Bibliografías temáticas / Safety outcome

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Literatura académica sobre el tema "Safety outcome"

Autor: Grafiati
Publicado: 11 de marzo de 2023

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Artículos de revistas sobre el tema "Safety outcome"

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Easter, Kathy y Linda M. Tamburri. "Understanding Patient Safety and Quality Outcome Data". Critical Care Nurse 38, n.º 6 (1 de diciembre de 2018): 58–66. http://dx.doi.org/10.4037/ccn2018979.

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The need for nurses to understand patient safety and quality outcome data is pressing in the current era of data transparency. Health care outcomes data are now publicly reported and readily accessible to consumers, are necessary for performance-based reimbursement, and are required by government and regulatory agencies. In order for nurses at all levels of practice to own their outcomes and be accountable for making improvements, they must possess skills in collecting, analyzing, evaluating, and acting on outcome data. This article provides basic tools and clinical examples for nurses to use in a focused application of outcome data and a structured process for improving nursing care outcomes.
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Hicks, Gemma, Donna Buttigieg y Helen De Cieri. "Safety climate, strain and safety outcomes". Journal of Management & Organization 22, n.º 1 (7 de diciembre de 2015): 19–31. http://dx.doi.org/10.1017/jmo.2015.45.

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AbstractThe purpose of this study is to employ Koeske and Koeske’s stressor-strain-outcome model of stress to examine the extent to which strain, a central component of occupational stress, mediates the relationship between safety climate and safety-related outcomes. The relationship between safety climate, strain and safety outcomes has been relatively under tested where strain is a mediating variable. This study makes a contribution to the literature by examining the dynamics of these relationships. Questionnaires were sent to 1,800 employees of an electricity provider, with a 41.4% response rate. The hypothesized model was tested using structural equation modeling. Analysis of the hypothesized model indicated that, while safety climate had a significant direct relationship with safety-related behaviors, the model was also partially mediated by the experience of strain. Understanding the relationship between safety climate, strain and safety outcomes is important. Support for the model verifies that safety climate is mediated by strain in terms of safety outcomes. Practical implications include the need to manage safety climate through management attitudes to safety, maintaining high safety standards and communication to reduce ambiguity on safety norms.
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Dinesh, H. N., Ravya R. S. y Sunil Kumar V. "Surgical safety checklist implementation and its impact on patient safety". International Surgery Journal 5, n.º 11 (26 de octubre de 2018): 3640. http://dx.doi.org/10.18203/2349-2902.isj20184637.

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Background: Surgery has become an integral part of global health care, with an estimated 234 million operations performed yearly. Surgical complications are common and often preventable. Although surgical and anesthetic caregivers seek to deliver optimal quality in peri-operative service, surgery still carries considerable risk for the patient. WHO surgical safety checklist outlines essential standards of surgical care and has been shown to reduce complications and death associated with surgery.Methods: Pre-intervention and post-intervention study. The effect on patient outcomes and documentation of WHO surgical safety checklist was examined. After an education programme, the checklist implementation and patient safety outcome indicators were studied.Results: Checklist compliance increased over time. The median number of items documented was 16. After implementation of the checklist, mortality decreased from 3.13% to 2.85%. Most causes of death did not significantly differ between the implementation periods, except for multiorgan failure and major bleeding. Adjustment of the association between implementation period and outcome for all variables revealed a decreased mortality after checklist implementation.Conclusions: Implementation of the checklist showed improved outcomes. Use of the WHO surgical safety checklist in urgent operations is feasible and should be considered. Implementation proved neither costly nor lengthy. Further research is needed to confirm these findings and reveal additional factors supportive of checklist implementation.
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Abdul Kadir, A. Z., Jafri Mohd Rohani y Matthew Oluwole Arowolo. "Road Safety Outcome Model among Commercial Bus". Advanced Materials Research 1125 (octubre de 2015): 546–50. http://dx.doi.org/10.4028/www.scientific.net/amr.1125.546.

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Road safety outcome is a complex issue involving high number of risk factors and indicators that contributes to road accidents and their severity related to human-vehicle–road interactions. This requires a multi-dimensional model in order to fully understand the road safety situation especially among commercial bus drivers. This study identified some of the risk factors with the objective of establishing the relationship between them through a model for assessing the road safety outcome. The model was developed using data collected from 465 commercial bus drivers in Johor, Malaysia. The estimated model yielded significant relationship between the risk factors (Drivers, Vehicle and Road) and road safety outcomes. The statistical analysis of these risk factors shows that the model has significant fit to the data. The results therefore, yielded a road safety output guideline formula suitable for road safety performance indicator for safety practitioners and stakeholders. The study pointed out three critical risk factors (e.g. Drivers, Vehicle and Road) with their various levels of risk contributions as influence on road safety among commercial bus. Six recommendations based on this finding were made in an attempt to reduce commercial bus accidents.
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Lee, Seung Eun y Brenna L. Quinn. "Safety Culture and Patient Safety Outcomes in East Asia: A Literature Review". Western Journal of Nursing Research 42, n.º 3 (23 de mayo de 2019): 220–30. http://dx.doi.org/10.1177/0193945919848755.

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This review examined associations between safety culture aspects and patient safety outcomes in East Asian hospitals and identified relevant research priorities. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, 16 articles were identified for review. Patient safety nursing activity was the most commonly investigated outcome in relation to safety culture aspects. Among safety culture aspects, feedback and communication, frequency of event reporting, teamwork within units, and managers’ support for patient safety were most significantly related to patient safety outcomes. Areas for further research include the use of theory or theoretical frameworks, consensus upon the scoring strategies for computation of safety culture scores, and selecting appropriate units of analysis and statistical analyses. Finally, researchers should examine relations between unit-specific and nation-specific safety culture and patient safety outcomes, given the influence of cultural attitudes and behaviors on patient safety.
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de Vries, Friso, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth y Nienke R. Biermasz. "Outcome Squares Integrating Efficacy and Safety, as Applied to Functioning Pituitary Adenoma Surgery". Journal of Clinical Endocrinology & Metabolism 106, n.º 9 (6 de marzo de 2021): e3300-e3311. http://dx.doi.org/10.1210/clinem/dgab138.

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Abstract Context Transsphenoidal surgery is standard care in the treatment of hormone-secreting pituitary adenomas. Current clinician-reported surgical outcome measures are one-dimensional, typically focusing primarily on complete or partial resection, and secondarily on complication rates. However, outcomes are best reflected by the delicate balance of efficacy and complications at patient level. Objective This study proposes a novel way to classify and report outcomes, integrating efficacy and safety at the patient level. Methods Retrospective chart review of all pure endoscopic transsphenoidal surgical procedures for acromegaly, Cushing’s disease, and prolactinoma between 2010 and 2018 in a single tertiary referral center. We present our results in a classic (remission and complications separate) and in a novel outcome square integrating both outcomes, focusing on intended and adverse effects (long-term complications). This resulted in 4 outcome groups, ranging from good to poor. We use this approach to present these outcomes for several subgroups. Results A total of 198 surgical procedures were included (44 reoperations). Remission was achieved in 127 operations (64%). Good outcome was observed after 121 (61%), and poor outcome after 6 (3%) operations. When intended effect of surgery was applied (instead of remission), good outcome as intended was achieved after 148 of 198 surgeries (75%) and poor outcome after 4 (2%). Conclusion Quality of a surgical intervention can be presented in 4 simple categories, integrating both efficacy and safety with flexibility to adapt to the individualized situation at patient, disease, and surgical strategy and to the outcome of interest.
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Collares, Felipe Birchal, Mehru Sonde, Kenneth Harper, Michael Armitage, Diana L. Neuhardt y Helane S. Fronek. "Patient safety in phlebology: The ACP Phlebology Safety Checklist". Phlebology: The Journal of Venous Disease 33, n.º 4 (23 de febrero de 2017): 273–77. http://dx.doi.org/10.1177/0268355517694725.

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Objectives To assess the current use of safety checklists among the American College of Phlebology (ACP) members and their interest in implementing a checklist supported by the ACP on their clinical practices; and to develop a phlebology safety checklist. Method Online surveys were sent to ACP members, and a phlebology safety checklist was developed by a multispecialty team through the ACP Leadership Academy. Results Forty-seven percent of respondents are using a safety checklist in their practices; 23% think that a phlebology safety checklist would interfere or disrupt workflow; 79% answered that a phlebology safety checklist could improve procedure outcomes or prevent complications; and 85% would be interested in implementing a phlebology safety checklist approved by the ACP. Conclusion A phlebology safety checklist was developed with the intent to increase awareness on patient safety and improve outcome in phlebology practice.
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Zhu, Motao, Susan B. Hardman y Lawrence J. Cook. "Backseat safety belt use and crash outcome". Journal of Safety Research 36, n.º 5 (enero de 2005): 505–7. http://dx.doi.org/10.1016/j.jsr.2005.10.014.

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Traboulsee, Anthony L., Lindsay Machan, J. Marc Girard, Jean Raymond, Reza Vosoughi, Brian W. Hardy, Francois Emond et al. "Safety and efficacy of venoplasty in MS". Neurology 91, n.º 18 (28 de septiembre de 2018): e1660-e1668. http://dx.doi.org/10.1212/wnl.0000000000006423.

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ObjectiveTo determine the safety and efficacy of balloon vs sham venoplasty of narrowing of the extracranial jugular and azygos veins in multiple sclerosis (MS).MethodsPatients with relapsing or progressive MS were screened using clinical and ultrasound criteria. After confirmation of >50% narrowing by venography, participants were randomized 1:1 to receive balloon or sham venoplasty of all stenoses and were followed for 48 weeks. Participants and research staff were blinded to intervention allocation. The primary safety outcome was the number of adverse events (AEs) during 48 weeks. The primary efficacy outcome was the change from baseline to week 48 in the patient-reported outcome MS Quality of Life–54 (MSQOL-54) questionnaire. Standardized clinical and MRI outcomes were also evaluated.ResultsOne hundred four participants were randomized (55 sham; 49 venoplasty) and 103 completed 48 weeks of follow-up. Twenty-three sham and 21 venoplasty participants reported at least 1 AE; one sham (2%) and 5 (10%) venoplasty participants had a serious AE. The mean improvement in MSQOL-54 physical score was +1.3 (sham) and +1.4 (venoplasty) (p = 0.95); MSQOL-54 mental score was +1.2 (sham) and −0.8 (venoplasty) (p = 0.55).ConclusionsOur data do not support the continued use of venoplasty of extracranial jugular and/or azygous venous narrowing to improve patient-reported outcomes, chronic MS symptoms, or the disease course of MS.ClinicalTrials.gov identifierNCT01864941.Classification of evidenceThis study provides Class I evidence that for patients with MS, balloon venoplasty of extracranial jugular and azygous veins is not beneficial in improving patient-reported, standardized clinical, or MRI outcomes.
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Vergeire-Dalmacion, Godofreda. "The Safety of Dengvaxia and Should Hospitalization be an Outcome for its Clinical Trial?" Pharmaceutics and Pharmacology Research 1, n.º 1 (8 de octubre de 2018): 01–02. http://dx.doi.org/10.31579/2693-7247/003.

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The uncertainties on the efficacy and safety of Dengvaxia continue to haunt doctors, parents, and lawmakers alike in the Philippines. After the mass immunization of about 850,000 children with Dengvaxia, there has been a continuing report of deaths, unofficially 29 to date among those who received the vaccine between 2016-2017. Countries in the Asia Pacific region, including the Philippines, were one of the sites for the Dengvaxia Clinical Trial. In 2014, the Efficacy Trial of Dengvaxia covering the period after completion of the 3 doses up to the 28th day was published by Capeding, et al. An overall efficacy rate of 56.5% was reported but it can be misleading since the efficacy rates for each serotype varied widely. The uncertainties on the efficacy and safety of Dengvaxia continue to haunt doctors, parents, and lawmakers alike in the Philippines. After the mass immunization of about 850,000 children with Dengvaxia, there has been a continuing report of deaths, unofficially 29 to date among those who received the vaccine between 2016-2017. Countries in the Asia Pacific region, including the Philippines, were one of the sites for the Dengvaxia Clinical Trial. In 2014, the Efficacy Trial of Dengvaxia covering the period after completion of the 3 doses up to the 28th day was published by Capeding, et al. An overall efficacy rate of 56.5% was reported but it can be misleading since the efficacy rates for each serotype varied widely. The uncertainties on the efficacy and safety of Dengvaxia continue to haunt doctors, parents, and lawmakers alike in the Philippines. After the mass immunization of about 850,000 children with Dengvaxia, there has been a continuing report of deaths, unofficially 29 to date among those who received the vaccine between 2016-2017. Countries in the Asia Pacific region, including the Philippines, were one of the sites for the Dengvaxia Clinical Trial. In 2014, the Efficacy Trial of Dengvaxia covering the period after completion of the 3 doses up to the 28th day was published by Capeding, et al. An overall efficacy rate of 56.5% was reported but it can be misleading since the efficacy rates for each serotype varied widely.
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Tesis sobre el tema "Safety outcome"

1

Rook, Mieneke. "Living kidney donor safety insights & outcome /". [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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RinaldiFuller, Julie. "Patient to nurse ratios and safety outcomes for patients". [Denver, Colo.] : Regis University, 2008. http://165.236.235.140/lib/JRinaldiFuller2008.pdf.

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Deng, Lucy. "Seizures following vaccination: risk, outcome and recurrence". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27195.

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Background An adverse event following immunisation is any untoward medical occurrence that follows immunisation and does not necessarily have a causal relationship with the usage of the vaccine. Seizures, ranging from the common and mostly benign febrile seizure to the life-threatening status epilepticus, that occur following immunisation are considered adverse events following immunisation. Febrile seizures have been observed to occur in defined periods following vaccination when a fever is most likely to occur. The magnitude of risk attributed to specific vaccines varies, with no known increased risk seen for some vaccines. Status epilepticus, continuous seizure activity for 5 minutes or more without return of consciousness, or recurrent seizure activity without a return to baseline consciousness in between, has also been reported following vaccination, though the magnitude of attributable risk is unclear. Both seizure types are rare, but serious adverse events, that can follow and sometimes be triggered by immunisation. Because of the potential risk of neurodevelopmental sequalae, seizures can affect both provider and consumer confidence in vaccine safety and therefore immunisation coverage. Knowledge gaps on seizures following vaccination include their clinical severity, developmental outcomes, genetic risks and revaccination outcomes. In my thesis, I aimed to address these gaps to better inform immunisation providers about the risks and outcomes of these potentially serious adverse events following immunisation, to improve guidance on their assessment and management, and ultimately to improve parent and consumer confidence in vaccine safety. Febrile seizures following vaccination In this thesis, I set out to assess the clinical severity, neurodevelopmental outcome and genetic risk of febrile seizures following vaccination, to supplement the known attributable risk of febrile seizures following specific vaccines. Vaccine proximate seizures were defined as VPS was defined as a seizure within 14 days of a vaccination encounter, based on previous studies on the timing of fever and febrile seizures following specific vaccines. I examined the clinical severity of vaccine-proximate febrile seizures through a multi-site prospective cohort study. I discovered that febrile seizures most commonly occurred following the first dose of measles-containing vaccine, and were not clinically any different to febrile seizures due to another cause such as a viral illness. The only factor that prolonged hospitalisation in children with a vaccine-proximate febrile seizure was the presence of concomitant laboratory-confirmed infection. A subsequent prospective case-control study was conducted to assess developmental and behavioural outcomes, and to identify the presence of genetic variants in children with vaccine-proximate febrile seizures compared to children with non-vaccine-proximate febrile seizures and no history of seizures. Using standardised developmental tests administered by certified assessors blinded to the child’s medical history and standardised parent-completed questionnaires, this study found no increased risk of developmental or behavioural problems in children with vaccineproximate febrile seizures compared to children with non-vaccine-proximate seizures or no history of seizures. Genetic variants in the sodium channel gene, SCN1A, associated with a severe form of epilepsy were only identified in children with prolonged vaccine-proximate febrile seizures. Status epilepticus following vaccination Prior to this thesis, there were only case reports and case series on vaccine-proximate status epilepticus, presenting an incomplete and potentially biased picture of the risk and severity of vaccineproximate status epilepticus that may not be generalisable to the whole population. Using a retrospective, population-based, record-linked cohort linking birth, immunisation, hospitalisation and death data, I was able to determine that less than 4% of first episode status epilepticus in children was vaccine proximate. Similar to vaccine-proximate febrile seizures, status epilepticus was found to occur most commonly following the first dose of measles-containing vaccine, but at a rate 35 times lower than that of vaccine-proximate febrile seizure for the same risk window. There was no difference in clinical severity, measured by duration of hospitalisation, intensive care unit admission or death, between vaccine-proximate and non-vaccine-proximate status epilepticus cases. The predictor for ongoing seizures subsequent to the first status epilepticus was seizure onset prior to the status epilepticus episode. Importantly, vaccination uptake decreased following status epilepticus, regardless of the proximity of the status epilepticus episode to vaccination. These findings were confirmed in a second retrospective cohort study I conducted using medical record review to validate the findings from the larger population-based retrospective study that relied on hospital administrative data. The retrospective cohort study also found morbidity following vaccine-proximate status epilepticus was associated with the presence of an underlying genetic epilepsy, where the seizures are the result of a known or presumed genetic defect. Revaccination outcomes following vaccine-proximate seizures Following the identification of the risk and outcome of seizures following vaccination, the next logical clinical question to address was can these children safely proceed with subsequent vaccinations and, if so, how? I, therefore, examined the risk of seizure recurrence following revaccination in children with a previous vaccine-proximate seizure. Through a 5-year multi-site retrospective cohort study, I reviewed the clinical management and outcomes of children with a history of vaccine-proximate seizures who presented to a Specialist Immunisation Clinic, a specialist clinic at tertiary paediatric hospitals where children with a vaccine proximate seizure are provided specialised medical assessment and management for subsequent vaccinations. Vaccine-proximate seizure recurrence was found to be more likely in children with an underlying genetic epilepsy, in particular Dravet syndrome. Reassuringly, the risk of seizure recurrence decreased with the use of prophylactic benzodiazepine with vaccination in these children. Conclusions Vaccination is one of the most effective public health measures for reducing the burden of infectious diseases. However, the success of vaccination programs has been threatened by vaccine hesitancy, that is, the reluctance or refusal to vaccinate despite vaccine availability. Concerns regarding the safety of vaccines and their potential long-term neurological sequalae are amongst the complex reasons why people choose not to vaccinate. My doctoral research has contributed to vaccine safety knowledge globally, specifically in the understanding of seizures, specifically febrile seizures and status epilepticus, as severe acute neurological events following vaccination. In this thesis, I not only identified the children most at risk of neurological sequelae following a vaccine-proximate seizure, but also a revaccination management plan that would allow these children to continue vaccinations without placing them at risk of further vaccine-proximate seizures. These are children aged <12 months, whose underlying genetic epileptic encephalopathy is unmasked by a vaccination event. These children typically present with status epilepticus following vaccination, and are most likely to have further seizures with revaccination if it is given without additional precautions in the form of prophylactic benzodiazepine. My thesis finding highlights the importance of, and future work required to better understand, adversomics – the immunogenetics and immunogenomics of vaccine adverse events at the individual and population level, respectively – and its implications on vaccine safety, confidence and uptake. Finally, my thesis incorporates a variety of research methods, from retrospective record-linked cohort studies to examine whole-of-population risk, retrospective multi-site clinic-based cohort studies to examine detailed clinical management and outcomes, and prospective case-control studies to test hypotheses. I have demonstrated the unique contribution of each of these research methods and the strength in combining these to form a broader pharmacovigilance program of research that can help inform both risk and outcome at a population and individual level. By applying the doctoral research skills I have acquired, I aim to continue my work as a vaccine safety clinician researcher in the monitoring and investigation of vaccine safety signals for novel vaccines, including the multiple COVID-19 vaccines currently in early use globally, to ensure the continued safe and effective use of vaccines in the years to come.
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Arun, Ashutosh. "A novel Road User Safety Field Theory for traffic safety assessment applying video analytics". Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/234039/1/Ashutosh_Arun_Thesis.pdf.

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This thesis introduces a new Road User Safety Field Theory to proactively assess traffic safety by studying the interactions of various road users at signalised intersections. The proposed theory combines road traffic environmental factors, vehicle capabilities and personal characteristics to determine the extent and strength of road users’ safety ‘bubble’ or field across various traffic interactions. By applying the Artificial Intelligence-based video data analytics, the proposed Road User Safety Field Theory is found to better estimate crash risks in terms of crash frequency and severity than traditional traffic conflict techniques.
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Murray, Brett Richard. "The use of emergency lights and sirens by ambulances and their effect on patient outcome and public safety". Thesis, Boston University, 2013. https://hdl.handle.net/2144/21225.

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Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
The use of emergency lights and sirens as warning devices by ambulances is a hotly debated topic within the Emergency Medical Services. For the last few decades, research has shown that lights and sirens have only a minimal effect on time required to transport patients to the hospital, and essentially no positive effect on patient outcome. Meanwhile, thousands of ambulance crashes occur every year (usually during the operation of lights and sirens), and its possible that's tens of thousands of crashes are occurring as a result of a passing ambulance, though not directly involving the ambulance itself. This paper is meant to provide a thorough review of the science behind the use of lights and sirens, the risks they pose to EMS providers, patients, and the public, and strategies to help curb the cost they pose both in dollars and lives. The available literature on this subject all points to the use of lights and sirens being out dated, ineffective, and dangerous, and yet almost nothing has been done to solve the problems they cause. Continued research and development is needed to help make ambulances safer for their occupants, more effective driver training programs need to be offered to EMS providers, and protocols need to be adopted to limit the unnecessary use of L&S.
2031-01-01
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6

Hakalahti, A. (Antti). "Efficacy and safety of radiofrequency catheter ablation in the treatment of atrial fibrillation". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209500.

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Abstract Atrial fibrillation (AF) is a common arrhythmia in the clinical setting with a population prevalence of 1–2%. AF significantly increases the risk of stroke and death, worsens coexistent heart diseases and may leave the patient with disabling symptoms. The treatment of AF consists of the control of the underlying conditions, prevention of complications and symptom relief by controlling heart rate (rate control) or by targeting normal rhythm (rhythm control), with the latter achieved either by antiarrhythmic drug (AAD) therapy or catheter ablation (CA). Ablation therapy has generally been applied and studied after failure of AAD therapy. The aim of this study was to evaluate the safety and efficacy of first-line CA in AF. The other objectives were to assess the safety of continuous warfarin therapy during CA and to identify prognostic markers for treatment outcome. A meta-analysis of all randomised studies and a secondary analysis of one randomised study comparing CA and AAD as first-line therapy were performed. In the first study, ablation therapy reduced AF recurrences more than AAD therapy (HR 0.63) when provided as first-line therapy; the rate of complications was similar with both therapies. Some of the complications of ablation therapy were more serious than those encountered with AADs. The second study revealed that the antiarrhythmic efficacy of ablation therapy was more durable. In the third study, the efficacies of continuous and interrupted warfarin therapy were compared in 228 procedures; both strategies were found to be equally safe during a three month follow-up. Furthermore, an analysis of 2317 AF episodes revealed a new electrocardiographic feature at AF initiation, which was associated with AF relapse after the initiation of therapy. Finally, a thorough echocardiographic examination was performed in 49 patients prior to ablation therapy. Mild diastolic dysfunction was associated with AF recurrence. In conclusion, CA was more effective as a first-line therapy than AADs but may cause more severe complications. Continuous warfarin therapy was found to be safe during CA. New electrocardiographic and echocardiographic markers for treatment outcome were recognised
Tiivistelmä Eteisvärinä on yleinen rytmihäiriö, jonka esiintyvyys väestössä on 1–2 % luokkaa. Eteisvärinä lisää merkittävästi kuolleisuutta ja aivoinfarktiriskiä, vaikeuttaa muiden sydänsairauksien oireita ja saattaa aiheuttaa invalidisoivia oireita. Eteisvärinän hoito keskittyy liitännäissairauksien hoitoon ja komplikaatioiden estoon sekä oireiden lievitykseen joko syketaajuutta säätämällä (sykkeenhallinta) tai pyrkimällä normaaliin rytmiin (rytminhallinta). Rytminhallinnassa käytetään yleisesti joko rytmihäiriölääkkeitä tai katetriablaatiohoitoa. Eteisvärinän katetriablaatiota on useimmiten käytetty ja tutkittu tilanteessa, jossa rytmihäiriölääkitys on osoittautunut tehottomaksi. Tämän tutkimuksen tavoitteena oli arvioida eteisvärinän katetriablaatiohoidon tehoa ja turvallisuutta ensilinjan hoitona. Muina tavoitteina oli katetriablaation turvallisuuden arviointi jatkuvan varfariinihoidon aikana sekä löytää uusia katetriablaatiohoidon tehoa ennustavia tekijöitä. Teimme meta-analyysin kaikista randomisoiduista tutkimuksista ja sekundaarisen analyysin yhdestä randomisoidusta tutkimuksesta, jotka vertasivat rytmihäiriölääke- ja katetriablaatiohoitoa ensilinjan hoitona. Ensimmäisessä työssä ablaatiohoito esti eteisvärinän uusiutumista tehokkaammin (riskisuhde 0.63), eikä komplikaatioiden yleisyydessä ollut eroa hoitojen välillä. Jotkut ablaatiohoitoon liittyvät komplikaatiot olivat kuitenkin luonteeltaan vakavampia kuin lääkehoidossa. Ablaatiohoidon eteisvärinää estävä vaikutus todettiin pidempikestoiseksi toisessa työssämme. Kolmannessa työssä vertasimme jatkuvaa ja tauotettua varfariinihoitoa 228 ablaatiotoimenpiteen aikana. Molemmat lähestymistavat osoittautuivat yhtä turvallisiksi 3 kuukauden seuranta-aikana. Analysoimme edelleen 2317 eteisvärinäkohtausta ja löysimme osalla potilaista uuden eteisvärinäkohtauksen alkuun liittyvän ominaisuuden, joka oli yhteydessä rytminhallinnan tehottomuuteen. Lisäksi teimme 49 potilaalle laajan sydämen ultraäänitutkimuksen ennen katetriablaatiotoimenpidettä. Diastolisen dysfunktion havaittiin olevan yhteydessä eteisvärinän uusiutumiseen. Yhteenvetona totesimme että katetriablaatiohoito on rytmihäiriölääkehoitoa tehokkaampaa ensilinjan hoitona, mutta siihen mahdollisesti liittyvät komplikaatiot olivat luonteeltaan hankalampia. Jatkuva varfariinihoito todettiin turvalliseksi katetriablaation yhteydessä. Löysimme lisäksi sydänsähkökäyrästä ja sydämen ultraäänitutkimuksesta uusia hoidon tehoa ennustavia tekijöitä
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Nelms, Mark David. "Development of in silico models to support repeat dose safety assessment of cosmetic ingredients to humans". Thesis, Liverpool John Moores University, 2015. http://researchonline.ljmu.ac.uk/4424/.

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Cosmetic products are used daily on a global scale. Therefore, it is necessary to ensure that these products, and their ingredients, do not cause any adverse human health effects under normal usage; to ensure this, risk assessment must be performed. Traditionally, risk assessments are performed in vivo, i.e. conducting tests on animals using the chemical(s) of interest. However, over the past decade there has been an increase in research into the use of alternative toxicity testing methods, such as in vitro, in chemico and in silico. Whilst there are a number of alternative techniques that may be employed, no one method can be used in isolation as a full replacement for an in vivo test. Therefore, the Adverse Outcome Pathway (AOP) concept is an emerging method by which information provided by the in vitro, in chemico, and in silico approaches can be utilised in an integrated testing strategy. The AOP concept links an upstream molecular initiating event to a downstream adverse outcome, via a number of testable key events. In silico approaches utilise computers in order to develop predictive models. Within the AOP paradigm in silico method work to identify the key features of a chemical (structural alerts) that induce a molecular initiating event (MIE). A collection of structural alerts that induce the same MIE are considered to be an in silico profiler. Typically, these in silico profilers are supported by associated toxicity, or mechanistic, information pertaining to the ability to induce a specific MIE. The overall aim of the work presented in this thesis was the development of an in silico profiler, based upon the hypothesis that the induction of mitochondrial toxicity is a key driver of organ-level toxicity. The research presented herein demonstrates the ability to identify, and develop, two types of structural alert; mechanism- and chemistry-based; that pertain to mitochondrial toxicity. Due to the differences inherent in these two types of alert they should be utilised for different purposes. As such, the main usage of the mechanism-based alerts should be in the formation of chemical categories and subsequent data gap filling via read-across. In comparison, the chemistry-based alerts should be utilised for the purposes of prioritising chemicals, within an inventory, that should undergo additional testing in in vitro and/or in chemico assays. It is envisaged that these two types of structural alerts could be used to profile chemical inventories as part of a tiered testing strategy. Therefore, the future work discussed in detail the need to expand the chemical space covered by the alerts. Additional future work involves utilising experimental information from in vitro/in chemico assays to verify the mechanism-based alerts and to refine the chemistry-based alerts by discerning mechanistic information associated with them. Furthermore, it is envisaged that these alerts could be incorporated into predictive tools, such as the OECD QSAR Toolbox, to enable their use for screening and prioritisation purposes.
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Bunch, Jacinda Lea. "Rapid response systems : evaluation of program context, mechanism, and outcome factors". Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/1558.

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Prevention of in-hospital cardiac arrest (IHCA) is critical to reducing morbidity and mortality as both the rates of return to pre-hospital functional status and overall survival after IHCAs are low. Early identification of patients at risk and prompt clinical intervention are vital patient safety strategies to reduce IHCA. One widespread strategy is the Rapid Response System (RRS), which incorporates early risk identification, expert consultation, and key clinical interventions to bedside nurses caring for patients in clinical deterioration. However, evidence of RRS effectiveness has been equivocal in the patient safety literature. This study utilized a holistic Realistic Evaluation (RE) framework to identify important clinical environment (context) and system triggers (mechanisms) to refine our understanding of an RRS to improve local patient emoutcomesem and develop a foundation for building the next level of evidence within RE research. The specific aims of the study are to describe a RRS through context, mechanism, and outcome variables; explore differences in RRS outcomes between medical and surgical settings, and identify relationships between RRS context and mechanism variables for patient outcomes. Study RRS data was collected retrospectively from a 397-bed community hospital in the Midwest; including all adult inpatient RRS events from May 2006 (2 weeks post-RRS implementation) through November 2013. RRS events were analyzed through descriptive, comparative, and proportional odds (ordinal) logistic regression analyses. The study found the majority of adult inpatient RRS events occurred in medical settings and most were activated by staff nurses. Significant differences were noted between RRS events in medical and surgical settings; including patient status changes in the preceding 12 hours, event trigger patterns, and immediate clinical outcomes. Finally, proportional odds logistic regression revealed significant relationships between context and mechanism factors with changes in the risk of increased clinical severity immediately following at RRS event. RE was utilized to structure a preliminary study to explore the complex variables and relationships surrounding RRSs and patient outcomes. Further exploration of settings, changes in clinical status, staffing and resource access, and the ways nurses use RRSs is necessary to promote the early identification of vulnerable patients and strengthen hospital patient safety strategies.
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Walker, Hattie R. "An analysis of the safety outcome of children in the in-home supervision and out-of-home care". DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1997. http://digitalcommons.auctr.edu/dissertations/1346.

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The purpose of this study was to compare the safety outcome for children who remained at home under the supervision of the State and children who were placed in foster care. There were two variables: (1) services as the independent variable, and (2) placement outcomes as the dependent variable. A correlational research design was used to analyze the data. An on-site review instrument was used to collect data from three county Departments of Social Services in South Carolina. Additionally, a case record analysis and a face-to-face interview approach were utilized. The conclusion drawn from this study is that families are confronted with many stressors and a lack of resources that affect their behavior. The researcher found that in cases where services were provided, maltreated children could remain safely in their homes. For future child maltreatment interventions, this could provide a comprehensive approach to services that might avoid unnecessary out-of-home placements.
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Bonner, Alice F. "Certified Nursing Assistants’ Perceptions of Nursing Home Patient Safety Culture: Is There a Relationship to Clinical or Workforce Outcomes?: A Dissertation". eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsn_diss/10.

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Patient safety culture (PSC) is a critical factor in creating high reliability healthcare organizations. However, few studies to date have correlated PSC measures with actual safety outcomes. In particular, nursing home studies have only recently appeared in the literature. Nursing homes differ from hospitals in that the vast majority of direct care is provided by certified nursing assistants (CNAs), not licensed nurses. Thus nursing home PSC could differ in important ways from PSC in acute care institutions. This dissertation was a secondary data analysis that examined whether CNAs’ perceptions of patient safety culture were correlated with clinical outcomes in a random sample of 74 nursing homes in five randomly selected states. This study matched CNA PSC survey data using the Hospital Survey of Patient Safety Culture (HSOPSC) with Minimum Data Set (MDS), Area Resource File (ARF) and Online Survey Certification and Reporting (OSCAR) data from those same homes during the first two quarters of 2005. In the original study, 1579 nurse aides out of 2872 completed the survey, for a 55% response rate. In addition to clinical outcomes, this study examined the relationship between CNA PSC scores and staff turnover. The relationship between certain demographic variables, such as level of education, tenure as a CNA, and PSC scores was evaluated. The relationship between certain facility characteristics, such as profit status and bed occupancy was also assessed. An exploratory factor analysis of the original HSOPSC instrument was re-run for this nursing home CNA sample. Data were analyzed using Poisson regression and multilevel techniques; descriptive statistics were compiled for demographic data. Major findings from the regression analyses and combined GEE models suggest that certain factors, such as CNA turnover and LPN staffing may predict CNA PSC scores. CNA PSC scores were associated with rates of falls and restraint use, but were not associated with differences in pressure ulcer rates in this sample. Few associations for CNA PSC with individual subscales were identified. The exploratory factor analysis revealed some potential differences in how items and subscales factored in this nursing home CNA population. This dissertation represents an important step in the evaluation of CNA PSC in nursing homes and the relationship of PSC to safety outcomes. Future work on nursing home PSC and clinical and workforce outcomes is described.
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Libros sobre el tema "Safety outcome"

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Csizmadia, Emanuel. Antimalarial drugs: Costs, safety and efficacy. New York: Nova Biomedical Books, 2009.

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Emanuel, Csizmadia y Kalnoky Istvan, eds. Antimalarial drugs: Costs, safety, and efficacy. Hauppauge, NY: Nova Science, 2009.

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Purdy, Newhouse Robin y Poe Stephanie, eds. Measuring patient safety. Sudbury, Mass: Jones and Bartlett Publishers, 2005.

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Sherwood, Gwen. Quality and safety in nursing: A competency approach to improving outcomes. Chichester, West Sussex, UK: Wiley-Blackwell, 2012.

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McGillis, Hall Linda, ed. Quality work environments for nurse and patient safety. Sudbury, Mass: Jones and Bartlett Publishers, 2005.

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Society of American Gastrointestinal Endoscopic Surgeons, ed. The SAGES manual of quality, outcomes, and patient safety. New York: Springer, 2012.

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Finison, Karl S. Standardized reporting using CODES (Crash Outcome Data Evaluation System). [Washington, D.C.]: U.S. Dept. of Transportation, National Highway Traffic Safety Administration, 2000.

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Patient safety: The PROACT root cause analysis approach. Boca Raton: Taylor & Francis, 2008.

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Rayburn, William F. y Paul A. Gluck. Patient safety in obstetrics and gynecology: Improving outcomes, reducing risks. Philadelphia: Saunders, 2008.

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Donna, Farley y Rand Corporation, eds. Assessing patient safety practices and outcomes in the U.S. health care system. Santa Monica, CA: RAND, 2009.

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Capítulos de libros sobre el tema "Safety outcome"

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Stretton, Paul. "Continual Coaching: Moving from Outcome to Process". En Quantum Safety, 127–40. New York: Productivity Press, 2022. http://dx.doi.org/10.4324/9781003175742-11.

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Nasca, Brian J., Jonah J. Stulberg, Marylise Boutros y Jeongyoon Moon. "The Current State of Surgical Outcome Measurement". En The SAGES Manual of Quality, Outcomes and Patient Safety, 223–57. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-94610-4_13.

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Miller, Ted R. y David T. Levy. "Reducing Highway Crash Costs: The Cost-Outcome Analyses". En Transportation, Traffic Safety and Health — Man and Machine, 171–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57248-7_15.

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Lin, Li-An, Ed Whalen, Melvin Munsaka y William Wang. "Pragmatic Trials with Design Considerations for Cardiovascular Outcome Trials". En Quantitative Drug Safety and Benefit-Risk Evaluation, 215–32. Boca Raton: Chapman and Hall/CRC, 2021. http://dx.doi.org/10.1201/9780429488801-13.

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Assailly, Jean-Pascal. "Young People Drunk-Driving: Process and Outcome Evaluation of Preventive Actions". En Transportation, Traffic Safety and Health — Human Behavior, 297–326. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/978-3-642-57266-1_18.

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Day, Andrew y James Vess. "The importance of personal safety to therapeutic outcome in the prison setting". En Transforming environments and rehabilitation, 132–46. Abingdon, Oxon; New York, NY: Routledge, 2018. | Series: Issues in forensic psychology; 7: Routledge, 2017. http://dx.doi.org/10.4324/9781315660813-7.

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Brooks, Anthony L. y Eva Petersson Brooks. "Facilitators’ Intervention Variance and Outcome Influence When Using Video Games with Fibromyalgia Patients". En Digital Human Modeling and Applications in Health, Safety, Ergonomics, and Risk Management. Healthcare and Safety of the Environment and Transport, 163–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-39173-6_20.

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Thieme, Christoph A., Marilia A. Ramos, Even A. Holte, Stig O. Johnsen, Thor Myklebust y Øyvind Smogeli. "New Design Solutions and Procedures for Ensuring Meaningful Human Control and Interaction with Autonomy: Automated Ferries in Profile". En Autonomous Vessels in Maritime Affairs, 213–42. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24740-8_11.

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AbstractThis chapter summarizes the findings concerning the operation of automated ferries. First, a use-case on a planned passenger ferry in Norway is presented. Next, a gap analysis is carried out on the proposed solution against applicable rules. Finally, the outcome of the gap analysis is used as input for operational procedures, including decision criteria for a safety supervisor and the remote supervision center onshore and the information they need to make decisions. The results can be used when setting requirements for the infrastructure and human–machine interfaces for the safety supervisor and the remote supervision center. The outcome of this study is used in the AutoSafe project to further develop safety measures for automated passenger ferries. Additionally, gaps in the current regulations regarding the operation of automated passenger ferries are described
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Wipf, Heinz. "Safety Versus Security in Aviation". En The Coupling of Safety and Security, 29–41. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-47229-0_4.

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Abstract The two domains safety and security have traditionally been kept separated in aviation. While the first treats risks associated with aviation activities, the latter safeguards civil aviation against acts of unlawful interference. While national and international guidelines exist in addressing the installation of risk management for organizations having hazardous operations in aviation, an appropriate application of established assessment techniques, both quantitative and qualitative are crucial to both domains. For an incorrect hazard identification and the quantification of an adverse outcome may strongly affect both the level of protection and the investments required to reach it. The empirical example and data shown stem from safety risk assessments in HEMS (helicopter emergency medical service) flight operations. These flight operations use advanced instrument flight procedures in obstacle rich environments under low visibility conditions and are therefore a safety concern on the one hand. On the other hand, one analyzes security, whenever HEMS flights are operated in adverse weather conditions, having as a sole navigation source signals from a global navigation satellite constellation. A traditional safety risk assessment (Wipf in Aviation risk and safety management, Springer, p 108, 1) under these circumstances, considers only factors of human performance under technical failure conditions. A security analysis, however, should treat all forms of jamming, meaconing, and spoofing of the satellite signals and the adverse impact on the performance of the receiver to calculate a valid position. The chapter illustrates to which extent commonalities reign in both domains and where practices go separate ways.
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Robertsen, R., G. Sætren y P. Haukeberg. "Theoretical learning outcome of night driving. A comparison study of traditional real life training and simulator training". En Risk, Reliability and Safety: Innovating Theory and Practice, 1018–22. Taylor & Francis Group, 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, FL 33487-2742: CRC Press, 2016. http://dx.doi.org/10.1201/9781315374987-153.

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Actas de conferencias sobre el tema "Safety outcome"

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Nazeer, Aisha, Faisal Majeed, Audrey Lee y Yean Lim. "P231 Safety and outcome of colonoscopy in the nonagenarians". En Abstracts of the BSG Annual Meeting, 20–23 June 2022. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2022. http://dx.doi.org/10.1136/gutjnl-2022-bsg.285.

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Lyons, M. N. "Using data from simulation training in modelling emergency response outcome". En 3rd IET International Conference on System Safety 2008. IEE, 2008. http://dx.doi.org/10.1049/cp:20080698.

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Sharma, A., N. Barnes y BP Madden. "S39 Rigid bronchoscopy safety and outcome – a single centre retrospective analysis". En British Thoracic Society Winter Meeting, Wednesday 17 to Friday 19 February 2021, Programme and Abstracts. BMJ Publishing Group Ltd and British Thoracic Society, 2021. http://dx.doi.org/10.1136/thorax-2020-btsabstracts.44.

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Qadir, Abdul y Mohammad Muzammill. "PW 0391 Complicated tibial plateau fractures in young patients: functional outcome with dual plating via 2­incisiontechnique experience of two public sector hospitals of karachi pakistan". En Safety 2018 abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/injuryprevention-2018-safety.680.

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Al-ruwaisan, R., R. Bahmaid y N. Albanyan. "4CPS-044 Impact of clinical pharmacist-vancomycin monitoring on patient safety outcome". En 24th EAHP Congress, 27th–29th March 2019, Barcelona, Spain. British Medical Journal Publishing Group, 2019. http://dx.doi.org/10.1136/ejhpharm-2019-eahpconf.193.

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Lunia, Prajay, Unnati Desai y Jyotsna Joshi. "Ambulatory Chest Drainage: Assessment of Efficacy, Safety and Outcome in Pleural Diseases". En ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.pa735.

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Pinturier, Laurence Maryvonne, Ulf Einar Moltu y Steinar Sanni. "Biological Monitoring of Marine Waters for E & P Activities: Outcome of a 10 Years Strategic Research Program". En SPE International Health, Safety & Environment Conference. Society of Petroleum Engineers, 2006. http://dx.doi.org/10.2118/98610-ms.

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Alharbi, Rayan, Charne Miller y Virginia Lewis. "P5.009 Predictors of psychological and functional outcome following traffic injuries: a scoping review". En Virtual Pre-Conference Global Injury Prevention Showcase 2021 – Abstract Book. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/injuryprev-2021-safety.229.

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Sander, Willems, Labeau Pierre-Etienne, Maun Jean-Claude, Vergnol Arnaud y Sprooten Jonathan. "Probabilistic Transmission Expansion Planning: On the Effects of Outcome Variability on Decision-making". En Proceedings of the 29th European Safety and Reliability Conference (ESREL). Singapore: Research Publishing Services, 2019. http://dx.doi.org/10.3850/978-981-11-2724-3_0672-cd.

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Duffey, Romney B. y John W. Saull. "The Human Bathtub: Safety and Risk Predictions Including the Dynamic Probability of Operator Errors". En 14th International Conference on Nuclear Engineering. ASMEDC, 2006. http://dx.doi.org/10.1115/icone14-89476.

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Reactor safety and risk are dominated by the potential and major contribution for human error in the design, operation, control, management, regulation and maintenance of the plant, and hence to all accidents. Given the possibility of accidents and errors, now we need to determine the outcome (error) probability, or the chance of failure. Conventionally, reliability engineering is associated with the failure rate of components, or systems, or mechanisms, not of human beings in and interacting with a technological system. The probability of failure requires a prior knowledge of the total number of outcomes, which for any predictive purposes we do not know or have. Analysis of failure rates due to human error and the rate of learning allow a new determination of the dynamic human error rate in technological systems, consistent with and derived from the available world data. The basis for the analysis is the “learning hypothesis” that humans learn from experience, and consequently the accumulated experience defines the failure rate. A new “best” equation has been derived for the human error, outcome or failure rate, which allows for calculation and prediction of the probability of human error. We also provide comparisons to the empirical Weibull parameter fitting used in and by conventional reliability engineering and probabilistic safety analysis methods. These new analyses show that arbitrary Weibull fitting parameters and typical empirical hazard function techniques cannot be used to predict the dynamics of human errors and outcomes in the presence of learning. Comparisons of these new insights show agreement with human error data from the world’s commercial airlines, the two shuttle failures, and from nuclear plant operator actions and transient control behavior observed in transients in both plants and simulators. The results demonstrate that the human error probability (HEP) is dynamic, and that it may be predicted using the learning hypothesis and the minimum failure rate, and can be utilized for probabilistic risk analysis purposes.
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Informes sobre el tema "Safety outcome"

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Bendure, A. O. y S. A. Walker. Integrated environmental, health and safety management; The outcome of the `Necessary and Sufficient Process`. Office of Scientific and Technical Information (OSTI), mayo de 1996. http://dx.doi.org/10.2172/230622.

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ISODA, N. Zoonosis and food safety – improving collaboration between animal and public health professionals to achieve a better outcome. O.I.E (World Organisation for Animal Health), 2019. http://dx.doi.org/10.20506/tt.2988.

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Zhang, Yong. Efficacy and safety of corticosteroid therapy in patients with cardiac arrest: a meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, enero de 2023. http://dx.doi.org/10.37766/inplasy2023.1.0014.

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Review question / Objective: Our goal was to assess the effect of primary treatment outcome (overall survival rate at hospital discharge, rate of sustained ROSC) and secondary outcomes (favorable neurological outcomes at hospital discharge and adverse events including hyperglycemia, insulin infusion, hypernatremia, infection, gastrointestinal bleeding, new or changing antibiotics, paresis, renal failure). Information sources: Two researchers (Zhou FW and Liu C) independently searched the PubMed, Embase, The Cochrane Library, Web of Science and China National Knowledge Internet (CNKI) databases from inception to 11 October, 2022 by using medical subject headings (MeSH), Emtree, and text word with no language limitations.
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Msuha, Basil, Luitfred D. Kissoly y Arnold Kihaule. Design and implementation of Social Safety Nets in Tanzania: A protocol for a systematic review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, agosto de 2022. http://dx.doi.org/10.37766/inplasy2022.8.0074.

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Review question / Objective: This systematic review aims to assess the design and implementation features of social safety programs in Tanzania. To this end, the proposed systematic review will answer the following questions: i. What are the types of social safety net interventions that have been and/or are being implemented in Tanzania? and ii. What evidence of the design and implementation features of social safety net programs can be discerned in existing literature? These review questions are framed based on the population, intervention, comparison, and outcome (PICO) framework for preparing review questions. Condition being studied: Our factor of interest to be addressed by the systematic review are mainly two (A) core design features; and (B) implementation features of SSNs: The discussion on core design features will focus on: type of SSNs, main recipient, transfer value and frequency, coverage, duration of exposure and outcome. The implementation features will cover aspects such as: conditionality, targeting, payment mechanisms and governance, and implementation challenges.
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Qiu, Mei, Liang-Liang Ding y Hai-Rong Zhou. Comprehensive analysis of the safety of three new drug classes for type 2 diabetes: a meta-analysis of cardiovascular outcome trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, noviembre de 2020. http://dx.doi.org/10.37766/inplasy2020.11.0036.

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Verdam, Mathilde, Jae-Yung Kwon, Lara Russel, Véronique Sébille, Mirjam Sprangers y Rick Sawatzky. The impact of response shift on patient-reported outcome measures (PROMs): A systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, febrero de 2023. http://dx.doi.org/10.37766/inplasy2023.2.0024.

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Review question / Objective: Are the serum levels of estrogens (estrone, estradiol, estriol), gonadotropins (FSH, LH), or other hormones altered after intravaginal application of estriol for the treatment of genitourinary syndrome of menopause? Condition being studied: The aim of this review is to study whether the vaginal application of estriol has any effects on the serum levels of different sex hormones, mainly estriol, estradiol, and FSH, as those have been previously used as proxies for the safety of similar estrogenic products. Study designs to be included: Included: RCTs, controlled studies, head-to-head comparisons, systematic reviews, meta-analyses, quasi-experimental studies (intervention/no control).
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Fan, Yihua, Xiaoyin Zhao, Xiaoxu He y Huixin Chen. Efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis: A protocol of a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0153.

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Review question / Objective: To evaluate the efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis. Eligibility criteria: 1.1.1 Literature type Randomized controlled trials of treating AGA with Chinese herbal compound alone, whether blind or not, was limited to Chinese literature and English literature.1.1.2 SubjectsThe time of onset, gender, and age of patients diagnosed with acute gouty arthritis were not restricted.1.1.3 Intervention measures The treatment group was treated with traditional Chinese medicine compound, which could be proprietary Chinese medicine, self-made prescription or classic prescription, and the dosage form could be traditional decoction, granule or pill, while the control group was treated with non-steroidal anti-inflammatory painkillers, and the frequency, dosage and course of use were not limited.1.1.4 Outcome indicators(1) Main outcome measures: total response rate; (2) Secondary outcome indicators: visual analog scale (VAS), TCM syndrome score, blood uric acid, ESR, CRP, and incidence of adverse reactions.
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Fan, Yihua, Xiaoyin Zhao, Xiaoxu He y Huixin Chen. Efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis: A protocol of a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, abril de 2022. http://dx.doi.org/10.37766/inplasy2022.4.0153.

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Review question / Objective: To evaluate the efficacy and safety of Chinese herbal compound in the treatment of acute gouty arthritis. Eligibility criteria: 1.1.1 Literature type Randomized controlled trials of treating AGA with Chinese herbal compound alone, whether blind or not, was limited to Chinese literature and English literature.1.1.2 SubjectsThe time of onset, gender, and age of patients diagnosed with acute gouty arthritis were not restricted.1.1.3 Intervention measures The treatment group was treated with traditional Chinese medicine compound, which could be proprietary Chinese medicine, self-made prescription or classic prescription, and the dosage form could be traditional decoction, granule or pill, while the control group was treated with non-steroidal anti-inflammatory painkillers, and the frequency, dosage and course of use were not limited.1.1.4 Outcome indicators(1) Main outcome measures: total response rate; (2) Secondary outcome indicators: visual analog scale (VAS), TCM syndrome score, blood uric acid, ESR, CRP, and incidence of adverse reactions.
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Li, Shifu, Wengui Tao, Chudai Zeng, Langchao Yan y Fenghua Chen. The safety and efficacy of flow diverter versus conventional endovascular treatment in intracranial aneurysm: a meta-analysis of the real-world cohort studies over last ten years. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, octubre de 2021. http://dx.doi.org/10.37766/inplasy2021.10.0061.

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Review question / Objective: Did adult patients with intracranial aneurysms (patient population) who underwent flow diverter (FD, Intervention) have better clinical outcomes, higher rates of aneurysm occlusion, and lower rates of mortality and procedure related complications (outcomes) when compared with patients who received the conventional endovascular treatments (CEV, control) from January 2010 to December 2020? Eligibility criteria: The inclusion criteria are: 1. directly comparison of FD and conventional endovascular treatment, including coiling alone, stent alone, stent-assisted coiling, and balloon-assisted coiling; 2. patients ≥18 years with intracranial aneurysms; 3. detailed follow up angiographic and clinical outcomes; 4. the number of patients in two groups at least 10 patients. The exclusion criteria are:1. less than 10 participants in either group; 2. without the report of outcome variables; 3. studies primarily focus on children patients; 4. studies primarily focus on one interventional tool.
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Zhuo, Chuanjun, Hongjun Tian, Lina Wang, Xiangyang Gao, Li Ding y Ming Liu. Comparative safety of glucagon like peptide‑1 receptor agonists in patients with type 2 diabetes: a network meta-analysis of cardiovascular outcome trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, agosto de 2020. http://dx.doi.org/10.37766/inplasy2020.8.0122.

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