Artículos de revistas: "Small-size PTC"

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LI, Jia-wei, Cai Chang, Jia-ying Chen, Zhao-ting Shi y Min Chen. "Nodule Size Effect on Diagnostic Performance of Ultrasonography and Computed Tomography for Papillary Thyroid Carcinoma". Current Medical Imaging Formerly Current Medical Imaging Reviews 15, n.º 5 (19 de junio de 2019): 489–95. http://dx.doi.org/10.2174/1573405614666180425142141.

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Background: To compare the abilities of ultrasonography (US) and Computed Tomography (CT) to identify calcifications and to predict probability of malignancy for Papillary Thyroid Carcinoma (PTC) and Papillary Thyroid Microcarcinoma (PTMC). Methods: We reviewed 1008 cases of PTC/PTMC with calcifications reported by pre-operative US, CT, or post-operative pathology. The size of the thyroid nodule was obtained from the US report and the maximum diameter (d) was documented. According to the nodule size (d), the PTC and PTMC groups were each divided into two subgroups, as follows: large PTC group (d ≥ 2 cm), small PTC group (1 cm < d < 2 cm), large PTMC group (0.6 cm ≤ d ≤ 1 cm), and small PTMC group (d < 0.6 cm). Results: In the 1008 patients, the ratio of females to males was 2.29 and the mean age was 40.9 years (standard deviation: 11.7 years). Of the 1008 records, 92.8% were found to have calcifications according to the US report, while 50.4% showed calcifications according to the CT report. This difference between US and CT reports was statistically significant (p < 0.0005). The percentages of US reports showing calcifications were similar for all four PTC and PTMC subgroups (93.7%, 94.3%, 92.1%, and 85.1%, respectively; p = 0.052), while the percentages of CT reports showing calcifications were significantly different among the PTC and PTMC subgroups (62.3%, 52.2%, 45.4%, and 31.3%, respectively; p < 0.0005). As for the prediction of malignancy, US was superior to CT in all four subgroups (large PTC group: 97.1% vs. 54.1%, small PTC group: 94.8% vs. 42.9%, large PTMC group: 97.2% vs. 32.0%, small PTMC group: 95.5% vs. 14.9%; p < 0.0005 for all pairwise comparisons). No significant difference was observed in terms of the ability of US to predict the malignancy of PTC versus PTMC (p = 0.31), while CT showed significant superiority in diagnosing PTC versus PTMC (p < 0.0005). The predictive value of CT for PTC declined as the nodule size decreased (p < 0.05 for all pairwise comparisons). Conclusion: Our results showed that US detected calcifications and predicted the malignancy of all nodule sizes of thyroid papillary carcinoma equally well, while the performance of CT declined with the reduction of nodule size.

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Dai, Daofeng, Yawen Tan, Liangfeng Guo, Aifa Tang y Yongsheng Zhao. "Identification of exosomal miRNA biomarkers for diagnosis of papillary thyroid cancer by small RNA sequencing". European Journal of Endocrinology 182, n.º 1 (enero de 2020): 111–21. http://dx.doi.org/10.1530/eje-19-0524.

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Context Exosomal miRNAs are considered potential non-invasive biomarkers for thyroid cancer. However, the global exosomal miRNAs profile for papillary thyroid cancer (PTC) has not been revealed. Objective This study investigated the diagnostic value of plasma and serum exosomal miRNAs for PTC. Methods Plasma and serum samples were collected from ten patients with benign thyroid nodules and 17 with PTC for small RNA sequencing. Plasma samples were collected from two independent cohorts, including 119 patients with PTC, 51 healthy people and 82 patients with benign thyroid nodules, for validation by quantitative reverse-transcription polymerase chain reaction (RT-qPCR). Results Small RNA sequencing identified 41 putative exosomal miRNA biomarkers for PTC. Twelve miRNAs were selected for validation. miR-376a-3p, miR-4306, miR-4433a-5p, and miR-485-3p expression significantly increased in patients with PTC compared to that in healthy people and patients with benign thyroid nodules (P ˂ 0.05). Moreover, miR-485-3p and miR-4433a-5p presented larger areas under the curve (AUCs). The high expression of exosomal miR-485-3p correlated with tumor size greater than or equal to 1 cm, advanced clinical stage, extrathyroidal extension, BRAF mutation, and lymph node metastasis. Besides, miR-485-3p exhibited the highest AUCs in diagnosing PTC patients with high-risk factors. Conclusions Plasma exosomal miR-485-3p and miR-4433a-5p might serve as biomarkers for PTC diagnosis. Plasma exosomal miR-485-3p could enable discrimination between high-risk and low-risk PTC.

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Rodrigues, Evaldo Almeida y Sílvio Albergaria. "Avaliação da capacidade de remoção da camada residual dentinária com o uso do Endo PTC em diferentes formulações, associado a duas concentrações de hipoclorito de sódio, utilizando-se ou não irrigação final com EDTA". Revista de Ciências Médicas e Biológicas 10, n.º 1 (12 de julio de 2011): 44. http://dx.doi.org/10.9771/cmbio.v10i1.4932.

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Resumo A ação dos instrumentos nas paredes do canal radicular proporciona a formação da camada residual dentinária que, quando não é removida, pode interferir no selamento almejado na etapa da obturação. Algumas substâncias químicas com diferentes composições e variadas concentrações são utilizadas, isoladas ou em associações, para remover essa camada residual. O presente estudo buscou analisar in vitro, através de Microscopia Eletrônica de Varredura, a eficácia, na remoção da camada residual dentinária, de diferentes formulações de Endo PTC, quando associadas a diferentes concentrações de hipoclorito de sódio, utilizando-se ou não irrigação final com EDTA. Foram utilizados oitenta dentes unirradiculares humanos recém-extraídos, divididos aleatoriamente, da seguinte maneira: Grupo I – preparo do canal com Endo PTC creme, associado ao hipoclorito sódio a 1%; Grupo II – preparo do canal como Endo PTC creme, associado ao hipoclorito de sódio a 2,5%; Grupo III – preparo do canal com Endo PTC creme associado ao hipoclorito de sódio a 1% e irrigação final com EDTA a 17%; Grupo IV – preparo do canal com Endo PTC creme associado ao hipoclorito de sódio a 2,5 e irrigação final com EDTA a 17%. Nos Grupos V, VI, VII e VIII foram utilizadas as mesmas substâncias dos grupos I, II, III e IV, respectivamente, substituindo-se o Endo PTC creme pelo Endo PTC Leve. Os resultados mostraram que a irrigação final com EDTA promove uma melhor remoção da camada residual, independentemente da concentração do hipoclorito de sódio e da formulação do Endo PTC.

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Ritter, Amit, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon y Eyal Robenshtok. "Natural History of Contralateral Nodules After Lobectomy in Patients With Papillary Thyroid Carcinoma". Journal of Clinical Endocrinology & Metabolism 103, n.º 2 (12 de diciembre de 2017): 407–14. http://dx.doi.org/10.1210/jc.2017-01616.

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Abstract Background Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC). However, the natural history and outcome of contralateral nodules have never been studied. Objective To investigate the natural history of nonsuspicious contralateral nodules after lobectomy for PTC. Methods We included patients who had one or more solid nodules (≥3 mm) in the contralateral lobe with benign cytology before surgery or small nonsuspicious nodules per ultrasonography. Results One hundred and twelve patients were included. Median age was 57 years, and median size of the PTC (initial lobectomy) was 8 mm (range, 0.5 to 28 mm). On the contralateral side, the median size of nodules was 7 mm (range, 3 to 30 mm). Thirty-three nodules (29%) had fine-needle aspiration (FNA) before surgery, and all were benign. After a median follow-up of 6 years, median growth was zero (range, −20 to 19 mm). Twenty-six nodules (23%) increased ≥3 mm in size (median, 6 mm; range, 4 to 19 mm). Twenty patients (18%) developed new nodules. Twelve patients (11%) underwent completion thyroidectomy for growth (three), suspicious FNA (seven; Bethesda III to V), malignancy (one), or unknown reason (one). Overall, according to the completion thyroidectomy specimen, six patients (5%) were diagnosed with contralateral PTC (five micro-PTCs, one 20 mm), and all were without evidence of disease at the end of follow-up. There were no surgical difficulties or local complications during completion surgery. Conclusions Lobectomy for low-risk patients with a small PTC and nonsuspicious contralateral thyroid nodule(s) is a reliable and safe initial treatment option. In the few patients who required completion thyroidectomy, treatment with surgery and radioiodine was effective.

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Hurmuz, Pervin, Mustafa Cengiz, Gokhan Ozyigit, Ebru Atasever Akkas, Deniz Yuce, Melek Tugce Yilmaz, Demet Yildiz, Faruk Zorlu y Fadil Akyol. "Stereotactic body radiotherapy in patients with early-stage non-small cell lung cancer: Does beam-on time matter?" Japanese Journal of Clinical Oncology 50, n.º 10 (16 de junio de 2020): 1182–87. http://dx.doi.org/10.1093/jjco/hyaa093.

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Abstract Purpose Stereotactic body radiotherapy (SBRT) is an effective treatment option for patients with early-stage non-small cell lung cancer (NSCLC). In this study, we evaluated the treatment results using two different SBRT techniques and the effect of beam-on time (BOT) on treatment outcomes. Methods Between July 2007 and January 2018, 142 patients underwent SBRT for primary NSCLC. We have delivered SBRT using either respiratory tracking system (RTS) or internal-target-volume (ITV)-based motion management techniques. The effect of age, tumor size, pretreatment tumor SUVmax value, presence of tissue diagnosis, histopathological subtype, operability status, tumor location, motion management technique, BED10 value, BOT on overall survival (OS), loco-regional control (LRC), event-free survival (EFS) and primary tumor control (PTC) were evaluated. Results Median age of the patients was 70 years (range, 39–91 years). Most of the patients were inoperable (90%) at the time of SBRT. Median BED10 value was 112.5 Gy. With a median follow-up of 25 months, PTC was achieved in 91.5% of the patients. Two-year estimated OS, LRC, PTC and EFS rates were 68, 63, 63 and 53%, respectively. For the entire group, OS was associated with BOT (P = 0.027), and EFS was associated with BOT (P = 0.027) and tumor size (P = 0.015). For RTS group, OS was associated with age (P = 0.016), EFS with BOT (P = 0.05) and tumor size (P = 0.024), LRC with BOT (P = 0.008) and PTC with BOT (P = 0.028). The treatment was well tolerated in general. Conclusion SBRT is an effective and safe treatment with high OS, LRC, EFS and PTC rates in patients with primary NSCLC. Protracted BOT might deteriorate SBRT outcomes.

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Bayadsi, Haytham, Martin Bergman, Malin Sund y Joakim Hennings. "Invasiveness and Metastatic Aggressiveness in Small Differentiated Thyroid Cancers: Demography of Small Papillary Thyroid Carcinomas in the Swedish Population". World Journal of Surgery 44, n.º 2 (13 de diciembre de 2019): 461–68. http://dx.doi.org/10.1007/s00268-019-05312-4.

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Abstract Background The western world is seeing a rising incidence of thyroid cancer. Improved diagnostic methods do not entirely explain this increase. Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Small PTC (≤20 mm) and especially papillary thyroid microcarcinomas (PTMC ≤10 mm) are considered to be low-risk tumors but some cases are considerably more aggressive. Sufficient understanding of these mechanisms is a long-term goal for more efficient and safer treatment of these tumors. Methods We identified 959 cases of small PTCs in the validated Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery, grouped according to lymph node metastasis. These were analyzed according to age, gender, tumor size and geographic region. Results Patients with N1b disease (lateral lymph nodes metastases) had a smaller tumor size compared to patients with N1a disease (8.6 mm vs 10.1 mm respectively, p < 0.05). Patients and specifically females with N1b disease were younger than those with N0 or N1a disease. Patients with N1b disease had a lower proportion of females (60%) compared to N0 and N1a groups (81% and 78%, respectively). The incidence of operated small PTCs and of lymph node engagement differs between geographic regions in Sweden. Conclusions Small PTC and especially PTMC seem to show different patterns of aggressiveness and demography regarding lateral lymph node metastases and 7% had N1b disease and tumor <1 cm, underscoring the importance of lymph node evaluation in PTMC patients. More understanding of predictive factors, mechanisms for metastatic disease and causes of regional differences, is needed.

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Lang, Brian Hung-Hin, Young Jun Chai, Benjamin J. Cowling, Hye Sook Min, Kyu Eun Lee y Yeo-Kyu Youn. "Is BRAFV600E mutation a marker for central nodal metastasis in small papillary thyroid carcinoma?" Endocrine-Related Cancer 21, n.º 2 (8 de enero de 2014): 285–95. http://dx.doi.org/10.1530/erc-13-0291.

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Utilizing BRAFV600E mutation as a marker may reduce unnecessary prophylactic central neck dissection (pCND) in clinically nodal negative (cN0) neck for small (≤2 cm) classical papillary thyroid carcinoma (PTC). We aimed to assess whether BRAF is a significant independent predictor of occult central nodal metastasis (CNM) and its contribution to the overall prediction after adjusting for other significant preoperative clinical factors in small PTC. Primary tumor tissue (paraffin-embedded) from 845 patients with small classical cN0 PTC who underwent pCND was tested for BRAF mutation. Clinicopathologic factors were compared between those with and without BRAF. BRAF was evaluated to see if it was an independent factor for CNM. Prediction scores were generated using logistic regression models and their predictability was measured by the area under the ROC curve (AUC). The prevalence of BRAF was 628/845 (74.3%) while the rate of CNM was 285/845 (33.7%). Male sex (odds ratio (OR): 2.68, 95% CI: 1.71–4.20), large tumor size (OR: 2.68, 95% CI: 1.80–4.00), multifocality (OR: 1.49, 95% CI: 1.07–2.09), lymphovascular permeation (OR: 10.40, 95% CI: 5.18–20.88), and BRAF (OR: 1.65, 95% CI: 1.10–2.46) were significant independent predictors of CNM, while coexisting Hashimoto's thyroiditis (OR: 0.56, 95% CI: 0.40–0.80) was an independent protective factor. The AUC for prediction score based on tumor size and male sex was similar to that of prediction score based on tumor size, male sex, and BRAF status (0.68 vs 0.69, P=0.60). Although BRAF was an independent predictor of CNM, knowing its status did not substantially improve the overall prediction. A simpler prediction score based on male sex and tumor size might be sufficient.

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Ryu, Young-Jae, Seong-Young Kwon, Soo-Young Lim, Yong-Min Na y Min-Ho Park. "Predictive Factors for Skip Lymph Node Metastasis and Their Implication on Recurrence in Papillary Thyroid Carcinoma". Biomedicines 10, n.º 1 (16 de enero de 2022): 179. http://dx.doi.org/10.3390/biomedicines10010179.

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Skip lymph node (LN) metastases in papillary thyroid carcinoma (PTC) belong to N1b classification in the absence of central neck LN involvement. This study aimed to evaluate the predictive factors of skip metastases and their impact on recurrence in PTC patients with pN1b. A total of 334 PTC patients who underwent total thyroidectomy with LN dissection (central and lateral neck compartment) followed by radioactive iodine ablation were included. Patients with skip metastases tended to have a small primary tumor (≤1 cm) and single lateral neck level involvement. Tumor size ≤ 1 cm was an important predictive factor for skip metastases. Univariate analysis for recurrence showed that patients with a central LN ratio > 0.68, lateral LN ratio > 0.21, and stimulated thyroglobulin (Tg) levels > 7.3 ng/mL had shorter RFS (recurrence-free survival). The stimulated Tg level was associated with shorter RFS on multivariate analysis (>7.3 vs. ≤7.3 ng/mL; hazard ratio, 4.226; 95% confidence interval, 2.226−8.022; p < 0.001). Although patients with skip metastases tended to have a small primary tumor and lower burden of lateral neck LN involvement, there was no association between skip metastases and RFS in PTC with pN1b. Stimulated Tg level was a strong predictor of recurrence.

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Conway, Jessica M. y Alan S. Perelson. "Post-treatment control of HIV infection". Proceedings of the National Academy of Sciences 112, n.º 17 (13 de abril de 2015): 5467–72. http://dx.doi.org/10.1073/pnas.1419162112.

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Antiretroviral therapy (ART) for HIV is not a cure. However, recent studies suggest that ART, initiated early during primary infection, may induce post-treatment control (PTC) of HIV infection with HIV RNA maintained at <50 copies per mL. We investigate the hypothesis that ART initiated early during primary infection permits PTC by limiting the size of the latent reservoir, which, if small enough at treatment termination, may allow the adaptive immune response to prevent viral rebound (VR) and control infection. We use a mathematical model of within host HIV dynamics to capture interactions among target cells, productively infected cells, latently infected cells, virus, and cytotoxic T lymphocytes (CTLs). Analysis of our model reveals a range in CTL response strengths where a patient may show either VR or PTC, depending on the size of the latent reservoir at treatment termination. Below this range, patients will always rebound, whereas above this range, patients are predicted to behave like elite controllers. Using data on latent reservoir sizes in patients treated during primary infection, we also predict population-level VR times for noncontrollers consistent with observations.

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Ognerubov, N. A. y T. S. Antipova. "Metastases of papillary radioiodine-refractory thyroid cancer in the parapharyngeal lymph node: clinical case". Head and Neck Tumors (HNT) 11, n.º 1 (24 de abril de 2021): 115–21. http://dx.doi.org/10.17650/2222-1468-2021-11-1-115-121.

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Introduction. Papillary thyroid cancer (PTC) usually metastasizes into the central and lateral lymph nodes (LNs) of the neck. Metastases into the retropharyngeal and parapharyngeal LNs are rare. Their presence attests to aggressive PTC.The study objective is to describe a rare case of metastases of papillary radioiodine-refractory PTC into the parapharyngeal LN.Clinical case. In 2015, female patient K., 40 years old, underwent thyroidectomy due to PTC. Histological examination verified papillary PTC with growth through the capsule and ingrowth into the surrounding tissues and muscles. In a separately admitted LN, metastases of the same cancer were observed. One year later, regional metastases in the lateral neck LNs were detected. Radioiodine therapy (activity 131I 4.5 GBq) was performed followed by fascial circular section of the neck tissues on the right per thyroid type. Morphological examination verified presence of papillary PTC metastases in 4 LNs. In January of 2018, positron emission tomography showed metastases in the paratracheal LNs. Central neck lymph node dissection was performed. Per histological conclusion, fat tissue and LN contained multiple metastases of papillary PTC. In October of the same year, repeat radioiodine therapy (activity 131I 3.0 GBq) was performed. Thyroglobulin levels increased. In June of 2020, repeat positron emission tomography showed a single metastasis in the parapharyngeal LN. Due to small size of the metastasis and absence of signs of progression, dynamic follow-up and hormone therapy were suggested to the patient.Conclusion. Metastatic involvement of parapharyngeal LNs is rare, especially in radioiodine-refractory PTC. They can be detected both during primary diagnosis and after the treatment during dynamic follow-up, as well as a single manifestation of PTC, which should be taken into account during differential diagnosis.

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MA, Islam, Mohammed T, Mamoon TB, Chowdhury NH, Khan SR y Rahman ASML. "Hemithyroidectomy: Papillary Thyroid Carcinoma in Low Risk Group Patients". International Journal of Innovative Science and Research Technology 5, n.º 6 (27 de junio de 2020): 376–80. http://dx.doi.org/10.38124/ijisrt20jun411.

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Papillary thyroid cancer (PTC) is the most prevalent histologic subtype of thyroid cancer accounting for more than 80% of all cases. A single size threshold of 4 cm maximized prognostic discrimination with tumors >4 cm associated with a five times higher risk of recurrence than those ≤4 cm. The purpose of this present study was to determine an effective treatment strategy for patients with small unilateral papillary thyroid carcinoma in a low risk group below tumor size ≤ 4 cm.

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Cheng, Shih-Min, Kevin Qu, Adam Abdool, Anthony Sferruzza, Frederic Waldman y Richard E. Reitz. "A molecular diagnostic panel for thyroid cancer disease management." Journal of Clinical Oncology 30, n.º 15_suppl (20 de mayo de 2012): 5510. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.5510.

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5510 Background: In 2009, the American Thyroid Association revised its guidelines for patients with thyroid nodules and differentiated thyroid cancers, recommending BRAF, RAS, RET/PTC, and PAX8-PPARγ molecular testing in patients with indeterminate fine-needle aspirate (FNA) cytology. Alterations in any of these markers in thyroid nodules are strongly associated with malignancy. We studied the prevalence of these alterations in thyroid FNA specimens in order to establish a strategy to improve disease management. Methods: DNA and RNA were extracted from thyroid FNA specimens (N=149) and tested for BRAF mutations using allele-specific PCR (V600E and K601E); for RAS (H-, K-, N-) mutations using pyrosequencing (codons 12, 13, and 61); and for RET/PTC1 and RET/PTC3 rearrangements and PAX8-PPARγ translocations using RT-PCR. Results: Overall, 90 (60.4%) of the specimens had alterations in ≥1 of the 4 molecular markers (Table). BRAF V600E mutations (54.4%) were the most prevalent mutations in papillary thyroid cancer (PTC); no K601E mutations were found. RAS mutations were found in PTC, follicular adenoma (FA), and follicular thyroid cancer (FTC) specimens; half of these mutations involved N-RAS Q61. RET/PTC rearrangements were detected in 3.5% of PTC specimens and were evenly distributed between the 2 major subtypes, RET/PTC1 and RET/PTC3. PAX8/PPARγ translocations were detected in 18.8% of FTC but not in FA, probably due to small sample size. Out of 7 indeterminate thyroid nodules, 2 had BRAF mutations and 2 had RAS mutations. The presence of the 4 markers was generally mutually exclusive; only 1 PTC specimen had concurrent RAS and RET/PTC1 alterations. Conclusions: The prevalence of BRAF, RAS, RET/PTC, and PAX8/PPARγ alterations in thyroid cancer specimens highlights the potential for targeted therapeutic strategies. The mutually exclusive pattern of alterations also suggests a hierarchical screening strategy for samples with limited availability. [Table: see text]

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Estrada-Flórez, Ana P., Mabel E. Bohórquez, Alejandro Vélez, Carlos S. Duque, Jorge H. Donado, Gilbert Mateus, Cesar Panqueba-Tarazona et al. "BRAF and TERT mutations in papillary thyroid cancer patients of Latino ancestry". Endocrine Connections 8, n.º 9 (septiembre de 2019): 1310–17. http://dx.doi.org/10.1530/ec-19-0376.

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Papillary thyroid cancer (PTC) is the second most commonly diagnosed malignancy in U.S. Latinas and in Colombian women. Studies in non-Latinos indicate that BRAF and TERT mutations are PTC prognostic markers. This study aimed to determine the prevalence and clinical associations of BRAF and TERT mutations in PTC Latino patients from Colombia. We analyzed mutations of BRAF (V600E) and TERT promoter (C228T, C250T) in tumor DNA from 141 patients (75 with classical variant PTC, CVPTC; 66 with follicular variant PTC, FVPTC) recruited through a multi-center study. Associations between mutations and clinical variables were evaluated with Fisher exact tests. Survival was evaluated with Kaplan–Meier plots. Double-mutant tumors (BRAF+/TERT+, n = 14 patients) were more common in CVPTC (P = 0.02). Relative to patients without mutations (n = 48), double mutations were more common in patients with large tumors (P = 0.03), lymph node metastasis (P = 0.01), extra-thyroid extension (P = 0.03), and advanced stage (P = 6.0 × 10−5). In older patients, TERT mutations were more frequent (mean age 51 years vs 45 years for wild type TERT, P = 0.04) and survival was lower (HR = 1.20; P = 0.017); however, given the small sample size, the decrease in survival was not statically significant between genotypes. Comparisons with published data in US whites revealed that Colombian patients had a higher prevalence of severe pathological features and of double-mutant tumors (10 vs 6%, P = 0.001). Mutations in both oncogenes show prognostic associations in Latinos from Colombia. Our study is important to advance Latino PTC precision medicine and replicates previous prognostic associations between BRAF and TERT in this population.

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Novas, Nuria, Aránzazu Fernández-García y Francisco Manzano-Agugliaro. "A Simplified Method to Avoid Shadows at Parabolic-Trough Solar Collectors Facilities". Symmetry 12, n.º 2 (13 de febrero de 2020): 278. http://dx.doi.org/10.3390/sym12020278.

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Renewable energy today is no longer just an affordable alternative, but a requirement for mitigating global environmental problems such as climate change. Among renewable energies, the use of solar energy is one of the most widespread. Concentrating Solar Power (CSP) systems, however, is not yet fully widespread despite having demonstrated great efficiency, mainly thanks to parabolic-trough collector (PTC) technology, both on a large scale and on a small scale for heating water in industry. One of the main drawbacks to this energy solution is the large size of the facilities. For this purpose, several models have been developed to avoid shadowing between the PTC lines as much as possible. In this study, the classic shadowing models between the PTC rows are reviewed. One of the major challenges is that they are studied geometrically as a fixed installation, while they are moving facilities, as they have a tracking movement of the sun. In this work, a new model is proposed to avoid shadowing by taking into account the movement of the facilities depending on their latitude. Secondly, the model is tested to an existing facility as a real case study located in southern Spain. The model is applied to the main existing installations in the northern hemisphere, thus showing the usefulness of the model for any PTC installation in the world. The shadow projected by a standard, the PTC (S) has been obtained by means of a polynomial approximation as a function of the latitude (Lat) given by S = 0.001 − Lat2 + 0.0121 − Lat + 10.9 with R2 of 99.8%. Finally, the model has been simplified to obtain in the standard case the shadows in the running time of a PTC facility.

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Salvestroni, M., G. Pierucci, F. Fagioli, A. Pourreza, M. Messeri, F. Taddei, S. Hosouli, H. Rashidi y M. De Lucia. "Design of a small size PTC: computational model for the receiver tube and validation with heat loss test". IOP Conference Series: Materials Science and Engineering 556 (19 de agosto de 2019): 012025. http://dx.doi.org/10.1088/1757-899x/556/1/012025.

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Groener, Jan, Debora Gelen, Carolin Mogler, Esther Herpel, Csaba Toth, Zoltan Kender, Marco Peichl et al. "BRAF V600E and Retinoic Acid in Radioiodine-Refractory Papillary Thyroid Cancer". Hormone and Metabolic Research 51, n.º 01 (5 de noviembre de 2018): 69–75. http://dx.doi.org/10.1055/a-0765-9078.

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AbstractRadioiodine refractoriness in differentiated thyroid cancer remains an unsolved therapeutic problem. Response to retinoids might depend on specific genetic markers. In this retrospective analysis, associations between BRAF V600E and clinical outcomes after redifferentiation with retinoic acid (RA) and radioiodine therapy (RIT) were investigated. Thirteen patients with radioiodine-refractory (RAI-R) papillary thyroid cancer (PTC) were treated with 13-cis-RA followed by iodine-131 treatment at the Department of Endocrinology, Heidelberg University Hospital, Heidelberg, Germany. DNA sequencing was performed in formalin-fixed paraffin-embedded tissue. Clinical outcome parameters were tumor size, thyroglobulin, and radioiodine uptake in correlation to mutational status. Differences of each parameter were compared before and after RA/RIT. Initial response showed no difference in patients with BRAF V600E compared to patients with wild type. However, after a median follow-up of 2 and a half years, 2 out of 3 patients with BRAF V600E showed response compared to 5 out of 9 with wild type under consideration of all 3 parameters. In this small cohort, more RAI-R PTC patients with BRAF V600E receiving redifferentiation therapy showed response. Verification in a larger study population analyzing mutational status in patients with RAI-R PTC might be helpful to identify patients where redifferentiation therapy might lead to an improved outcome.

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Robenshtok, E., S. Fish, A. Bach, Jose M. Domínguez, A. Shaha y R. M. Tuttle. "Suspicious Cervical Lymph Nodes Detected after Thyroidectomy for Papillary Thyroid Cancer Usually Remain Stable Over Years in Properly Selected Patients". Journal of Clinical Endocrinology & Metabolism 97, n.º 8 (1 de agosto de 2012): 2706–13. http://dx.doi.org/10.1210/jc.2012-1553.

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Abstract Context: The risk of loco-regional recurrence in papillary thyroid cancer (PTC) patients ranges from 15–30%. However, the clinical significance of small-volume loco-regional recurrence detected by highly sensitive ultrasonography is unclear. Objective: Our objective was to describe the natural history of abnormal cervical lymph nodes (LN) diagnosed after initial treatment. Design: We conducted a retrospective cohort study. Patients: 166 PTC with patients who had at least one abnormal LN outside the thyroid be on ultrasound and selected for active surveillance were included. Main Outcome Measure: LN growth during a period of active surveillance was the primary outcome. Results: Most patients had classical PTC (85%) and an intermediate risk of recurrence (77%). The median LN size at the start of the observation period was 1.3 cm (range, 0.5–2.7 cm) in largest diameter, with all nodes having at least one abnormal sonographic characteristic (70% of patients had LN with at least two abnormal features). In almost all patients, the LN were in the lateral neck, primarily in levels 3 (43%) and 4 (58%). After a median follow-up of 3.5 yr, only 20% (33 of 166) grew at least 3 mm, 9% (15 of 166) grew at least 5 mm, and 14% (23 of 166) resolved. None of the clinical or sonographic features were predictive of LN growth (positive predictive value range = 0.21–0.57). There were no local complications (nerve damage or local invasion) related to the abnormal nodes and no disease-related mortality. Conclusions: Suspicious cervical LN in the lateral neck usually remain stable for long periods of time in properly selected PTC patients and can be safely followed with serial ultrasounds

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Szász, Emőke-Andrea, Adela Nechifor-Boilă, Ancuța Zahan y Angela Borda. "High-risk morphological features are less prevalent among small (<5mm) papillary thyroid microcarcinomas compared to larger (≥5mm) tumors: a study of 206 cases". Acta Marisiensis - Seria Medica 67, n.º 2 (1 de junio de 2021): 108–14. http://dx.doi.org/10.2478/amma-2021-0016.

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Abstract Introduction: Papillary thyroid microcarcinoma (PTMC) is defined as a PTC measuring 1 cm or less, incidentally discovered. The aim of this study was to determine whether small (<5mm) tumors by contrast with large (≥5mm) ones are less frequently associated with high-risk morphological features, predictive of tumor aggressiveness. Materials and methods: All consecutive PTMC cases registered at the Department of Pathology, Târgu-Mureş Emergency County Hospital between 2003-2014 were reviewed. The following have been assessed: tumor size, subcapsular versus nonsubcapsular location, extrathyroidal extension/invasion into the perithyroidal adipose tissue, multifocality, resection margins, lymph node involvement, histological variant, tumor border, stromal reaction (fibrosis/desmoplasia/sclerosis), presence of plump pink cells, nuclear features of the tumor cells, intratumoral lymphocytic infiltrate, multinucleated giant cells, psammoma bodies and stromal calcification. The cases were split in two categories: small (< 5mm) and large (≥ 5mm) PTMCs and the pathological features were evaluated in comparison. Results: Our study included 206 cases, 91 large and 115 small PTMCs, respectively. Large PTMCs were significantly associated with the presence of plump pink cells (p=0.002), well developed PTC nuclear features (p=0.003), stromal reaction (fibrosis/desmoplasia/sclerosis) (p<0.001), infiltrative tumor border (p=0.011), subcapsular location (p<0.001), positive resection margins (p=0.022), stromal calcifications (p<0.001) and intratumoral multinucleated giant cells (p<0.001). Small PTMCs were generally well circumscribed and nonsubcapsular. Conclusions: Our results have shown that small (<5mm) PTMCs are less frequently associated with high-risk morphological features, predictive of tumor aggressiveness compared with large (≥5mm) tumors and could thus be considered as low-risk cancers.

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Yang, So Yeon, Jung Hee Shin, Soo Yeon Hahn, Yaeji Lim, Seok Young Hwang, Tae Hyuk Kim y Jee Soo Kim. "Comparison of ultrasonography and CT for preoperative nodal assessment of patients with papillary thyroid cancer: diagnostic performance according to primary tumor size". Acta Radiologica 61, n.º 1 (13 de mayo de 2019): 21–27. http://dx.doi.org/10.1177/0284185119847677.

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Background Indications for computed tomography (CT) in preoperative patients with thyroid cancer are still controversial. Purpose To determine the value of CT and ultrasonography (US) in preoperative lymph node assessment of patients with papillary thyroid carcinoma (PTC) according to primary tumor size. Material and Methods A total 453 patients with surgically proven PTC who underwent US and CT for preoperative evaluation in 2010 at our tertiary referral center were included. The diagnostic sensitivity, specificity, and accuracy of US, CT, and the combination of US and CT (US/CT) in the preoperative nodal assessment were compared. We performed subgroup analysis to compare the findings according to primary tumor size. Results In overall tumors, adding CT to US had greater sensitivity, lower specificity, and greater accuracy in predicting central lymph node metastasis (LNM) but lower accuracy in prediction of lateral LNM. In smaller cancers (≤1 cm), US alone had greater specificity and accuracy than CT alone or US/CT in predicting lateral LNM. In larger cancers (>1 cm), CT had greater sensitivity and accuracy than US in predicting central LNM, while US had greater specificity and accuracy than CT in predicting lateral LNM. There were no patients with smaller tumors who showed retropharyngeal and superior mediastinal LNM diagnosed by CT alone. Conclusion CT is superior to US for detecting central LNM in preoperative patients with PTCs > 1 cm. However, there are no benefits to adding CT to US to predict lateral LNM in small cancers (≤1 cm).

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Begum, Fatima, Sadia Sultana, Nabeel Fahmi Ali, Mohshi Um Mokaddema y Nurun Nahar. "Papillary Thyroid Carcinoma Presented with Huge Bone Metastases Right Ileum and Frontal Bones". Bangladesh Journal of Nuclear Medicine 17, n.º 1 (10 de marzo de 2015): 125–32. http://dx.doi.org/10.3329/bjnm.v17i1.22504.

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Papillary thyroid carcinoma (PTC) without metastases is most curable cancer. However, it rarely metastasizes to bone and in those cases prognosis is poor. A 55 years old female has presented with history of painless swelling on frontal region of skull for one year and limping gait to National Institute of Nuclear Medicine and Allied Sciences (NINMAS) in September 2013. She also had total thyroidectomy for multinodular goiter in early 2013. She had history of excision of swelling on frontal region in July of same year. Histopathological report of excised mass confirmed metastatic PTC. The patient again developed visible swelling on frontal region of skull suggesting recurrence. Her serum TSH was low 0.89 mIU/L without levothyroxine supplement may be due to thyroid hormones produced from metastatic masses. Serum thyroglobulin level was 464 ng/ml. X-ray of pelvis and skull showed huge soft tissue masses arising from right ileum and a lytic lesion on posterior aspect of frontal region. Whole body bone scan with 99m Technetium methylene diphosphonate (MDP) revealed a doughnut lesion of frontal bone and a big lesion with hot and cold areas in right ileum and. On ultrasound scan, there was huge solid mass (about 10.0 cm× 7.0 cm) with some inhomogeneity and central cystic changes in medial aspect of right hip bone extending to pelvic cavity. Similar mass corresponded the visible swelling on skull. This mass was extended to intracranial region. Color Doppler study showed vascularity within and at margins of masses. To avoid risk of raised intracranial pressure following radioiodine therapy we sent the patient for external beam radiation therapy (EBRT) for reduction of the size of masses. Patient under went 5 cycles of EBRT (total 2000 c Gy in each lesion) but there were no reductions of sizes within one month follow up period. Small bony metastatic lesions from PTC in early stage are curable by surgical removal and repeated dose of radioiodine therapy. PTC with multiple advanced bony metastases shows poor prognosis. DOI: http://dx.doi.org/10.3329/bjnm.v17i1.22504 Bangladesh J. Nuclear Med. 17(1): 125-132, January 2014

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Piccardo, Arnoldo, Francesco Fiz, Gianluca Bottoni, Camilla De Luca, Michela Massollo, Ugo Catrambone, Luca Foppiani, Monica Muraca, Alberto Garaventa y Pierpaolo Trimboli. "Facing Thyroid Nodules in Paediatric Patients Previously Treated with Radiotherapy for Non-Thyroidal Cancers: Are Adult Ultrasound Risk Stratification Systems Reliable?" Cancers 13, n.º 18 (18 de septiembre de 2021): 4692. http://dx.doi.org/10.3390/cancers13184692.

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Thyroid nodule ultrasound-based risk stratification systems (US-RSSs) have been successfully used in adults to predict the likelihood of malignancies. However, their applicability to the paediatric population is unclear, especially in children with a history of radiation exposure, who are at a higher cancer risk. We tested the efficacy of three US-RSSs in this setting by retrospectively applying three classification systems (ACR-TIRADS, ATA and EU-TIRADS) to all paediatric patients referred for thyroid nodules and with a radiation exposure history. We compared the results with a reference standard (pathology or 36-month follow-up); sensitivity, specificity, positive and negative predictive values (PPV and NPV) and accuracy were calculated. A total of 52 patients were included; fourteen of them (27%) had papillary thyroid cancer (PTC) at the final histology. No significant differences across the US-RSSs were detected; specificity (range 95–97%) and NPV (range 88–93%) were particularly elevated. However, ACR-TIRADS, ATA and EU-TIRADS did not indicate the need for a biopsy in six (42.8%), seven (50%) and eight (57%) cases of PTC; in five cases, this lack of indication was due to a small (<1 cm) nodule size. In conclusion, US-RSSs show a high NPV and specificity in paediatric patients, whereas the cytology indication could be improved by reconsidering the dimensional criterion.

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Schwarzer, Roland, Andrea Gramatica y Warner C. Greene. "Reduce and Control: A Combinatorial Strategy for Achieving Sustained HIV Remissions in the Absence of Antiretroviral Therapy". Viruses 12, n.º 2 (8 de febrero de 2020): 188. http://dx.doi.org/10.3390/v12020188.

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Human immunodeficiency virus (HIV-1) indefinitely persists, despite effective antiretroviral therapy (ART), within a small pool of latently infected cells. These cells often display markers of immunologic memory and harbor both replication-competent and -incompetent proviruses at approximately a 1:100 ratio. Although complete HIV eradication is a highly desirable goal, this likely represents a bridge too far for our current and foreseeable technologies. A more tractable goal involves engineering a sustained viral remission in the absence of ART––a “functional cure.” In this setting, HIV remains detectable during remission, but the size of the reservoir is small and the residual virus is effectively controlled by an engineered immune response or other intervention. Biological precedence for such an approach is found in the post-treatment controllers (PTCs), a rare group of HIV-infected individuals who, following ART withdrawal, do not experience viral rebound. PTCs are characterized by a small reservoir, greatly reduced inflammation, and the presence of a poorly understood immune response that limits viral rebound. Our goal is to devise a safe and effective means for replicating durable post-treatment control on a global scale. This requires devising methods to reduce the size of the reservoir and to control replication of this residual virus. In the following sections, we will review many of the approaches and tools that likely will be important for implementing such a “reduce and control” strategy and for achieving a PTC-like sustained HIV remission in the absence of ART.

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Plaksa, I. L., M. R. Savchuk, N. V. Shved, N. A. Savelov, D. N. Khmelkova, А. A. Isaev y R. V. Deev. "Mutation profile of the tall cell variant of papillary thyroid carcinoma: analysis of 5 cases using wide-panel next-generation sequencing". Head and Neck Tumors (HNT) 11, n.º 1 (24 de abril de 2021): 78–85. http://dx.doi.org/10.17650/2222-1468-2021-11-1-78-85.

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The study objective is to analyze the mutation profile of the tall cell variant (TCV) of papillary thyroid carcinoma (PTC).Materials and methods. The main inclusion criteria according to the WHO classification (2017) was PTC composed of at least 30 % of tall cells. Genetic examination was conducted using the FoundationOne CDx assay (USA) with median depth of coverage of >500x. This study included 5 patients (1 man and 4 women) with a mean age of 52.6 years (range: 48-56 years). The tumor size varied between 0.4 x 0.5 cm and 11.0 x 9.0 cm. All patients have undergone surgical treatment: hemithyroidectomy for patient No. 1 with a small tumor (pT1b); thyroidectomy for patient No. 2 (pT3b); extensive thyroidectomy with the removal of paratracheal tissue for patients No. 3, 4, and 5 (No. 3 - pT3bN0; No. 4 - pT3bN1b; No. 5 - pT3bN1b). Three out of the five patients also had adenomatous goiter. The mean follow-up time was 3.4 to 5.2 years.Results. Tumors in all patients were characterized by low mutational load (0 to 4 mutations per 1 million nucleotides (megabase)) and no microsatellite instability. All study participants were found to have p.V600E mutation in the BRAF gene; two patients had c.-124C>T mutation in the promoter region of the TERT gene. All patients carried mutations with unknown clinical significance: p.V562I in the EPHB1 gene (in 2 patients); mutations in the genes AR, CREBBP, EP300, ERCC4, FLT1, IKBKE, JAK2, MAF, MLL2, MST1R, MYC, MYCL1, NTRK2, TSC2 (each mutation registered in one patient). One individual with the largest tumor and the most aggressive disease was found to have amplifications of the BTG2, MAP3K1, SMAD2, and TBX3 genes.Conclusion. In 5 patients analyzed in this study, the mutation profile of TCV PTC was characterized by low mutational load, no microsatellite instability, and presence of p.V600E mutation in the BRAF gene in all cases. Some patients also had c.-124C>T mutation in the TERT gene and p.V562I mutation in the EPHB1 gene.

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Lee, Young Ah, Hae Woon Jung, Hwa Young Kim, Hoonsung Choi, Hyun-Young Kim, J. Hun Hah, Do Joon Park et al. "Pediatric Patients With Multifocal Papillary Thyroid Cancer Have Higher Recurrence Rates Than Adult Patients: A Retrospective Analysis of a Large Pediatric Thyroid Cancer Cohort Over 33 Years". Journal of Clinical Endocrinology & Metabolism 100, n.º 4 (1 de abril de 2015): 1619–29. http://dx.doi.org/10.1210/jc.2014-3647.

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Context:Large-sample studies with long-term follow-up data are limited for pediatric patients with thyroid cancer.Objective:Secular changes in clinicopathological characteristics and outcomes in pediatric patients with thyroid cancer were investigated and compared with those of adults.Design and Patients:A retrospective review of 150 pediatric patients with thyroid cancer managed between 1980 and 2013 was conducted. The long-term outcomes of 124 patients followed up for 12 months or longer were evaluated. Predictors of recurrence-free survival (RFS) in pediatric patients with papillary thyroid cancer (ped-PTC group) were compared with those of 3071 adult patients.Results:The proportion of small tumors (<1 cm) increased from 9.0% before 2010 to 36.8% after 2010 (P < .001); however, neither pathological presentations such as multifocality, extrathyroidal extension (ETE), lymph node (LN) metastasis, or lung metastasis nor the RFS rate changed over time. The 5- and 10-year recurrence rates were 14.5% and 34.4% in pediatric patients, respectively. In respective analyses of the ped-PTC group and patients of all ages with papillary thyroid cancer (all ages group), the rates of ETE, LN metastasis, and lung metastasis were higher with younger age (all P for trend <.05). RFS was lower in the pediatric than the adult patients aged 20–54 years (P < .005) and was comparable with that of older patients (≥55 y). Only tumor multifocality and size predicted recurrence in the ped-PTC group (P < .05), whereas LN metastasis and ETE also predicted recurrence in the all-ages group (P < .01). Among patients in the all-ages group with multifocal tumors, pediatric patients had the lowest RFS (P < .05).Conclusions:The pathological characteristics and recurrence rates of pediatric thyroid cancer have not changed over 33 years. Although younger patients present with more advanced disease, multifocality rather than age at diagnosis predicted recurrence. Recurrence was higher in pediatric than adult patients with multifocal papillary thyroid cancer.

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Song, Young Shin, Byung-Hee Kang, Seungbok Lee, Seong-Keun Yoo, Young Sik Choi, Jungsun Park, Dong Yoon Park, Kyu Eun Lee, Jeong-Sun Seo y Young Joo Park. "Genomic and Transcriptomic Characteristics According to Size of Papillary Thyroid Microcarcinoma". Cancers 12, n.º 5 (25 de mayo de 2020): 1345. http://dx.doi.org/10.3390/cancers12051345.

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It is controversial as to whether papillary thyroid microcarcinoma (PTMC) has some genomic and transcriptomic characteristics that differentiate between an early-stage lesion that would eventually evolve into the larger papillary thyroid cancer (PTC), and an occult indolent cancer in itself. To investigate this, we comprehensively elucidated the genomic and transcriptomic landscapes of PTMCs of different sizes, using a large-scaled database. This study included 3435 PTCs, 1985 of which were PTMCs. We performed targeted next-generation sequencing for 221 PTCs and integrated these data with the data including The Cancer Genome Atlas (TCGA) project. The frequency of v-raf murine sarcoma viral oncogene homolog B (BRAF)V600E mutation was higher in PTMCs >0.5 cm than that in very small PTMCs (≤0.5 cm) and decreased again in PTCs >2 cm. Among PTMCs, the prevalence of mutations in rat sarcoma (RAS) and telomerase reverse transcriptase (TERT) promoter was not significantly different according to their size, but lower than in large PTCs. There was no change in the tumor mutational burden, the number of driver mutations, and transcriptomic profiles with tumor size, among PTMCs and all PTCs. Although a few genes with differential expression and TERT promoter mutations were found in a few PTMCs, our findings showed that there were no useful genomic or transcriptomic characteristics for the prediction of the future progression of PTMC.

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Rahim, Bushra. "Decentralized decision making and educational outcomes in public schools". International Journal of Educational Management 33, n.º 7 (4 de noviembre de 2019): 1625–40. http://dx.doi.org/10.1108/ijem-04-2018-0143.

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Purpose Devolution of fiscal and administrative autonomy to public schools is a global phenomenon now. Various models of school autonomy have been adopted both in developing and developed countries. The purpose of this paper is to explore the impact of devolution of fiscal autonomy to public primary schools through Parent–Teacher Councils (PTCs) on retention of primary school children in the Khyber Pakhtunkhwa (KP) province, Pakistan. Design/methodology/approach Two sources of data were used to analyze the research question: Education Management Information System for the years 2006–2011 and 2007–2012, and a specially designed survey questionnaire used to compile information about PTCs from 222 public primary schools in the KP Province. Multiple linear regressions were conducted to examine whether PTC reforms are related to retention rates. An education production function approach was used to examine the effect of “inputs” (PTC reform) on “outputs” (retention). Findings The regression results indicate that reforms in procedural mechanisms to spend PTC budget and schools with separate classrooms for each grade level are significant in improving retention to the last grade of primary. The results also indicate that retention in all-girls’ schools tend to be significantly lower compared to all-boys’ schools. Research limitations/implications First, the integration of data sets resulted in a small sample size, 361 schools, out of which the researcher could visit only 222 schools (10 schools per district) due to time and financial constraints. There may be a probability that with a larger sample size the author findings may look slightly different. However, this is the only current data set collected by the researcher in KP, Pakistan. Second, an ideal way of calculating retention is to track each and every child enrolled in a school over a period of five years and to calculate retention at the end of Grade 5 called true cohort model. However, due to unavailability of such kind of data, a more commonly used method, called reconstructed cohort method, is employed. In this method, data on enrollment by grade are used for six consecutive years, with an assumption that the student flow rates will remain unchanged over time and across grades. Practical implications The findings of this study provide vital policy input to the Government of Pakistan in particular and other developing countries in general. The study reveals that PTCs have critical impacts on educational outcomes, school productivity and return on public sector educational investment thus providing an impetus for further strengthening of PTC and community participation. Besides, this study offers significant implications as to how school-based management programs will lead to outcomes under resource scarcity in developing countries. Social implications The paper has implications for the role of school leadership and community participation and for how to engender community involvement in marginalized areas where communities often do not have the time, resources or confidence to participate in their schools. Besides, community participation in parent–teacher meetings means that the school budget is spent transparently and with consensus. Hence, the chances of misuse of funds are minimized to a considerable extent, a dilemma faced by many developing countries. Finally, the collection of PTC-related data regularly especially details about budget allocated, spent and, the unutilized budget may result in better record keeping, which was found lacking during the visit. Originality/value The uniqueness and originality of this paper can be gauged from the fact that no systematic study exists with regards to the impact of school autonomy on students’ retention to the last grade of primary in KP province – a poor and conflict-ridden region in a low-income country (Pakistan). Also, the data collection from primary and secondary sources was not an easy task. However, the researcher as a civil servant has to use personal contacts to collect primary and secondary data. Hence, this study is unique and first of its kind in nature. No such research has been conducted so far by any researcher, especially in KP.

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Wang, Zhengshi, Qian Zhang, Hongmei Ye, Chengyou Jia, Zhongwei Lv, Jun Liu y Zhiqiang Yin. "TUMOR SIZE IS AN INDEPENDENT PREDICTOR OF MORTALITY RISK IN DIFFERENTIATED THYROID CANCER PATIENTS WITH T4 DISEASE". Endocrine Practice 26, n.º 5 (mayo de 2020): 499–507. http://dx.doi.org/10.4158/ep-2019-0385.

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Objective: The eighth edition of the American Joint Committee on Cancer (AJCC) guideline on the tumor-node-metastasis staging system has been applied in clinical practice for thyroid cancer since 2018. However, using these criteria, a few studies have shown no significant difference between stage III and IV diseases amongst the differentiated thyroid cancer (DTC) patients. Thus, we aimed to study the underlying reason behind this observation. Methods: Patients were selected from the Surveillance, Epidemiology, and End Results database between 2004 and 2015. The Cox proportional hazards regression model was used for the univariate and multivariate analyses to plot the Kaplan-Meier survival curves for overall survival (OS) and disease-specific survival (DSS). Results: A total of 1,431 patients had a median tumor size of 3.0 cm (range: 0.1 to 50 cm). When stratified by tumor size (≤2 cm, 2 to 4 cm, and >4 cm), lower survival rates were observed in patients with stage III (T4a) cancer and large tumor size than in those with stage IVA (T4b) cancer and small tumor size. Univariate and multivariate analyses showed that tumor size (≤4 cm versus >4 cm) is an independent prognostic factor for OS ( P<.001) and DSS ( P<.001) in DTC patients with T4a and T4b diseases. Conclusion: Tumor size is an independent prognostic factor for OS and DSS in DTC patients with T4 disease; tumor size-related modification of the T4 category can improve the AJCC staging system for DTC patient with stage III–IV diseases. Abbreviations: AJCC = American Joint Committee on Cancer; CI = confidence interval; DSS = disease-specific survival; DTC = differentiated thyroid cancer; FTC = follicular thyroid cancer; HR = hazard ratio; OS = overall survival; PTC = papillary thyroid cancer; SEER = Surveillance, Epidemiology, and End Results; TNM = tumor-node-metastasis

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Haub, Michael, Martin Bogner, Thomas Guenther, André Zimmermann y Hermann Sandmaier. "Development and Proof of Concept of a Miniaturized MEMS Quantum Tunneling Accelerometer Based on PtC Tips by Focused Ion Beam 3D Nano-Patterning". Sensors 21, n.º 11 (30 de mayo de 2021): 3795. http://dx.doi.org/10.3390/s21113795.

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Most accelerometers today are based on the capacitive principle. However, further miniaturization for micro integration of those sensors leads to a poorer signal-to-noise ratio due to a small total area of the capacitor plates. Thus, other transducer principles should be taken into account to develop smaller sensors. This paper presents the development and realization of a miniaturized accelerometer based on the tunneling effect, whereas its highly sensitive effect regarding the tunneling distance is used to detect small deflections in the range of sub-nm. The spring-mass-system is manufactured by a surface micro-machining foundry process. The area of the shown polysilicon (PolySi) sensor structures has a size smaller than 100 µm × 50 µm (L × W). The tunneling electrodes are placed and patterned by a focused ion beam (FIB) and gas injection system (GIS) with MeCpPtMe3 as a precursor. A dual-beam system enables maximum flexibility for post-processing of the spring-mass-system and patterning of sharp tips with radii in the range of a few nm and initial distances between the electrodes of about 30–300 nm. The use of metal–organic precursor material platinum carbon (PtC) limits the tunneling currents to about 150 pA due to the high inherent resistance. The measuring range is set to 20 g. The sensitivity of the sensor signal, which depends exponentially on the electrode distance due to the tunneling effect, ranges from 0.4 pA/g at 0 g in the sensor operational point up to 20.9 pA/g at 20 g. The acceleration-equivalent thermal noise amplitude is calculated to be 2.4–3.4 mg/Hz. Electrostatic actuators are used to lead the electrodes in distances where direct quantum tunneling occurs.

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Garg, N., D. Bakhshinyan, B. Manoranjan, C. Venugopal, R. Hallett, S. Mahendram, T. Vijayakumar et al. "PS1 - 170 Bmi1 is a Therapeutic Target in Recurrent Childhood Medulloblastoma". Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43, S4 (octubre de 2016): S10. http://dx.doi.org/10.1017/cjn.2016.358.

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Medulloblastoma (MB) is the most common malignant pediatric brain tumour, and is categorized into four molecular subgroups, with Group 3 MB having the worst prognosis due to the highest rate of metastatic dissemination and relapse. In this work, we describe the epigenetic regulator Bmi1 as a novel therapeutic target for treatment of recurrent Group 3 MB. Through comparative profiling of primary and recurrent MB, we show that Bmi1 defines a treatment-refractory cell population that is uniquely targetable by a novel class of small molecule inhibitors. We have optimized an in vivo mouse-adapted therapy model that has the advantage of generating recurrent, human, treatment-refractory MBs. Our preliminary studies showed that although chemoradiotherapy administered to mice engrafted with human MB showed reduction in tumour size, Bmi1 expression was enriched in the post-treatment residual tumour. Furthermore, we found that knockdown of Bmi1 in human recurrent MB cells decreases proliferation and self-renewing capacities of MB cells in vitro as well as both tumour size and extent of spinal leptomeningeal metastases in vivo. Oral administration of a potent Bmi1 inhibitor, PTC 028, resulted in a marked reduction in tumour burden and an increased survival in treatment cohort. Bmi1 inhibitors showed high specificity for MB cells and spared normal human neural stem cells, when treated with doses relevant for MB cells. As Group 3 medulloblastoma is often metastatic and uniformly fatal at recurrence, with no current or planned trials of targeted therapy, an efficacious agent such as Bmi1 inhibitor could be rapidly transitioned to clinical trials.

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Kint, Johan F., Janneke E. van den Bergh, Rogier E. van Gelder, Erik A. Rauws, Dirk J. Gouma, Otto M. van Delden y Johan S. Laméris. "Percutaneous Treatment of Common Bile Duct Stones: Results and Complications in 110 Consecutive Patients". Digestive Surgery 32, n.º 1 (2015): 9–15. http://dx.doi.org/10.1159/000370129.

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Background/Aims: Choledocholithiasis is a common complication of cholecystolithiasis, occurring in 15-20% of patients who have gallbladder stones. Endoscopic retrograde cholangio-pancreatography is the standard treatment. When this is not possible or not feasible, percutaneous transhepatic stone removal is an alternative treatment. In this retrospective study, we analyze 110 patients who were treated with percutaneous transhepatic removal of Common Bile Duct (CBD) stones. Patients and Methods: Between March 1998 and September 2013 110 patients (61 men, 49 women; aged 14-96, mean age 69.7 years) with confirmed bile duct stones were included. PTC was done using ultrasound and fluoroscopy. Balloon dilatation of the papilla was done with 8-12 mm balloons. If stone size exceeded 10 mm, mechanical lithotripsy was performed. Stones were then removed by percutaneous extraction or evacuation into the duodenum. Results: In 104 patients (104/110; 94.5%) total stone clearance of the CBD was achieved. A total of 12 complications occurred (10.9%), graded with the Clavien-Dindo scale as IVa, IVb, and V, respectively; hypoxia requiring resuscitation, sepsis and death due to ongoing cholangiosepsis (n = 1, 4, 1). Minor complications I, II, and IIIa included: small liver abscess, pleural empyema, transient hemobilia and mild fever (n = 1, 1, 2, 2). Conclusion: Percutaneous removal of CBD stones is an effective alternative treatment, when endoscopic treatment is contra-indicated, fails or is not feasible. It is effective, has a low complication rate and using deep sedation potentially requires only a very limited number of treatment sessions.

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Thakur, Shilpa, Darryl Nousome, Kshama Aswath, Stephanie Cardenas, Sonam Kumari, Ruth Adewale, Maria Merino et al. "Abstract 769: Genomic and transcriptomic characterization of benign and malignant struma ovarii". Cancer Research 82, n.º 12_Supplement (15 de junio de 2022): 769. http://dx.doi.org/10.1158/1538-7445.am2022-769.

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Abstract Background: Struma Ovarii (SO) is a rare ovarian teratoma characterized by the presence of thyroid tissue in >50% of the tumor. The majority of SO are benign; however, malignant transformation occurs in up to 5% of the cases. The molecular foundations of benign and malignant SO are grossly unknown. Therefore, the goal of this study was to perform the first comprehensive genomic and transcriptomic analysis of the benign and malignant SO. Material and Method: We performed whole-exome sequencing (WES) and targeted RNA-sequencing (seq) on the DNA and RNA extracted from formalin-fixed paraffin-embedded SO tumor tissue samples. WES library was prepared using Agilent’s SureSelect XT HS2 kit, with 4 samples failing the quality assessment (QA). Variants were called from GATK processed WES data and annotated using VEP (with ClinVar and COSMIC databases). The targeted RNA-Seq library was prepared using the TruSight RNA Pan-Cancer Panel kit covering 1385 cancer genes, with all samples passing QA. The clinical characteristics of the study cohort were summarized by percentages for categorical variables and medians with 25-75% interquartile ranges for continuous variables. Results: The study included 31 tissue samples - 21 benign and 10 malignant, including 6 cases of papillary thyroid cancer (PTC), 3 of follicular variant of PTC, and 1 of follicular thyroid cancer. Patients with benign SO were characterized by the median age at diagnosis of 39 years [33-54], tumor size of 3.1 cm [2.5-5.8], while the patients with malignant SO presented at age of 45 [28-54], tumor size of 6 cm [0.85-14] and metastatic disease in 30% (3/10) - 2 patients with peritoneal metastases and 1 patient with pelvic lymph node metastases. The E1A Binding Protein P300, EP300 (6/27), and Isocitrate dehydrogenase, IDH2 (5/27) were the topmost mutated genes in the SO samples. Malignant SO samples were characterized with the presence of pathogenic variants of KRAS (pQ61L and pG12V), NRAS (pQ61R), TP53 (splice site) mutations, and Nuclear Receptor Binding SET Domain Protein 1 (NSD1) fusion as the most common molecular drivers. Among benign SO samples, the most common driver was Thyroglobulin (TG) fusion with either Guanine Nucleotide binding protein (GNAS) or Rac Family Small GTPase 1 (RAC1). Differential expression analysis showed that the member of tumor suppressor family - tumor protein 63 (TP63) was the most downregulated (Log2FC = -3), while Double-sex and Mab-3 Related Transcription Factor 1 (DMRT1), implicated in the development of germ cell tumors, was the most upregulated gene in malignant SO samples over benign (Log2FC = 2.1; padj<0.05). Conclusions: In contrast to cancer arising from the thyroid gland, characterized by BRAFV600E as the most common mutation, malignant SO belongs to RAS-like tumors. The downregulation of tumor suppressors and upregulation of DMRT1 might be implicated in the malignant transformation of SO. Citation Format: Shilpa Thakur, Darryl Nousome, Kshama Aswath, Stephanie Cardenas, Sonam Kumari, Ruth Adewale, Maria Merino, Esra Dikoglu, Padmasree Veeraraghavan, Sriram Gubbi, Joanna Klubo-Gwiezdzinska. Genomic and transcriptomic characterization of benign and malignant struma ovarii [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 769.

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Mat Nor, Mohd Basri y Azrina Md Ralib. "Procalcitonin Clearance for Early Prediction of Survival in Critically Ill Patients with Severe Sepsis". Critical Care Research and Practice 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/819034.

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Introduction. Serum procalcitonin (PCT) diagnosed sepsis in critically ill patients; however, its prediction for survival is not well established. We evaluated the prognostic value of dynamic changes of PCT in sepsis patients.Methods. A prospective observational study was conducted in adult ICU. Patients with systemic inflammatory response syndrome (SIRS) were recruited. Daily PCT were measured for 3 days. 48 h PCT clearance (PCTc-48) was defined as percentage of baseline PCT minus 48 h PCT over baseline PCT.Results. 95 SIRS patients were enrolled (67 sepsis and 28 noninfectious SIRS). 40% patients in the sepsis group died in hospital. Day 1-PCT was associated with diagnosis of sepsis (AUC 0.65 (95% CI, 0.55 to 0.76)) but was not predictive of mortality. In sepsis patients, PCTc-48 was associated with prediction of survival (AUC 0.69 (95% CI, 0.53 to 0.84)). Patients with PCTc-48 > 30% were independently associated with survival (HR 2.90 (95% CI 1.22 to 6.90)).Conclusions. PCTc-48 is associated with prediction of survival in critically ill patients with sepsis. This could assist clinicians in risk stratification; however, the small sample size, and a single-centre study, may limit the generalisability of the finding. This would benefit from replication in future multicentre study.

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Dameria, Flora, Marini Stephanie, Ria Kodariah, Diah Rini Handjari, Ening Krisnuhoni y Nur Rahadiani. "Clinical, Molecular, and Histopathological Aspect of Primary Biliary Cholangitis". Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy 20, n.º 3 (23 de julio de 2020): 177–83. http://dx.doi.org/10.24871/2032019177-183.

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Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune liver disease which tends to be chronic and progressive in nature that is marked by the presence of cholangitis and small size biliary duct destruction which may cause cirrhosis or even liver failure. PBC incidence increases because PBC can now be diagnosed earlier and is due to the increasing survival rate of PBC patients. Diagnosis of PBC can be confirmed in asymptomatic state if in the indirect immunofluorescence (IIF) examination revealed AMA positive, and there is an abnormal liver function. Etiopathogenesis of PBC is multifactorial which involves genetic and environmental factors. Genetic factors which contribute to the incidence of PBC are HLA and non-HLA genes, while in the environmental factors, the triggering factors of PBC are bacterial infection and xenobiotic. Interaction of these factors causes the development of E2 subunit pyruvate dehydrogenase complex (PDC-E2) and antimitochondrial antibody (AMA) as the causing autoantigen of biliary duct desctruction in PBC, mediated by the immune system. PBC stage is divided into minimal, mild, moderate and severe. Ursodeoxycholic acid (UDCA) is the first line therapy for PBC, while obeticholic acid (OCA) and fibrate is used as the second line. Liver transplantation is the definitive therapy for PBC where disease progresses into the advanced stage, although the patients have received medical treatment.

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Huyck, Bart, Hans Joachim Ferreau, Moritz Diehl, Jos De Brabanter, Jan F. M. Van Impe, Bart De Moor y Filip Logist. "Towards Online Model Predictive Control on a Programmable Logic Controller: Practical Considerations". Mathematical Problems in Engineering 2012 (2012): 1–20. http://dx.doi.org/10.1155/2012/912603.

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Given the growing computational power of embedded controllers, the use of model predictive control (MPC) strategies on this type of devices becomes more and more attractive. This paper investigates the use of online MPC, in which at each step, an optimization problem is solved, on both a programmable automation controller (PAC) and a programmable logic controller (PLC). Three different optimization routines to solve the quadratic program were investigated with respect to their applicability on these devices. To this end, an air heating setup was built and selected as a small-scale multi-input single-output system. It turns out that the code generator (CVXGEN) is not suited for the PLC as the required programming language is not available and the programming concept with preallocated memory consumes too much memory. The Hildreth and qpOASES algorithms successfully controlled the setup running on the PLC hardware. Both algorithms perform similarly, although it takes more time to calculate a solution for qpOASES. However, if the problem size increases, it is expected that the high number of required iterations when the constraints are hit will cause the Hildreth algorithm to exceed the necessary time to present a solution. For this small heating problem under test, the Hildreth algorithm is selected as most useful on a PLC.

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Sherafat-Kazemzadeh, Rosa, Sanjeev N. Mehta, Marguerite M. Care, Mi-Ok Kim, David A. Williams y Susan R. Rose. "Small pituitary size in children with Fanconi Anemia". Pediatric Blood & Cancer 49, n.º 2 (2007): 166–70. http://dx.doi.org/10.1002/pbc.21148.

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Trull, Thomas W., Abraham Passmore, Diana M. Davies, Tim Smit, Kate Berry y Bronte Tilbrook. "Distribution of planktonic biogenic carbonate organisms in the Southern Ocean south of Australia: a baseline for ocean acidification impact assessment". Biogeosciences 15, n.º 1 (3 de enero de 2018): 31–49. http://dx.doi.org/10.5194/bg-15-31-2018.

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Abstract. The Southern Ocean provides a vital service by absorbing about one-sixth of humankind's annual emissions of CO2. This comes with a cost – an increase in ocean acidity that is expected to have negative impacts on ocean ecosystems. The reduced ability of phytoplankton and zooplankton to precipitate carbonate shells is a clearly identified risk. The impact depends on the significance of these organisms in Southern Ocean ecosystems, but there is very little information on their abundance or distribution. To quantify their presence, we used coulometric measurement of particulate inorganic carbonate (PIC) on particles filtered from surface seawater into two size fractions: 50–1000 µm to capture foraminifera (the most important biogenic carbonate-forming zooplankton) and 1–50 µm to capture coccolithophores (the most important biogenic carbonate-forming phytoplankton). Ancillary measurements of biogenic silica (BSi) and particulate organic carbon (POC) provided context, as estimates of the biomass of diatoms (the highest biomass phytoplankton in polar waters) and total microbial biomass, respectively. Results for nine transects from Australia to Antarctica in 2008–2015 showed low levels of PIC compared to Northern Hemisphere polar waters. Coccolithophores slightly exceeded the biomass of diatoms in subantarctic waters, but their abundance decreased more than 30-fold poleward, while diatom abundances increased, so that on a molar basis PIC was only 1 % of BSi in Antarctic waters. This limited importance of coccolithophores in the Southern Ocean is further emphasized in terms of their associated POC, representing less than 1 % of total POC in Antarctic waters and less than 10 % in subantarctic waters. NASA satellite ocean-colour-based PIC estimates were in reasonable agreement with the shipboard results in subantarctic waters but greatly overestimated PIC in Antarctic waters. Contrastingly, the NASA Ocean Biogeochemical Model (NOBM) shows coccolithophores as overly restricted to subtropical and northern subantarctic waters. The cause of the strong southward decrease in PIC abundance in the Southern Ocean is not yet clear. The poleward decrease in pH is small, and while calcite saturation decreases strongly southward, it remains well above saturation ( > 2). Nitrate and phosphate variations would predict a poleward increase. Temperature and competition with diatoms for limiting iron appear likely to be important. While the future trajectory of coccolithophore distributions remains uncertain, their current low abundances suggest small impacts on overall Southern Ocean pelagic ecology.

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Butink, M., C. Webers, S. Verstappen, R. Christensen, L. Falzon, H. Bijlsma, G. R. Burmester y A. Boonen. "OP0033 EFFECTIVENESS OF NON-PHARMACOLOGICAL INTERVENTIONS TO PROMOTE WORK PARTICIPATION IN PEOPLE WITH RMDs: A SYSTEMATIC REVIEW AND META-ANALYSIS". Annals of the Rheumatic Diseases 81, Suppl 1 (23 de mayo de 2022): 24.2–24. http://dx.doi.org/10.1136/annrheumdis-2022-eular.978.

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BackgroundWork participation among people with rheumatic and musculoskeletal diseases (RMDs) remains reduced when compared to the general population. A EULAR taskforce was established to agree on Points to Consider (PtC) to support people with RMD in healthy and sustainable work participation. Non-pharmacological interventions (NPI) could have an important role in improving work participation in RMDs. However, a comprehensive evidence synthesis of the effectiveness of NPIs in people with RMDs is lacking.ObjectivesTo summarise the literature on effectiveness of NPIs on work participation in people with RMDs.MethodsA search in four databases (MEDLINE, EMBASE, CENTRAL and CINAHL) was performed. Randomised Controlled Trials (RCTs) and Longitudinal Observational Studies (LOS) assessing non-pharmacological/non-surgical interventions until August 2020 were screened. Studies including people with any RMD (except low back pain or work-related RMDs) and assessing a work participation outcome domain (sick leave, work status, presenteeism) were considered eligible. For qualitative evidence synthesis, RCTs and LOS were considered. For quantitative evidence synthesis, only RCTs were considered. For each randomized comparison, standardised mean differences (SMDs) were calculated for the three outcome domains and used as effect size in the meta-analyses; i.e. a negative SMD favouring the NPI over control. Next, Mixed Effects Meta-Regression Analyses were performed, with random effects for randomised comparisons, and a fixed effect factor for the stratified subgroups of clinical interest. Subgroups within diseases (musculoskeletal pain disorders vs. other types of RMDs), risk status for sick leave at baseline (on sick leave or at risk for sick leave; not at risk for sick leave; a combination; or not specified) and single vs. multiple component NPIs were pre-defined. Risk of Bias (RoB) of RCTs was assessed using the Cochrain tool.ResultsOut of 8,864 records, 64 studies (71 treatment comparisons) were included. Studies usually included a mixed population of several RMDs (42%). Most NPIs were conducted in a clinical setting (n=44, 62%) and NPIs usually had multiple components (n=57, 80%), such as vocational support combined with physical training (n=18, 25%). Sick leave was the most frequently reported outcome domain (n=56, 88%). In the qualitative syntheses, 30%/50%/29% of interventions were considered plausible in improving sick leave, work status and presenteeism, respectively.In the quantitative synthesis, NPIs (37 RCTs, 42 comparisons with mostly moderate to high RoB) showed small to moderate effect sizes, favouring NPIs over comparators for sick leave (SMD=-0.23, 95%CI -0.33 to -0.13), work status (SMD=-0.38, 95%CI -0.63 to -0.12) and presenteeism (SMD=-0.25, 95%CI -0.39 to -0.12). The forest plot for sick leave is shown (Figure 1).Subgroup analyses for sick leave revealed that, compared to control, NPIs were not effective in musculoskeletal pain disorders, in contrast to the other types of RMDs. For both other subgroup analyses (baseline risk for sick leave; single vs. multicomponent NPI), NPIs improved sick leave similarly in subgroups compared to the control. Subgroup analyses for work status and presenteeism had generally similar effects in subgroups, but the interpretation requires caution in view of the small number of comparisons. Of note, clinical and methodological heterogeneity between studies was substantial, with some concerns about methodological quality related blinding and completeness of follow up.ConclusionOverall, NPIs seem to have significant, but on the average population level only small to moderate effects on sick leave, work status and presenteeism in RMDs. However, effects on sick leave varied substantially between subgroups. This synthesis suggests that tailoring NPIs to individuals’ needs and context could be clinically valuable.Disclosure of InterestsNone declared.

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Couto, Maíra Lara y Maristela Da Silva Souza. "A RELAÇÃO ENTRE A FUNDAMENTAÇÃO DO TRABALHO PEDAGÓGICO DOS PROFESSORES DO CEFD-UFSM E OS PROJETOS PEDAGÓGICOS DE CURSO". Germinal: Marxismo e Educação em Debate 6, n.º 1 (27 de agosto de 2014): 184. http://dx.doi.org/10.9771/gmed.v6i1.10125.

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Este estudo investigou a relação entre a fundamentação do trabalho pedagógico dos professores do CEFD-UFSM e os Projetos Pedagógicos de Cursos de EF (PPC). Fundamentadas no método do Materialismo Histórico Dialético, foram realizadas entrevistas com professores sobre os PPC dos cursos. Concluímos que os professores do CEFD-UFSM não se baseiam nos PPC para fundamentarem sua prática pedagógica. Isto se torna preocupante já que em breve a Licenciatura Ampliada em EF estará em prática. Apesar disso, entendemos que o novo curso, sendo pauta transitória, na medida em que é expressão de reivindicações da base contribuirá com novos patamares de conhecimento.

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Li, Tian, Hongjian Yu, Jing Tian, Junxia Liu, Tonghao Yuan, Shaoze Xiao, Huaqiang Chu y Bingzhi Dong. "PAC-UF Process Improving Surface Water Treatment: PAC Effects and Membrane Fouling Mechanism". Membranes 12, n.º 5 (29 de abril de 2022): 487. http://dx.doi.org/10.3390/membranes12050487.

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In this study, the water purification effect and membrane fouling mechanism of two powdered activated carbons (L carbon and S carbon) enhancing Polyvinylidene Fluoride (PVDF) ultrafiltration (UF) membranes for surface water treatment were investigated. The results indicated that PAC could effectively enhance membrane filtration performance. With PAC addition, organic removal was greatly enhanced compared with direct UF filtration, especially for small molecules, i.e., the S-UF had an additional 25% removal ratio of micro-molecule organics than the direct UF. The S carbon with the larger particle size and lower specific surface area exhibited superior performance to control membrane fouling, with an operation duration of S-UF double than the direct UF. Therefore, the particle size and pore structure of carbon are the two key parameters that are essential during the PAC-UF process. After filtration, acid and alkaline cleaning of UF was conducted, and it was found that irreversible fouling contributed the most to total filtration resistance, while the unrecoverable irreversible resistance ratio with acid cleaning was greater than that with alkaline cleaning. With PAC, irreversible UF fouling could be relieved, and thus, the running time could be extended. In addition, the membrane foulant elution was analyzed, and it was found to be mainly composed of small and medium molecular organic substances, with 12% to 21% more polysaccharides than proteins. Finally, the hydrophilicity of the elution was examined, and it was observed that alkaline cleaning mainly eluted large, medium, and small molecules of hydrophilic and hydrophobic organic matter, while acid cleaning mainly eluted small molecules of hydrophilic organic matter.

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Shibata, Ken, Michio Endo, Naomichi Yamamoto, Jun Yoshinaga, Yukio Yanagisawa, Osamu Endo, Sumio Goto, Minoru Yoneda, Yasuyuki Shibata y Masatoshi Morita. "Temporal Variation of Radiocarbon Concentration in Airborne Particulate Matter in Tokyo". Radiocarbon 46, n.º 1 (2004): 485–90. http://dx.doi.org/10.1017/s0033822200039795.

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The temporal radiocarbon variation (in terms of percent Modern Carbon: pMC) of size-fractionated airborne particulate matter (APM) collected in Tokyo between April 2002 and February 2003 was analyzed in order to get an insight into the sources of carbonaceous particles. Results indicated significant biogenic origins (approximately 40 pMC on average). In general, the seasonal and particle size variations in pMC were relatively small, with 2 exceptions: elevated pMC in coarse particles in April and October 2002, and relatively low pMC in the finest particle size fraction collected in August 2002. The former finding could be tentatively attributed to the abundance of coarse particles of biological origins, such as pollen; the latter might be due to an increased fraction of anthropogenic secondary particles.

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Tao, Yukari, Hiroshi Maegawa, Satoshi Ugi, Kazuhiro Ikeda, Yoshio Nagai, Katsuya Egawa, Takaaki Nakamura et al. "The Transcription Factor AP-2β Causes Cell Enlargement and Insulin Resistance in 3T3-L1 Adipocytes". Endocrinology 147, n.º 4 (1 de abril de 2006): 1685–96. http://dx.doi.org/10.1210/en.2005-1304.

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We have reported the association of variations in the activating protein-2β (AP-2β) transcription factor gene with type 2 diabetes. This gene was preferentially expressed in 3T3-L1 adipocytes in a differentiation stage-dependent manner, and preliminary experiments showed that subjects with the disease-susceptible allele showed stronger expression in adipose tissue than those without the susceptible allele. Thus, we overexpressed the AP-2β gene in 3T3-L1 adipocytes to clarify whether AP-2β might play a crucial role in the pathogenesis of type 2 diabetes through dysregulation of adipocyte function. In cells overexpressing AP-2β, cells increased in size by accumulation of triglycerides accompanied by enhanced glucose uptake. On the contrary, suppression of AP-2β expression by small interfering RNA inhibited glucose uptake. Enhancement of glucose uptake by AP-2β overexpression was attenuated by inhibitors of phospholipase C (PLC) and atypical protein kinase Cζ/λ (PKCζ/λ), but not by a phosphatidylinositol 3-kinase (PI3-K) inhibitor. Consistently, we found activation of PLC and atypical PKC, but not PI3-K, by AP-2β expression. Furthermore, overexpression of PLCγ enhanced glucose uptake, and this activation was inhibited by an atypical PKC inhibitor, suggesting that the enhanced glucose uptake may be mediated through PLC and atypical PKCζ/λ, but not PI3-K. Moreover, we observed the increased tyrosine phosphorylation of Grb2-associated binder-1 (Gab1) and its association with PLCγ, indicating that Gab1 may be involved in AP-2β-induced PLCγ activation. Finally, AP-2β overexpression was found to relate to the impaired insulin signaling. We propose that AP-2β is a candidate gene for producing adipocyte hypertrophy and may relate to the abnormal characteristics of adipocytes observed in obesity.

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Lan, Shi Hong y Jian Zhang. "The Application of Programmable Controller to Chip Design". Applied Mechanics and Materials 273 (enero de 2013): 722–25. http://dx.doi.org/10.4028/www.scientific.net/amm.273.722.

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In the field of modern industrial control, PLC has become the important equipment in automatic control. With the development of semiconductor technology, chip technology, the embedded PLC chipset emerged. The chipset microcontroller cores, PLC system software is loaded with high-performance, low power consumption, small size and other characteristics. User to flexibly customize according to their needs, using chipsets embedded PLC. This paper described the PLC chip design and application.

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Li, Jing, Yuanwu Liu, Chen Liu, Wentian Huang, Ying Zhang, Minjie Wang, Zhipeng Hou et al. "Enhanced charge transport in ReSe2-based 2D/3D electrodes for efficient hydrogen evolution reaction". Chemical Communications 56, n.º 2 (2020): 305–8. http://dx.doi.org/10.1039/c9cc08076g.

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Ultra-high-density ReSe₂ nanoflakes with uniform small 2D size were grown on porous carbon cloth by CVD. The 2D/3D construction gave more active catalytic sites, and the small size effect and the interfacial C–Se bonding facilitated electron transport between ReSe₂ and PCC.

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Livraghi, Tito, Carlo Ravetto, Luigi Solbiati y Fredy Suter. "Percutaneous Interstitial Chemotherapy of a Small Hepatocellular Carcinoma under Ultrasound Guidance". Tumori Journal 72, n.º 5 (octubre de 1986): 525–27. http://dx.doi.org/10.1177/030089168607200514.

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A small < 3 cm) inoperable hepatocellular carcinoma was treated with percutaneous interstitial chemotherapy (PIC). 5-Fluorouracil was injected by a fine needle under ultrasound guidance. After 3 months a fine needle biopsy (FNB) yielded fibronecrotic material. After 18 months another FNB yielded steatosis and dysplastic cells and the lesion showed no increase in size. PIC could be an interesting alternative treatment for small tumors unresponsive to conventional therapies.

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Nafiu, Akeem Tunde, Danlami Joseph Aduku y Napoleon Ukwubile Abah. "INNOVATIVENESS AND COMPETITIVE ADVANTAGE OF SMALL AND MEDIUM-SIZE ENTERPRISES IN KOGI STATE, NIGERIA". Problems of Management in the 21st Century 17, n.º 1 (20 de diciembre de 2022): 63–77. http://dx.doi.org/10.33225/pmc/22.17.63.

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This study focused on link innovativeness and Competitive Advantage (CA) of Small and Medium-size Enterprise (SMEs). The study examined the effect of Value Capture Innovation (VCI) on the CA, as well as the effect of VPI on the CA of SMEs in Kogi State. The survey research design was adopted. 255 SMEs were surveyed, but 219 owners/managers eventually became active participants. Multi-stage random sampling technique was adopted. The reliability results showed VCI (α=0.917); and VPI (α=0.776). Multiple Regression analysis was used for testing hypotheses. Descriptive statistics aggregated and characterized the data in a straightforward and clear manner. Finding showed that VCI has significant effect on the CA of SMEs in Kogi State, and that (Value Proposition Innovation (VPI) has significant effect on CA of SMEs. The study concluded that SMEs need to possess innovation capabilities so as to enhance reasonable position in the competitive business environment. The study recommended that SME owners should increase their commitment to VCI so as to achieve sustainable CA for their enterprises, and that SME owners should invest in VPI to create effective medium route towards the achievement of sustainable CA of their enterprises. Key words: innovative activity, competitive advantage, value capture innovation, value proposition innovation, new customer relationships

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Zhao, P., S. Takizawa, H. Katayama y S. Ohgaki. "Factors causing PAC cake fouling in PAC–MF (powdered activated carbon-microfiltration) water treatment systems". Water Science and Technology 51, n.º 6-7 (1 de marzo de 2005): 231–40. http://dx.doi.org/10.2166/wst.2005.0642.

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Two pilot-scale powdered activated carbon–microfiltration (PAC–MF) reactors were operated using river water pretreated by a biofilter. A high permeate flux (4 m/d) was maintained in two reactors with different particle sizes of PAC. High concentration (20 g/L) in the PAC adsorption zone demonstrated 60–80% of organic removal rates. Analysis on the PAC cake fouling demonstrated that attached metal ions play more important role than organic matter attached on PAC to the increase of PAC cake resistance. Effects of factors which may cause PAC cake fouling in PAC-MF process were investigated and evaluated by batch experiments, further revealing that small particulates and metal ions in raw water impose prominent influence on the PAC cake layer formation. Fe (II) precipitates after being oxidized to Fe (III) during PAC adsorption and thus Fe(III) colloids display more significant effect than other metal ions. At a high flux, PAC cake layer demonstrated a higher resistance with larger PAC due to association among colloids, metals and PAC particles, and easy migration of small particles in raw water into the void space in the PAC cake layer. Larger PAC possesses much more non-uniform particle size distribution and larger void space, making it easier for small colloids to migrate into the voids and for metal ions to associate with PAC particles by bridge effect, hence speeding up and intensifying the of PAC cake fouling on membrane surface.

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Wang, Lian Sheng y Qing Ming Deng. "A Portable Subway Logistics System for the Transportation of Small and Medium-Size Cargo". Advanced Materials Research 734-737 (agosto de 2013): 1604–8. http://dx.doi.org/10.4028/www.scientific.net/amr.734-737.1604.

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To satisfy the requirement of short delivery time, this paper proposes subway (light rail transport) as vehicle for city delivery and express. With the convenient service, it will improve the efficiency of city logistics and promote the development of e-commerce. The system can effectively avoid the congestion of trucks on road, reduce fuel consumption and reduce the damage to the environment for the subway is driven by electricity. The automated warehouse management system is proposed in this paper, which is built on Siemenss SIMATIC S7 PLC control system and SQL database, and is designed for small and medium-size cargo to make transportation efficient and timely.

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Rathi, Sapna, Sandip Swarnakar y Santosh Kumar. "Design of One-Bit Magnitude Comparator using Photonic Crystals". Journal of Optical Communications 40, n.º 4 (25 de octubre de 2019): 363–67. http://dx.doi.org/10.1515/joc-2017-0084.

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Abstract At present, photonic crystals (PhCs) are used to design various combinational and sequential circuits. In this paper, an all-optical one-bit magnitude comparator is proposed using PhC waveguide without using nonlinear material. It is based on beam interference principle, using T-shaped lattice with silicon dielectric rods in air background. It is demonstrated through finite-difference time-domain simulation and verified numerically using MATLAB simulation. The size of PhC lattice structure can be as small as 19.167a×19.167a, where ‘a’ is the lattice constant of the PhC.

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Liu, Ying-Ying, Gong Ju y Margaret T. T. Wong-Riley. "Distribution and colocalization of neurotransmitters and receptors in the pre-Bötzinger complex of rats". Journal of Applied Physiology 91, n.º 3 (1 de septiembre de 2001): 1387–95. http://dx.doi.org/10.1152/jappl.2001.91.3.1387.

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The pre-Bötzinger complex (PBC), thought to be the center of respiratory rhythm generation, is a cell column ventrolateral to the nucleus ambiguus. The present study analyzed its cellular and neurochemical composition in adult rats. PBC neurons were mainly oval, fusiform, or multipolar in shape and small to medium in size. Neurokinin-1 receptor, a marker of the PBC, was present in the plasma membrane of mostly medium and small neurons and their associated processes and boutons. Among neurons immunoreactive for different neurotransmitter or receptor candidates, various numbers were colocalized with neurokinin-1 receptor. The highest ratio was with nitric oxide synthase (52.72%), and the lowest was with glycine receptors (31.93%). Glutamic acid decarboxylase- and glycine transporter 2-immunoreactive boutons, as well as GABAA receptor-immunoreactive plasma membrane processes and boutons, were also identified in the PBC. PBC neurons exhibited different levels of cytochrome oxidase activity, indicating their various energy demands. Our results suggest that synaptic interactions within the PBC of adult rats involve a variety of neurotransmitter and receptor types and that nitric oxide may play an important role in addition to glutamate, GABA, glycine, and neurokinin.

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Maru, Koichi y Yusaku Fujii. "Proposal of Compact Optical System Using Planar Lightwave Circuit for Precision Measurement Based on Levitation Mass Method". Applied Mechanics and Materials 36 (octubre de 2010): 329–36. http://dx.doi.org/10.4028/www.scientific.net/amm.36.329.

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A method for reducing the size and cost of optical system for precision measurement based on the Levitation Mass Method (LMM) is proposed. In the LMM, a mass levitated using a pneumatic linear bearing with sufficiently small friction is made to collide with the object being tested. The velocity and acceleration of the mass are measured using a compact optical interferometer. The size of the optical system can be drastically reduced by using a planar lightwave circuit (PLC), in which several optical elements are arranged on a planar surface of a silica or semiconductor substrate. Several applications of the PLC to precision measurement will be discussed.

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