Literatura académica sobre el tema "Régulation ciblée de la transcription"
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Artículos de revistas sobre el tema "Régulation ciblée de la transcription"
Furlan, Alessandro, Florence Agbazahou, Mélanie Henry, Mariano Gonzalez-Pisfil, Corentin Le Nézet, Dorian Champelovier, Marie Fournier, Bernard Vandenbunder, Gabriel Bidaux y Laurent Héliot. "P-TEFb et Brd4". médecine/sciences 34, n.º 8-9 (agosto de 2018): 685–92. http://dx.doi.org/10.1051/medsci/20183408015.
Texto completoPapai, Gabor y Patrick Schultz. "Régulation de la transcription par le coactivateur TFIID". médecine/sciences 26, n.º 12 (diciembre de 2010): 1018–19. http://dx.doi.org/10.1051/medsci/201026121018.
Texto completoLEROUX, C. y G. TOSSER-KLOPP. "La fonction du gène : les grandes étapes de l’utilisation de l’information génétique". INRAE Productions Animales 13, HS (22 de octubre de 2000): 21–28. http://dx.doi.org/10.20870/productions-animales.2000.13.hs.3807.
Texto completoDreyfus, JC. "Une mutation de l'ADN mitochondrial altère la régulation de sa transcription". médecine/sciences 7, n.º 7 (1991): 744. http://dx.doi.org/10.4267/10608/4449.
Texto completoPeille, A. L., A. Kauffmann, P. Largarde, V. Le Morvan, J. M. Coindre, F. Chibon y L. Bresson-Bépoldin. "R73: Régulation épigénétique du facteur de transcription ZAC dans les sarcomes". Bulletin du Cancer 97, n.º 4 (octubre de 2010): S43. http://dx.doi.org/10.1016/s0007-4551(15)30990-5.
Texto completoKahn, A. "Régulation de l'élongation de la transcription par le produit du gène VHL." médecine/sciences 11, n.º 11 (1995): 1603. http://dx.doi.org/10.4267/10608/2354.
Texto completoBatail, J. M. "Applications des techniques de neurofeedback dans la dépression". European Psychiatry 29, S3 (noviembre de 2014): 561–62. http://dx.doi.org/10.1016/j.eurpsy.2014.09.383.
Texto completoReboud-Ravaux, Michèle. "Dégradation induite des protéines par des molécules PROTAC et stratégies apparentées : développements à visée thérapeutique". Biologie Aujourd’hui 215, n.º 1-2 (2021): 25–43. http://dx.doi.org/10.1051/jbio/2021007.
Texto completoHOCQUETTE, J. F., H. BOUDRA, I. CASSAR-MALEK, C. LEROUX, I. PICARD, I. SAVARY-AUZELOUX, L. BERNARD et al. "Perspectives offertes par les approches en « omique » pour l’amélioration de la durabilité de l’élevage des herbivores". INRAE Productions Animales 22, n.º 5 (9 de diciembre de 2009): 385–96. http://dx.doi.org/10.20870/productions-animales.2009.22.5.3363.
Texto completoJacquet, Marie-Elisabeth y Goulven Kérien. "Enregistrer pour policer. Usages du registre et travail de bureau à la Lieutenance générale de police de Paris, 1730-1760". Revue d’histoire moderne & contemporaine 70-4, n.º 4 (31 de enero de 2024): 68–93. http://dx.doi.org/10.3917/rhmc.704.0070.
Texto completoTesis sobre el tema "Régulation ciblée de la transcription"
Mateescu, Bogdan. "Ciblage et régulation du facteur HP1 sur la chromatine". Paris 6, 2006. http://www.theses.fr/2006PA066203.
Texto completoBerodes, Maëlle. "Étude de l'importance de la phosphorylation sur l'activité transcriptionnelle du facteur de transcription GATA4 sur certains promoteurs cibles". Master's thesis, Université Laval, 2012. http://hdl.handle.net/20.500.11794/23448.
Texto completoLagha, Mounia. "Régulation du destin musculaire chez l'embryon de souris : les cibles de Pax3". Paris 7, 2008. http://www.theses.fr/2008PA077156.
Texto completoIn the mouse embryo, Pax3, which encodes a paired and homeodomain transcription factor, regulates the entry of muscle progenitor cells into the myogenic program and ensures their survival. In order to identify Pax3 targets in vivo in the myogenic context, we decided to focus on a subpopulation of Pax3+ cells, namely the muscle progenitors that migrate to the forelimb bud, which, at El0. 5, are not yet differentiated. We have used the Pax3GFP/+ allele to directly isolate a pure population of muscle progenitor cells by FACS sorting and analyzed their transcriptome by comparing Pax3GFP/+ to Pax3PAX3~FKHR/GFP cells where Pax3 targets genes are up-regulated. This screen led to the identification of 200 putative Pax3 target genes, 3 of which have been validated and further analysed. First, we have shown that the FGF signaling pathway is regulated by Pax3, notably through the direct activation of the gene encoding the Fgfr4 receptor and the intracellular inhibitor Sproutyl. We propose that Pax3 orchestrates the effects of the FGF signaling pathway to modulate the balance between a progenitor state and a differentiated state. Second, we establish that Pax3 and Foxc2 repress each other through a negative feedback loop,/with important consequences for myogenesis when this loop is perturbed. We propose that this equilibrium is required for cell fate choices in the dermomyotome. Third, the gene encoding the transmembrane protein Itm2a is directly regulated by Pax3 and its function during development has been studied by generating an Itm2a conditional allele, with potentially interesting results on somite integrity in the mutant embryos
Steunou, Anne-Lise. "Régulation de l'expression génique dans les mélanomes : implication des facteurs de transcription N Oct-3 et HIF". Toulouse 3, 2010. http://www.theses.fr/2010TOU30207.
Texto completoN Oct-3 (Brn-2 / POU3F2) is a master gene of melanoma proliferation. However, the molecular mechanisms associated with N Oct-3 induced melanoma proliferation are still not well understood. In collaboration with Dr L. Larue’s team at Marie Curie Institute in Orsay, I have demonstrated the role of this protein and particularly the phosphorylation of its DNA binding domain on the proliferation in melanocyte lineage proliferation and elucidated the molecular mechanisms associated with this process. Moreover, in collaboration with Dr I. Davidson’s team from the Institute of Genetics and Molecular and Cellular Biology in Illkirch, I have participated to the exhaustive analysis of N Oct-3 target genes in the 501-mel melanoma cell line. Furthermore, during my Ph. D. , I have also deal with transcription factors induced by hypoxia known as HIF (Hypoxia Inducible Factor) proteins. These proteins play a crucial role in angiogenesis and are involved in numerous pathologies as cancers and in particular melanomas. In order to characterize transcriptional complexes involving HIF-2 protein, I used a proteomic approach to identify nuclear protein partners of HIF-2 in melanomas. Our data revealed new interesting partners of HIF-2 protein like the transcription factors MITF and SOX10, two factors demonstrated as essential regulators of gene expression in melanomas, as well as Béta-catenin, a central protein of the Wnt/Béta-catenin pathway deregulated in more than 30% of melanomas
Devidal, Audrey. "Mécanismes et fonctions du ciblage centrométrique de NF-E2p18/MafK, sous-unité du facteur transcriptionnel érythroide NF-E2". Paris 7, 2005. http://www.theses.fr/2005PA077133.
Texto completoYi, Jia. "The Role of Convergent Transcription in Regulating Alternative Splicing : Targeted Epigenetic Modification via Repurposed CRISPR/Cas9 System and Its Impact on Alternative Splicing Modulation". Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS382.
Texto completoAlternative splicing of precursor RNA is a co-transcriptional process that affects the vast majority of human genes and contributes to protein diversity. Dysregulation of such process is implicated in various diseases, including tumorigenesis. However, the mechanisms regulating these processes were still to be characterized. In this study, we showed that perturbations of alternative splicing correlated with dysregulations of convergent transcription and DNA methylation. Convergent transcription could be generated between pairs of neighboring genes in opposite orientation, or between intragenic enhancers and their host gene. CENPO and ADCY3 was identified as a convergent transcription gene pair. We found, in a tumor progression model of breast cancer, that the splicing change of the ADCY3 variant exon22 correlated with an increase of its transcription that went against that of CENPO. By using targeted transcription repression system CRISPRi, we demonstrated that downregulating the transcription of CENPO could not reverse the alternative splicing alteration of ADCY3 in cancer cells (DCIS). An active intragenic enhancer was identified in the intron16 of CD44, at the downstream of its alternative exons. By using targeted transcription activation system CRISPRa, we showed that upregulating the transcription of CD44 could not alter the alternative splicing of CD44 in DCIS cells. These results suggest that convergent transcription modulation through changes of promoter activity does not alter the alternative splicing of ADCY3 and CD44 in DCIS cells. However, through replacing the intragenic enhancer by an inducible promoter, we found that intragenic transcription activation increased the inclusion level of several alternative exons of CD44 in HCT116 cells. This result suggested that local convergent transcription could have a direct impact on the alternative splicing of CD44. Furthermore, by using targeted DNA methylation system CRISPR/dCas9-DNMT3b, we showed that DNA methylation at variant exons could directly modify CD44 alternative splicing. This thesis work also explored the limitation and feasibility of studying alternative splicing with repurposed CRISPR systems
Jangal, Maïka. "Implication de TLE3 et KDM5A dans la régulation de la transcription des gènes cibles du récepteur des œstrogènes ERα". Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8952.
Texto completoMarques, Maud. "Étude de la régulation de l'expression de gènes cibles du récepteur aryl hydrocarbone dans des cellules cancéreuses de la glande mammaire". Thèse, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6557.
Texto completoBouchard, Marie France. "Fonctions aberrantes des facteurs de transcription GATA chez l'humain : régulation de l'expression ectopique du gène CYP19A1 par GATA 3/4 dans les cellules de cancer du sein et effet des mutations ponctuelle de GATA4 sur la régulation de ses gènes cibles gonadiques". Doctoral thesis, Université Laval, 2009. http://hdl.handle.net/20.500.11794/21206.
Texto completoTaffin, de Tilques Mathilde de. "Contrôle transcriptionnel de l'identité musculaire chez la drosophile : modules cis-régulateurs et gènes cibles directs de Collier". Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2232/.
Texto completoThe COE (Collier/Early B cell Factor) family is a metazoan-specific family of transcription factors (TF) that are involved in the control of numerous biological processes, including hematopoiesis, neurogenesis and muscle identity. Mutant analysis of COE TFs across several organisms showed defects in the specification of different cell types, like neuron subtypes or, in mammalians, B lymphocytes and brown adipocytes. However, the COE target genes are mostly unknown. Drosophila (fruit fly) is an excellent model to study the functional diversity of COE TFs. The core of my PhD work was the identification of Collier direct target genes in the DA3 muscle lineage, and the characterization of the corresponding CRM to better understand how COE proteins activate specific target genes in a tissue-dependent manner. I performed chromatin immuno-precipitation on whole embryos followed by systematic sequencing of the immuno-precipitated fragments (ChIPseq). By bio-informatics, I identified Col in vivo binding motif and showed that Col binding in vivo is context-dependent. Several candidate genes were validated by in situ hybridizations and functional analysis of the Col binding CRM. TF are over-represented among these targets. All together, the results reveal an unexpected complexity of gene regulatory networks that control muscle identity in Drosophila and confirm the critical role for Col in several transcription regulatory networks in the embryo. Considering the evolutionary conservation of COE proteins and their in vivo DNA binding properties, these results bring new insight into the complexity of COE function in other organisms, including mammals
Libros sobre el tema "Régulation ciblée de la transcription"
Klaus, Grasser, ed. Regulation of transcription in plants. Oxford: Blackwell Pub., 2006.
Buscar texto completoEukaryotic transcription factors. 4a ed. Oxford: Academic, 2004.
Buscar texto completoLatchman, David S. Eukaryotic transcription factors. 5a ed. Great Britain: Academic Press, 2008.
Buscar texto completoLatchman, David S. Eukaryotic transcription factors. 5a ed. Amsterdam: Elsevier/Academic Press, 2008.
Buscar texto completoT, Smale Stephen y NetLibrary Inc, eds. Transcriptional regulation in eukaryotes: Concepts, strategies, and techniques. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2000.
Buscar texto completoBryan, Cullen y Roche-UCLA Symposium on Mechanisms of Control of Gene Expression (1987 : Steamboat Springs, Colo.), eds. Mechanisms of control of gene expression: Proceedings of a Roche-UCLA Symposium, held at Steamboat Springs, Colorado, March 29-April 4, 1987. New York: Liss, 1988.
Buscar texto completoE, Davies K. y Tilghman Shirley M, eds. Gene expression and its control. Plainview, N.Y: Cold Spring Harbor Laboratory Press, 1991.
Buscar texto completoY, Chen Irvin S., ed. Transacting functions of human retroviruses. Berlin: Springer-Verlag, 1995.
Buscar texto completoM, Brown William y Philip M. Brown. Transcription. Taylor & Francis Group, 2001.
Buscar texto completoM, Brown William y Philip M. Brown. Transcription. Taylor & Francis Group, 2001.
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