Tesis sobre el tema "Synthèse HLS"
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Vijayaraghavan, Vijay P. "Exploration des liens entre la synthèse de haut niveau (HLS) et la synthèse au niveau transferts de registres (RTL)". Grenoble INPG, 1996. http://www.theses.fr/1996INPG0184.
Texto completoPayet, Matthieu. "Conception de systèmes programmables basés sur les NoC par synthèse de haut niveau : analyse symbolique et contrôle distribué". Thesis, Lyon, 2016. http://www.theses.fr/2016LYSES051/document.
Texto completoNetwork-on-Chip (NoC) introduces parallelism in communications and emerges with the growing integration of circuits as large designs need scalable communication architectures. This introduces the separation between communication tasks and processing tasks, and makes the design with NoC more complex. High level synthesis (HLS) tools can help designers to quickly generate high quality HDL (Hardware Description Level) designs. But their control schemes are centralized, usually using finite state machines. To take benefit from parallel algorithms and the ever growing FPGAs, HLS tools must properly extract the parallelism from the input representation and use the available resources efficiently. Algorithm designers are used with programming languages. This behavioral specification has to be enriched with architectural details for a correct optimization of the generated design. The C to FPGA path is not straightforward, and the need for architectural knowledges limits the adoption of FPGAs, and more generally, parallel architecture. In this thesis, we present a method that uses a symbolic analysis technique to extract the parallelism of an algorithmic specification written in a high level language. Parallelization skills are not required from the users. A methodology is then proposed for adding NoCs in the automatic design generation that takes the benefit of potential parallelizations. To dimension the design, we estimate the design resource consumption using a mathematical model for the NoC. A scalable application, hardware specific, is then generated using a High Level Synthesis flow. We provide a distributed mechanism for data path reconfiguration that allows different applications to run on the same set of processing elements. Thus, the output design is programmable and has a processor-less distributed control. This approach of using NoCs enables us to automatically design generic architectures that can be used on FPGA servers for High Performance Reconfigurable Computing. The generated design is programmable. This enable users to avoid the logic synthesis step when modifying the algorithm if a existing design provide the needed operators
Ribon, Aurélien. "Amélioration du processus de vérification des architectures générées à l'aide d'outils de synthèse de haut-niveau". Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14719/document.
Texto completoThe fast growing complexity of hardware circuits, during the last three decades, has change devery step of their development cycle. Design methods evolved a lot, and this evolutionwas necessary to cope with an always shorter time-to-market, mainly driven by the internationalcompetition.An increased complexity also means more errors, harder to find corner-cases, and morelong and expensive simulations. The verification of hardware systems requires more andmore resources, and is the main cost factor of the whole development of a circuit. Since thecomplexity of any system increases, the cost of an error undetected until the foundry stepbecame prohibitive. Therefore, the verification process is divided between multiple stepsinvolved at every moment of the design process : comparison of models behavior, simulationof RTL descriptions, formal analysis of algorithms, assertions usage, etc. The verificationmethodologies evolved a lot, in order to follow the progress of design methods. Somemethods like the Assertion-Based Verification became so important that they are nowwidely adopted among the developers community, providing near-source error detection.Thus, the work described here aims at improving the assertion-based verification process,in order to offer a consequent timing improvment to designers. Two contributions aredetailed. The first one deals with the transformation of Boolean assertions found in algorithmicdescriptions into equivalent temporal assertions in the RTL description generatedby high-level synthesis (HLS) methodologies. Therefore, the assertions are usable duringthe simulation process of the generated architectures. The second contribution targets theverification of hardware systems in real-time. It details the synthesis process of a hardwareerror manager, which has to save and serialize the execution context when an error isdetected. Thus, it is easier to understand the cause of an error and to find its source. Theerrors and their contexts are serialized as reports in a memory readable by the system ordirectly by the designer. The behavior of a circuit can be analyzed without requiring anyprobe or integrated logic analyzer
Diakité, Daouda. "High-level synthesis (HLS) on FPGA for inverse problems : application to tomography and radioastronomy". Electronic Thesis or Diss., université Paris-Saclay, 2022. http://www.theses.fr/2022UPASG080.
Texto completoThe increasing need for computing power imposed by the complexity of processing algorithms and the size of problems requires using hardware accelerators to meet time and energy constraints. FPGA architectures are known to be among the most power-efficient platforms, especially for embedded systems using hardware description languages. The appearance of the new high-level synthesis tools has been a major factor in the consideration of FPGAs for complex applications, as is the case with the manycores processors. The high-level synthesis tools generate a hardware description design from high-level languages such as C, C++, or OpenCL. The recent FPGAs are equipped with several floating-point computing units capable of meeting the precision requirements of a wide range of applications. However, exploiting the full potential of these architectures has always been a major concern. This thesis aims to explore methodologies for accelerating inverse problem algorithms on FPGA architectures through new high-level synthesis tools applied to tomographic reconstruction and radioastronomy. Indeed, many algorithms for these applications are memory-bound. A custom architecture derived from an algorithm-architecture co-design methodology has been proposed to overcome the memory bottleneck. We applied this methodology to the 3D back-projection operator in the context of iterative reconstruction. The 3D back-projector architecture takes advantage of a custom memory access strategy to reach a full computational throughput. Then we consider the parallelization of the complete optimization algorithm on FPGA. We also discuss the position of FPGAs in radio astronomy, particularly for the SKA pipeline imaging system
Thievenaz, Hugo. "Scalable Trace-based Compile-Time Memory Allocation". Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0108.
Texto completoThis thesis, titled “Scalable trace-based compile-time memory allocation”, studies the use of dynamic analysis to infer memory footprint reductions. The broader goal is to use program information at run-time as a way to outpace traditional static analysis techniques, because the latter often fail to scale for kernels of high dimensions and many statements.The research methodology involved studying state-of-the-art methods in “array contraction”, a compilation optimization that aims to reduce the allocated storage space; Then, rebuilding them both theoretically and in practice, by constructing proofs of the new algorithms and their implementations to quantify performance in analysis time but also memory reduction. The example programs used for performance measurement were variations of the well-known benchmark suite “PolyBench”. The variations are most often parallelism factor, tiling, and adjustment of padding.Key contributions of this thesis are the design of two new methods of analysis for the “array contraction” optimization. The first one focuses on yielding constant sizes for temporary arrays, which is relevant in the context of communication buffer sizing for High-Performance Computing applications. The second method is a more general approach to memory allocation which reconstructs several iterations of a data structure describing the arrays’ used cells, to produce parametric sizes for the arrays.This research lead to the implementation of a tool named PoLa that totals around 4000 lines of C++ code
Badier, Hannah. "Transient obfuscation for HLS security : application to cloud security, birthmarking and hardware Trojan defense". Thesis, Brest, École nationale supérieure de techniques avancées Bretagne, 2021. https://tel.archives-ouvertes.fr/tel-03789700.
Texto completoThe growing globalization of the semiconductor supply chain, as well as the increasing complexity and diversity of hardware design flows, have lead to a surge in security threats: risks of intellectual property theft and reselling, reverse-engineering and malicious code insertion in the form of hardware Trojans during manufacturing and at design time have been a growing research focus in the past years. However, threats during highlevel synthesis (HLS), where an algorithmic description is transformed into a lower level hardware implementation, have only recently been considered, and few solutions have been given so far. In this thesis, we focus on how to secure designs during behavioral synthesis using either a cloud-based or an internal but untrusted HLS tool. We introduce a novel design time protection method called transient obfuscation, where the high-level source code is obfuscated using key-based techniques, and deobfuscated after HLS at register-transfer level. This two-step method ensures correct design functionality and low design overhead. We propose three ways to integrate transient obfuscation in different security mechanisms. First, we show how it can be used to prevent intellectual property theft and illegal reuse in a cloud-based HLS scenario. Then, we extend this work to watermarking, by exploiting the side-effects of transient obfuscation on HLS tools to identify stolen designs. Finally, we show how this method can also be used against hardware Trojans, both by preventing insertion and by facilitating detection
Ben, Jmaa Chtourou Yomna. "Implémentation temps réel des algorithmes de tri dans les applications de transports intelligents en se basant sur l'outil de synthèse haut niveau HLS". Thesis, Valenciennes, 2019. http://www.theses.fr/2019VALE0013.
Texto completoIntelligent transport systems play an important role in minimizing accidents, traffic congestion, and air pollution. Among these systems, we mention the avionics domain, which uses in several cases the sorting algorithms, which are one of the important operations for real-time embedded applications. However, technological evolution is moving towards more and more complex architectures to meet the application requirements. In this respect, designers find their ideal solution in reconfigurable computing, based on heterogeneous CPU / FPGA architectures that house multi-core processors (CPUs) and FPGAs that offer high performance and adaptability to real-time constraints. Of the application. The main objective of my work is to develop hardware implementations of sorting algorithms on the heterogeneous CPU / FPGA architecture by using the high-level synthesis tool to generate the RTL design from the behavioral description. This step requires additional efforts on the part of the designer in order to obtain an efficient hardware implementation by using several optimizations with different use cases: software, optimized and nonoptimized hardware and for several permutations / vectors generated using the generator pf permutation based on Lehmer method. To improve performance, we calculated the runtime, standard deviation and resource number used for sorting algorithms by considering several data sizes ranging from 8 to 4096 items. Finally, we compared the performance of these algorithms. This algorithm will integrate the applications of decision support, planning the flight plan
Ben, Hammouda Mohamed. "A design flow to automatically Generate on chip monitors during high-level synthesis of Hardware accelarators". Thesis, Brest, 2014. http://www.theses.fr/2014BRES0115/document.
Texto completoEmbedded systems are increasingly used in various fields like transportation, industrial automation, telecommunication or healthcare to execute critical applications and manipulate sensitive data. These systems often involve financial and industrial interests but also human lives which imposes strong safety constraints.Hence, a key issue lies in the ability of such systems to respond safely when errors occur at runtime and prevent unacceptable behaviors. Errors can be due to natural causes such as particle hits as well as internal noise, integrity problems, but also due to malicious attacks. Embedded system architecture typically includes processor (s), memories, Input / Output interface, bus controller and hardware accelerators that are used to improve both energy efficiency and performance. With the evolution of applications, the design cycle of hardware accelerators becomes more and more complex. This complexity is partly due to the specification of hardware accelerators traditionally based on handwritten Hardware Description Language (HDL) files. However, High-Level Synthesis (HLS) that promotes automatic or semi-automatic generation of hardware accelerators according to software specification, like C code, allows reducing this complexity.The work proposed in this document targets the integration of verification support in HLS tools to generate On-Chip Monitors (OCMs) during the high-level synthesis of hardware accelerators (HWaccs). Three distinct contributions are proposed. The first one consists in checking the Input / Output timing behavior errors (synchronization with the whole system) as well as the control flow errors (illegal jumps or infinite loops). On-Chip Monitors are automatically synthesized and require no modification in their high-level specification. The second contribution targets the synthesis of high-level properties (ANSI-C asserts) that are added into the software specification of HWacc. Synthesis options are proposed to trade-off area overhead, performance impact and protection level. The third contribution improves the detection of data corruptions that can alter the stored values or/and modify the data transfers without causing assertions violations or producing illegal jumps. Those errors are detected by duplicating a subset of program’s data limited to the most critical variables. In addition, the properties over the evolution of loops induction variables are automatically extracted from the algorithmic description of HWacc. It should be noticed that all the proposed approaches, in this document, allow only detecting errors at runtime. The counter reaction i.e. the way how the HWacc reacts if an error is detected is out of scope of this work
Rubattu, Claudio. "Response time analysis of parameterized dataflow applications on heterogeneous SW/HW systems". Thesis, Rennes, INSA, 2020. http://www.theses.fr/2020ISAR0005.
Texto completoIn contexts such as embedded and cyber-physical systems, the design of a desired functionality under constraints increasingly requires a parallel execution of different tasks on heterogeneous architectures. The nature of such parallel systems implies a huge complexity in understanding and predicting performance in terms of response time. Indeed, response time depends on many factors associated with the characteristics of both the functionality and the target architecture. State-of-the art strategies derive response time by examining the operations required by each task for both processing and accessing shared resources. This procedure is often followed by the addition or elimination of potential interferences due to task concurrency. However, such approaches require an advanced knowledge of the software and hardware details, rarely available in practice. This thesis provides an alternative "topdown" strategy aimed at extending the cases in which hardware and software response times can be analyzed and predicted. The proposed strategy leverages on dataflow-based application representations and focuses on the response time estimation of reconfigurable applications mapped on both general-purpose and specialized processing elements
Ye, Haixiong. "Impact des transformations algorithmiques sur la synthèse de haut niveau : application au traitement du signal et des images". Phd thesis, Université Paris Sud - Paris XI, 2014. http://tel.archives-ouvertes.fr/tel-01061200.
Texto completoChavet, Cyrille. "Synthèse automatique d'interfaces de communication matérielles pour la conception d'applications du domaine du traitement du signal". Phd thesis, Université de Bretagne Sud, 2007. http://tel.archives-ouvertes.fr/tel-00369043.
Texto completoCasabon, Israël. "Synthèse de HPr(Ser-P)(His~P) chez Streptococcus Salivarius". Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27177/27177.pdf.
Texto completoBranchet, Marie-Christine. "Étude des fibroblastes et de la synthèse du collagène dans les sclérodermies". Paris 12, 1990. http://www.theses.fr/1990PA120034.
Texto completoSalembier, Hélori. "Développement de catalyseurs supportés pour la synthèse directe du méthylmercaptan à partir de CO/H2/H2S et CO2/H2/H2S". Thesis, Lille 1, 2017. http://www.theses.fr/2017LIL10207.
Texto completoIn the field of chemistry, industrial research is committed to the development of environmentally friendly synthesis strategies. Methyl mercaptan (CH3SH) is a precursor to methionine whose worldwide demand is steadily growing. It is currently produced by a catalytic reaction between H2S and methanol. Due to the production of methanol involving multiple reaction steps, the direct synthesis of methyl mercaptan from syngas (CO/H2) and H2S or from (CO2/H2) and H2S (assuming a CO2 recycling) appears as a financially attractive industrial process. This work focused on the development of new catalysts for this reaction, specifically on identifying and quantifying the active phase of different catalytic systems. Studies on the effects of molybdenum loading, calcination procedures and copper and/or zinc doping were carried out on an alumina-supported potassium-molybdenum catalyst. Others metal oxide carriers were also employed, remarkably improving catalytic performances. Catalytic tests were performed with a micro-pilot reactor operated in near-industrial conditions. Catalysts were characterized using X-ray photoelectron spectroscopy, transmission emission microscopy, X-ray diffraction and Raman spectroscopy, evidencing the presence of a significant lamellar 1T-MoS2 type phase, intercalated by potassium ions. Quantification of this intercalated phase was correlated with methyl mercaptan productivity, demonstrating its role as the catalytically active phase which drives methyl mercaptan direct synthesis
Beckmann, Udo. "Synthese und Charakterisierung von Eisen-, Cobalt- und Galliumkomplexen mit den redoxaktiven Amidligandsystemen Pyridincarboxamidobenzol und Hydroxyphenyloxamid". Mühlheim an der Ruhr : Max-Planck-Institut für Strahlenchemie, 2001. http://www-brs.ub.ruhr-uni-bochum.de/netahtml/HSS/Diss/BeckmannUdo/diss.pdf.
Texto completoFaqihi, Fatima-Ezzahra. "Etudes des interactions CMH/peptide/TCR : rôle des acides aminés polymorphes de la chaîne HLA-bêtaDR dans la présentation de peptides viraux et lors de l'alloréaction". Toulouse 3, 1995. http://www.theses.fr/1995TOU30047.
Texto completoTahri, Abdelali. "Propriétés électriques et réactivité du molybdate de nickel NiMoO4 synthétisé par réaction solide-solide : étude de la réduction (H2) et de la sulfuration (H2S/H2) par thermogravimétrie". Dijon, 1991. http://www.theses.fr/1991DIJOS018.
Texto completoShrivastwa, Ritu Ranjan. "Enhancements in Embedded Systems Security using Machine Learning". Electronic Thesis or Diss., Institut polytechnique de Paris, 2023. http://www.theses.fr/2023IPPAT051.
Texto completoThe list of connected devices (or IoT) is growing longer with time and so is the intense vulnerability to security of the devices against targeted attacks originating from network or physical penetration, popularly known as Cyber Physical Security (CPS) attacks. While security sensors and obfuscation techniques exist to counteract and enhance security, it is possible to fool these classical security countermeasures with sophisticated attack equipment and methodologies as shown in recent literature. Additionally, end node embedded systems design is bound by area and is required to be scalable, thus, making it difficult to adjoin complex sensing mechanism against cyberphysical attacks. The solution may lie in Artificial Intelligence (AI) security core (soft or hard) to monitor data behaviour internally from various components. Additionally the AI core can monitor the overall device behaviour, including attached sensors, to detect any outlier activity and provide a smart sensing approach to attacks. AI in hardware security domain is still not widely acceptable due to the probabilistic behaviour of the advanced deep learning techniques, there have been works showing practical implementations for the same. This work is targeted to establish a proof of concept and build trust of AI in security by detailed analysis of different Machine Learning (ML) techniques and their use cases in hardware security followed by a series of case studies to provide practical framework and guidelines to use AI in various embedded security fronts. Applications can be in PUFpredictability assessment, sensor fusion, Side Channel Attacks (SCA), Hardware Trojan detection, Control flow integrity, Adversarial AI, etc
Schulz, Lisa [Verfasser]. "Die Rolle der Glykogen-Synthase-Kinase 3 in Plattenepithelkarzinomen des Kopf-Hals-Bereiches / Lisa Schulz". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2018. http://d-nb.info/1152033379/34.
Texto completoOliveira, De Souza Danilo. "Quick-EXAFS and hydrotreating catalysts : chemometrics contribution". Thesis, Lille 1, 2015. http://www.theses.fr/2015LIL10061/document.
Texto completoHydrodesulfurization (HDS) is catalytic process used to remove sulfur from petroleum feedstock. The world claim for clean fuel boosted scientists to get new insights on the catalytic reaction in order to understand the mechanisms of the process and, thus, produce catalysts that are more efficient. Such researches are based mainly in to lines: by one hand, in the formulation of new routes that lead to tailored catalysts and, by the other hand, in a better understanding of the catalytic process at the molecular and atomic level. Particularly, the later leads to an optimization of the formulation and better catalytic performance, for which is required further understanding of the molecular structure, its transformations during the reaction, the nature of active species and its genesis. In this picture, the goal of this work is twofold. First, to present a new route for produce HDS CoMo-based catalysts via one-pot sol-gel method, which revealed to have suitable macro- and microscopic properties making promising solids for further applications. Second, to adapt and use chemometrics method to treat in situ measurements, particularly, X-ray absorption spectra (XAS), to get new insights on the genesis of the catalytic active phase at the molecular level. XAS techniques is suitable to probe local atomic structure, and last generation synchrotron facilities provide conditions to perform such in situ experiments with very fast acquisition (Quick-EXAFS). Chemometrics provide a brand new scope on data analysis and interpretation for extract information on the kinetics of reaction and structure transformation that leads to the active phase of the catalysts
Wahbi, Mernissi Khalid. "Étude exploratoire du système AG-HG-S : Synthèse de l'imitérite AG::(2)HGS::(2) stabilité thermique, caractérisation électrique et optique". Nancy 1, 1989. http://www.theses.fr/1989NAN10090.
Texto completoNeveux, Laure. "Étude de la cinétique et du mécanisme de sulfuration de ZnO par H2S". Phd thesis, Ecole Nationale Supérieure des Mines de Saint-Etienne, 2011. http://tel.archives-ouvertes.fr/tel-00785650.
Texto completoLarabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.
Texto completoThe aim of the present work was to develop two analytical approaches dedicated to the analysis of new psychoactive substances in different biological matrices (blood, urine and hair). The first approach is based on untargeted screening by both biochip array technology chemiluminescence assay and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and the second corresponds to a targeted screening by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These two approaches were then applied in observational studies to assess the consumption of NPS in high risk populations (overdose, drug abuse, drug facilitated crimes) in clinical and forensic settings. The last part of the work was devoted to the development of a new analytical tool for LC-HRMS data processing which made it possible to study the metabolism of 9 NPS In vitro on human liver microsomes (HLM) and In vivo in biological samples from drug users. This approach has enabled the creation of HRMS spectral library containing 228 metabolites, some of which have been proposed as relevant markers of NPS exposure.This work has resulted on 10 scientific publications and allowed to initiate many multidisciplinary collaborations
Cornille, Fabrice. "Etude des interactions entre peptides et molécules de classe I du complexe majeur d'histocompatibilité, synthèse et étude physicochimique de la protéine de nucléocapside NCp10 du rétrovirus MoMuLU". Paris 5, 1991. http://www.theses.fr/1991PA05P604.
Texto completoAbudukadier, Abulizi. "Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice". Kyoto University, 2013. http://hdl.handle.net/2433/180462.
Texto completoZhang, Chengda. "SYNTHESES OF PEG/ALKYL-BASED IMIDAZOLIUM/PYRIDINIUM IONIC LIQUIDS AND APPLICATIONS ON H2S ABSORPTION& SYNTHESES OF POLYSULFONE BASED FUNCTIONALIZED IMIDAZOLIUM IONIC POLYMERS AND APPLICATIONS ON GAS SEPARATION". OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1797.
Texto completoKrebs, Stefan Ralf. "Nonnatural ligands for the human leukocyte antigen HLA-B27 : protein expression, site-directed mutagenesis, peptide syntheses and binding studies". Zürich, 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12426.
Texto completoHynaux, Amélie. "Synthèse et caractérisation de carbures de molybdène supportés sur composite de noir de carbone mésoporeux : application en hydrodésulfuration du dibenzothiophène et en hydrodésazotation de l'indole". Paris 6, 2005. http://www.theses.fr/2005PA066096.
Texto completoVracar, Radivoje. "Développement de matériaux Mg2Si1-xSnx de type n et p pour applications thermoélectriques dans la gamme de température 300-600 °C". Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENI109.
Texto completoN and P type Mg-Si-Sn and Mn-Si alloys have been investigated for thermoelectrical applications in the 20-600 °C temperature range. To manufacture dense sintered samples, only two steps have been used: mechanical-alloying followed by spark plasma sintering.By optimizing the processing conditions it was possible to obtain an n-Type Mg2Si0.4Sn0.6 material exhibiting a ZT parameter of 1.2 at 500 °C. By adding Half-Heusler nanoparticles to a Mg2Si0.4Sn0.6 matrix, it was shown that the ZT parameter is increased to 1.4 at 500 °C. Then strong links have been established between the processing parameters, the thermoelectrical properties and the sintered microstructure (use of transmission electron microscopy).The investigations performed on a p-type MnSi1.75 material are only preliminary ones. Nonetheless, always by tailoring the processing conditions, it was possible to obtain a sintered material exhibiting a ZT parameter of 0.45 at 575 °C
Barreiro, Portela Esther. "Study of reactive oxygen species (ROS) and nitric oxide (NO) as molecular mediators of the sepsis-induced diaphragmatic contractile dysfunction : protective effect of heme oxygenases". Doctoral thesis, Universitat Pompeu Fabra, 2002. http://hdl.handle.net/10803/7066.
Texto completoEn un model de sepsi de disfunció diafragmàtica, s´ha avaluat el paper de les sintetases de l'òxid nítric (NOS) en la formació i localitzacio de 3-nitrotirosina, i l´expressió i significat biològic de les hemo oxigenases (HOs) (inhibidor de les HOs i estudis de contractilitat) davant l' estrès oxidatiu. La sepsi s'induí mitjançant injecció de 20 mg/kg del lipolisacàrid (LPS) d´Escherichia Coli a rates, i a ratolins deficients en les NOS induïble (iNOS), neuronal (nNOS) i endotelial (eNOS). Les proteïnes nitrificades i les HOs es van detectar amb anticossos específics. L' estrès oxidatiu s' avaluà mitjançant l' oxidació proteica, la peroxidació lipídica i el glutation muscular. Concloem que hi han proteïnes nitrificades en el múscul normal i aquestes s'incrementen durant la sepsi en les fraccions mitocondrial i membranar. L'isoforma iNOS és majorment responsable de la formació de nitrotirosina. Les HOs protegirien el múscul normal i sèptic dels efectes deleteris dels oxidants.
Ameline, Alice. "Aspects analytiques, cliniques et médico-judiciaires des nouvelles substances psychoactives". Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ018/document.
Texto completoDue to the uncontrolled spread on the Internet and their legal alternative to usual drugs, the new psychoactive substances (NPS), recently appeared (2008), are at the center of recent phenomena of addiction and badly explained deaths. Beyond different challenges in our societies (prevention, legislation), the ability to identify NPS in biological samples, in order to characterize their use, presents many analytical challenges. The main objective of this thesis was to collect biological samples (blood, urine, hair) from cases of exposure to NPS and to characterize the substances present using original analytical methods, in order to enlarge the libraries of mass spectra and improve, as a result, the detection of NPS consumption. In particular, it was intended to increase the detection sensitivity of NPS intake by focusing on the metabolites that are often the major products of elimination. This analytical development, by ultra-high liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), required several months of optimization in order to obtain a robust, exhaustive and sensitive method. At present, the mass spectra database has 114 NPS and is regularly updated. Thereafter, ma thesis focused on the study of cases of intoxication observed in the emergency department of Strasbourg, but also in legal medicine with situations of deaths and identification of unknown products collected from seizures (powders and crystals). It has also been necessary to implement complementary analytical tools, such as the characterization of metabolites by human liver microsomes (HLMs), and the use of nuclear magnetic resonance (NMR) spectroscopy to accurately identify the compounds and establish their purity degrees. The analytical tools developed, and the strategy adopted, allowed the writing of 18 publications, as well as the setting up of numerous collaborations
VIJAYARAGHAVAN, V. "Exploration des liens entre la synthèse de haut niveau (HLS) et la synthèse au niveau transferts de registres (RTL)". Phd thesis, 1996. http://tel.archives-ouvertes.fr/tel-00010764.
Texto completoGutierres, André Luís Teixeira. "Structural and functional studies on human enzymes involved in hydrogen sulfide breakdown". Master's thesis, 2016. http://hdl.handle.net/10362/19981.
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