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Mark, Brady, Jaxon Dawson y Dominic Chase. "The Management of Actinic Keratosis and Squamous Cell Carcinoma". Dermatology and Dermatitis 2, n.º 1 (26 de febrero de 2018): 01–03. http://dx.doi.org/10.31579/2578-8949/019.
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Background: Actinic keratosis or solar keratosis is a common skin lesion caused by sun damage that progresses to squamous cell carcinoma. It has been suggested that actinic keratosis is in fact SCC in situ. Objective: This literature review was conducted to investigate the differences between actinic keratosis and squamous cell carcinoma and whether actinic keratosis should in fact be managed as squamous cell carcinoma. Methods: A literature review was conducted to assess the differences between actinic keratosis and squamous cell carcinoma. We conducted searches of Pubmed, Cochrane and Medline for articles published between January 1, 2000 and April 30, 2014, using the following search terms: actinic keratosis, solar keratosis, skin cancer, squamous cell carcinoma, dermoscopy, sun exposure, ultra violet radiation, and dysplasia. Studies published in English were selected for inclusion in this review as were additional articles identified from bibliographies. Results: It is difficult to distinguish between both actinic keratosis and squamous cell carcinoma. Perhaps a classification system for actinic keratosis including early in situ SCC type AK1, early in situ SCC type AK2 and in situ SCC type actinic keratosis is needed. Conclusion: Actinic keratosis invades the basement membrane and as such may progress into invasive SCC. Superficially actinic keratoses are not distinguishable from a superficial SCC and as such may go unrecognized or inaccurately diagnosed.
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Chung, Hye Jin, Kelly L. McGuigan, Katie L. Osley, Kate Zendell y Jason B. Lee. "Pigmented solar (actinic) keratosis: An underrecognized collision lesion". Journal of the American Academy of Dermatology 68, n.º 4 (abril de 2013): 647–53. http://dx.doi.org/10.1016/j.jaad.2012.10.050.
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Misago, Noriyuki, Tatsurou Tanaka y Hiromu Kohda. "Trichilemmal Carcinoma Occurring in a Lesion of Solar Keratosis". Journal of Dermatology 20, n.º 6 (junio de 1993): 358–64. http://dx.doi.org/10.1111/j.1346-8138.1993.tb01298.x.
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Adil, Dehhaze, Ahmar-Rass Nour El Imane, Diher Issam, Taybi Othmane, Labbaci Rim y Daghouri Nada-Imane. "ANATOMOCLINICAL CONFRONTATION BETWEEN MELANOMA, SOLAR LENTIGO AND SEBORRHEIC KERATOSIS: A CASE REPORT". International Journal of Advanced Research 9, n.º 10 (31 de octubre de 2021): 728–31. http://dx.doi.org/10.21474/ijar01/13603.
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The primary diagnosis in case of a rapidly developing facipigmented lesion in an elderly patient is Dubreuilhs melanoma . This case report is highlighting the issue of anatomoclinical confrontation between a clinically suspected melanoma and a pathologically confirmed solar lentigo and seborrheic keratosis.
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Bujnauskajte, E., S. Rubins, A. Rubins, Y. Makstiene y Y. Bujnauskiene. "Can the lesions induced with actinic keratosis become an enigma for dermatologists? Results of an open perspective study". Vestnik dermatologii i venerologii 93, n.º 2 (24 de abril de 2017): 53–59. http://dx.doi.org/10.25208/0042-4609-2017-93-2-53-59.
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Different face skin diseases (basal cell carcinoma, actinic keratosis, rosacea, solar elastosis, etc.) could clinically manifest itself as erythematic patches, pimples or plagues. It is very hard to make the clinical exclusion in some cases of these diseases since their characters can partially overlap or certain lesion can mimic another one especially in the cases of skin areas affected with sun. Therefore, the histopathological analysis remains the “golden standard” of the dermatological diagnosis at skin diseases. Our study has shown that certified dermatologists detect actinic keratosis (AK) of face/head skin of I/II levels very well. Verdicts of dermatologists and pathomorfologists are congruent on account of diagnosis in 90,7% cases. Diseases clinically excluded as AK revealed as malignant neoplasms (basal cell carcinoma) in less than 1% of case lesions.
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Karkuzhali, Ponnuswamy, Nellainayagam Gomathy y ParveenBashir Ahamed. "Sebaceous carcinoma of cheek arising in a lesion of solar keratosis". Indian Journal of Dermatology 54, n.º 5 (2009): 16. http://dx.doi.org/10.4103/0019-5154.45434.
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Almuayqil, Saleh Naif, Sameh Abd El-Ghany y Mohammed Elmogy. "Computer-Aided Diagnosis for Early Signs of Skin Diseases Using Multi Types Feature Fusion Based on a Hybrid Deep Learning Model". Electronics 11, n.º 23 (2 de diciembre de 2022): 4009. http://dx.doi.org/10.3390/electronics11234009.
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According to medical reports and statistics, skin diseases have millions of victims worldwide. These diseases might affect the health and life of patients and increase the costs of healthcare services. Delays in diagnosing such diseases make it difficult to overcome the consequences of these types of disease. Usually, diagnosis is performed using dermoscopic images, where specialists utilize certain measures to produce the results. This approach to diagnosis faces multiple disadvantages, such as overlapping infectious and inflammatory skin diseases and high levels of visual diversity, obstructing accurate diagnosis. Therefore, this article uses medical image analysis and artificial intelligence to present an automatic diagnosis system of different skin lesion categories using dermoscopic images. The addressed diseases are actinic keratoses (solar keratoses), benign keratosis (BKL), melanocytic nevi (NV), basal cell carcinoma (BCC), dermatofibroma (DF), melanoma (MEL), and vascular skin lesions (VASC). The proposed system consists of four main steps: (i) preprocessing the input raw image data and metadata; (ii) feature extraction using six pre-trained deep learning models (i.e., VGG19, InceptionV3, ResNet50, DenseNet201, and Xception); (iii) features concatenation; and (iv) classification/diagnosis using machine learning techniques. The evaluation results showed an average accuracy, sensitivity, specificity, precision, and disc similarity coefficient (DSC) of around 99.94%, 91.48%, 98.82%, 97.01%, and 94.00%, respectively.
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Gimeno-Carrero, Mónica, María-Jesús Suárez-Fernández, Beatriz Alonso-Martín, Almudena de-Pablo-Cabrera, María-Concepción Garrido-Ruíz y Enrique Mencía-Gutiérrez. "Conjunctival Tarsal Actinic Keratosis Treated with Interferon Alfa-2b: A Rare Case Report and Literature Review". Case Reports in Ophthalmological Medicine 2021 (22 de enero de 2021): 1–5. http://dx.doi.org/10.1155/2021/6616021.
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Conjunctival neoplasia is one of the most frequent tumors in the eye. Actinic keratosis (AK) or solar keratosis is a precancerous lesion that is included with other epithelial tumors. This alteration does not break the basal membrane. There is enough evidence of successful outcomes to consider interferon alfa-2b (IFN alfa-2b) as the first choice of treatment for this type of tumors. In addition, side effects are mild and uncommon. We report a case in an 83-year-old woman who was referred to evaluate a leukoplakia in the tarsal conjunctiva of the lower left eyelid that measured 1 cm in diameter. Pathological study revealed AK. After the INF alfa-2b treatment, we observed conjunctival hyperemia, noninfiltrated upper nasal de-epithelization, and inferior nasal bulla. AK with presentation in conjunctiva is rarely described and in tarsal conjunctiva is exceptional. It is the first case published with only tarsal conjunctiva affectation.
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Snarskaya, Elena S., Zhaber Mukhamed Awad y L. M. Shnahova. "COMBINED PHOTOINDUCED PATHOLOGY OF THE SKIN AND EYES IN PATIENTS WITH DERMATOHELIOSIS". Russian Journal of Skin and Venereal Diseases 22, n.º 1-2 (15 de abril de 2019): 4–10. http://dx.doi.org/10.17816/dv42929.
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Modern information on the mechanisms of the damaging effect of UV radiation on the skin and the eye is presented, constitutional phototype skin (according to the Fitzpatrick scale) and clinical stages of skin photoaging are described (according to R. Glogau). The range of clinical changes arising on the background of solar elastosis can vary depending on the anatomical site of the lesion and include a number of dermatoses included in the concept of solar elastosis syndromes, resulting in the development of malignant dermatoses. Depending on the type of UV exposure - sporadic short-term or systematic long-term, acute and chronic pathological processes caused by the action of UV may develop. The development of eyelid neoplasms (basal cell, metatypical, squamous cell carcinoma, melanoma), solar keratosis of the conjunctiva, pterygium, cataract, and macular retinal degeneration may result from the systematic UV irradiation of the organs of vision.
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Bhargava, Shashank, Ujjwal Kumar y Richa Rokde. "Premalignant and malignant changes of skin in a patient with oculocutaneous albinism: multiple actinic keratosis and squamous cell carcinoma". International Journal of Scientific Reports 4, n.º 2 (29 de enero de 2018): 40. http://dx.doi.org/10.18203/issn.2454-2156.intjscirep20180397.
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<p class="abstract"><span lang="EN-IN">Pigmentation of skin is a feature which is governed by multiple factors including the number of melanocytes, their metabolic activity of the melanocytes, the melanogenic activity of the melanosomes and lastly the morphology and differentiation of the melanosomes “Squamous cell carcinoma” (SCC) of sun-exposed skin is the most frequently observed malignancy among Albinos. It is ultimately due to lack of Eumelanin which guards against both the sunlight as well as oxidative stress-induced DNA damage. A 41 year old albino male patient presented with multiple asymptomatic raised skin lesions of different morphology and dimensions over scalp, neck, behind right ear and back with duration of 7 years. The initial lesion developed as a small papule over scalp which gradually progressed to present size and later appeared before the right ear, neck and lastly over the back. On examination, the initial lesion over scalp was verrucous plaque with adherent crusting, while other lesions were indurated, non-tender ulcers with irregular margins and punched out edges. There are few whitish raised scaly papules and plaques over the back. Routine investigations were within normal limits. Histopathology findings from the neck revealed squamous epithelium with tumour cells infiltrating the underlying stroma. Tumour cells showed pleomorphism, increased N:C ratio, hyperchromatic nuclei, prominent nucleoli and keratin pearls. Histopathology findings from the scaly lesion over the back revealed mild hyperkeratosis with dysplasia of the basal keratinocytes and prominent solar elastosis in the superficial dermis. Based on clinical and histopathogical findings, diagnosis of multiple SCC with actinic keratosis was made. Patient was referred to oncosurgeon for further management. Early detection and prompt treatment of the disease is required to reduce the spread to other parts of the body along with photo-protection all throughout life</span><span lang="EN-IN">. </span></p>
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Ishioka, Priscila, Sílvio Alencar Marques, Amélia Toyomi Hirai, Mariangela E. A. Marques, Sérgio Henrique Hirata y Sérgio Yamada. "Prevalence of precancerous skin lesions and non-melanoma skin cancer in Japanese-Brazilians in Bauru, São Paulo State, Brazil". Cadernos de Saúde Pública 25, n.º 5 (mayo de 2009): 965–71. http://dx.doi.org/10.1590/s0102-311x2009000500003.
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Precancerous lesions and skin cancer are infrequent in Asians, and have received little documentation in the literature. Brazil has the world's largest contingent of Japanese immigrants and their descendants, and 70% live in the State of São Paulo. The prevalence of such skin lesions in Japanese-Brazilians is unknown. This study aimed to assess the prevalence of actinic keratoses and non-melanoma skin cancer in first and second-generation Japanese-Brazilians over 30 years of age, without miscegenation, living in the city of Bauru, São Paulo State, in 2006. Of the 567 Japanese-Brazilians that underwent dermatological examination, actinic keratosis was diagnosed in 76, with a mean age of 68.9 years, and a single case of basal cell carcinoma was detected in a 39-year-old female patient. In Japan, prevalence of actinic keratosis varies from 0.76% to 5%, and the incidence of non-melanoma skin cancer is 1.2 to 5.4/100 thousand. Japanese-Brazilians from Bauru showed a 13.4% prevalence of actinic keratoses and earlier age at onset. Proximity to the Equator and a history of farming contribute to these higher rates. Presence of solar melanosis was associated with a 1.9-fold risk of developing actinic keratosis.
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Niu, Dongfeng, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang y Chen Zhao. "Expression and Significance of AQP3 in Cutaneous Lesions". Analytical Cellular Pathology 2021 (26 de octubre de 2021): 1–6. http://dx.doi.org/10.1155/2021/7866471.
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Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. AQP3 mRNA was detected in normal epidermis, seborrheic keratosis, solar keratosis, Bowen’s disease, squamous cell carcinoma, eccrine poroma, apocrine carcinoma, and sebaceoma; however, AQP3 mRNA was absent in basal cell carcinoma, nevocellular nevus, or malignant melanoma. By immunohistochemistry, diffuse AQP3 expression was seen in all keratotic lesions including seborrheic keratosis, verruca vulgaris, molluscum contagiosum, solar keratosis, Bowen’s disease, and squamous cell carcinoma. Diffuse AQP3 expression was also present in all extramammary Paget’s disease. No AQP3 staining was obtained in basal cell carcinoma. Positive AQP3 staining was seen in sweat gland tumors including hidradenoma, eccrine poroma, and apocrine carcinoma. Among sebaceous tumors, AQP3 expressed diffusely in all sebaceous hyperplasia and sebaceous adenoma, but not in sebaceous carcinomas. Only focal AQP3 staining was seen in nevocellular nevus and no AQP3 staining in melanoma. Our findings indicate the function of AQP3 maintained in most skin tumors. AQP3 may be used for differential diagnosis in skin tumors.
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Gimeno-Castillo, Javier, Adriano Pablo Martínez Aracil y Aida Menéndez Parrón. "Blue scales on an “iced” scalp". Our Dermatology Online 13, n.º 3 (1 de julio de 2022): 311–12. http://dx.doi.org/10.7241/ourd.20223.18.
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Although the diagnosis of actinic keratosis (AK) is mainly clinical, dermoscopy is a highly useful and accurate diagnostic technique. The dermoscopic features of AK include the strawberry pattern with white areas, keratotic, follicular openings, a pseudonetwork, and rosettes [1]. An 82-year-old male with a personal history of type 3 autoimmune polyglandular syndrome and hypertension was referred to the dermatology department due to the presence of scaly lesions located on the scalp and forehead. A physical examination revealed asymptomatic, keratotic lesions on the forehead and in the occipital region (Fig. 1a). The patient denied the application of any product except toning shampoo for white hair. Interestingly, the lesions had a blue, superficial scale, although they clinically resembled AK. Dermoscopy evidenced an erythematous background with multiple, arctic-blue, keratotic plugs (Fig. 1b). Moreover, a superficial excision of one of the lesions was performed, evidencing solar elastosis and a chronic dermal infiltrate, as well as basal keratinocytes with loss of polarity, presenting with irregular nuclei (Fig. 2). Thus, the clinical and pathological correlation confirmed the diagnosis of AK. The lesions were treated with cryotherapy leading to their resolution. Figure 1: (a) Clinical presentation of the cutaneous lesions: numerous bluish-gray, scaly lesions in the occipital area; the patient confirmed using toning shampoo for white hair containing Acid Violet 43. (b) Dermoscopy of one of the lesions: an erythematous background, as well as numerous arctic-blue, keratotic plugs; the blue scale compatible with the iceberg sign present in AK neglecta. Figure 2: Solar elastosis and a chronic dermal infiltrate, as well as basal keratinocytes with loss of polarity presenting with irregular nuclei; findings compatible with the clinical suspicion of AK; no basophilic amorphous material present in the stratum corneum (H&E, 20×). Blue AK has been termed AK neglecta while the dermoscopic blue coloration the iceberg sign [2,3]. The latter is described to be caused both by sunscreens containing titanium dioxide [3] or shampoos containing Acid Violet (present in the shampoo that the patient used) [2]. Moreover, this exogenous pigmentation may easily be removed with alcohol [3]. Histologically, a basophilic amorphous material on the stratum corneum is described to be present [2]. A lack of this finding in our case might have been explained due to the 10% formol used to preserve the biopsy, eliminating the pigment. Recognizing this presentation is essential due to the widespread use of toning shampoos and sunscreens among the elder population.
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Millanta, Francesca, Francesca Parisi, Alessandro Poli, Virginia Sorelli y Francesca Abramo. "Auricular Non-Epithelial Tumors with Solar Elastosis in Cats: A Possible UV-Induced Pathogenesis". Veterinary Sciences 9, n.º 2 (18 de enero de 2022): 34. http://dx.doi.org/10.3390/vetsci9020034.
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The photoinduced etiopathology of actinic keratosis and squamous cell carcinoma in feline species is well known. This etiology has also been reported for non-epithelial cutaneous tumors in other species. To date, no cases of auricular non-epithelial cutaneous neoplasms erased in a contest of actinic keratosis in cats have been reported. The aim of this study was to describe feline auricular non-epithelial cutaneous neoplasms associated with typical UV-induced cutaneous lesions and solar elastosis. The study was conducted on five feline cases diagnosed with auricular non-epithelial cutaneous tumors (two fibrosarcomas, one mixosarcoma, one epithelioid melanoma and one hemangiosarcoma), selected from the Tumor Registry of the Department of Veterinary Sciences of the University of Pisa (1998–2018). Ten and six feline auricular biopsies of normal skin and skin with actinic keratosis, respectively, were used as controls. Orcein stain was used to investigate solar elastosis. Histological changes related to chronic solar irradiation were documented in the skin adjacent to the neoplastic lesions in the five cats. Considering the anatomical localization and the results of histopathology, this study suggests that non-epithelial cutaneous neoplasms may have a UV-induced etiopathogenesis in the feline species.
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Karadaglić, Đorđije y Marina Jovanović. "Actinic Keratosis: A New Approach to the Treatment / Aktinična Keratoza: Novi Pristup Lečenju". Serbian Journal of Dermatology and Venerology 1, n.º 1 (1 de enero de 2009): 27–33. http://dx.doi.org/10.2478/v10249-011-0004-1.
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Abstract Actinic keratosis is an intraepidermal proliferation of transformed, atypical keratinocytes, induced by exposure to solar ultraviolet radiation. Many authors believe that it is the earliest form of squamous cell carcinoma. More than 40% of all metastatic squamous cell carcinomas develop from actinic keratosis. The clinical, histological and molecular characteristics of actinic keratosis are those of squamous cell carcinomas. Since it can be extremely hard to distinguish actinic keratosis from some squamous cell carcinomas, treatment can be rather difficult. The best treatment of actinic keratosis is its prevention. The main reason for therapy which is universally accepted, is prevention of squamous cell carcinoma. A number of options are available, but when considering the efficacy, invasive procedures remain the standard treatment. Treatment of individual lesions may prevent further progression of actinic damage present in the surrounding skin
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Goncharova, Yana, Enas A. S. Attia, Khawla Souid y Inna V. Vasilenko. "Dermoscopic Features of Facial Pigmented Skin Lesions". ISRN Dermatology 2013 (3 de febrero de 2013): 1–7. http://dx.doi.org/10.1155/2013/546813.
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Four types of facial pigmented skin lesions (FPSLs) constitute diagnostic challenge to dermatologists; early seborrheic keratosis (SK), pigmented actinic keratosis (AK), lentigo maligna (LM), and solar lentigo (SL). A retrospective analysis of dermoscopic images of histopathologically diagnosed clinically-challenging 64 flat FPSLs was conducted to establish the dermoscopic findings corresponding to each of SK, pigmented AK, LM, and SL. Four main dermoscopic features were evaluated: sharp demarcation, pigment pattern, follicular/epidermal pattern, and vascular pattern. In SK, the most specific dermoscopic features are follicular/epidermal pattern (cerebriform pattern; 100% of lesions, milia-like cysts; 50%, and comedo-like openings; 37.50%), and sharp demarcation (54.17%). AK and LM showed a composite characteristic pattern named “strawberry pattern” in 41.18% and 25% of lesions respectively, characterized by a background erythema and red pseudo-network, associated with prominent follicular openings surrounded by a white halo. However, in LM “strawberry pattern” is widely covered by psewdonetwork (87.5%), homogenous structureless pigmentation (75%) and other vascular patterns. In SL, structureless homogenous pigmentation was recognized in all lesions (100%). From the above mentioned data, we developed an algorithm to guide in dermoscopic features of FPSLs.
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Mazzilli, Sara, Reyes Gamo-Villegas, Ana Pampin-Franco, Jose Luis Lopez Estebaran, Fernando Pinedo, Laura Vollono, Monia Di Prete, Elena Campione y Salvador Gonzalez. "Reflectance Confocal Microscopy of Pigmented Bowen’s Disease: A Case Series of Difficult to Diagnose Lesions". Case Reports in Dermatology 12, n.º 2 (15 de mayo de 2020): 98–106. http://dx.doi.org/10.1159/000507916.
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Pigmented Bowen’s disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. The best-characterized feature of the disease by histological examination is the presence of atypical keratinocytes, hyperpigmentation of the epidermis with trans-epidermal elimination of melanin and dermal melanophages. Precise diagnosis is often difficult, both clinically and dermoscopically, as Bowen’s disease is often mistaken with keratinocyte tumors such as solar lentigines, seborrheic keratosis, Bowenoid papulosis, pigmented basal cell carcinoma, pigmented actinic keratosis; or even melanocytic lesions such as melanocytic nevus, pigmented epithelioid melanocytoma, and melanoma. Precise diagnosis often requires biopsy and histopathological examination of the tissue. Reflectance confocal microscopy is a noninvasive technique to diagnose pigmented skin lesions. To date, not much data are available regarding its use in the diagnosis of pigmented Bowen’s disease. Herein, we report a well-represented case series of pigmented Bowen’s disease imaged using dermoscopy and reflectance confocal microscopy.
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Marçon, Carolina Reato, José Cassio Moraes, Marcus Antonio Maia de Olivas Ferreira y Camilla Bilac Oliari. "Dermatological and Epidemiological Profiles of Patients with Albinism in São Paulo, Brazil, between 2010 and 2017: A Cross-Sectional Study". Dermatology 236, n.º 3 (28 de agosto de 2019): 219–27. http://dx.doi.org/10.1159/000502034.
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Introduction: Oculocutaneous albinism is an autosomal recessive disease caused by complete absence of or decrease in melanin biosynthesis in melanocytes. Due to the reduction or absence of melanin, albinos are highly susceptible to the harmful effects of ultraviolet radiation and are at greater risk of actinic damage and skin cancer. There are no epidemiological data on the incidence of albinism in Brazil. Objective: To analyze the clinical and epidemiological profile of patients with albinism treated by the Pró-Albino Program of the Dermatology Clinic of Santa Casa de Misericórdia from its beginning in 2010 until 2017. Methods: In this cross-sectional study, the records of all consecutive albino patients admitted to the service in the study period were reviewed. Sociodemographic data, family history, and dermatological clinical data were collected. Results: Between March 2010 and April 2017, 191 patients were admitted, of whom 109 were female (57.07%) and the age range was 0–92 years, with >30% under the age of 18 years. Consanguinity among the parents was confirmed by 26% of the patients. Unprotected sun exposure was reported by 109 (57.07%), and 138 (72.25%) had a history of sunburn. Of the 146 records with information, 38 had skin cancer (26%), with a mean age of 47.4 (p < 0.0001); the youngest patient diagnosed with a cutaneous tumor was 23 years old. The prevalence of actinic damage was high. There was information on solar elastosis and actinic keratosis in 148 medical records, of which 96 (64.8%) patients had elastosis and 75 (50.67%) keratoses. Elastosis, keratosis, and skin cancer were significantly associated with age, unprotected sun exposure, and sunburn (p < 0.05). Of the 37 (26% of the sample of 146) patients with a previous or current history of skin cancer, it was possible to identify the histological type in 29 (13 men and 16 women); of these, 18 (62%) were basal cell carcinomas (BCC), 15 (51%) were squamous cell carcinomas (SCC), and 2 (7%) were melanomas. Of these, 4 cases (14%) presented the 2 types of carcinoma (BCC and SCC), and the 2 that had a diagnosis of melanoma also had BCC. Some patients had multiple ulcerated tumors. The tumor site was preferentially in the head and neck (43%), trunk (37%) and limbs (20%). Conclusions: Albinos represent a risk group for skin cancer and other actinic lesions. These lesions were found to be prevalent in the albinos seen by the program and probably reflect the characteristics found in the Brazilian albino population. Access to health care, especially through multidisciplinary programs that enable the diagnosis and early treatment of these lesions, health education, and the use of photoprotective measures can reduce morbidity and mortality and improve the quality of life of patients with this rare genetic condition.
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Deonizio, Janyana, Betina Werner y Fabiane A. Mulinari-Brenner. "Histological Comparison of Two Cryopeeling Methods for Photodamaged Skin". ISRN Dermatology 2014 (12 de marzo de 2014): 1–5. http://dx.doi.org/10.1155/2014/950754.
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Background. Cryopeeling is a technique that uses cryotherapy not only on actinic keratoses lesions, but also all over the photodamaged skin. Objectives. To investigate the histological changes induced by two cryopeeling methods (liquid nitrogen (LN) and portable system (PS)). Methods. Sixteen patients (n=16) with multiple actinic keratoses on the forearms were treated with cryopeeling technique using LN for one forearm and PS for the other, randomly. Skin biopsies were taken before and after the procedures. Results. There was no statistical difference between the epidermal and Grenz zone thicknesses or density of elastic fibers after treatments. The amount of melanin pigment was lower after PS treatment (P<0.05). In a blind analysis of paired pre- and postprocedure slides, it was not possible to identify cases which underwent treatment, both in global analysis of quality of the skin and in specific analysis (considering only the aspect of stratum corneum). Discussion. The results indicate the inconsistency of histological improvement after treatments, and, likely, since the method causes superficial exfoliation, a reliable marker was not found in the analysis. Conclusions. Despite cosmetic benefits on photodamaged skin and efficient treatment of actinic keratoses lesions, cryopeeling was not able to induce measurable histological changes in solar elastosis, epidermal organization, or epidermal and Grenz zone thicknesses. One should keep in mind the possibility of hypopigmentation risk of the method.
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Ramji, Ashwath Narayan. "Cutaneous horn in a sun-protected site harbouring unusual malignancy". International Surgery Journal 6, n.º 4 (26 de marzo de 2019): 1415. http://dx.doi.org/10.18203/2349-2902.isj20191291.
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Cutaneous horns are conical, circumscribed projections formed by desquamation and layering of keratin. Although they can appear on the skin anywhere on the body, they are most commonly seen on the sun-exposed surfaces, and are often associated with solar keratosis. Cutaneous horns are most often benign, however they are a potential site of malignancy and may harbor premalignant or malignant lesions, the most common being squamous cell carcinoma, the causal relationship being straightforward and both squamous cell carcinoma and cutaneous horns can be equated with the common epithelial maker keratin. Other histological types of malignancies are not usually noted in conjunction with cutaneous horns. Here we describe a patient with a cutaneous horn over the volar aspect of the right forearm, a sun-protected site, harboring basal cell carcinoma, an infrequent finding.
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LEVER, L. y R. MARKS. "The significance of the Darier-like solar keratosis and acantholytic change in preneoplastic lesions of the epidermis". British Journal of Dermatology 120, n.º 3 (marzo de 1989): 383–89. http://dx.doi.org/10.1111/j.1365-2133.1989.tb04164.x.
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G Bianchi, Mara, Andre Santos y Eduardo Cordioli. "Benefits of Teledermatology for Geriatric Patients: Population-Based Cross-Sectional Study". Journal of Medical Internet Research 22, n.º 4 (21 de abril de 2020): e16700. http://dx.doi.org/10.2196/16700.
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Background Teledermatology is a health care tool that has been increasingly used around the world, mostly because dermatology has an emphasis on visual diagnosis. Many studies have shown that access to specialized care improves using teledermatology, which provides accurate diagnosis and reduces the time taken for treatment, with high patient satisfaction. As the population around the world grows old, there will be even more demand for dermatologists in years to come. It is essential to know which are the most prevalent skin conditions in the primary care population and if they can be addressed through teledermatology. Objective Our main goal was to evaluate the proportion of lesions in individuals aged 60 years and older that could be managed using teledermatology in conjunction with primary care physicians. Second, we aimed to assess the most frequent skin lesions, the most common treatments provided to patients, and the distribution and causes of referrals made by the teledermatologists. Methods This was a retrospective cohort study from July 2017 to July 2018 in São Paulo, Brazil. We included 6633 individuals aged 60 years and older who presented with 12,770 skin lesions. Teledermatologists had three options to refer patients: (1) to undergo biopsy directly, (2) to an in-person dermatologist visit, and (3) back to the primary care physician with the most probable diagnosis and treatment. Results Teledermatology managed 66.66% (8408/12614) of dermatoses with the primary care physician without the need for an in-presence visit; 27.10% (3419/12614) were referred to dermatologists, and 6.24% (787/12614) directly to biopsy. The most frequent diseases were seborrheic keratosis, solar lentigo, onychomycosis, melanocytic nevus, benign neoplasms, actinic keratosis, epidermoid cyst, xerosis, leucoderma, and wart, with significant differences between sexes. Malignant tumors increased with age and were the leading cause for biopsies, while infectious skin conditions and pigmentary disorders decreased. Emollient was the most frequent treatment prescribed, in 31.88% (909/2856) of the cases. Conclusions Teledermatology helped to treat 67% of the dermatoses of older individuals, addressing cases of minor complexity quickly and conveniently together with the primary care physician, thus optimizing dermatological appointments for the most severe, surgical, or complex diseases. Teledermatology does not aim to replace a face-to-face visit with the dermatologist; however, it might help to democratize dermatological treatment access for patients and decrease health care expenses.
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David, Laurence M., Edward Glassberg y Gary P. Lask. "Combined Carbon Dioxide Laser Resurfacing and TCA Chemical Peel". American Journal of Cosmetic Surgery 9, n.º 2 (junio de 1992): 153–58. http://dx.doi.org/10.1177/074880689200900207.
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Currently, various modalities such as phenol and TCA peels and dermabrasion are available for regeneration of the aged skin. A prior study by our group has demonstrated the clinical effectiveness of CO2 laser resurfacing in treating actinically damaged skin of the entire face with concomitant histologic improvement characterized by elimination of the solar elastosis and replacement by new collagen bundles. In the present study, we have taken this approach one step further and are presenting results of a series of 130 patients treated with combined CO2 laser resurfacing and trichloracetic acid (TCA) chemical peeling. The laser is used primarily for wrinkles, keratotic lesions, and pigmentary changes; and TCA is used to blend affected and unaffected skin. Fewer complications were noted with CO2 laser resurfacing/TCA peels than with phenol peels or dermabrasion. This combined technique can be a useful modality in the cosmetic as well as therapeutic treatment of the aged skin, as marked clinical and histologic improvement has been demonstrated.
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Schaumburg-Lever, G., J. Alroy, A. Ucci y W. F. Lever. "Cell surface carbohydrates in proliferative epidermal lesions.. II. Masking of peanut agglutinin (PNA) binding sites in solar keratoses, Bowen's disease, and squamous cell carcinoma by neuraminic acid." Journal of Cutaneous Pathology 13, n.º 2 (abril de 1986): 163–71. http://dx.doi.org/10.1111/j.1600-0560.1986.tb01517.x.
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Gomes, Gabriela Pereira, Aparecida Machado Moraes, Hamilton Ometto Stoff y Laura Sterian Ward. "Allelic imbalance studies of chromosome 9 suggest major differences in chromosomal instability among nonmelanoma skin carcinomas". Sao Paulo Medical Journal 122, n.º 1 (febrero de 2004): 18–21. http://dx.doi.org/10.1590/s1516-31802004000100005.
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CONTEXT: Loss of heterozygosity in the 9p21-p22 region, has been frequently described in a wide range of human malignancies, including familial melanomas. Also, losses and gains in other regions of chromosome 9 have frequently been observed and may indicate additional mechanisms for basal cell tumorigenesis. OBJECTIVE: To investigate allelic imbalance in the 9p21-p22 region, among basal cell carcinomas. TYPE OF STUDY: Microsatellite analysis. SETTING: Two dermatology services of public universities in São Paulo and the Laboratory of Cancer Molecular Genetics of Universidade Estadual de Campinas (Unicamp). PARTICIPANTS: 13 patients with benign skin lesions consecutively referred to the outpatient dermatology clinics of Unicamp and Universidade Estadual de São Paulo (Unesp) and 58 with malignant skin tumours. MEAN MEASUREMENTS: We examined 13 benign cases including four of solar keratosis, three keratoachanthomas, three melanocytic nevi, two of Bowen's disease and one of neurofibroma, and 58 malignant skin tumors: 14 of squamous cell, 40 basal cell carcinomas and four melanomas. Participating patients had the main tumor and a normal portion of non-adjacent skin surgically removed. DNA was extracted from the tumor and matching normal tissue. We used four sets of primers to amplify polymorphic microsatellite repeats on chromosome 9, two of them targeting the 9p21-p22 region. RESULTS: We identified eight cases (20%) of allelic imbalance among basal cell carcinomas, two cases of loss of heterozygosity and six cases of microsatellite instability in the 9p21-p22 region. Additional markers were also involved in three of these tumors. No events were detected among the benign or the other malignant cases. CONCLUSION: This phenotype dependency suggests that there is a major distinction between the two most important forms of nonmelanoma skin cancers in their tendency to present microsatellite instability in chromosome 9. Since the CDKN2a/p16INK4a, p19ARF and p15INK4b tumor suppressor genes do not appear to be responsible for the observed abnormalities, other genes at 9p21-p22 may be involved in the pathogenesis and progression pathway of basal cell carcinomas.
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Giavina-Bianchi, Mara. "Teledermatology in São Paolo, Brazil". Iproceedings 8, n.º 1 (10 de febrero de 2022): e36899. http://dx.doi.org/10.2196/36899.
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Background There are places in the world where access to dermatologists can be very challenging and general practitioners may not be well trained in the diagnosis and treatment of skin conditions. Store-and-forward teledermatology may improve access to specialty care, provide accurate diagnoses, and reduce time to treatment, resulting in high patient satisfaction. The early detection and timely treatment of severe skin diseases could prevent adverse health outcomes and death. On the other hand, some skin conditions such as mild atopic dermatitis, acne, and fungal infections could be managed within primary care using teledermatology. Objective We aimed to (1) evaluate the proportion of individuals who could be assessed in primary care using teledermatology and how this affects the waiting time for an in-person dermatologist appointment and (2) assess the most frequent dermatoses according to demographic data and referrals made by the teledermatologist. Methods A cross-sectional retrospective study, involving 30,976 individuals and 55,624 skin lesions, was conducted from July 2017-July 2018 in the city of São Paulo. We assessed the frequency of diagnoses and referrals to biopsy, in-person dermatologists, or primary care, and compared the waiting time for an in-person dermatologist appointment before and after the teledermatology implementation. Results We found that 53% of the patients were managed by the primary care physician, 43% were referred to in-person dermatologists, and 4% were referred directly to biopsy, leading to a reduction in waiting time for in-person appointments of 78% when compared to the previous period (from 6.7 months to 1.5 months). The most frequent diseases were melanocytic nevus, seborrheic keratosis, acne, benign neoplasms, onychomycosis, atopic dermatitis, solar lentigo, melasma, xerosis, and epidermoid cyst, with significant differences according to sex, age, and referrals (Multimedia Appendix 1A,B). Conclusions The use of teledermatology as a triage tool significantly reduced the waiting time for in-person visits, improving health care access and using public resources wisely. Knowledge of sex, age, diagnoses, and treatment of common skin conditions can enable the creation of public policies for prevention and orientation of the population, as it can be used to train general physicians to address such cases. Conflicts of Interest None declared.
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"Accuracy Assessment & Classification of Keratosis Skin Lesion Images using Feature Extraction & Classification Algorithms-LBP, LDP& HOG". International Journal of Innovative Technology and Exploring Engineering 9, n.º 6 (10 de abril de 2020): 397–403. http://dx.doi.org/10.35940/ijitee.f3737.049620.
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There are hundreds of human-affected skin diseases. The most severe skin disorders may have identical symptoms, so recognizing the distinctions between them is crucial. People should work closely with a dermatologist to identify and manage every skin disorder and insure it does not impact their lifestyle.Actinic keratosis (AK), that is also classified as solar or senile keratosis; is a pre-malignant crusty, thick skin area. It is a disorder of epidermal keratinocytes, induced by UV radiation upon the skin. While pre-cancerous in nature, they can develop into a form of skin cancer called carcinoma if left unaddressed. The other type of keratosis dealt within this paper is seborrheic keratosis, which are brown or black, thick, wart-like, waxy oval-shaped, slightly raised skin surfaces. The growths aren't damaging. Nevertheless, in some instances it can be impossible to differentiate a seborrheic keratosis from melanoma, which is a very dangerous form of skin cancer.Nevus (or moles) skin lesions are ones which are benign, where it may very rarely turn into melanoma skin cancer. In this article, along with techniques for extracting features (LDP [Local Directional Patterns], LBP [Local Binary Patterns] and HOG [Histogram of Oriented Gradients]),we have used an SVM classifier for the classification of Keratosis and also nevus skin photos. The LBP, LDP and HOG are means to extract features; these images are subsequently used for identification of derived features from these methods or algorithms and classified by the SVM (Support Vector Machine) classifier. For many of the classifications of keratosis and nevus skin images using these algorithms, we have obtained accuracy nearly above 80 %, whereby the LBP system together with the SVM classifier was the most powerful attribute extraction tool of the three with their polynomial kernel type. Using this algorithm-classifier,the main AK and nevus skin lesion images can be detected and diagnosed by the doctors in its early stage itself,thus helping save lives.
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Mishra, Apurva. "Solar keratosis". InnovAiT: Education and inspiration for general practice, 10 de marzo de 2022, 175573802210836. http://dx.doi.org/10.1177/17557380221083692.
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Solar keratosis is a common skin condition characterised by scaly skin lesions, usually found on sun-exposed areas of the body. It is also known as actinic keratosis, senile keratosis and solar keratosis; the name originates from Latin and means ‘skin thickening due to sun'. It was first described by Dubreuilh in 1826, and for many years was known as ‘keratoma senilis’. In 1958 it was finally named actinic keratosis, by Pinkus. Solar keratotsis represents dysplastic proliferations of keratinocytes, secondary to chronic sun exposure, especially ultra-violet radiation. Solar keratosis is the most common pre-malignant skin condition; however, it is increasingly thought to represent a spectrum of disease in between photo-damaged skin and squamous cell carcinoma (SCC). A small proportion of solar keratosis progresses to become SCC, and the chances of progression increase with the increase in the number of lesions. Incidence of solar keratosis in the UK is increasing due to an ageing population, leading to increased burden on the healthcare system.
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Zhang, Guolong, Guorong Yan, Zhiliang Fu, Yuhao wu, Fei Wu, Zhe Zheng, Shan Fang et al. "Loss of retinoic acid receptor-related receptor alpha (Rorα) promotes the progression of UV-induced cSCC". Cell Death & Disease 12, n.º 3 (marzo de 2021). http://dx.doi.org/10.1038/s41419-021-03525-x.
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AbstractCutaneous squamous cell carcinoma (cSCC) is prevalent in the world, accounting for a huge part of non-melanoma skin cancer. Most cSCCs are associated with a distinct pre-cancerous lesion, the actinic keratosis (AK). However, the progression trajectory from normal skin to AK and cSCC has not been fully demonstrated yet. To identify genes involved in this progression trajectory and possible therapeutic targets for cSCC, here we constructed a UV-induced cSCC mouse model covering the progression from normal skin to AK to cSCC, which mimicked the solar UV radiation perfectly using the solar-like ratio of UVA and UVB, firstly. Then, transcriptome analysis and a series of bioinformatics analyses and cell experiments proved that Rorα is a key transcript factor during cSCC progression. Rorα could downregulate the expressions of S100a9 and Sprr2f in cSCC cells, which can inhibit the proliferation and migration in cSCC cells, but not the normal keratinocyte. Finally, further animal experiments confirmed the inhibitory effect of cSCC growth by Rorα in vivo. Our findings showed that Rorα would serve as a potential novel target for cSCC, which will facilitate the treatment of cSCC in the future.
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Baretta, Leticia Talita, Juliana De Oliveira Dhein, Camila Gottlieb Lupion, Cristiane Deon Figueiredo y Daniel Guimarães Gerardi. "Occurrence of Cutaneous Neoplasia in Dogs with Actinic Dermatitis in a Veterinary Medical Teaching Hospital - UFRGS, Brazil". Acta Scientiae Veterinariae 49 (15 de marzo de 2021). http://dx.doi.org/10.22456/1679-9216.108639.
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Background: Actinic dermatitis is an environmental skin disease resulting from excessive exposure to ultraviolet light irradiated by the sun. This phototoxic reaction affects dogs and cats, particularly with short hair and lightly pigmented skin, exposed to sun light. Primary lesions are typical from a sunburn and chronic exposure, and may induce to a premalignant lesion known as actinic keratosis, which may develop to neoplasms. The aim of the present study was to describe a retrospective study of actinic dermatitis and the occurrence of cutaneous neoplasia in dogs presented to a Veterinary Medical Teaching Hospital (HCV/UFRGS) in Porto Alegre, Rio Grande do Sul, Brazil in a period of 10 years.Materials, Methods & Results: A retrospective review of medical records from January 2009 to December 2019 was performed to identify dogs with actinic dermatitis. Twenty-eight dogs were diagnosed based on a history of sun exposure and skin lesions including erythema, scaling, comedones, thickened skin, hyperpigmentation, ulceration and/or secondary infections on poorly pigmented skin. In addition, in twelve dogs (42.8%) the disease was also confirmed by histopathology. Cutaneous lesions locations were previously defined as head, limbs, neck and trunk. The head was subdivided in chin, ears, face, lips and nasal plane; the limbs in pelvic and thoracic; and the trunk, in abdomen, dorsal pelvis, perianal and thorax. All 28 dogs diagnosed with actinic dermatitis in the study had been chronically exposed to solar radiation and had light skin and coat. Dogs were between 3 and 20 years old, mean 7.6 years and median 7 years, mostly female dogs (64.2%) and neutered or spayed (64.2%). The most affected breeds were American Pitbull Terrier (35.7%) and Boxers (28.5%). Other breeds were Bull Terrier, Dalmatian, Dogo Argentino and Scottish Terrier. In 15 cases, tumors were confirmed by cytopathology or histopathology, resulting in 9 different skin tumors and two types of cysts (epidermoid and follicular). Among these, the most prevalent malignant neoplasm was squamous cell carcinoma (66.7%), followed by mast cell tumor (40%), hemangiosarcoma (26.6%), and basal cell carcinoma (6.6%). Five benign tumors were identified: hemangioma (13.3%), fibroma (6.6%), lipoma (6.6%), sebaceous adenoma (6.6%) and trichoepithelioma (6.6%). The most prevalent location for actinic lesions was the trunk (92.8%), being more prevalent on the ventral abdomen (82.1%). Actinic lesions were also present on head, neck and limbs. In 13/15 patients (86.6%), actinic lesions and at least one neoplasia location matched.Discussion: Actinic dermatitis tends to occurs in mid-aged to senile dogs because of the disease progressive and chronic behavior and owners delay to detect early clinical signs. In fact, actinic dermatitis was diagnosed at the average age of 7.6 years in the present study. The skin lesions were mostly located on light hair areas and were not observed on pigmented skin. The trunk (mainly the abdomen) had higher frequency of skin lesions compared to other anatomic areas, possibly because some dogs like to sunbathe at dorsal or lateral recumbency, some floor types can reflect sunlight, and some ventral abdomen are hairless. Ultraviolet radiation causes important local and systemic immunogenic changes. The impairment of the immune system and antigen recognition can influence cutaneous susceptibility to develop neoplasm. In conclusion, approximately 50% of the dogs with actinic dermatitis were associated with different skin neoplasm. The most prevalent was squamous cell carcinoma, mast cell tumor and hemangiosarcoma. Actinic lesions and neoplasm matched location in almost all patients with both conditions, however it was not possible to define if solar radiation had predisposed the occurrence of all observed neoplasms. Further studies are needed to prove the influence of ultraviolet radiation in the development of different cutaneous neoplasms.
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Gouda, Gracy, John Pyne y Tony Dicker. "Pigmented macules on the head and neck". Dermatology Practical & Conceptual, 31 de octubre de 2022, e2022194. http://dx.doi.org/10.5826/dpc.1204a194.
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Introduction: Differentiating early melanoma from other flat pigmented lesions on the head and neck is challenging both clinically and dermoscopically, partly due to the wide differential diagnosis and the lack of specific diagnostic algorithms. Objectives: To review publications covering the dermoscopic features of pigmented macules on the head and neck. Methods: Embase and PubMed (Medline) database from Jan 2015 to Jan 2021 were searched using a four-step search. Keywords used were dermoscopy/dermatoscopy or epiluminescence microscopy, lentigo maligna (LM), lentigo maligna melanoma (LMM), lichen-planus-like-keratosis (LPLK), solar lentigo (SL), seborrhoeic keratosis (SK), pigmented actinic keratosis (PAK), pigmented Bowen’s disease (pBD), pigmented intraepidermal carcinoma (pIEC) and head and neck. Results: The commonest reported dermoscopic features of facial melanoma were irregular dots, atypical dots/globules, asymmetric pigmented follicular openings (APFO), rhomboid grey/ black structures, increased vascular network, brown globules/dots and a pattern of circles. Pseudopods, radial streaming, blue white veil, irregular blotches, scar-like depigmentation and atypical pigment network were recorded in low frequencies. For PAK, pBD and pIEC perifollicular erythema, white/yellow surface scale, linear wavy vessels around hair follicles, hair follicular openings surrounded by a white halo, evident follicles or follicular or keratotic plugs, rosette sign and sharply demarcated borders were the salient features. Conclusions: Further studies are needed to determine the dermoscopic criteria for pigmented melanocytic and non-melanocytic lesions on the head and neck. Furthermore, there is a gap in the knowledge of site-specific dermoscopic features on specific sites, namely ears, nose, cheeks, scalp and neck which will also benefit from further studies.
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Mirbeik, Amir, Robin Ashinoff, Tannya Jong, Allison Aued y Negar Tavassolian. "Real-time high-resolution millimeter-wave imaging for in-vivo skin cancer diagnosis". Scientific Reports 12, n.º 1 (23 de marzo de 2022). http://dx.doi.org/10.1038/s41598-022-09047-6.
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AbstractHigh-resolution millimeter-wave imaging (HR-MMWI), with its high discrimination contrast and sufficient penetration depth, can potentially provide affordable tissue diagnostic information noninvasively. In this study, we evaluate the application of a real-time system of HR-MMWI for in-vivo skin cancer diagnosis. 136 benign and malignant skin lesions from 71 patients, including melanoma, basal cell carcinoma, squamous cell carcinoma, actinic keratosis, melanocytic nevi, angiokeratoma, dermatofibroma, solar lentigo, and seborrheic keratosis were measured. Lesions were classified using a 3-D principal component analysis followed by five classifiers including linear discriminant analysis (LDA), K-nearest neighbor (KNN) with different K-values, linear and Gaussian support vector machine (LSVM and GSVM) with different margin factors, and multilayer perception (MLP). Our results suggested that the best classification was achieved by using five PCA components followed by MLP with 97% sensitivity and 98% specificity. Our findings establish that real-time millimeter-wave imaging can be used to distinguish malignant tissues from benign skin lesions with high diagnostic accuracy comparable with clinical examination and other methods.
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Katz, Ian, Tony Azzi, Alister Lilleyman, Blake O'Brien, Brian Schapiro, Curtis Thompson y Tarl Prow. "Variability in the Histopathological Diagnosis of Nonmelanocytic Lesions Excised to Exclude Melanoma". Dermatology Practical & Conceptual, 29 de octubre de 2021, e2021094. http://dx.doi.org/10.5826/dpc.1104a94.
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Introduction. The differential diagnosis of lesions excised to exclude melanoma include a variety of benign and malignant melanocytic and non-melanocytic lesions.
Objectives. We examined the variability between pathologists in diagnosing non-melanocytic lesions.
Methods. As part of a larger study prospectively examining the diagnosis of lesions excised to exclude melanoma in 198 patients at a primary care skin cancer clinic in Newcastle, Australia, we compared diagnosis made by 5 experienced dermatopathologists, of 44 non-melanocytic lesions in 44 patients aged 22-90.
Results. Forty-four lesions (out of 217 in total) were non-melanocytic. Among the 5 pathologists who examined each case there was marked variability in the terminology used to diagnose each case. The most common variability was found between seborrheic keratosis, large cell acanthoma, solar lentigo, and lichenoid keratosis. The diagnosis made by the majority of the pathologists was deemed to be the reference diagnosis. Versus majority diagnosis, 4% of benign lesions were considered malignant, and 7% of malignant diagnoses were considered as benign.
Conclusions. The different terminology adopted and lack of consensus in the diagnosis of these non-melanocytic lesions in this setting suggests that training AI systems using gold standards may be problematic. We propose a new management classification scheme called MOLEM (Management of Lesions Excised to exclude Melanoma) which expands the previously described MPATH-dx to include non-melanocytic lesions.
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García, Juan Agustín, Carina Quinteros, Agustín Romero y Fernando Dutra. "Occurrence of squamous cell carcinoma in Milchschaf sheep in Uruguay". Ciência Rural 48, n.º 1 (18 de diciembre de 2017). http://dx.doi.org/10.1590/0103-8478cr20170406.
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ABSTRACT: In this study, the epidemiological and pathological features of an outbreak of squamous cell carcinoma (SCC) in adult female sheep and a young ram, Friesian Milchschaf breed or crossbreed is described. Seven adult females belonging to an original flock nucleus of 20 animals were affected, as well as a young ram belonging to the same nucleus was affected in other establishment. Multiple verrucous neoplastic masses of several months of evolution were evident in the head region, with local invasion and regional lymph node metastases. Histological studies revealed a cancerous stage of invasion of the dermis and neoplastic proliferation characteristic of invasive SCC, and a pre-cancerous stage with solar elastosis and chronic solar keratosis lesions induced by sunlight. Decrease in latitude, increased level of solar radiation with long exposure to sunlight, and the phenotypic characteristics of the breed are the main factors responsible for the high prevalence of SCC, showing the susceptibility of the Friesian Milchschaf breed and crossbreed in temperate zones as Uruguay.
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Chessa, Marco A., Annalisa Patrizi, Carlotta Baraldi, Pier Alessandro Fanti, Alessia Barisani y Sabina Vaccari. "Dermoscopic–Histopathological Correlation of Eccrine Poroma: An Observational Study". Dermatology Practical & Conceptual, 24 de septiembre de 2019, 283–91. http://dx.doi.org/10.5826/dpc.0904a07.
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Background: Eccrine poroma (EP) is a benign adnexal neoplasm that can be pigmented in 17% of cases. Four histopathological variants of EP exist. Dermoscopically, EP can mimic many other skin neoplasms.
Objectives: To provide a dermoscopic–histopathological correlation of EP, classifying the clinical and dermoscopic features of EPs on the basis of their histopathological subtype, in an attempt to better characterize these entities.
Patients and Methods: A single-center retrospective study was conducted. Clinical data were collected; patients were classified on the basis of the 4 histopathological variants of EPs. Dermoscopic images were reviewed. A dermoscopic–histopathological correlation was performed, and the results were compared with literature data.
Results: Twenty-six lesions were included, both pigmented and nonpigmented. Three of the 4 histopathological variants were identified. Different dermoscopic features were observed for each distinct histopathological subtype of EP. The lesions mimicked different types of other skin neoplasms, in particular: nonpigmented hidroacanthoma simplex resembled nonmelanoma skin cancer; pigmented hidroacanthoma simplex appeared like a seborrheic keratosis or a solar lentigo; EPs sensu stricto presented as pink nodules if nonpigmented and were similar to seborrheic keratosis if pigmented; dermal duct tumors appeared as pigmented nodular lesions.
Conclusions: Distinct dermoscopic features appeared to be recurrent in each histopathological variant. Dermoscopy can provide important clues for the diagnosis of EP; the final diagnosis is allowed by histopathology. To achieve a correct diagnosis of EP, because of its clinical and dermoscopic variability, surgical excision is recommended.
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Bánvölgyi, A., A. Görög, K. Gadó y P. Holló. "Common benign and malignant tumours of the aging skin: Characteristics and treatment options". Developments in Health Sciences, 1 de junio de 2022. http://dx.doi.org/10.1556/2066.2022.00055.
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Abstract The incidence of all types of malignant skin tumours, including both melanoma and non-melanoma types, has increased in recent decades, while basal cell carcinoma is the most common human malignancy in the Caucasian race. The aging of the skin is associated with an increase in both benign and malignant tumours. As the population ages and life expectancy extends, mostly in developed countries, dermatologists are likely to face growing numbers of patients seeking therapy for such abnormalities. It is primarily UV irradiation that is responsible for the development of skin cancers, although there are other risk factors, including air pollution and X-ray irradiation. Seborrhoeic keratosis, solar lentigo and other benign lesions, despite their harmless nature, may cause distress to patients, such as itching or aesthetic issues. This review article summarises the features of the most common benign and malignant lesions of aging skin.