Tesis sobre el tema "Science biological sciences biology molecular biology"
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Oikonomou, Eftychia. "Molecular biology and biochemistry of brain tumours". Thesis, Aston University, 2004. http://publications.aston.ac.uk/11021/.
Texto completoLohman, Kenton L. "Isolation and Characterization of Temperature-sensitive Protein Synthesis Mutants of Escherichia Coli by Directed Mutagenesis of the Defective Bacteriophage Lambda Fus2". Digital Commons @ East Tennessee State University, 1985. https://dc.etsu.edu/etd/2722.
Texto completoChaharmahali, Pegah M. "Calcium homeostasis in Pichia pastoris". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/179.
Texto completoPacheco, Ryan John. "Characterication of aggregate gland silk factor 1". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/186.
Texto completoChu, Wei. "Mouse Mast Cell Proteases: Induction, Molecular Cloning, and Characterization". Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2656.
Texto completoYelpaala, Yuora. "The characterization of cysteine protease 4 and superoxide dismutase 6 in Trichomonas vaginalis". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/189.
Texto completoWinkler, Wade C. "RNA elements required for T box antitermination". The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1381251178.
Texto completoBuchanan, Fritz G. "Endogenous Alkylglycerol Functions As a Mediator of Protein Kinase C Activity and Cell Proliferation". Digital Commons @ East Tennessee State University, 1997. https://dc.etsu.edu/etd/2885.
Texto completoBurnette-Vick, Bonnie A. "Characterization of Two Temperature-sensitive Mutants of Escherichia Coli Exhibiting an Altered L22 Ribosomal Protein". Digital Commons @ East Tennessee State University, 1991. https://dc.etsu.edu/etd/2645.
Texto completoChittum, Harold S. "A Molecular Basis for Erythromycin Sensitivity and Resistance in Escherichia Coli". Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2655.
Texto completoBoismenu, Richard. "A molecular approach for elucidating biological functions of alpha-fetoprotein". Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41049.
Texto completoMehrpouyan, Majid. "A Temperature-sensitive Mutant of Escherichia Coli Affected in the Alpha Subunit of RNA Polymerase". Digital Commons @ East Tennessee State University, 1990. https://dc.etsu.edu/etd/2728.
Texto completoLu, Weiqun. "Application of molecular biological techniques to the identification of cyanobacteria". Thesis, Liverpool John Moores University, 1998. http://researchonline.ljmu.ac.uk/4966/.
Texto completoKumar, Shalini. "Advanced Techniques in Microbial and Molecular Biology: Laboratory Procedures for a Graduate Level Course". Thesis, University of North Texas, 1998. https://digital.library.unt.edu/ark:/67531/metadc935668/.
Texto completoPosey, Eugenia L. "The Influence of a Human Repetitive Dna on Genome Stability". Digital Commons @ East Tennessee State University, 1998. https://dc.etsu.edu/etd/2960.
Texto completoMatala, Erik John. "Molecular and biological characterization of human immunodeficiency virus type 1 envelope gp120 associated with maternal-fetal transmission". Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/298765.
Texto completoRatnasinghe, Duminda D. "Unusual Structure of a Human Middle Repetitive DNA". Digital Commons @ East Tennessee State University, 1993. https://dc.etsu.edu/etd/2767.
Texto completoKehoe, Katelin E. "Microarray analysis of Trichomonas vaginalis strains T1 and G3: Identifying genes that may contribute to virulence and metronidazole resistance". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/182.
Texto completoChuang, Tyler Casey. "Characterization of a family of cysteine rich proteins and development of a MaSp1 derived miniature fibroin". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/180.
Texto completoAravena, Andrés. "Probabilistic and constraint based modelling to determine regulation events from heterogeneous biological data". Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00922346.
Texto completoYun, Jeongfill. "Biochemical analysis of a potential drug target in the human protozoal pathogen Trichomonas vaginalis". Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/192.
Texto completoTau, Kimberly R. "Molecular and Cellular Analysis of Chlamydia Trachomatis: Persistence and Reactivation". Digital Commons @ East Tennessee State University, 1992. https://dc.etsu.edu/etd/2804.
Texto completoAhmed, Mohammed Ismail. "Morphological, ecological and molecular examination of the seacucumber species along the Red Sea coast of Egypt and Gulf of Aqaba : with the investigation of the possibility of using DNA barcoding technique as a standard method for seacucumber ID". Thesis, University of Hull, 2009. http://hydra.hull.ac.uk/resources/hull:2413.
Texto completoLu, Daniel Kee. "The Rad51 family of proteins: Interactions, vitamin D, and implications in head and neck cancer". Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/191.
Texto completoHanson-Smith, Victor 1981. "Error and Uncertainty in Computational Phylogenetics". Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12151.
Texto completoThe evolutionary history of protein families can be difficult to study because necessary ancestral molecules are often unavailable for direct observation. As an alternative, the field of computational phylogenetics has developed statistical methods to infer the evolutionary relationships among extant molecular sequences and their ancestral sequences. Typically, the methods of computational phylogenetic inference and ancestral sequence reconstruction are combined with other non-computational techniques in a larger analysis pipeline to study the inferred forms and functions of ancient molecules. Two big problems surrounding this analysis pipeline are computational error and statistical uncertainty. In this dissertation, I use simulations and analysis of empirical systems to show that phylogenetic error can be reduced by using an alternative search heuristic. I then use similar methods to reveal the relationship between phylogenetic uncertainty and the accuracy of ancestral sequence reconstruction. Finally, I provide a case-study of a molecular machine in yeast, to demonstrate all stages of the analysis pipeline. This dissertation includes previously published co-authored material.
Committee in charge: John Conery, Chair; Daniel Lowd, Member; Sara Douglas, Member; Joseph W. Thornton, Outside Member
Kilaru, Aruna, Pamela Tamura, Giorgis Isaac, Ruth Welti, Barney J. Venables, Edith Seier y Kent D. Chapman. "Lipidomic Analysis of N-Acylphosphatidylethanolamine Molecular Species in Arabidopsis Suggests Feedback Regulation by N-Acylethanolamines". Digital Commons @ East Tennessee State University, 2012. https://dc.etsu.edu/etsu-works/4755.
Texto completoGuziolowski, Carito. "Analysis of Large-Scale Biological Networks with Constraint-Based Approaches over Static Models". Phd thesis, Université Rennes 1, 2010. http://tel.archives-ouvertes.fr/tel-00541903.
Texto completoCarr, Brandon W. "Characterization of zebrafish zipper-interacting protein kinase". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/178.
Texto completoLin, Albert. "Characterizing small molecular weight proteins from Latrodectus hesperus dragline and tubuliform silks". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/184.
Texto completoDornbush, Padraick J. "Compound discovery and expression of a putative cathepsin D-like protease in Trichomonas vaginalis". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/181.
Texto completoSnowden, Kimberley Cathryn. "The molecular response of wheat roots to aluminium stress". Thesis, University of Auckland, 1994. http://hdl.handle.net/2292/1967.
Texto completoAppendix 4 restricted.
Podivinsky, Ellen. "Molecular studies on actinidin, a cysteine protease from kiwifruit". Thesis, University of Auckland, 1991. http://hdl.handle.net/2292/2001.
Texto completoMosaliganti, Kishore Rao. "Microscopy Image Analysis Algorithms for Biological Microstructure Characterization". The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1211390127.
Texto completoGill, Lyndell R. "Moraxella (Branhamella) Catarrhalis: A Molecular Epidemiology Study". Digital Commons @ East Tennessee State University, 1995. https://dc.etsu.edu/etd/2684.
Texto completoWeaver, Jun Eon. "Characterizing phenotypes of Pichia pastoris mutants that show enhanced secretion of recombinant proteins". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/188.
Texto completoSpiers, Andrew J. (Andrew Julian). "Molecular and genetic analysis of RepA from the P307 RepFIB replicon". Thesis, University of Auckland, 1992. http://hdl.handle.net/2292/2044.
Texto completoZhou, Yinhan. "Expression and functional characterization of the recombinant spider protein GW2 in yeast Pichia pastoris". Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/193.
Texto completoChoi, Eva. "Detection And Characterization of Insecticide Resistance Mechanisms in Culex Tarsalis". Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/167.
Texto completoAndersen, Ryan Otto 1979. "Dissecting Stem Cell Self-Renewal: The Roles of Mitotic Kinases in Drosophila Neuroblast Asymmetric Cell Division". Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12065.
Texto completoRegulation of stem cell self-renewal versus differentiation is critical for embryonic development and adult tissue homeostasis. Drosophila larval neuroblasts divide asymmetrically to self-renew and are a model system for studying stem cell self-renewal. Here, we identify two proteins involved in distinct steps of the cell cycle that regulate neuroblast self-renewal. We first describe three mutations showing increased brain neuroblast numbers that map to the aurora-A gene, which encodes a conserved kinase implicated in human cancer. Clonal analysis and time-lapse imaging in aurora-A mutants show single neuroblasts generate multiple neuroblasts (ectopic self-renewal). This phenotype is due to two independent neuroblast defects: abnormal atypical protein kinase C (aPKC)/Numb cortical polarity and failure to align the mitotic spindle with the cortical polarity axis. numb mutant clones have ectopic neuroblasts, and Numb overexpression partially suppresses aurora-A neuroblast overgrowth (but not spindle misalignment). We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal. We next identified an sgt1 (suppressor-of-G2-allele-of-skp1 ) mutant that had fewer neuroblasts. We found that sgt1 neuroblasts have two polarity phenotypes: failure to establish apical cortical polarity at prophase and lack of cortical Scribble localization throughout the cell cycle. Apical cortical polarity was partially restored at metaphase by a microtubule-induced cortical polarity pathway. Double mutants lacking Sgt1 and Pins (a microtubule-induced polarity pathway component) resulted in neuroblasts without detectable cortical polarity and formation of "neuroblast tumors." Mutants in hsp83 (encoding the predicted Sgt1-binding protein Hsp90), LKB1, or AMPKα all show a similar apical cortical phenotype (but no Scribble phenotype), and activated AMPKα rescued the sgt1 mutant phenotype. We propose that an Sgt1/Hsp90-LKB1-AMPK pathway acts redundantly with a microtubule-induced polarity pathway to generate neuroblast cortical polarity, and the absence of neuroblast cortical polarity can produce neuroblast tumors. This dissertation includes published and unpublished co-authored material.
Committee in charge: Dr. Bruce Bowerman, Chair; Dr. Chris Doe, Advisor; Dr. Tory Herman, Member; Dr. Judith Eisen, Member; Dr. Kenneth Prehoda, Outside Member
Mendoza, J. Alexander Hoang. "Development of a codon-optimized Latrodectus hesperus MaSp1 synthetic gene for bacterial protein expression using a seamless cloning strategy". Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/174.
Texto completoWang, Xiaodong. "Studies of CyP40 and β-tubulin in the Arnt-dependent signaling pathways". Scholarly Commons, 2006. https://scholarlycommons.pacific.edu/uop_etds/2634.
Texto completoAlbertini, Niccolo'. "New approaches to scientific visualization in virtual immersive environments for science and humanities". Doctoral thesis, Scuola Normale Superiore, 2018. http://hdl.handle.net/11384/85998.
Texto completoAndorf, Sandra. "A systems biological approach towards the molecular basis of heterosis in Arabidopsis thaliana". Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5117/.
Texto completoAls Heterosis-Effekt wird die Überlegenheit in einem oder mehreren Leistungsmerkmalen (z.B. Blattgröße von Pflanzen) von heterozygoten (mischerbigen) Nachkommen über deren unterschiedlich homozygoten (reinerbigen) Eltern bezeichnet. Dieses Phänomen ist schon seit Beginn des letzten Jahrhunderts bekannt und wird weit verbreitet in der Pflanzenzucht genutzt. Trotzdem sind die genetischen und molekularen Grundlagen von Heterosis noch weitestgehend unbekannt. Es wird angenommen, dass heterozygote Individuen mehr regulatorische Möglichkeiten aufweisen als ihre homozygoten Eltern und sie somit auf eine größere Anzahl an wechselnden Umweltbedingungen richtig reagieren können. Diese erhöhte Anpassungsfähigkeit führt zum Heterosis-Effekt. In dieser Arbeit wird ein systembiologischer Ansatz, basierend auf molekularen Netzwerkstrukturen verfolgt, um zu einem besseren Verständnis von Heterosis beizutragen. Dazu wird eine Netzwerkhypothese für Heterosis vorgestellt, die vorhersagt, dass die heterozygoten Individuen, die Heterosis zeigen, mehr regulatorische Interaktionen in ihren molekularen Netzwerken aufweisen als die homozygoten Eltern. Partielle Korrelationen wurden verwendet, um diesen Unterschied in den globalen Interaktionsstrukturen zwischen den Heterozygoten und ihren homozygoten Eltern zu untersuchen. Die Netzwerkhypothese wurde anhand von Metabolit- und Genexpressionsdaten der beiden homozygoten Arabidopsis thaliana Pflanzenlinien C24 und Col-0 und deren wechselseitigen Kreuzungen getestet. Arabidopsis thaliana Pflanzen sind bekannt dafür, dass sie einen Heterosis-Effekt im Bezug auf ihre Biomasse zeigen. Die heterozygoten Pflanzen weisen bei gleichem Alter eine höhere Biomasse auf als die homozygoten Pflanzen. Die Netzwerkhypothese für Heterosis konnte sowohl im Bezug auf mid-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Mittelwert der Eltern) als auch auf best-parent Heterosis (Unterschied in der Leistung des Heterozygoten im Vergleich zum Besseren der Eltern) für beide Kreuzungen für die Metabolit- und Genexpressionsdaten bestätigt werden. In einer Überrepräsentations-Analyse wurden die Gene, für die die größte Veränderung in der Anzahl der regulatorischen Interaktionen, an denen sie vermutlich beteiligt sind, festgestellt wurde, mit den Genen aus einer quantitativ genetischen (QTL) Analyse von Biomasse-Heterosis in Arabidopsis thaliana verglichen. Die ermittelten Gene aus beiden Studien zeigen eine größere Überschneidung als durch Zufall erwartet. Das deutet darauf hin, dass jede identifizierte QTL-Region viele Gene, die den Biomasse-Heterosis-Effekt in Arabidopsis thaliana beeinflussen, enthält. Die Gene, die in den Ergebnislisten beider Analyseverfahren überlappen, können mit größerer Zuversicht als Kandidatengene für Biomasse-Heterosis in Arabidopsis thaliana betrachtet werden als die Ergebnisse von nur einer Studie.
Li, Zhiguo. "Structure, secretion, and proteolysis study of MBP-containing heterologous proteins in Pichia pastoris". Scholarly Commons, 2010. https://scholarlycommons.pacific.edu/uop_etds/2415.
Texto completode, Moya Robert S. "Molecular Phylogenetic Analysis of Argynnis Fabricius (1807) including North American Speyeria Scudder (1872)". Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/168.
Texto completoEasley-Neal, Courtney Nichelle 1981. "Synapse Formation in the Zebrafish Spinal Cord". Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/12028.
Texto completoThis dissertation describes research to elucidate the early steps in the process of synapse formation in the zebrafish spinal cord. One question is how presynaptic proteins are trafficked and recruited to nascent synapses. Previous work has suggested two possible models of presynaptic transport, either (1) most presynaptic proteins are transported together or (2) two types of transport packets, synaptic vesicle (SV) protein transport vesicles (STVs) and Piccolo-containing active zone precursor transport vesicles (PTVs), transport the necessary components separately. We tested these models using in vivo imaging in zebrafish spinal cord and found that the recruitment of at least three distinct transport packets during presynaptic assembly of a glutamatergic synapse occurs in an ordered sequence. First, STVs are stabilized at future synaptic sites, then PTVs, followed by a third transport packet type carrying Synapsin, a cytosolic protein that can tether SVs to actin. These results identify an order to the assembly of the presynaptic terminal in vivo, suggesting that a single synaptogenic interaction may precipitate the cascade of recruitment steps. We next examined the Cadm/SynCAM family of cell adhesion molecules, a family of proteins that has been shown to be able to induce synapse formation in vitro and was thought to play a role in recruitment of presynaptic proteins. As the role of these proteins in vivo was not well understood, we chose to examine the role of the cadms in zebrafish spinal cord. We found that zebrafish possess six cadm genes, and all are expressed throughout the nervous system both during development and in the adult. We then looked at the role of one of the Cadms, Cadm2a, in vivo in the zebrafish spinal cord. We found that knockdown of cadm2a significantly decreases the ability of zebrafish embryos to respond to touch. We also found that there is a significant reduction in the number of synapses, as shown by immunohistochemistry, formed between Rohon-Beard and CoPA neurons, the first two cell types in the touch response circuit. These data suggest that Cadm2a plays an important role in synapse formation in vivo. This dissertation contains both my previously published and unpublished co-authored material.
Committee in charge: Monte Westerfield Chairperson; Philip Washbourne, Advisor; Judith Eisen, Member; Tory Herman, Member; Mike Wehr, Outside Member
Luu, Tony C. "Investigation of the role of CyP40 in the aryl hydrocarbon receptor signaling pathway". Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2383.
Texto completoUnis, Melod. "Peroxide reactions of environmental relevance in aqueous solution". Thesis, Northumbria University, 2010. http://nrl.northumbria.ac.uk/2284/.
Texto completoTran, Tiffany Doan. "Filarial infection in mosquitoes of Northern California". Scholarly Commons, 2016. https://scholarlycommons.pacific.edu/uop_etds/172.
Texto completoDevaiah, Shivakumar P. y Cecelia A. McIntosh. "Towards Understanding of Glucosyltransferase Specifi city in Citrus Paradisi". Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/350.
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