Tesis sobre el tema "Structural virology"
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Sabaratnam, Keshalini. "The interaction between the Marek's Disease Virus (MDV) neurovirulence factor pp14 and the host transcription factor, CREB3". Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:d2fc6bd4-bc3a-4a37-924b-86881096a9b5.
Texto completoConley, Michaela Jayne. "Structural and functional characterisation of feline calicivirus entry". Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8920/.
Texto completoThompson, Catherine Isabelle. "Protein interaction studies on the rotavirus non-structural protein NSP1". Thesis, University of Warwick, 1999. http://wrap.warwick.ac.uk/80266/.
Texto completoRezelj, Veronica Valentina. "Characterization of the non-structural (NSs) protein of tick-borne phleboviruses". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8149/.
Texto completoHoward, Susan Teresa. "Structural and functional analyses on the SalI G fragment of vaccinia virus". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386088.
Texto completoMartin, Morgan Mackensie. "Functional analysis of hepatitis C virus non-structural protein (NS) 3 protease and viral cofactor NS4A". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1522.
Texto completoLauder, Rebecca Pink. "Structural analysis of adenovirus bound to blood coagulation factors that influence viral tropism". Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2636/.
Texto completoLeigh, Kendra Elizabeth. "Structural Studies of a Subunit of the Murine Cytomegalovirus Nuclear Egress Complex". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226065.
Texto completoRuiz, Arroyo Víctor Manuel. "Structural and functional analysis of Zika Virus NS5 protein". Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671922.
Texto completoEl virus Zika (ZIKV) pertenece a la familia Flaviviridae y constituye una amenaza para la salud pública, especialmente debido a las malformaciones provocadas en neonatos. Los flavivirus presentan un genoma RNA de simple cadena con polaridad positiva, flanqueado por regiones no traducidas (UTR) que presentan una elevada estructura secundaria, seguido de una región codificante para una única poliproteína que por proteólisis dará lugar a tres proteínas estructurales (C, prM, E) y cinco proteinas no estructurales (NS1-5). En el extremo C-terminal se encuentra la proteina NS5 que presenta actividad ARN polimerasa dependiente de ARN (RdRP) y un dominio metil-transferasa (MTase) para copiar el genoma y añadir una caperuza al extremo 5’ del nuevo ARN sintetizado, respectivamente. Dado el papel crucial de este enzima en la replicación viral, la proteina NS5 constituye una diana antiviral muy atractiva para inhibir la replicación del virus. En este estudio, determinamos la estructura de la proteína NS5 de ZIKV, usando cristalografía de Rayos-X combinada con diferentes técnicas biofísicas para caracterizar la organización supramolecular de la proteína. Identificamos las interacciones monomero-monomero y dimero-dimero para caracterizar las estructuras fibrilares de la proteína y evaluamos los efectos de la dimerización en la actividad polimerasa in-vitro. También evaluamos los efectos de la oligomerización de NS5 in-vivo en embriones de pollo, estableciendo una conexión entre esta proteína y la aparición de microcefalia en fetos infectados. Una de las estructuras de ARN más importantes presentes en el 5’UTR del genoma de los flavivirus es el 5SLA. Previamente se describió que esta estructura se unía a NS5 y actuaba como un promotor, siendo ademas esencial para la replicación viral. Medimos y optimizamos la estabilidad del complejo NS5-5SLA mediante técnicas biofísicas y bioquímicas y determinamos la estructura del complejo mediante cryo-EM. Las comparaciones entre la estructura cristalográfica y cryo-EM de NS5 revelaron, por primera vez en flavivirus, cambios conformacionales importantes en el dominio RdRP. Identificamos los residuos implicados en la formación del complejo y caracterizamos el efecto de la unión de NS5 a 5SLA sobre su actividad polimerasa. Estos resultados arrojan nueva luz para entender los mecanismos de replicación en los flavivirus.
Rainsford, Edward. "Functional studies on the rotavirus non-structural proteins NSP5 and NSP6". Thesis, University of Warwick, 2005. http://wrap.warwick.ac.uk/53876/.
Texto completoHalldorsson, Steinar. "Molecular determinants of phleboviral cell entry". Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:56c5ef37-b023-4a8f-bdf2-8388226dc3b3.
Texto completoArnaud, Charles-Adrien. "Structure de la queue du phage T5 et mécanisme de perforation de l’enveloppe bactérienne par les Siphoviridae". Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV086/document.
Texto completoThe vast majority (96%) of bacteriophages possess a tail that allows host cell recognition, cell wall perforation and safe viral DNA channelling from the capsid to the cytoplasm of the bacterium. Siphoviridae is a familly representing 60% of all tailed phages characterized by a long flexible tail. The tail tube is formed by stacks of hexamers of the tail tube protein (TTP) polymerised around the tape measure protein (TMP). At the distal end of the tail, the tail tip complex harbours the receptor binding proteins (RBP). For these phages, little is known on the mechanism that triggers DNA ejection after binding to the host.We report the crystal structure at 2.2 Å resolution of pb6, an unusual trimeric TTP, of siphophage T5. Structure analysis however confirms the homology of pb6 with all TTPs, related tube proteins of bacterial puncturing devices (type VI secretion system and R-pyocin) and procapsid proteases. We fit this structure into the cryo-electron microscopy map of the tail tube determined at 6 Å resolution. Comparing the structure of the tail tube before and after interaction with the host receptor, we show that unlike previously proposed, the host binding information is not propagated to the capsid by the tail tube, as the two structures, at that resolution, are identical. An ambitious NMR comparative study of the TTP in its monomeric and tube form is underway to further describe this assembly.Moreover, the structures of the tail tip complex prior and after interaction with the bacterial receptor were solved at intermediate resolution. These structures reveal interesting conformationnal changes triggered by the RBP binding to the bacterial receptor. Those rearrangements are the first to occur after phage irreversible binding to its host and they induce the TMP ejection, the capsid opening, the enveloppe perforation and ultimately DNA channeling to the host cytoplasm.Together with biochemical data and comparison with other known system in the litterature we are able to propose a model for Siphoviridae very first steps of infection. These findings might be of interest for the mechanism of other viral familly (notably Myoviridae) and similarity with other membrane perforating systems is discussed
Zwart, Lizahn. "Investigating two AHSV non-structural proteins : tubule-forming protein NS1 and novel protein NS4". Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/62198.
Texto completoDissertation (MSc)--University of Pretoria, 2013.
Genetics
MSc
Unrestricted
Koneru, Pratibha Chowdary. "Mechanistic and Structural Investigations into the Mode of Action of Allosteric HIV-1 Integrase Inhibitors". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1560532618539888.
Texto completoMeek, Richard William. "Structural and functional analysis of proteins involved in the C-DI-GMP network of the predatory bacterium Bdellovibrio bacteriovirus". Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8115/.
Texto completoChauché, Caroline Marie. "Molecular evolution of equine influenza virus non-structural protein 1". Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/8877/.
Texto completoHill, Alison. "Emergence of simian immunodeficiency virus in rhesus macaques is characterized by changes in structural and accessory genes that enhance fitness in the new host species". Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493400.
Texto completoMedical Sciences
Kissel, Jay D. "Target specificity and structural characterization of single-stranded DNA aptamer RT1t49, a broad inhibitor of HIV-1 reverse transcriptases". [Bloomington, Ind.] : Indiana University, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3274917.
Texto completoSource: Dissertation Abstracts International, Volume: 68-07, Section: B, page: 4320. Adviser: Donald H. Burke-Aguero. Title from dissertation home page (viewed Apr. 22, 2008).
Persson, Magnus. "Structural Studies of Bacteriophage PRR1 and HIV-1 protease". Doctoral thesis, Uppsala universitet, Strukturell molekylärbiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135159.
Texto completoFelaktigt tryckt som Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 724
Brown, Heather Piehl. "Homology-based Structural Prediction of the Binding Interface Between the Tick-Borne Encephalitis Virus Restriction Factor TRIM79 and the Flavivirus Non-structural 5 Protein". University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1481304908426729.
Texto completoStone, Nicholas P. "Elucidating the structural mechanisms of capsid stability and assembly using a hyperthermophilic bacteriophage". eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1042.
Texto completoZeng, Yingying. "Modeling and structural studies of single-stranded RNA viruses". Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47630.
Texto completoWhelan, Jillian Nicole. "Investigation of Respiratory Syncytial Virus Structural Determinants and Exploitation of the Host Ubiquitin System". Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6431.
Texto completoFadda, Valeria. "Structural studies on a hepatitis C virus-related immunological complex and on Ebola virus polymerase cofactor VP35". Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7703.
Texto completoFlatt, Justin Wayne. "STRUCTURAL INSIGHTS INTO RECOGNITION OF ADENOVIRUS BY IMMUNOLOGIC AND SERUM FACTORS". Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1387451692.
Texto completoHengrung, Narin. "Structure of the RNA-dependent RNA polymerase from influenza C virus". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:694e16a6-f94e-4375-a1f9-7e250aea7343.
Texto completoMinoves, Marie. "Etude fonctionnelle et structurale de la glycoprotéine du virus de la Stomatite Vésiculaire et des Lyssavirus". Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL068.
Texto completoVesicular stomatitis virus (VSV), an enveloped virus, is the prototype species of the genus Vesiculovirus within the family Rhabdoviridae. Its G glycoprotein is responsible for receptor recognition, on the host cell surface, that triggers clathrin-mediated endocytosis of VSV. Then, within the acidic environment of the endosome, VSV G undergoes a fusogenic conformational change from the pre-fusion form of G to its post-fusion form, leading the fusion of both membranes. G is also the target of virus-neutralizing antibodies. Both structures of the pre- and post-fusion forms of the soluble ectodomain of G (i.e. without its transmembrane part) were determined by radiocrystallography. These structures established G as the prototype of class III fusion glycoproteins. However, the organization of the carboxyterminal part of the ectodomain and the transmembrane domain of G, which play an important role during the fusion process, remains unknown. Therefore, we carried out a cryo-electron microscopy study on the complete glycoprotein, directly purified from viral particles, alone or in complex with a monoclonal antibody. This study led to complete the structures of the ectodomain in its pre- and post-fusion conformations. It also revealed that the transmembrane domains are mobile within the membrane. We have also solved two structures of G in complex with a FAb derived from a neutralizing antibody, recognizing both pre- and post-fusion forms of G from several strains of Vesiculovirus. Based on these first structures of a complex between G and an antibody, we could characterize the epitope, identify the key G residues in the interaction and propose a neutralization mechanism. This work significantly increases our knowledge of the structure of G, which is the most widely used glycoprotein in biotechnology for cargo delivery and in gene therapy (by lentivirus pseudotyping).We also initiated a study aimed at characterizing the glycoproteins of Lyssaviruses, a genus also part of the Rhabdoviridae family, and for which rabies virus is the prototype. We produced and purified the ectodomains of several Lyssaviruses, and we were able to obtain a crystallographic structure of the ectodomain of Ikoma virus (IKOV G), which corresponds to a late monomeric intermediate. Several approaches are underway to further characterize this structure. We also carried out a phage display selection of alphaReps directed against IKOV G. Alphareps are artificial proteins binders consisting of helical repeats. 6 out of 11 alphareps are able to bind IKOVG. Complexes of IKOV G with alphareps are currently being characterized. We plan to i) use these tools as crystallization helpers to trap different conformations of G in crystallography or cryo-EM ii) evaluate the potential antiviral activity of these alphareps
Shandilya, Shivender. "Structural Studies of the Anti-HIV Human Protein APOBEC3G Catalytic Domain: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/562.
Texto completoLuque, Santolaria Antoni. "Structure, Mechanical Properties, and Self-Assembly of Viral Capsids". Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/31993.
Texto completoSoumana, Djade I. "Hepatitis C Virus: Structural Insights into Protease Inhibitor Efficacy and Drug Resistance: A Dissertation". eScholarship@UMMS, 2015. http://escholarship.umassmed.edu/gsbs_diss/803.
Texto completoKoopman, Tammy L. "Production of Porcine Single Chain Variable Fragment (SCFV) selected against a recombinant fragment of Porcine Reproductive and Respiratory Syndrome virus non structural protein 2". Thesis, Kansas State University, 2011. http://hdl.handle.net/2097/13189.
Texto completoDepartment of Diagnostic Medicine/Pathobiology
Richard 'Dick' Hesse
Carol Wyatt
Over the last two decades molecular laboratory techniques have enabled researchers to investigate the infection, replication and pathogenesis of viral disease. In the early eighties, Dr. George Smith developed a unique system of molecular selection. He showed that the fd bacteriophage genome could be manipulated to carry a sequence of DNA coding for a protein not contained in the phage genome. Infection of the recombinant bacteriophage or phagemid into a specific strain of the bacterium, Escherichia coli, produced progeny phage with the coded protein displayed as a fusion with the phage's coat protein. Antibody phage display utilizes the same technology with the DNA encoding an antibody fragment. The DNA insert can carry the information to produce either a single chain variable fragment (scFv) producing the heavy chain variable and light chain variable (VH-VL) portion or a Fab fragment which also contains the heavy chain constant 1 with the light chain constant (CH and CL) portion of an antibody. Screening an antibody phage display library has the possibility of producing an antibody not produced in the normal course of immune selection. This decade also saw the emergence of a viral disease affecting the porcine population. The Porcine Reproductive and Respiratory Syndrome virus (PRRSV) has been one of the most costly diseases affecting the pig producer. Molecular investigations found that PRRSV is a single, positive-stranded RNA virus which codes for five structural and 12-13 nonstructural proteins producing an enveloped, icosahedral virus. An interesting characteristic of PRRSV is the ability to produce infective progeny with genomic deletions, insertions and mutations within the nonstructural protein 2 (nsp2). With this knowledge, many researchers have produced marker vaccines containing fluorescent tags with the hope of developing a DIVA (Differentiate Infected from Vaccinated Animals) vaccine. In my Master‟s studies, I studied the techniques of antibody phage display technology and how to apply these methods to producing scFvs which recognize a recombinant PRRSV nsp2 fragment protein and the native protein during infection of MARC-145 cells.
Arista, Romero Maria. "Unveiling viral structures by single-molecule localization microscopy". Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/672262.
Texto completoWall, Erin A. "ELUCIDATION OF A NOVEL PATHWAY IN STAPHYLOCOCCUS AUREUS: THE ESSENTIAL SITE-SPECIFIC PROCESSING OF RIBOSOMAL PROTEIN L27". VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3747.
Texto completoDhar, Jayeeta. "Suppression of Pulmonary Innate Immunity by Pneumoviruses". Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1479673989904175.
Texto completoBenachenhou, Farid. "Retroviral long Terminal Repeats; Structure, Detection and Phylogeny". Doctoral thesis, Uppsala universitet, Klinisk virologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120028.
Texto completoCoutard, Bruno. "Contribution de la biotechnologie à la virologie structurale et fonctionnelle". Aix-Marseille 2, 2007. http://theses.univ-amu.fr.lama.univ-amu.fr/2007AIX22046.pdf.
Texto completoOzen, Aysegul. "Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation". eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/677.
Texto completoOzen, Aysegul. "Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation". eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/677.
Texto completoFeng, Yuqin. "Molecular epidemiological analysis of rabies viruses associated with population structure of bat hosts". Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27243.
Texto completoRoznowski, Aaron. "A Structure-Function Analysis of the phiX174 DNA Piloting Protein". Thesis, The University of Arizona, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13812936.
Texto completoIn order to initiate an infection, bacteriophages must deliver their large, hydrophilic genomes across their host’s hydrophobic cell wall. Bacteriophage ϕX174 accomplishes this task with a set of identical DNA piloting proteins. The structure of the piloting protein’s central domain was solved to 2.4 Å resolution. In it, ten proteins are oligomerized into an α-helical barrel, or tube, that is long enough to span the host’s cell wall and wide enough for the circular, ssDNA to pass through. This structure was used as a guide to explore the mechanics of ϕX174 genome delivery. In the first study, the H-tube’s highly repetitive primary and quaternary structure made it amenable to a genetic analysis using in-frame insertions and deletions. Length-altered proteins were characterized for the ability to perform the protein’s three known functions: participation in particle assembly, genome translocation, and stimulation of viral protein synthesis.
The tube’s inner surface was altered in the second study. The surface is primarily lined with amide and guanidinium containing amino acid side chains with the exception of four sites near the tube’s C-terminal end. The four sites are conserved across microvirus clades, suggesting that they may play an important role during genome delivery. To test this hypothesis and explore the general role of the amide and guanidinium containing side chains, the amino acids at these sites were changed to glutamine. The resulting mutants had a cold-sensitive phenotype at 22 °C. Viral lifecycle steps were assayed in order to determine which step was disrupted by the mutant glutamine residues. The results support a model in which a balance of forces governs genome delivery: potential energy provided by the densely packaged viral genome and/or an osmotic gradient push the genome into the cell, while the tube’s inward facing residues exert a frictional force on the genome as it passes.
Bacteriophage must first identify a susceptible host prior to genome delivery. In the final study, biochemical and genetic analyses were conducted with two closely related bacteriophages, α3 and ST-1. Despite ~90% amino acid identity, the natural host of α3 is Escherichia coli C, whereas ST-1 is a K-12-specific phage. To determine which structural proteins conferred host range specificity, chimeric virions were generated by individually interchanging the coat, spike, or DNA pilot proteins. Interchanging the coat protein switched host range. However, host range expansion could be conferred by single point mutations in the coat protein. The expansion phenotype was recessive: mutant progeny from co-infected cells did not display the phenotype. Novel virus propagation and selection protocols were developed to isolate host range expansion mutants. The resulting genetic and structural data were consistent enough that host range expansion could be predicted, broadening the classical definition of antireceptors to include interfaces between protein complexes within the capsid.
O'Hara, Maureen. "Relating the structure of the HSV-1 UL25 DNA packaging protein to its function". Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/1326/.
Texto completoRomano, Keith P. "Mechanisms of Substrate Recognition by HCV NS3/4A Protease Provide Insights Into Drug Resistance: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/554.
Texto completoFan, Wan Ho. "Investigating the structure of herpes simplex virus - 1 at the interface between the capsid and tegument". Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6876/.
Texto completoCoulibaly, Fasséli. "Etude structurale des birnavirus : identification des déterminants d'antigénicité, de virulence et d'assemblage : mise en évidence d'un lien évolutif entre virus à ARN(+) et à ARN double brin". Paris 11, 2003. http://www.theses.fr/2003PA112236.
Texto completoBirnaviruses appear to be atypical among icosahedral RNA viruses. Their genomic and structural organization lead to comparisons with members of the Reoviridae family. However, birnaviruses seem to bear more functional similarities to positive-strand RNA viruses such as Nodaviridae or Picornaviridae. We have determined the structures of T=l icosahedral subviral particles of two birnaviruses. Twenty copies of the attachment protein VP2 trimers make up these 260A-wide particles. VP2 folds as two orthogonal jelly rolls on top of a helical domain. The radial jelly roll is the trimeric spike (domain P) projecting outward of a continuous icosahedral shell formed by the other jelly roll (domain S). Domain P is the major site of virus-host interactions as it bears all the neutralizing epitopes as well as the determinants of viral tropism and virulence. Helical domain B coats the inner surface of the particle providing a domain of interaction to other viral constituents such as RNA or VP3. In particular, this domain forms a helical barrel at five fold axes which might be involved in viral RNA exit. Our structural comparison of VP2 structure to other capsid proteins points to an evolutionary link between RNA(+) (Nodaviridae and Tetraviridae) and double-stranded RNA (Reoviridae) viruses embodied by Birnaviruses. Finally, a fit of VP2 in the viral particle requires a major conformational change. We propose a model for morphogenesis in which VP3 binding to VP2 would act as a molecular switch triggering assembly thereafter driven by VP2 self association capacities
DORE, PETIT-MAIRE ISABELLE. "Utilisation des anticorps monoclonaux en virologie vegetale : diagnostic et etudes structurales de quelques tobamovirus". Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13097.
Texto completoDore, Isabelle. "Utilisation des anticorps monoclonaux en virologie végétale diagnostic et études structurales de quelques tobamovirus /". Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37604651w.
Texto completoHornsey, Crystal A. "The function of extensive structured RNA in the evasion of host anti-virus responses". Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/56672/.
Texto completoMittal, Seema. "Role of Protein Flexibility in Function, Resistance Pathways and Substrate Recognition Specificity in HIV-1 Protease: A Dissertation". eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/573.
Texto completoEno-Ibanga, Cheryl K. "The analysis of a conserved RNA structure in the 3D polymerase encoding region of human parechovirus 1". Thesis, University of Essex, 2016. http://repository.essex.ac.uk/19097/.
Texto completoLin, Kuan-Hung. "Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation". eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/841.
Texto completo