Tesis sobre el tema "Science biological sciences biophysics"
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Nichols, Alexander J. "Optical Molecular Sensing in Complex Biological Environments". Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226087.
Texto completoRamsey, Nicole B. "Bilayer perturbation is a distinct parameter for regulating the experimental use of biological probes and the development of antimalarials". Thesis, Weill Medical College of Cornell University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3580196.
Texto completoThe controlled production and degradation of cAMP allows for control of many different signaling pathways. cAMP is produced by genetically distinct transmembrane (tmAC) and soluble (sAC) adenylyl cyclases; cAMP is catabolized by phosphodiesterases (PDEs). The relative contributions of sAC and tmAC to cAMP production, and of the PDEs to cAMP catabolism, usually are explored using pharmacological interventions. Because the compounds used to manipulate intracellular cAMP levels must cross cell membranes, they need to partition into lipid bilayers, which raises the question whether they could alter cell function by mechanisms that are unrelated to the changes in cAMP turnover. Indeed, many of these compounds are known to alter the function of other membrane proteins at concentrations that overlap with those used to target cAMP metabolism. Moreover, the concentration range(s) used to obtain the same effect vary widely among experiments, suggesting that these compounds elicit off-target effects that do not involve conventional cAMP signaling pathways. I therefore explored the lipid bilayerperturbing effects of 17 commonly employed modifiers of sAC, tmAC and PDE activity using a GBFA. Twelve compounds perturbed the bilayer at commonly used concentrations. Thus, in addition to their effects on cAMP metabolism, these molecules may alter cell function by being promiscuous modifiers of membrane protein function, meaning they should be used with care. Effects that occur only at concentrations that are three or more times higher than those for half-maximal effect (on the intended target) should be interpreted with caution.
In addition to being important for the interpretation of experiments that explore biological function with small-molecule probes, bilayer perturbation is also an important parameter for drug discovery. In this thesis, I focused on how to improve the development of new malaria therapies, which is necessary due to the perpetual development of resistance to current therapies. The Medicines for Malaria Venture developed the Malaria Box to facilitate the drug development process (and reduce the cost) by providing pharmaceutical company-vetted drug candidates to academicians. To explore whether testing for membrane effects might reduce the expenses required for drug development, I tested the 80 potent compounds from the Malaria Box for bilayer-mediated effects on membrane protein conformational changes (as a measure of literature. However, some significant differences should be further examined in other international teaching environments.
Lee, Peilun. "BIOLOGICAL FUNCTIONS OF THE NOVEL LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR, LPA4/p2y9/GPR23". VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1676.
Texto completoBurnette-Vick, Bonnie A. "Characterization of Two Temperature-sensitive Mutants of Escherichia Coli Exhibiting an Altered L22 Ribosomal Protein". Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2645.
Texto completoPaccione, Rachel J. "Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells". VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1084.
Texto completoJain, Dharamdeep. "Humidity Driven Performance of Biological Adhesives". University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1510053266807976.
Texto completoRodriguez, Idaykis. "An Ethnographic Study: Becoming a Physics Expert in a Biophysics Research Group". FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/938.
Texto completoChen, Yuejin. "Characterization of the Vasoactivity of Tachykinins in Isolated Rat Kidney: Functional Studies and in Vitro Receptor Autoradiography". Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etd/2892.
Texto completoRatnasinghe, Duminda D. "Unusual Structure of a Human Middle Repetitive DNA". Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2767.
Texto completoLu, Zhixin. "Investigations on Cancer Cell Biological Effects of CDK8 Inhibitor Q-12". Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3554.
Texto completoConde, Pueyo Núria 1983. "Biological computation in yeast". Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/320193.
Texto completoEn el camp de la biologia sintètica els esforços s'han dirigit a construir dispositius computacionals artificials connectant les unitats lògiques bàsiques (portes lògiques). Aquests esforços, estan limitats per l'anomenat “wiring problem”: cada connexió entre les unitats lògiques s'ha d'implementar amb una molècula diferent. En aquesta tesi es mostra una manera no-estàndard d'implementar funcions lògiques que redueix el nombre de cables necessaris gràcies a un disseny multicel·lular amb una distribució de la sortida en diferents cèl·lules. Es presenta una implementació pràctica utilitzant una llibreria de cèl·lules de llevat enginyeritzades, on cada constructe genètic defineix una funció lògica. Això posa de manifest el gran potencial que suposa la re-utilització dels elements genètics per construir les diferents cèl·lules. Al mateix temps, les cèl·lules es poden combinar de múltiples maneres permetent la construcció fàcil de diferents circuits sintètics complexes. En el primer article, proposem un disseny en múltiples capes. Les cèl·lules modificades genèticament poden realitzar les lògiques: IDENTITY, NOT, AND i NIMPLIES i són capaces de comunicar-se utilitzant dues connexions diferents. Com a demostració experimental, s'han implementat varies portes lògiques i circuits més complexos tals com un sumador d'un bit. En el segon article, es proposa una arquitectura general, que defineix un consorci cèl·lular, capaç d'implementar qualsevol circuit independentment de la seva complexitat. Aquest disseny es basa en cèl·lules que realitzen les lògiques IDENTITY i NOT, organitzades en dues capes. L’aspecte clau d’aquesta arquitectura és l’aïllament espaial. Aquest disseny permet implementar funcions lògiques molt complexes tals com multiplexor—4a1 utilitzant una sola molècula cable.
Unis, Melod. "Peroxide reactions of environmental relevance in aqueous solution". Thesis, Northumbria University, 2010. http://nrl.northumbria.ac.uk/2284/.
Texto completoSeashols, Sarah. "Variation and Modulation of microRNAs in Prostate Cancer and Biological Fluids". VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3258.
Texto completoZhang, Meng. "Proteomic analysis of streptococcus pyogenes". Thesis, Northumbria University, 2007. http://nrl.northumbria.ac.uk/842/.
Texto completoJing, Stanley Mofor. "Synthesis of Resveratrol Esters and Aliphatic Acids". Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1382.
Texto completoThinnes, Cyrille Christophe. "Chemical and biological studies on human oxygenases". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:455f2e65-f294-461b-b44f-cd53796b14a0.
Texto completoAggrawal, Manali. "Study of DNA damage on DNA G-quadruplexes and biophysical evaluation of the effects of modified bases (lesions) on their conformation and stability". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/134.
Texto completoFu, Josephine K. Y. "Functional characterization of the teleost multiple tissue (tmt) opsin family and their role in light detection". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:39bc18bb-16cb-4549-94cd-5f872daafe7e.
Texto completoHuisman, Maximiliaan. "Vision Beyond Optics: Standardization, Evaluation and Innovation for Fluorescence Microscopy in Life Sciences". eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1017.
Texto completoChavan, Archana G. "Exploring the molecular architecture of proteins| Method developments in structure prediction and design". Thesis, University of the Pacific, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3609082.
Texto completoProteins are molecular machines of life in the truest sense. Being the expressors of genotype, proteins have been a focus in structural biology. Since the first characterization and structure determination of protein molecule more than half a century ago1, our understanding of protein structure is improving only incrementally. While computational analysis and experimental techniques have helped scientist view the structural features of proteins, our concepts about protein folding remain at the level of simple hydrophobic interactions packing side-chain at the core of the protein. Furthermore, because the rate of genome sequencing is far more rapid than protein structure characterization, much more needs to be achieved in the field of structural biology. As a step in this direction, my dissertation research uses computational analysis and experimental techniques to elucidate the fine structural features of the tertiary packing in proteins. With these set of studies, the knowledge of the field of structural biology extends to the fine details of higher order protein structure.
Hekman, Ryan Matthew. "Production of Synthetic Spider Silk". Scholarly Commons, 2018. https://scholarlycommons.pacific.edu/uop_etds/3534.
Texto completoScarlett, Michael A. "Can a comprehensive transition plan to barefoot running be the solution to the injury epidemic in American endurance runners?" Scholarship @ Claremont, 2018. http://scholarship.claremont.edu/cmc_theses/1830.
Texto completoGenevskiy, Vladislav. "Biophysical differences between COPD, CF and healthy airways mucus". Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24779.
Texto completoJonnalagadda, Sneha R. "Molecular Modulation of a-Subunit VISIT-DG Sequence Residue Asp-350 in the Catalytic sites of Escherichia coli ATP Synthase". Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1296.
Texto completoAgostini, Matteo. "Surface-acoustic-wave based biosensors and microfluidic devices for Life-science applications". Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85916.
Texto completoMueller, Christian. "Lack of CFTR in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyper-Inflammatory Adaptive Immune Responses: A Master's Thesis". eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/595.
Texto completoBurrows, Andrea C. "A social study of women in contemporary biological sciences". Diss., This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-07282008-135540/.
Texto completoWala, Zingfa Jantur. "Birds and people: studies based on citizen science and census data of Greater Gauteng, South Africa". Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29541.
Texto completoGrauby-Heywang, Christine. "Etude à l'interface air-eau de mélanges lipidiques susceptibles de former des RAFTS membranaires". Habilitation à diriger des recherches, Université Sciences et Technologies - Bordeaux I, 2008. http://tel.archives-ouvertes.fr/tel-00685610.
Texto completoMishra, Avdesh. "Effective Statistical Energy Function Based Protein Un/Structure Prediction". ScholarWorks@UNO, 2019. https://scholarworks.uno.edu/td/2674.
Texto completoWalker, Michael John. "Safeguarding food : advances in forensic measurement science and the regulation of allergens, additives and authenticity". Thesis, Kingston University, 2016. http://eprints.kingston.ac.uk/37907/.
Texto completoMurrel, Benjamin. "Improved models of biological sequence evolution". Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71870.
Texto completoENGLISH ABSTRACT: Computational molecular evolution is a field that attempts to characterize how genetic sequences evolve over phylogenetic trees – the branching processes that describe the patterns of genetic inheritance in living organisms. It has a long history of developing progressively more sophisticated stochastic models of evolution. Through a probabilist’s lens, this can be seen as a search for more appropriate ways to parameterize discrete state continuous time Markov chains to better encode biological reality, matching the historical processes that created empirical data sets, and creating useful tools that allow biologists to test specific hypotheses about the evolution of the organisms or the genes that interest them. This dissertation is an attempt to fill some of the gaps that persist in the literature, solving what we see as existing open problems. The overarching theme of this work is how to better model variation in the action of natural selection at multiple levels: across genes, between sites, and over time. Through four published journal articles and a fifth in preparation, we present amino acid and codon models that improve upon existing approaches, providing better descriptions of the process of natural selection and better tools to detect adaptive evolution.
AFRIKAANSE OPSOMMING: Komputasionele molekulêre evolusie is ’n navorsingsarea wat poog om die evolusie van genetiese sekwensies oor filogenetiese bome – die vertakkende prosesse wat die patrone van genetiese oorerwing in lewende organismes beskryf – te karakteriseer. Dit het ’n lang geskiedenis waartydens al hoe meer gesofistikeerde waarskynlikheidsmodelle van evolusie ontwikkel is. Deur die lens van waarskynlikheidsleer kan hierdie proses gesien word as ’n soektog na meer gepasde metodes om diskrete-toestand kontinuë-tyd Markov kettings te parametriseer ten einde biologiese realiteit beter te enkodeer – op so ’n manier dat die historiese prosesse wat tot die vorming van biologiese sekwensies gelei het nageboots word, en dat nuttige metodes geskep word wat bioloë toelaat om spesifieke hipotesisse met betrekking tot die evolusie van belanghebbende organismes of gene te toets. Hierdie proefskrif is ’n poging om sommige van die gapings wat in die literatuur bestaan in te vul en bestaande oop probleme op te los. Die oorkoepelende tema is verbeterde modellering van variasie in die werking van natuurlike seleksie op verskeie vlakke: variasie van geen tot geen, variasie tussen posisies in gene en variasie oor tyd. Deur middel van vier gepubliseerde joernaalartikels en ’n vyfde artikel in voorbereiding, bied ons aminosuur- en kodon-modelle aan wat verbeter op bestaande benaderings – hierdie modelle verskaf beter beskrywings van die proses van natuurlike seleksie sowel as beter metodes om gevalle van aanpassing in evolusie te vind.
Patke, Usha. "Inquiry-based laboratory investigations and student performance on standardized tests in biological science". Thesis, Walden University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3600291.
Texto completoAchievement data from the 3rd International Mathematics and Sciences Study and Program for International Student Assessment in science have indicated that Black students from economically disadvantaged families underachieve at alarming rates in comparison to White and economically advantaged peer groups. The study site was a predominately Black, urban school district experiencing underachievement. The purpose of this correlational study was to examine the relationship between students’ use of inquiry-based laboratory investigations and their performance on the Biology End of Course Test, as well as to examine the relationship while partialling out the effects of student gender. Constructivist theory formed the theoretical foundation of the study. Students’ perceived levels of experience with inquiry-based laboratory investigations were measured using the Laboratory Program Variable Inventory (LPVI) survey. LPVI scores of 256 students were correlated with test scores and were examined by student gender. The Pearson correlation coefficient revealed a small direct correlation between students’ experience in inquiry-based laboratory investigation classes and standardized test scores on the Biology EOCT. A partial correlational analysis indicated that the correlation remained after controlling for gender. This study may prompt a change from teacher-centered to student-centered pedagogy at the local site in order to increase academic achievement for all students. The results of this study may also influence administrators and policy makers to initiate local, state, or nationwide curricular development. A change in curriculum may promote social change as students become more competent, and more able, to succeed in life beyond secondary school.
Diallo, Abdoulaye. "Inference of insertion and deletion scenarios for ancestral genome reconstruction and phylogenetic analyses: algorithms and biological applications". Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40771.
Texto completoCette thèse traite d'algorithmes pour la reconstruction de génomes ancestraux et l'analyse phylogénétique. Elle étudie particulièrement les scénarios d'insertion et délétion (indels) dans les séquences génomiques, leur utilité (1) pour l'étude des familles d'espèces, (2) pour l'évaluation des alignements multiples de séquences et la reconstruction phylogénétique, (3) et pour l'annotation de séquences génomiques fonctionnelles. Dans cette thèse, le problème de la reconstruction du scénario d'indels est étudié en utilisant le critère de maximum de vraisemblance. Ce problème peut être défini de la manière suivante: étant donné un alignement multiple de séquences orthologues et un arbre phylogénétique traduisant l'histoire évolutive de ces séquences, reconstruire le scénario d'indels le plus vraisemblable capable d'expliquer les brèches présentes dans l'alignement. Ce problème, dénommé ''Indel Maximum Likelihood Problem (IMLP)'', est une importante étape de la reconstruction de séquences ancestrales. Il est également important pour l'étude des processus évolutifs, des fonctions des gènes, de l'adaptation et de la convergence.Dans une première étape de cette thèse, nous montrons que l'IMLP peut être résolu en utilisant un nouveau type de données combinant un arbre phylogénétique et un modèle de Markov caché. Les états de ce modèle de Markov caché correspondent à un scénario évolutif d'une colonne de l'alignement. Ses transitions modélisent la dépendance entre les colonnes voisines de l'alignement.Les algorithmes standard de Viterbi et de Forward-Backward ont été optimisés pour produire le scénario ancestral le plus vraisemblable et pour calculer le niveau de confiance associé aux prédictions. Dans cette thèse, Nous présentons également une heuristique qui permet d'adapter la méthode à des données de grandes tailles. En second, nous montrons l'utilité du score d'indel dans l'évaluatio
Jones, Graeme Angus. "Stereoscopic correspondence processes applied to linear features". Thesis, King's College London (University of London), 1994. http://eprints.kingston.ac.uk/7544/.
Texto completoAbbass, Jad. "Secondary structure-based template selection for fragment-assembly protein structure prediction". Thesis, Kingston University, 2018. http://eprints.kingston.ac.uk/42106/.
Texto completoGlenn, Steven W. "Alpine Biological Soil Crusts in theWashington North Cascades| a Distribution Study at Select Sites Across a Precipitation Gradient". Thesis, Prescott College, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3712344.
Texto completoOne of the least researched phenomena within the alpine regions of mountain biomes is the combination of primitive plants, algae, fungi, and lichens that are generally referred to as biological soil crusts. Sites containing well-developed biological soil crusts were examined in a variety of alpine, non-forested, vegetated landscapes in the North Cascade Mountains of Washington, USA. For each site, data were recorded for percent ground cover of biological soil crusts, slope aspect, and slope gradient of the terrain where the crust communities were located. For all of the sites, biological soil crusts were common, with a percent ground cover median of 29% and a range of 11% to 73%. The arrangement of the biological soil crusts on all sites was quite similar: all were clumped, as opposed to single, and random, as opposed to uniform. All of the soil crusts were found on soil exposed to direct sunlight. Few, if any, crusts were found in the shade of heavy forbs, or forest, or under accumulations of organic litter. When biological soil crusts were found associated with higher-order vegetation, it was with sparse graminoids, ericaceous woody shrubs, and stunted or krummholz Pinaceae trees. The biological soil crusts from this study exist on all locally undisturbed soil slope-gradients from 0% to almost 100%, and occurred on all aspects except for those in the Southwest quadrant. This study contains an extended literature review for desert and high latitude circumpolar crusts, as well as alpine biological soil crusts. Studies of biological soil crusts in subalpine and alpine environments are not common; it is hoped that this study will stimulate more research interest in these often overlooked pioneer biotic communities.
Shepard, Pamela Ann. "The Use of Part-Time Faculty in Associate Degree Nursing, Social Science, and Biological Science Programs". Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc332403/.
Texto completoSeier, Edith y Karl H. Joplin. "Introduction to STATISTICS in a Biological Context". Digital Commons @ East Tennessee State University, 2011. http://amzn.com/1463613377.
Texto completoSmith, Martha Anne. "The organizational culture of the academic department: A case study of a Department of Biological Sciences". W&M ScholarWorks, 1992. https://scholarworks.wm.edu/etd/1539618811.
Texto completoCope, James S. "Computational methods for the classification of plants". Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/28759/.
Texto completoWelikala, Roshan Alex. "Automated detection of proliferative diabetic retinopathy from retinal images". Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/30591/.
Texto completoFraz, Muhammad Moazam. "Retinal image segmentation and quantification of vessel width in non-standard retinal datasets". Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/26056/.
Texto completoEsmaielbeiki, Reyhaneh. "Structural complex prediction based on protein interface recognition". Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/28209/.
Texto completoFerreira, Filipa. "Automatic and accurate segmentation of thoratic aortic aneurysms from X-ray CT angiography". Thesis, Kingston University, 2012. http://eprints.kingston.ac.uk/26293/.
Texto completoBakas, Spyridon. "Computer-aided localisation, segmentation and quantification of focal liver lesions in contrast-enhanced ultrasound". Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/30592/.
Texto completoAlsharif, Abdulla H. "Intelligent M-Health-CBT combined technology for an enhanced smoking cessation management system using data mining techniques with a case study in Saudi Arabia". Thesis, Kingston University, 2016. http://eprints.kingston.ac.uk/37875/.
Texto completoIon, Adina Izabela. "Computer aided detection and measurement of peripheral arterial diseases from CTA images". Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/26273/.
Texto completoFattah, Zahra Ali. "Applications of bipolar electrochemistry : from materials science to biological systems". Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00917770.
Texto completoBohec, Pierre. "Étude du comportement hors-équilibre du cortex cellulaire". Phd thesis, Université Paris-Diderot - Paris VII, 2012. http://tel.archives-ouvertes.fr/tel-00870466.
Texto completo