Bibliografías temáticas / RNA Synthesis

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  2. Tesis
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Literatura académica sobre el tema "RNA Synthesis"

Autor: Grafiati
Publicado: 4 de junio de 2021
Última modificación: 25 de julio de 2025

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Artículos de revistas sobre el tema "RNA Synthesis"

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Cazenave, C., and O. C. Uhlenbeck. "RNA template-directed RNA synthesis by T7 RNA polymerase." Proceedings of the National Academy of Sciences 91, no. 15 (1994): 6972–76. http://dx.doi.org/10.1073/pnas.91.15.6972.

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Sivakumaran, K., and C. Cheng Kao. "Initiation of Genomic Plus-Strand RNA Synthesis from DNA and RNA Templates by a Viral RNA-Dependent RNA Polymerase." Journal of Virology 73, no. 8 (1999): 6415–23. http://dx.doi.org/10.1128/jvi.73.8.6415-6423.1999.

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ABSTRACT In contrast to the synthesis of minus-strand genomic and plus-strand subgenomic RNAs, the requirements for brome mosaic virus (BMV) genomic plus-strand RNA synthesis in vitro have not been previously reported. Therefore, little is known about the biochemical requirements for directing genomic plus-strand synthesis. Using DNA templates to characterize the requirements for RNA-dependent RNA polymerase template recognition, we found that initiation from the 3′ end of a template requires one nucleotide 3′ of the initiation nucleotide. The addition of a nontemplated nucleotide at the 3′ en
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Beerens, Nancy, Barbara Selisko, Stefano Ricagno, et al. "De Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA Polymerase." Journal of Virology 81, no. 16 (2007): 8384–95. http://dx.doi.org/10.1128/jvi.00564-07.

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ABSTRACT All plus-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that functions as the catalytic subunit of the viral replication/transcription complex, directing viral RNA synthesis in concert with other viral proteins and, sometimes, host proteins. RNA synthesis essentially can be initiated by two different mechanisms, de novo initiation and primer-dependent initiation. Most viral RdRps have been identified solely on the basis of comparative sequence analysis, and for many viruses the mechanism of initiation is unknown. In this study, using the family prototype equine arter
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Modahl, Lucy E., Thomas B. Macnaughton, Nongliao Zhu, Deborah L. Johnson, and Michael M. C. Lai. "RNA-Dependent Replication and Transcription of Hepatitis Delta Virus RNA Involve Distinct Cellular RNA Polymerases." Molecular and Cellular Biology 20, no. 16 (2000): 6030–39. http://dx.doi.org/10.1128/mcb.20.16.6030-6039.2000.

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ABSTRACT Cellular DNA-dependent RNA polymerase II (pol II) has been postulated to carry out RNA-dependent RNA replication and transcription of hepatitis delta virus (HDV) RNA, generating a full-length (1.7-kb) RNA genome and a subgenomic-length (0.8-kb) mRNA. However, the supporting evidence for this hypothesis was ambiguous because the previous experiments relied on DNA-templated transcription to initiate HDV RNA synthesis. Furthermore, there is no evidence that the same cellular enzyme is involved in the synthesis of both RNA species. In this study, we used a novel HDV RNA-based transfection
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Macnaughton, Thomas B., Stephanie T. Shi, Lucy E. Modahl, and Michael M. C. Lai. "Rolling Circle Replication of Hepatitis Delta Virus RNA Is Carried Out by Two Different Cellular RNA Polymerases." Journal of Virology 76, no. 8 (2002): 3920–27. http://dx.doi.org/10.1128/jvi.76.8.3920-3927.2002.

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ABSTRACT Hepatitis delta virus (HDV) contains a viroid-like circular RNA that is presumed to replicate via a rolling circle replication mechanism mediated by cellular RNA polymerases. However, the exact mechanism of rolling circle replication for HDV RNA and viroids is not clear. Using our recently described cDNA-free transfection system (L. E. Modahl and M. M. Lai, J. Virol. 72:5449-5456, 1998), we have succeeded in detecting HDV RNA replication by metabolic labeling with [32P]orthophosphate in vivo and obtained direct evidence that HDV RNA replication generates high-molecular-weight multimer
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Röthlisberger, Pascal, Christian Berk, and Jonathan Hall. "RNA Chemistry for RNA Biology." CHIMIA International Journal for Chemistry 73, no. 5 (2019): 368–73. http://dx.doi.org/10.2533/chimia.2019.368.

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Advances in the chemical synthesis of RNA have opened new possibilities to address current questions in RNA biology. Access to site-specifically modified oligoribonucleotides is often a pre-requisite for RNA chemical-biology projects. Driven by the enormous research efforts for development of oligonucleotide therapeutics, a wide range of chemical modifications have been developed to modulate the intrinsic properties of nucleic acids in order to fit their use as therapeutics or research tools. The RNA synthesis platform, supported by the NCCR RNA & Disease, aims to provide access to a large
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ZACHLEDER, V., and I. ŠETLÍK. "Distinct controls of DNA replication and of nuclear division in the cell cycles of the chlorococcal alga Scenedesmus quadricauda." Journal of Cell Science 91, no. 4 (1988): 531–39. http://dx.doi.org/10.1242/jcs.91.4.531.

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In the course of the cell cycle of Scenedesmus quadricauda, the syntheses of RNA and total protein occur in steps. Each step represents an approximate doubling of the preceding amount of RNA or protein per cell. The increase in protein content per cell runs parallel to, but with a constant delay behind, the corresponding RNA steps. When protein synthesis is suppressed (e.g. by maintaining the cells in the dark) after an RNA synthesis step has already occurred the cells double their DNA content, but no corresponding nuclear division occurs and uninuclear daughter cells with double the amount of
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Doudna, Jennifer A., and Jack W. Szostak. "RNA-catalysed synthesis of complementary-strand RNA." Nature 339, no. 6225 (1989): 519–22. http://dx.doi.org/10.1038/339519a0.

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Illangasekare, M., G. Sanchez, T. Nickles, and M. Yarus. "Aminoacyl-RNA synthesis catalyzed by an RNA." Science 267, no. 5198 (1995): 643–47. http://dx.doi.org/10.1126/science.7530860.

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Doudna, J. A., and J. W. Szostak. "RNA-catalysed synthesis of complementary strand RNA." Trends in Genetics 5 (1989): 323. http://dx.doi.org/10.1016/0168-9525(89)90125-x.

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Tesis sobre el tema "RNA Synthesis"

1

Peters, D. W. "RNA synthesis in Candida albicans." Thesis, University of Warwick, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373051.

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Fritz, Sarah E. "Molecular basis of the DExH-box RNA helicase RNA helicase A (RHA/DHX9) in eukaryotic protein synthesis." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437413252.

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Lackey, Jeremy. "New methods for the synthesis of RNA, novel RNA pro-drugs and RNA microarrays." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92290.

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The demand for synthetic oligonucleotides has grown exponentially over the past decades as genome sequencing, functional genomics, polymerase chain reaction (PCR)-based detection methods, and gene silencing via RNA interference (RNAi) consume enormous numbers of DNA and RNA oligonucleotides. Although various RNA synthesis chemistries now allow oligoribonucleotides to be produced routinely, the higher complexity and cost of RNA (over DNA) has somewhat limited its availability.<br>A major goal of this thesis work was aimed at finding ribonucleoside synthons that potentially benefit two critical
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Johnston, Julie Catherine. "In vitro translation of cucumber necrosis virus RNA." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/28969.

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The in vitro translation products directed by cucumber necrosis virus (CNV) RNA were analyzed in both rabbit reticulocyte lysate and wheat germ extract cell-free translation systems. In rabbit reticulocyte lysates, one major protein of ca. 33 Mr was produced. In wheat germ extracts, four proteins of ca. 41, 33, 21 and 20 Mr were produced. Hybrid-arrested translation (HART) studies using synthetic CNV antisense RNA corresponding to the entire CNV genome demonstrated that the four major proteins synthesized from CNV virion RNA in wheat germ extracts are virus-specific translation products. The g
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Attwater, James. "Ice as a medium for RNA-catalysed RNA synthesis and evolution." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/246525.

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A critical event in the origin of life is thought to have been the emergence of a molecule capable of self-replication and evolution. According to the RNA World hypothesis, this could have been an RNA polymerase ribozyme capable of generating copies of itself from simple nucleotide precursors. In vitro evolution experiments have provided modern examples of such ribozymes, such as the R18 RNA polymerase ribozyme, exhibiting basic levels of this crucial catalytic activity; R18’s activity, however, falls far short of that required of an RNA replicase, leaving unanswered the question of whether RN
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Collis, Alana E. C. "The synthesis of vinylphosphonate-linked RNA." Thesis, University of Nottingham, 2008. http://eprints.nottingham.ac.uk/10541/.

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An introductory chapter discusses the steric block, RNase H and RNA interference antisense mechanisms and the application of antisense nucleic acids as therapeutic agents. Examples of existing chemical modifications of the sugar and backbone regions of nucleic acids are given, followed by the introduction of the vinylphosphonate modification. The vinylphosphonate has previously been examined in DNA and has been synthesised by either Pd(0) catalysed cross-coupling of an H-phosphonate with a vinyl bromide, or by the cross-metathesis of a vinylphosphonate with a terminal olefin. This thesis detai
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Liu, Qi. "Synthesis of small molecules targeting RNA /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3142456.

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D'Abramo, Claudia M. "Biochemical characterization of the BVDV RNA-dependent RNA polymerase during initiation and elongation of RNA synthesis." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111870.

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The RNA-dependent RNA polymerase (RdRp) of viruses belonging to the Flaviviridae family, including the hepatitis C virus (HCV) and bovine viral diarrhea virus (BVDV) is critical for viral replication. The major goal of this PhD study was to biochemically characterize the role of the polymerase during initiation and elongation of RNA synthesis, utilizing the BVDV RdRp as a model system. We showed that the BVDV polymerase efficiently incorporates chain-terminating nucleoside analogues, which ultimately arrest RNA synthesis. The incorporated chain-terminators, however, can be removed from the pri
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Repass, John F. "Studies of murine coronavirus cis-acting RNA elements that affect RNA synthesis /." Digital version accessible at:, 2000. http://wwwlib.umi.com/cr/utexas/main.

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Gilea, Manuela Aurora. "DNA and RNA synthesis in ionic liquids." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485198.

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The solid-phase synthesis of oligonucleotide derivatives such as phosphorothioates and phosphoroselenoates was investigated. Some ionic liquids containing the trlbexyl(tetradecyl)phosphonium cation and various anions proved to be very effective in dissolving the chalcogens (sulfur and , selenium) and to prepare oligonucleoside chalcogenophosphates. The suitability ofionic liquid-based chalcogen-transfer mixtures for the synthesis of oligonucleoside chalcogenophosphates on solid-phase was evaluated and subsequently the structure-activity relationship studied in detail. The compatibility of ioni
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Libros sobre el tema "RNA Synthesis"

1

Peters, David William. RNA synthesis in 'Candida albicans'. typescript, 1985.

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L, Hatfield Dolph, Lee Byeong J, and Pirtle Robert M, eds. Transfer RNA in protein synthesis. CRC Press, 1992.

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James, Dahlberg, and Abelson John, eds. RNA processing. Academic, 1989.

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Conn, Graeme L., ed. Recombinant and In Vitro RNA Synthesis. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-113-4.

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1953-, Krieg Paul A., ed. A laboratory guide to RNA: Isolation, analysis, and synthesis. Wiley-Liss, 1996.

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A, Narang Saran, ed. Synthesis and applications of DNA and RNA. Academic Press, 1987.

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Johnson, Moira A. Kinetics of RNA synthesis in rotavirus infected cells. typescript, 1988.

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Lynne, Maquat, ed. Nonsense-mediated mRNA decay. Landes Bioscience, 2006.

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service), ScienceDirect (Online, ed. RNA turnover in bacteria, archaea and organelles. Academic Press/Elsevier, 2008.

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Arnstein, H. R. V. Protein biosynthesis. IRL Press at Oxford University Press, 1992.

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Capítulos de libros sobre el tema "RNA Synthesis"

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Beckert, Bertrand, and Benoît Masquida. "Synthesis of RNA by In Vitro Transcription." In RNA. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-59745-248-9_3.

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Johnson, Kyle L., and Peter Sarnow. "Viral RNA Synthesis." In Human Enterovirus Infections. ASM Press, 2014. http://dx.doi.org/10.1128/9781555818326.ch4.

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van den Born, Erwin, and Eric J. Snijder. "RNA Signals Regulating Nidovirus RNA Synthesis." In Nidoviruses. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815790.ch8.

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Engels, Joachim W., Dalibor Odadzic, Romualdas Smicius, and Jens Haas. "Chemical Synthesis of 2′-O-Alkylated siRNAs." In RNA Interference. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-588-0_10.

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Frei, Julia, Natalia T. Jarzebska, Mark Mellett, Thomas M. Kündig, Steve Pascolo, and Andreas M. Reichmuth. "Design and Synthesis of Circular RNA Expression Vectors." In RNA Vaccines. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3770-8_9.

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Snijder, Eric J. "Arterivirus RNA Synthesis Dissected." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1325-4_39.

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Höbartner, Claudia. "Chemical Synthesis of RNA." In Alternative pre-mRNA Splicing. Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527636778.ch14.

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Huq, Tamanna Binte, and Juan L. Vivero-Escoto. "Synthesis of Mesoporous Silica Nanoparticles for the Delivery of Nucleic Acid Nanostructures." In RNA Nanostructures. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3417-2_13.

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Sproat, Brian S. "Chemical RNA Synthesis, Purification, and Analysis." In Handbook of RNA Biochemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527647064.ch7.

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Gößringer, Markus, Dominik Helmecke, Karen Köhler, et al. "Enzymatic RNA Synthesis Using Bacteriophage T7 RNA Polymerase." In Handbook of RNA Biochemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527647064.ch1.

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Actas de conferencias sobre el tema "RNA Synthesis"

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Mehta, Richa, Azizbek Khurramov, Vinay Kumar Deolia, M. Vamsikrishna, Haider Alabdeli, and R. Gunasundari. "Beam Synthesis in O-RAN 5G: Operational Considerations." In 2024 International Conference on Communication, Computing and Energy Efficient Technologies (I3CEET). IEEE, 2024. https://doi.org/10.1109/i3ceet61722.2024.10993633.

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Voloshin, A. A., E. A. Voloshin, A. I. Kovalenko, et al. "Algorithm of Automatic Synthesis of Optimal Solutions for Power Systems based on the Method of Dynamic Programming." In 2024 7th International Youth Scientific and Technical Conference on Relay Protection and Automation (RPA). IEEE, 2024. https://doi.org/10.1109/rpa65165.2024.10932888.

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Gao, Qi, Yao Li, Yukun DU, Jiang Jiang, and Haiyue Yu. "RDA-IC: a data synthesis approach for enhancing network performance in image classification tasks." In International Conference on Advances in Computer Vision Research and Applications, edited by Zhonghong Ou and Hui Liu. SPIE, 2025. https://doi.org/10.1117/12.3068854.

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Obeyesekere, Nihal, and Thusitha Wickramarachchi. "Transition from Combinatorial Chemistry to Present Day Robotics in Product Development for Oil Field Chemicals." In MECC 2023. AMPP, 2023. https://doi.org/10.5006/mecc2023-20245.

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Abstract In this paper, the slow evolution of combinatorial chemistry from its dawn in 1980’s to today’s oil field product development is discussed. Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a vast number of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. This phenomenon was first invented by Arpad Furka (Lorand University, Budapest) in 1982. He described the principle of it, the combinatorial synthesis and a deconvolution proc
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Kozlov, I. B., O. A. Gerasimov, O. Y. Domasheva, L. G. Bushina, and D. M. Fedoseeva. "PREPARATION AND APPLICATION OF SYNTHETIC RNA OLIGONUCLEOTIDE WITH 5’-TERMINAL PHOSPHATE." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-243.

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Technologies for creating genotherapeutic drugs using synthetic 5’-phosphorylated RNA oligonucleotides are being actively developed. The synthesis of these oligonucleotides is complicated by the methods selection for post-synthetic purification using HPLC. We propose combination of HPLC methods for efficient purification of the target product. The structure of the obtained 5’-phosphorylated RNA oligonucleotides was confirmed by LC-MS.
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Bakhno, I. A. "DESIGN AND SYNTHESIS OF MODIFIED RNAS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-294.

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RNA is a universal tool, it is involved in many cellular processes. Understanding the mechanisms of these processes is necessary not only to understand the fundamental principles of the structure of a living cell, but also to create drugs. In this regard, tools are required to create modified RNA analogs to study these processes.
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Smirnova, O. S., and I. D. Konstantinova. "CHEMO-ENZYMATIC SYNTHESIS OF NEW RIBAVIRIN ANALOGS." In OpenBio-2023. ИПЦ НГУ, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-51.

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Wachowius, Falk, Giuseppe Sicoli, Marina Bennati, and Claudia Höbartner. "Synthesis of spin-labeled RNA and probing of RNA secondary structures by pulsed EPR spectroscopy." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112336.

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Akama, Satoru, Masayuki Yamamura, and Takanori Kigawa. "Multi-Objective Robust Optimization for In Vitro RNA Synthesis." In Computational Intelligence and Bioinformatics / Modelling, Simulation, and Identification. ACTAPRESS, 2012. http://dx.doi.org/10.2316/p.2012.753-017.

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Akama, Satoru, Masayuki Yamamura, and Takanori Kigawa. "Multi-Objective Robust Optimization for In Vitro RNA Synthesis." In Computational Intelligence and Bioinformatics / Modelling, Simulation, and Identification. ACTAPRESS, 2011. http://dx.doi.org/10.2316/p.2011.753-017.

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Informes sobre el tema "RNA Synthesis"

1

Soell, D. [The first steps of chlorophyll synthesis: RNA involvement and regulation]. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/6528189.

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Nilsson, Emil. Synthesis of Sulfamoyl??Aminoacyl Adenylate Analogs for use in Protein?RNA Structure Determination. Portland State University Library, 2013. http://dx.doi.org/10.15760/honors.28.

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Walker, Richard T. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. Defense Technical Information Center, 1989. http://dx.doi.org/10.21236/ada229411.

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Stern, David, and Gadi Schuster. Manipulating Chloroplast Gene Expression: A Genetic and Mechanistic Analysis of Processes that Control RNA Stability. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7586541.bard.

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New potential for engineering chloroplasts to express novel traits has stimulated research into relevant techniques and genetic processes, including plastid transformation and gene regulation. This BARD-funded research dealt with the mechanisms that influence chloroplast RNA accumulation, and thus gene expression. Previous work on cpRNA catabolism has elucidated a pathway initiated by endonucleolytic cleavage, followed by polyadenylation and exonucleolytic degradation. A major player in this process is the nucleus-encoded exoribo-nuclease/polymerase polynucleotide phosphorylase (PNPase). Bioch
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Soell, D. [The first steps of chlorophyll synthesis: RNA involvement and regulation]. Progress report, January 1990--June 1992. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/10158546.

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Schuster, Gadi, and David Stern. Integration of phosphorus and chloroplast mRNA metabolism through regulated ribonucleases. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7695859.bard.

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New potential for engineering chloroplasts to express novel traits has stimulated research into relevant techniques and genetic processes, including plastid transformation and gene regulation. This proposal continued our long time BARD-funded collaboration research into mechanisms that influence chloroplast RNA accumulation, and thus gene expression. Previous work on cpRNA catabolism has elucidated a pathway initiated by endonucleolytic cleavage, followed by polyadenylation and exonucleolytic degradation. A major player in this process is the nucleus-encoded exoribonuclease/polymerasepolynucle
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Sionov, Edward, Nancy Keller, and Shiri Barad-Kotler. Mechanisms governing the global regulation of mycotoxin production and pathogenicity by Penicillium expansum in postharvest fruits. United States Department of Agriculture, 2017. http://dx.doi.org/10.32747/2017.7604292.bard.

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The original objectives of the study, as defined in the approved proposal, are: To characterize the relationship of CreA and LaeA in regulation of P T production To understand how PacC modulates P. expansumpathogenicity on apples To examine if other secondary metabolites are involved in virulence or P. expansumfitness To identify the signaling pathways leading to PAT synthesis Penicilliumexpansum, the causal agent of blue mould rot, is a critical health concern because of the production of the mycotoxinpatulin (PAT) in colonized apple fruit tissue. Although PAT is produced by many Penicilliums
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Wang, X. F., and M. Schuldiner. Systems biology approaches to dissect virus-host interactions to develop crops with broad-spectrum virus resistance. United States-Israel Binational Agricultural Research and Development Fund, 2020. http://dx.doi.org/10.32747/2020.8134163.bard.

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More than 60% of plant viruses are positive-strand RNA viruses that cause billion-dollar losses annually and pose a major threat to stable agricultural production, including cucumber mosaic virus (CMV) that infects numerous vegetables and ornamental trees. A highly conserved feature among these viruses is that they form viral replication complexes (VRCs) to multiply their genomes by hijacking host proteins and remodeling host intracellular membranes. As a conserved and indispensable process, VRC assembly also represents an excellent target for the development of antiviral strategies that can b
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Loebenstein, Gad, William Dawson, and Abed Gera. Association of the IVR Gene with Virus Localization and Resistance. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604922.bard.

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We have reported that localization of TMV in tobacco cultivars with the N gene, is associated with a 23 K protein (IVR) that inhibited replication of several plant viruses. This protein was also found in induced resistant tissue of Nicotiana glutinosa x Nicotiana debneyi. During the present grant we found that TMV production is enhanced in protoplasts and plants of local lesion responding tobacco cultivars exposed to 35oC, parallel to an almost complete suppression of the production of IVR. We also found that IVR is associated with resistance mechanisms in pepper cultivars. We succeeded to clo
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Lapidot, Moshe, and Vitaly Citovsky. molecular mechanism for the Tomato yellow leaf curl virus resistance at the ty-5 locus. United States Department of Agriculture, 2016. http://dx.doi.org/10.32747/2016.7604274.bard.

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Tomato yellow leaf curl virus (TYLCV) is a major pathogen of tomato that causes extensive crop loss worldwide, including the US and Israel. Genetic resistance in the host plant is considered highly effective in the defense against viral infection in the field. Thus, the best way to reduce yield losses due to TYLCV is by breeding tomatoes resistant or tolerant to the virus. To date, only six major TYLCV-resistance loci, termed Ty-1 to Ty-6, have been characterized and mapped to the tomato genome. Among tomato TYLCV-resistant lines containing these loci, we have identified a major recessive quan
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