Literatura académica sobre el tema "Rectum – Cancer – Aspect immunologique"

The clinical and anatomic analysis on the data autopsy is a prominent aspect of activity of hospitals which allows to reveal the reasons of death of patients, probable defects of medical-diagnostic process and is widely used for scientific researches. In work cases of death of patients from a heavy and unguided pathology - tromboemboly lang arteries are analysed at a cancer of rectum.

Cancer is one of the main causes of mortality in the world. Colorectal cancer, also known as colon cancer, is a malignant tumor of the colon and rectum that begins with a polyp. Early inspection is needed to prevent and cure of colorectal cancer because in the early stages colorectal cancer showed no symptoms. At this time the development of information technology allows the quick information retrieval from an image. The aim of this research is to produce a preliminary work in the stages of information analyzing on colorectal endoscopic image extraction result in the form of polyp and bleeding by utilizing extraction technique of image information based on shape and texture. This research aimed can be the basis for the development of colorectal cancer detection system framework. The research that has been carried out gives result of characteristics that can be differentiate between colon bleeding, colon polyp, and normal colon conditions, they are aspect ratio, triangle, correlation, and energy.

312 Background: The use of rectal spacers in the management of localized prostate cancer treated with definitive radiotherapy has become ubiquitous in recent years. However, pre-treatment MRIs often identify varying degrees of hydrogel involvement within the rectal wall. In the present study, we evaluate the geometry of spacer placement and its association with radiological rectal wall infiltration. Methods: We identified all patients who underwent hydrogel rectal spacer placement in preparation for 5-fraction prostate SBRT from 1/2020 to 9/2021. Two specialty trained body radiologists evaluated all MRIs independently. Scans were evaluated for the following spacer parameters: spacer thickness, prostate-rectal distance, symmetry, and degree of rectal wall infiltration. Prostate-rectal distance was measured at the level of the prostatic apex, midgland, and base. Symmetry of the rectal spacer was measured using right or left lateralization from midgland. Degree of rectal wall invasion was categorized as follows: none, muscularis, submucosal, and intraluminal. Results: A total of 336 patients underwent MRI following hydrogel rectal spacer placement from 1/2020 to 9/2021. Patients were excluded from MRI if they had AICD/pacemaker, foreign body, or patient refusal. In those patients with any rectal wall invasion, gel thickness as measured at the base (11 vs. 10 mm, p = 0.02), midgland (14 vs. 10 mm, p < 0.001), and apex (12 vs. 8 mm, P < 0.001) was significantly larger than those patients without invasion. This translated into significantly larger distances between the posterior aspect of the prostate and anterior aspect of the rectum at the level of the apex (12 vs. 8 mm, p < 0.001) and midgland (13 vs. 11, p < 0.001), but not at the base (14 vs. 14 mm, p = 0.5). There was no association seen with asymmetrical spacer placement and rectal wall invasion (p = 0.7). Subgroup analysis of patients with more extensive invasion into the muscularis or submucosa confirmed significantly larger gel thickness at all prostate levels, as well as a larger prostate-rectal distance at the level of the apex and midgland. Significant associations remained consistent with both independent radiological evaluations. Conclusions: Hydrogel spacer rectal wall infiltration was associated with increased axial gel thickness, specifically at the level of the prostatic midgland and apex. Rectal wall infiltration was not associated with lateralization of gel. Rectal infiltration may be a result of surplus hydrogel placed particularly in the region where the potential space between the prostate and the rectum is limited.

Intracavitary brachytherapy has an important roll in developing complications in postoperative radiotherapy of cervical cancer. 3D-CT based brachytherapy gives precisely estimating doses to organ at risk. In this study, we show our preliminary results in implementation of 3D-imaging based postoperative brachytherapy of cervical cancer: treatment technique and dose-volume parameters. During 2009 year, in 6 patients with early stage I-II of cervical cancer, brachytherapy treatment planning was based on the radiographs and CT imaging brachytherapy technique. Mean values of ICRU reference points of rectum was R max 4,2Gy and bladder B max. 4,5Gy, while estimated volume-dose parameters D0.1 cm 3 D1.0 cm 3 D2.0 cm 3 were presented with higher dose. Volume of organ at risk reflected the need for better bladder preparation. Our initial experience in performing CT-based brachytherapy, enabled us to introduce the characteristics of the parameters, assessment of their significance from the aspect of mutual relations applicators and organs at risk. Further analysis are needed, for monitoring the effects of 3D planning on complications.

Abstract N-NOSE, a breakthrough cancer detection test from HIROTSU BIO SCIENCE, utilizes the unique chemotactic behavior of the nematode C. elegans. This nematode is drawn to the urine of individuals with 15 different types of cancers (including stomach, colon-rectum, lung, breast, pancreas, liver, prostate, uterus, esophagus, gallbladder, bile duct, kidney, urinary bladder, ovary, oropharynx) while avoiding urine from healthy persons, making N-NOSE a comprehensive primary screening tool. It has a high accuracy rate, with 87.5% sensitivity and 90.2% specificity for early-stage cancers. Being non-invasive and reasonably priced, N-NOSE has been a significant success in Japan since its 2020 launch, with over 500,000 screenings.This presentation delves into the technology aspect of N-NOSE in Japan, comparing its clinical research and key findings with competitors to underscore its effectiveness in early cancer detection. Furthermore, N-NOSE now advances to not only detect cancer but also identify its type in a noninvasive way, using urine and with high PPV.With pancreatic cancer being particularly lethal, we outline “N-NOSE plus pancreas,” the world’s first pancreatic cancer detection test at an early stage. This involves genetically modifying C. elegans to react specifically to early-stage pancreatic cancer urine samples, a development centered on the newly identified cr-4 GPCR in AWC neurons. Next, we profile our newest liver-cancer-specific test, “N-NOSE plus liver,” which offers early liver cancer detection with high sensitivity and specificity using urine.Finally, we highlight how N-NOSE bridges the gap in cancer screening and type identification, offering a complete, non-invasive solution. Citation Format: Eric Di Luccio, Takaaki Hirotsu. Multi-cancer early cancer detection and cancer-type identification with high sensitivity non-invasive using urine: Pancreatic lung cancer early detection [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6091.

Cancer associated with colon is one of the principal risk factors from decease in women and men. Although importance growing aspect of human epidermis receptor2 (Her2) as a therapeutic target is rising its role as a biomarker in the form of predicting indicator within colorectal Cancer (CRC)is still a mystery. Present research is undertaken for evaluating the Her2/neu description in Cancer of the colon. This research comprises 256patientswith spectrum of histopathological treatment ranging from colitis to colorectal carcinoma at our department between 2015- 2017. Her2/neu Immunohistochemistry was done in the colorectal carcinoma and scores based on Ruschoff et al. Her-2 testing in gastric cancer. Out of a total number of 256 cases enrolled in our study group, the majority belonged to the age group of 40-60 years, with M: F ratio being 1.4:1. The commonest site of the lesion occurred in the rectum (43.75%) followed by ascending colon and caecum (12.08%). Non neoplastic lesions constituted about two third of all cases, the commonest being inflammatory bowel disease(21.48%). In benign neoplastic lesions of tubular adenoma was the commonest type, and in malignant commonest type was colorectal adenocarcinoma NOS(64.44%) followed by mucinous adenocarcinoma (22.22%). Because of more prominent membranous staining observed in high grade colorectal cancers, Her2neu expression is found to be an important predictive marker of carcinoma colon, especially the adenocarcinoma, NOS. Like Breast carcinoma, target oriented therapy can be instituted especially in Her 2/neu positive high grade and metastatic tumors.

Previous studies have demonstrated that microgravity could lead to health risks. The investigation of the molecular mechanisms from the aspect of systems biology has not been performed yet. Here, we integratively analyzed transcriptional and post-transcriptional regulations based on gene and miRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity. Two hundred and thirty dysregulated TF-miRNA (transcription factor and microRNA) feed-forward loops (FFLs) were identified in microgravity. The immune, cardiovascular, endocrine, nervous and skeletal system subnetworks were constructed according to the functions of dysregulated FFLs. Taking the skeletal system as an example, most of genes and miRNAs in the subnetwork were involved in bone loss. In addition, several drugs have been predicted to have potential to reduce bone loss, such as traditional Chinese medicines Emodin and Ginsenoside Rh2. Furthermore, we investigated the relationships between microgravity and 20 cancer types, and found that most of cancers might be promoted by microgravity. For example, rectum adenocarcinoma (READ) might be induced by microgravity through reducing antigen presentation and suppressing IgA-antibody-secreting cells’ migration. Collectively, TF-miRNA FFL might provide a novel mechanism to elucidate the changes induced by microgravity, serve as drug targets to relieve microgravity effects, and give new insights to explore the relationships between microgravity and cancers.

TPS137 Background: Prostatectomy has become the most common treatment for high-risk prostate cancer. After prostatectomy, risk features for local recurrence include extra-capsular extension and/or seminal vesicle invasion (pT3 disease) and positive surgical margins. Post-operative radiotherapy is recommended for patients with pT3 disease, positive margins and/or Group Grade 4-5 and has been shown to reduce the risk of recurrence. In planning adjuvant radiotherapy, the clinical target volume is the prostate bed which is difficult to delineate once the prostate has been surgically removed and can be overestimated by following the location of surgical clips. As such, controversy exists as to the optimal target volume. Guidelines suggest including a significant portion of the posterior and inferior aspects of the bladder, and anterior aspect of the rectum exposing a significant amount of normal tissue to high dose radiation. Pre-operative radiotherapy potentially offers the following advantages: 1) reduced radiation dose to normal tissues; 2) ability to utilize stereotactic body radiotherapy (SBRT) with real-time MRI guidance 3) patient convenience with less fractions and 4) radiobiologic advantage of high dose per fraction treatment delivery. Methods: This is a modified dose escalation trial for patients with high-risk prostate cancer defined as cT3 on MRI or Group Grade 4-5 disease. Patients will sequentially undergo 1) placement of a rectal SpaceOAR, 2) SBRT on the ViewRay MRIdian linear accelerator and 3) prostatectomy. As a modified dose escalation study, patients will be accrued starting at 5 Gy x 5 (up to 8 Gy x 5) with 3 patients per cohort with Grade 4 or 5 gastrointestinal (GI) and/or genitourinary (GU) adverse event related to preoperative radiotherapy as an unacceptable dose limiting toxicity.The primary endpoint is that a patient can undergo a radical prostatectomy after SBRT without a post-operative GI or GU grade 4 or 5 toxicity within 30 days related to preoperative radiotherapy. Secondary objectives include assessment of acute toxicity and quality of life scores. Exploratory analyses include analysis of tumor and normal biopsied and resected tissue and serum markers and interpretation of pre- and post-SBRT MRIs. Clinical trial information: NCT03663218.

e12534 Background: The smoking continuation during chemotherapy treatments affects positive results. As reported for instance by Mazza et al. in the review "Taking care of smoker cancer patients: a review and some recommendations" (Ann Oncol. 21(7):1404-9, 2010), nicotin seems to inhibit the potential of cisplatin in determining tumor cell death (Int J Oral Maxillofac Surg 2007; 36: 739–744), while some new anti-cancer drugs can give an excellent response only in people who have never smoked (Proc Natl Acad Sci U S A 2004; 101(36): 13306–13311). Methods: It is an observational monoistitutional analysis. The analysis covered 886 patients undergoing chemotherapy at the Veneto Oncology Institute of Padua during an observation period of six years (from 2006 to 2011). We have been taken into account all patients included in the Onco-AIFA national register for the monitoring of innovative anticancer drugs, focusing on the three big killer diseases: colon and rectum cancer (40% of the sample analyzed), lung cancer (36%) and breast cancer (24%). The Kaplen-Meier method was used to analyze the overall survival data. Results: Among the information collected, the aspect of smoking was taken into account: it was possible to extract the data for about half of the patients (n = 473), 48% of whom were non-smokers, 31% were smokers and the remaining 21% ex-smokers. Although there are three types of cancer that have three different natural histories, the study revealed that being a smoker or ex-smoker is a determinant of the OS of patients: in particular non-smokers showed a median survival of 27 months, ex-smokers of 18 and smokers of 13 (p <0.001). Conclusions: It should be noted then, that in the entirety of the sample smoking continuation reduces survival. Therefore, in addition to an increased risk, there is a reduced benefit in terms of clinical conditions and response since tobacco reduces the effects of anticancer chemotherapy. That being so, although the data are still preliminary, every effort must be made to ensure that a patient stops smoking during chemotherapy treatments as it has been demonstrated that the ex-smokers live an average 6 months longer.

Recent years have witnessed an unprecedented growth in the research area of nanomedicine. There is an increasing optimism that nanotechnology applied to medicine will bring significant advances in the diagnosis and treatment of various diseases, including colorectal cancer (CRC), a type of neoplasm affecting cells in the colon or the rectum. Recent findings suggest that the role of microbiota is crucial in the development of CRC and its progression. Dysbiosis is a condition that disturbs the normal microbial environment in the gut and is often observed in CRC patients. In order to detect and treat precancerous lesions, new tools such as nanotechnology-based theranostics, provide a promising option for targeted marker detection or therapy for CRC. Because the presence of gut microbiota influences the route of biomarker detection and the route of the interaction of nanoparticle/drug complexes with target cells, the development of nanoparticles with appropriate sizes, morphologies, chemical compositions and concentrations might overcome this fundamental barrier. Metallic particles are good candidates for nanoparticle-induced intestinal dysbiosis, but this aspect has been poorly explored to date. Herein, we focus on reviewing and discussing nanotechnologies with potential applications in CRC through the involvement of gut microbiota and highlight the clinical areas that would benefit from these new medical technologies.

Dans ce travail de thèse, j’ai analysé la qualité de l’infiltrat immunitaire des cancers du rectum localement avancés (LARC) et montré qu’une adaptation du test Immunoscore aux biopsies diagnostiques (ISB : infiltration tumorale en lymphocytes T CD3+ et CD8+) était réalisable. Sur deux cohortes (n1 = 131, n2=118) de patients LARC traités par radiochimiothérapie néoadjuvante (nRCT) avant chirurgie, j’ai observé que la qualité de l’infiltrat immunitaire, évalué par ISB, avait une valeur pronostique en termes de survie sans récidive [HR= 0.21 ; 95%CI 0.06-0.78, P=0.009], et était prédictive de la qualité de la réponse à la nRCT (P<0.001). Les analyses transcriptomiques et protéiques tumorales ont montré une hétérogénéité de réponse immunitaire locale à la nCRT. Une augmentation significative du niveau d’expression de gènes impliqués dans la cytotoxicité (GZMA, GZMH, GZMK, PRF-1), la réponse Th1 (TBX21, STAT4), l’activation (CD69) et la co-stimulation inhibitrice (CTLA-4, LAG3) était observée chez les patients répondeurs. Le statut d’activation immunitaire post-nCRT, était corrélé à l’ISB initial. L’ISB couplé aux examens d’imagerie post-nRCT améliore la prédiction de réponse complète histologique à la nRCT, et donc la sélection de patients éligibles à une stratégie de conservation d’organe (Watch&Wait, W&W). Sur 2 cohortes indépendantes de patients W&W, un ISB High prédisait un faible risque de récidive à 5 ans (3% ; CI95% 0-10%). Enfin, nous avons montré que les patients répondeurs à la nRCT pourraient présenter des signes de stimulation immunitaire adaptative T et B, soulignant le bénéfice immunitaire d’une préservation d’organe (et des ganglions drainants) en situation de réponse à la nCRT
In this work, I analyzed the quality of the immune infiltrate of locally advanced rectal cancer (LARC) and showed that an adaptation of the Immunoscore test to diagnostic biopsies (ISB: tumor infiltration in T cells CD3+ and CD8+) was feasible. In two cohorts (n1=131, n2=118) of LARC patients treated with neoadjuvant radiochemotherapy (nRCT) before surgery, I observed that the quality of the immune infiltrate, assessed by ISB, had a prognostic value in terms of recurrence-free survival [HR= 0.21; 95%CI 0.06-0.78, P=0.009], and was predictive of the quality of the response to nRCT (P<0.001). Tumor transcriptomic and protein analyses showed heterogeneity in local immune response to nCRT. A significant increase in the expression level of genes involved in cytotoxicity (GZMA, GZMH, GZMK, PRF-1), Th1 response (TBX21, STAT4), activation (CD69) and inhibitory costimulation (CTLA-4, LAG3) was observed in responder patients. The post-nCRT immune activation status correlated with the initial ISB. ISB coupled with post-nRCT imaging improves the prediction of histological complete response to nRCT, and thus the selection of patients eligible for an organ preservation strategy (Watch&Wait, W&W). In 2 independent cohorts of W&W patients, a High ISB predicted a low risk of recurrence at 5 years (3%; CI95% 0-10%). Finally, we showed that nRCT responder patients could show evidence of adaptive T and B immune stimulation, highlighting the immune benefit of organ (and draining lymph node) preservation in the nRCT response setting

Nous avons analysé la relation entre le risque de cancer colorectal et la consommation de viande et de poisson dans la population qui participe dans l’Etude Prospective Européenne sur le Cancer et la Nutrition. Il s’agit d’une étude sur plus de 400 000 sujets volontaires de dix pays européens. Le risque de cancer colorectal apparaît lié à un niveau de consommation élevé de viande rouge. Le hazard ratio associé à une consommation supérieure à 160 grammes par jour par rapport à une consommation inférieure à 20 grammes par jour est de 1. 35 (95% IC=0. 96-1. 88). La consommation élevée de poisson semble diminuer le risque de cancer colorectal. Le hazard ratio pour une consommation de poisson supérieure à 80 grammes par jour par rapport à celle de moins de 10 grammes par jour est de 0. 69 (IC=0. 54-0. 88). La consommation de volailles n’a pas d’incidence sur le risque de cancer colorectal. Nous avons intégré par méta-analyse nos résultats avec ceux des études prospectives publiées entre 1990 et juin 2006. D’après 14 études, le risque relatif moyen associé aux niveaux de consommation de viande rouge les plus hauts par rapport aux niveaux les plus bas est de 1. 34 (95% CI=1. 09-1. 21). En ce qui concerne les niveaux de consommation de poisson les plus hauts par rapport aux niveaux les plus bas (treize études), le risque relatif moyen est de 0. 87 (95%CI=0. 78-0. 97). Nos résultats montrent qu’une diminution des apports de viande rouge parmi les gros consommateurs devrait conduire à une diminution du risque de cancer colorectal pour cette population. La consommation de fibre alimentaire et de poisson en grosses quantités semble diminuer le risque, mais cette relation doit être confirmée par d’autres études.

IntroductionLe cancer colorectal est la 2ème cause de mortalité par cancer en France (HAS, 2013) mais aussi le 3ème cancer le plus fréquent (INCa, 2014). Un dépistage organisé existe depuis 2008, pourtant, les taux de participation restent faibles : 33,5% en France (Santé Publique France, 20018). D’après la littérature, les principaux freins à la participation au dépistage sont le manque de confiance envers le système de soins (Clavarino et al, 2004) ; l’embarras, l’inconfort et le déplaisir accompagnant les procédures des tests (Varela et al, 2010) ; ou encore le manque de temps. Enfin, le manque de recommandations de la part du médecin représente l’un des freins les plus importants (Walsh et al, 2010 ; Powell et al, 2009). Le test Hémoccult II, utilisé dans le cadre du dépistage organisé jusqu’en mars 2015, a été remplacé par un nouveau test immunologique, jugé plus sensible, plus spécifique et plus fiable par la communauté médicale (INCa, 2014).Objectifs et méthodeAu regard des faibles taux de dépistage et des principaux freins identifiés dans la littérature, ce travail de thèse a pour but d’analyser les déterminants de la participation au dépistage à la fois du point de vue des patients mais aussi des médecins généralistes. De plus, il apparaît nécessaire d’évaluer les enjeux de l’arrivée du nouveau test immunologique.Ce travail doctoral est basé sur la technique de la triangulation (théorique, méthodologique et des données). Plus précisément, deux cadres théoriques validés et reconnus en psychologie sociale de la santé ont été mobilisés, à savoir la Théorie des Représentations Sociales (Moscovici, 1984), et la Théorie du Comportement Planifié (Ajzen et al, 1991), permettant l’adoption d’une approche compréhensive aussi bien que prédictive du dépistage. Trois études ont ainsi été développées :- Une étude qualitative par entretiens semi-directifs, menée auprès de 17 médecins généralistes, ayant pour but d’appréhender leurs représentations sociales du dépistage du cancer colorectal ainsi que la manière dont celui-ci peut s’ancrer dans leur pratique de recommandation ;- Une étude qualitative par focus groups, menée auprès de 29 participants issus de la population générale dont l’objectif était d’appréhender leurs représentations sociales du dépistage du cancer colorectal ainsi que les freins et facilitateurs à son adhésion.- Une étude quantitative par questionnaires, menée auprès de 160 participants issus de la population générale, visant à identifier les principaux prédicteurs de l’intention et du comportement de dépistage du cancer colorectal.Principaux résultatsL’analyse des entretiens a révélé une incohérence entre le rôle que les médecins pensent devoir jouer auprès des patients dans la prévention et le dépistage, et la réalité de leur pratique qui ne leur laisse que peu de temps à y consacrer. L’analyse des focus groups a révélé que les principaux freins à la participation au dépistage sont : le manque d’accessibilité du test (nécessité de consulter le médecin généraliste pour obtenir le kit de dépistage), une faible préoccupation pour la prévention, mais aussi le fait que le cancer colorectal se réfère à une partie du corps liée à un tabou, et considérée comme sale. Enfin, l’analyse des questionnaires a permis d’identifier plusieurs variables ayant une influence sur l’intention et le comportement de dépistage, à savoir : le comportement antérieur de dépistage, la fréquence de dépistage, le déni, la proximité sociale, les normes sociales et le contrôle comportemental perçu. Les analyses ont particulièrement mis en avant l’importance du contrôle comportemental perçu, pouvant agir directement sur le comportement sans passer par l’intention.ConclusionLes conclusions révèlent la pertinence d’allier une approche compréhensive à une approche prédictive. Nos perspectives proposent la mise en place d’interventions visant à améliorer le niveau de contrôle perçu de la population générale face à ce dépistage
IntroductionColorectal cancer is the second leading cause of cancer deaths in France (HAS, 2013) but also the third most common cancer (INCa, 2014). An organized screening programme has been put in place since 2008, but participation rates remain low: 33.5% in France (Santé Publique France, 2018). According to the literature, the main barriers to participation in screening are the lack of confidence in the health care system (Clavarino et al, 2004) ; embarrassment, discomfort and dissatisfaction accompanying testing procedures (Varela et al, 2010); or lack of time. Finally, the lack of general practitioners’ recommendations is one of the most significant obstacles (Walsh et al, 2010, Powell et al, 2009). The Hemoccult II test, used as part of organized screening until March 2015, was replaced by a new immunological test, considered more sensitive, more specific and more reliable by the medical community (INCa, 2014).Objectives and methodFaced with the low screening rates and main obstacles identified in the literature, this thesis aims at analyzing the determinants of screening participation, with both patient and general practitioner points of view. Moreover, it appears necessary to evaluate issues with the arrival of the new immunological test.This doctoral work is based on the technique of triangulation (theoretical, methodological and data triangulation). More precisely, two validated and recognized theoretical frameworks in health and social psychology were employed, namely the Theory of Social Representations (Moscovici, 1984), and the Theory of Planned Behaviour (Ajzen et al, 1991), allowing the adoption of a comprehensive approach as well as a predictive approach to studying screening participation. Three studies have been set up:- A qualitative study through semi-structured interviews, conducted with 17 general practitioners, aimed at understanding their social representations of colorectal cancer screening and how it can be anchored in their practice of recommendation;- A qualitative study by focus groups, conducted with 29 participants from the general population. The objective was to apprehend their social representations of colorectal cancer screening as well as the obstacles and facilitators to screening participation.- A quantitative study by questionnaire, including 160 participants from the general population, endeavours to identify the key predictors of colorectal cancer screening intention and behaviour.Main resultsThe analysis of interviews revealed an inconsistency between the role general practitioners think they should play with patients in prevention and screening, and the reality of their practice which leaves them insufficient time to devote to it. The focus group analysis revealed that the main barriers to participation in screening are: the lack of accessibility of the test (needing to consult the general practitioner in order to obtain the screening kit), a low concern for prevention, but also the fact that colorectal cancer refers to a body part that is deemed taboo, and considered “dirty”. Finally, the analysis of questionnaires allowed the identification of several variables influencing intention and behaviour of screening, namely: previous screening behaviour, frequency of screening, denial, social proximity, social norms and perceived behavioural control. Analysis particularly emphasized the value of perceived behavioural control, which can directly influence behaviour without going through intention.ConclusionResults reveal the relevance of combining a comprehensive approach with a predictive approach. Our perspectives suggest the implementation of interventions aimed at improving the perceived level of control of the general population faced with this screening

Abstract The treatment of benign prostatic hyperplasia (BPH) has implications which affect the majority of the adult male population. Although benign compared to prostate cancer, clinical symptoms can dramatically alter the quality of life. The hyperplastic tissue can cause constriction of the urethra and thus affect voiding of urine. Factors to consider for thermally-based treatments of the prostate include minimization of thermal injury to the urethra and rectum, and maximal delivery of thermal energy to target tissue. Minimizing temperature rise in the urethra allows for minimal or no anesthesia, and has been shown to reduce postoperative complications. Protection of the rectal wall is imperative since injury can lead to clinical complications as severe as a rectal fistula. Due to its location immediately dorsal to the prostate, the ventral aspect of the rectal wall is susceptible to overheating when a uniform radiating microwave heat source is applied transurethrally to treat the prostate. This paper summarizes the engineering technology. numerical modeling, and clinical results to date.