Artículos de revistas: "Rabbits Anatomy"

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Reichert, P., R. Rutowski, Z. Kiełbowicz, J. Kuryszko, M. Kiełbowicz, Ł. Michalak y A. Bocheńska. "The rabbit brachial plexus as an experimental model – anatomy and surgical approach". Polish Journal of Veterinary Sciences 17, n.º 2 (1 de junio de 2014): 339–45. http://dx.doi.org/10.2478/pjvs-2014-0046.

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AbstractThe aim of our study was to analyze the anatomy and surgical approach of the rabbit brachial plexus. The research included 18 rabbits. The rabbit seems to be a good experimental model for spinal nerves injury, especially for the C5 and C6 segments. The anatomical structure of the rabbit’s brachial plexus is similar to the human brachial plexus. The structure of the rabbit C5 and C6 segments is analogous to the human structure. The spinal nerves of the C5 and C6 segments in the rabbit are wide and long enough for microsurgical procedures

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Crossley, David A. "Clinical Aspects of Lagomorph Dental Anatomy: The Rabbit (Oryctolagus cuniculus)". Journal of Veterinary Dentistry 12, n.º 4 (diciembre de 1995): 137–40. http://dx.doi.org/10.1177/089875649501200402.

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The lagomorphs most commonly encountered as pets are rabbits. There are many breeds of domestic rabbit, varying from dwarf varieties with an adult weight of under one kilogram to giants weighing 10kg. This article provides a working knowledge of the dental anatomy and physiology of rabbits so that veterinarians can interpret clinical and radiographic findings when investigating rabbits with suspected dental disease.

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Greenaway, JB, GD Partlow, NL Gonsholt y KR Fisher. "Anatomy of the lumbosacral spinal cord in rabbits". Journal of the American Animal Hospital Association 37, n.º 1 (1 de enero de 2001): 27–34. http://dx.doi.org/10.5326/15473317-37-1-27.

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This study provides an accurate, anatomical description of the rabbit's lumbosacral spinal cord. Following humane euthanasia, 64 rabbits were radiographed and dissected. The number of thoracic (T) and lumbar (L) vertebrae was 12T/7L in 43.8%, 13T/6L in 32.8%, and 13T/7L in 23.4% in the 64 rabbits studied. The 13th ribs were rudimentary, asymmetric, or both in 15 animals. The spinal cord terminated within the second sacral vertebra (S2) in 79.3%, within the first sacral vertebra (S1) in 19.0%, and within the third sacral vertebra (S3) in 1.7% of the sample. Spinal nerve contributions to the femoral, obturator, sciatic, and pudendal nerves were determined. Formulas to predict the termination of the cord relative to the vertebral column were established. Age, weight, sex, and method of preparation did not show a significant correlation with the length of the spinal cord.

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Worthley, S. G., M. Roque, G. Helft, K. Soundararajan, M. Siddiqui y E. D. Reis. "Rapid oral endotracheal intubation with a fibre-optic scope in rabbits: a simple and reliable technique". Laboratory Animals 34, n.º 2 (1 de abril de 2000): 199–201. http://dx.doi.org/10.1258/002367700780457554.

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The orotracheal intubation of rabbits is complicated by their oropharyngeal anatomy. Numerous techniques to intubate rabbits have been described; however, these methods require specialized devices, tracheostomy, or are performed in a blind fashion. We describe a technique for the intubation of the rabbit under direct visualization with a standard, small-bore, fibre-optic laparoscope, which is both rapid and simple to perform.

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Claassen, E. y L. T. Adler. "Sequential double immunocytochemical staining for in situ identification of an auto-anti-allotype immune response in allotype-suppressed rabbits." Journal of Histochemistry & Cytochemistry 36, n.º 12 (diciembre de 1988): 1455–61. http://dx.doi.org/10.1177/36.12.3057069.

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Immunocytochemical staining has been used to detect putative autoimmune B-cells in rabbits undergoing chronic allotype suppression. This condition is seen in heterozygous rabbits exposed perinatally to antibody against the paternal immunoglobulin allotype. Such animals develop lifelong suppression for this allotype and have been used as models for study of antibody-induced disturbance of immune regulation. Normal rabbits deliberately immunized against a heterologous allotype were used to establish the feasibility of identifying cells forming anti-allotypic antibodies in cryostat sections of rabbit lymphoid tissues. Incubation and staining of tissue sections from suppressed rabbits then revealed the presence of autoimmune B-cells, with antibody specificity for the suppressed allotype, in all chronically suppressed adult rabbits tested. Sequential incubation and staining with allotype- and anti-allotype-enzyme conjugates established that such cells were of non-suppressed origin. Auto-anti-allotype antibody-forming cells were not found in normal heterozygotes or in chimeric rabbits. The immunocytochemical techniques described here permitted simultaneous detection of specificity (i.e., anti-allotype) and origin (allotype) of antibody-forming cells involved in an autoimmune response, as well as their anatomical correlation with other B-cells of suppressed or non-suppressed origin. Since the method described can be adapted to detection of alternate cell markers, we believe it to have potential application to the study of other autoimmune phenomena.

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Regalado, Adriana y Loïc Legendre. "Full-Mouth Intraoral Radiographic Survey in Rabbits". Journal of Veterinary Dentistry 34, n.º 3 (16 de agosto de 2017): 190–200. http://dx.doi.org/10.1177/0898756417723145.

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Dental pathologies are highly prevalent in pet rabbit populations, making oral radiography an essential tool in the evaluation of lagomorph dentitions. The unique anatomy of the rabbit’s mouth limits the examination of the conscious animal to the rostral portion of it's mouth. In addition, the oral examination of an aradicular hypsodont tooth is restricted to the short coronal fraction of its crown. Erstwhile images obtained by the extraoral technique were once considered the most practical and informative tool in rabbit dentistry; however, limited visualization of the key structures of individual teeth became the major drawback of this technique. As new imaging technologies are becoming widely available and affordable for veterinarians, intraoral radiography offers the ability to prevent, diagnose, and treat oral pathologies in lagomorphs. This article describes a step-by-step procedure to obtain a full-mouth radiographic survey in rabbits. For this technique, a standard dental X-ray generator and intraoral storage phosphor plates are used while applying the bisecting angle technique. Among the advantages of this technique are detailed visualization of internal and external dental structures, identification of early lesions, and detection of occult pathologies. Furthermore, intraoral images offer superior resolution and higher diagnostic quality with minimal radiation exposure, making this method safer for the veterinarian, staff members, and their patients.

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Chmurska, Maria, Natalia Sowińska y Agnieszka Pietsch-Fulbiszewska. "Dental anesthesia in small mammals on the example of domestic rabbits". Medycyna Weterynaryjna 73, n.º 4 (2017): 208–13. http://dx.doi.org/10.21521/mw.5682.

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The domestic rabbit (Oryctolagus cuniculus f. domesticus) has become a very popular companion animal kept at present in Europe. Dental problems in rabbits are prevalent. The medical procedure in these patients is based primarily on surgical treatment, which is associated with pain during treatment. This paper aims to familiarize readers with the techniques of local anesthesia, which can be used in dentistry of the domestic rabbit. The study summarizes the specifics of the anatomy of the rabbit skull. On the basis of original papers, in which the domestic rabbit or other small mammals were the research model, the drugs used for local anesthesia and techniques of local anesthesia with possible complications have been described in the present work.

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Morrissey, Patrick J., Kevin R. Murphy, Jean M. Daley, Lorraine Schofield, Nilufer N. Turan, Karuppiah Arunachalam, J. Dawn Abbott y Gideon Koren. "A novel method of standardized myocardial infarction in aged rabbits". American Journal of Physiology-Heart and Circulatory Physiology 312, n.º 5 (1 de mayo de 2017): H959—H967. http://dx.doi.org/10.1152/ajpheart.00582.2016.

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The incidence of both myocardial infarction (MI) and sudden cardiac death increases with age. Here, we describe the development of a minimally invasive large animal model of MI that can be applied to young or aged animals. We demonstrate that rabbit coronary anatomy is highly variable, more so than described in previous literature. In this work, we categorize the coronary pattern of 37 young rabbits and 64 aged rabbits. Aged rabbits had a higher degree of branching from the left main coronary artery. Standardizing the model across age cohorts required a new approach, targeting an area of myocardium rather than a specific vessel. Here, we present a method for achieving a reproducible infarct size, one that yielded a consistent scar encompassing ~30% of the apical left ventricular free wall. The model’s consistency allowed for more valid comparisons of MI sequelae between age cohorts. NEW & NOTEWORTHY This study describes the coronary angiographic imaging of young and aged rabbits. We developed and improved a novel minimally invasive approach for coil embolization that targets a specific area of myocardium and yielded a consistent scar encompassing ~30% of the left ventricular free wall of young and aged rabbit hearts.

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Rich, K. J., J. R. Foster, R. J. Edwards, D. S. Davies y A. R. Boobis. "Ontogenetic development of the distribution of constitutive and 3-methylcholanthrene-induced CYP1A1 and CYP1A2 in rabbit liver." Journal of Histochemistry & Cytochemistry 41, n.º 6 (junio de 1993): 915–25. http://dx.doi.org/10.1177/41.6.8315282.

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We investigated the expression, distribution, and inducibility of 3-methylcholanthrene (MC)-inducible P450 enzymes, CYP1A1 and 1A2, in livers of rabbits at different stages of development, ranging from 4 days before birth (-4 days of age) to adulthood. These enzymes were identified by immunoblotting and immunocytochemistry and quantified by dot-blotting, utilizing previously characterized monoclonal antibodies, 107 and 3/4/2, specific for CYP1A2 and both CYP1A1 and 1A2, respectively, and a polyclonal antibody that recognizes both enzymes. Expression of CYP1A2 is always greater than that of CYP1A1 in livers of untreated rabbits, regardless of age. Moreover, immunocytochemistry showed that CYP1A1 is evenly distributed throughout the liver at all ages, whereas CYP1A2 is highly localized to only a few scattered cells at 1 day before birth. More hepatocytes express this enzyme perinatally. By 6 days of age, expression of CYP1A2 is confined to a narrow band of centrilobular cells, but with increasing age the enzyme is expressed in more hepatocytes until weaning, when all hepatocytes are positive. Although CYP1A1 is induced by MC treatment at most ages, there is no change in its distribution. In contrast, induction of CYP1A2 was shown immunocytochemically to occur in only a limited number of hepatocytes in fetal rabbits. There is a progressive increase with age in the number of hepatocytes that are inducible for CYP1A2. The greatest fold-induction of hepatic CYP1A2 by MC in the rabbit is a 9-11 days of age, when, for MC-treated rabbits, CYP1A2 represents > 60% of the total P450 pool. The modulation of enzyme expression caused by MC treatment of fetuses/neonates leads to developmentally advanced livers with respect to P450 and could have a significant impact on the fetal and neonatal toxicity of some foreign compounds. These data demonstrate, for the first time, that the ontogenetic expression and localization of CYP1A1 and 1A2 within the liver are differentially regulated at the level of the individual cell.

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Feldenzer, John A., Paul E. McKeever, Dennis R. Schaberg, John A. Campbell y Julian T. Hoff. "The pathogenesis of spinal epidural abscess: microangiographic studies in an experimental model". Journal of Neurosurgery 69, n.º 1 (julio de 1988): 110–14. http://dx.doi.org/10.3171/jns.1988.69.1.0110.

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✓ An experimental model of spinal epidural abscess was developed in rabbits by injecting Staphylococcus aureus into the posterior thoracolumbar epidural space. This model has been shown to reproduce the neurological, bacteriological, and radiological aspects of the human disease. In this study, the effect of the infectious epidural mass on the vasculature of the spinal cord in paraplegic rabbits was studied using microangiographic techniques. The normal vascular anatomy of the rabbit spinal cord was defined in control experiments. Vascular proliferation was demonstrated in the epidural space surrounding the abscesses. Anterior and paired posterior spinal arteries remained patent in paraplegic rabbits with mild or moderate spinal cord compression and in some cases of severe compression. In animals with severe compression, the anterior epidural venous plexus remained patent, but the dorsal spinal vein was occluded. Occlusion of perforating arteries occurred only with extreme spinal cord compression. These data indicate that the initial neurological deficit associated with experimental spinal epidural abscess is not due to vascular thrombosis.

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11

Lobprise, Heidi B. y Robert B. Wiggs. "Dental and Oral Disease in Lagomorphs". Journal of Veterinary Dentistry 8, n.º 2 (junio de 1991): 11–17. http://dx.doi.org/10.1177/089875649100800205.

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The dental diseases of rabbits are unique because of their dental anatomy and physiology. Common problems of Lagomorph dentition are covered in this article including malocclusions, periodontal disease, and their treatment. The anatomy of Lagomorph dentition is reviewed and anesthesia protocols are included.

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Abidu-Figueiredo, Marcelo, Bárbara Xavier-Silva, Themis M. Cardinot, Márcio A. Babinski y Maurício A. Chagas. "Celiac artery in New Zealand rabbit: anatomical study of its origin and arrangement for experimental research and surgical practice". Pesquisa Veterinária Brasileira 28, n.º 5 (mayo de 2008): 237–40. http://dx.doi.org/10.1590/s0100-736x2008000500002.

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Rabbits have been used as an experimental model in many diseases and for the study of toxicology, pharmacology and surgery in many universities. However, some aspects of their macro anatomy need a more detailed description, especially the abdominal and pelvic arterial vascular system, which has a huge variability in distribution and trajectory. Thirty cadaveric adult New Zealand rabbits, 13 male and 17 female, with an average weight and rostrum-sacral length of 2.5 kg and 40cm, respectively, were used. The thoracic aorta was cannulated and the vascular system was filled with stained latex S-65. The celiac artery and its proximal branches were dissected and lengthened in order to evidence origin and proximal ramifications. The celiac artery emerged between the 12th and 13th thoracic vertebra in 11 (36.7%) rabbits; at the level of the 13th thoracic vertebra in 6 (20%) rabbits; between the 13th thoracic vertebra and the 1st lumbar vertebra in 12 (40%) rabbits; and at the level of the 1st lumbar vertebra in only one (3.3%) rabbit. The mean length of the celiac artery was 0.5cm. The celiac artery first branch was the lienal artery, the second branch was the left gastric artery and the hepatic artery arose from the left gastric artery in all the dissected rabbits. No relation was observed between the celiac artery length and the rostrum-sacral length in rabbits. The number of left gastric and lienal artery branches and the distribution of celiac artery origin are not gender dependent.

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Sundarraj, N., J. Chao, J. D. Gregory y S. P. Damle. "Ocular distribution of keratan sulfates during pre- and postnatal development in rabbits." Journal of Histochemistry & Cytochemistry 34, n.º 8 (agosto de 1986): 971–76. http://dx.doi.org/10.1177/34.8.2426337.

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Twenty-six monoclonal antibodies (MAbs) developed against rabbit corneal proteokeratan sulfate (PKS), were used to evaluate immunohistochemically the ocular distribution of PKS during prenatal and early postnatal development in rabbits. These MAbs were directed against epitopes located in the keratan sulfate (KS) chains of the proteoglycan (SundarRaj et al., 1985). Staining of cryostat sections of the eyes was carried out using an indirect peroxidase-conjugated technique. Only one of the MAbs reacted with the presumptive corneal region at day 13 or 16 of fetal development. By day 20, more MAbs reacted with the corneal stroma. There were distinct differences, however, in the distribution of the epitopes recognized by the various MAbs. A few of them stained only the posterior region of the cornea, whereas others showed a decreasing staining gradient from the posterior to the anterior region. By day 24, all of the MAbs reacted with the corneal stroma, but some reacted also with the limbal region and with the conjunctival stromal matrix. One MAb also reacted with the conjunctival epithelial layer, but only at this stage of development. Conjunctival staining was more intense at day 28 of fetal development and at day 2 postnatally. KS was not detectable in the conjunctiva of adult rabbits with any of the MABs. These results suggest that although KS synthesis starts at very early stages of fetal development, there are progressive changes in its antigenic structure in specific regions of the cornea and conjunctiva during corneal development.

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Van Rooijen, N. y N. Kors. "Double immunocytochemical staining in the study of antibody-producing cells in vivo. Combined detection of antigen specificity (anti-TNP) and (sub)class of intracellular antibodies." Journal of Histochemistry & Cytochemistry 33, n.º 3 (marzo de 1985): 175–78. http://dx.doi.org/10.1177/33.3.2579119.

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Mice and rabbits were immunized with trinitrophenyl (TNP)-conjugated keyhole limpet hemocyanin (KLH). Cells producing specific antibodies against the hapten TNP were detected in vivo in spleen and lymph nodes using a TNP--alkaline phosphatase (AP) conjugate. Using horseradish peroxidase (HRP)-conjugated anti-mouse (sub)class (IgG2A, IgG2B, IgM) antibodies and anti-rabbit class (IgG, IgM) antibodies and a double immunocytochemical staining technique for simultaneous demonstration of the enzymes AP and HRP, we were able to determine both the antigen specificity (anti-TNP) and the (sub)class of intracellular antibodies produced by individual antibody-forming cells in vivo.

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15

Park, Ho Youn, Asode Ananthram Shetty, Jang Mook Kim, Young Ju Kim, Jae-Deog Jang, Nam Yong Choi, Jae Ho Lee y Seok Jung Kim. "Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate". Cells Tissues Organs 203, n.º 6 (2017): 339–52. http://dx.doi.org/10.1159/000455829.

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We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (E1) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group E1 progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing.

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Bánszegi, Oxana, Vilmos Altbäcker y Ágnes Bilkó. "Intrauterine position influences anatomy and behavior in domestic rabbits". Physiology & Behavior 98, n.º 3 (septiembre de 2009): 258–62. http://dx.doi.org/10.1016/j.physbeh.2009.05.016.

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Lipkin, W. I., P. L. Schwimmbeck y M. B. Oldstone. "Antibody to synthetic somatostatin-28(1-12): immunoreactivity with somatostatin in brain is dependent on orientation of immunizing peptide." Journal of Histochemistry & Cytochemistry 36, n.º 4 (abril de 1988): 447–51. http://dx.doi.org/10.1177/36.4.2450123.

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Rabbits were immunized with synthetic peptides representing the neurotransmitter dodecapeptide somatostatin-28(1-12) (SANSNPAMAPRE) coupled to the carrier protein keyhole limpet hemocyanin (KLH) at either the amino or the carboxyl terminus. Although all rabbits produced high-titer antisera to immunizing peptide, as assayed by ELISA, only rabbits immunized with peptide coupled to carrier at the amino terminus yielded antibodies that bound to native somatostatin in mouse brain slices. This effect of peptide coupling orientation on epitope specificity of peptide antisera is likely to be significant to other investigators who use predetermined peptide sequences to generate immunohistochemical reagents.

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Casey, Kerriann M., Felicity Gore, José G. Vilches-Moure, Masahiro Maruyama, Stuart B. Goodman, Yunzhi Peter Yang y Samuel W. Baker. "Management of Morbidity and Mortality in a New Zealand White Rabbit Model of SteroidInduced Osteonecrosis of the Femoral Head". Comparative Medicine 71, n.º 1 (1 de febrero de 2021): 86–98. http://dx.doi.org/10.30802/aalas-cm-20-000071.

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Steroid-induced osteonecrosis of the femoral head (SONFH) is a condition documented in humans and animals exposed to chronic steroid administration. The rabbit has become a preferred animal model for investigating the pathogenesis and treatment of SONFH due to its shared femoral vascular anatomy with human patients, relative size of the femoral head, and general fecundity. However, morbidity and mortality are frequent during the steroid induction period, prior to surgical manipulation. These problems are poorly reported and inadequately described in the literature. In this study, we report the clinical, gross, and histopathologic findings of New Zealand white (NZW) rabbits undergoing the steroid induction phase of the SONFH model. Severe weight loss (>30%), lipemia, hypercholesterolemia, hyperglycemia, and elevations in ALT and AST were consistent findings across all rabbits, although these changes did not differentiate asymptomatic rabbits from those that became clinically symptomatic or died. Euthanized and spontaneously deceased rabbits exhibited hepatomegaly, hepatic lipidosis/glycogenosis, and hepatocellular necrosis, in addition to a lipid-rich and proteinaceous thoracic effusion. A subset of rabbits developed opportunistic pulmonary infections with Bordetella bronchiseptica and Escherichia coli and small intestine infections with Lawsonia intracellularis superimposed on hepatic and thoracic disease. Together, these findings allowed us to establish a clinical decision-making flowchart that reduced morbidities and mortalities in a subsequent cohort of SONFH rabbits. Recognition of these model-associated morbidities is critical for providing optimal clinical care during the disease induction phase of SONFH.

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Wang, Hao-Hao, Yi-Xiang J. Wang, Hui Sheng, Ge Zhang, Ling Qin, Anil T. Ahuja y Li-Song Teng. "Fossa trochanterica of the proximal femur in rabbits: An anatomic structure for potential misinterpretation on magnetic resonance images". Acta Radiologica 50, n.º 2 (marzo de 2009): 212–16. http://dx.doi.org/10.1080/02841850802635208.

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Background: Magnetic resonance imaging (MRI) has been increasingly used as an investigational tool for assessing the structure and function of animal skeletal disease models. However, to date, MRI tomographic knowledge of laboratory animal skeletal anatomy and pathology remains limited. Purpose: To demonstrate that fossa trochanterica of the proximal femur in rabbits can potentially be misinterpreted as a bone lesion on MR images. Material and Methods: Twenty 28–30-week-old male New Zealand white rabbits were used in the study. Corticosteroid-induced osteonecrosis induction was carried out with a combined administration of lipopolysaccharide and methylprednisolone. In this animal model, it is known that osteonecrosis commonly occurs in the proximal femur. MRI at 1.5T was performed before osteonecrosis induction, and at 1 and 2 weeks post-osteonecrosis induction. For anatomical imaging of the proximal femur, coronal sectional images were obtained to align the femoral head, neck, and proximal shaft in a single plane. Volumetric computed tomography (CT) comprised continuous axial acquisitions through the bilateral hip joints and femurs and was performed on one age- and sex-matched New Zealand white rabbit to correlate MRI anatomical findings. Results: In 30% of the acquired normal data sets, a low-signal area surrounded by high-signal bone marrow was observed slightly distal to the femoral head and medial to the third trochanter. This dark, low-signal area resembled an osteonecrosis lesion on MR images. Volumetric CT clarified that the low MR signal was due to the deep fossa trochanterica structure in the rabbit proximal femur. Conclusion: Improved understanding of the cross-sectional anatomy of the fossa trochanterica in the rabbit proximal femur will prevent misinterpretation as a bone lesion on MR images.

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Berg, T., J. Sulner, C. Y. Lai y R. L. Soffer. "Immunohistochemical localization of two angiotensin I-converting isoenzymes in the reproductive tract of the male rabbit." Journal of Histochemistry & Cytochemistry 34, n.º 6 (junio de 1986): 753–60. http://dx.doi.org/10.1177/34.6.3009604.

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The male reproductive tract contains two different isoenzymes of angiotensin I-converting enzyme (ACE), i.e., pulmonary and testicular ACE. The present study shows selectively the cellular distribution of the ACE isoenzymes in the reproductive tract of male rabbit, using indirect immunofluorescence or immunoperoxidase methods. Testicular ACE was found in the seminiferous tubules of the testes in spermatocytes containing mature spermatids, and in spermatids within the epididymal tubular lumen in sexually mature, but not in immature, rabbits. Epididymal tubular cells contained pulmonary ACE. In the young rabbit, epididymal tissue contained more ACE than that in adult rabbit, since ACE was observed in principal cells in addition to basal cells. In mature rabbit, ACE was observed in basal cells only. Strong staining for pulmonary ACE was observed in cells of the vas deferens in both young and adult rabbit. Therefore, synthesis of epididymal ACE, unlike the testicular isoenzyme, was not stimulated by sexual maturation. Enzymatically active ACE in seminal fluid corresponds to the pulmonary isoenzyme. The present study indicates that this seminal fluid ACE may originate from cells of the epididymal tubules, particularly those of the vas deferens. Endothelial cells of blood vessels lying in the interstitium of both testicular and epididymal tissue contained the pulmonary isoenzyme.

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Claassen, E., L. T. Adler y F. L. Adler. "Double immunocytochemical staining for the in situ study of allotype distribution during an anti-trinitrophenyl immune response in chimeric rabbits." Journal of Histochemistry & Cytochemistry 34, n.º 8 (agosto de 1986): 989–94. http://dx.doi.org/10.1177/34.8.2426338.

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After incubation of tissue sections with anti-allotype-enzyme conjugates, the localization of immunoglobulin-allotype-bearing cells in the lymphoid tissues of conventional and chimeric rabbits could be established. The use of anti-allotype sera bearing distinct enzyme labels allowed simultaneous recognition of B cells producing immunoglobulin of one or the other parental types in heterozygous rabbits, or of B cells from the donor and recipient in chimeras. After immunization of chimeric rabbits with trinitrophenyl-keyhole limpet hemocyanin, anti-trinitrophenyl antibody-forming cells could be demonstrated through the use of a trinitrophenyl-alkaline phosphatase conjugate. Simultaneous incubation of sections with this reagent and with horseradish peroxidase coupled to (donor or recipient) anti-allotype sera made possible the determination of the origin (donor or recipient) of the antibody-forming cells. In agreement with the results of plaque assays and analyses of serum antibodies, all the anti-TNP producing cells were of donor origin when the chimeras had been created through injection of spleen or lymph node cells from trinitrophenyl primed donors. With this study we introduce a simple, direct method for the simultaneous identification of cells that produce antibody of a given allotype and a given specificity, applicable to appropriate studies in heterozygous or chimeric rabbits. The procedure has various advantages over previously reported methods.

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Kamaruzaman, Nurfatin Asyikhin, Egi Kardia, Nurulain ‘Atikah Kamaldin, Ahmad Zaeri Latahir y Badrul Hisham Yahaya. "The Rabbit as a Model for Studying Lung Disease and Stem Cell Therapy". BioMed Research International 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/691830.

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No single animal model can reproduce all of the human features of both acute and chronic lung diseases. However, the rabbit is a reliable model and clinically relevant facsimile of human disease. The similarities between rabbits and humans in terms of airway anatomy and responses to inflammatory mediators highlight the value of this species in the investigation of lung disease pathophysiology and in the development of therapeutic agents. The inflammatory responses shown by the rabbit model, especially in the case of asthma, are comparable with those that occur in humans. The allergic rabbit model has been used extensively in drug screening tests, and this model and humans appear to be sensitive to similar drugs. In addition, recent studies have shown that the rabbit serves as a good platform for cell delivery for the purpose of stem-cell-based therapy.

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Brandon, C. y M. H. Criswell. "Antiserum to lucifer yellow: preparation, characterization, and use for immunocytochemical localization of dye-filled retinal neurons." Journal of Histochemistry & Cytochemistry 39, n.º 11 (noviembre de 1991): 1547–53. http://dx.doi.org/10.1177/39.11.1918929.

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We present a new method for the preparation of antisera to Lucifer Yellow, and these antisera are here shown to be particularly suitable for immunocytochemical localization of multiple dye-injected cells in large pieces of vertebrate retina. The method involves the preparation of covalent conjugates of the VS isomer of Lucifer Yellow with keyhole limpet hemocyanin (KLH) or rabbit serum albumin (RSA), and their use as immunogens in rabbits. Both carrier protein conjugates yielded robust antibody responses. Antiserum to the KLH-LY conjugate contained precipitating antibodies against LY and KLH, although activity to the latter did not interfere with immunocytochemical staining. Rabbit antiserum to the RSA-LY conjugate contained precipitating antibody only against LY. When used for immunocytochemical staining of large retinal pieces containing many LY-filled cells, both antisera yielded well-stained, darkly filled cells similar to those seen with the Golgi technique; even very fine dendritic processes of retinal ganglion cells could be followed for long distances. LY immunocytochemistry provides a useful alternative to photooxidation for the analysis of multiple dye injected cells, especially in whole mounts. This approach may also be useful for immunocytochemical identification of cells filled with LY after tissue fixation.

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Kyllar, Michal, Barbora Putnová, Vladimír Jekl, Ladislav Stehlík, Marcela Buchtová y Jan Štembírek. "Diagnostic imaging modalities and surgical anatomy of the temporomandibular joint in rabbits". Laboratory Animals 52, n.º 1 (26 de abril de 2017): 38–50. http://dx.doi.org/10.1177/0023677217702178.

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The temporomandibular joint (TMJ) is a condylar synovial joint that, together with the masticatory muscles, controls mandibular movement during mastication. The rabbit is often used as a model species for studying the mechanisms of TMJ diseases, and in regenerative research. However, there are significant differences between rabbit and human TMJs that should be taken into account before using this model for experimental research. Here, we use several analytical approaches (radiography, computed tomography and magnetic resonance imaging) to enable a detailed description and analysis of the rabbit TMJ morphology. Moreover, possible surgical approaches have been introduced with a focus on available access into the rabbit TMJ cavity, which relate our findings to clinical usage.

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25

Ray, M. K., G. Wang, J. Barrish, M. J. Finegold y F. J. DeMayo. "Immunohistochemical localization of mouse Clara cell 10-KD protein using antibodies raised against the recombinant protein." Journal of Histochemistry & Cytochemistry 44, n.º 8 (agosto de 1996): 919–27. http://dx.doi.org/10.1177/44.8.8756763.

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To investigate the developmental regulation of the mouse Clara cell 10-KD protein (mCC10), we raised an antibody against the recombinant mCC10 protein. The coding region for the mature mCC10 protein was placed in frame with the glutathione-S-transferase gene in the pGEX2-T bacterial expression vector. The GST-mCC10 fusion protein was expressed in E. coli DH5 alpha cells. The fusion protein was purified and eluted using glutathione-Sepharose beads. The GST-mCC10 fusion protein was injected into rabbits to raise antibodies. The rabbit anti-mCC10 antibody was tested by immunoblot analysis using both purified protein as well as extracts of lung, liver, and uterus. The antibodies produced were used in immunohistochemistry and immunoelectron microscopy to detect the cellular localization of this protein in the above organs. This anti-mCC10 antibody will be useful for future investigation of the developmental biology of the lung.

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26

FURUTANI, Rui y Shoei SUGITA. "Projection from the Facial Nucleus to the Auricular Muscles of Rabbits". Okajimas Folia Anatomica Japonica 81, n.º 5 (2004): 109–18. http://dx.doi.org/10.2535/ofaj.81.109.

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27

Stahnke, T., S. Siewert, E. Walther, W. Schmidt, O. Stachs, K. P. Schmitz y R. F. Guthoff. "Adopting oculopressure tonometry as a transient in vivo rabbit glaucoma model". Current Directions in Biomedical Engineering 1, n.º 1 (1 de septiembre de 2015): 127–30. http://dx.doi.org/10.1515/cdbme-2015-0033.

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AbstractGlaucoma represents a group of eye disorders partly related to raised intraocular pressure (IOP) leading to progressive optic nerve damage resulting in impaired vision and possibly blindness. To assess the suitability of new IOP lowering therapeutic strategies, such as the implantation of glaucoma drainage devices, appropriate animal models have to be used. Currently, a number of rodent glaucoma models are available [1], however, especially for surgical interventions rodent eyes are too small. Rabbits are much more suitable with respect to dimension. Unfortunately, rabbit glaucoma model systems described in literature are difficult to reproduce or fail totally, associated with a high level of discomfort and pain for treated animals. Therefore, development of an in vivo rabbit glaucoma model is one of the most important goals in glaucoma research. Here, we describe the adaptation of the oculopressure tonometry, an existing method to quantify the outflow of aqueous humor in humans, to generate a transient glaucoma model in rabbits. The existing suction-cup oculopressor (SCOP) is extended with newly designed suction-cups, which are adjusted to the anatomy of the rabbit eye. The modification of the oculopressure tonometry method facilitates an increase in IOP over a time frame of 9 minutes by vacuum induced deformation of the rabbit eye. This method can be used to test functionality of fistulating glaucoma surgeries or implanted drainage devices in a long term follow-up without any side effects and suffering of the animals.

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28

Özkadif, Sema, Emrullah Eken y İbrahim Kalaycı. "A Three-Dimensional Reconstructive Study of Pelvic Cavity in the New Zealand Rabbit (Oryctolagus cuniculus)". Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/489854.

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The present study has been performed to reveal biometrical aspects and diameter-related differences in terms of sexes regarding pelvic cavity via three-dimensional (3D) reconstruction by using multidetector computed tomography (MDCT) images of pelvic cavity of the New Zealand rabbit. A total of 16 adult New Zealand rabbits, including 8 males and 8 females, were used in this study. Under anesthesia, the images obtained from MDCT were stacked and overlaid to reconstruct the 3D model of the pelvic cavity using 3D modeling software (Mimics 13.1). Measurements, such as the conjugate, transverse, and vertical diameters of the pelvic cavity, and the pelvic inclination were calculated and analyzed statistically. Biometrical differences of the pelvic diameters in New Zealand rabbits of both sexes were shown clearly. It was concluded that the pelvic diameters revealed by 3D modeling techniques can shed light on medical students who take both anatomy training and gynecological applications. The authors hope that the synchronization of medical approaches may give rise to novel diagnostic and therapeutic developments related to pelvic cavity.

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29

Bhimji, S., D. V. Godin y J. H. McNeill. "Myocardial Ultrastructural Changes in Alloxan-Induced Diabetes in Rabbits". Cells Tissues Organs 125, n.º 3 (1986): 195–200. http://dx.doi.org/10.1159/000146161.

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30

Chapeau, C., J. Gutkowska, P. W. Schiller, R. W. Milne, G. Thibault, R. Garcia, J. Genest y M. Cantin. "Localization of immunoreactive synthetic atrial natriuretic factor (ANF) in the heart of various animal species." Journal of Histochemistry & Cytochemistry 33, n.º 6 (junio de 1985): 541–50. http://dx.doi.org/10.1177/33.6.3158698.

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The localization of two synthetic fragments of the C-terminal portion of atrial natriuretic factor: Arg 101-Tyr 126 which displays full biological activity and Leu 94-Arg 109 which is completely devoid of biological activity, has been investigated by immunohisto- and immunocytochemical methods in the heart of mammals (rat, mouse, guinea pig, hamster, rabbit, cat, dog, man) and nonmammalian vertebrates toad (Bufo marinus), frog (Rana catesbeiana), fish (Cyprinus carpio, Puntius schwanenfeldi, Cichlosoma biocellatum, Carrasius auratus), snake (Python reticulatus) and hen. Antibodies against the synthetic fragments of ANF were raised in rabbits and used either for immunofluorescence (Coons' technique), immunohistochemistry (unlabeled antibody technique) or immunocytochemistry (protein A-gold technique). Results obtained by immunofluorescence and by the unlabeled antibody technique were similar: antibodies against Arg 101-Tyr 126 ANF allowed visualization of granulated cardiocytes in the atria of all mammals. While the reaction was very strong in rat and mouse, it was less so in the rabbit and very weak in all other species studied including man. Antibodies against Leu 94-Arg 109 ANF produced a reaction only in the rat and mouse. In nonmammalian vertebrates, the reaction was always much stronger in atria than ventricles of all species with both antibodies.

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31

Boffa, M. C., B. Burke y C. C. Haudenschild. "Preservation of thrombomodulin antigen on vascular and extravascular surfaces." Journal of Histochemistry & Cytochemistry 35, n.º 11 (noviembre de 1987): 1267–76. http://dx.doi.org/10.1177/35.11.2821107.

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The protein C anticoagulant system is mediated by thrombin and is highly accelerated by thrombomodulin. We studied the distribution of thrombomodulin antigen (TM Ag) in the rabbit using an affinity-purified antibody raised in a goat against rabbit thrombomodulin. The preservation of TM Ag was highly dependent on immediate fixation of the surface on which it is located. TM Ag was found on the endothelium of the entire vasculature, whereas it was absent from all connective tissue, smooth and striated muscle, secretory epithelia, cartilage, bone, neural tissue, and all parenchyma examined. A new finding was the presence of TM Ag on nonvascular surfaces of body cavities (the mesothelia of pleura, pericardium, and peritoneum, the synovial membrane, and the arachnoid enveloping the central nervous system). By use of a functional assay, TM activity was recovered in buffered saline/detergent solution which was either injected into the intraperitoneal cavity of rabbits in vivo or incubated with the surface of the arachnoid in vitro. These findings extend the importance of anticoagulant mechanisms to the systems of slowly circulating fluids, in which they might be required for maintenance of the flow, and to mesothelial cavities, in which they could be necessary for preventing adherence between the surfaces, in conditions associated with pathological exudation.

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32

Ferreira, F. D., R. Robinson, A. R. Hand y A. Bennick. "Differential expression of proline-rich proteins in rabbit salivary glands." Journal of Histochemistry & Cytochemistry 40, n.º 9 (septiembre de 1992): 1393–404. http://dx.doi.org/10.1177/40.9.1380529.

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Salivary glands synthesize and secrete an unusual family of proline-rich proteins (PRPs) that can be broadly divided into acidic and basic PRPs. We studied the tissue-specific expression of these proteins in rabbits, using antibodies to rabbit acidic and basic PRPs as well as antibodies and cDNA probes to human PRPs. By immunoblotting, in vitro translation, and Northern blotting, basic PRPs could be readily detected in the parotid gland but were absent in other salivary glands. In contrast, synthesis in vitro of acidic PRPs was detected in parotid, sublingual, and submandibular glands. Ultrastructural localization with immunogold showed heavy labeling with antibodies to acidic PRPs of secretory granules of parotid acinar cells and sublingual serous demilune cells. Less intense labeling occurred in the seromucous acinar cells of the submandibular gland. With antibodies to basic PRPs, the labeling of the parotid gland was similar to that observed with antibodies to acidic PRPs, but there was only weak labeling of granules of a few sublingual demilune cells, and no labeling of the submandibular gland. These results demonstrate a variable pattern of distribution of acidic and basic PRPs in rabbit salivary glands. These animals are therefore well suited for study of differential tissue expression of PRPs.

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33

Maeno, M., M. Taguchi, K. Kosuge, K. Otsuka y M. Takagi. "Nature and distribution of mineral-binding, keratan sulfate-containing glycoconjugates in rat and rabbit bone." Journal of Histochemistry & Cytochemistry 40, n.º 11 (noviembre de 1992): 1779–88. http://dx.doi.org/10.1177/40.11.1431063.

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The presence of keratan sulfate (KS) and KS proteoglycans in bone has been demonstrated in birds and rabbits but comparison with other animal species has not been investigated. The nature and distribution of mineral-binding, KS-containing glycoconjugates in rat and rabbit bone were investigated with a monoclonal antibody (MAb 5D4) specific for KS. Mineral-binding proteins were extracted from the mineralized bone with 0.4 M EDTA without guanidine-HCl (E-extract). On Western blot analysis of SDS-polyacrylamide gel electrophoresis, rat E-extract gave a weak 5D4-reactive band, M(r) 66,000-68,000, whereas rabbit E-extract produced two major reactive populations of small and large molecular size; one population consisted of two closely spaced bands at M(r) 61,000-63,000 and 66,000-68,000, and the other population consisted of one band at approximately M(r) 200,000. The identity of KS chains was further established by the sensitivity of these bands to keratanase II (Bacillus sp. Ks 36) and endo-beta-galactosidase. Immunocytochemistry with MAb 5D4 showed that, in rat bone, staining associated with the mineral phase was limited to the walls of osteocytic lacunae and bone canaliculi, whereas the remainder of the mineralized matrix lacked staining. In contrast, in rabbit bone the staining was distributed over the entire portion of the mineralized matrix with focal accumulation of staining in the wall of the lacunocanalicular system. These results indicate that rat bone contains a mineral-binding, KS-containing glycoconjugate with preferential localization in the wall of the lacunocanalicular system, whereas rabbit bone contains at least two or possibly three types of KS-containing glycoconjugates distributed over the entire portion of the mineralized matrix.

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34

Babler, William J., John A. Persing, Mathew J. Nagorsky y John A. Jane. "Restricted growth at the frontonasal suture: Alterations in craniofacial growth in rabbits". American Journal of Anatomy 178, n.º 1 (enero de 1987): 90–98. http://dx.doi.org/10.1002/aja.1001780112.

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35

Blumenau, L. V. "To the microscopic anatomy of the medulla oblongata". Neurology Bulletin VI, n.º 2 (29 de octubre de 2020): 119–32. http://dx.doi.org/10.17816/nb48647.

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In the course of several years since my employment in the laboratory, prof. S. Golgi (summer 1891) I repeatedly had to process the medulla oblongata of newborn animals (cats, dogs and rabbits and stillborn human fetuses) according to the method of the named anatomist. Thus, I have accumulated, and quite a lot, preparations of the medulla oblongata according to Golgi. Although recently there have been several wonderful studies of the same part of the brain and in the same way, I did not dare to use my material, in order to draw attention to some particulars, little or not touched upon by other authors.

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36

Valdivia Gandur, Iván, Victoria Tallón Walton, Patricia Carvalho Lobato, Vicente Lozano de Luaces y María Cristina Manzanares Céspedes. "Mandible Measurements and Dental Midline Deviation after Alveolar Nerve Transection in Growing Rabbits". International Journal of Morphology 29, n.º 1 (marzo de 2011): 52–56. http://dx.doi.org/10.4067/s0717-95022011000100008.

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37

Donnelly, Thomas M. y David Vella. "Anatomy, Physiology and Non-dental Disorders of the Mouth of Pet Rabbits". Veterinary Clinics of North America: Exotic Animal Practice 19, n.º 3 (septiembre de 2016): 737–56. http://dx.doi.org/10.1016/j.cvex.2016.04.004.

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38

Van Caelenberg, Annemie I., Lieve M. De Rycke, Katleen Hermans, Leen Verhaert, Henri J. van Bree y Ingrid M. Gielen. "Computed tomography and cross-sectional anatomy of the head in healthy rabbits". American Journal of Veterinary Research 71, n.º 3 (marzo de 2010): 293–303. http://dx.doi.org/10.2460/ajvr.71.3.293.

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39

Seiden, David, Malathi Srivatsan y Paraluman A. Navidad. "Changes in Myosin Isozyme Expression during Cardiac Hypertrophy in Hyperthyroid Rabbits". Cells Tissues Organs 135, n.º 3 (1989): 222–30. http://dx.doi.org/10.1159/000146758.

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40

Lin, Wei-Wen, Yu-Chun Lin, Ti-Yu Chang, Shu-Huai Tsai, Hon-Chun Ho, Ying-Tsung Chen y Vivian C. Yang. "Caveolin-1 Expression Is Associated with Plaque Formation in Hypercholesterolemic Rabbits". Journal of Histochemistry & Cytochemistry 54, n.º 8 (17 de abril de 2006): 897–904. http://dx.doi.org/10.1369/jhc.5a6869.2006.

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41

Oliver, C. y Y. Yuasa. "Distribution of basal lysosomes in exocrine acinar cells." Journal of Histochemistry & Cytochemistry 35, n.º 5 (mayo de 1987): 565–70. http://dx.doi.org/10.1177/35.5.3031155.

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We examined the distribution of trimetaphosphatase (TMPase)-positive basal lysosomes in pancreas, parotid, submandibular, sublingual, and exorbital lacrimal glands from rats, rabbits, and guinea pigs. The location of the basal lysosomes was compared to that of the acid phosphatase (AcPase)-positive lysosomes. In all of the tissues examined from rat and rabbit, AcPase activity was localized primarily to the Golgi region. Reaction product was localized in GERL, immature secretory granules, and lysosomes lying adjacent to the Golgi apparatus. TMPase activity was found in basal lysosomes and in occasional elongated lysosomes adjacent to the Golgi apparatus. In guinea pig, the distribution of TMPase activity was identical to that seen in the other two species, but a significant number of lysosomes in the basal region of the cells also contained AcPase activity. These results confirm and extend our previous finding (J Histochem Cytochem 31:1209, 1983) that exocrine acinar cells possess two distinct populations of lysosomes. The lysosomes in the Golgi region contain both AcPase and TMPase activity, whereas those in the basal portion of the cells are reactive predominantly for TMPase. The functional significance of the two populations of lysosomes is not understood at present.

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42

Lyu, Linwei, Ye Jing, Jikun Wang y Chunqiu Zhang. "Enhanced Osseointegration of Porous Titanium Scaffold Implanted with Preload: An Experiment Study in Rabbits". International Journal of Morphology 38, n.º 4 (agosto de 2020): 909–13. http://dx.doi.org/10.4067/s0717-95022020000400909.

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43

Sarphie, T. G. "Anionic surface properties of aortic and mitral valve endothelium from New Zealand white rabbits". American Journal of Anatomy 174, n.º 2 (octubre de 1985): 145–60. http://dx.doi.org/10.1002/aja.1001740205.

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44

Alberius, Per y Per-Erik Isberg. "The correlation between craniofacial and long bone growth: An experimental investigation in normal rabbits". American Journal of Anatomy 177, n.º 4 (diciembre de 1986): 519–25. http://dx.doi.org/10.1002/aja.1001770410.

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45

Franklin, Reginaldo, Rodrigo Freitas Monte Bispo, Célio Fernando Sousa-Rodrigues, Lucas Alves Sarmento Pires, Albino Fonseca Jr. y Marcio Antonio Babinski. "Grape Leucoanthocyanidin Protects Liver Tissue in Albino Rabbits with Nonalcoholic Hepatic Steatosis". Cells Tissues Organs 205, n.º 3 (2018): 129–36. http://dx.doi.org/10.1159/000489166.

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Nonalcoholic fatty liver disease (NAFLD) is a common ailment. It is usually found in association with diabetes or obesity. There are no approved drugs to treat this condition. The study of flavonoid consumption has increased over the decades due to their antioxidative properties, although the literature is scarce when it comes to their effects in liver tissue. The purpose of this study was to evaluate the role of leucoanthocyanidin in nonalcoholic hepatic steatosis. Thirty male albino rabbits were divided in 3 groups. Group 1 had a regular commercial diet. The second group had a regular diet and 10 mL of egg yolk and 1.5 g of pure cholesterol. The rabbits of the third group were on the same regimen as the second, but were also treated with grape leucoanthocyanidin (50 mg/kg/day) for 100 days. On the last day of the experiment, the animals were euthanized, and the livers excised and fixated in a 10% formalin solution. Afterwards, fragments of each liver were removed and histologically processed and analyzed. The stereological evaluation showed that leucoanthocyanidin reduced NAFLD in comparison with the nontreated group. This was also observed in the histological analysis of the liver tissue, as the treated group had less foci of fatty tissue. Leucoanthocyanidin may therefore be a promising substance to treat NAFLD, although further studies are needed.

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46

Aminlari, Ladan, Maryam Tavana y Nasrin Kazemipour. "Rhodanese distribution in different tissues of rabbits". Comparative Clinical Pathology 23, n.º 5 (19 de junio de 2013): 1259–62. http://dx.doi.org/10.1007/s00580-013-1772-y.

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47

Goralskyi, L. P., N. M. Glukhova, I. M. Sokulskyi y N. V. Demus. "Features of the macro and microscopic structure of the lungs of a mature rabbit – Oryctolagus cuniculus L. 1758". Ukrainian Journal of Veterinary and Agricultural Sciences 4, n.º 1 (1 de marzo de 2021): 39–44. http://dx.doi.org/10.32718/ujvas4-1.08.

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The macro- and microscopic structure of the lungs of mature rabbits – Oryctolagus cuniculus L., 1758 – European rabbit was studied. This work was performed using comprehensive research methods: anatomical, organometric, histological and histometric. The research was carried out in the conditions of the laboratory of pathomorphology in the Department of Anatomy and Histology. The scientific work was performed on the subject of research work of the Department of Anatomy and Histology of Polissya National University on the theme: “Development, morphology and histochemistry of animal organs in normal and pathological”, according to the state registration number – № 0113V000900. The morphological studies followed the basic rules of Good Laboratory Practice GLP (1981), the provisions of the “General Ethical Principles of Animal Experiments”, adopted by the First National Congress of Bioethics (Kyiv, 2001) and the requirements for the “Rules for carrying out work with experimental animals”, approved by the order of the Ministry of Health № 281 of November 1, 2000 “On measures to further improve the organizational forms of work with the use of experimental animals”. The material for histomorphological studies were pieces of lungs selected from clinically healthy adult rabbits (n = 5). Slices were made from paraffin blocks on a sled microtome MS–2. The thickness of histological sections did not exceed 8–12 μm, which were then stained with hematoxylin and eosin and Van Gizon to study the morphofunctional activity of cells and tissues of the respiratory tract. Histometric studies of histological specimens were performed using a microscope “Micros” with a digital camera at a magnification of × 100–1000. Studies have shown that macroscopically the lungs of mature rabbits have a reflection of the shape of the thoracic cavity, and gradually expands ventrally. The right and left lungs are surrounded by pleural right and left sacs. The pleural cavities of both lungs in the test animals are not interconnected. Organometry showed that the absolute lung mass of rabbits is 18.05 ± 1.32 g, relative to 0.624 ± 0.013 %. The histoarchitectonics of the lungs is formed by the lung lobes. The respiratory department of the lungs is represented by a set of acinuses. The latter are represented by respiratory bronchioles, alveolar passages, alveolar sacs and alveoli that form the alveolar tree. The results of morphometric studies showed that the respiratory (respiratory) part of the lungs of rabbits occupies 39.6 ± 0.62 %, and the connective tissue base, respectively, 58.5 ± 1.27 %. The average volume of alveoli, which are divided into small, medium and large, is 42.3 ± 4.35 thousand μm3. Thus, studies of the macro- and microscopic structure of the lungs of experimental animals are of great general biological importance, as they are an important criterion for objective assessment for the differential diagnosis of diseases of various origins.

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48

Viamontes, G. I., T. K. Audhya, U. Babu y G. Goldstein. "Immunohistochemical localization of bursin in epithelial cells of the avian bursa of Fabricius." Journal of Histochemistry & Cytochemistry 37, n.º 6 (junio de 1989): 793–99. http://dx.doi.org/10.1177/37.6.2470807.

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Antibodies to the avian B-cell-differentiating hormone bursin (lysyl-histidyl-glycine amide) were raised in mice and rabbits by immunizing with bursin conjugates in Freund's adjuvant. Immunohistochemical staining with these bursin-specific antibodies was restricted to follicular and dendritic reticular epithelial cells of the bursa of Fabricius, and was not found in control avian tissues.

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49

Popoff, Steven N. y Sandy C. Marks. "Congenitally osteosclerotic (os/os) rabbits are not cured by bone marrow transplantation from normal littermates". American Journal of Anatomy 192, n.º 3 (noviembre de 1991): 274–80. http://dx.doi.org/10.1002/aja.1001920307.

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50

Mori, Naoki, Mitsuaki Yoshizuka, Hiroshi Ueda, Eizo Ono, Yuichi Umezu y Sunao Fujimoto. "Ultrastructural Findings in the Wound Healing of the Colonic Mucosa of Rabbits". Cells Tissues Organs 134, n.º 1 (1989): 82–88. http://dx.doi.org/10.1159/000146739.

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