Tesis sobre el tema "Sensomic"
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Daher, Dahlia. "Développement d’hydrolysats caséiques innovants par voie biotechnologique". Electronic Thesis or Diss., Université de Lille (2018-2021), 2021. http://www.theses.fr/2021LILUR057.
Texto completoEnzymatic hydrolysis of proteins is used in the food industry to improve their techno-functional properties such as solubility, emulsification but also for the various nutritional properties of hydrolysates. Indeed, protein hydrolysates are characterized by a remarkable digestive tolerance, a decrease in allergenicity, a reinforcement of bioavailability and bioactivity. Therefore, they are used in nutrition market such as infant, clinical and sport nutrition. Protein hydrolysate properties are determined by the structure of peptides produced. These depend on i) the nature of native proteins hydrolysed, ii) the specificity of the enzyme or enzymes cocktails and on iii) the hydrolysis conditions (pH, temperature, hydrolysis time). One of the main problems of protein hydrolysis is that it affects the flavour and taste (especially bitterness of the hydrolysates). The main aim of this work was to obtain a hydrolysate with as little bitterness and "off-flavors" as possible, but also to better understand the causes of this bitterness, using biostatistical tools such as random forests. The second aim was to build a tool for predicting the bitterness of a hydrolysate according to the structure and nature of the amino acids of the peptides
Olsson, Linn. "9 actions - Sensoric Measures for Eternal Efficiency". Thesis, Konstfack, Inredningsarkitektur & Möbeldesign, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-7973.
Texto completoSpohn, Peter Karl. "Grundlagen der Gitterkoppler-Sensorik /". [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=9864.
Texto completoGerlach, Gerald. "Dresdner Beiträge zur Sensorik". Technische Universität Dresden, 2017. https://tud.qucosa.de/id/qucosa%3A26134.
Texto completoSince 1996 the book series „Dresdner Beiträge zur Sensorik“ edited by Prof. Dr.-Ing. habil. Gerald Gerlach has been published. The aim of this series is the publication of outstanding scientific contributions of TU Dresden, especially of those compiled at the Institute for Solid-State Electronics. The Solid-State Electronics Laboratory (Institut für Festkörperelektronik - IFE) is one of 12 laboratories of the Electrical and Computer Engineering Department at Technische Universität Dresden. Together with the Semiconductor Technology and Microsystems Lab and several chairs of the Circuits and Systems and the Packaging Labs, the Solid-State Electronics Laboratory is responsible for the microelectronics specialization in the Electrical Engineering program. Research and teaching field of the Institute for Solid-State Electronics are dedicated to the interaction of physics, electronics and (microelectronics) technology in: materials research, technology, and solid state sensor operational principles, application of sensors for special measurement problems, design of sensors and sensor systems including the simulation of components as well as of complex systems, development of thin films and multilayer stacks for sensor applications, application of ultrasound for nondestructive evaluation, medical diagnostics and process measurement technology.
Grünker, Ronny. "Hochporöse und flexible metallorganische Gerüstverbindungen basierend auf Stickstoff-haltigen Carboxylat-Liganden". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-104535.
Texto completoLöhmannsröben, Hans-Gerd, Zoltan Kantor, Michael U. Kumke, Elmar Schmälzlin y Oliver Reich. "OPQS – optische Prozess- und Qualitäts-Sensorik". Universität Potsdam, 2005. http://opus.kobv.de/ubp/volltexte/2007/1320/.
Texto completoSchwarz, Daniel [Verfasser]. "Fußgängerschutz durch kooperative Sensorik / Daniel Schwarz". Aachen : Shaker, 2010. http://d-nb.info/1080766782/34.
Texto completoKlöden, Horst [Verfasser]. "Fahrzeugsicherheit durch kooperative Sensorik / Horst Klöden". München : Verlag Dr. Hut, 2014. http://d-nb.info/1050331702/34.
Texto completoKamp, Bernhard. "Beiträge zur Sensorik redox-aktiver Gase". [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10316303.
Texto completoLunardi, Giulia <1990>. "Sviluppo di sensori voltammetrici enantioselettivi". Master's Degree Thesis, Università Ca' Foscari Venezia, 2016. http://hdl.handle.net/10579/7703.
Texto completoGIORDANI, MARTINA. "Sensori Neuromorfici Organici per Neurotrasmettitori". Doctoral thesis, Università degli studi di Modena e Reggio Emilia, 2020. http://hdl.handle.net/11380/1211520.
Texto completoIn this thesis an ultra-sensitive and selective sensor for dopamine (DA) by means of a neuro-inspired device platform without the need of a specific recognition moiety is demonstrated. DA is a neurotransmitter of catecholamines family that controls functions of cardiovascular, renal, hormonal and central nervous systems. DA deficit is a hallmark of Parkinson’s disease (PD), due to the degeneration of dopaminergic neurons in substantia nigra pars compacta. The sensor is a whole organic device featuring two electrodes made of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate – PEDOT:PSS – directly patterned through laser ablation on a polydymethylsiloxane – PDMS – flexible substrate. One electrode is pulsed with a train of voltage square waves (-200 mV with a frequency of 500 Hz for 1s), to mimic the pre-synaptic neuron behavior, while the other is used to record the displacement current, mimicking the post-synaptic neuron. The current response exhibits the features of synaptic Short-Term Plasticity (STP) with facilitating or depressing response according to the stimulus frequency. We found that the resulting current decreases with a characteristic time, τSTP , depending on DA concentration in solution. The sensor detects [DA] down to 1 pM range. We assess the sensor also in the presence of several moieties physiologically present in cerebrospinal fluid or extracellular fluids, i.e. ascorbic acid, uric acid, 3-methoxytyramine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, epinephrine and norepinephrine. Our detection strategy successfully discriminates DA from the other analytes in model solutions (i.e. Phosphate Saline Buffer). The sensor appears still more sensitive to DA than to the others, even in presence of moieties with similar chemical structures. The synapse appears ultrasensitive to DA (from physiological to pathological concentrations) and selective thanks to the interaction mechanism with PEDOT:PSS. DFT calculations on PEDOT:PSS/metabolite clusters hint to a correlation between the STP response and stronger non-covalent interactions between DA and PEDOT:PSS, specifically electrostatic and hydrogen bonding of DA ammonium end group with sulfonate. The whole organic synapse, being biocompatible, soft and flexible, is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids, to be used as a diagnostic tool, for instance, in chronic neurodegenerative diseases such as Parkinson’s disease.
Shin, Jung-Bum. "Identification of genes involved in sensory neuron mechanotransduction". [S.l. : s.n.], 2002. http://www.diss.fu-berlin.de/2003/68/index.html.
Texto completoBlum, Carsten. "Analytik und Sensorik von Gewürzextrakten und Gewürzölen". [S.l. : s.n.], 1999. http://www.sub.uni-hamburg.de/disse/57/DrBlum.pdf.
Texto completoStürzl, Wolfgang. "Sensorik und Bildverarbeitung für Landmarken-basierte Navigation". [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971046514.
Texto completoBöhringer, Frank. "Gleisselektive Ortung von Schienenfahrzeugen mit bordautonomer Sensorik". Karlsruhe Univ.-Verl. Karlsruhe, 2008. http://d-nb.info/98954947X/04.
Texto completoFörster, Christian Ambacher Oliver. "Mikro- und nanoelektromechanische Resonatoren für die Sensorik /". Aachen : Shaker, 2006. http://www.gbv.de/dms/ilmenau/abs/515906050foers.txt.
Texto completoSchwarz, Stefan U. [Verfasser] y Oliver [Akademischer Betreuer] Ambacher. "Biofunktionalisierung und -sensorik mit AlGaN/GaN-Feldeffekttransistoren". Freiburg : Universität, 2013. http://d-nb.info/1123478864/34.
Texto completoBeutel, Tobias [Verfasser]. "Mikrotechnische Sensorik für aktive Hochauftriebssysteme / Tobias Beutel". Aachen : Shaker, 2013. http://d-nb.info/1052407900/34.
Texto completoRuprecht, Aiko. "Konfokale Sensorik zur Hochgeschwindigkeits-Topografiemessung technischer Objekte /". Stuttgart : ITO, 2008. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016794629&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Texto completoSchuler, Karin. "Intelligente Antennensysteme für Kraftfahrzeug-Nahbereichs-Radar-Sensorik". [S.l. : s.n.], 2007. http://digbib.ubka.uni-karlsruhe.de/volltexte/1000007776.
Texto completoBergmann, Annika [Verfasser]. "Die Nasen-Spray-Sensorik-Skala / Annika Bergmann". Köln : Deutsche Zentralbibliothek für Medizin, 2017. http://d-nb.info/1126978515/34.
Texto completoDel, Bene Nicola. "Tracciamento del movimento tramite sensori inerziali". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14238/.
Texto completoMuccioli, Alberto. "Tecniche di posizionamento mediante sensori inerziali". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15574/.
Texto completoDelliaux, Stéphane. "Oxygénation musculaire et contrôle sensori-moteur". Aix-Marseille 2, 2007. http://www.theses.fr/2007AIX20700.
Texto completoLONGATO, ALESSANDRO. "Materiali nanostrutturati per sensori di gas". Doctoral thesis, Università degli studi di Padova, 2022. https://hdl.handle.net/11577/3460976.
Texto completoMy research work during the PhD was devoted to the development of optical gas sensors for two important constituents of natural gas: odorants and hydrogen. Odorants are added in natural gas because it is naturally colorless, tasteless and odorless. Therefore, before it is distributed to end-users, small amounts of thiols are added to assist in leak detection. The two most used odorants in Italian pipelines are TBM and THT. It is very important to measure these odorants: a too low concentration does not allow a person to detect if there is a leak, a too high concentration might alarm in vain. Currently, odorants in natural gas are measured with gas chromatography (GC). GC, however, has several flaws, such as high cost, routine maintenance and it requires a skilled technician to operate. Since both THT and TBM have a characteristic UV absorption spectrum, during this PhD project, a working prototype called MUDO (Mid-UV Detector for Odorants) that relies on UV absorption has been fabricated. The prototype comprises a deuterium lamp as a source of UV light, two optical fibers, two collimators, a gas flow cell and a UV Spectrometer. Moreover, two programs were written in python to operate the hardware, to collect spectra and to compute the concentrations. With MUDO, two on-site tests were made, one in Vicenza, where the gas network is odorized with THT, and one in Milan, where the gas network is odorized with TBM. These tests were performed in parallel to a GC, used as a reference. The results acknowledged MUDO as a valid method to measure odorant concentration in natural gas, as the difference between the values measured by MUDO and by GC managed to always stay between ±10%. Natural gas is a considerable portion of the world’s total energy supply. However, in the last few years, particular attention has been given to the transition to renewable energy, including the use of hydrogen. Indeed, to reduce the effects of climate change, the role of hydrogen will be very important. An immediate use for hydrogen is the decarbonization of heat: as it is a gaseous molecule at atmospheric conditions, it can be used as a direct replacement for natural gas within the gas grid. In various countries, trials have started to implement hydrogen in natural gas pipelines up to a percentage of 20% mol. This enables a lower carbon emission, without customers requiring disruptive and expensive changes in their homes. With this new path outlined, a new need emerges: the need to correctly determine the concentration of hydrogen in the natural gas pipeline. During this PhD, a gasochromic sensor for hydrogen based on noble metal (Au, Pt) nanoparticles covered Tungsten Oxide thin film was developed. Sensing performances are strongly influenced by the crystal structure and the catalyst used, with Pt coated crystalline tungsten oxide resulting as best. Nanoparticle’s dimensions, especially in the case of gold, seem to play a role in the mechanism, with smaller NPs displaying better H2 intake. Computational insights based on Density Functional Theory calculations suggest that this could be related to the processes occurring at the nanoparticle-WO3 interface. While platinum allows both heterolytic (i.e. at the interface) and homolytic (i.e. only on the metal) hydrogen dissociative adsorption, gold can catalyze only heterolytic absorption. These evidences, in combination with an analysis of the charges distribution, explain both the inferior sensing performances of Au compared to Pt and the strong dependance of sensing performances on nanoparticle size, which dictates the extension nanoparticle-WO3 interface. Finally, Pt NPs coated crystalline tungsten oxide thin films displayed excellent hydrogen sensing performances in methane. With various tests, the sensor proved to have excellent accuracy, repeatability and long term stability, with performances relatively independent from gas flow or atmosphere.
Loprese, Alessia. "Parametri temporali del cammino in acqua tramite sensori inerziali impermeabili: confronto fra algoritmi e posizioni dei sensori". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13289/.
Texto completoWurzinger, Olaf [Verfasser]. "CO-Sensorik in H2-reichen Gasen / Olaf Wurzinger". Aachen : Shaker, 2004. http://d-nb.info/1172615217/34.
Texto completoNaghi, Nour. "Caratterizzazione e testing di Sensori Hall Commerciali". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/9953/.
Texto completoMarini, Enrico. "Analisi biomeccanica del nuoto tramite sensori inerziali". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Buscar texto completoVergilino-Perez, Dorine. "Les transformations sensori-motrices pendant la lecture". Paris 5, 2001. http://www.theses.fr/2001PA05H038.
Texto completoThe goal of this thesis is to specify when and in which coordinate system the sensorimotor transformations involved in the planning of saccades in reading are carried out. The first series of experiments uses a visually and memory-guided saccades paradigm. The results demonstrate that readers hold an internal motor plan in at least two different reference frames that are specific to the action to be performed : to aim for a new target word or to read it over with a second fixation. When a word is selected as a target for the next saccade, the spatial location of the second target is encoded in head-centered coordinates before the first saccade. Then, the second saccade is updated with respect to the current eye position after the first saccade in order to aim a fonctional target location in the second word that is the word's center. (. . . )
PAGURUT, ROBERTO. "GESTIONE DEI SENSORI DI UN MMS TERRESTRE". Doctoral thesis, Università degli studi di Trieste, 2005. http://thesis2.sba.units.it/store/handle/item/13067.
Texto completoI laboratori cartografici mobili (noti come Mobile Mapping Systems, MMS) terrestri sono sistemi di concezione relativamente recente, con i primi veicoli completi operanti all'inizio degli anni 90. L'Università degli Studi di Trieste è stata capofila in un progetto (COFIN 2001) coinvolgente diversi atenei italiani per la realizzazione operativa di un veicolo MMS ad alta produttività con elevata precisione di posizionamento. Il veicolo finale monta strumentazione di qualità, il pezzo più importante essendo un sistema integrato GPS/INS di elevata precisione, ed è in grado di raccogliere dati di posizione contemporaneamente a dati di tipo geografico; il sistema è "aperto", nel senso che nuovi sensori possono venire integrati in caso di necessità o per sperimentazioni. Il lavoro di tesi è incentrato sul veicolo, o, meglio, sui vari sensori presenti sul veicolo e sull'elaborazione dei dati forniti da essi. Il contributo originale si può riassumere schematicamente nei seguenti punti: Allestimento di parte della strumentazione e gestione dell'alimentazione Sincronizzatore degli eventi Analisi ed elaborazione dei fotogrammi Interpretazione, analisi ed elaborazione dei dati del laser scanner La suddivisione della tesi rispecchia i punti appena citati: il primo capitolo si occupa dell'evoluzione del veicolo GIGI, del allestimento strumentale e dei componenti hardware aggiuntivi che sono stati approntati; il secondo capitolo si occupa del problema traiettografico, accennando alle diverse tecniche impiegate dalla strumentazione per ottenere la migliore traiettoria possibile, riportando i risultati di alcuni esperimenti effettuati con l'INS, e mostrando, con un buon numero di esempi, la qualità del risultato finale. Il terzo capitolo infine, incentrato sui sensori dedicati al rilievo "geografico", si può dividere idealmente in due sezioni: la prima si occupa delle telecamere e dei dati raccolti con esse; la seconda parte verte tutta sul laser scanner. Nella sezione dedicata alle telecamere viene studiato un problema legato al tempo d'esposizione del fotogramma, e viene presentato un metodo che consente, entro ampi margini, di recuperare informazione dai fotogrammi sottoesposti. Inoltre viene proposto un algoritmo per la ricerca automatica delle fessurazioni sulla pavimentazione stradale. La sezione relativa al laser scanner si occupa prima dell'interpretazione del dato del sensore, che, per poter essere utilizzato nella maniera che serviva, ha richiesto la scrittura di un apposito programma (in Visual Basic). Seguono un certo numero di esempi di scansioni, con le quali viene mostrato quale tipo d'informazione può essere ottenuta implementando questo nuovo sensore sul veicolo, e sulle quali vengono effettuate delle misure, che vengono confrontate con i valori veri misurati in loco. In chiusura è presentato un algoritmo mediante il quale è possibile, sotto opportune ipotesi, determinare in maniera automatica, data una serie di scansioni, le pendenze trasversali della strada e la distanza fra gli elementi che la delimitano ai bordi.
XVII Ciclo
1964
Versione digitalizzata della tesi di dottorato cartacea.
Battistini, Gionata <1977>. "Sensori chimici basati su molecole e nanoparticelle". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1037/1/Tesi_Battistini_Gionata.pdf.
Texto completoBattistini, Gionata <1977>. "Sensori chimici basati su molecole e nanoparticelle". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amsdottorato.unibo.it/1037/.
Texto completoSchuler, Karin [Verfasser]. "Intelligente Antennensysteme für Kraftfahrzeug-Nahbereichs-Radar-Sensorik / Karin Schuler". Karlsruhe : IHE, 2007. http://d-nb.info/998336378/34.
Texto completoMüller, Hagen [Verfasser]. "Sensorik zur Messung der Ölalterung mittels Lumineszenz / Hagen Müller". Aachen : Shaker, 2003. http://d-nb.info/1174513691/34.
Texto completoTeunissen, Jörg [Verfasser]. "Faseroptische Sensorik zum Temperatur-Monitoring von Leistungstransformatoren / Jörg Teunissen". Aachen : Shaker, 2003. http://d-nb.info/1174513535/34.
Texto completoFörster, Christian [Verfasser]. "Mikro- und nanoelektromechanische Resonatoren für die Sensorik / Christian Förster". Aachen : Shaker, 2006. http://d-nb.info/1170535763/34.
Texto completoBuder, Ulrich. "2D-Sensorik für das Monitoring statischer und dynamischer Wandschubspannungsfelder". Düsseldorf VDI-Verl, 2009. http://d-nb.info/994857705/04.
Texto completoGraf, Moritz Anton [Verfasser]. "Faseroptische Sensorik zur Schadensdetektion in Kabelgeflechten / Moritz Anton Graf". Düren : Shaker, 2020. http://d-nb.info/1208599283/34.
Texto completoCasali, Marco. "Ottimizzazione del funzionamento di un sensore industriale a triangolazione ottica basato su trasduttori lineari d'immagine". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/17614/.
Texto completoWestling, Magnus. "Att äta eller inte äta? : Mikrobiologisk och sensorisk analys av opastöriserade franska dessertostar". Thesis, Örebro universitet, Restaurang- och hotellhögskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-29586.
Texto completoAchilli, Andrea. "Transistor elettrochimici tessili come sensori per elettronica indossabile". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8897/.
Texto completoAmadei, Simone. "Sensori resistivi per un microsistema di monitoraggio ambientale". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2013. http://amslaurea.unibo.it/6387/.
Texto completoBelletti, Francesco. "Soluzioni wireless low power per nodi sensori miniaturizzati". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15659/.
Texto completoGiammarruto, Alessio. "Smart structures: sperimentazione mediante attuatori e sensori innovativi". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2008. http://amslaurea.unibo.it/93/.
Texto completoSPERANDIO, PAOLO. "Algoritmi di localizzazione per reti di sensori wireless". Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/773.
Texto completoGuadagnini, Lorella <1982>. "Elettrodi modificati per lo sviluppo di sensori elettrochimici". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2622/1/Guadagnini_Lorella_tesi.pdf.
Texto completoGuadagnini, Lorella <1982>. "Elettrodi modificati per lo sviluppo di sensori elettrochimici". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2010. http://amsdottorato.unibo.it/2622/.
Texto completoMARCHETTI, SIMONE. "Sensori optoelettronici basati su polimeri a stampo molecolare". Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1251275.
Texto completoThe research was focused on the development of marker-free optical sensors based on plastic optical fibers (POF). These are particularly suitable for sensing application because of their exceptional flexibility, large numerical aperture, and easy manipulation. Also, they are able to withstand smaller bend radii than glass fibers. Therefore, POFs are suitable for the realization of low-cost and miniaturized optical sensors both robust and highly sensitive for application with a remote control. Two approaches have been exploited the first in which the optical platform was directly developed on plastic optical fibers (POF) (intrinsic sensors) and the second that employ different waveguides made for example of PMMA or PET (extrinsic sensors). The two approaches show distinct characteristics of easy preparation and have been investigated to obtain a better reproducibility. In both sensors, different optical phenomena have been exploited, in particular, surface plasmon resonance (SPR) and the evanescent wave coupling (EWC). All the sensors employ synthetic biomimetic receptors, i.e. molecularly imprinted polymers (MIPs) for the detection of analytes in complex aqueous or organic matrices. The most commonly used bio-receptors, despite their high selectivity and sensitivity, suffer from great disadvantages as not being available for all the substrate, being limited to the biological condition of analysis and requiring an expensive and time-consuming development procedure. Instead, MIPs are more resistant, even in harsh conditions of analysis, while maintaining the high affinity and selectivity of the biological receptors, so making these synthetic receptors really promising for sensing purposes. Some specific MIPs have been developed, based on non-covalent interactions template-functional monomers, and with the most common composition as far as the functional monomer and the cross-linker are concerned. In some cases, the MIP composition was optimized by computational methods considering different functional monomers and cross-linkers as well as possible interfering interactions. The MIPs characteristics, as the affinity constant, the capacity of uptake and selectivity have been evaluated by batch procedure and the flow procedure. Porous MIP particles and MIP beads have been considered and characterized by batch equilibration. In particular MIPs for sensing the following molecules have been developed and characterized: 2-FAL (2-furhaldehide) and dibenzyldisulfide (DBDS) because of their rising importance as useful markers of health status of the middle tension transformers in the large distribution energy. 2-FAL was considered in aqueous matrices too, in view of its relevance in food quality control. The optical sensors developed have been characterized by determining the adsorption isotherms on the polymeric layer, based on the sensor response. The sensors based on SPR appear to be really promising due to the optimal sensitivity, low cost and possibility of miniaturization by employing POFs. Moreover, a high selectivity and affinity constant (Kaff), a low LOD and the possibility of the re-use are provided by the successful implementation of MIPs as receptors. Similar optimal results have been obtained by the evanescent wave coupling (EWC) moreover this platform presents the advantages of avoiding the use of Au layer, so could be superior to the SPR ones for the better reproducibility. Also, new kinds of molecularly imprinted materials have been considered in order to improve the biocompatibility of the sensing devices. In particular silk fibroin has been examined for its good optical and mechanical characteristics. Moreover, it is a biomaterial already approved for biomedical applications. Preliminary results on the imprinting of fibroin with glucose have been promising, with an imprinting factor higher than one. Moreover, the imprinted material can easily obtain a thin layer, which is particularly suitable for sensor development.
MARCHETTI, SIMONE. "Sensori optoelettronici basati su polimeri a stampo molecolare". Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1251313.
Texto completoThe research was focused on the development of marker-free optical sensors based on plastic optical fibers (POF). These are particularly suitable for sensing application because of their exceptional flexibility, large numerical aperture, and easy manipulation. Also, they are able to withstand smaller bend radii than glass fibers. Therefore, POFs are suitable for the realization of low-cost and miniaturized optical sensors both robust and highly sensitive for application with a remote control. Two approaches have been exploited the first in which the optical platform was directly developed on plastic optical fibers (POF) (intrinsic sensors) and the second that employ different waveguides made for example of PMMA or PET (extrinsic sensors). The two approaches show distinct characteristics of easy preparation and have been investigated to obtain a better reproducibility. In both sensors, different optical phenomena have been exploited, in particular, surface plasmon resonance (SPR) and the evanescent wave coupling (EWC). All the sensors employ synthetic biomimetic receptors, i.e. molecularly imprinted polymers (MIPs) for the detection of analytes in complex aqueous or organic matrices. The most commonly used bio-receptors, despite their high selectivity and sensitivity, suffer from great disadvantages as not being available for all the substrate, being limited to the biological condition of analysis and requiring an expensive and time-consuming development procedure. Instead, MIPs are more resistant, even in harsh conditions of analysis, while maintaining the high affinity and selectivity of the biological receptors, so making these synthetic receptors really promising for sensing purposes. Some specific MIPs have been developed, based on non-covalent interactions template-functional monomers, and with the most common composition as far as the functional monomer and the cross-linker are concerned. In some cases, the MIP composition was optimized by computational methods considering different functional monomers and cross-linkers as well as possible interfering interactions. The MIPs characteristics, as the affinity constant, the capacity of uptake and selectivity have been evaluated by batch procedure and the flow procedure. Porous MIP particles and MIP beads have been considered and characterized by batch equilibration. In particular MIPs for sensing the following molecules have been developed and characterized: 2-FAL (2-furhaldehide) and dibenzyldisulfide (DBDS) because of their rising importance as useful markers of health status of the middle tension transformers in the large distribution energy. 2-FAL was considered in aqueous matrices too, in view of its relevance in food quality control. The optical sensors developed have been characterized by determining the adsorption isotherms on the polymeric layer, based on the sensor response. The sensors based on SPR appear to be really promising due to the optimal sensitivity, low cost and possibility of miniaturization by employing POFs. Moreover, a high selectivity and affinity constant (Kaff), a low LOD and the possibility of the re-use are provided by the successful implementation of MIPs as receptors. Similar optimal results have been obtained by the evanescent wave coupling (EWC) moreover this platform presents the advantages of avoiding the use of Au layer, so could be superior to the SPR ones for the better reproducibility. Also, new kinds of molecularly imprinted materials have been considered in order to improve the biocompatibility of the sensing devices. In particular silk fibroin has been examined for its good optical and mechanical characteristics. Moreover, it is a biomaterial already approved for biomedical applications. Preliminary results on the imprinting of fibroin with glucose have been promising, with an imprinting factor higher than one. Moreover, the imprinted material can easily obtain a thin layer, which is particularly suitable for sensor development.