Tesis sobre el tema "SK"
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Lopes, Raquel Vieira 1983. "Sk-splines de funções periódicas". [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/306562.
Texto completoDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática Estatística e Computação Científica
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Resumo: Os sk-splines são uma generalização natural dos splines polinomiais, os quais foram introduzidos e tiveram sua teoria básica desenvolvida por Alexander Kushpel nos anos de 1983-1985. Estas funções são importantes em várias aplicações e seu espaço é gerado por translações discretas de uma única função núcleo. Neste trabalho, estudamos condições necessárias e suficientes para a existência e unicidade de sk-splines interpolantes de funções periódicas. Além disso, estudamos a aproximação de funções de determinadas classes por sk-splines nos espaços Lp. Como aplicação estudamos a aproximação de funções infinitamente diferenciáveis e finitamente diferenciáveis por sk- splines
Abstract: The sk-splines are a natural generalization of polynomial splines. They were introduced and their basic theory developed by Alexander Kushpel between 1983 and 1985. These functions are important in many applications and the space of sk-splines is the linear span of shifts of a single kernel K. In this work, we study necessary and sufficient conditions for the existence and uniqueness of sk-splines interpolants of periodic functions. Furthermore, we study the approximation in several classes of functions by sk-splines in the Lp spaces. As an application we study the approximation of infinitely and finitely differentiable functions by sk-splines
Mestrado
Matematica Aplicada
Mestra em Matemática Aplicada
Pucci, Michael. "Restrukturalizace společnosti VÁHOSTAV - SK, a.s". Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359150.
Texto completoBystedt, Rasmus. "Möjlig efterträdare till skolflygplan SK 60". Thesis, Försvarshögskolan, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-4757.
Texto completoKrátka, Barbora. "TRANSFORMACE PRŮMYSLOVÉHO AREÁLU V PARTIZÁNSKÉM (SK)". Master's thesis, Vysoké učení technické v Brně. Fakulta architektury, 2017. http://www.nusl.cz/ntk/nusl-316338.
Texto completoBodlund, Per y Roderik Elfström. "Intersport & Skiljebo SK : Ett vinnande samarbete?" Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-732.
Texto completoSammanfattning
Seminariedatum: 2008-06-04
Nivå: Kandidatuppsats i företagsekonomi, 15 Högskolepoäng
Handledare: Claes Jonsson
Författare: Per Bodlund 1983 Roderik Elfström 1981
pbd04002@student.mdh.se rem03001@student.mdh.se Västerås Västerås
Nyckelord: Relationsmarknadsföring, engagemang, förtroende, kommunikation, relationer, lojalitet.
Titel: Intersport & Skiljebo SK. Ett vinnande samarbete?
Problem: Sponsring är en viktig marknadsföringskanal för näringslivet och en viktig inkomstkälla för det svenska föreningslivet. Det är därför viktigt att relationen mellan sponsor och sponsortagare fungerar och att sponsorerna får ut vad de förväntar sig av samarbetet. Intersport och Skiljebo SK (SSK) har sedan många år tillbaka ett sponsrings- och samarbetsavtal. Intersport sponsrar SSK med utrustning och pengar mot att de får agera som återförsäljare/leverantör till föreningen samt att de hoppas få föreningens medlemmar som lojala kunder. De vet i dagsläget inte det exakta resultatet av samarbetet och är intresserade av att ta reda på om föreningens medlemmar är lojala kunder hos dem. De vill också stärka relationen till föreningen och deras medlemmar. För att kunna ta reda på hur de kan stärka relationen till SSK och medlemmarna i föreningen måste undersökningen visa hur det ser ut idag.
Syfte: Syftet med undersökningen är att beskriva och analysera relationerna mellan Intersport, SSK och SSK:s medlemmar utifrån attributen kommunikation, förtroende och engagemang. Dessa tre attribut är mycket viktiga beståndsdelar i en relation. Vidare är syftet att ta reda på om samarbetet leder till en ömsesidig lojalitet mellan Intersport och SSK respektive en köplojalitet mellan Intersport och SSK:s medlemmar.
Metod: För att kunna beskriva och analysera relationerna och för att ta reda på om det finns en lojalitet används ett något annorlunda angreppssätt där vi frågade alla tre inblandade parter. Det är alltså en triad av relationer där varje relation undersöks utifrån ovan givna attribut. För att få fram svar på hur det förhåller sig i relationerna används intervjuer för Intersport och SSK. För att få fram SSK:s medlemmars åsikter görs en enkätundersökning.
Resultat: Undersökningen visar att det finns brister i relationerna och att köplojaliteten mellan SSK:s medlemmar och Intersport är lägre än förväntat. Den ömsesidiga lojaliteten mellan Intersport och SSK som förening är dock mycket hög.
Abstract
Date: 2008-06-04
Level: Bachelor thesis in business economics, 15 Swedish credits
Supervisor: Claes Jonsson
Authors: Per Bodlund Roderik Elfström
1983 Västerås 1981 Västerås
pbd04002@student.mdh.se rem03001@student.mdh.se
Keywords: Relationship marketing, commitment, trust, communication, connected relationship, loyalty.
Title: Intersport and Skiljebo SK. A winning collaboration?
Problem: Sponsorship is an important marketing channel for the business world and an important income source for the Swedish sports associations. It is therefore important that the relationship between the sponsor and the sponsorship receiver is working and that the sponsors get what they expects of the collaboration. Intersport and Skiljebo SK (SSK) has since many years back a sponsor and collaboration deal. Intersport is giving SSK club equipment and money so they in return can be the retailer and supplier to the club and their members. Intersport hope this collaboration will lead to loyal SSK customers. Intersport does not know the exact result of the collaboration so they are interested to found out if the club members are loyal customers or not. Intersport wants to strengthen the relationship with the club and their members. To be able to do this they have to found out, with the help of this research, how the situation looks today.
Purpose: The purpose with the research is to describe and analyze the relationships between Intersport, SSK club and their members on the basis of the three attributes communication, trust and commitment. These three attributes are all very important parts in a relationship. The purpose is also to found out if the collaboration is leading to a mutual loyalty between Intersport and SSK club and respectively a buying loyalty between Intersport and SSK club members.
Method: To be able to describe and analyze the relationships and to see if there is a loyalty, a rather unusual approach is used were, we ask all three involved parties. It is a triad of relationships where every relation is investigated on the basis of the before mentioned attributes. Interviews were done with Intersport and SSK club to get an answer how the relationship is working. A survey was done to see what opinion SSK club members had about the relationships.
Result: The research show that there are some flaws in the relationships and the buying loyalty between SSK members and Intersport is not as high as Intersport maybe expected. The mutual loyalty between Intersport and SSK club is however very high.
Dukkipati, Saihari Shekar. "SK Channel Clustering in SOD1-G93A Motoneurons". Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1464713486.
Texto completoBrejcha, Lukáš. "Ocenění sportovního klubu SK Slavia Praha a.s". Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-197601.
Texto completoHrubý, Petr. "Analýza práce s fanoušky SK DYNAMO České Budějovice". Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-192415.
Texto completoUksila, Tommi y Thomas Norman. "Bolagiseringens påverkan på elitfotbollen : Fallet Örebro SK Elitfotboll AB". Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27643.
Texto completoGiacomin, Paul R. "Understanding the mechanism of oxygen sensitivity of SK channels /". Title page and summary only, 2002. http://web4.library.adelaide.edu.au/theses/09SB/09SBg429.pdf.
Texto completoOrfali, Razan. "SK Channel Modulators as Drug Candidates and Pharmacological Tools". Chapman University Digital Commons, 2018. https://digitalcommons.chapman.edu/pharmaceutical_sciences_theses/1.
Texto completoFerraro, T. "Cellular localisation and function of neuronal SK potassium channels". Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445445/.
Texto completoFransson, Martin y Kristin Nilsson. "Marknadsföringens roll inom ishockeyföreningar : En fallstudie på elitserielaget Södertälje SK". Thesis, University of Kalmar, Baltic Business School, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hik:diva-198.
Texto completoSports Marketing is a growing part in the world of sports today. Our main purpose of this paper was to analyze which role marketing plays for an ice hockey organization in the Swedish elite today. For this study we did a case study research on the Swedish team Södertälje Sportklubb, where we interviewed seven people. In addition to the people in the organizations we chose to interview two sport journalists. This research was made from an organizations point of view and all of the interviews were of qualitative character. We could in our analysis draw clear parallels from the empirical and theoretical data. We could analyze the importance of marketing for Södertälje SK and also some general conclusions for the Swedish Elitserien in ice hockey. In our end discussion we created a model that we called Ice hockey Organizations Moment 22, where we show how the marketing function for the Södertälje SK works, according to our opinion.
Ro, Seungil. "SK channels : distribution, function and regulation in mouse colonic myocytes /". abstract and full text PDF (UNR users only), 2002. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3090879.
Texto completoGábor, Radek. "Aplikace elektroerozivního hloubení při technologii výroby vyměnitelných břitových destiček SK". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2008. http://www.nusl.cz/ntk/nusl-228099.
Texto completoChu, Ka Man Emily. "Desensitisation of the CGRP receptor in SK-N-MC cells". Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487319.
Texto completoMoka, Nagaishwarya, Kelley cross, Marianne Brannon, Janet Lightner, Megan Dycus, William Stone, Victoria Palau y Koyamangalath Krishnan. "Delta-tocotrienol and simvastatin induces differential cytotoxicity and synergy in BRAF wild-type SK-MEL-2 and mutant BRAF SK-MEL-28 melanoma cancer cells". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/215.
Texto completoHancock, Jane M. "Resolving the role of SK channel activation in the mouse heart". Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627925.
Texto completoMontgomery, Jenna Rachel. "Functional properties of recombinant SK channels expressed in tsA-201 cells". Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492617.
Texto completoCostamagna, Alejandra. "El lugar del deseo en los cuentos de Antonio Sk?rmeta". Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/108643.
Texto completoPartiendo de las aproximaciones cr?ticas que examinan el fen?meno literario en di?logo fecundo con sus condiciones de producci?n y consideran que las obras se inscriben ?a veces integr?ndose, a veces resistiendo? en el ?mbito cultural y social que las sostiene, este trabajo se propone explorar la obra cuent?stica de Antonio Sk?rmeta en el contexto de su producci?n inicial. Lo que interesa ac? es revisar la po?tica original y el gesto narrativo de un autor que escoge el cuento como un g?nero eficaz, provechoso y esencialmente comunicativo para producir, seg?n sus propios t?rminos, ?un momento intenso de humanidad?. Lejos de pensar en la literatura como un reflejo inmediato de la sociedad, la propuesta de esta investigaci?n apunta a conectar la obra de Sk?rmeta con aquella concepci?n del mundo que la encauza. Esto supone considerar la escritura como un trabajo transformativo plagado de referencias que, siguiendo a No? Jitrik, se adhiere a cierto ?instrumental ideol?gico que no por internalizado (modas, selectividad de temas o im?genes, etc.) es menos resultado de una previa existencia cultural?. Para Jitrik el acto de escritura ocurrir? siempre desde la ideolog?a. Y desde ella, entonces, tendr? lugar la elecci?n de las t?cnicas aptas para que el trabajo se realice adecuadamente. Los cuentos de Sk?rmeta, en ese sentido, hacen suya la visi?n del mundo propia de una juventud que respira y protagoniza una ?poca de tanto entusiasmo y apertura como incertidumbre hist?rica. En efecto, 1967 no s?lo fue el a?o del debut en la narrativa de este escritor chileno nacido en 1940, sino tambi?n un momento clim?tico en el desarrollo cultural de Occidente, marcado por las invocaciones de una juventud en emergencia. Durante la alborotada d?cada del sesenta, por decirlo as?, confluyeron las aguas de una riqu?sima corriente de sensibilidades que se manifestaron en lo que Susan Sontag designar?a entonces como una ?voracidad de entusiasmos?. Los cuentos que aqu? estudiaremos (en el tercer cap?tulo de esta investigaci?n) se alojan en la atm?sfera plena de estos cambios en la metr?poli, en la regi?n latinoamericana y en nuestro pa?s, lo que entre otras cosas implica una ruptura formal y de contenidos con la producci?n literaria inmediatamente previa, la de la generaci?n del cincuenta, marcada en gran medida por la sensibilidad de postguerra y el pesimismo que le sobrevino como una cortina de acero. Y en Chile y en nuestra literatura, adem?s, por la ruptura frente al anquilosado criollismo de los a?os treinta y cuarenta, vigente todav?a en las letras locales. Tal como apunta el cr?tico Jos? Promis, los autores del cincuenta fueron ?testigos del resquebrajamiento del espacio social en que estaban insertos?. Con marcado talante individualista, los j?venes escritores de aquellos a?os dieron cuenta de la angustia vital que los aquejaba a trav?s de im?genes apocal?pticas, de un mundo cerrado y sin salida, ?frente al cual la ?nica respuesta posible, o quiz?s la m?s f?cil de asumir, era el escepticismo?. En este contexto, tal vez la pieza clave de la ?poca haya sido el libro de cuentos La dif?cil juventud, de Claudio Giaconi, que a partir de los inquietantes versos de Nicanor Parra citados en el ep?grafe (?Me preguntaron que de d?nde ven?a/ Contest? que s?, que no ten?a planes determinados/ Contest? que no, que de ah? en adelante?) fij? las coordenadas de lo que Antonio Avaria denominar?a acertadamente ?la anatom?a de la abulia?. Pero si el temple an?mico imperante en estos cuentistas fue el del hast?o, la atm?sfera de la d?cada siguiente ?la que nos interesa revisar en este trabajo? ser? la opuesta y corresponder?, como ya dijimos, al horizonte hist?rico de buena parte del mundo occidental. El arrojo y la vitalidad, as? como el ?nimo comunitario, la incorporaci?n de la cultura popular y del habla de la calle, el ?nfasis en la cotidianeidad y la disposici?n al goce, marcar?n la ruta de los narradores del sesenta. Especialmente de los veintea?eros, como el propio Antonio Sk?rmeta y sus cong?neres de la llamada nov?sima generaci?n o generaci?n del postboom. M?s all? de las etiquetas, sin embargo, la mirada de estas obras no estar? puesta en el individuo pesaroso ni en su atormentada existencia, sino m?s bien en los movimientos de hombres y mujeres que nacen, viven, leen, comen, bailan, fornican, viajan y tambi?n mueren. Seres que se configuran como una pluralidad. Si Giaconi parafraseaba la idea de Tolstoi, cuestion?ndola, cuando dec?a que era necesario describir bien el alma de la propia aldea para ser universal, es posible admitir que la tendencia de la d?cada siguiente ser? regresar al cuerpo colectivo de esa misma aldea, a su atm?sfera extasiada que movilizar? tanto al individuo como a la sociedad en su conjunto, para ser todav?a m?s universales.
Deng, Zhihui. "SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM (SK) CHANNELS IN MAMMALIAN SPINAL MOTONEURONS". Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1237821684.
Texto completoJerresand, Daniel y Mats Johansson. "Elitlicensen : En studie i fallet med Örebro SK och problematiken kring kontrollbalansräkningen". Thesis, Södertörn University College, School of Business Studies, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-143.
Texto completoFör att skydda fotbollens rykte och anseende satte det europeiska fotbollsförbundet UEFA ekonomiska krav på de nationella fotbollsförbunden. Utfärdad av det Svenska Fotbollsförbundet infördes därför år 2001 den s.k. Elitlicensen i svensk fotboll, gällande Allsvenskan och Superettan för herrar samt Damallsvenskan.
Elitlicensen sätter ett antal krav på klubbarna, med största vikt på att det egna kapitalet i föreningen inte får vara negativt, och att påföljden om detta inte uppfylls blir att föreningen tvångsnedflyttas en division. Örebro SK blev den första allsvenska klubb som tvingades ned en division pga. negativt eget kapital. Beslutet var dock långt ifrån okomplicerat och Örebro SK överklagade fotbollsförbundets beslut i tre instanser men fick avslag av alla tre.
Syftet med den här uppsatsen är att studera hur Örebro SK, Licensnämnden, Riksidrottsnämnden och Appellationsnämnden gick tillväga när dom hanterade och gjorde sin bedömning i fallet med Örebro SK:s elitlicens. Vi vill med denna uppsats se vilka regler som finns tillgängliga och ifall dom i detta fall med Örebro SK i nämndernas beslut efterföljdes på ett korrekt sätt. Fanns det en grund i gällande regler för besluten eller handlade det om tolkningsfrågor där man lika gärna hade kunnat ge Örebro SK rätt? Resultatet av fallet kom att handla om tre huvudpunkter, sakkunnigheten i Appellationsnämnden, spelartruppens bokförda värde och en fjärrvärmeskuld till kommunen. Tolkningarna i dessa frågor skiljer sig mellan nämndernas beslut och det finns regelmässiga grunder som gör det möjligt att ta ställning för båda sidor i detta fall vilket bara bevisar exakt hur svårbedömt det här fallet var. Riksidrottsnämnden avslog Örebro SK:s överklagande och flyttade ner klubben till Superettan men den här rapporten visar att man lika gärna hade kunnat ge ÖSK rätt och därmed låtit dom fortsätta spela allsvensk fotboll. Det hade sannolikt lett till minst lika stora reaktioner och diskussioner som nu blev fallet, men en sak hade ändå varit säker.
Istället för ett allsvenskt lag med balanserad ekonomi i Superettan, hade vi idag haft ett allsvenskt lag med balanserad ekonomi i Allsvenskan. Är det inte det som det Svenska Fotbollsförbundet i slutändan strävar mot att ha?
Johansson, Nylander Per, Sebastian Nilsen y Pontus Röstlund. "Fotbollens intressenter En fallstudie av bolagiserade fotbollsklubbarna Djurgårdens IF och Örebro SK". Thesis, Örebro universitet, Handelshögskolan vid Örebro Universitet, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44733.
Texto completoBrom, Josef. "Komparace marketingových strategií SK Dynamo České Budějovice a FK Olympie Týn nad Vltavou". Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-201576.
Texto completoSOARES, Paula Roberta Otaviano. "Atividade Antiproliferativa de Benzaldeído Canfeno Tiossemicarbazonas em Células de Melanoma Humano (SK-MEL-37)". Universidade Federal de Goiás, 2008. http://repositorio.bc.ufg.br/tede/handle/tde/1274.
Texto completoThe thiosemicarbazones are chemical compounds of considerable scientific interest due to their important biological properties, such as antitumoral, antibacterial, antiviral, and antiprotozoal, among others. The studied compounds have the natural monoterpene camphene in the R4 position and the benzaldehyde in R2, with the substitution in the ring for different (R) groups, making this work unique. In this way, thirteen different compounds were derived from the benzaldehyde camphene thiosemicarbazone: camphene isotyiocyanate, camphene thiosemicarbazide, benzaldehyde camphene thiosemicarbazone, p-metyl benzaldehyde camphene thiosemicarbazone, p-methoxy benzaldehyde camphene thiosemicarbazone, o-chloro benzaldehyde camphene thiosecarbazone, m-chloro benzaldehyde camphene thiosemicarbazone, p-chloro-benzaldehyde camphene thiosemicarbazone, o-nitrobenzaldehyde camphene thiosemicarbazone, m-nitro- benzaldehyde camphene thiosemicarbazone, p-nitrobenzaldehyde camphene thiosemicarbazone, p-dimetylamino benzaldehyde camphene thiosemicarbazone and p-hydroxy benzaldehyde camphene thiosemicarbazone. The experiments were conducted in vitro using human melanoma cells (SK-Mel-37), because the melanoma is the most serious type of skin cancer due to its high possibility to metastasize and its resistance to the induction of apoptosis by antineoplastic drugs. We first performed a visual screening to observe if there was detachment of more than 85% of the total number of cells, after treatment with the sole concentration of 100 μM. Thus, six compounds were selected: benzaldehyde camphene thiosemicarbazone, m-chloro benzaldehyde camphene thiosemicarbazone, m-nitro-benzaldehyde camphene thiosemicarbazone, p-dimetylamino benzaldehyde camphene thiosemicarbazone, p-hydroxy benzaldehyde camphene thiosemicarbazone e p-methoxy benzaldehyde camphene thiosemicarbazone. The morphological analysis of the treated cells, by inverted phase contrast microscope and Giemsa stain, showed intense cellular vacuolization and nuclear fragmentation. In the cellular viability test, through the MTT colorimetric assay, the compounds showed IC50 (inhibitory concentration for 50% of the cells) values between 12, 84 μM and 32, 18 μM, which are bellow of those described in the literature for compounds with antineoplastic action. The analysis of nuclear fragmentation by fluorescence microscopy was performed by the incorporation of propidium iodide, and it was observed, at different time points, a progressive increase of cellular damage and a pronounced nuclear fragmentation after the cellular detachment. The analysis of the DNA fragmentation by agarose gel electrophoresis revealed that the unequivocal cytotoxic action of the compounds occurred by apoptosis. Our results showed that six compounds derived from the benzaldehyde camphene thiosemicarbazones had cytotoxic activity in human melanoma cells (SK-Mel-37) in vitro, and constitute potential candidates for future analysis aiming its therapeutic application.
As tiossemicarbazonas são compostos de considerável interesse científico devido às suas importantes propriedades biológicas, tais como antitumoral, antimicrobiana, antiviral, antiprotozoária, dentre outras. Os compostos estudados apresentam o monoterpeno natural canfeno na posição R4 e o benzaldeído em R2, com substituição no anel por diferentes grupos (R), o que confere ao presente trabalho um caráter inédito. Dessa forma, foram apresentados para este estudo onze diferentes compostos derivados de benzaldeído canfeno tiossemicarbazona: benzaldeído canfeno tiossecarbazona, p-metil benzaldeído canfeno tiossemicarbazona, p-metóxi benzaldeído canfeno tiossemicarbazona, o-cloro benzaldeído canfeno tiossemicarbazona, m-cloro benzaldeído canfeno tiossemicarbazona, p-cloro benzaldeído canfeno tiossemicarbazona, onitro benzaldeído canfeno tiossemicarbazona, m-nitro benzaldeído canfeno tiossemicarbazona, p-nitro benzaldeído canfeno tiossemicarbazona, p-dimetilamino benzaldeído canfeno tiossemicarbazona e p-hidróxi benzaldeído canfeno tiossemicarbazona, além de isotiocianato canfeno e canfeno tiossemicarbazida. Os experimentos foram realizados in vitro utilizando-se células de melanoma humano (SKMel- 37), visto que o melanoma é o tipo mais grave de câncer de pele devido à sua alta possibilidade de metástase e resistência à indução de apoptose por drogas antineoplásicas. Inicialmente, realizamos um screening visual observando-se o desprendimento de mais de 85% do total das células, após tratamento com a concentração única de 100 μM. Dessa análise, foram selecionados seis compostos: benzaldeído canfeno tiossemicarbazona, mcloro- benzaldeído canfeno tiossemicarbazona, m-nitro-benzaldeído canfeno tiossemicarbazona, p-dimetilamino-benzaldeído canfeno tiossemicarbazona, p-hidróxibenzaldeído canfeno tiossemicarbazona e p-metóxi benzaldeído canfeno tiossemicarbazona. A análise morfológica das células tratadas e coradas com Giemsa e observadas através de microscópio óptico invertido em contraste de fase demonstrou intensa vacuolização celular e fragmentação nuclear. Na análise da viabilidade celular, através do ensaio colorimétrico do MTT, os compostos apresentaram valores de IC50 (Concentração Inibitória para 50% das células) entre 12,84 μM e 32,18 μM, valores que se encontram abaixo do descrito na literatura para compostos com ação antineoplásica. A análise da fragmentação nuclear através de microscopia de fluorescência foi realizada pela incorporação de iodeto de propídio. Observamos, em diferentes tempos, o aumento progressivo dos danos celulares e a fragmentação nuclear pronunciada após o desprendimento das células. A análise de fragmentação de DNA por eletroforese em gel de agarose revelou de maneira inequívoca que a ação citotóxica observada ocorre por apoptose. Os resultados obtidos demonstraram que seis compostos derivados do benzaldeído canfeno tiossemicarbazonas apresentaram atividade citotóxica em células de melanoma humano (SK-Mel-37) in vitro, e são candidatos promissores para as análises futuras visando à sua aplicação terapêutica.
Marie, Nicolas. "Mécanismes de régulation du récepteur opioi͏̈de delta humain dans le neuroblastome SK-N-BE". Paris 5, 2003. http://www.theses.fr/2003PA05P602.
Texto completoOpiates, such as morphine, are still the most powerful drugs in the management of pain. However, their chronic use induces tolerance, compelling to increase drug dose to obtain the same pharmacological effects and consequently raising the risk of adverse side effects, such as respiratory depression. As m-opioid receptors, d-opioid receptors are involved in analgesia and could participate to the development of tolerance. Accumulating evidence, indicate that tolerance could be initiated by a well-known cell process : desensitization. We conducted our study on the desensitization mechanisms of the human d-opioid receptor, endogenously expressed in the neuroblastoma SK-N-BE cells, activated by distinct opioid agonists. We demonstrated that : - d selective agonists (DPDPE, deltorphin I, SNC-80, AR-M1000390) induced a rapid desensitization (9̃0% for 30 min-pretreatment period) of d opioid receptor compared to non-selective agonists (etorphine, enkephalins) - selective agonists but AR-M1000390, that does not induce receptor sequestration, promoted internalization of d-opioid receptors followed by their degradation in the lysosomal compartment, whereas non-selective agonists induced mainly a recycling after internalization - etorphine-induced desensitization involves PKC and GRK2, while tyrosine kinases are required for desensitization produced by DPDPE and deltorphin. Conclusions : 1 - we demonstrated that d-opioid receptors undergo a differential desensitization, largely depending on the agonist selectivity 2 - the desensitization rate is rather depending on the fate of the opioid receptor, once internalized, than its sequestration from the plasma membrane 3 - the recruitment of different kinases would underlie the differential desensitization induced by selective and non selective agonist
Lebrazi, Jamal. "Etude des effets des activateurs du plasminogène sur les fonctions plaquettaires : aspects fonctionnels et biochimiques". Paris 6, 1994. http://www.theses.fr/1994PA066817.
Texto completoHörmann, Wolfgang y Josef Leydold. "Generating Generalized Inverse Gaussian Random Variates". WU Vienna University of Economics and Business, 2013. http://epub.wu.ac.at/3784/1/Report123.pdf.
Texto completoSeries: Research Report Series / Department of Statistics and Mathematics
Olivo, Valeria. "The role of Gq protein-coupled receptors and SK channels in synaptic NMDA receptor function". Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.658068.
Texto completoBagdonaitė, Agnė. "Pacientų nuomonės ir lūkesčių įvertinimas apie UAB “SK IMPEKS „MEDICINOS DIAGNOSTIKOS CENTRE“ teikiamas reabilitacijos paslaugas". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120607_133746-20297.
Texto completoResearch objective. Assess patients opinions and expectations about „SK Impeks Medicinos Diagnostikos Centre“ provided rehabilitation services. Research tasks. 1) to analyze,,SK Impeks Medicinos Diagnostikos Centre“ provided rehabilitation services; 2) to assess health status of patients visiting ,,SK Impeks Medicinos Diagnostikos Centre“ according to their gender, age; 3) to assess patients‘ opinions and expectations regarding provision of rehabilitation services. Research methodology. During 2011 an anonymous survey of 381 patients from “SK Impeks Medicinos Diagnostikos Centre“ were conducted. Research has been conducted during November and December of 2011 as well as January of 2012. For patients‘ survey an anonymous questionnaire with 36 questions were used. Research data analysis was performed using statistical analisys package SPSS 20.0. Results. There were 338 patients participating in the study: (31,9 proc.) (n =108) – men, (68,0 proc.) (n =230) – women. Assesing the age of respondents the most were 25 – 44 years old (42,0 proc.) and 19 – 24 years old (32,3 proc.), age groups 65 – 74 years and 75 years and older were similar (6,4 proc.) and (5,8 proc.). It was noticed that for men compared to women high quality of personnel was very important (30,5 proc.) and better equipment and materials (13,0 proc.). Women mostly choose: stuff communication (28,6 proc.), time given to patients (7,0 proc.) and shorter visits waiting time (7,4 proc.). Assesing reposndents... [to full text]
Wojdowski, Patrick Stephen 1971. "An X-ray spectroscopic study of the SMC X-1/Sk X-ray binary system". Thesis, Massachusetts Institute of Technology, 1999. http://hdl.handle.net/1721.1/85257.
Texto completoCaplinger, John N. "MematineHCI and Amino-Alkyl-Cyclohexanes (621,625) Inhibit HSV-1 in SK-N-SH Neuronal Cells". Youngstown State University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1007757941.
Texto completoMuge, Rosemary. "Poverty, protest and sport : poaching in the East Midlands, c.1820-1900". Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49161/.
Texto completoAli, Sk Imran [Verfasser] y Sander van [Akademischer Betreuer] Smaalen. "Synthesis, Superstructure, Vacancy-Ordering of Intercalated Transition Metal Dichalcogenides / Sk Imran Ali. Betreuer: Sander van Smaalen". Bayreuth : Universität Bayreuth, 2014. http://d-nb.info/1061071936/34.
Texto completoSchmücker, Helmut. "Resonanzstruktur des Zerfalls D+-1tnS->K°SK°Sp+- [D S K S K S pi]". [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=967681405.
Texto completoWilhelmy, Florian [Verfasser] y Carsten [Akademischer Betreuer] Culmsee. "Die Rolle der SK-Kanäle in alpha-Synuclein-aktivierter primärer Mikroglia / Florian Wilhelmy ; Betreuer: Carsten Culmsee". Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1183909225/34.
Texto completoAndrade, Anderson Cleyton Ferreira de [Verfasser] y Günter [Akademischer Betreuer] Höglinger. "Die Aktivierung von SK-Kanälen in einem Parkinson-Zellmodell / Anderson Cleyton Ferreira de Andrade. Betreuer: Günter Höglinger". Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1064097383/34.
Texto completoNilsson, Hallgren Clara y Moa Ström. ""Även jag kommer bli fri(sk) en vacker dag" : Tonårsflickors upplevelser av att leva med Anorexia nervosa". Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16862.
Texto completoBackground: Anorexia nervosa (AN) is considered one of the most serious mental disorders since the disease is associated with serious complications. The most common age for AN is 14–19 years. Teenage girls with AN experience impaired health and well-being and increased suffering. The nurse's role aims to normalize the bodyweight. Teenage girls needs support and motivation from the nurse. Aim: To describe teenage girls' experiences of living with Anorexia nervosa. Method: Autobiographical blog entries have been analyzed based on a manifest qualitative content analysis with an inductive approach. Results: The result revealed four main categories that include Living in constant conflict with oneself, Living with a changed body, The feeling of mental stress and its consequences and Wanting to be healthy and free. Conclusion: Meeting teenage girls who live with AN can be a difficult experience for the nurse. Furthermore, it is shown that the needs of teenage girls do not correspond to the nurse's role in AN. As a nurse, it is important to look at the needs of teenage girls in order to increase the experience of health and well-being, alleviate suffering and promote recovery.
Allouche, Stéphane. "Le neuroblastome humain sk-n-be comme modele d'etude des recepteurs opioides : caracterisation des voies de transduction". Caen, 1998. http://www.theses.fr/1998CAEN2013.
Texto completoHASBI, AHMED. "Mecanismes de desensibilisation et de resensibilisation des recepteurs opioides delta humains dans le neuroblastome sk-n-be". Caen, 1999. http://www.theses.fr/1999CAEN2013.
Texto completoAbdulkareem, Zana Azeez. "SK potassium and TRPM7 ion channel role in CNS cell survival and breast cancer cell death decisions". Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/80343/.
Texto completoPassos, Débora Cristina Silva dos. "Ação biológica in vitro de tiossemicarbazonas derivadas de canfeno e limoneno em células de melanoma humano (SK-MEL-37)". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3426.
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Melanoma is a type of cancer that arises from melanocytes and is notoriously resistant to radiation and chemotherapy. The thiosemicarbazones are synthetic compounds with marked biological properties such as antibacterial, antiviral, antiprotozoal and antitumor and previous studies have demonstrated cytotoxic activity against the human melanoma cells, so in this study, we evaluated the antiproliferative activity, the enzymatic activity of Caspases 2, 3, 6, 8, 9, the effect on the cell cycle gene expression levels of caspases 2, 3, 6, 8, 9, Apaf-1 and microscopic morphological changes in human melanoma cells (SK -MEL-37) twenty one monoterpene derived from natural thiosemicarbazone (-) - camphene: camphene, benzaldehyde, benzophenone, menthone, ethyl pyruvate, p-nitroacetophenone, pchloroacetophenone, p-methoxyacetophenone, p-methylacetophenone, p fluoracetofenona-phidroxiacetofena, furan, 3-methoxy-4-hydroxybenzaldehyde, p-fluorbenzaldehyde, 2- hydroxybenzaldehyde, cinnamic aldehyde, thiophene-2-carboxaldehyde, 1-H-imidazole-4- carboxaldehyde, tiossemicaroazida and six montoterpeno natural R-(+)-limonene: benzaldehyde, thiosemicarbazide, o-nitro, m-nitro, p-nitro, p-hydroxy and p-dimethylamino. The values found for the inhibitory concentration for 50% of cells (IC50) were between 12 μM and 55 μM. The percentage of cells in phase and in phase G0/G1 decreased SG2 / M increased after forty-eight hours of incubation with benzaldehyde thio-camphene, limonene thio-benzaldehyde, m-nitro, p-hydroxy and thiosemicarbazide increased indicating that the growth inhibitory effect might be also due to arrest of cells at S-G2/M phase. We observed increased activity of caspase 3 (m-nitro thio-limonene), 6 (camphene thio-benzaldehyde and p-hydroxy thio-limonene) and 8 (thio-benzaldehyde limonene). Late apoptotic features were detected in 62% of cells treated with benzaldehyde thio-camphene and morphological changes typical of apoptosis were visualized by fluorescence microscopy and scanning electron microscopy (SEM) after treatment with benzaldehyde thio-camphene chosen due to their low IC50 value (12 mM). It was observed gene expression of caspases 2, 3, 6, 8 and Apaf-1 in cells treated with benzaldehyde thio-camphene indicating the participation of these enzymes in the anti-proliferative effect observed. Our results indicate that the thiosemicarbazones derivatives can inhibit proliferation, regulate cell cycle, induce apoptosis of human melanoma cells (SK-MEL-37) and could be an candidate for future preclinical in vivo studies.
O melanoma é um tipo de câncer que surge nos melanócitos e é notoriamente resistente à radioterapia e quimioterapia. As tiossemicarbazonas são compostos sintéticos com marcantes propriedades biológicas tais como antibacteriana, antiviral, antiprotozoária e antitumoral e em estudos anteriores demonstraram ação citotóxica frente à celulas de melanoma humano, por isso, neste estudo, foi avaliada a atividade anti-proliferativa, a atividade enzimática das caspases 2, 3, 6, 8, 9, o efeito no ciclo celular, os níveis de expressão gênica das caspases 2, 3, 6, 8, 9, Apaf-1 e as alterações morfológicas por microscopia em células de melanoma humano (SK-MEL-37) de vinte e uma tiossemicarbazonas derivadas do monoterpeno natural (-)- canfeno: canfeno, benzaldeído, benzofenona, mentona, etil piruvato, acetofenona, pnitroacetofenona, p-cloroacetofenona, p-metoxiacetofenona, p-metilacetofenona, pfluoracetofenona, p-hidroxiacetofena, furano, 3-metóxi-4-hidroxibenzaldeído, pfluorbenzaldeído, 2-hidroxibenzaldeído, aldeído cinâmico, tiofeno-2-carboxialdeído, 1-Himidazol- 4-carboxialdeído, tiossemicaroazida, bem como seis do montoterpeno natural R-(+)- limoneno: benzaldeído, tiossemicarbazida, o-nitro, m-nitro, p-nitro, p-dimetilamino e phidróxi . Os valores encontrados para a concentração inibitória para 50% das células (IC50) situaram-se entre 12 μM e 55 μM. A porcentagem de células na fase G0/G1diminuiu e na fase SG2/M aumentou após quarenta e oito horas de incubação com o benzaldeído tio-canfeno, benzaldeído tio-limoneno, m-nitro, p-hidróxi e tiossemicarbazida, indicando que o efeito antiproliferativo observado pode ser devido a uma interrupção das células na fase SG2/M. Observou-se uma maior atividade de caspase 3 (m-nitro tio-limoneno), 6 (benzaldeído tiocanfeno e p-hidróxi tio-limoneno) e 8 (benzaldeído tio-limoneno). Características apoptóticas tardias foram detectados em 62% das células tratadas com benzaldeído tio-canfeno e as alterações morfológicas típicas de processo de apoptose foram visualizadas através da microscopia de fluorescência e de microscopia eletrônica de varredura (MEV) após tratamento com o benzaldeído tio-canfeno escolhido devido ao seu baixo valor de IC50 (12 μM). Observou-se a expressão gênica das caspases 2, 3, 6, 8 e o apaf-1 nas células tratadas com benzaldeído tio-canfeno indicando a participação dessas enzimas no efeito antiproliferativo observado. Os resultados indicam que as tiossemicarbazonas derivadas de canfeno e limoneno podem inibir a proliferação celular, regular o ciclo celular e induzir apoptose nas células de melanoma humano (SK-MEL-37), portanto, podem ser considerados candidatos para futuros ensaios pré-clínico in vivo.
Kye, Min-Jeong. "Regulation of small-conductance, calcium-activated potassium channels (SK) in mouse brain in response to aging and stress". [S.l.] : [s.n.], 2004. http://webdoc.sub.gwdg.de/diss/2004/kye/kye.pdf.
Texto completoAsplund, Love. "Från amatörism till professionalism : en undersökning av organisationerna hos Västerås SK ocg Gideonsbergs IF efter amatörismens avskaffande 1967". Thesis, Mälardalen University, Department of Social Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-366.
Texto completoSyftet med undersökningen är att belysa hur två fotbollsföreningar i Västerås påverkats av amatörismens avskaffande 1967. Gideonsbergs IF (damer) och Västerås SK (herrar). Undersökningen har fokus på hur dessa föreningars organisation och budget förändrats i och med professionalismens införande i den svenska idrotten, samt hur föreningarna skaffat sponsorer. Dessutom påvisas de skillnader som funnits mellan föreningarna. Forskningsansatsen är kvalitativ och data har insamlats främst från de båda föreningarnas styrelseprotokoll men även genom en intervju med en person som varit anställd av båda föreningarna under den undersökta perioden. Resultatet blev att tydliga förändringar syntes inom båda föreningarnas budget och organisation efter amatörismens avskaffande. Omsättningen i föreningarna ökade och organisationerna effektiviserades. Likheter och skillnader mellan klubbarna redovisas även.
Drake, W. M. "Desensitisation of calcitonin gene-related peptide of adrenomedullin receptors in vascular smooth muscle of SK-N-MC cells". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275192.
Texto completoPearce, N. J. "Studies on the mechanism of organ selective receptor occupation by the synthetic thyromimetic SK and F L-94901". Thesis, University of London, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383708.
Texto completoOliveira, Antonio Edinardo de. "Uma caracterizaÃÃo do produto Sk (cos θ) x Sn-k (sen θ) na esfera euclidiana S^ (n+1)". Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11689.
Texto completoNeste trabalho consideraremos hipersuperfÃcies n-dimensionais com curvaturas escalar constante na esfera unitÃria S^(n+1). Caracterizaremos as hipersuperfÃcies dadas por produtos de esferas, cuja dimensÃo à n, na esfera unitÃria S^(n+1) e mostraremos que existe vÃrias hipersuperfÃcies compactas com curvaturas escalar constante na esfera unitÃria S^(n+1) que nÃo sÃo congruentes entre si. Em particular, provaremos que se M à uma hipersuperfÃcie n-dimensional (n>3) completa, localmente conformemente plana com curvatura escalar constante n(n-1)r na esfera unitÃria S^(n+1), entÃo r à maior do que um valor prÃ-estabelecido e sÃo provados dois resultados, um envolvendo isometrias e o outro de existÃncia, quando r e S satisfazem determinadas condiÃÃes, onde S à o quadrado da norma se segunda forma fundamental de M.
In this paper we consider n-dimensional hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1). Characterize the hypersurfaces given by products of spheres whose size is n, the unit sphere S ^ (n +1) and show that there is more compact hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1) that are not congruent itself. In particular, prove that M is an n-dimensional hypersurface (n> 3) complete with buckle locally flat accordingly constant scalar n (n-1) on the unit sphere S r ^ (n +1) is greater than r a pre-established and two results are proven value, and the other one involving isometries of existence, when are S satisfy certain conditions, where S is the square of the standard is second fundamental form of M.
Oliveira, Antônio Edinardo de. "Uma caracterização do produto Sk (cos θ) x Sn-k (sen θ) na esfera euclidiana S^ (n+1)". reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/8108.
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In this paper we consider n-dimensional hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1). Characterize the hypersurfaces given by products of spheres whose size is n, the unit sphere S ^ (n +1) and show that there is more compact hypersurfaces with constant scalar curvature in the unit sphere S ^ (n +1) that are not congruent itself. In particular, prove that M is an n-dimensional hypersurface (n> 3) complete with buckle locally flat accordingly constant scalar n (n-1) on the unit sphere S r ^ (n +1) is greater than r a pre-established and two results are proven value, and the other one involving isometries of existence, when are S satisfy certain conditions, where S is the square of the standard is second fundamental form of M.
Neste trabalho consideraremos hipersuperfícies n-dimensionais com curvaturas escalar constante na esfera unitária S^(n+1). Caracterizaremos as hipersuperfícies dadas por produtos de esferas, cuja dimensão é n, na esfera unitária S^(n+1) e mostraremos que existe várias hipersuperfícies compactas com curvaturas escalar constante na esfera unitária S^(n+1) que não são congruentes entre si. Em particular, provaremos que se M é uma hipersuperfície n-dimensional (n>3) completa, localmente conformemente plana com curvatura escalar constante n(n-1)r na esfera unitária S^(n+1), então r é maior do que um valor pré-estabelecido e são provados dois resultados, um envolvendo isometrias e o outro de existência, quando r e S satisfazem determinadas condições, onde S é o quadrado da norma se segunda forma fundamental de M.
Gettová, Zuzana. "Bezpečnost práce a pracovní úrazy ve stavebnictví". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2017. http://www.nusl.cz/ntk/nusl-265492.
Texto completoGómez-Bofill, Walter. "Über einparametrische Optimierungsprobleme (spezielle Einbettungen) und einparametrische Variationsgleichungen". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 1999. http://dx.doi.org/10.18452/14358.
Texto completoWe consider two types of one-parametric problems: optimization problems and variational inequalities. Both are studied in relationship with the regularity approach due to Jongen, Jonker and Twilt (JJT-regularity), which was defined initially only for one-parametric optimization problems. The properties of two special embeddings are analysed under the assumption of JJT-regularity. Given an optimization problem P, the first embedding analysed is defined with use of an interior point of the feasible set. It holds for this embedding, that the parametric feasible set for tglobal approach. Statements concerning the existence of solution curves connecting problems (for instance t=0 and t=1) under the defined regularity are studied in the last section. The consideration of JJT-regularity for the case of variational inequalities is a new and usefull aspect for the study of this problem.