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Literatura académica sobre el tema "SAFRANALE"

Autor: Grafiati

Publicado: 10 de marzo de 2023

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Artículos de revistas sobre el tema "SAFRANALE"

A. Mahdi, Farah y Munaf H. Zalzala. "Protective Effects of Safranal Against Selenite-Induced Cataract in Rats". Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, n.º 1 (19 de junio de 2021): 196–203. http://dx.doi.org/10.31351/vol30iss1pp196-203.

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Cataract, which is the opacity inside clear ocular lens of eye, result in the scattering of visible light as it passes via the lens and consequently deterioration in optical image. The aim of the present study was to investigate whether safranal, an active constituent of Crocus sativus L. stigmas, has a protective effect on the cataract in the rat's pups. The animals were randomly divided into five groups, each of which consisted of 7 rat pups. Group I served as normal control (vehicle administration). For testing cataract induction, animals of Groups II, III, and IV were administered a single subcutaneous injection of sodium selenite on postpartum day 12. After sodium selenite intoxication, Group II served as control selenite, Groups III-IV received intraperitoneal safranal at doses of 200, and 300 mg/kg, respectively from the 11th day through the 17th day, while group V receive only safranal (300 mg/kg). On postpartum day 30, the rat pups were examined for cataract formation, and the lenses were isolated for further analysis. This study found that selenite caused significant (p < 0.05) cataract formation. Through the effects of selenite on the level of lipid peroxidation (MDA) which was upregulated. Furthermore, the antioxidant enzymes levels GSH levels and NRF2 protein were downregulated. In contrast, treatment with safranal could significantly (p < 0.05) ameliorate cataract formation and oxidative damage in the lens. Moreover, safranl administration significantly increased the protein expressions of Nrf2 and the GSH level, in addition to reducing the level both the MDA and the level soluble proteins in the lens. Taken together, safranal is a prospective anti-cataract agent that probably delays the onset and progression of cataracts induced by sodium selenite.

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Patil, P. J., S. P. Chaudhari, J. R. Patil y N. B. Bhandurge. "ANTICONVULSANT ACTIVITY OF LAMOTRIGINE POLYMERIC MICELLE AND SAFRANAL NIOSOMAL FORMULATION AGAINST STRYCHNINE-INDUCED CONVULSION". INDIAN DRUGS 53, n.º 02 (26 de febrero de 2016): 62–64. http://dx.doi.org/10.53879/id.53.02.10261.

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Lamotrigine is currently available as a tablet which is administered 2-3 times per day as divided doses of 25-600 mg. Oral liquid formulations with additional sustained release properties are always preferred for pediatric, geriatric even dysphagic patients, due to their ease of administration and patient compliance even at the time of epileptic attack. Hence, polymeric micelle formulation of lamotrigine and safranol niosomal nasal formulation were studied. Polymeric micelles containing lamotrigine were prepared by direct dissolution technique using block copolymer (Pluronic L81, Pluronic F68) in combination (1:1) ratio. Niosomes containing safranal were prepared by modified ether injection technique using non-ionic surfactants (Span 80 and Tween 20 & 80), gelucire 44/50, pluronic f-127 and cholesterol at different ratios. In this test, strychnine (4 mg/kg) was injected to the animal subcutaneously (s.c.) beneath the loose folds of neck skin. Fifteen minutes post administration of lamotrigine and safranal administration by intravenous route. Animals were observed for 10 min for occurrence and onset on various seizures. Latencies were noted in seconds. The present study is to evaluate anticonvulsant activity of lamotrigine (LTG) polymeric miceller formulation and safranal niosomal formulation on strychnine induced convulsions in mice. Vehicle failed to protect the mice from generalized clonic-tonic convulsions induced by strychnine. Lamotrigine significantly delay the onset of myoclonic, clonic and tonic extensor by all three routes i.e. nasal, intravenous and oral as compared to vehicle group. Effect of lamotrigine by nasal route is similar to the effect by intravenous route. Lamotrigine by nasal and intravenous route have shown more effect when given by oral route. Lamotrigine and safranal significantly delay the onset of myoclonic, clonic and tonic extensor by I.V. route as compared to vehicle group.

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Al-Saigh, Noor Nadhim y Shtaywy Abdalla. "Safranal Induces Vasorelaxation by Inhibiting Ca2+ Influx and Na+/Ca2+ Exchanger in Isolated Rat Aortic Rings". Molecules 27, n.º 13 (30 de junio de 2022): 4228. http://dx.doi.org/10.3390/molecules27134228.

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Introduction: Safranal, which endows saffron its unique aroma, causes vasodilatation and has a hypotensive effect in animal studies, but the mechanisms of these effects are unknown. In this study, we investigated the mechanisms of safranal vasodilation. Methods: Isolated rat endothelium-intact or -denuded aortic rings were precontracted with phenylephrine and then relaxed with safranal. To further assess the involvement of nitric oxide, prostaglandins, guanylate cyclase, and phospholipase A2 in safranal-induced vasodilation, aortic rings were preincubated with L-NAME, indomethacin, methylene blue, or quinacrine, respectively, then precontracted with phenylephrine, and safranal concentration–response curves were established. To explore the effects of safranal on Ca2+ influx, phenylephrine and CaCl2 concentration–response curves were established in the presence of safranal. Furthermore, the effect of safranal on aortic rings in the presence of ouabain, a Na+-K+ ATPase inhibitor, was studied to explore the contribution of Na+/Ca2+ exchanger to this vasodilation. Results: Safranal caused vasodilation in endothelium-intact and endothelium-denuded aortic rings. The vasodilation was not eliminated by pretreatment with L-NAME, indomethacin, methylene blue, or quinacrine, indicating the lack of a role for NO/cGMP. Safranal significantly inhibited the maximum contractions induced by phenylephrine, or by CaCl2 in Ca2+-free depolarizing buffer. Safranal also relaxed contractions induced by ouabain, but pretreatment with safranal totally abolished the development of ouabain contractions. Discussion/Conclusion: Inhibition of Na+-K+ ATPase by ouabain leads to the accumulation of Na+ intracellularly, forcing the Na+/Ca2+ exchanger to work in reverse mode, thus causing a contraction. Inhibition of the development of this contraction by preincubation with safranal indicates that safranal inhibited the Na+/Ca2+ exchanger. We conclude that safranal vasodilation is mediated by the inhibition of calcium influx from extracellular space through L-type Ca2+ channels and by the inhibition of the Na+/Ca2+ exchanger.

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Huang, Xiaocheng, Manlian Zhu, Ying Hua, Xiumei Yan y Ruilai Jiang. "Withdrawn: Safranal induces autophagy by AMPK activation and protects neurons against amyloid beta in Alzheimer’s disease". Tropical Journal of Pharmaceutical Research 18, n.º 3 (12 de mayo de 2021): 459–64. http://dx.doi.org/10.4314/tjpr.v18i3.2.

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This article has been withdrawn by the Editor Purpose: To investigate autophagic induction by safranal and neuroprotection against amyloid beta in Alzheimer’s disease. Methods: Primary neurons and SH-SY5Y cells were used in this study. Assessment of cell proliferation and neuroprotection by safranal against amyloid beta was done by 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. AMPK activation and mTOR inhibition were determined by western blot. Changes in intracellular calcium level, reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were assessed by flow cytometry. Results: Safranal protected neurons against amyloid beta toxicity. Furthermore, safranal activated AMPK pathway by activation of calcium/calmodulin-dependent protein kinase (CaMKKβ) to induce autophagy in both cell lines. The toxicity induced by amyloid beta in primary neurons and SH-SY5Y cells were attenuated by safranal. Moreover, amyloid beta-induced calcium levels were significantly decreased by safranal while ROS and MMP loss produced by amyloid beta was attenuated by safranal. Conclusion: These findings suggest that safranal protects neurons against amyloid beta by inducing autophagy via AMPK pathway. Therefore, safranal is a probable therapeutic target for Alzheimer’s disease.

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Mardani, Hossein, John Maninang, Kwame Sarpong Appiah, Yosei Oikawa, Majid Azizi y Yoshiharu Fujii. "Evaluation of Biological Response of Lettuce (Lactuca sativa L.) and Weeds to Safranal Allelochemical of Saffron (Crocus sativus) by Using Static Exposure Method". Molecules 24, n.º 9 (8 de mayo de 2019): 1788. http://dx.doi.org/10.3390/molecules24091788.

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Safranal, the main volatile chemical of Saffron (Crocus sativus) was studied to estimate its allelopathic effects on the photosynthetic pigment chlorophyll, leaf electrolyte leakage, fresh weight, catalase (CAT), and peroxidase (POX) activity of the test plant Lettuce (Lactuca sativa). In this study, the effective concentration (EC50) of safranal on CAT was estimated to be 6.12 µg/cm3. CAT activity was inhibited in a dose-dependent manner by the increase in the safranal concentration while POX activity was increased. Moreover, Safranal caused significant physiological changes in chlorophyll content, leaf electrolyte leakage, and fresh weight of several weed species with Lolium multiflorum being the most sensitive. Furthermore, 5 µM Safranal showed significant inhibitory activity against dicotyledonous in comparison to the monocotyledons under greenhouse conditions. The inhibition of the CAT by safranal was similar to those of uncompetitive inhibitors, and therefore the decline in carbon fixation by plants might be the mechanism behind the inhibitory activity of safranal.

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Qin-Xiao, Qin-Xiao, Zhan-Jun Lu, Tian-Zi Zhang, Shan-Shan Li, Ting Hua, Suriguga Suriguga, Wen-Lin Chen et al. "Inhibitory effects of safranal on laser-induced choroidal neovascularization and human choroidal microvascular endothelial cells and related pathways analyzed with transcriptome sequencing". International Journal of Ophthalmology 14, n.º 7 (18 de julio de 2021): 981–89. http://dx.doi.org/10.18240/ijo.2021.07.04.

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AIM: To determine the effects of safranal on choroidal neovascularization (CNV) and oxidative stress damage of human choroidal microvascular endothelial cells (HCVECs) and its possible mechanisms. METHODS: Forty-five rats were used as a laser-induced CNV model for testing the efficacy and safety of safranal (0.5 mg/kg·d, intraperitoneally) on CNV. CNV leakage on fluorescein angiography (FA) and CNV thickness on histology was compared. HCVECs were used for a H2O2-induced oxidative stress model to test the effect of safranal in vitro. MTT essay was carried to test the inhibition rate of safranal on cell viability at different concentrations. Tube formation was used to test protective effect of safranal on angiogenesis at different concentrations. mRNA transcriptome sequencing was performed to find the possible signal pathway. The expressions of different molecules and their phosphorylation level were validated by Western blotting. RESULTS: On FA, the average CNV leakage area was 0.73±0.49 and 0.31±0.11 mm2 (P?=?0.012) in the control and safranal-treated group respectively. The average CNV thickness was 127.4±18.75 and 100.6±17.34 μm (P=0.001) in control and safranal-treated group. Under the condition of oxidative stress, cell proliferation was inhibited by safranal and inhibition rates were 7.4%-35.4% at the different concentrations. For tube formation study, the number of new branches was 364 in control group and 35, 42, and 17 in 20, 40, and 80 μg/mL safranal groups respectively (P<0.01). From the KEGG pathway bubble graph, the PI3K-AKT signaling pathway showed a high gene ratio. The protein expression was elevated of insulin receptor substrate (IRS) and the phosphorylation level of PI3K, phosphoinositide-dependent protein kinase 1/2 (PDK1/2), AKT and Bcl-2 associated death promoter (BAD) was also elevated under oxidative stress condition but inhibited by safranal. CONCLUSION: Safranal can inhibit CNV both in vivo and in vitro, and the IRS-PI3K-PDK1/2-AKT-BAD signaling pathway is involved in the pathogenesis of CNV.

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Alavi, Mohaddeseh Sadat, Sahar Fanoudi, Ameneh Veisi Fard, Mohammad Soukhtanloo, Mahmoud Hosseini, Hanif Barzegar y Hamid R. Sadeghnia. "Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury". Drug Research 69, n.º 06 (21 de noviembre de 2018): 323–29. http://dx.doi.org/10.1055/a-0790-8200.

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Abstract Objectives Researches have been shown that glutamic acid (GA) or quinolinic acid (QA) can play role in neuroinflammatory and demyelinating diseases including multiple sclerosis (MS), mainly via oligodendrocytes activation and extreme free radicals generation. Recent studies have demonstrated that safranal, an active constituent of Crocus sativus, has several pharmacological effects such as antioxidant, anti-inflammatory and neuroprotective properties. Since there is no data about the impact of safranal on MS, this study was designed to investigate the protective effect of safranal on OLN-93 oligodendrocytes injury induced by GA or QA. Materials and Methods At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to GA (16 mM) or QA (8 mM) toxicity for 24 h, in which the same treatments were applied. The cell viability and parameters of redox status such as the levels of intracellular reactive oxygen species (ROS) and lipid peroxidation were measured. Results Safranal at concentration ranges of 1–800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following GA or QA insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following GA or QA insults. Conclusion The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.

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ETYEMEZ, Muhammed y Mehmet Şükrü GÜLAY. "The effects of safranal against bisphenol AF on some reproductive parameters in male new zealand rabbits". Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi Erken Görünüm (3 de diciembre de 2022): 0. http://dx.doi.org/10.24880/maeuvfd.1138340.

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Bisphenol AF (BPAF) is used as an analog of the endocrine disruptor BPA, whereas safranal is a powerful antioxidant obtained from the saffron plant. In the current study, the possible effects of BPAF and Safranal on some spermatological parameters, reproductive hormones, oxidant/antioxidant enzymes, and histopathological parameters were investigated. A total of 24 male New Zealand rabbits were divided into 4 groups (n= 6 for each group). The groups and the treatments they received by oral gavage for 9 weeks are as follows: The control group received 1 ml/day of corn oil, the BPAF group received 20 mg/kg/day of bisphenol AF, the Safranal group received 100 mg/kg/day safranal, and the treatment group received 20 mg/kg/day bisphenol AF and 100 mg/kg/day safranal. Although the spermatological parameters prior to the experiment revealed no differences among the groups, BPAF treatment reduced sperm quantity and motility, and elevated seminal plasma estrogen levels at the end of the study. BPAF treatments also had a negative impact on testicular MDA and GSH levels. It also caused seminiferous tubule degeneration in testicular tissue. On the other hand, the administration of safranal with BPAF decreased estrogen levels while increasing sperm concentration and motility to control group levels. Thus, the results suggested that safranal could have a beneficial effect in reducing BPAF-induced tissue damage. In conclusion, BPAF may have potentially harmful to the male reproductive system and safranal may exhibit a protective effect against BPAF exposure.

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Karafakıoğlu, Yasemin Sunucu, Mehmet Fatih Bozkurt, Ömer Hazman y A. Fatih Fıdan. "Efficacy of safranal to cisplatin-induced nephrotoxicity". Biochemical Journal 474, n.º 7 (20 de marzo de 2017): 1195–203. http://dx.doi.org/10.1042/bcj20160971.

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The aim of the present study was to investigate the effects of safranal on cisplatin-induced nephrotoxicity and oxidative stress in rats. Adult male Sprague–Dawley rats were randomly divided into five groups. The control group received physiological saline; animals in Group 2 received only safranal and in Group 3 received only cisplatin; 5 days of safranal treatment was performed following administration of cisplatin for the animals in Group 4; 5 days of safranal pretreatment was applied to the animals in Group 5 before administration of cisplatin. Cisplatin (7 mg/kg) was intraperitoneally injected as a single dose and safranal (200 mg/kg) was administered by gavage. Biochemical and histopathological methods were utilized for evaluation of the nephrotoxicity. The concentrations of creatinine and urea in plasma and levels of malondialdehyde (MDA) and glutathione (GSH) as well as total antioxidant status (TAS) and total oxidant status (TOS) were determined in kidney tissue. Administration of cisplatin to rats induced a marked renal failure, characterized with a significant increase in plasma creatinine and urea concentrations. MDA and TOS levels of rats that received cisplatin alone were not significantly different compared with those of the control group, but GSH and TAS levels in the only cisplatin-administered group were significantly decreased. Safranal administration produced amelioration in biochemical indices of nephrotoxicity in both plasma and kidney tissues when compared with the only cisplatin-administered group, pretreatment with safranal being more effective. As a result, safranal treatment might have a protective effect against cisplatin-induced nephrotoxicity and oxidative stress in rat.

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Deldar, Nafise, Malihezaman Monsefi, Mohsen Salmanpour, Mohadeseh Ostovar y Mojtaba Heydari. "Wound Healing Potential of Crocin and Safranal, Main Saffron (Crocus sativus L.), the Active Constituents in Excision Wound Model in Rats". Galen Medical Journal 10 (5 de febrero de 2021): 1900. http://dx.doi.org/10.31661/gmj.v10i0.1900.

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Background: Saffron is traditionally suggested for wound healing in Persian medicine. It is investigated for wound healing effect in multiple studies with promising results. It is not examined that which ingredient of saffron contributes more to this effect. This study was aimed to evaluate and compare the wound healing potential of saffron and its active constituents, crocin, and safranal, in rats. Materials and Methods: Forty female adult rats with induced excision wounds were randomly divided into four groups to receive topical formulation of saffron, crocin, safranal, and placebo for seven days. The Wound area and histopathologic stage of wound healing were evaluated as outcome measures. Results: The wound area was significantly lower in treatment groups (saffron, crocin, and safranal) compared to the control group on day 7 of the intervention. Compared to the control group, the wound in all treated groups showed a decreased inflammatory response and more progression to the proliferation phase. The saffron group showed more advanced healing phase with complete epithelialization of the wound on day 7 of study when partial and no epithelialization was observed in safranal and crocin groups. Conclusion: The study showed the wound healing properties of both safranal and crocin with the slight superiority of safranal. However, saffron seems to be more potent in wound healing effect compared to safranal and crocin as its main active constituents. [GMJ.2021;10:e1900]

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Tesis sobre el tema "SAFRANALE"

Interlandi, Sebastiano. "Aspetti agronomici innovativi dello zafferano". Thesis, Università degli Studi di Catania, 2011. http://hdl.handle.net/10761/231.

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Lo zafferano (Crocus sativus L.) e' la specie piu' costosa al mondo. In Sicilia e' utilizzato per la produzione del formaggio tipico "Piacentinu ennese" DOP. La coltivazione di questa specie e' stata introdotta nell'isola da pochi anni, per cui e' necessario mettere a punto delle tecniche colturali idonee. L'obiettivo di questo studio e' stato quello di valutare: - l'effetto della grana del terreno sulla produzione di stimmi e bulbi di zafferano; - la produttivita' in coltura poliennale; - la propagazione in vitro. Le prove sono state effettuate nel campo sperimentale dell'Universita' degli Studi di Catania (piana di Catania, a 10 m s.l.m.) ed in un'azienda tipica della Sicilia centrale (720 m slm); la propagazione in vitro e le analisi chimiche, sono state eseguite nei laboratori del CNR "Istituto per i Sistemi Agricoli e Forestali del Mediterraneo (ISAFOM) e "Istituto di Chimica biomolecolare" di Catania. I risultati mostrano che i fiori e la produzione di stimmi, e' legata alla costituzione del terreno ed alle basse temperature verificatesi durante la fioritura. E 'interessante notare che nella coltura poliennale la qualita' del prodotto risulta sempre elevata appartenendo alla prima categoria ISO. Per cio' che concerne la propagazione in vitro e' stata superata la prima fase di sviluppo delle plantule in vitro.

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Puma, Simone Li. "Ruolo dei canali Transient Receptor Potential (TRP) espressi in cellule neuronali e non neuronali, nelle patologie dolorose di origine infiammatoria e neuropatica". Doctoral thesis, 2020. http://hdl.handle.net/2158/1206841.

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The TRPA1 represents a key target in pain modulation. It is manly expressed in primary sensory neurons, where It can be activated by a wide series of exogenous chemicals, and also detects and can be sensitized by a series of endogenous molecules, including oxidative/nitrative/carbonylic stress (ROS/RNS/RCS) byproducts deriving from inflammatory processes. TRPA1 and ROS are emerging as a major pathway in different pain conditions, including migraine headache, which affects almost 15% of the adult worldwide population, with an enormous social and economic cost. In the first study presented here, we examined the effect of the butterbur component [Petasites hybridus (L.)] isopetasin on TRPA1. Butterbur is currently indicated as level A recommendation for migraine prophylaxis by the American Headache Society guidelines, and its major constituents, petasin and isopetasin, are considered responsible for its antimigraine effects. Our results showed that isopetasin is able to gate mouse, rat and human (native and recombinant) TRPA1 channel. In addition, isopetasin acts as a partial agonist on the channel. A chronic treatment in mice with isopetasin showed that this molecule can target TRPA1 and induce desensitization of the channel and defunctionalization of trigeminal nerve terminals, attenuating their ability to release the calcitonin gene-related peptide (CGRP), the main mediator of migraine pain. Successful treatment and prevention with isopetasin, may provide a solid basis for future investigations of TRPA1-tropic approaches for migraine. In the second part, we investigated the possibility that some constituents of saffron [Crocus sativus (L.)] could as well target TRPA1. Saffron has been used for centuries not only for food flavoring and coloring, but also to treat headache in Indian traditional medicine. Furthermore, saffron constituents safranal, crocin and picrocrocin, have been reported to possess analgesic properties in various animal models of pain. We showed that safranal can activate human and rodent TRPA1, acting as a partial agonist. Desensitization experimental protocols in vitro showed that safranal is able to desensitize TRPA1, in a homologous manner. Chronic treatment with safranal in mice confirmed this hypothesis. This mechanism could account for the antinociceptive properties of safranal. Another part of this three years study aimed at investigating glyceryl trinitrate (nitroglycerin, GTN)-induced migraine-like attacks. GTN has long been used as a clinical provocation test for migraine. In most migraineurs, GTN administration evokes headaches that fulfill the criteria of a typical migraine attack. Moreover, GTN administration in rodents and humans induces a delayed and prolonged hyperalgesia, and is able to release the active vasodilator nitric oxide (NO), which is a known TRPA1 agonist. Our study provided evidence that the delayed and prolonged GTN-evoked allodynia in mice is entirely dependent from TRPA1 activation. GTN directly activates TRPA1 in vitro and in vivo (only if given locally). However, systemic treatment with GTN indicated that NO, liberated from GTN by ALDH-2, activates TRPA1 to induce allodynia. By gating TRPA1 in trigeminal nociceptors, NO leads to activation of NOX1/NOX2, which generate ROS and the ensuing aldehyde endproducts. These molecules ultimately activate TRPA1 again, generating an autocrine pathway. TRPA1 antagonists currently in clinical development, or established antimigraine drugs identified as selective channel inhibitors, may be used to verify if a mechanism similar to the present one mediates the effects induced by GTN in migraineurs. Finally, we investigated the possibility that ibuprofen-acyl glucuronide (IAG), a metabolite of ibuprofen, could antagonize TRPA1. Ibuprofen is a classical NSAID, widely used to relieve inflammation and several types of pain, including headache. Its therapeutic effects are attributed to a non-selective, reversible inhibition of COX1 and COX2. 10-15% of ibuprofen is metabolized, through glucuronidation, to IAG, which may covalently bind various macromolecules. Our major finding is that IAG, but not ibuprofen, antagonizes the proalgesic TRPA1 channel. IAG was able, unlike ibuprofen, to selectively inhibit the human and rodent TRPA1 channel. IAG attenuated nociception evoked only by reactive TRPA1 agonists. A systemic administration of ibuprofen also produced a partial attenuation of TRPA1-mediated nociception, probably due to the formation of IAG through liver metabolism. Local IAG produced a more potent anti-inflammatory effect than ibuprofen, attributable to a combination of COX-inhibition and TRPA1-antagonism, since PGE2 levels were ablated by both compounds in the same way. Hence, the analgesic and anti-inflammatory activity of ibuprofen can be attributed to TRPA1 inhibition, in addition to COX inhibition, via IAG generation. The findings of this three years study indicate that TRPA1 expressed in neuronal and non-neuronal cells is a key mediator in inflammatory and neuropathic pain modulation. Our results suggest novel therapeutic approaches to treat pain, in particular migraine, involving TRPA1 antagonists and TRPA1-desensitizing agents.

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PROCHÁZKOVÁ, Michaela. "Mitochondrial gene expression in trypanosomatids". Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-375687.

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This thesis comprises of diverse projects all focused towards analysis of mitochondrial translation in unicellular parasites. As only two mitochondrially encoded genes are required during the life cycle stage when Trypanosoma brucei resides in the bloodstream of a mammalian host, this protist provides a simplified background in which to study mitochondrial translation termination phase. The leading project utilizes T. brucei to examine mitochondrial translation termination factor TbMrf1 by gene knockout. Subsequently, it is suggested that the peptidyl-tRNA hydrolase TbPth4 is able to abate the TbMrf1 knockout phenotype by its ability to rescue mitoribosomes that become stalled when TbMrf1 is absent. Additionally, modifying methyltransferase of TbMrf1, the TbMTQ1, was characterized. And finally, this work contributed to the development of the protein expression regulation method in Leishmania parasites, a protocol for measurement of proton pumping activity of FoF1 ATPase complex in native mitochondria, and optimization of purification protocol for hydrophobic recombinant proteins.

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Libros sobre el tema "SAFRANALE"

Publishers, Museum. Notebook: Ixia Crocata, Tritonia Crocata, Ixia Safranée, Blazing Star, Saffron-Colored Ixia, Redouté, Pierre Joseph, 1759-1840, les Liliacees, 1802 - 1816. Independently Published, 2020.

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Capítulos de libros sobre el tema "SAFRANALE"

Saroha, Asmita y Arpita Ghosh. "Biosorption of Safranine O Dye by SawDust". En Springer Transactions in Civil and Environmental Engineering, 97–105. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-32-9956-6_11.

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Figueira, Tiago R., Daniela R. Melo, Aníbal E. Vercesi y Roger F. Castilho. "Safranine as a Fluorescent Probe for the Evaluation of Mitochondrial Membrane Potential in Isolated Organelles and Permeabilized Cells". En Mitochondrial Bioenergetics, 103–17. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-382-0_7.

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Singh, Priyanka. "Pharmacological Applications of Saffron (Crocus sativus)". En Ethnopharmacological Investigation of Indian Spices, 85–92. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-2524-1.ch006.

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Saffron spice also known as Crocus sativus (Saffron crocus) belongs to the family of iridaceae. Many studies have proved its potential role in disease eradication. It has been reported to possess the attributes of a sedative, an anti-asthma, an emmenagogue, an expectorant, and an adaptogenic agent. Crocin, crocetin, and safranal are the most important biochemically active ingredients that were found in different parts of the plants in varying proportions like the peels, fruits, seeds, and rind of Crocus sativus. The in vitro and in vivo studies showed that saffron has got its therapeutic implication in health management via anti-oxidant, anti-microbial, hepatoprotective, and anti-tumour activity. This review attempts to reveal the potential pharmacological properties of Crocus sativus. It also draws attention towards the use of herbs and spices in various ailments without facing the harmful side effects of chemically derived medicine.

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Actas de conferencias sobre el tema "SAFRANALE"

Wang, Junbo, Li Wang, Long Chen, Yujie Niu, Li Xie y Bing Xu. "A Novel Wastewater Treatment of Safranine T by Electrochemical Polymerization Method". En 2017 3rd International Forum on Energy, Environment Science and Materials (IFEESM 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/ifeesm-17.2018.268.

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Song, Shuang, Long Fan, Shuyuan Xie, Jinghai Liu y Limei Duan. "Photocatalytic Heteropolyacid/CdS (HPA/CdS) Composite for Degradation of Safranine T (ST)". En International Conference on Advances in Energy, Environment and Chemical Engineering. Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/aeece-15.2015.52.

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Maity, Subhasis y Nabin Baran Manik. "Safranine T dye based photo electrochemical solar cell: Effect of electrodes on device mechanism". En 2007 International Workshop on Physics of Semiconductor Devices. IEEE, 2007. http://dx.doi.org/10.1109/iwpsd.2007.4472584.

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Tahri, K., M. Bougrini, T. Saidi, C. Tiebe, N. El Alami-El Hassani, N. El Bari, T. Hubert y B. Bouchikhi. "Determination of safranal concentration in saffron samples by means of VE-Tongue, SPME-GC-MS, UV-Vis Spectrophotometry and multivariate analysis". En 2015 IEEE Sensors. IEEE, 2015. http://dx.doi.org/10.1109/icsens.2015.7370179.

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Jasim, Mohammed Ahmed, Ahmed Mohammed Abbas y Israa Mohammed Radhi. "Preparation and characterization of biomass-alumina composite as adsorbent for safranine-o dye from aqueous solution at different temperatures". En PROCEEDINGS OF THE III INTERNATIONAL CONFERENCE ON ADVANCED TECHNOLOGIES IN MATERIALS SCIENCE, MECHANICAL AND AUTOMATION ENGINEERING: MIP: Engineering-III – 2021. AIP Publishing, 2021. http://dx.doi.org/10.1063/5.0068746.

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Solanki, Prem Prakash y K. M. Gangotri. "Studies of the Anionic Micelles Effect on Photogalvanic Cells for Solar Energy Conversion and Storage in Sodium Lauryl Sulphate-Safranine-D-Xylose System". En World Renewable Energy Congress – Sweden, 8–13 May, 2011, Linköping, Sweden. Linköping University Electronic Press, 2011. http://dx.doi.org/10.3384/ecp110572807.

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