Literatura académica sobre el tema "Ségrégation de l'ADN mitochondrial"
Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros
Índice
Consulte las listas temáticas de artículos, libros, tesis, actas de conferencias y otras fuentes académicas sobre el tema "Ségrégation de l'ADN mitochondrial".
Junto a cada fuente en la lista de referencias hay un botón "Agregar a la bibliografía". Pulsa este botón, y generaremos automáticamente la referencia bibliográfica para la obra elegida en el estilo de cita que necesites: APA, MLA, Harvard, Vancouver, Chicago, etc.
También puede descargar el texto completo de la publicación académica en formato pdf y leer en línea su resumen siempre que esté disponible en los metadatos.
Artículos de revistas sobre el tema "Ségrégation de l'ADN mitochondrial"
Matagne, René. "L'ADN mitochondrial : les paradoxes d'une génétique non mendélienne". Bulletin de la Classe des sciences 16, n.º 1 (2005): 53–60. http://dx.doi.org/10.3406/barb.2005.28447.
Texto completoRode, A., C. Hartmann, M. Dron, E. Picard y F. Quetier. "Stabilité de l'ADN chloroplastique et de l'ADN mitochondrial isolés de lignées deTriticum aestivumobtenues par androgenésein vitro". Bulletin de la Société Botanique de France. Actualités Botaniques 133, n.º 4 (enero de 1986): 74. http://dx.doi.org/10.1080/01811789.1986.10826804.
Texto completoDreyfus, JC. "Un locus autosomique prédisposant aux délétions de l'ADN mitochondrial". médecine/sciences 11, n.º 5 (1995): 785. http://dx.doi.org/10.4267/10608/2284.
Texto completoExcoffier, Laurent y David Roessli. "Origine et évolution de l'ADN mitochondrial humain : le paradigme perdu". Bulletins et Mémoires de la Société d'anthropologie de Paris 2, n.º 1 (1990): 25–41. http://dx.doi.org/10.3406/bmsap.1990.1713.
Texto completoQuintana-Murci, L., R. Veitia, S. Santachiara-Benerecetti, K. McElreavey, M. Fellous y T. Bourgeron. "L'ADN mitochondrial, le chromosome Y et l'histoire des populations humaines." médecine/sciences 15, n.º 8-9 (1999): 974. http://dx.doi.org/10.4267/10608/1467.
Texto completoDreyfus, JC. "Une mutation de l'ADN mitochondrial altère la régulation de sa transcription". médecine/sciences 7, n.º 7 (1991): 744. http://dx.doi.org/10.4267/10608/4449.
Texto completoDubourdieu, Denis, Aline Sokol, Joseph Zucca, Patrick Thalouarn, Agnès Dattee y Michel Aigle. "Identification des souches de levures isolées de vins par l'analyse de leur ADN mitochondrial". OENO One 21, n.º 4 (31 de diciembre de 1987): 267. http://dx.doi.org/10.20870/oeno-one.1987.21.4.1286.
Texto completoQuintana-Murci, L. "Les révélations de l'ADN mitochondrial : une deuxième sortie d'Afrique d'Homo sapiens sapiens." médecine/sciences 16, n.º 3 (2000): 450. http://dx.doi.org/10.4267/10608/1672.
Texto completoMonnot, Sophie, Nadine Gigarel, Arnold Munnich, Marlène Rio, Nelly Frydman, Laetitia Hesters, Jean-Paul Bonnefont y Julie Steffann. "Faisabilité et incertitude du diagnostic préimplantatoire appliqué aux mutations de l'ADN mitochondrial". Revue Francophone des Laboratoires 2018, n.º 501 (abril de 2018): 58–64. http://dx.doi.org/10.1016/s1773-035x(18)30121-7.
Texto completoBelcour, L., M. Dequart-Chablat y M. Picard. "Délétion site-spécifique de l'ADN mitochondrial sous le contrôle de deux gènes nucléaires". médecine/sciences 7, n.º 6 (1991): 628. http://dx.doi.org/10.4267/10608/4423.
Texto completoTesis sobre el tema "Ségrégation de l'ADN mitochondrial"
Steffann, Julie. "Etude de la ségrégation de l'ADN mitochondrial au cours du développement embryofoetal humain". Paris 5, 2006. http://www.theses.fr/2006PA05N17S.
Texto completoInherited disorders resulting from mutations of mitochondrial DNA (mtDNA) are serious diseases with a high recurrence risk due to their maternal mode of inheritance. Variability in clinical severity and various multi-tissual involvement result in a large extent from the coexistence of wild-type and mutant mtDNA molecules in various proportions in different tissues (heteroplasmy). Uncertainties regarding the potential variation of heteroplasmy load during human embryofetal development had hampered the development of prenatal (PND) and preimplantation (PGD) diagnostic procedures. Moreover, the restriction of the mtDNA molecule number, through a putative bottleneck at the time of
Wallet, Clementine. "L'hélicase RECG1, un facteur-clé dans le maintien et la ségrégation de l'ADN mitochondrial d'Arabidopsis thaliana". Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ016/document.
Texto completoThe mitochondrial DNA (mtDNA) of flowering plants is characterized by the recombination activities that modulate its structure. These activities are required for the mtDNA maintenance, and drive its rapid structural evolution. The factors that control recombination are therefore essential for plant mtDNA stability. During my PhD, I identified and characterized two DNA helicases that are present in the organelles of Arabidopsisthaliana. One is the homologue of a bacterial helicase involved in transcription-coupled repair. Its role in the plant organelles is still not determined. The other one, the RECG1 helicase, has roles in recombination dependent repair, the surveillance of ectopic recombination involving short repeated sequences, and also the segregation of the mtDNA. We have found that in the absence of RECG1 there is loss of recombination control resulting in the occurrence of alternative versions of the mtDNA generated by recombination. The analysis oftheir segregation, induced by RECG1, allowed us to build a model to how new stable mtDNA configurations are generated by the stoichiometric shift of mtDNA sub-genomes. This work allowed us to better understand the recombination and segregation mechanisms that modulate the Arabidopsis mtDNA
Kubilinskas, Rokas. "MitoTALENs to explore mitochondrial DNA repair and segregation". Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ014.
Texto completoFor long, the plant mitochondrial genome (mtDNA) was not amenable to manipulation, until recent advancements in genome engineering using Transcription Activator-Like Effector Nucleases (TALEN). In this work I used TALENs specifically targeted to mitochondria (mitoTALENs) to study plant mtDNA repair and segregation. MitoTALEN constructs were transformed into the background of 10 different Arabidopsis thaliana mutant lines, deficient in various factors involved in plant mitochondrial repair by homologous recombination. The resulting lines were analysed by Illumina sequencing and qPCR approaches. In wild type plants, the mtDNA double-strand-break (DSB) induced by MitoTALENs was repaired by homologous recombination, resulting in the replacement of the region containing the DSB by a distal unaffected sequence of the mtDNA, flanked by the same set of repeated sequences. In mutants deficient in repair factors, repair could shift to alternative pathways, such as Single-Strand Annealing (SSA) and Microhomology-mediated recombination (MHMR). Furthermore, in some mutants, the data revealed no evidence of DSB repair, but rather suggested that plants deficient in key repair factors could survive by reconstituting an alternative viable mitochondrial genome, from pre-existing autonomously replicating sub-genomes
Bourdon, Alice. "Ribonucléotide réductase et synthèse de l'ADN mitochondrial". Paris 5, 2009. http://www.theses.fr/2009PA05T006.
Texto completoMitochondrial DNA (mtDNA) depletions are characterized by a decreased number of mtDNA molecules and constitute a major cause of respiratory chain deficiency. This work allowed us to identify a new nuclear gene of mtDNA depletion associated with a severe encephalomyopathy leading to death in the first months of age. This gene encodes a small ribonucleotide reductase (RNR) subunit p53R2 which is a target of the transcription factor p53. RNR catalyses the reduction of the nucleotides into their corresponding desoxyribonucleotides, which is the rate limiting step for DNA synthesis. The second part of this work focuses on the role of p53R2 in mtDNA replication studying its subcellular localization and the expression of the subunits of RNR in several mouse tissues during development
Biju, Duval Christophe. "Diversité de l'ADN mitochondrial chez les lagomorphes". Paris 6, 1992. http://www.theses.fr/1992PA066046.
Texto completoNguyen, Minh Huong. "Infertilité masculine : fragmentation de l'ADN spermatique, ségrégation méiotique et facteurs génétiques". Thesis, Brest, 2015. http://www.theses.fr/2015BRES0034/document.
Texto completoInfertility affects about 15% of couples with male factor found in half of the cases. This Ph.D thesisinvestigates three causes of male infertility including chromosomal abnormality, genetic disorderand factors related to alterations in sperm DNA quality. The thesis is organized into two parts.In the first part, the chromosomal equipment and sperm DNA fragmentation in gametes of infertilemen were assessed by FISH and TUNEL. On the one hand, a high rate of aneuploid gametes andsperm DNA fragmentation were observed in four patients with gonosomal mosaicism. On the otherhand, analysis of chromosomal equipment and sperm nuclear DNA in each gamete from 13 patientswith structural chromosome abnormalities showed that unbalanced gametes have more fragmentedDNA than normal or balanced ones.In the second part, a technique for analysing the transcriptome in spermatozoa was developed onfresh and frozen semen. In fact, the combination of a discontinuous density gradient and a somaticcell lysis solution makes it possible to completely eliminate somatic cells and to recover as manysperms in the semen as possible. The XS NucleoSpin RNA kit (Macherey Nagel) was found to bemore suitable for RNA extraction than the RNA extraction kit from Qiagen. The purity of sperm RNA was verified by both RT-PCR and the Bíoanalyzer 2100. These two methods have yieldedsimilar and consistent results. The microarray analysis showed that fresh sperms do not share thesame gene expression profile than frozen ones
DEGOUL, FRANCOISE. "Mutations de l'adn mitochondrial dans differentes myopathies humaines". Clermont-Ferrand 2, 1991. http://www.theses.fr/1991CLF21276.
Texto completoRocher, Christophe. "Anomalies de l'ADN mitochondrial et métabolisme mitochondrial : Mécanismes des déplétions et des délétions". Bordeaux 2, 2001. http://www.theses.fr/2001BOR28910.
Texto completoOne of the fundamental problems of the study of mitochondrial metabolism integration in cellular metabolism is to understand how mitochondrial metabolism is controlled (regulated) ? The subject of this thesis concerns this topic and tries to answer the two following questions : 1- What are the repercussions of a mitochondrial DNA (mtDNA) amount variation at the level of the energy metabolism ? We used two models which are : (i) a lymphoblastoid cell line coming from a patient for whom a 99 % decrease of the muscle mtDNA amount was observed (depletion), but also (ii) a series of stable mtDNA depleted cell lines obtained by treatment of a control one with nucleotides analogues (AZT and ddC). The results clearly indicate that cellular mtDNA amount is one important parameter in the regulation of oxidative phosphorylations. Indeed, despite the high copy number of mtDNA, a small decrease in its content has severe implications on mitochondrial bioenergetics. Consequently, the quantity of mtDNA in the cell is a parameter to take into account for the study of mitochondrial pathologies as well as the nature or the heteroplasmlic level of a mtDNA mutation. 2- What are the molecular mechanisms involved in the generation of human mitochondrial DNA rearrangements, such as large-scale deletions ? Some mitochondrial pathologies areare due to such reorganizations of mtDNA and different mechanisms have been proposed to explain these rearrangements. The mechanism of slipped mispairing has been proposed but no molecular bases are described. The results we obtained show that the formation of a triple helix could be involved in the generation of mtDNA deletions as well as partial duplications or triplications
Quebre, Valentin. "Etude des complexes ADN-protéines impliqués dans la ségrégation de l'ADN bactérien". Thesis, Toulouse 3, 2022. http://www.theses.fr/2022TOU30072.
Texto completoBacterial chromosomes and low copy number plasmids segregation is based on an active positioning mechanism. It consists in the partition systems that ensures the proper intracellular positioning of replicons to be faithfully transmitted to the daughter cells. The partition systems involves three cis-encoded partners. A DNA binding protein (ParB), is assembled in partition complexes at centromeric sequences (parS). An NTPase, which interacts with the partition complex, drives the segregation process and allows the complexes, and thus the plasmids, to be properly positioned inside the cell. My Ph.D project focused first on the better understanding of the partition complex assembly of the widespread type I system of the F plasmid and pESBL. Then, to decipher the global mechanism of the partition process of the recently discovered atypical system on R388, which does not involve any plasmid encoded NTPase to ensure its intracellular positioning. Thus, my project is divided in three parts, aiming to (i) understand by an mutational approach, the initiation mechanism for the self-assembly of the majority of F plasmid ParB in a dynamic high molecular weight complex around parS, (ii) identify the pESBL partition system partners, in vitro characterize the ParB/parS interaction profile and in silico determine the group to which it belongs, (iii) identify the roles of the different domains of the R388 DNA binding protein StbA in its activities and characterize the StbA interaction modalities on its centromere by high throughput sequencing and biochemical approaches, to understand the partition complex architecture. This study allows us to improve our knowledge on the Type I partition system and to shed light on the DNA/protein interaction specificities of an atypical system, carried by broad-host-range plasmids, opening the way to a better understanding of DNA segregation mechanism
Legros, Frédéric. "Étude de la dynamique du compartiment mitochondrial et des mutations hétéroplasmiques de l'ADN mitochondrial". Paris 7, 2002. http://www.theses.fr/2002PA077109.
Texto completoLibros sobre el tema "Ségrégation de l'ADN mitochondrial"
Alain, Branchaud, ed. Identification des larves et des oeufs des suceurs, Moxostama, par analyse de l'ADN mitochondrial. Québec: Gouvernement du Québec, Ministère de l'environnement et de la faune, Direction de la faune et des habitats, 1996.
Buscar texto completoBernatchez, Louis. Comparaison de l'ADN mitochondrial des éperlans arc-en-ciel (Osmerus mordax) frayant dans les régions de Beaumont, de Rivière-Ouelle et de la Baie des Chaleurs en 1990. Québec: Ministère du loisir, de la chasse et de la pêche, 1992.
Buscar texto completo