Literatura académica sobre el tema "SmORF peptide"
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Artículos de revistas sobre el tema "SmORF peptide"
Markus, Damien, Aurore Pelletier, Muriel Boube, Fillip Port, Michael Boutros, François Payre, Benedikt Obermayer y Jennifer Zanet. "The pleiotropic functions of Pri smORF peptides synchronize leg development regulators". PLOS Genetics 19, n.º 10 (30 de octubre de 2023): e1011004. http://dx.doi.org/10.1371/journal.pgen.1011004.
Texto completoLyapina, Irina, Vadim Ivanov y Igor Fesenko. "Peptidome: Chaos or Inevitability". International Journal of Molecular Sciences 22, n.º 23 (4 de diciembre de 2021): 13128. http://dx.doi.org/10.3390/ijms222313128.
Texto completoDouka, Katerina, Isabel Birds, Dapeng Wang, Andreas Kosteletos, Sophie Clayton, Abigail Byford, Elton J. R. Vasconcelos et al. "Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation". RNA 27, n.º 9 (30 de junio de 2021): 1082–101. http://dx.doi.org/10.1261/rna.078782.121.
Texto completoBonilauri, Bernardo, Fabiola Barbieri Holetz y Bruno Dallagiovanna. "Long Non-Coding RNAs Associated with Ribosomes in Human Adipose-Derived Stem Cells: From RNAs to Microproteins". Biomolecules 11, n.º 11 (11 de noviembre de 2021): 1673. http://dx.doi.org/10.3390/biom11111673.
Texto completoDozier, Christine, Audrey Montigny, Mireia Viladrich, Raphael Culerrier, Jean-Philippe Combier, Arnaud Besson y Serge Plaza. "Small ORFs as New Regulators of Pri-miRNAs and miRNAs Expression in Human and Drosophila". International Journal of Molecular Sciences 23, n.º 10 (20 de mayo de 2022): 5764. http://dx.doi.org/10.3390/ijms23105764.
Texto completoSouthan, Christopher. "Last rolls of the yoyo: Assessing the human canonical protein count". F1000Research 6 (7 de abril de 2017): 448. http://dx.doi.org/10.12688/f1000research.11119.1.
Texto completoWan, Linrong, Wenfu Xiao, Ziyan Huang, Anlian Zhou, Yaming Jiang, Bangxing Zou, Binbin Liu, Cao Deng y Youhong Zhang. "Systematic identification of smORFs in domestic silkworm (Bombyx mori)". PeerJ 11 (13 de enero de 2023): e14682. http://dx.doi.org/10.7717/peerj.14682.
Texto completoCao, Yipeng, Rui Yang, Imshik Lee, Wenwen Zhang, Jiana Sun, Xiangfei Meng y Wei Wang. "Prediction of LncRNA-encoded small peptides in glioma and oligomer channel functional analysis using in silico approaches". PLOS ONE 16, n.º 3 (18 de marzo de 2021): e0248634. http://dx.doi.org/10.1371/journal.pone.0248634.
Texto completoMagny, Emile G., Jose Ignacio Pueyo, Frances M. G. Pearl, Miguel Angel Cespedes, Jeremy E. Niven, Sarah A. Bishop y Juan Pablo Couso. "Conserved Regulation of Cardiac Calcium Uptake by Peptides Encoded in Small Open Reading Frames". Science 341, n.º 6150 (22 de agosto de 2013): 1116–20. http://dx.doi.org/10.1126/science.1238802.
Texto completoDragomir, Mihnea P., Ganiraju C. Manyam, Leonie Florence Ott, Léa Berland, Erik Knutsen, Cristina Ivan, Leonard Lipovich, Bradley M. Broom y George A. Calin. "FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs". Non-Coding RNA 6, n.º 4 (23 de septiembre de 2020): 41. http://dx.doi.org/10.3390/ncrna6040041.
Texto completoTesis sobre el tema "SmORF peptide"
Pelletier, Aurore. "Fonctions des peptides smORF Tic-Tac et Sem1 dans la reproduction et le développement chez la Drosophile". Electronic Thesis or Diss., Toulouse 3, 2023. http://www.theses.fr/2023TOU30269.
Texto completoRecent technological advances have revealed that small ORFs (Open Reading Frame), which are less than 100 codons in size and were previously considered non-coding due to their small size, can be translated into thousands of smORF (small ORF) peptides in all organisms. Several studies have shown that smORF peptides can interact with canonical proteins and regulate their activity. Thus, the smORF peptide family represents a vast unexplored reservoir of potential regulators. A functional screen carried out in Drosophila identified new smORF peptides involved in development, several of which are derived from polycistronic RNA translation. My thesis research project was to characterize the function in Drosophila of 1) Tic and Tac, two unknown smORF peptides encoded by a bicistronic RNA, and 2) Sem1/DSS1, a highly conserved peptide. The first part of my thesis was to analyze the biological function of two unknown smORF peptides encoded by a bicistronic RNA that we named tictac. I demonstrated that Tic and Tac are two peptides translated from the same bicistronic RNA tictac, but with different AA sequences and cellular localization. In vivo, tictac is highly expressed in male reproductive organs. Following mating, behavioral and physiological changes characterizing the post-mating response in female, which are mainly induced by the seminal fluid, are affected in the absence of tictac in males. Using transcriptome analysis on male reproductive organs, I show that the absence of tictac leads to transcriptional deregulation of 150 genes. Among them, 10% code for seminal fluid components, proving that tictac regulates its composition. Specific deletion of either tic or tac highlights that they have different in vivo functions, but that both are involved in seminal fluid synthesis. The analysis of accessory glands, the functional seminal fluid-producing organ equivalent to the human prostate, reveals that their maturation and secretory function are regulated by tictac. The search for homologs of Tic and Tac indicates that Tic has a peptide domain with strong homology to a subdomain of RQC1, a yeast protein involved in ribosome quality control, and Tac has a serglycin domain, known in human to have important functions in secretion. My data therefore suggests that Tic and Tac smORF peptides may contribute to the synthesis and secretion of seminal fluid proteins. In a second step, I carried out the molecular analysis of Sem1, an intrinsically disordered protein known to interact with and regulate several macromolecular complexes. As these data were only generated in cellulo and in vitro models, I carried out the molecular analysis of Sem1 for the first time in vivo. I showed that Sem1 is essential, as its deletion induces lethality at the larval stage. Moreover, its absence leads to massive apoptosis that generalizes to the whole tissue in a non-cell-autonomous manner. To uncouple the molecular functions of Sem1 and identify the protein domains essential for cell survival, I generated a mutated form of each functional domain, then induced its expression in the absence of endogenous Sem1. This structure-function analysis revealed that two domains known to interact with ubiquitin are essential for development. In conclusion, my thesis work highlights new functions of smORF peptides in reproduction and cell survival, illustrating the ability of smORF peptides to act on multiple macro-molecular complexes, thus controlling numerous physiological processes