Literatura académica sobre el tema "Rebecca Osborne Smith Branch"

Abstract While there is no shortage of approved targeted therapeutics to address driver mutations in NSCLC, many patients are not tested for these alterations due to gaps in biomarker testing access. Challenges in NSCLC molecular testing include the need for assessment of multiple variants in both DNA and RNA, samples are often small specimens, cost, and clinical need for rapid turn-around time when patients are deteriorating and require timely treatment initiation. ASPYRE-Lung detects a targeted panel of 114 actionable genomic variants across 11 genes, covering NCCN treatment guideline-recommended biomarkers for samples that are associated with NSCLC. The assay simultaneously analyzes DNA and RNA with inputs of only 20 ng and 6 ng respectively. ASPYRE-Lung is easily adoptable by standard clinical laboratories, requiring only PCR and qPCR thermocyclers, with no specialist bioinformatics skills required for analysis and a run time of 2 days from specimen to result. We established the assay at two external sites and Biofidelity laboratories, with multiple operators at each site. We first determined that the assay had acceptable performance at each site, using a panel of contrived control samples. We then examined 56 matched DNA and RNA samples extracted from clinical FFPE lung tissue specimens. We also tested 29 unmatched samples derived from FFPE tissue (13), fine needle aspirate (FNA, 4), FNA rinse (5), peritoneal fluid (1), pleural effusion (1), pleural fluid (1) and fresh tissue (4), at all 3 sites. Data were analyzed using a simple cloud-based turnkey analysis solution. All samples yielded valid results across all runs. We assessed reproducibility (inter-run precision) using all 85 clinical samples, across new and experienced users, achieving a positive percent agreement (PPA) of 100% and negative percent agreement (NPA) of 99.99%. We then assessed concordance with NGS results, investigating any discrepancies. The 69 FFPE tissue-derived samples (56 matched DNA/RNA, 7 unmatched DNA, and 6 TNA) had PPA 96.55% and NPA 99.98%. The 16 cytopathology-derived samples had PPA 100% and NPA 99.96%. Together, these results demonstrate high concordance of ASPYRE-Lung and NGS across different types of clinical samples, alongside ease of adoption of the ASPYRE-Lung assay with simple training and no specialist expertise required. ASPYRE-Lung promises to enable all patients with NSCLC to start appropriate treatment in a cost-effective and timely manner. Citation Format: Sarah E. Herlihy, Caren Gentile, Samantha J. Scott, Brandon A. Smith, Kathryn A. Stoll, Kala F. Schilter, Justyna Mordaka, Rebecca Palmer, Christina Xyrafaki, Elizabeth Gillon-Zhang, Candace King, Ryan Evans, Amanda Green, Ana-Luisa Silva, Magdalena Stolarek-Januszkiewicz, Kristine von Bargen, Iyelola Turner, Chau Ha Ho, Alejandra Collazos, Nicola Potts, Dilyara Nugent, Jinsy Jose, Eleanor Gray, Elyse Shapiro, Wendy J. Levin, Aishling Cooke, Barnaby Balmforth, Robert Osborne, Honey V. Reddi, Vivianna M. Van Deerlin. Deployment of ASPYRE-Lung targeted variant panel across three sites and testing with FFPE tissue and cytology-derived nucleic acid samples [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5164.

Greetings everyone! Welcome to another issue and a round-up of children’s literature news. It has been a long and cold winter in Edmonton, but it seems to be finally winding down. There are some award and event news to share with you as well as some podcasts. I happen to be a big podcast lover and and my favourite ones help me get through the winter darkness with insightful ideas and discussions. It thought it would be fun to highlight a few children’s literature podcasts that may interest our readers. Here’s wishing you all a warm spring! AWARDS Alberta Literary Awards were announced by the Writers’ Guild of Alberta. The books shortlisted for the R. Ross Annett Award for Children’s Literature include: Jenny Keith (Edmonton) – Day Cat, Night Cat Mike Kerr (Calgary) – Crafty Llama Nhung Tran-Davies (Calmar) – Ten Cents a Pound Shortlist reading events will be held this spring in Edmonton on May 5 and in Calgary on May 15. The BC Book Prize shortlists have been announced, and titles shortlisted for the Sheila A. Egoff Children’s Literature Prize include: Learning to Breathe by Janice Lynn Mather The Journey Forward, A Novella on Reconciliation: When We Play Our Drums, They Sing! / Lucy and Lola by Monique Gray Smith and Richard Van Camp Nice Try, Jane Sinner by Lianne Oelke No Fixed Address by Susin Nielsen Very Rich by Polly Horvath Those shortlisted for the Christie Harris Illustrated Children’s Literature Prize include: The Nameless City: The Divided Earth by Faith Erin Hicks, Robert Bateman: The Boy Who Painted Nature by Margriet Ruurs Illustrated by Robert Bateman, Sir Simon: Super Scarer by Cale Atkinson; Sparks! by Ian Boothby Illustrated by Nina Matsumoto Sterling, Best Dog Ever by Aidan Cassie Full details can be found at the BC Book Prize Website. EVENTS Me and Mr. Carnegie: 16th Albert Lahmer Memorial Lecture The Osborne Collection of Early Children's Books, Lillian H. Smith Branch, Toronto Public Library April 25, 2019, 7:00 pm - 8:00 pm See more at: Canadian Children’s Book Centre CHILDREN’S AND YA PODCASTS YA Write Every month, Amy Mathers talks to YA writers about their inspiration as a writer and their latest books. Picturebooking A Podcast About Creating and Sharing Picture Books The Yarn A narrative adventure. The Yarn takes listeners behind the scenes of children's literature, and lets them look at all the threads that must be weaved together to create a book. The Children’s Book Podcast Hosted by Matthew Winner, elementary school librarian and co-founder of All The Wonders. The Children's Book Podcast features insightful and sincere interviews with authors, illustrators, and everyone involved in taking a book from a drawing board to bookshelf. Books Between A podcast about books for tweens around the ages 8-12. The podcast offers trending topics, author interviews, and recommendations.

Amy’s Marathon of Reading continues westward. Her Marathon of Hope project was mentioned in this column before but as it continues to gather momentum and as it relevant to the topic of this special issue, I thought it pertinent to mention it again. From her website: “ Inspired by Terry Fox’s and Rick Hansen’s Canadian journeys, Amy Mathers decided to honour her passion for reading and Canadian teen literature while working around her physical limitations through a Marathon of Books. Realising that Terry Fox could run a kilometre in six minutes during his Marathon of Hope, she figured out that she could read ten pages in the same amount of time. Thus, on her journey, ten pages will represent one kilometre travelled across Canada. Amy will be reading teen fiction books from every province and territory, exploring Canada and promoting Canadian teen authors and books by finishing a book a day for each day of 2014. She will write a review for each book she reads, and invites people to share their thoughts on the books she reads too.” For more information and to see how far Amy’s marathon has taken her so far, go to http://amysmarathonofbooks.ca/Upcoming events and exhibitsKAMLOOPS WRITERS FESTIVAL, Nov. 7-9, 2014, Old Courthouse Cultural Centre. Guest authors include children’s author Lois Peterson.WORKSHOP: Reading Challenges and Options for Young People with Disabilities. Friday, November 14, 2014; 11:30 am to 1:00 pm. REGISTRATION and more information: https://www.microspec.com/tix123/eTic.cfm?code=BOOKFAIR14 International and Canadian experts will discuss reading challenges and options for children and teens with disabilities, with examples from the IBBY Collection of Books for Young People with Disabilities. This outstanding international collection, formerly in Norway and now housed at North York Central Library, encompasses 3,000 books in traditional formats and accessible formats including sign language, tactile, Braille, and Picture Communication Symbols.There are two major opportunities to hear award winning author Kit Pearson in Toronto and Vancouver in the upcoming months. Kit will be presenting “The Sanctuary of Story” for the 8th Annual Sybille Pantazzi Memorial Lecture on Thursday November 13, 8 p.m., in the Community room, Lillian H. Smith branch of the Toronto Public Library.Kit Pearson will also be the guest speaker at A Celebration of Award Winning BC Authors and Illustrators of 2014 at A Wine and Cheese event from 7 – 9 p.m. at January 21, 2015. (Event venue still to be confirmed. Please check www.vclr.ca for updates.) The event celebrates many other BC winners and finalists of the Governor General’s Literary Awards, the BC Book Prizes, the VCLR Information Book Award, and several other important awards.For those of you in the Toronto area be sure to check out the exhibit Lest We Forget: War in Books for Young Readers, September 15 – December 6, 2014, at the Osborne Collection. In commemoration of the 100th anniversary of the beginning of the First World War.Do not forget to Celebrate Freedom to Read Week, February 22-28, 2015, the annual event that encourages Canadians to think about and reaffirm their commitment to intellectual freedom, which is guaranteed them under the Charter of Rights and Freedoms.Serendipity 2015 promises to be a tantalizing affair. An Edgy, Eerie, Exceptional Serendipity 2015 (Saturday March 7, 2015) with Holly Black, Andrew Smith, Mariko Tamaki, Molly Idle, and Kelli Chipponeri will have captivating discussions ranging from haunted dolls and worlds of nightmare, to the raw emotion and exceptional beauty of growing up. The event, a members-only event, includes breakfast, lunch, and snacks. [This may be a very good incentive to become a member!] More information at http://vclr.ca/serendipity-2015/Call for papers and presentationsYALSA is currently seeking program proposals and paper presentations for its 2015 Young Adult Services Symposium, Bringing it All Together: Connecting Libraries, Teens & Communities, to be held Nov. 6-8, 2015, in Portland, Ore. The theme addresses the key role of connection that librarians have for the teens in their community. YALSA invites interested parties to propose 90-minute programs centering on the theme, as well as paper presentations offering new, unpublished research relating to the theme. Applications for all proposals can be found http://www.ala.org/yalsa/yasymposium . Proposals for programs and paper presentations must be completed online by Dec. 1, 2014. Applicants will be notified of their proposals’ status by Feb. 1, 2015.Book Award newsThe 2014 Information Book Award Finalists. The winner and honor title, voted by members of the Children’s Literature Roundtables, will be announced November 17, 2014 in Vancouver.Before the World Was Ready: Stories of Daring Genius in Science by Claire Eamer. Annick Press. Follow Your Money by Kevin Sylvester and Michael Hlinka. Annick Press.Looks Like Daylight: Voices of Indigenous Kids by Deborah Ellis. Groundwood Books. Pay It Forward Kids: Small Acts, Big Change by Nancy Runstedler. Fitzhenry & Whiteside.Pedal It! How Bicycles are Changing the World by Michelle Mulder. Orca Book Publishers.The list of nominees for the 2015 Astrid Lindgren Memorial Award (ALMA) includes 50 first-time nominees among a total of 197 candidates from 61 countries. Canadian nominees include The Canadian Children’s Book Centre (Organisation, nominated by IBBY Canada) and authors Sarah Ellis and Marie-Francine Hébert. Full list available at http://www.alma.se/en/Nominations/Candidates/2015/The winners of the 2014 Governor General’s Literary Award will be announced November 18, 2014. The nominated titles for children’s literature (English text) are:Jonathan Auxier, (Pittsburgh, Pa.) – The Night Gardener (Penguin Canada)Lesley Choyce, (East Laurencetown, N.S.) – Jeremy Stone (Red Deer Press)Rachel and Sean Qitsualik-Tinsley – Skraelings (Inhabit Media Inc.)Raziel Reid, (Vancouver) – When Everything Feels like the Movies (Arsenal Pulp Press)Mariko Tamaki, (Oakland, Calif.) – This One Summer (Groundwood Books/House of Anansi Press)Nominations for illustration in (English) children’s literature are:Marie-Louise Gay, (Montreal) – Any Questions?, text by Marie-Louise Gay (Groundwood Books/House of Anansi Press)Qin Leng, (Toronto) – Hana Hashimoto, Sixth Violin, text by Chieri Uegaki (Kids Can Press)Renata Liwska, (Calgary) – Once Upon a Memory, text by Nina Laden (Little, Brown and Company)Julie Morstad, (Vancouver) – Julia, Child, text by Kyo Maclear (Tundra Books)Jillian Tamaki, (Brooklyn, N.Y.) – This One Summer, text by Mariko Tamaki (Groundwood Books/House of Anansi Press)Nominations for (French) children’s literature (text) are:Linda Amyot, (St-Charles-Borromée, Que.) – Le jardin d'Amsterdam (Leméac Éditeur)India Desjardins, (Montreal) – Le Noël de Marguerite (Les Éditions de la Pastèque)Patrick Isabelle, (Montreal) – Eux (Leméac Éditeur)Jean-François Sénéchal, (Saint-Lambert, Que.) – Feu (Leméac Éditeur)Mélanie Tellier, (Montreal) – Fiona (Marchand de feuilles)Nominations for (French) children’s literature (illustration):Pascal Blanchet, (Trois-Rivières, Que.) – Le Noël de Marguerite, text by India Desjardins (Les Éditions de la Pastèque)Marianne Dubuc, (Montreal) – Le lion et l'oiseau, text by Marianne Dubuc (Les Éditions de la Pastèque)Manon Gauthier, (Montreal) – Grand-mère, elle et moi…, text by Yves Nadon (Éditions Les 400 coups)Isabelle Malenfant, (Montreal) – Pablo trouve un trésor, text by Andrée Poulin (Éditions Les 400 coups)Pierre Pratt, (Montreal) – Gustave, text by Rémy Simard (Les Éditions de la Pastèque)Online resources:Welcome to the Teachers' Book Bank! This database of Canadian historical fiction and non-fiction books is brought to you by the Canadian Children's Book Centre with Historica Canada, and funded by the Government of Canada. These titles may be used by teachers to introduce topics and themes in Canadian history and by students carrying out research projects. Many of the books also offer opportunities for cross-curricular connections in language arts, geography, the arts, science and other subjects. In most cases, publishers have indicated specific grade levels and age ranges to guide selection. For lesson plans to go with these books, visit Historica Canada's Canadian Encyclopedia. http://bookbank.bookcentre.ca/index.php?r=site/CCBCChairing Stories on Facebook Created in response to requests from former students of Gail de Vos’s online courses on Canadian Children’s Literature and Graphic Novels and comic books, this page celebrates books, their creators, and their audiences. Postings for current students too! Check it out at https://www.facebook.com/ChairingStoriesPresented by Gail de VosGail de Vos, an adjunct instructor, teaches courses on Canadian children's literature, Young Adult Literature and Comic Books and Graphic Novels at the School of Library and Information Studies for the University of Alberta and is the author of nine books on storytelling and folklore. She is a professional storyteller and has taught the storytelling course at SLIS for over two decades