Bibliografías temáticas / Stem cells

Literatura académica sobre el tema "Stem cells"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 7 de julio de 2024

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Artículos de revistas sobre el tema "Stem cells"

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CR, Thambidorai. "Stem Cells in Urethral Replacement". Journal of Embryology & Stem Cell Research 4, n.º 1 (2020): 1–2. http://dx.doi.org/10.23880/jes-16000139.

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Aguilar-Gallardo, Cristóbal y Carlos Simón. "Cells, Stem Cells, and Cancer Stem Cells". Seminars in Reproductive Medicine 31, n.º 01 (17 de enero de 2013): 005–13. http://dx.doi.org/10.1055/s-0032-1331792.

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Srivastava, A. N., Neema Tiwari, Shailendra Yadav y Suryakant . "LUNG CANCER STEM CELLS-AN UPDATE". Era's journal of medical research 4, n.º 1 (1 de junio de 2017): 22–31. http://dx.doi.org/10.24041/ejmr2017.4.

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Yang, Junzheng. "Stem Cells Applications in Neurodegenerative Diseases". Epidemiology International Journal 7, n.º 4 (2023): 1–6. http://dx.doi.org/10.23880/eij-16000267.

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Neurodegenerative diseases are a kind of diseases caused by progressive loss of neuronal structure and function and glial cell homeostasis imbalance, there are many kinds of neurodegenerative diseases include Alzheimer's disease (AD), Parkinson's disease (PD); Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). So far, due to the lack of ideal treatment methods, it seriously threats to human health especially the elder population. Recently, with the rapid development of regenerative medicine, stem cells rely on their advantages including self-renewing capability, low immunogenicity, migration and homing capabilities, and stem cell derivatives including stem cells derived extracellular vesicles and stem cell-derived organoids, it provides unlimited application possibilities for the treatment of neurodegenerative diseases. In this review, we will summarize the recent research progress on the preclinical and clinical applications of stem cells in neurodegenerative diseases, hope that the reviews may provide some useful clues for researchers.
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Weigel, Detlef y Gerd Jürgens. "Stem cells that make stems". Nature 415, n.º 6873 (febrero de 2002): 751–54. http://dx.doi.org/10.1038/415751a.

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J, Otsuka. "A Theoretical Study on the Cell Differentiation Forming Stem Cells in Higher Animals". Physical Science & Biophysics Journal 5, n.º 2 (2021): 1–10. http://dx.doi.org/10.23880/psbj-16000191.

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The recent genome sequencing of multicellular diploid eukaryotes reveals an enlarged repertoire of protein genes for signal transmission but it is still difficult to elucidate the network of signal transmission to drive the life cycle of such an eukaryote only from biochemical and genetic studies. In the present paper, a theoretical study is carried out for the cell differentiation, the formation of stem cells and the growth from a child to the adult in the higher animal. With the intercellular and intracellular signal transmission in mind, the cell differentiation is theoretically derived from the process by the transition of proliferated cells from proliferation mode to differentiation mode and by both the long-range interaction between distinctive types of cells and the short-range interaction between the same types of cells. As the hierarchy of cell differentiation is advanced, the original types of self-reproducible cells are replaced by the self-reproducible cells returned from the cells differentiated already. The latter type of self-reproducible cells are marked with the signal specific to the preceding differentiation and become the stem cells for the next stage of cell differentiation. This situation is realized under the condition that the differentiation of cells occurs immediately after their proliferation in the development. The presence of stem cells in the respective lineages of differentiated cells strongly suggests another signal transmission for the growth of a child to a definite size of adult that the proliferation of stem cells in one lineage is activated by the signal from the differentiated cells in the other lineage(s) and is suppressed by the signal from the differentiated cells in its own lineage. This style of signal transmission also explains the metamorphosis and maturation of germ cells in higher animals.
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Challa, Stalin Reddy y Swathi Goli. "Differentiation of Human Embryonic Stem Cells into Engrafting Myogenic Precursor Cells". Stem cell Research and Therapeutics International 1, n.º 1 (16 de abril de 2019): 01–05. http://dx.doi.org/10.31579/2643-1912/002.

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Degenerative muscle diseases affect muscle tissue integrity and function. Human embryonic stem cells (hESC) are an attractive source of cells to use in regenerative therapies due to their unlimited capacity to divide and ability to specialize into a wide variety of cell types. A practical way to derive therapeutic myogenic stem cells from hESC is lacking. In this study, we demonstrate the development of two serum-free conditions to direct the differentiation of hESC towards a myogenic precursor state. Using TGFß and PI3Kinase inhibitors in combination with bFGF we showed that one week of differentiation is sufficient for hESC to specialize into PAX3+/PAX7+ myogenic precursor cells. These cells also possess the capacity to further differentiate in vitro into more specialized myogenic cells that express MYOD, Myogenin, Desmin and MYHC, and showed engraftment in vivo upon transplantation in immunodeficient mice. Ex vivo myomechanical studies of dystrophic mouse hindlimb muscle showed functional improvement one month post-transplantation. In summary, this study describes a promising system to derive engrafting muscle precursor cells solely using chemical substances in serum-free conditions and without genetic manipulation.
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Nighojkar, Urvashi Rajeev, Dr Priya A. Lele y Mudita Agrawal. "Scope of Stem Cells in Periodontal Regeneration". International Journal of Scientific Research 2, n.º 5 (1 de junio de 2012): 428–31. http://dx.doi.org/10.15373/22778179/may2013/145.

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P, Pradeep. "Role of Stem Cells in Cerebral Infarction". Journal of Embryology & Stem Cell Research 2, n.º 2 (2018): 1–8. http://dx.doi.org/10.23880/jes-16000112.

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Karunanithi Arulvizhi M, Arunagiri. "Stem Cells in Periodontal Regenerations - A Review". International Journal of Science and Research (IJSR) 13, n.º 2 (5 de febrero de 2024): 589–94. http://dx.doi.org/10.21275/sr24206105401.

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Tesis sobre el tema "Stem cells"

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Falk, Anna. "Stem cells : proliferation, differentiation, migration /". Stockholm, 2005. http://diss.kib.ki.se/2006/91-7140-497-X/.

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Meletis, Konstantinos. "Studies on adult stem cells /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-803-7/.

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Harun, Rosliah. "Derivation of trophoblast stem cells from human embryonic stem cells". Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414643.

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Gilner, Jennifer Bushman Kirby Suzanne Lee. "Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1232.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.
Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology and Laboratory Medicine." Discipline: Pathology and Laboratory Medicine; Department/School: Medicine.
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Marshall, Gregory Paul. "Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells /". [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.
Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.
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Eriksson, Malin. "Manipulating neural stem cells". Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-853-2/.

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Gupta, Gunjan. "Effect of chondrocyte-stem cell interactions on chondrogenesis of mesenchymal stem cells". Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1465607.

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Thesis (M.S.)--University of California, San Diego, 2009.
Title from first page of PDF file (viewed August 11, 2009). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 128-134).
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Noisa, Parinya. "Characterization of neural progenitor/stem cells derived from human embryonic stem cells". Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes. It was found that neural differentiation of hESCs could be divided into 5 stages according to their morphology, marker expression and differentiation potencies: hESCs, neural initiation, neural epithelium/rosette, neuronal progenitor cells and neural progenitor/stem cells (NPSCs) and 4 of these stages have been studied in more detail. At the neural initiation, hESCs firstly lose TRA-1-81 expression but retain SSEA4 expression. This transient cell population shows several similar properties to the primitive ectoderm. After neural-tube like structure/neural rosette formation, neural progenitor cells appear as typical bipolar structures and exhibit several properties of radial glial cells, including gene expression and pro-neuronal differentiation. The neural progenitor cells are able to grow in culture for a long time in the presence of growth factors bFGF and EGF. However, they gradually lose their bipolar morphology to triangular cell type and become pro-glial upon further differentiation. In addition, the state of neural progenitor and stem cells can be distinguished by their differential response to canonical Notch effector, C protein-binding factor 1. It was also found that delta like1 homolog (DLK-1) is temporally upregulated upon initial neural differentiation, but becomes undetectable after the neural progenitor stage. Overexpression of DLK-1 in NPSCs enhances neuronal differentiation in the presence of serum by blocking BMP and Notch pathways. These results show that neural differentiation of hESCs is a dynamic process in which cells go through sequential changes, and the events are reminiscent of the in vivo neurodevelopment process. Moreover, I have characterized stably transfected nestin-GFP reporter hESC lines and found that the cell lines maintained the features of hESCs and the expression of GFP is restricted to the neural lineage after differentiation. Therefore, these reporter lines will be useful for the study of factors that regulate neural differentiation and for the enrichment of neural progenitors from other lineages. Taken together, this study has demonstrated that hESCs are a good in vitro model to study the mechanisms and pathways that are involved in neural differentiation. The availability of hESCs allows us to explore previously inaccessible processes that occur during human embryogenesis, such as gastrulation and neurogenesis.
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Beaver, C. M. "Clonogenicity and stem cells". Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1400299/.

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Primary keratinocytes form 3 types of colony with different morphologies termed holoclones, meroclones and paraclones, thought to be derived from stem, early and late stage precursor cells respectively (Barrandon and Green, 1987b, Rochat et al., 1994). Cancer cell lines produce colonies with morphologies analogous to those of holoclones, meroclones and paraclones, and consequently holoclone morphology is used as a surrogate marker for stem cell colonies. The aim of this study was to elucidate the relationship between clonogenicity, colony morphology and stem cells. Colonies formed by primary prostate epithelial cells and prostate cancer cell lines (DU145, PC3, LNCaP) were characterised. The proportions of colonies were not altered significantly by modification of culture conditions. In contrast to cancer cells, primary prostate epithelial cells form only two types of colony, termed types 1 and 2, which are analogous to holoclones and paraclones. Only type 1 colonies were highly proliferative, able to self-renew and express putative stem cell markers. Paradoxically, cells from DU145 meroclones formed holoclones and had self-renewal capacity (by serial cloning and xenografting). It is concluded that the major difference between holoclone and meroclone colonies from the cancer cell line DU145 is the proportion of stem cells within each colony, not the presence or absence of stem cells. Phage display was used to look for targets on the surface of cells in Type 1 colonies. Various experimental protocols were tested, but no targets were identified.
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Luís, Ana Isabel Lopes. "Stem cells and Stroke". Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/50130.

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Libros sobre el tema "Stem cells"

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Irina, Klimanskaya y Lanza Robert, eds. Adult stem cells. Amsterdam: Elsevier Academic Press, 2006.

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W, Masters J. R., Palsson Bernhard y Thomson James A. Dr, eds. Embryonic stem cells. Dordrecht: Springer, 2007.

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W, Rosales Derek y Mullen Quentin N, eds. Pluripotent stem cells. Hauppauge, N.Y: Nova Science Publishers, 2009.

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Kursad, Turksen, ed. Adult stem cells. Totowa, N.J: Humana Press, 2004.

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Jacqueline, Langwith, ed. Stem cells. Detroit: Greenhaven Press, 2007.

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Stem cells. Detroit: Greenhaven Press, 2012.

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Stem cells. New York: Nova Science Publishers, 2009.

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Chowdhury, Suchandra y Shyamasree Ghosh. Stem Cells. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-1638-9.

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Haider, Khawaja H., ed. Stem Cells. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77052-5.

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Wobus, Anna M. y Kenneth R. Boheler, eds. Stem Cells. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-31265-x.

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Capítulos de libros sobre el tema "Stem cells"

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Van Pham, Phuc. "Stem Cells and Cancer Stem Cells". En SpringerBriefs in Stem Cells, 5–24. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-22020-8_2.

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Deb, Arjun. "Stem Cells". En Atherosclerosis, 173–86. Hoboken, NJ: John Wiley & Sons, Inc, 2015. http://dx.doi.org/10.1002/9781118828533.ch14.

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Müller, Benedikt y Suzanne Kadereit. "Stem Cells". En Drug Discovery and Evaluation: Pharmacological Assays, 4201–19. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-05392-9_114.

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Kumano, Keiki. "Stem Cells". En Encyclopedia of Behavioral Medicine, 2137–38. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_429.

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Kumano, Keiki. "Stem Cells". En Encyclopedia of Behavioral Medicine, 1879. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_429.

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Zaman, Nadia N. y Dayna McCarthy. "Stem Cells". En Regenerative Medicine for Spine and Joint Pain, 43–53. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42771-9_4.

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Trebinjac, Suad y Manoj Kumar Nair. "Stem Cells". En Regenerative Injections in Sports Medicine, 93–103. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-6783-4_11.

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Handral, Harish K., Gopu Sriram y Tong Cao. "Stem Cells". En Stem Cells in Toxicology and Medicine, 26–49. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781119135449.ch3.

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Lynch, Gordon S., David G. Harrison, Hanjoong Jo, Charles Searles, Philippe Connes, Christopher E. Kline, C. Castagna et al. "Stem Cells". En Encyclopedia of Exercise Medicine in Health and Disease, 810–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_181.

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Heppner, John B., David B. Richman, Steven E. Naranjo, Dale Habeck, Christopher Asaro, Jean-Luc Boevé, Johann Baumgärtner et al. "Stem Cells". En Encyclopedia of Entomology, 3540. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6359-6_4373.

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Actas de conferencias sobre el tema "Stem cells"

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Smith, Alan. "Stem cells". En SIGGRAPH '20: Special Interest Group on Computer Graphics and Interactive Techniques Conference. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3368827.3389225.

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Wahl, GM. "BS1-1: Stem Cells, Cancer, and Cancer Stem Cells." En Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-bs1-1.

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Hay, David. "Building Implantable Human Liver Tissue from Pluripotent Stem Cells". En Cells 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021016.

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Singh, Ankur, Shalu Suri, Ted T. Lee, Jamie M. Chilton, Steve L. Stice, Hang Lu, Todd C. McDevitt y Andrés J. Garcia. "Adhesive Signature-Based, Label-Free Isolation of Human Pluripotent Stem Cells". En ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80044.

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Generation of human induced pluripotent stem cells (hiPSCs) from fibroblasts and other somatic cells represents a highly promising strategy to produce auto- and allo-genic cell sources for therapeutic approaches as well as novel models of human development and disease1. Reprogramming protocols involve transduction of the Yamanaka factors Oct3/4, Sox2, Klf4, and c-Myc into the parental somatic cells, followed by culturing the transduced cells on mouse embryonic fibroblast (MEF) or human fibroblast feeder layers, and subsequent mechanical dissociation of pluripotent cell-like colonies for propagation on feeder layers1, 2. The presence of residual parental and feeder-layer cells introduces experimental variability, pathogenic contamination, and promotes immunogenicity3. Similar to human embryonic stem cells (hESCs), reprogrammed hiPSCs suffer from the unavoidable problem of spontaneous differentiation due to sub-optimal feeder cultures4, growth factors5, and the feeder-free substrate6. Spontaneously differentiated (SD)-hiPSCs display reduced pluripotency and often contaminate hiPSC cultures, resulting in overgrowth of cultures and compromising the quality of residual pluripotent stem cells5. Therefore, the ability to rapidly and efficiently isolate undifferentiated hiPSCs from the parental somatic cells, feeder-layer cells, and spontaneously differentiated cells is a crucial step that remains a bottleneck in all human pluripotent stem cell research.
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Ahsan, Taby, Adele M. Doyle, Garry P. Duffy, Frank Barry y Robert M. Nerem. "Stem Cells and Vascular Regenerative Medicine". En ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-193591.

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Vascular applications in regenerative medicine include blood vessel substitutes and vasculogenesis in ischemic or engineered tissues. For these repair processes to be successful, there is a need for a stable supply of endothelial and smooth muscle cells. For blood vessel substitutes, the immediate goal is to enable blood flow, but vasoactivity is necessary for long term success. In engineered vessels, it is thought that endothelial cells will serve as an anti-thrombogenic lumenal layer, while smooth muscle cells contribute to vessel contractility. In other clinical applications, what is needed is not a vessel substitute but the promotion of new vessel formation (vasculogenesis). A simplified account of vasculogenesis is that endothelial cells assemble to form vessel-like structures that can then be stabilized by smooth muscle cells. Overall, the need for new vasculature to transfer oxygen and nutrients is important to reperfuse not only ischemic tissue in vivo, but also dense, structurally complex engineered tissue. The impact of these vascular therapies, however, is limited in part by the low yield and inadequate in vitro proliferation potential of primary endothelial and smooth muscle cells. Thus, there is a need to address the cell sourcing issue for vascular cell-based therapies, potentially using stem cells.
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Shu, K., H. Thatte y M. Spector. "Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells". En 2009 IEEE 35th Annual Northeast Bioengineering Conference. IEEE, 2009. http://dx.doi.org/10.1109/nebc.2009.4967739.

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Gil, Chang-Hyun, Dibyendu Chakraborty, Cristiano P. Vieira, Nutan Prasain, Sergio Li Calzi, Seth D. Fortmann, Ping Hu et al. "Human Pluripotent Stem Cells from Diabetic and Nondiabetics Improve Retinal Pathology in Diabetic Mice". En Cells 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021033.

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Lobba, Aline RM, Maria Fernanda PAD Forni, Carolina Perozzi, Ana Claúdia O. Carreira, Leticia Labriola y Mari Cleide Sogayar. "Abstract 3872: Differentially expressed stem cell markers in breast cancer stem cells". En Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3872.

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Saito, Norihiko, Nozomi Hirai, Kazuya Aoki, Satoshi Fujita, Haruo Nakayama, Morito Hayashi, Takatoshi Sakurai y Satoshi Iwabuchi. "Abstract 2621: OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells". En Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2621.

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Saito, Norihiko, Nozomi Hirai, Kazuya Aoki, Satoshi Fujita, Haruo Nakayama, Morito Hayashi, Takatoshi Sakurai y Satoshi Iwabuchi. "Abstract 2621: OLIG2 regulates stem cell maintenance and cell cycle in glioma stem cells". En Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2621.

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Informes sobre el tema "Stem cells"

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Risbridger, Gail P. Stem Cells in Prostate. Fort Belvoir, VA: Defense Technical Information Center, marzo de 2006. http://dx.doi.org/10.21236/ada456262.

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Jones, Richard. Ovarian Carcinoma Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, mayo de 2009. http://dx.doi.org/10.21236/ada508216.

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Gupta, Shweta. Can Stem Cells Reverse Aging? Science Repository, febrero de 2021. http://dx.doi.org/10.31487/sr.blog.27.

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Stem cells act as body’s repair system by replacing and rejuvenating aging cells for the maintenance of health. With the current existing information on stem cells, it is actually attainable to delay aging and improve both health and life expectancy.
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Levine, Charles. Sonic Hedgehog Signaling in Normal Prostate Stem Cells and Prostate Cancer Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, enero de 2008. http://dx.doi.org/10.21236/ada488414.

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Levine, Charles. Sonic Hedgehog Signaling in Normal Prostate Stem Cells And Prostate Cancer Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, enero de 2009. http://dx.doi.org/10.21236/ada545298.

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Jones, Richard. Targeting Ovarian Carcinoma Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, mayo de 2012. http://dx.doi.org/10.21236/ada581693.

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Donohue, Henry J., Christopher Niyibizi y Alayna Loiselle. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Fort Belvoir, VA: Defense Technical Information Center, septiembre de 2013. http://dx.doi.org/10.21236/ada606237.

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Donahue, Henry J. Induced Pluripotent Stem Cell Derived Mesenchymal Stem Cells for Attenuating Age-Related Bone Loss. Fort Belvoir, VA: Defense Technical Information Center, julio de 2012. http://dx.doi.org/10.21236/ada581680.

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Signoretti, Sabina. The Basal Cell Marker p63 and Prostate Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, mayo de 2002. http://dx.doi.org/10.21236/ada406963.

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Signoretti, Sabina. The Basal Cell Marker p63 and Prostate Stem Cells. Fort Belvoir, VA: Defense Technical Information Center, mayo de 2004. http://dx.doi.org/10.21236/ada427706.

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