Tesis sobre el tema "Sialic Acid Binding Proteins"
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Alias, Nadiawati. "Multivalent sialic acid binding proteins as novel therapeutics for influenza and parainfluenza infection". Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/4479.
Texto completoHopkins, Adam P. "Molecular and biochemical characterisation of SiaP as a sialic acid binding protein component of a TRAP transporter of sialic acid". Thesis, University of York, 2010. http://etheses.whiterose.ac.uk/1030/.
Texto completoJiménez-Castells, Carmen 1982. "Capture and identification of carbohydrate-binding proteins by SPR and CREDEX-MS". Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7237.
Texto completoLas lectinas (proteínas de origen no inmune capaces de reconocer azúcares) se han revelado en las últimas décadas como participantes cruciales en multitud de procesos biológicos, tales como la comunicación célula-célula, la fertilización, la adhesión del patógeno a la célula y la metástasis, entre muchos otros. Por lo tanto, existe un gran interés en el desarrollo de técnicas analíticas potentes para el estudio de las interacciones lectina-carbohidrato. En este trabajo, se describen dos aproximaciones complementarias mediante las cuales se pueden caracterizar las interacciones lectinas-azúcar con gran sensibilidad, poca utilización de muestra y sin la necesitad de ningún marcaje. En la técnica basada en resonancia de plasmón superficial (SPR), el azúcar es inmovilizado sobre una superficie a través de un módulo peptídico, lo cual permite (1) capturar la lectina, (2) caracterizar su interacción mediante parámetros cinéticos y termodinámicos y (3) identificar posteriormente la proteína mediante espectrometría de masas. Complementariamente, la técnica CREDEX-MS, basada en la excisión proteolítica del complejo proteína-azúcar y posterior análisis por espectrometría de masas, nos permite identificar los péptidos que forman parte del dominio de unión al azúcar.
Zhang, Mai. "Exploring the effect of sialic acid binding properties on Siglec function /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190162.
Texto completoFreeman, Sylvie. "Studies on CD33 and sialoadhesin : sialic acid binding receptors of the haemopoietic system". Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318544.
Texto completoCiccotosto, Silvana. "The preparation and evaluation of N-acetylneuraminic acid derivatives as probes of sialic acid-recognizing proteins". Monash University, Dept. of Medicinal Chemistry, 2004. http://arrow.monash.edu.au/hdl/1959.1/9649.
Texto completoYao, Yujing [Verfasser]. "Influence of sialic acid modification on HIV GP120 binding and Syncytia formation / Yujing Yao". Berlin : Freie Universität Berlin, 2018. http://d-nb.info/1176639129/34.
Texto completoToro, Imre. "Crystal structures of two nucleic acid-binding proteins". Thesis, Open University, 2000. http://oro.open.ac.uk/58089/.
Texto completoShum, Bennett Oh Vic St Vincent's Clinical School UNSW. "Regulation of allergic asthma by fatty acid-binding proteins". Awarded by:University of New South Wales. St. Vincent's Clinical School, 2007. http://handle.unsw.edu.au/1959.4/27002.
Texto completoRowlinson, Marie-Claire. "The fatty acid and retinol binding proteins of nematodes". Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289452.
Texto completoCRACCO, Laura. "Fatty acid-binding proteins as markers of brain injury". Doctoral thesis, Università degli Studi di Verona, 2009. http://hdl.handle.net/11562/337348.
Texto completoFatty acid–binding proteins (FABPs) are abundant intracellular proteins that bind long-chain fatty acids with high affinity. 9 different FABPs, with tissuespecific distribution, have been identified so far. The primary role of all the FABP family members is regulation of fatty acid uptake and intracellular transport. Heart-type FABP (H-FABP) is considered one of the most sensible and efficient markers of heart and brain damage, but to date the cross-reactivity limits its specific use. Brain-type FABP (B-FABP) might be considered as a good marker of brain damage, being expressed only in the nervous tissue. The aim of this work was to generate a diagnostic reagent specific for human B-FABP, not cross-reacting with H-FABP. The work has been articulated in two parts: in the first one, recombinant protein B-FABP was expressed in E. coli cells and purified by two subsequent chromatographies. The protein was then utilized as immunogen in New Zealand rabbits and BalbC mice, obtaining two antisera and 8 different hybridoma cells. The antibodies in the rabbit serum and in culture supernatant of hybridoma cells displayed different degrees of affinity for B-FABP and H-FABP; only one hybridoma cell was able to produce antibodies specific and selective for brain-type FABP, but the antibody low-titer level and the activity decrease after subsequent subcloning steps affected its application on B-FABP detection in biological fluids. To overcome the limits encountered in the first part of work, a computer-assisted approach on B-FABP was employed in order to identify the potentially most antigenic regions of the protein. Two synthetic peptides were produced with the selected sequences and inoculated in rabbits. Two polyclonal antibodies were obtained, pAb 2979/2980 and pAb 2981/2982. They showed specific and selective reactivity for human B-FABP, without crossreactions with H-FABP. Taken together, our experimental approach was effective for the generation of specific α-B-FABP antibodies; these results suggest the antibodies obtained could be utilized in ELISA and immunoblot analyses in order to value B-FABP as marker of neurological disorders with ischemic, infective and degenerative etiology.
Abu-Izneid, Tareq y n/a. "The Synthesis and Evaluation of Functionalised Carbohydrates as Probes of Tumour Metastasis". Griffith University. Institute for Glycomics, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20061019.111424.
Texto completoAbu-Izneid, Tareq. "The Synthesis and Evaluation of Functionalised Carbohydrates as Probes of Tumour Metastasis". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367269.
Texto completoThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Full Text
Claude, Janine [Verfasser]. "The implication of microglial sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) in neuroinflammation / Janine Claude". Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1049984579/34.
Texto completoZhu, Danni. "Characterization of nicotinic acid adenine dinucleotide phosphate (NAADP) binding proteins". Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:cb3309e7-ad14-4c0b-a24c-c42d95b52845.
Texto completoMussabekova, Assel. "Evaluating antiviral activity of nucleic acid binding proteins across species". Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ006.
Texto completoAntiviral response largely relies on the recognition of viral nucleic acids. The aim of the project was to characterize the range of nucleic acid binding proteins in the context of viral infection in flies. We identified a wide repertoire of proteins, which recognize viral nucleic acids in five species (human, mouse, chicken, fruit fly and roundworm). Among these proteins, there are ones, which are conserved in insects and humans, and therefore their function can be easily studied in the fruit fly model. Afterwards, we have performed a large screen in flies to study more precisely the function of 100 proteins in infection with 5 different viruses. We have found eight promising candidates as a result of this screen. We identified two Drosophila proteins CG5641 and Zn72D, which are also present in humans, as proviral factors. We also identified a protein Tao, which is conserved in humans, and is antiviral against several types of viruses
Torchia, Enrique C. "The role of intracellular bile acid binding proteins in bile acid transport and cytoprotection". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60354.pdf.
Texto completoKopatz, Jens Christopher [Verfasser]. "Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation / Jens Christopher Kopatz". Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1081423676/34.
Texto completoKopatz, Jens [Verfasser]. "Microglial sialic-acid-binding immunoglobulin-like lectin-H (Siglec-H) and Siglec-11 in neuroinflammation / Jens Christopher Kopatz". Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1081423676/34.
Texto completoSo, Po-Lin. "The role of cellular retinoic acid binding proteins in zebrafish embryogenesis". Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264167.
Texto completoReinhart, Gregory Allen. "Nutrient regulation and developmental expression of porcine fatty acid binding proteins /". The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267728138.
Texto completoAldhamen, Yasser A. "All-trans retinoic acid downregulates CCAAT/enhancer binding proteins in human bronchial epithelial cells". Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1187302036.
Texto completo"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 37-48, 62-84.
Nieuwenhoven, Franciscus Arnoldus van. "Heart fatty acid-binding proteins role in cardiac fatty acid uptake and marker for cellular damage /". Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6268.
Texto completoCampbell, Fiona M. "Long-chain fatty acid transport by the human placenta : the role of fatty acid-binding proteins". Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363738.
Texto completoRobertson, Timothy Allen. "Development and validation of statistical potential functions for the prediction of protein/nucleic-acid interactions from structure /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9268.
Texto completoLi, Huiying. "Adipocyte fatty acid-binding protein : a link between inflammation and vascular dysfunction /". Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B44248714.
Texto completoLi, Huiying y 李慧颖. "Adipocyte fatty acid-binding protein: a link between inflammation and vascular dysfunction". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44248714.
Texto completoErol, Erdal. "Heart- and liver-type fatty acid binding proteins in lipid and glucose metabolism". Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/1148.
Texto completoKrisinger, Michael J. "Membrane binding properties of prothrombin and other gamma-carboxyglutamic acid-containing coagulation proteins". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31087.
Texto completoMedicine, Faculty of
Biochemistry and Molecular Biology, Department of
Graduate
Kokorelis, Steve H. "Biochemical Analysis of Putative Single-Stranded Nucleic Acid Binding Proteins in Porphyromonas gingivalis". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4833.
Texto completoSeyfried, Nicholas T. "The structure and function of hyaluronan-binding proteins in extracellular matrix assembly". Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:e1a2cf8f-7ac7-4c5a-bd3f-53d7653e8888.
Texto completoSmith, Nicholas James. "The clinical utility of FABP in acute coronary syndromes". Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391403.
Texto completoChan, Cangel Pui Yee. "A superior early myocardial infarction marker : human heart-type fatty acid-binding protein /". View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?CHEM%202002%20CHAN.
Texto completoIncludes bibliographical references (leaves 139-166). Also available in electronic version. Access restricted to campus users.
Sauer, Anne-Kathrin [Verfasser]. "Analysis of the sialic acid binding activity of the hemagglutinins of influenza viruses and its role in host tropism / Anne-Kathrin Sauer". Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1037878744/34.
Texto completoNadassy, Katalin. "Molecular recognition by proteins : structural features of zinc and protein-nucleic acid binding sites". Thesis, University of Stirling, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341227.
Texto completoBrailsford, Louis Alex. "Investigating the possible role of fatty acid binding proteins (FABPs) in nociceptive pain processing". Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/44886/.
Texto completoAldhamen, Yasser. "All-trans retinoic acid downregulates CCAAT/enhancer binding proteins in human bronchial epithelial cells". University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1187302036.
Texto completoRuberte, Esther. "Retinoic acid receptors and cellular retinoid binding proteins : their transcript distribution during mouse embryogenesis". Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13009.
Texto completoPetrescu, Anca Daniela. "Ligand binding proteins: roles in ligand transfer and activation of nuclear receptors". Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/290.
Texto completoYeung, Chun-yu. "Adipocyte- and epidermal-fatty acid-binding proteins in relation to obesity and its medical complications". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B44204565.
Texto completoWong, Tak-sui y 黃德緒. "Adipocyte fatty acid binding protein acts as a suppressor of autophagy contributing to foam cell formation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206502.
Texto completopublished_or_final_version
Medicine
Master
Master of Medical Sciences
Ploskon-Arthur, Eliza. "Binding of intermediates by type 1 and type 11 fatty acid synthase acyl carrier proteins". Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521059.
Texto completoYeung, Chun-yu y 楊振宇. "Adipocyte- and epidermal-fatty acid-binding proteins in relation to obesity and its medical complications". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B44204565.
Texto completoRoundell, Jennifer. "Cellular retinoic acid binding protein (CRABP) mRNA expression in splotch mutant mouse embryos". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27397.
Texto completoGarza, John Anthony. "Structural and ligand-binding properties of a dual substrate specific enzymes from schizosaccharomyces pombe a dissertation /". San Antonio : UTHSC, 2009. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=45&CISOBOX=1&REC=17.
Texto completoPeet, Daniel J. "Protein-bound fatty acids in mammalian hair fibres /". Connect to thesis, 1994. http://eprints.unimelb.edu.au/archive/00000641.
Texto completoWong, Yue-ling y 黃愉鈴. "The role of adipocyte fatty acid binding protein in the pathogenesis of non-alcoholic fatty liver disease". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45164873.
Texto completoPowell, Catherine. "The Roles of Metabolic Proteins, Fatty Acid Binding Protein 5 and S100A7, in Breast Cancer and Obesity". The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1426179329.
Texto completoKemp, Hilary A. "A complex of six FAR proteins required for pheromone arrest and mating /". view abstract or download file of text, 2003. http://wwwlib.umi.com/cr/uoregon/fullcit?p3113011.
Texto completoTypescript. Includes vita and abstract. Includes bibliographical references (leaves 94-104). Also available for download via the World Wide Web; free to University of Oregon users.
Pedersen, Sindre Andre. "Metal binding proteins and antifreeze proteins in the beetle Tenebrio molitor : a study on possible competition for the semi-essential amino acid cysteine". Doctoral thesis, Norwegian University of Science and Technology, Department of Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1504.
Texto completoIn their natural environment animals are confronted by both physical (eg. extreme temperatures, desiccation) and chemical stressors (e.g. pollutants). Stress may be defined as a condition that is evoked in an organism by one or more environmental factors that bring the organism near to or over the edges of its ecological niche (van Straalen 2003). Various defence systems exist to cope with different forms of stress and restore homeostasis. Often, production of various proteins or enzymes are involved in these defence systems (Korsloot et al. 2004). Since an organism’s resources may be considered to be limited, the ability to restore homeostasis depends on the severity of the different forms of stress it experiences. It has been proposed that pollutants present in the environment may alter the ability to respond to climatic stressors like e.g. low temperature, desiccation (Holmstrup 2002).
This work deals with the possible consequences of combined stress from metal exposure and low temperature in cold hardy insects. Many of these insects produce so called antifreeze proteins that protect them from lethal freezing. Metallothioneins are metal binding proteins that are considered to be important in detoxification when animals are exposed to metals. Metallothioneins and most forms of antifreeze proteins from insects are known to contain unusually high amounts cysteine. Cysteine is considered to be semi-essential, since it must be derived from the essential amino acid methionine (Choen 2004). Induction of one of these two types of proteins may potentially deplete the cysteine pool and thus reduce the capacity to produce the other type. Alternatively, the animals might have evolved other structures to avoid a potential competition for cysteine. The purpose of the present work was to explore these possible scenarios.
Paper I and II reprinted with kind permission of Elsevier, Sciencedirect.com