Tesis sobre el tema "Rythmes veille"
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WEIBEL, LAURENCE. "Effets de decalages du cycle veille-sommeil sur les rythmes biologiques chez l'homme". Université Louis Pasteur (Strasbourg) (1971-2008), 1996. http://www.theses.fr/1996STR13209.
Texto completoChapotot, Florian. "Régulation physiologique de la vigilance chez l'homme : relations entre les activités électroencéphalographiques et corticotrope au cours du sommeil et de la veille". Université Louis Pasteur (Strasbourg) (1971-2008), 2000. http://www.theses.fr/2000STR13214.
Texto completoSallanon, Marcelle. "Régulations hypothalamiques et hypophysaires du cycle veille-sommeil et leurs contrôles par les indolamines". Lyon 1, 1989. http://www.theses.fr/1989LYO19006.
Texto completoLéger, Damien. "Effets de la privation de lumiere sur les rythmes veille-sommeil de sujets non voyants". Paris 6, 2000. http://www.theses.fr/2000PA066283.
Texto completoDupont, Rocher Sandrine. "Effet de l'entrainement physique sur les aptitudes physiques et la rythmicité circadienne de la personne vieillissante". Caen, 2009. http://www.theses.fr/2009CAEN2022.
Texto completoThis work takes as a starting point the work centered on the degradation of the circadian rates/rhythms observed during ageing and of work showing that the physical drive has effects on the structure of the biological rhythms. The objective of this thesis was to study the effects of the practice of physical-activity on the circadian rythmicity like on the actimetric quality of the sleep in the elderly. In parallel, the analysis of a program of drive was carried out, because if it is unanimously allowed that to any age the participation in a program of drive can reduce the noxious effects of ageing. Obtaining physiological, metabolic, and functional adaptations requires the execution of exercises adapted in terms of intensity and volume. The first comparative study (actives/ sedentaries), characterized by the VO2max index) and the second proposing a program of 16 weeks drive multivarized on sedentary subjects of more than 60 years, highlighted an improvement of the rhythms studied for the active subjects physically, or consecutively following the program of drive More particularly, these results show that the amplitude of the temperature and more important and that the reflection actimetric of the sleep is more qualitative at the active people having a physical good condition, in comparison with sedentaries. They also highlight that it is completely possible by the means of one of multivariate drive to improve in parallel the force, the flexibility, the level of VO2max as well as the fat mass. This work confirms that the physical-activity can be regarded as a donor of time as well as the light, which opens prospects in terms for reconditioning for the biological clock. It also makes it possible to reconsider the programs of traditional drives and offers a possible solution to improve the general physical condition necessary for the maintenance of autonomy and quality of life
Martin, Tristan. "Etude de l'implication du système vestibulaire dans la synchronisation des rythmes biologiques". Caen, 2015. http://www.theses.fr/2015CAEN2010.
Texto completoThe aim was to study whether the vestibular system, which is stimulated in phase with the day-night alternance, is involved in circadian rhythms regulation in human and in animal. In rat, a chemical bilateral vestibular loss (bvl) caused a sudden and temporary disruption of circadian rhythms of body temperature and locomotor activity. In human, we have characterized circadian rhythms in patients suffering from an idiopathic bvl. Circadian rhythms were present in these patients but were desynchronized from their sleep/wake cycle. Sleep was also qualitatively disrupted and quantitatively short. We also aimed to explore the effect of an acute vestibular stimulation on re-entrainment of circadian rhythms after a 6h jet lag. Bvl rats were not influenced by the vestibular stimulation and have shown a modification of rhythmicity within a couple of day after jet lag. Conversely, this stimulation caused an entrainment of circadian rhythms in sham rats, which exhibited identical circadian rhythms before and during the period of stimulation after jet lag. So, vestibular system is not necessary to entrainment of circadian rhythms on a 24 h period. However, it could be related to the stability and precision of ld entrainment. Vestibular system should thus not be considered as a time cue which would act in an isolated manner on biological rhythms, but as a system which act in synergy with the visual one to enhance the synchronization on a 24 h period. This work demonstrates that the effect of vestibular inputs is strong enough to be used for rehabilitation in patients with sleep and chronobiological disorders
Gruau, Sandrine. "Modifications des rythmes circadiens chez la personne âgée par l'activité physique : évaluation de ces effets sur le rythme de la température, le rythme veille/sommeil et les performances diurnes en conduite automobile simulée". Caen, 2002. http://www.theses.fr/2002CAEN2073.
Texto completoMauvieux, Benoit. "Effets d’un entrainement physique et sportif régulier, chronique ou temporaire, sur les rythmes biologiques du travailleur de nuit". Caen, 2004. http://www.theses.fr/2004CAEN2063.
Texto completoXia, Ruohan. "Etude du rôle de la proteine kinase A et de l'ubiquitine protease USP8 dans l'horloge circadienne de la drosophile". Paris 11, 2008. http://www.theses.fr/2008PA112043.
Texto completoThe Drosophila circadian clock involves transcriptional loops and post-translational mechanisms that generate daily oscillations of the PERIOD (PER) and TIMELESS (TIM) proteins. My first project aims at understanding the circadian function of PKA in the Drosophila circadian clock. Mutants of the gene encoding the catalytic subunit of the cAMP-dependent protein kinase A (PKA) were shown to display altered behavioral rhythms but normal clock proteins oscillations in head extracts, suggesting that PKA acts downstream of the core clock mechanism. We have expressed a PKA dominant negative regulatory subunit in the main clock neurons that control activity rhythms in constant darkness (the ventral lateral neurons (LNv) that express the pigment-dispersing factor, PDF), and in the eye photoreceptors. We show that decreased PKA activity in the clock neurons leads to behavioral arrhythmicity, thus indicating that PKA activity is required within the clock neurons. Furthermore, PKA inhibition stops PER and TIM protein oscillations in the PDF-positive LNv but does not appear to affect them in the other clock neurons or in the compound eye. Our results indicate that PKA plays a major role in the control of clock protein oscillations in the main pacemaker neurons, the PDF-expressing LNv. This therefore suggests that clock mechanisms vary among the neuronal subsets of the Drosophila circadian network. My second project aims at characterizing the putative circadian function of the CG5798 gene, which encodes a putative protein that is similar to the mammalian ubiquitin-specific protease USP8. CG5798 (dUsp8) transcripts levels were shown to be circadian regulated in the drosophila head. Using anti-dUSP8 antibodies, we show that dUSP8 protein levels weakly oscillate with higher levels at night. Transgenic flies have been generated to target overexpression (dUSP8 cDNA) or knockdown (dUSP8 RNAi) of the gene in the clock neurons. Flies expressing these transgenes in all clock neurons do show locomotor activity defects but targeted expression of dUSP8 RNAi in the PDF-expressing LNv does not affect behavioral rhythmicity, nor PER oscillations in the LNv. This suggests that USP8 is involved in other clock neurons(cells)
Berge, Benoît. "La trypanosomose humaine africaine et expérimentale : modélisation stochastique de la veille et du sommeil et approches chronobiologiques". Saint-Etienne, 2005. http://www.theses.fr/2005STET4001.
Texto completoA stochastic model is used to study the sleep-wake organization while the disruption of the circadian and ultradian rhythms during Human African Trypanosomiasis (HAT) as well as in a rat experimental model is apprehended by classical chronobiological techniques. Currently we observe a reemergence of HAT and new therapeutic strategies have to be developed. Treatment of HAT depends on the severity (stage I or stage II) of the illness and medication for the second stage has potential harmful side effects. We aim through this work to bring in an additional tool for specifying as early as possible the stage of the illness. This is conducted in two complementary directions : (i) an application of a stochastic modeling and a search for the underlying temporal periods in human sleep process are used to characterize the stage of the illness ; (ii) using the same approaches, the results obtained for humans are validated by a rat experimental model in addition to an histological search for the parasite in brain tissues of the infested animal
Philip, Pierre. "Déterminants intrinsèques et extrinsèques de la somnolence diurne : à propos d'études sur la privation de sommeil". Bordeaux 2, 1997. http://www.theses.fr/1997BOR28478.
Texto completoCusumano, Paola. "Control of rest-activity rhythms by the morning and the evening oscillators in Drosophila melanogaster". Paris 11, 2008. http://www.theses.fr/2008PA112277.
Texto completoDrosophila melanogaster is crepuscular, showing most of its locomotor activity at dawn and dusk. These activity rhythms are controlled by a circadian clock that is located in the brain, and relies on about 70 clock neurons in each hemisphere. Two distinct oscillators control the bimodal activity profile in light-dark (LD) cycles: a subset of ventral Lateral Neurons (four s-LNvs, the LN-MO) that express the Pigment Dispersing Factor (PDF) neuropeptide control the morning anticipation, whereas a subset of three PDF-negative dorsal lateral neurons that express Cryptochrome (CRY) in addition to the 5th PDF-negative s-LNv, which constitute the LN-EO, is sufficient to generate evening anticipation. The brain clock perceives light through CRY and the visual system. We show that the LN-EO is able to drive behavioural rhythmicity under constant light conditions (LL), when CRY function is reduced, whereas the PDF-expressing cells do not. We thus conclude that light perceived by the visual system has opposite effects on the two oscillators: it activates the output of the LN-EO and inhibits the output of the PDF-positive LNs. We found that visual system-mediated entrainment of the LN-EO requires PDF to properly phase the evening activity, whereas CRY-mediated entrainment does not. Flies devoid of both CRY and PDF do not display any evening activity in LD conditions. Molecular analysis of the LN-EO indicated a reversed phase of PER cycling, suggesting that PDF interacts with the visual system inputs to set the molecular phase of the LN-EO. We conclude that flies thus integrate light and PDF information to better define their temporal niche
Girin, Baptiste. "Influence de la respiration sur les rythmes du cerveau chez le Rat : une étude électrophysiologique au cours des cycles veille / sommeil". Thesis, Lyon, 2020. http://www.theses.fr/2020LYSE1024.
Texto completoInter-area communication requires the different brain rhythms to be coordinated across areas. This coordination can be achieved by synchronizing electrophysiological rhythms. As others, we hypothesized respiratory rhythm could act as a central clock for cerebral rhythms coordination. If true, one can expect neuronal activity to be influenced by respiration in a large brain network. We tested that by recording respiration and neuronal activity in different brain areas in the freely-moving rat during different vigilance states. In agreement with recent publications, we observed that all structures could be modulated by breathing. We provided the additional observation that such a modulation varies according to the vigilance state, each state being associated with a specific respiratory regime. Particularly, we observed a large-scale synchronization of all recorded structures on the respiratory rhythm is only observable in the calm awake state, where the breathing has a low frequency (2Hz), with a relatively high air flow. At the same time, we also observe a modulation of the fast gamma rhythm (35-80 Hz) in all areas, only in the calm awake state. To determine whether this general respiratory synchronization was a consequence of the state itself or of the respiratory regime, we sought to uncorrelated the brain state of the respiratory regime. Animals were thus recorded while breathing a CO2-enriched air, where the respiratory characteristics (frequency and amplitude) are increased compared to the normal air condition. We observed the across-areas respiratory synchronization observed in quiet state can be extended, under CO2 condition, to other vigilance states including sleep states (REM and non-REM).We show that the coordination of the brain by breathing is related to the combined effect of the amplitude and duration of inspiration. Finally, we wanted to evaluate the respective share of air flows related to breathing and central breathing control on the brain's training by breathing. We uncorrelated the animal's breathing from the air flows in the nasal cavity through a double tracheotomy experiment in the anesthetized animal. The first results seem to show that the air flows circulating in the nasal cavity during successive breaths have a preponderant part in the entrainment of the brain. In conclusion, breathing can lead to a large cortical network via the activation of the olfactory system by the air flows circulating in the nasal cavity. The optimal breathing regime for this training is slow and deep breathing. This study is important to understand how relaxation and meditation methods work on the brain
Faradji-Prevautel, Hélène. "Etude des mécanismes responsables de la régulation des rythmes circadiens du sommeil ou de l'activité chez les souris mutantes de la souche ZRDCT-An". Lyon 1, 1988. http://www.theses.fr/1988LYO19010.
Texto completoChahboune, Halima. "Observation du cortex cérébral par résonance magnétique nucléaire au cours du cycle veille-sommeil du rat : développements méthodologiques, instrumentaux et monitorage des signaux physiologiques". Lyon 1, 2003. http://www.theses.fr/2003LYO10154.
Texto completoSimon, Tarek. "Impact du chronotype sur les paramètres du sommeil en fonction de l'horaire de travail". Doctoral thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/26002.
Texto completoLe présent mémoire vise à évaluer l’association entre le chronotype et les difficultés de sommeil en lien avec l’horaire de travail. À cette fin, 116 travailleurs du réseau de la santé de la ville de Québec ont complété le questionnaire de chronotype de Horne et Ostberg (MEQ; 1976) en plus de remplir quotidiennement un agenda du sommeil sur une période de 2 semaines. Les participants ont été comparés selon leur horaire de travail (travailleurs de jour n = 43; travailleurs de nuit n = 73) et selon leur chronotype (du matin n = 37; neutre n = 59; du soir n = 20) pour déterminer les effets indépendants et interactifs de ces variables sur la durée du sommeil durant la période de sommeil principale, la durée du sommeil sur une période de 24 heures et la somnolence après le travail. Tel que postulé initialement, les résultats indiquent que le chronotype et l’horaire de travail ont un effet sur la période de sommeil principale, mais pas sur le sommeil au cours de 24 heures, de sorte que les travailleurs de nuit ont une période de sommeil principale qui est significativement plus courte que celle des travailleurs de jour. De plus, le raccourcissement de la période de sommeil principale après le travail de nuit semble principalement observable chez les travailleurs avec un chronotype du matin ou un chronotype neutre, un patron de résultats qui concorde avec les connaissances actuelles sur le rythme circadien et qui corrobore plusieurs études antérieures. Le fait que tous les travailleurs ont obtenu une durée du sommeil équivalente sur une période de 24 heures suggère qu’il est possible de compenser pour une période de sommeil principale écourtée, en prenant des siestes. Ainsi, les résultats obtenus dans le présent mémoire mettent en évidence l’importance des siestes chez les travailleurs de nuit, surtout ceux et celles avec une prédisposition matinale. Enfin, l’absence de différence entre les groupes quant au niveau de somnolence après le travail suggère que la somnolence excessive n’est pas un problème qui se limite au travail de nuit.
Fontaine, Charlotte. "Contrôle de l'horloge biologique par stimulus lumineux artificiel : application pour l'adaptation des opérateurs au travail de nuit". Doctoral thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/25971.
Texto completoRochon, Paul. "Rythme de la vigilance et de la cognition". Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21782/document.
Texto completoThe topic of this thesis relates to the rhythm of vigilance and cognition. In the first part, we validate a subjective evaluation of sleep propensity by reference to MSLT (Multiple Sleep Latency Test). By factorial analysis, it is assumed that there are three main dimensional components of vigilance (ergic or behavioral, emotional, and cognitive). Then, the rhythms of these three dimensions are measured with the circadian variations of the core body temperature and during a modification of state of consciousness (hypnosis). There is a reliable self-evaluation of sleep propensity. The variation of core body temperature seems to be correlated with the rhythm of the ergic dimension and with the cognitive dimension of vigilance. During a modification of state of consciousness as hypnosis, behaviour dimension and emotional dimension of vigilance seem to change.In the second part, we focus on the process of cognition during different state of consciousness (sleep, wake, hypnosis). By using a Remember/Know memory test, we observe quality recall modification (verbal, imagery and emotional conditions) according to the states of consciousness of the subject. Moreover, we highlight that forgetfulness is not a deleted process of information, but depends on access to memory
Tolle, Virginie. "La ghreline, une nouvelle hormone gastrointestinale se liant au récepteur des GH sécrétagogues : du contrôle de la sécrétion de l'hormone de croissance (GH) à la régulation de la prise alimentaire et des rythmes veille/sommeil". Paris 6, 2002. http://www.theses.fr/2002PA066353.
Texto completoCalvel, Laurent. "L’influence des effets directs, non circadiens de la lumière et de la phototransduction mélanopsinergique sur l’humeur, la veille et le sommeil". Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ039/document.
Texto completoSleep regulations and mood disorders exert strong functional interactions, representing a major public health challenge. Light greatly influences physiology and behavior, including regulation of locomotion,sleep and mood. These non-visual effects are either, indirect through the phase shifting of circadian rhythms or direct. Our goal was to characterize the direct, non-circadian effects of light on behaviorand to assess the contribution of the different photoreceptors involved. To achieve this, melanopsin knockout mice were exposed to different luminance (<10 lux, 150 lux, 600 lux) without changing the phase of circadian rhythm. Our results indicate that light influences mood, locomotion and sleep, with< 10 lux leading to mood and sleep homeostasis alteration. These effects are primarily mediated by melanopsin-based phototransduction. If confirmed in humans, our observations will have applications for the clinical use of light as well as for societal lighting conditions
LARCHE, CHRISTOPHE. "Le rythme veille-sommeil et ses troubles chez l'enfant : a propos d'une enquete dans des classes primaires de cours moyen deuxieme annee de la ville de cholet". Nantes, 1994. http://www.theses.fr/1994NANT015M.
Texto completoMelone, Marie-Anne. "Diagnοstic and therapeutic strategies οf circadian and sleep/wake rhythm disοrders in at-risk pοpulatiοns". Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR023.
Texto completoSleep health guidelines advocate for 7 to 9 hours of nightly sleep for the general population, yet sleep debt persists, presenting significant health risks, including metabolic, cardiac, mental, and neurocognitive diseases. This widespread sleep debt is often attributed to the conflict between modern lifestyles—characterized by artificial lighting, shift work, and social obligations—and our innate circadian rhythms, leading to a condition known as circadian dysrhythmia. Circadian rhythms are the natural oscillations in physiological processes that are essential for aligning genetic, physiological, and behavioral patterns with solar time to anticipate changes in our environment. The misalignment of these rhythms is increasingly linked to various health disorders. Diagnosing circadian rhythms and sleep/wake disorders poses challenges, as part of its definition relies on subjective assessments and clinical evaluations of sleep quality. Moreover, sleep/wake timing or chronotype questionnaires, although validated, may not accurately reflect individual circadian clocks. While melatonin measurement is considered the gold standard, its practical implementation is difficult, making actigraphy and sleep logs more common tools for identifying circadian rhythms and sleep/wake disorders. This highlights the need for improved diagnostic methods. Potential therapeutic interventions could help improve circadian dysrhythmias related health outcomes. In this context, this manuscript delves into the prevalence, risk factors, and consequences of circadian rhythms and sleep/wake disorders, particularly focusing on at-risk populations like student-athletes and critically ill patients, where misaligned zeitgebers exacerbate health risks. This work includes three studies’ findings and one narrative review on circadian rhythm and sleep/wake disorders, their risk factors, consequences, and potential treatments in populations prioritizing performance (student-athletes) and recovery (critically ill patients)
Limoge-Lendais, Isabelle. "Effets de l'électrostimulation cérébrale transcutanée sur le rythme veille-sommeil et le comportement alimentaire chez le rat". Paris 5, 1993. http://www.theses.fr/1993PA05M115.
Texto completoSimard, Chantal. "Caractéristiques du rythme veille-sommeil et facteurs contribuant à un sommeil nocturne consolidé chez le nourrisson de 5 mois". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ53309.pdf.
Texto completoTirilly, Ghislaine. "Ajustement du rythme veille-sommeil et de la vigilance aux horaires fractionnés en mer : influence des facteurs circadiens et sociaux". Toulouse 2, 2002. http://www.theses.fr/2002TOU20038.
Texto completoThe present research examines the effects of fragmented work schedules on sleep/wake patterns and alertness at sea. This question is related to the general problem of adaptation of the sleep/wake cycle and alertness to atypical schedules. The study provides a comprehensive view on the effects of real crew activity and social organization on those variables. To assess the extent of the problem, two observational field studies were undertaken: 1) oceanographic crew members (scientists, technicians and officers) working on a 12h cycle (4-on/8-off watchkeeping) across 3 weeks; 2) fishermen working on a 3-4 hour cycle across 11 days. In both maritime environments, crew members rated their subjective alertness (VAS). Sleep logs were assessed for each crew member, and actigraphy data were collected from a representative sub-sample of each watch type. Observations were conducted throughout the oceanographic trip, and for two days at the beginning, the middle and the end of the trip on the fishing boat. In the oceanographic vessel, several strategies were observed depending on watch schedules and socializing at meal times. Sleep patterns were characterized by a biphasic distribution of sleep, and delay in sleep onset. Fishermen showed a quasi-polyphasic sleep (4 sleep episodes at least) imposed by fishing activities. Both operations showed a reduction in total duration of sleep in 24h. Despite the sleep fragmentation and reduction, the circadian fluctuations in alertness were maintained and an important decrease was observed in both operations. A pronounced dip in the afternoon indicates the presence of a 12h component of alertness. Results suggest that, even though sleep is fragmented, the circadian control of subjective alertness continues. Nevertheless, sustained physical activity and social influences play an important role on the level of alertness and the stabilization of circadian rhythmicity. From the results of this study, recommendations have been developed to reduce the potential impact of fragmented work/rest schedules on efficiency at sea
Touron-Riflart, Nathalie. "Rythme circadien de temperature corporelle au cours du cycle veille-sommeil chez l'homme : influence de l'heure et des stades de sommeil". Paris 6, 1988. http://www.theses.fr/1988PA066571.
Texto completoTouron-Riflart, Nathalie. "Rythme circadien de température corporelle au cours du cycle veille-sommeil chez l'homme influence de l'heure et des stades de sommeil /". Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb376189360.
Texto completoClodore, Martine. "La vigilance : evolution circadienne et horaires de sommeil, importance de la typologie matin/soir". Paris 6, 1988. http://www.theses.fr/1988PA066153.
Texto completoDi, Nisi Joseph. "Modifications de la frequence cardiaque et de la vasomotricite digitale provoquees par le bruit : differences interindividuelles au cours de la veille et du sommeil". Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13041.
Texto completoCabanas, Magali. "Modification des activités de réseaux in vivo chez un modèle murin de la maladie de Huntington". Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0345/document.
Texto completoHuntington’s disease (HD) is an inherited pathology that causes selective degeneration ofindirect striatal pathway neurons of the basal ganglia. In addition to the classic motor,cognitive and psychiatric symptoms, patients and mouse models of HD develop sleepdisorders, which can appear at as early as pre-symptomatic stage. Furthermore, in vivoelectrophysiological study of R6/1 transgenic mice revealed a unique and pathological βrhythm that appear at early symptomatic stage and which is mainly observed during sleep.The aim of this thesis work was to examine the link between changes in cerebral networkactivities, sleep disturbances and β rhythm, and to determine the contribution of theseabnormalities to the behavioral disturbances observed in R6/1 mice. Our neuroimaging study of the marker of neuronal activity c-Fos showed a hyperactivation of frontostriatal pathway at pre-symptomatic stage without any activity changes of the vulnerable indirect pathway neurons. Our pharmacogenetic study demonstrated that changes of striatal projection neuronal activity can modify sleep/wake behaviors, without inducing the pathological β rhythm. Finally, our pharmacological study established a link between orexinergic system dysfunction and β rhythm emergence in R6/1 mice. Our data, therefore, described further the natures of altered neural circuit activity associated with different disease stages, in particular pre-motor symptomatic period, and the importance of these alterations for sleep disturbances as well as β rhythm appearance in transgenic HD mice
Huynh, Christophe. "Rythme veille-sommeil et dimensions cliniques dans le trouble de personnalité limite à l’adolescence". Thèse, 2013. http://hdl.handle.net/1866/10205.
Texto completoThis dissertation examines sleep-wake patterns and their associations with emotional instability, aggressiveness, and impulsivity in adolescents with Borderline Personality Disorder (BPD). First, a literature review showed in BPD adults similar objective sleep disturbances, as assessed with polysomnography, to those observed in adult depression. Between 1980 and 2010, no study has examined sleep-wake patterns, none has recruited BPD adolescents, and many did not control depression as a confounding factor. Considering these limitations, it became relevant to conduct a study on sleep-wake patterns in euthymic adolescents with BPD. Having a developmental perspective in mind is crucial since adolescence presents many physiological, psychological and social characteristics. Second, a research protocol was set up at the Mood Disorders Clinic. Adolescents with BPD and without current depression were recruited. They wore for nine days or more (period covering two weekends) an actigraph, a non-invasive device assessing ecologically sleep-wake patterns. Because treatment dropout is highly prevalent in BPD adolescents, study feasibility was examined to determine the reasons promoting and those interfering with recruitment and data collection. Reflections on methodological aspects of this study allowed explaining the limits of this type of research protocol. Third, sleep-wake patterns in BPD adolescents (n=18) was characterised. They were compared to youth with Bipolar Disorder (n=6), a mental disorder sharing many common manifestations with BPD, and to adolescents without mental disorder (n=20). Results suggest that BPD adolescents spend more time awake during the rest interval than teenagers from the two other groups. Furthermore, BPD adolescents present higher interdaily variability for rising time and total sleep time than the other adolescents. They wake up an hour later, therefore sleeping one more hour, than adolescents without mental disorder on schedule-free days. Fourth, correlation analyses between actigraphy data and self-report questionnaire scores assessing emotional instability, aggressiveness, and impulsivity suggest that time spent awake during time in bed is associated with more daily physical aggressiveness in BPD adolescents. To summarise, this dissertation adds to the current scientific literature by exploring for the first time sleep-wake patterns and its associations with symptomatic manifestations of BPD in adolescents. From these results, it is highly recommended to assess and treat their sleep-wake disturbances during their therapeutic care.