova de Lisboa.Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/10587.
Texto completoDissertation presented to obtain the Ph.D degree in Immunology
Mofolo, Boitumelo. "Regulated T cell pre-mRNA splicing as genetic marker of T cell suppression". Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/3071.
Texto completoGozalo, Sara. "The Role of γс Cytokines in T Cell Development, T Cell Homeostasis and CD8+ T Cell Function: A Dissertation". eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/140.
Texto completoAloufi, Nawaf. "The role of sCD127 in IL-7-Mediated T Cell Homeostasis in Vivo". Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41089.
Texto completoChtanova, Tatyana Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "T cell transcriptomes: uncovering the mechanisms for T cell effector function through gene profiling". Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/22029.
Texto completoZarozinski, Christopher C. "T Cell Receptor-Dependent and Independent Events During Potent Anti-Viral T Cell Responses". eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/175.
Texto completoTibbitt, Christopher Andrew. "The role of T cell receptor signal intensity in T helper 17 cell development". Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2885.
Texto completoEnglish, Kieran. "Deciphering the cellular mechanisms promoting CD4+ T cell-dependent intrahepatic CD8+ T cell immunity". Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27735.
Texto completoFukunaga, Akiko. "Altered Homeostasis of CD4+ Memory T cells in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Chronic Graft-versus-Host Disease Enhances T cell Differentiation and Exhausts Central Memory T Cell Pool". Kyoto University, 2008. http://hdl.handle.net/2433/124214.
Texto completoJavorovic, Miran. "T-Cell Stimulation by Melanoma RNA-Pulsed Dendritic Cells". Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-30569.
Texto completoBansal, Raj Rani. "B cell help provided by human γδ T cells". Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/36649/.
Texto completoCrawford, Alison. "Role of B cells in influencing T cell responses". Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13483.
Texto completoMulati, Kumuluzi. "VISTA expressed in tumor cells regulates T cell function". Kyoto University, 2019. http://hdl.handle.net/2433/242370.
Texto completoXue, Yintong. "Glucocorticoid in T cell differentiation /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3950-0/.
Texto completoLovatt, Matthew. "Control of T cell selection". Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313597.
Texto completoSheu, Eric G. "Immunology of T cell vaccines". Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288552.
Texto completoLomas, Adrian John. "Poliovirus T cell epitope chimaeras". Thesis, University of Reading, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318621.
Texto completoDemetriou, Philippos. "Regulation of T cell activation". Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:a20d2d22-bdc8-407e-a9b5-57d18ae6948a.
Texto completoOpel, Cary F. (Cary Francis). "T cell mediated combination immunotherapy". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/107075.
Texto completoCataloged from PDF version of thesis. "September 2015."
Includes bibliographical references (pages 128-131).
Immunotherapy is a broad treatment strategy that harnesses the immune system to fight off a particular condition or disease. Cancer immunotherapy is the specific application of agents designed to interact or stimulate the immune system to fight off tumors. Treatments as diverse as passive antibody therapy, cytokine support, and comprehensive adoptive T cell transfer make up the broad field of immunotherapeutics. Due to the naturally complex interactions inherent in the immune system, there are many options for therapeutic intervention, however, this same complexity makes it extremely difficult to optimize treatment strategies. Because of this, research into developing new immunotherapies, optimizing existing immunotherapies, and designing new combinations of immunotherapies is still critical in the fight against cancer. Although there have been ongoing successes of individual immunotherapies in the clinic, the complexity and interdependence of the immune system suggests that any single therapeutic intervention will be insufficient to reject established malignancies. Increased interest in applying combinations of immunotherapies in the clinic requires more thorough preclinical work to guide the designs of these studies. The work presented in this thesis focuses on developing combinations of immunotherapies to treat preclinical models of cancer, as well as studying the underlying mechanism of tumor control. T cells are potent mediators of cytotoxicity and when properly used in adoptive cell transfer (ACT) protocols, can be highly effective in the treatment of cancer. ACT consists of three steps: 1) harvesting and purifying T cells from the patient, 2) enriching or modifying the T cells to become tumor specific, and 3) reinfusing the T cells along with supporting therapies. Therapies given alongside ACT are often adjuvants designed to enhance T cell response. However, focusing therapies only on enhancing the activity of the transferred T cells may miss out on synergistic effects when other parts of the immune system are simultaneously engaged. To study the effect of adjuvant therapy on ACT, a preclinical murine model was analyzed. Large, established B16F10 tumors were controlled when pmel-1 T cells were given with a course of supportive MSA-IL2 cytokine therapy, however, no cures were observed. When a course of TA99 antibody therapy was added alongside ACT, a high rate of cures was observed. Flow cytometry of both circulating and tumor infiltrating pmel-1 cells showed massive expansion and activation. Additionally, tumor infiltration of neutrophils, NK cells, and DCs were greatly enhanced by adjuvant therapy. DCs in the tumor draining lymph nodes were largely unchanged by the therapies. Engagement of the humoral immune response was also observed in both treatment cases. Surprisingly, antibody therapy did not substantially alter any of the mechanistic observations made in this study, despite its critical role in achieving cures of tumors. While ACT is a highly effective therapy, its clinical applicability is hindered by the complexity of performing T cell transplants and manipulations. A more optimal solution would involve purely injectable treatments that could elicit the same level of tumor specific T cell response in conjunction with potent recruitment of the adaptive immune system against tumors. To achieve this, working in collaboration with the Irvine Lab, combinations of immunotherapy using up to four different components were tested to identify critical factors in the successful rejection of established tumors in preclinical models. The four components of tumor targeting antibody, cytokine support, checkpoint blockade, and cancer vaccine acted synergistically to reject tumors from B16F10, TC-1, and DD-Her2/neu cell lines. The cancer vaccine elicited large numbers of tumor-specific T cells, and acted as a replacement for ACT. By analyzing subset combinations of this full treatment, the roles of each therapeutic component were identified. CD8 T cells and cross-presenting DCs were critical to curing subcutaneous tumors. Cytokine therapy was indispensable for effective tumor control, promoted immune cell infiltration into the tumor, and led to an increase in DCs. In combination with the other therapies, vaccination against a tumor antigen elicited a strong immunological memory response that was able to reject subsequent tumor rechallenge, as well as promote antigen spreading to new epitopes. Successful combinations were demonstrated to be dependent on the recruitment of both the adaptive and innate branches of the immune system. Finally, the efficacy of this combination of treatments was demonstrated by controlling the growth of induced tumors in a BRaf/Pten model. Combination immunotherapy promises a future where synergistic treatments are specifically tailored to individual cancers leading to highly effective responses. However, determining the optimal combination of therapies, the complexity of dosing strategies, and the availability of targeted treatments are all barriers that must be overcome. The analysis presented here will make a significant contribution to the body of knowledge on immunotherapy as it has shown the importance of combining orthogonal immunotherapies in order to get durable cures to established tumors. These results will hopefully encourage combinations of orthogonally acting therapies based on T cells to achieve stronger clinical responses. By determining the necessary requirements for a strong, synergistic response to tumorous growths, more effective combination immunotherapy protocols may be designed in the future.
by Cary F. Opel.
Ph. D.
Cornish, Georgina. "Regulation of T cell growth". Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446301/.
Texto completoTrüb, Marta. "Follicular T helper cell populations". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20466.
Texto completoTigno-Aranjuez, Justine Daphne Tiglao. "Adjuvant Guided T cell Responses". Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244035297.
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