Artículos de revistas: "Qian Yuan"

1

Liu, Ying. "The Model Research for Optimal Water Allocation of Irrigation Canal System". Applied Mechanics and Materials 256-259 (diciembre de 2012): 2494–97. http://dx.doi.org/10.4028/www.scientific.net/amm.256-259.2494.

Texto completo

Resumen

The present study make a deep analysis of the Chang TAN, Wu Yin, Tongshan Yuan,Wen Rui,Niu Tou mountain , Qian Tang River six large scale irrigation management status and conventional water distribution operation mode. We refer a promising method of optimal water allocation of irrigation canal system based on the former research.

Los estilos APA, Harvard, Vancouver, ISO, etc.

2

Cho, Bok Hyeon. "The Marriage of Li Yuan-hao of Xi-xia and Khitan Princess Xing Ping the War between Khitan and Xi-xia". Institute of History and Culture Hankuk University of Foreign Studies 84 (30 de noviembre de 2022): 187–216. http://dx.doi.org/10.18347/hufshis.2022.84.187.

Texto completo

Resumen

Xixia and Khitan maintained friendly relations between the two countries through their marriage to Li Ji Qian and princess Yi Cheng. And secondly, Li Yuan-hao and princess Xing Ping could be married. Although Li Yuan-hao was an outstanding monarch who founded the country, he also had a side to the immoral tyrant.Li Yuan-hao married Khitan princess Xing Ping. But She died of illness seven years after her marriage, and Khitan did not visit her when she died. Later, when Khitan's envoy asked the cause of the princess's death, he gave no answer, which angered the Khitan emperor. Xixia had strong dissatisfaction with Khitan's coercive attitude and financial problems. Khitan was angered by Li Yuan-hao's arrogant attitude, the death of Princess, and the attribution of the Dang Xiang tribe, which eventually led to war. It began in 1044 when Xing-zong of Liao Dynasty advanced in three directions with 176,000 soldiers. In the early days of the war, Khitan prevailed, but as Li Yuan-hao retreated, he gained victory by using tactics to eliminate the horse's prey and fatigue the soldiers. When Li Yuan-hao died in 1049 and Yizong, who was only one year old, ascended to the throne, Xingzong of Liao Dynasty started another war. Although Xixia surrendered and Khitan won, the relationship between the two countries was not as good as it used to be, and Khitan refused when Xixia proposed marriage again. From this point of view, it can be seen that the marriage of Li Yuan-hao and Princess Xing Ping eventually had a negative impact on the relationship between the two countries.

Los estilos APA, Harvard, Vancouver, ISO, etc.

3

Chiang, Sing-chen Lydia. "Visions of Happiness: Daoist Utopias and Grotto Paradises in Early and Medieval Chinese Tales". Utopian Studies 20, n.º 1 (1 de enero de 2009): 97–120. http://dx.doi.org/10.2307/20719931.

Texto completo

Resumen

Abstract This study traces the respective evolutions of two separate motifs—Daoist utopia and grotto heavens (dongtian)—in early and medieval Chinese literature, and discusses the significance of their convergence in the influential literary classic “Peach Blossom Spring” ("Taohua yuan ji") by Tao Qian (aka Tao Yuanming, 365—427). The purposes of this article are twofold: first, to enhance our understanding of the ideological and textual connections between “Peach Blossom Spring” and Confucianism and Daoism; second, to offer new insights into the unique characteristics of Chinese utopianism, where political vision and mythical imagination frequently were inter-twined.

Los estilos APA, Harvard, Vancouver, ISO, etc.

4

Chiang, Sing-chen Lydia. "Visions of Happiness: Daoist Utopias and Grotto Paradises in Early and Medieval Chinese Tales". Utopian Studies 20, n.º 1 (1 de enero de 2009): 97–120. http://dx.doi.org/10.5325/utopianstudies.20.1.0097.

Texto completo

Resumen

Abstract This study traces the respective evolutions of two separate motifs—Daoist utopia and grotto heavens (dongtian)—in early and medieval Chinese literature, and discusses the significance of their convergence in the influential literary classic “Peach Blossom Spring” ("Taohua yuan ji") by Tao Qian (aka Tao Yuanming, 365—427). The purposes of this article are twofold: first, to enhance our understanding of the ideological and textual connections between “Peach Blossom Spring” and Confucianism and Daoism; second, to offer new insights into the unique characteristics of Chinese utopianism, where political vision and mythical imagination frequently were inter-twined.

Los estilos APA, Harvard, Vancouver, ISO, etc.

5

Khan, Eid Muhammad, Muhammad Kamran y Fahad Jaber Alatawi. "A new species and new records of Tetranychidae (Acari: Trombidiformes) from Saudi Arabia, with a key to world species of Mixonychus Ryke and Meyer". Acarologia 59, n.º 4 (18 de noviembre de 2019): 492–506. http://dx.doi.org/10.24349/acarologia/20194349.

Texto completo

Resumen

The spider mite genus Neotetranychus Trägårdh is reported for the first time from Saudi Arabia (SA) based on N. longisetus n. sp., collected from Heliotropium arbainense (Boraginaceae). The new species is described and illustrated from the adult female, and three species, Mixonychus (Bakerina) aculus (Chaudhri), Paraplonobia (Anaplonobia) harteni (Meyer) and Sonotetranychus daleae (Tuttle and Baker) (Acari: Tetranychidae) are reported as new to the mite fauna of SA. Mixonychus (B.) aculus (Chaudhri) is re-described and illustrated based on adult female, collected from an exotic mesquite species from Mexico and Caribbean, Prosopis juliflora (Sw.) DC. (Fabaceae). Moreover, the species, Evertella orissaensis (Prasad) n. comb., is moved from the genus Mixonychus Ryke and Meyer to the genus Evertella Meyer and Mixonychus (Bakerina) ganjuis (Qian, Yuan and Ma) n. comb., is moved to the subgenus Bakerina Chaudhri from the subgenus Mixonychus. A key to the world species of the genus Mixonychus is also provided. Additionally, legs chaetotaxy of all known species of the genus Mixonychus is given.

Los estilos APA, Harvard, Vancouver, ISO, etc.

6

Ronan, Colin. "Wen-Yuan Qian. The Great Inertia. London: Croom Helm, 1984. Pp. xii + 155. ISBN 0-7099-2104-7. £15.95." British Journal for the History of Science 19, n.º 3 (noviembre de 1986): 370–71. http://dx.doi.org/10.1017/s0007087400023645.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

7

Yuan, Yanping, Cheng Qian, Chuanzhi Yangmeng, Li Fang y Ruiqing Yan. "Abstract 5130: Multi-plex cytokine profiling for mice on Bleomycin induced systemic sclerosis model". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 5130. http://dx.doi.org/10.1158/1538-7445.am2023-5130.

Texto completo

Resumen

Abstract Systemic sclerosis (SSc) is recognized as an autoimmune disorder characterized by immune dysregulation, obliterative vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other organs. It also ranks on the highest position of disease-related mortality and morbidity with an impaired quality of life among the rheumatologic illnesses. However, the immunological mechanism related to SSc remains to be elucidated systemically, which may lay for the novel therapeutic methodology. In the present study, we combined the MSD methodology and flow cytometry to landscape the chemokine or cytokine network, immunology response and signaling axis in mice on Blomycin induced SSc model. Our results provide the reference and path for the future direction of novel therapeutic reagents discovery. Citation Format: Yanping Yuan, Cheng Qian, Chuanzhi Yangmeng, Li Fang, Ruiqing Yan. Multi-plex cytokine profiling for mice on Bleomycin induced systemic sclerosis model. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5130.

Los estilos APA, Harvard, Vancouver, ISO, etc.

8

趙厚均, 趙厚均. "乾嘉閨秀的才名意識與文化轉型：以駱綺蘭為中心". 中正漢學研究 32, n.º 32 (diciembre de 2018): 143–60. http://dx.doi.org/10.53106/2306036020181200320006.

Texto completo

Resumen

經過明末清初的才德之辨，閨秀文學發展到乾嘉時期，進入了一個新的階段。此期的閨秀有著更強的才名意識，她們充分運用文壇領袖所掌握的文化權力，通過拜師等舉措拓展交往空間，從而與著名文人唱和、題贈，躋身文壇，顯揚聲名。駱綺蘭通過結交袁枚、王文治和王昶等，以畫作、詩集遍求題贈，並編選《聽秋軒贈言》和《聽秋軒閨中同人集》，得以聲名鵲起；歸懋儀在乾嘉文人與閨秀之間構築了一個非常龐大的交游網絡，她執著於詩史留名的願望，成功藉助男性文人的資助，令詩稿付梓，並憑藉才名遊走於江浙間擔任閨塾師，承擔起養家的重任；汪端則欲通過選詩修史來達到不朽，其《元明逸史》的撰寫和詩集中大量的詠史詩，可見其修史的努力，編選《明三十家詩選》更見其不凡的識見。吳藻創作雜劇《喬影》，並繪《飲酒讀騷圖》，體現出懷才不遇的苦悶和強烈的性別意識。總體而言，乾嘉閨秀已經不滿足于內闈狹小的空間，做出了跨越閨門的種種努力，是晚清民國閨秀文化近代轉型的先聲。  Following the debates on female talent during the late Ming and early Qing eras, women’s literary production entered a new stage. Women poets who were active during the Qian-Jia reigns had a stronger sense of establishing their literary fame through making use of the cultural power held by the leading poets of their time. They became the female disciples of these leading figures, and expanded their networks by communicating and exchanging poetic works with larger communities of eminent literati. Luo Qilan, in particular, succeeded in achieving fame through her important connections, including Yuan Mei, Wang Wenzhi, and Wang Chang. She broadly solicited inscriptions for her paintings and collections of poetry, and published The Collection of Inscriptions for the Autumn Pavilion and The Anthology of Poetic Works by Friends of the Autumn Pavilion. Gui Maoyi, another well-connected woman poet, built a literary community that included both male and female poets. She obtained help from the male literati to publish her poetry collection, thereby realizing her ambition of establishing an undying literary reputation. At the same time, she turned her poetic talent into a means of providing for her family, travelling all over Jiangsu and Zhejiang provinces to teach in elite families. Other well-known examples included Wang Duan and Wu Zao. Wang revealed her ambition of authoring history in a broad array of works, including An Informal History of the Yuan and the Ming, Selected Works by Thirty Ming Poets, and numerous poetic works on historical events. Wu was best known for her variety play, A Shadow in Disguise, as well as for her painting, “Drinking Wine and Reading the Sorrow of Departure.” In these works Wu lamented her unfulfilled ambitions and the limitations of gender roles. In general, women poets of this time made all kinds of efforts to venture beyond the inner quarters and can be viewed as the pioneer of the modern transformation of women’s writing culture during the late Qing and early Republican era.

Los estilos APA, Harvard, Vancouver, ISO, etc.

9

Cartier, Michel. "Wen-yuan Qian, The Great Inertia : Scientific Stagnation in Traditional China, Londres-Sydney-Dover-New Hampshire, Croom Helm, 1984, XII + 155 p." Annales. Histoire, Sciences Sociales 40, n.º 4 (agosto de 1985): 957–58. http://dx.doi.org/10.1017/s0395264900084432.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

10

Schimmelpfennig, Michael. "The Quest for a Classic: Wang Yi and the Exegetical Prehistory of his Commentary to the Songs of Chu". Early China 29 (2004): 111–62. http://dx.doi.org/10.1017/s0362502800007100.

Texto completo

Resumen

With the publication of Madman of Chu: A Myth of Loyalty and Dissent in 1980, Laurence Schneider established the view that the controversy over Qu Yuan between various erudites during the Han dynasty was a dispute between adherents and opponents about the question of what the Chu minister and poet stood for. The present study challenges this view by demonstrating that, aside from the so-called biographies by Sima Qian and Liu Xiang, all other contributions to the debate represent readings of the Li sao. Once this is understood, each contribution to the debate can not only be seen in its own light but it can also be examined in its relation to the section and sentence commentary by Wang Yi written in the second century C.E. The understanding of the controversy as a discourse of rather varied interpretations of the Li sao enables us to regard the Chuci zhangju by Wang Yi as a commentary that stood at the end of this controversy that lasted more than three centuries. It also enables us to see that the controversy rested on a particular set of premises, especially the question of the literary status of the Li sao and its author. The final thesis resulting from the present study is that the main reason for the lasting influence of Wang Yi's commentary together with the fact that it remained unchallenged until the twelfth century is that it was built on a sound and varied exegetical foundation, namely the controversy on the Li sao during the Han.The first part of this article examines the contributions to the controversy by Jia Yi (201–165), Liu An (?178–122), Sima Qian (145–?86), Liu Xiang (79–8), Yang Xiong (53 B.C.E-18 C.E.), Liang Song (?–83 C.E.) and Ban Gu (32–92) in chronological order. The second part juxtaposes their works with the commentary of Wang Yi in order to understand how the Eastern Han commentator employed the contributions of his predecessors and how he reacted to them.

Los estilos APA, Harvard, Vancouver, ISO, etc.

11

Zhao, Xiao Hong, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kai Hong Ye, Yuan Yuan Zhang, Liu Teng et al. "Abstract 7052: p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer". Cancer Research 84, n.º 6_Supplement (22 de marzo de 2024): 7052. http://dx.doi.org/10.1158/1538-7445.am2024-7052.

Texto completo

Resumen

Abstract The use of mitochondrial inhibitors to target oxidative phosphorylation (OXPHOS) in cancer treatment presents a challenge due to dose-limiting toxicities. Moreover, while glycolysis-deficient cancers are vulnerable to OXPHOS inhibition in preclinical models, the full extent of phenotypical and mechanistic consequences of inhibiting OXPHOS in cancers capable of glycolysis is not yet well understood. Our results presented here offer promising insights into potential therapeutic gains from combining p53 restoration strategies with OXPHOS inhibitors, even when applied to glycolysis-competent CRC cells. Treatment with mitochondrial complex I inhibitors did not cause energy stress in CRC cells capable of glycolysis. It does, however, induce DNA replication stress, apparent through an observed cell cycle arrest at the S phase, enrichment of the G2/M DNA-damage checkpoint regulation pathway, and replication fork slowdown. Intriguingly, CRC cells harboring wildtype p53 exhibited more severe replication stress than those carrying mutant p53. Furthermore, siRNA knockdown of p53 attenuates replication stress and reduces cell cycle arrest, underlining the important role of p53 in CRC cell responses to OXPHOS inhibition. Our targeted metabolomics analysis reveals that OXPHOS inhibition results in reductions in the purine nucleotides, adenine monophosphate (AMP) and guanine monophosphate (GMP), as well as the pyrimidine nucleotide, uridine monophosphate (UMP), in CRC cells, regardless of their p53 mutational status. By supplementing cell culture mediums with the purine nucleobases adenine and guanine, and the pyrimidine nucleoside uridine, we observed a partial reversal of the replication fork slowdown and reductions in cell viability. This suggests nucleotide deficiencies are involved in the induction of DNA replication stress caused by OXPHOS inhibition. The nucleotide deficiencies were associated with a decrease in the nucleobase precursor aspartate. By adding aspartate at a supraphysiological concentration, to overcome the low expression of the excitatory amino acid transporter 1 required for cellular import of aspartate, we were able to restore the levels of nucleotides. Collectively, our findings suggest broader potential cancer treatment paradigms via OXPHOS targeting, extending beyond glycolysis-deficient cancers. Our data uncovers that CRC cells, which commonly exhibit the glycolytic phenotype, are susceptible to OXPHOS inhibition, with those carrying wildtype p53 showing heightened sensitivity. Therefore, p53 status could serve as a biomarker for predicting CRC responses to OXPHOS inhibitors. Moreover, our findings suggest that combined strategies of restoring p53 function, using small molecules such as APR-246, might enable reduced dosage of OXPHOS inhibitors in CRC treatment, thereby mitigating their dose-limiting toxicities. Citation Format: Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kai Hong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Tao Liu, Mark Baker, Rick F. Thorne, Xu Dong Zhang, Song Chen, Lei Jin. p53 underpins a dependence on oxidative phosphorylation in glycolysis-competent colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7052.

Los estilos APA, Harvard, Vancouver, ISO, etc.

12

Han, Jaehee, Soonil Hwang, Hyebin Lee y Jens Braarvig. "Further Reflections on Zhi Qian’s Foshuo Pusa Benye Jing: Some Terminological Questions". Religions 12, n.º 8 (11 de agosto de 2021): 634. http://dx.doi.org/10.3390/rel12080634.

Texto completo

Resumen

Zhi Qian (支謙, fl. ca. 220–257 CE), a prolific Yuezhi-Chinese translator of Indian Buddhist scriptures into Chinese, is widely known for his broad range of styles and terminology. For several decades, his translation activities and his legacy in the history of Chinese Buddhist literature have been a rich field of research, particularly within the context of the transmission of Buddhism from India to China. In the present article, as a follow-up study to “Buddhism for Chinese readers: Zhi Qian’s Literary Refinements in the Foshuo pusa benye jing,” recently published by the authors in this journal, we offer additional reflections on distinctive features of Zhi Qian’s language. We focus on four unusual and interesting renderings in the Foshuo pusa benye jing (佛說菩薩本業經, T. 281), namely (1) santu 三塗; (2) shezui 捨罪; (3) kong 空, wu xiang 無想 and bu yuan 不願; and (4) sishi buhu 四時不護. Through an analysis of these words and phrases, we discuss Zhi Qian’s translation techniques and lexical idiosyncrasies, highlighting their significance in our understanding of the dynamics of language contact and change in the early period of the Chinese Buddhist tradition. Thus, the paper investigates some key Buddhist terms as coined by the early translators on the basis of the classical Chinese and illustrates the semantic changes of the Chinese language taking place in the period as well as influence of Buddhist regimes of knowledge.

Los estilos APA, Harvard, Vancouver, ISO, etc.

13

李美燕, 李美燕. "莊臻鳳〈蝶庵琴聲十六法〉對徐谼〈谿山琴況〉之承襲與轉化". 藝術評論 44, n.º 44 (enero de 2023): 001–36. http://dx.doi.org/10.53106/101562402023010044001.

Texto completo

Resumen

明末清初以來的古琴曲譜中保留有兩篇重要的音樂美學著作，一是徐谼的〈谿山琴況〉（收錄於《大還閣琴譜》），乃中國古琴音樂美學的顛峰之作，其以二十四況論述彈琴的演奏技巧及美感意境論，通篇是儒、道、佛思想調和的作品，體現著琴以載道的教化精神。二是莊臻鳳的〈蝶庵琴聲十六法〉（收錄於《琴學心聲諧譜》），這兩篇論著皆是以「一字評」的方式作為品評琴樂之美的範疇，同為中國古琴音樂美學的並蒂之作。然而，〈蝶庵琴聲十六法〉的內容有不少篇幅與〈谿山琴況〉雷同，兩者之說究竟孰前孰後？因此，關於〈蝶庵琴聲十六法〉的作者與版本的考異也就成為一個值得探討的問題。前人或以為〈蝶庵琴聲十六法〉的作者是元末明初的冷謙，或以為是清初的莊臻鳳，頗有爭議，故本文先釐清其中的疑義，再看〈蝶庵琴聲十六法〉除了對〈谿山琴況〉有所承襲外，其不同於〈谿山琴況〉的觀點為何？由此來給予〈蝶庵琴聲十六法〉在琴學中的定位。  Two key works on the aesthetics of Chinese guqin music have been preserved in the Guqin tablatures of the late Ming and early Qing dynasties. One work is ‟Xishan Qin kwuan”（24 Epithets on Guqin Music) collected in Dahuange Qinpu (Qin Handbook from the Chamber of Great Returning) written by Xu Hong. It is the pinnacle of Chinese Guqin musical aesthetics, discussing Guqin playing skills and aesthetic conception in twenty-four aspects. Although the details of the twenty-four aspects differ, the whole article is a harmonious amalgamation of Confucianism, Taoism, and Buddhism, which embodies the enlightenment spirit of Tao. The other work is ‟Diean Sixteen Rules for the Tones of Qin” collected in Qinxue Xinsheng Xiepu (Qin Studies Heartfelt Sounds Harmonious Tablature), written by Zhuang Zhenfeng. Both of these works are based on the “one-character review” as the criterion for appraising the beauty of Guqin music. However, there is a lot of overlap in the content of these two works, which raises the question of which one was written first. This paper discusses the ‟Sixteen Rules for the Tones of Qin” and its author, focusing on two key considerations: First, who is the real author of the ‟Sixteen Rules for the Tones of Qin” -- Leng Qian in the late Yuan and early Ming dynasty, or Zhuang Zhenfeng in the early Qing dynasty? Second, the research compares and contrasts ‟Sixteen Rules for the Tones of Qin” with ‟Xishan Qin kwuan” and reveals how the guqin aesthetics of the former were inherited and changed after the publication of the latter. Following on from this, the author discusses the true authorship of ‟Sixteen Rules for the Tones of Qin” and its inheritance and evolution from ‟Xishan Qin kwuan” (24 Epithets on Guqin Music).

Los estilos APA, Harvard, Vancouver, ISO, etc.

14

Zhou, W., M. He, R. Zhao, C. Dong y Z. Gu. "AB1331-HPR ACTIVE DISEASE ACTIVITY IN ANKYLOSIS SPONDYLITIS: WORSE OUTCOMES AND POORER HR-QOL". Annals of the Rheumatic Diseases 79, Suppl 1 (junio de 2020): 1954.2–1954. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6288.

Texto completo

Resumen

Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joints and the spine, resulting in decline in quality of life[1,2]. Poor QoL is significantly related to high disease activity[3]. However, there is no systematic report on which prognosis indicators are affected by disease activity in AS patients.Objectives:This study aimed to evaluate the patient-reported outcome measures and health-related quality of life (HR-QoL) in AS patients defined on the basis of the Bath Spondylitis Ankylosing Disease Activity Index (BASDAI).Methods:204 AS patients were involved in this study. A serious of questionnaires were used to overall assess AS patients, which include: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), the 10 cm Visual Analog Scale (VAS), the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), the Pittsburgh Sleep Quality Index (PSQI), the Health Assessment Questionnaire-Disability Index (HAQ-DI), the Fatigue Severity Scale(FSS) and the Short Form 36 Health Survey (SF-36). Independent samples t-test, Mann–Whitney U-test, Chi-square analysis and Pearson /Spearman correlation were used to analyze the data.Results:The results demonstrated 31.4% AS patients were in active disease activity stage. Active AS patients were older, unemployed, and had less exercise therapy than stable AS patients. Besides, AS patients with active disease activity presented more severe pain(P<0.001), poor physical function(P<0.001) and spinal mobility(P<0.001). They were more anxious(P<0.001), depressed(P<0.001) and had more sleep disturbance(P=0.001). Compared with active AS patients, stable AS patients had more leukocytes(P=0.040), lymphocytes(P=0.002), erythrocytes(P=0.001) and hemoglobin(P<0.001). Active disease activity had a significant impact on all dimensions of quality of life in AS patients(P<0.001).Conclusion:These findings suggested that medical personnel should pay more attention to active AS patients and make effective interventions to improve quality of life.References:[1]Exarchou S, Lindstrom U, Askling J, Eriksson JK, Forsblad-d’Elia H, Neovius M, Turesson C, Kristensen LE, Jacobsson LT (2015) The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study. Arthritis research & therapy 17:118. doi:10.1186/s13075-015-0627-0[2]Qian Q, Xu X, He H, Ji H, Zhang H, Ding Y, Dai SM, Zou Y, Zhu Q, Yang C, Ye S, Jiang L, Tang JP, Tong Q, He D, Zhao D, Li Y, Ma Y, Zhou J, Yuan Z, Zhang J, Jin L, Zhou X, Reveille JD, Zou H, Wang J (2017) Clinical patterns and characteristics of ankylosing spondylitis in China. Clinical rheumatology 36 (7):1561-1568. doi:10.1007/s10067-017-3660-3[3]Huang JC, Qian BP, Qiu Y, Wang B, Yu Y, Zhu ZZ, Hu J, Qu Z (2017) Quality of life and correlation with clinical and radiographic variables in patients with ankylosing spondylitis: a retrospective case series study. BMC musculoskeletal disorders 18 (1):352. doi:10.1186/s12891-017-1711-1Acknowledgments:Thanks to all the authors for their efforts and thanks to all members of the Department of Rheumatology of Affiliated Hospital of Nantong University for their helpfulness in the acquisition of data.Disclosure of Interests:None declared

Los estilos APA, Harvard, Vancouver, ISO, etc.

15

Zhu, Fang, Hongyan Sun, Qian Lu, Yuan Fang, Jianming Xu, Cunxiang Ju, Hongyu Wang et al. "Abstract 3242: Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 3242. http://dx.doi.org/10.1158/1538-7445.am2023-3242.

Texto completo

Resumen

Abstract Antibody-drug conjugates (ADCs) are effective anti-tumor therapies with high specificity, with little toxicity and side effects. Xenograft tumor models based on immunodeficient mice have been used for evaluating the human anti-tumor efficacy of ADCs. However, the antibody-mediated immune response of ADCs is not well evaluated in immunodeficient mice. To this end, we have developed BALB/c-hPD1 humanized mouse model to evaluate the efficacy of ADCs in combination with immunotherapy. Trastuzumab deruxtecan (T-DXd, DS-8201a) is a HER2-targeting ADC. In vitro efficacy studies showed that T-DXd effectively bound to the HER2-positive cell line SK-BR-3, resulting in strong endocytosis and induction of apoptosis. It has also been shown to kill HER2-negative MDA-MB-468 cells through a bystander effect both in vitro and in vivo. In vivo efficacy studies have demonstrated that ADCs can effectively inhibit human tumor cell growth in immunodeficient mice. In addition to human tumor cell lines, the efficacy of ADCs was also studied in BALB/c-hPD1mice engrafted with murine colon cancer cells model, and the results showed that T-DXd and Keytruda could significantly inhibit CT26-hHER2 tumor growth, with the tumor growth inhibition rates being 57% and 66%, respectively, Tumor growth inhibition rate of the combined treatment group was about 91%, which was superior compared to the efficacy of single drug treatment. The evaluation of Fc segment-mediated effect (such as ADCC, CDC and ADCP) of ADCs antibodies was carried out in humanized immune system mouse models, such as NCG-hIL15 and NCG-hSGM3. In summary, we have established a drug evaluation platform using various humanized mouse models to study the synergistic anti-tumor effects of ADCs combined with immune checkpoint blockade antibodies. Citation Format: Fang Zhu, Hongyan Sun, Qian Lu, Yuan Fang, Jianming Xu, Cunxiang Ju, Hongyu Wang, Santi Suryani Chen, Zhiying Li, Mark Wade Moore, Jing Zhao, Xiang Gao. Efficacy evaluation by novel humanized mouse models for preclinical study of ADCs combined with immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3242.

Los estilos APA, Harvard, Vancouver, ISO, etc.

16

Shi, Qiyun, Xiaowei Qi, Peng Tang, Linjun Fan, Li Chen, Shushu Wang, Guozhi Zhang et al. "Abstract OT2-22-01: Epirubicin, cyclophosphamide and pyrotinib followed by docetaxel, trastuzumab and pyrotinib as neoadjuvant therapy for stage II-III HER2-positive breast cancer: a single-arm, multicenter phase 2 trial". Cancer Research 83, n.º 5_Supplement (1 de marzo de 2023): OT2–22–01—OT2–22–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot2-22-01.

Texto completo

Resumen

Abstract Background: Dual HER2 targeted therapy with pyrotinib (a tyrosine kinase inhibitor targeting HER1, HER2, and HER4) and trastuzumab plus chemotherapy has been approved as neoadjuvant therapy for patients with HER2-positive breast cancer in China based on the results from phase 3 PHEDRA study. However, the optimal chemotherapy partner still needs exploration. This multicenter phase 2 trial (ChiCTR1900022293) aimed to investigate the efficacy and safety of epirubicin, cyclophosphamide and pyrotinib followed by docetaxel, trastuzumab and pyrotinib (ECP-THP) as neoadjuvant therapy for patients with stage II-III HER2-positive breast cancer. Methods: Patients received intravenous epirubicin (90 mg/m2) and cyclophosphamide (600 mg/m2) on day 1 of each cycle for four 21-day cycles, followed by intravenous docetaxel (75 mg/m2) and trastuzumab (8 mg/kg loading dose, followed by 6 mg/kg) on day 1 for 4 cycles. Pyrotinib 400 mg was given orally once daily throughout the neoadjuvant therapy period. Surgery was performed within 16-20 days after the last neoadjuvant therapy. The primary endpoint was total pathological complete response (tpCR, ypT0/is ypN0) rate. Results: Between May 2020 and May 2022, a total of 175 patients enrolled. As of May 31, 2022, 144 patients had undergone surgery; the median age was 51 years (range, 26-67). Sixty-seven (46.5%) of 144 patients had hormone receptor (HR)-negative disease, and 77 (53.5%) had HR-positive disease. The tpCR rate was 67.4% (97/144; 95%CI, 59.3%-74.5%). Patients with HR-negative disease had numerically higher tpCR rate than those with HR-positive disease (73.1% [95%CI, 61.5%-82.3%] vs. 62.3% [95%CI, 51.2%-72.3%]), but without statistical significance (P=0.230). Miller-Payne grade 4 and 5 pathological responses were found in 22 (15.3%) and 97 (67.4%) of 144 patients, respectively. Regarding clinical response to neoadjuvant therapy before surgery, 31 (21.5%) of 144 patients achieved complete response and 99 (68.8%) achieved partial response, with an objective response rate of 90.3% (95%CI, 84.3%-94.1%). Of 161 patients with available safety data, the most common grade ≥3 adverse events included diarrhea (57.1%), white blood cell count decreased (8.7%), and neutrophil count decreased (5.6%). No treatment-related deaths occurred. Conclusions: Patients with stage II-III HER2-positive breast cancer show favorable clinical and pathological response to this ECP-THP neoadjuvant regimen, with an acceptable safety profile. Citation Format: Qiyun Shi, Xiaowei Qi, Peng Tang, Linjun Fan, Li Chen, Shushu Wang, Guozhi Zhang, Mengyuan Wang, Hongying Che, Pengwei Lv, Dejie Chen, Jinhui Hu, Qiuyun Li, Yanwu Zhang, Qiao Yu, Kunxian Yang, Yuan Zhong, Chuang Chen, Zemin Zhou, Liyuan Qian, Jingwei Zhang, Mingde Ma, Yi Sun, Jiangbo Liu, Yi Zhang, Jun Jiang. Epirubicin, cyclophosphamide and pyrotinib followed by docetaxel, trastuzumab and pyrotinib as neoadjuvant therapy for stage II-III HER2-positive breast cancer: a single-arm, multicenter phase 2 trial [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr OT2-22-01.

Los estilos APA, Harvard, Vancouver, ISO, etc.

17

袁, 杰梅. "A Comparative Reading Inquiry between “Qin Yuan Chun?Changsha” and “Qin Yuan Chun?Snow”". Advances in Education 13, n.º 06 (2023): 3755–59. http://dx.doi.org/10.12677/ae.2023.136595.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

18

Zhang, Jiawei, Josh Wilson y Aimin Song. "(Invited, Digital Presentation) Oxide TFTs Based on Semiconductors and Semimetals". ECS Meeting Abstracts MA2022-02, n.º 35 (9 de octubre de 2022): 1263. http://dx.doi.org/10.1149/ma2022-02351263mtgabs.

Texto completo

Resumen

Oxide semiconductors have opened a new era for large-area, flexible and transparent applications. Despite the progresses, a bottleneck issue of oxide thin-film transistors (TFTs) is the instability either under bias stress or when used as a current source. Furthermore, the carrier mobility and current driving capability need to be improved for high-spec displays. It is still hugely challenging to overcome both issues using the conventional device structure and oxide semiconductor materials. Here, we review our recent work on novel oxide TFTs that show a few desirable properties. Rather than using an ohmic metal contact as the source electrode, a high work-function Schottky source contact enables depletion around the TFT source region, which results in intrinsic immunity to the negative bias illumination stress, no obvious short channel effect, and superb current saturation over a wide range of drain voltage1. The flat saturation current gives rise to an extremely high voltage gain reaching 23,000, which is, to the best of our knowledge, the highest gain ever achieved by a solid-state transistor to date. The threshold voltage is also found to remain stable under different drain voltages, in contrast to standard TFTs, which may be useful in larger-area displays where the drain voltages of the drive TFTs can differ2. Furthermore, the depletion provided by the Schottky source electrode allows utilizing semi-metal ITO to replace IGZO as the TFT channel layer, which significantly enhances the carrier mobility and current driving capability. Other related work may also be discussed in the talk including oxide Schottky diodes operating beyond 10 GHz3, oxide TFTs operating beyond 1 GHz4, significantly enhanced carrier mobility by self-assembled monolayer treatment5,6, and CMOS-like oxide-based logic circuits7,8. References Extremely high-gain source-gated transistors, J Zhang, J Wilson, G Auton, Y Wang, M Xu, Q Xin, A Song, Proceedings of the National Academy of Sciences 116 (11), 4843-4848 (2019) Comparative Study of Short-Channel Effects Between Source-Gated Transistors and Standard Thin-Film Transistors, Zhenze Wang, Li Luo, Yiming Wang, Jiawei Zhang, and Aimin Song, IEEE Transactions on Electron Devices, 69(2), 561 - 566 (2022). Flexible indium–gallium–zinc–oxide Schottky diode operating beyond 2.45 GHz, J Zhang, Y Li, B Zhang, H Wang, Q Xin, A Song, Nature communications 6 (1), 1-7 (2015). Amorphous-InGaZnO thin-film transistors operating beyond 1 GHz achieved by optimizing the channel and gate dimensions, Y Wang, J Yang, H Wang, J Zhang, H Li, G Zhu, Y Shi, Y Li, Q Wang, Qian Xin, Zhongchao Fan, Fuhua Yang, Aimin Song, IEEE Transactions on Electron Devices 65 (4), 1377-1382 (2018). Significant Performance Improvement of Oxide Thin‐Film Transistors by a Self‐Assembled Monolayer Treatment, W Cai, J Zhang, J Wilson, J Brownless, S Park, L Majewski, A Song, Advanced Electronic Materials 6 (5), 1901421 (2020). Significant performance enhancement of very thin InGaZnO thin-film transistors by a self-assembled monolayer treatment, W Cai, J Wilson, J Zhang, J Brownless, X Zhang, LA Majewski, A Song, ACS Applied Electronic Materials 2 (1), 301-308 (2020). Complementary integrated circuits based on p-type SnO and n-type IGZO thin-film transistors, Y Li, J Yang, Y Wang, P Ma, Y Yuan, J Zhang, Z Lin, L Zhou, Q Xin, Aimin Song, IEEE Electron Device Letters 39 (2), 208-211 (2017). Thin Film Sequential Circuits: Flip-Flops and a Counter Based on p-SnO and n-InGaZnO, Y Yuan, J Yang, Y Wang, Z Hu, L Zhou, Q Xin, A Song, IEEE Electron Device Letters 42 (1), 62-65 (2020).

Los estilos APA, Harvard, Vancouver, ISO, etc.

19

Xue, Liyan, Jiaqi Wang, Dong Kuang, Jingping Yun, Yuan Li, Lili Jiang, Daoyuan Wu et al. "Abstract 2180: The PD-L1 protein expression in Chinese patients with advanced esophageal cancers: a multi-center retrospective study". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 2180. http://dx.doi.org/10.1158/1538-7445.am2023-2180.

Texto completo

Resumen

Abstract Introduction: Programmed cell death ligand-1 (PD-L1) is the ligand of programmed cell death-1 (PD-1), a member of the immunoglobulin gene superfamily that plays a role in programmed cell death. Accumulating evidence of anti-PD-1 therapy has showed improved survival benefit for esophageal cancer (EC) patients. PD-L1 has emerged as a crucial predictor for efficacy of immunotherapy. However, the understanding of PD-L1 as a biomarker is complicated by various immunohistochemistry platforms, PD-L1 antibodies, scoring systems, and cut-offs for immunotherapy. Although PD-L1 expression has been widely investigated, the real-world PD-L1 expression status in Chinese patients with advanced EC nationwide with unified testing platform, antibody, scoring system and cut-off is largely unrevealed. Methods: The present study was a nationwide multi-center retrospective analysis of data from six centers in China from August 9, 2021, to February 28, 2022. Patients with histologically or cytologically confirmed diagnoses of advanced EC were included. The primary outcome was the prevalence of high PD-L1 expression in patients with advanced EC. Immunohistochemical analysis of PD-L1 expression was performed by using the PD-L1 IHC 22C3 pharmDx assay in EC specimens. PD-L1 protein expression was assessed by using a combined positive score (CPS). The CPS≥ 10 was defined as a high PD-L1 high expression. The Chi-square test, Fisher’s exact test, or Wilcoxon rank sum test was used to compare the PD-L1 prevalence across demographic, clinicopathologic parameters, treatment status and other biomarkers. Results: Out of 488 enrolled patients with advanced EC, 482 patients were included in the final analysis. For all testing EC patients, 207 patients (42.9% [95% CI 38.48-47.50]) were PD-L1 high expression (CPS≥10). Between the PD-L1 high (CPS≥10) group and PD-L1 low (CPS<10) group, there were statistically significant differences in gender (P=0.046), alcohol consumption (P = 0.011), distant metastatic lesion number of patients with stage IV (P = 0.032), surgery (P = 0.012), systemic therapy (P = 0.004), and chemotherapy (P=0.004). Conclusion: In summary, the prevalence of high PD-L1 expression (CPS≥10) in Chinese patients with advanced EC in real-world setting using 22C3 assay is consistent with previous data in global clinical trials. Our findings of the related clinicopathological and treatment features to the PD-L1 expression can provide supplementary information for decision-making of immunotherapy and facilitate the better understanding of mechanism underlying PD-L1 and anti-tumor immunity. Citation Format: Liyan Xue, Jiaqi Wang, Dong Kuang, Jingping Yun, Yuan Li, Lili Jiang, Daoyuan Wu, Pei Duan, Shixun Lu, Yan Jin, Du He, Jing Qian, Wenmin Tang, Yan Wang, Jielin Li, Jianming Ying. The PD-L1 protein expression in Chinese patients with advanced esophageal cancers: a multi-center retrospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2180.

Los estilos APA, Harvard, Vancouver, ISO, etc.

20

Peng, Zhi, Hua Wang, Baorui Liu, Huiting Xu, Zhenyang Liu, Tianshu Liu, Jun Zhang et al. "Abstract CT152: A multicenter Phase II study of savolitinib in patients with MET-amplified gastroesophogeal junction adenocarcinomas or gastric cancer". Cancer Research 83, n.º 8_Supplement (14 de abril de 2023): CT152. http://dx.doi.org/10.1158/1538-7445.am2023-ct152.

Texto completo

Resumen

Abstract Background: MET gene amplification is associated with poor prognosis in gastric cancer (GC) and gastroesophageal junction adenocarcinomas (GEJ). Savolitinib is a potent and highly selective oral MET tyrosine-kinase inhibitor. Here we reported the preliminary efficacy and safety from a phase 2 trial of savolitinib monotherapy in patients (pts) with MET-amplified advanced or metastatic GC/GEJ. (NCT04923932). Methods: Eligible pts had 2L+ GEJ or GC, with MET amplification and measurable lesions. Pts received savolitinib at 600 mg QD for body weight (BW) ≥50 kg, while 400 mg QD for BW <50 kg in 21-day cycles until disease progression or meeting other criteria for end of treatment. Savolitinib BID regimen has also been additionally explored. The primary endpoint was objective overall response rate (ORR) evaluated by Independent Review Committee (IRC). One interim analysis (IA) was pre-defined at the first 20 QD pts who had at least 2 tumor assessments. Results: As of IA, 20 pts were enrolled for QD regimen. Demographics and clinical outcomes are shown in table 1. The mean relative dose intensity of 93.07%. Median duration of exposure was 2.09 months. Confirmed ORR by IRC was 45%, and reached 50% in 16 patients with MET GCN (high) while only 1 PR was observed in 4 patients with MET GCN (low). Duration of response rate at 4-month was 85.7% with median follow up time of 5.5 months. The most common Gr≥3 TRAE (≥5%) were platelet count decreased, hypersensitivity, anemia, neutropenia and hepatic function abnormal. In all pts, only 1 patient discontinued treatment due to grade 4 liver function abnormal (TRAE) and no patient died due to TRAE. Conclusion: Savolitinib monotherapy had manageable safety and showed promising efficacy in pts with MET-amplified GEJ or GC, particularly in pts with MET high GCN. BID regimen is being investigated to further evaluate the efficacy and safety of savolitinib in pts with MET high GCN. Table 1. Pts baseline characteristics and clinical efficacy Baseline Characteristics ITT in IA (n=20) Median age (min, max), yearsSex (male/female), nECOG (0/1/2)Median BMI (min, max), (kg/m2)Primary location of tumor (GC/GEJ)Tumor stage (IV)Prior line of therapy (1/2/≥3)MET GCN (high/low) 57.00 (39.5, 76.8)17/33/15/220.8 (14.9, 25.8)16/4205/10/516/4 Clinical Efficacy By IRC By Investigator Confirmed objective response rateDisease control rate4m-DoR rate,% (95% CI) 45%65%85.7 (33.4, 97.9) 40%55%71.4 (25.8, 92.0) Citation Format: Zhi Peng, Hua Wang, Baorui Liu, Huiting Xu, Zhenyang Liu, Tianshu Liu, Jun Zhang, Yuxian Bai, Ying Yuan, Tao Wu, Feng Ye, Qinghua Pan, Jufeng Wang, Enxiao Li, Diansheng Zhong, Yueyin Pan, Yanru Qin, Yan Yang, Yusheng Wang, Aiping Zhou, Yongshun Chen, Dianbao Zhang, Hongli Liu, Xiujuan Qu, Shubin Wang, Ning Liu, Jinsheng Wu, Wei Li, Kejun Nan, Hongming Pan, Jianming Xu, Chunmei Bai, Heling Liu, Jia Wei, Runzhi Chen, Rongrong Li, Wei Li, Jinghong Zhou, Hongyan Yin, Qian Xu, Songhua Fan, Yongxin Ren, Weiguo Su, Lin Shen. A multicenter Phase II study of savolitinib in patients with MET-amplified gastroesophogeal junction adenocarcinomas or gastric cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr CT152.

Los estilos APA, Harvard, Vancouver, ISO, etc.

21

Fang, Xiaona, Shan Liu, Liuxian Ban, Jiao Huang, Jie Luo, Lanqi Gong, Baifeng Zhang et al. "Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 2441. http://dx.doi.org/10.1158/1538-7445.am2023-2441.

Texto completo

Resumen

Abstract Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer and the second leading cause of cancer-related mortality worldwide. The overall prognosis of HCC patients is very poor because it is susceptible to recurrence and metastasis. According to the cancer stem cell (CSC) model, there is a small subset of cancer cells within the tumor bulk that is responsible for tumor relapse and metastasis. CSCs represent cells that can self-renew, initiate tumors, and keep resistant to anti-cancer treatment. However, the fate and signatures of CSCs in HCC remain elusive. Our previous in vitro hepatocyte differentiation model successfully mimicked the liver developmental process from the stage of embryonic stem cells, endoderm, liver progenitor cells, and premature hepatocytes, together with one pair of nontumor and tumor tissue from an HCC patient. We found that the expression of keratin 17 (KRT17) reached its peak at the liver progenitor stage and was down-regulated along with liver development, which shared the same expression pattern with keratin 19 (CK19), a well-known HCC stemness-associated gene. Single-cell RNA sequencing in 9 HCC clinical samples from the GEO dataset revealed that KRT17 was expressed in less than 1% of tumor cells. Moreover, KRT17 shared similar expression patterns among hepatocytes, non-stem like HCC and stem like HCC subpopulations with a panel of hepatic stem cell markers and showed reverse trends with a list of hepatic markers. Clinically, KRT17 was highly expressed in cancer tissues compared to normal counterparts and positively correlated with poor overall survival. Functional assays indicated that KRT17 could considerably facilitate the self-renewal, growth, and metastasis properties of HCC both in vitro and in vivo. Also, KRT17 endowed HCC cells with enhanced resistance to sorafenib treatment. Moreover, the expressions of the CSC marker (CD133) and oncofetal drivers (NANOG and KLF4) were significantly upregulated upon KRT17 overexpression. Bioinformatic analysis using gene expression profiles of patients from the TCGA database revealed that development- and differentiation-related biological processes were dramatically enriched in KRT17-high patients. The underlying molecular mechanism of how KRT17 augments HCC stemness still needs further study. Overall, our study uncovered a new connection between KRT17 and HCC stemness and progression. KRT17 might be a novel marker of CSC and a prognostic biomarker for the treatment of HCC patients. Citation Format: Xiaona Fang, Shan Liu, Liuxian Ban, Jiao Huang, Jie Luo, Lanqi Gong, Baifeng Zhang, Beilei Liu, Jinlin Huang, Yuma Yang, Ching Ngar Wong, Qian Yan, Xin-Yuan Guan. Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2441.

Los estilos APA, Harvard, Vancouver, ISO, etc.

22

Augustin, Birgitta. "Qian Xuan Pounding the Balustrade". Archives of Asian Art 74, n.º 1 (1 de abril de 2024): 1–36. http://dx.doi.org/10.1215/00666637-11169063.

Texto completo

Resumen

Abstract In the late thirteenth century, the poet-painter Qian Xuan 錢選 (style [zi (字)] Shunju 舜举, sobriquets [hao 號] Zhaxi weng 霅溪翁, Yutan 玉潭; ca. 1235–ca. 1307) created a horizontal, multi-colored landscape painting known today as Wang Xizhi Watching Geese and owned by the Metropolitan Museum of Art in New York; a copy of the painting exists in the collection of the National Palace Museum in Taipei. The work depicts a waterside pavilion in which a figure stands with his right hand seemingly resting on the balustrade. This article offers a new interpretation of the painting's scene, and it will argue that the figure's hand on the balustrade is the key to an additional perspective of the painting's artistic statement. It begins by analyzing the painting composition, which includes the artist's inscription, before proceeding to a discussion of balustrade in Song ci-poetry and its significance in Qian Xuan's painting. A closer look at the architecture of the pavilion further reveals that the subject and theme of this painting is that of a dejected Song scholar-poet who laments his country's fate.

Los estilos APA, Harvard, Vancouver, ISO, etc.

23

柯香君, 柯香君. "南管《蘇秦》版本考述". 中正漢學研究 31, n.º 31 (junio de 2018): 115–70. http://dx.doi.org/10.53106/2306036020180600310005.

Texto completo

Resumen

南管戲之確切淵源與發展，向來眾說紛紜，在探尋南管戲淵源時，主要集中於劇目與宋元南戲舊目之關係探討，並以此作為南管戲淵源於宋元戲文之依據。然而是否「同名劇目」就一定源自於「宋元戲文」？是否在劇目情節安排上，彼此就一定存在必然關係？「文化集體性」是文本改寫過程中最主要變因，為符合地域文化之差異性，文本有必要重新詮釋再創，縱使已傳承數百年之經典文本亦同。關於「蘇秦」故事，始自《戰國策》，此後相繼改編成雜劇、傳奇等形式。然而經過時空之傳遞流播，各地改編情節亦有所差異，尤其閩南語系地域，因不同文化氛圍，使得劇作產生地域性之變異。 本文將以泉州南管《蘇秦》為研究對象，針對相同劇目進行版本考述，並從各劇作之「關目情節」與「曲文賓白」兩大面向，比對歷來相關劇作彼此間之承繼與創新，嘗試建構南管戲在地方聲腔演化過程中之地位與價值，以窺見南戲流播之軌跡。  There have been various opinions regarding the precise origin and development of Nanguan Opera. Study on history of Nanguan Opera is mainly based on the relationship between list of opera and old list of Sung Yuang Nanxi and it is regarded as reference of Nanguan Opera originated from Sung Yuan hsi-en. However, is “list of opera of the same name” derived from “Sung Yuan hsi-wen”? Does the relationship exit in the plot arrangement of list of opera? “Cultural collectivism” is the principal factor of text revision. In order to comply with regional and cultural difference, the authors must develop the reinterpretation, even in the classical texts which have been diffused for hundred of years. The story of the Su Qin began with the Intrigues of the Warring States and has since been adapted into dramas, legends, and other forms. However, through the transmission of time and space, there are also differences in the plots of adaptations in various places. In particular, in the Minnan dialect region, due to different cultural atmospheres, the drama produces regional variations. This article will use the Quanzhou Nanguan Su Qin as its research object. Careful research against a version of the same repertoire. This article research project, including “Guanmu”, “Plotline”, “Cyu Wun”, “Binbai”. A careful analysis tbetween inheritance and innovation of the relationship between each scrip. Final, establish to Construct the Position and Value of Nanguan Opera in the Evolution of Local Sound Cavity, to understand the spread of Nanguan Opera.

Los estilos APA, Harvard, Vancouver, ISO, etc.

24

Lavanya, Maruthasalam, Duraisamy Thiruarul, Karuppaiya Balasundaram Rajesh y Zbigniew Jaroszewicz. "Generating novel focal patterns for radial variant vector beam focusing through a dielectric interface". Photonics Letters of Poland 15, n.º 1 (2 de abril de 2023): 7–9. http://dx.doi.org/10.4302/plp.v15i1.1198.

Texto completo

Resumen

Electric and magnetic energy densities as well as energy flux (Poynting vector) for radial variant vector beam focusing through a dielectric interface is analyzed numerically based on vector diffraction theory. The electric and magnetic energy densities are tailored by properly manipulating the radial as well as initial phases to generates novel focal patterns in the focal area. These peculiar properties may find applications in fields such as optical trapping, optical recording, magnetic recording, and magnetic resonance microscopy and semiconductor inspection. Full Text: PDF References S.N. Khonina, I. Golub, "Optimization of focusing of linearly polarized light ", Opt. Lett. 36 352 (2011). CrossRef V.V. Kotlyar, S.S. Stafeev, Y. Liu, L. O'Faolain, A. A. Kovalev, "Analysis of the shape of a subwavelength focal spot for the linearly polarized light", Appl. Opt. 52 330 (2013). CrossRef S. Sen, M.A. Varshney, D. Varshney, "Relativistic Propagation of Linearly/Circularly Polarized Laser Radiation in Plasmas", ISRN Optics. 2013 1 (2013). CrossRef M. Martínez-Corral, R. Martínez-Cuenca, I. Escobar, G. Saavedra, "Reduction of focus size in tightly focused linearly polarized beams", Appl. Phys. Lett. 85 4319 (2004) . CrossRef J. Lekner, "Polarization of tightly focused laser beams", Opt. A: Pure Appl. Opt. 5, 6 (2003). CrossRef H. Guo, X. Weng, M. Jiang, Y. Zhao, G. Sui, Q. Hu, Y. Wang, S. Zhuang, "Tight focusing of a higher-order radially polarized beam transmitting through multi-zone binary phase pupil filters", Opt.Express 21, 5363 (2013). CrossRef C.-C. Sun, C.-K. Liu, "Ultrasmall focusing spot with a long depth of focus based on polarization and phase modulation", Opt. Lett. 28, 99 (2003). CrossRef G.H. Yuan, S.B. Wei, X.-C. Yuan, "Nondiffracting transversally polarized beam", Opt. Lett. 36, 3479 (2011). CrossRef P. Yu, S. Chen, J. Li, H. Cheng, Z. Li, W. Liu, B. Xie, Z. Liu, J. Tian, "Generation of vector beams with arbitrary spatial variation of phase and linear polarization using plasmonic metasurfaces", Opt. Lett. 40, 3229 (2015). CrossRef Z. Chen, T. Zeng, B. Qian, "Complete shaping of optical vector beams", J. Ding, Opt. Express 23, 17701 (2015). CrossRef Z. Liu, Y. Liu, Y. Ke, Y. Liu, W. Shu, H. Luo, S. Wen, "Generation of arbitrary vector vortex beams on hybrid-order Poincaré sphere", Photon. Res. 5, 15 (2017). CrossRef Z. Man, Z. Bai, S. Zhang, J. Li, X. Li, X. Ge, Y. Zhang, S. Fu, "Focusing properties of arbitrary optical fields combining spiral phase and cylindrically symmetric state of polarization", J. Opt. Soc. Am. A 35, 1014 (2018). CrossRef Z. Man, S. Fu, G. Wei, "Focus engineering based on analytical formulae for tightly focused polarized beams with arbitrary geometric configurations of linear polarization", J. Opt. Soc. Am. A 34, 1384 (2017). CrossRef Z. Man et al, "Optical cage generated by azimuthal- and radial-variant vector beams", Appl. Opt. 57 (2018). CrossRef S.S. Stafeev, V.V Kotlyar, A.G. Nalimov, E.S. Kozlova, "The Non-Vortex Inverse Propagation of Energy in a Tightly Focused High-Order Cylindrical Vector Beam", IEEE Photon. J., 11, 1 (2019). CrossRef S.S. Stafeev, V.V. Kotlyar, "Elongation of the area of energy backflow through the use of ring apertures", Opt. Commun.450 (2019) 67-71. CrossRef S.S. Stafeev, V.V. Kotlyar, A.G. Nalimov, "Energy backflow in in a tightly focused high-order cylindrical vector beam", Proc. SPIE 11025, 1102518 (2019). CrossRef N.G. Orji, M. Badaroglu, B.M. Barnes, "Metrology for the next generation of semiconductor devices", Nat. Electron. 1, 532 (2018). CrossRef P. Torok, P. Varga, G.R. Booker, "Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: structure of the electromagnetic field. I", I, J. Opt. Soc. Am. A 12, 2136 (1995). CrossRef P. Torok, P. Varga, Z. Laczik, G.R. Booker, "Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: an integral representation", J. Opt. Soc. Am. A., 12, 325 (1995). CrossRef Z. Zhou, L. Zhu, "Tight focusing of high order axially symmetric polarized beams through a dielectric interface", Optik, 124, 2219 (2013). CrossRef J. Shu, Z. Chen, J. Pu, Y. Liu "Tight focusing of a double-ring-shaped, azimuthally polarized beam through a dielectric interface", J. Opt. Soc. Am. A 31, 1180 (2014). CrossRef K. Hu, Z. Chen, J. Pu., "Generation of super-length optical needle by focusing hybridly polarized vector beams through a dielectric interface", Opt. Lett. 37, 3303 (2012). CrossRef B. Richards, E. Wolf, "Electromagnetic diffraction in optical systems, II. Structure of the image field in an aplanatic system", Proc. R. Soc. London A 253, 358 (1959). CrossRef

Los estilos APA, Harvard, Vancouver, ISO, etc.

25

Kobori, Yasuhiro, Masaaki Fuki, Sadahiro Masuo y Hiroko Yamada. "(Invited) Non-Polymer Organic Solar Cells: Microscopic Phonon Control to Suppress Non-Radiative Voltage Loss Via Charge-Separated State". ECS Meeting Abstracts MA2023-01, n.º 14 (28 de agosto de 2023): 1346. http://dx.doi.org/10.1149/ma2023-01141346mtgabs.

Texto completo

Resumen

Recent remarkable developments on non-fullerene solar cells have reached photoelectric conversion efficiency (PCE) of 18% by tuning the band energy levels in small molecular acceptors. In this respect, development of the small donor molecule is essential. Although several methods have been applied to elucidate the elementary processes of charge carriers in BHJ-OSCs, mechanistic details of non-radiative voltage loss are poorly understood originating from interfacial heterogeneous electron-hole pairs.A recent time-resolved electron paramagnetic resonance (TREPR) study suggested an impact of the recombination process generating the triplet excitons in non-fullerene acceptor solar cells,[1] while geometries and motions of charge-separated (CS) states were elucidated in details by electron spin polarization (ESP).[2-4] Furthermore, although effects of low-frequency nuclear motions (phonon) on the photocarrier generations have been discussed in several literatures,[2,5,6] microscopic origin of the phonon playing a role on the OPV performance is unclear including impact of the phonon assist on primary recombination processes. Here we systematically investigated mechanisms of solar cell performance with diketopyrrolopyrrole (DPP)–tetrabenzoporphyrin (BP) conjugates of C4-DPP–H2BP and C4-DPP–ZnBP where C4 represents butyl group substituted at the DPP unit as small p-type molecules in non-polymer organic solar cells (OSC) with an acceptor of [6,6]-phenyl-C61-buthylic acid methyl ester. We clarified microscopic origins of the photocarrier caused by phonon-assisted 1D electron-hole dissociations at donor:acceptor interface. Using a time-resolved electron paramagnetic resonance, we have characterized controlled charge-recombination by manipulating disorders in π-π donor stacking, ensuring carrier transport through face-on molecular conformations to suppress non-radiative voltage loss via capturing specific interfacial radical pairs separated by 1.8 nm in bulk-heterojunction solar cells. While disordered lattice motions from the π-π stackings via zinc ligation are essential to enhance the entropy for charge-dissociations at the interface, too much ordered crystallinity causes backscattering phonon to reduce OSC performances. References: 1. Gillett, A. J.; Privitera, A.; Dilmurat, R.; Karki, A.; Qian, D.; Pershin, A.; Londi, G.; Myers, W. K.; Lee, J.; Yuan, J.; Ko, S.-J.; Riede, M. K.; Gao, F.; Bazan, G. C.; Rao, A.; Nguyen, T.-Q.; Beljonne, D.; Friend, R. H., The role of charge recombination to triplet excitons in organic solar cells. Nature 2021, 597 (7878), 666-671. 2. Kobori, Y.; Ako, T.; Oyama, S.; Tachikawa, T.; Marumoto, K., Transient Electron Spin Polarization Imaging of Heterogeneous Charge-Separation Geometries at Bulk-Heterojunction Interfaces in Organic Solar Cells. J. Phys. Chem. C 2019, 123 (22), 13472-13481. 3. Jinnai, S.; Murayama, K.; Nagai, K.; Mineshita, M.; Kato, K.; Muraoka, A.; Yamakata, A.; Saeki, A.; Kobori, Y.; Ie, Y., Effects of the rigid and sterically bulky structure of non-fused nonfullerene acceptors on transient photon-to-current dynamics. J. Mater. Chem. A 2022, 20035-20047. 4. Kobori, Y.; Ponomarenko, N.; Norris, J. R., Time-Resolved Electron Paramagnetic Resonance Study on Cofactor Geometries and Electronic Couplings after Primary Charge Separations in the Photosynthetic Reaction Center. J. Phys. Chem. C 2015, 119 (15), 8078-8088. 5. Miura, T.; Tao, R.; Shibata, S.; Umeyama, T.; Tachikawa, T.; Imahori, H.; Kobori, Y., Geometries, Electronic Couplings, and Hole Dissociation Dynamics of Photoinduced Electron–Hole Pairs in Polyhexylthiophene–Fullerene Dyads Rigidly Linked by Oligophenylenes. J. Am. Chem. Soc. 2016, 138 (18), 5879-5885. 6. Martiradonna, L., Riddles in perovskite research. Nat. Mater. 2018, 17 (5), 377-377.

Los estilos APA, Harvard, Vancouver, ISO, etc.

26

Zhou, Qing, Nong Yang, Jun Zhao, Mingfang Zhao, Yan Yu, Ying Yuan, Huijuan Wang et al. "Abstract CT030: Phase I study of IBI351 (GFH925) monotherapy in patients with advanced solid tumors: Updated results of the phase I study". Cancer Research 83, n.º 8_Supplement (14 de abril de 2023): CT030. http://dx.doi.org/10.1158/1538-7445.am2023-ct030.

Texto completo

Resumen

Abstract Background: IBI351 (GFH925) is an irreversibly covalent inhibitor of KRASG12C. Data from prior data cutoffs (primary: Feb, 2022; initial update: July, 2022) showed that IBI351 (GFH925) was well-tolerated and demonstrated promising efficacy in patients (pts) with advanced solid tumors harboring KRAS p.G12C mutation. Here, we update results of this phase I study evaluating IBI351 (GFH925) in pts with advanced solid tumors again. Methods: Pts with locally advanced, recurrent or metastatic solid tumors with KRASG12C mutation for whom standard therapy had failed were enrolled. Phase I dose escalation had an accelerated titration design for dose level 250mg once daily (QD) and a Bayesian optimal interval (BOIN) design with 450-900mg QD and 450-750mg twice daily (BID). The primary endpoints were safety and tolerability. The secondary endpoints were pharmacokinetics (PK), anti-tumor activity of IBI351 (GFH925) monotherapy per RECIST v1.1, and overall survival. Results: As of November 30th, 2022, 74 pts (1 at 250mg QD, 3 at 450mg QD, 9 at 700mg QD, 5 at 900mg QD, 21 at 450mg BID, 31 at 600mg BID and 4 at 750mg BID; 62 men, 12 women; median age: 64 yrs, range: 42-76 yrs) were enrolled, among whom 67 pts had non-small cell lung cancer (NSCLC). Among 67 NSCLC pts, 44.8% pts received ≥2 prior lines of treatment (tx), 38.8% pts had brain metastases; adenocarcinoma was the most common histology (n=66, 98.5%). All 74 pts were included for safety analysis. No dose-limiting toxicity (DLT) were observed in any dose cohorts. The overall safety profile was consistent with the latest previous report, with no new safety signals identified. As of December 15th, 2022, among 67 response-evaluable NSCLC pts across all dose levels, the ORR (by investigator assessment) was 58.2% (95% CI, 45.5-70.2), and the confirmed ORR was 44.8% (95% CI, 32.6-57.4); the disease control rate (DCR) was 92.5% (95% CI, 83.4-97.5). At the 600mg BID dose level (RP2D), the ORR was 63.3% (95% CI, 43.9-80.1), and the confirmed ORR was 50.0% (95% CI, 31.3-68.7), the DCR was 96.7% (95% CI, 82.8-99.9). With a median progression-free survival (PFS) follow-up of 5.5 months (95% CI, 5.3-6.8) for NSCLC pts at the 600mg BID dose level, 21 (70%) pts were continuing treatments, and the median duration of response (DoR) and PFS were not reached. Thirteen out of 15 confirmed responders were still in response. Conclusion: IBI351 (GFH925) was well-tolerated across all doses explored in patients with advanced solid tumors harboring KRAS p.G12C mutation. The data also demonstrated promising efficacy and durable response of IBI351 (GFH925) in previously treated advanced NSCLC. Clinical trial information: NCT05005234. Citation Format: Qing Zhou, Nong Yang, Jun Zhao, Mingfang Zhao, Yan Yu, Ying Yuan, Huijuan Wang, Xingya Li, Xiaorong Dong, Longhua Sun, Tongmei Zhang, Dingzhi Huang, Qian Chu, Jingjing Huang, Sujie Zhang, Mengna Huang, Yuping Shen, Yi-Long Wu. Phase I study of IBI351 (GFH925) monotherapy in patients with advanced solid tumors: Updated results of the phase I study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr CT030.

Los estilos APA, Harvard, Vancouver, ISO, etc.

27

Zhao, Xiaohuan. "Love, Lust, and Loss in the Daoist Nunnery as Presented in Yuan Drama". T’oung pao 100, n.º 1-3 (24 de noviembre de 2014): 80–119. http://dx.doi.org/10.1163/15685322-10013p03.

Texto completo

Resumen

Most studies of either Daoist influences and features or love and romance in Yuan drama concentrate on the male-dominated theme of deliverance (dutuo) or center on the “scholar-beauty” or “scholar-courtesan” romantic relationship, with little attention given to Daoist women involved in love affairs or marriage arrangements. This article aims to bring to light life and love in the Daoist nunnery as featured in Yuan drama, by focusing on transgressive Daoist nuns longing for secular life and sensual love and on lay women whose marriages are arranged by Daoist nuns. Four zaju plays have been selected for textual and thematic analysis, namely, Yuanyang bei (The Mandarin-Duck Quilt), Wangjiang ting (The River-viewing Pavilion), Nüzhen guan (The Cloister of Female Daoists), and Zhuwu ting qin (Listening to the Zither from a Bamboo-Thicketed Cottage). La majorité des études consacrées, suivant les cas, aux influences et aux éléments taoïstes ou aux intrigues romantiques dans le théâtre Yuan, se concentrent soit sur le thème masculin de la délivrance (dutuo), soit sur les idylles entre “lettrés et beautés” ou “lettrés et courtisanes”. En revanche on s’est peu intéressé aux exemples de femmes taoïstes impliquées dans des relations amoureuses ou dans des négociations matrimoniales. Cet article cherche à mettre en évidence la vie et l’amour dans les couvents taoïstes tels que les donne à voir le théâtre Yuan en évoquant des nonnes poussées à transgresser les règles par leur désir de vie laïque et d’amour sensuel et des femmes laïques dont le mariage est arrangé par des nonnes. Quatre pièces de zaju ont été choisies pour une analyse textuelle et thématique : Yuanyuan bei (La couverture aux canards mandarins), Wangjiang ting (Le pavillon donnant sur le fleuve), Nüzhen guan (Le couvent taoïste) et Zhuwu ting qin (Écouter la cithare dans la chaumière).

Los estilos APA, Harvard, Vancouver, ISO, etc.

28

Ayre, Brian G., Fathy E. El-Gebaly y Roisin C. McGarry. "Virus-induced flowering—a tool for cereals". Journal of Experimental Botany 71, n.º 10 (30 de mayo de 2020): 2839–41. http://dx.doi.org/10.1093/jxb/eraa153.

Texto completo

Resumen

This article comments on: Yuan C, Li H, Qin C, Zhang X, Chen Q, Zhang P, Xu X, He M, Zhang X, Tör M, Xue Dawei, Wang H, Jackson S, He Y, Liu Y, Shi N, Hong Y. 2020. Foxtail mosaic virus-induced flowering assays in monocot crops. Journal of Experimental Botany 71, 3012–3023.

Los estilos APA, Harvard, Vancouver, ISO, etc.

29

Kern, Martin. "Cultural Memory and the Epic in Early Chinese Literature: The Case of Qu Yuan 屈原 and the Lisao 離騷". Journal of Chinese Literature and Culture 9, n.º 1 (1 de abril de 2022): 131–69. http://dx.doi.org/10.1215/23290048-9681189.

Texto completo

Resumen

Abstract The present essay combines the theory of Cultural Memory with ideas about textual repertoires, composite text, and distributed authorship that in recent years have been advanced in studies of early and medieval Chinese literature. In its first part, the essay introduces in detail the historical development and key features of Cultural Memory theory. In its second part, it applies this theory to the study of Qu Yuan 屈原 and the Lisao 離騷, the greatest poem of early China. Through detailed philological analysis, the Lisao is described not as a single text by a single author but as a composite, authorless artifact that participates in a larger Qu Yuan discourse distributed across multiple texts in both prose and poetry. This distributed “Qu Yuan Epic” is an anthology of distinct characteristics attributed to the quasi-mythological Qu Yuan persona—a persona that itself emerges as a composite textual configuration into which are inscribed the nostalgic ideals and shifting aspirations of Han imperial literati. This Han social imaginaire recollects the noble exemplar of the old Chu aristocracy; the dual prophecy of the fall of Chu to Qin and of Qin's subsequent collapse; the religious, historical, mythological, and literary traditions of Chu; the embodied paradigm of the ruler-minister relationship; and the gradual formation of the ideal of authorship through the transformation of poetic hero into heroic poet.

Los estilos APA, Harvard, Vancouver, ISO, etc.

30

Yao, Herui, Min Yan, Zhongsheng Tong, Xinhong Wu, Min-Hee Ryu, Jee Hyun Kim, John Park et al. "Abstract CT175: Safety, tolerability, pharmacokinetics, and antitumor activity of SHR-A1811 in HER2-expressing/mutated advanced solid tumors: A global phase 1, multi-center, first-in-human study". Cancer Research 83, n.º 8_Supplement (14 de abril de 2023): CT175. http://dx.doi.org/10.1158/1538-7445.am2023-ct175.

Texto completo

Resumen

Abstract Background: SHR-A1811 is an ADC comprised of a humanized anti-HER2 monoclonal antibody (trastuzumab), a cleavable linker, and a DNA topoisomerase I inhibitor payload. Here we assessed SHR-A1811 in HER2-expressing/mutated unresectable, advanced, or metastatic solid tumors. Methods: Pts were eligible if they had HER2 positive breast cancer (BC), HER2 positive gastric/GEJ carcinoma, HER2 low-expressing BC, HER2-expressing/mutated NSCLC, or other HER2-expressing/mutated solid tumors, and were refractory or intolerant to standard therapy. SHR-A1811 at doses of 1.0-8.0 mg/kg was given Q3W (IV). The primary endpoints were DLT, safety, and the RP2D. Results: From Sep 7, 2020 to Sep 28, 2022, 250 pts who had undergone a median of 3 prior treatment lines in the metastatic setting received at least one dose of SHR-A1811 in dose escalation, PK expansion, and indication expansion part. As of data cutoff on Sep 28, 2022, 1 pt experienced DLT. Treatment-related adverse events (TRAEs) were reported in 243 (97.2%) pts. Grade ≥3 TRAEs, serious TRAEs, and treatment-related deaths were reported in 131 (52.4%), 31 (12.4%), and 3 (1.2%) pts, respectively. Interstitial lung disease (AESI) was reported in 8 (3.2%) pts. Exposures of SHR-A1811, total antibody, and the payload were generally proportional to dose from 3.2 to 8.0 mg/kg. ORR was 61.6% (154/250, 95% CI 55.3-67.7) in all pts. Objective responses were observed in pts with HER2 positive BC (88/108, ORR 81.5%, 95% CI 72.9-88.3), HER2-low BC (43/77, ORR 55.8%, 95% CI 44.1-67.2), urothelial carcinoma (7/11), colorectal cancer (3/10), gastric/GEJ carcinoma (5/9), biliary tract cancer (5/8), NSCLC (1/3), endometrial cancer (1/2), and H&N cancer (1/1). Subgroup analyses of ORR are shown in Table 1. The 6-month PFS rate was 73.9% in all pts. Conclusions: SHR-A1811 was well-tolerated and showed promising antitumor activity in heavily pretreated advanced solid tumors. Table 1. Subgroup analyses of ORR No. of prior treatment lines in metastatic setting in all pts (N=250) HER2 positive BC (N=108) HER2-low BC (N=77) Other tumor types (N=65) ≤3 81.8% (45/55) 58.7% (27/46) 36.7% (18/49) >3 81.1% (43/53) 51.6% (16/31) 31.3% (5/16) Prior anti-HER2 therapies in pts with BC (N=185)* HER2 positive BC (N=108) HER2-low BC (N=77) All BC (N=185) Any 82.2% (88/107, 73.7-89.0) 68.8% (11/16, 41.3-89.0) 80.5% (99/123, 72.4-87.1) Trastuzumab 81.9% (86/105, 73.2-88.7) 75.0% (9/12, 42.8-94.5) 81.2% (95/117, 72.9-87.8) Pertuzumab 83.0% (39/47, 69.2-92.4) 100% (5/5, 47.8-100) 84.6% (44/52, 71.9-93.1) Pyrotinib 86.9% (53/61, 75.8-94.1) 71.4% (5/7, 29.0-96.3) 85.3% (58/68, 74.6-92.7) Lapatinib 80.0% (28/35, 63.1-91.6) 100% (1/1, 2.5-100) 80.6% (29/36, 64.0-91.8) T-DM1 82.4% (14/17, 56.6-96.2) 100% (3/3, 29.2-100) 85.0% (17/20, 62.1-96.8) Other HER2-ADC (except T-DM1)** 60.0% (9/15, 32.3-83.7) 50.0% (2/4, 6.8-93.2) 57.9% (11/19, 33.5-79.8) ORR in pts with tumor types other than BC (N=65) HER2 IHC3+ or IHC2+/ISH+ (N=36) HER2 IHC2+/ISH- or IHC1+ or unknown (N=29) All other tumor types (N=65) % (n/N) 38.9% (14/36) 31.0% (9/29) 35.4% (23/65) ORR was shown as % (n/N, 95% CI) or % (n/N). *ORR is calculated using the number of subjects previously treated with anti-HER2 cancer therapy in advanced/metastatic setting as denominator; 2-sided 95% CIs are estimated using Clopper-Pearson method. **Includes RC48-ADC, A166, DP303c, MRG002, ARX788, TAA013, DX126-262, PF-06804103, and BAT8001. Citation Format: Herui Yao, Min Yan, Zhongsheng Tong, Xinhong Wu, Min-Hee Ryu, Jee Hyun Kim, John Park, Yahua Zhong, Weiqing Han, Caigang Liu, Mark Voskoboynik, Qun Qin, Jian Zhang, Minal Barve, Ana Acuna-Villaorduna, Vinod Ganju, Seock-Ah Im, Changsheng Ye, Yongmei Yin, Amitesh C. Roy, Li-Yuan Bai, Yung-Chang Lin, Chia-Jui Yen, Hui Li, Ki Young Chung, Shanzhi Gu, Jun Qian, Yuee Teng, Yiding Chen, Yu Shen, Kaijing Zhao, Shangyi Rong, Xiaoyu Zhu, Erwei Song. Safety, tolerability, pharmacokinetics, and antitumor activity of SHR-A1811 in HER2-expressing/mutated advanced solid tumors: A global phase 1, multi-center, first-in-human study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr CT175.

Los estilos APA, Harvard, Vancouver, ISO, etc.

31

Langenau, David M., Yun Wei, Qian Qin y Luca Pinello. "Abstract IA014: Stem cell and developmental hierarchies in rhabdomyosarcoma". Clinical Cancer Research 28, n.º 18_Supplement (15 de septiembre de 2022): IA014. http://dx.doi.org/10.1158/1557-3265.sarcomas22-ia014.

Texto completo

Resumen

Abstract Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood and is comprised of at least two major molecular subtypes. Despite sharing features with skeletal muscle, the conservation of underlying cellular hierarchy with human muscle development and the identification of molecularly-defined tumor-propagating cells have not been reported. Using single-cell RNA sequencing of patient-derived RMS, DNA-barcode cell fate mapping, antibody enrichment and functional stem cell assays, and mouse xenograft modeling, we have uncovered tumor cell hierarchies in Fusion-negative (FN-) RMS that are shared with normal human muscle development. We also identified common developmental stages at which tumor cells become arrested. FN-RMS resemble early muscle found in embryonic and larval development, while fusion-positive (FP-) RMS express a highly specific developmental gene program found in muscle cells transiting from embryonic to fetal development at 7-7.75 weeks of age. FP-RMS also have neural-pathway enriched cell states, suggesting less-rigid adherence to muscle development hierarchies in this disease. Finally, we identify a new molecularly-defined tumor-propagating cell in FN-RMS that shares remarkable similarity to the newly described bi-potent, muscle mesenchyme stem/progenitor cell that makes both muscle and osteogenic cells. Citation Format: David M. Langenau, Yun Wei, Qian Qin, Luca Pinello. Stem cell and developmental hierarchies in rhabdomyosarcoma [abstract]. In: Proceedings of the AACR Special Conference: Sarcomas; 2022 May 9-12; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(18_Suppl):Abstract nr IA014.

Los estilos APA, Harvard, Vancouver, ISO, etc.

32

Lei, Shengtong, Tianzhen Ju, Bingnan Li, Jinyang Wang, Tunyang Geng y Ruirui Huang. "Study on Spatial Characteristics, Health Assessment, and Influencing Factors of Tropospheric Ozone Pollution in Qin–Jin Region, 2013–2022". Sustainability 15, n.º 24 (18 de diciembre de 2023): 16945. http://dx.doi.org/10.3390/su152416945.

Texto completo

Resumen

Ozone is a pollutant that is harmful to human health and the troposphere. As a coal base in China, the study of ozone in the Qin–Jin region provides a scientific basis for pollution control and early warning and is of great practical significance. This paper analyzes the spatial and temporal distribution characteristics of tropospheric ozone in the Qin–Jin region from 2013 to 2022. It predicts the tropospheric ozone seasons in 2023 using a combination of ozone monitoring instruments (OMIs), ground stations, and machine learning. It also estimates the loss of health and economic benefits caused by ozone to humans, discusses the multiple factors affecting ozone changes, and identifies ozone-sensitive pollution control areas. The results showed that ozone in the Qin–Jin region spatially tends to increase from northwest to southeast, the Slope showed that ozone in the study area has a slightly increasing trend (0~0.079), the ozone concentration values are much larger than those in other months during the period of April–September, and there is no weekend effect. The predicted mean ozone values for 2023 are 36.57 DU in spring, 50.88 DU in summer, 34.29 DU in fall, and 30.10 DU in winter. The average values of all-cause mortality and economic losses are estimated to be 4591 and 4214 persons and 43.30 and 51.30 billion yuan in 2019 and 2021 in Shanxi Province, and 2498 and 1535 persons and 23.50 and 18.70 billion yuan in 2019 and 2021 in Shaanxi Province, respectively. Natural factors are positively correlated with ozone in the following order, temperature (TEM) > precipitable water (TPW) > vegetation cover (NDVI) > relative humidity (RH), uplift index (LI) is negatively correlated with ozone, and barometric pressure (PS) is mainly uncorrelated. During the period of high ozone pollution in the Qin–Jin region (April–September), emissions of VOCs accelerated ozone production, and emissions of NOx suppressed ozone production in most areas. The high-value pollution period in the Qin–Jin area is mainly a VOC control area, and the synergistic control of NOx and VOCs is secondary.

Los estilos APA, Harvard, Vancouver, ISO, etc.

33

Wu, C. Y., Q. Wang, J. Shi, X. Zhang, R. Du, J. Gu, Q. H. Liu et al. "AB0455 BARICITINIB IN THE TREATMENT OF PATIENTS WITH MODERATE TO SEVERE ACTIVE RHEUMATOID ARTHRITIS IN CHINA: 24-WEEK RESULTS OF POST-MARKETING SAFETY STUDY". Annals of the Rheumatic Diseases 82, Suppl 1 (30 de mayo de 2023): 1418. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2148.

Texto completo

Resumen

BackgroundBaricitinib, an orally selective inhibitor of JAK1 and JAK2, was approved for adult patients with moderate-to-severe rheumatoid arthritis (RA) in China. The recommended dose is 2mg once daily and 4mg once daily in patients who have inadequately responded to baricitinib 2mg once daily (for 3 months) or TNF inhibitors. A single-arm, prospective, non-interventional post-marketing safety study (PMSS) was conducted in Chinese RA patients to describe the safety and effectiveness of baricitinib at 24 weeks.ObjectivesTo describe the safety and effectiveness of baricitinib in real-world setting of treating patients with moderate to severe active RA.MethodsThis PMSS (starting July 2020) included 667 patients with RA treated with baricitinib (2 mg or/and 4mg/day) and followed up for 24 weeks. Safety and effectiveness (disease activity) were assessed for 24 weeks. All statistical analyses are descriptive.ResultsSafety analyses included 667 patients (females=82.3%, mean age=53.3 years, mean RA duration 86.9 months). 106 (15.9%) were ≥65 and <75years and 19 (2.8%) were ≥75 years. 29 (4.3%) had previously received biologic therapy. Baricitinib dose regimen was as follows: 2 mg/day, n = 580 (87.0%); 4 mg/day, n = 53 (7.9%); 2/4 mg, n = 34 (5.1%). Concomitant use of MTX and leflunomide occurred in 54.3% and 35.5%, respectively. The overall exposure of baricitinib was 262.1 patient-years; 197 (29.5%) patients withdrew from the study, mostly for patient’s decision (n = 101). Adverse events (AEs) occurred in 250 (37.5%) patients [serious: 28 (4.2%)]. Two patients (0.3%) died: one of pneumonia and one with no cause reported. The incidence of serious infection, herpes zoster and hepatotoxicity was 0.6%, 1.0%, and 3.4%, respectively. No case met laboratory criteria for potential Hy’s Law (ALT/AST ≥3 x ULN and TBL ≥2 x ULN). Malignancy occurred in one patient (thyroid cancer). No venous thromboembolism (VTE) or major adverse cardiovascular event (MACE) were reported during the study observation period (Table 1).In the effectiveness analysis at Week 24, the proportions of patients achieving remission/ low disease activity were 66.6% (235/353) for DAS28-CRP, 64.6% (228/353) for SDAI, and 63.5% (242/381) for CDAI (Figure 1).ConclusionIn conclusion, the safety and effectiveness profile of baricitinib in this Chinese PMSS was generally similar to that in the global RA population with no VTEs or MACE reported and no new safety signals.ReferencesNIL.Table 1.Safety summary among patients with RA treated with baricitinibn (%) PYE [EAIR]Safety Population (N=667)12 weeks24 weeksAE214 (32.08)124.04 [172.52]250 (37.48)198.58 [125.89]AEs related to study treatmentas judged by the investigator95 (14.24)139.99 [67.86]120 (17.99)236.65 [50.71]Death/2 (0.30)261.30 [0.77]SAE22 (3.30)147.03 [14.96]28 (4.20)256.72 [10.91]SAEs related to study treatmentas judged by the investigator8 (1.20)148.32 [5.39]10 (1.50)260.30 [3.84]Treatment discontinuation due to AEs20 (3.00)148.18 [13.50]24 (3.60)260.79 [9.20]AESISerious infection3 (0.45)148.52 [2.02]4 (0.60)260.99 [1.53]Hepatotoxicity16 (2.40)147.13 [10.87]23 (3.45)256.76 [8.96]VTE0148.63 [0.00]0261.30 [0.00]Herpes zoster, n (%)3 (0.45)7 (1.05)Malignancy, n (%)1 (0.15)1 (0.15)MACE, n (%)00Abbreviations: AE= adverse event; AESI= adverse event with special interest; EAIR= exposure-adjusted incidence rate; MACE= major adverse cardiovascular events; N= number of patients in the safety analysis set; n= number of patients in the specified category; PYE= patient-years of exposure; RA= rheumatoid arthritis; SAE= serious adverse event; VTE= venous thromboembolismUsed EAIR per 100 PYE (patient exposure censored at the event).AESI was based on the judgement of investigator recorded in eCRF (electronic case report form)MACE included myocardial infarction, cardiovascular death, and stroke.Acknowledgements:NIL.Disclosure of InterestsChan-yuan Wu: None declared, Qian Wang: None declared, Jian Shi: None declared, XIUYING ZHANG: None declared, Rong Du: None declared, Jieruo Gu: None declared, Qi-huan Liu: None declared, Jiao Yu Employee of: Eli Lilly and Company, Jia-wei Xu Employee of: Eli Lilly and Company, Yan-jie Zhang Employee of: Eli Lilly and Company, Hao Zhu Employee of: Eli Lilly and Company, Mengtao Li: None declared, Xiaofeng Zeng: None declared.

Los estilos APA, Harvard, Vancouver, ISO, etc.

34

Ren, Chunguang y Xiaoming Yang. "Research on Costume Ideology of the Pre-Qin Period from Perspective of Chu Ci". Asian Social Science 16, n.º 4 (31 de marzo de 2020): 59. http://dx.doi.org/10.5539/ass.v16n4p59.

Texto completo

Resumen

Chu Ci is a collection of poems created by Qu Yuan. It combines the folk songs of the ancestors of the Yangtze river valley with ancient myths and legends, and has a strong local color and unique artistic style. Through the description of costumes in Chu Ci, we can find the formation, development and connection between costume ideology in the pre-Qin period and the ancient Chinese conception of nature, which has a significant influence on the formation of ancient Chinese philosophy and traditional clothing culture.

Los estilos APA, Harvard, Vancouver, ISO, etc.

35

Chemla, Karine. "Numerical Tables in Chinese Writings Devoted to Mathematics: From Early Imperial Manuscripts to Printed Song-Yuan Books". East Asian Science, Technology, and Medicine 44, n.º 1 (25 de junio de 2016): 69–122. http://dx.doi.org/10.1163/26669323-04401005.

Texto completo

Resumen

This article establishes that the discursive parts of the earliest known mathematical manuscripts in Chinese were composed of (at least) two types of elements, marked by two types of texts. The manuscripts alternate continuous text, and text for numerical tables (what I call table-relations). I show that in these manuscripts, the latter were written down as ‘textual tables,’ and that two basic types of style were used for these textual tables. By contrast, tabular layouts have been used for a Qin period object and a Dunhuang manuscript carrying numerical tables. I suggest that these artifacts should be interpreted as computing tools. I further argue that, at least from the eleventh century onwards, diagrammatic tables were introduced into mathematical writings. They were used to write down new types of numerical tables. Diagrammatic features of such texts, like horizontal, vertical and oblique lines, played a key part in the reading, interpretation and use of these table-relations. In this sense, they can be compared with the Qin computing tool. I conclude that the fact that in Song-Yuan times these diagrammatic tables are referred to as ‘diagram tu 圖’ curiously echoes with the history of visual tools attested to in relation to mathematical activity in China.

Los estilos APA, Harvard, Vancouver, ISO, etc.

36

Giang, Đoàn Lê. "TRỞ LẠI VẤN ĐỀ NGUỒN GỐC TRUYỆN KIỀU". Dalat University Journal of Science 11, n.º 2 (25 de abril de 2021): 9. http://dx.doi.org/10.37569/dalatuniversity.11.2.861(2021).

Texto completo

Resumen

In the preface of the book “Kim Van Kieu Thanh Tam Tai Tu” – a Vietnamese translation of the novel “The Tale of Jin Yun Qiao” (金雲翹傳 Kim Van Kieu truyen) – published in 1971, the translator To Nam Nguyen Dinh Diem suggested that the novel “Kim Van Kieu truyen” was not created by a Chinese writer but could have been composed by a Vietnamese Confucian scholar based on Nguyen Du’s verse story “Doan truong tan thanh” (A New Cry from a Broken Heart – the official title of “The Tale of Kieu”). This suggestion seems to have been proved incorrect by many textual studies inside and outside Vietnam. However, the topic has been revived recently. This article presents a comprehensive literature review about “The Tale of Jin Yun Qiao”, adding more documents that we have recently collected in foreign countries, to give a firm conclusion about the origin of “The Tale of Kieu”.

Los estilos APA, Harvard, Vancouver, ISO, etc.

37

Gnezdilov, Vladimir M. "Revision of the genus Symplana Kirby, 1891 (Hemiptera: Fulgoromorpha: Caliscelidae), with notes on genitalic morphology of Augilini and description of three new species from Vietnam and Sumatra". Acta Zoologica Academiae Scientiarum Hungaricae 68, n.º 1 (14 de febrero de 2022): 23–44. http://dx.doi.org/10.17109/azh.68.1.23.2022.

Texto completo

Resumen

The caliscelid genus Symplana Kirby, 1891 is revised, with the type species, S. viridinervis Kirby, 1891, is redescribed based on the lectotype. Three new species are described: Symplana maurici sp. n. and S. vieta sp. n. – from northwestern and central Vietnam and S. sultana sp. n. – from eastern Sumatra. Symplana elongata Meng, Qin et Wang, 2020 is placed in synonymy under S. brevistrata Chou, Yuan et Wang, 1994. Key to species of the genus is given. Peculiarities of connective structure and its connection with an aedeagus as well as fusion of endogonocoxal lobes in ovipositor are discussed and illustrated for different Augilini taxa and compared with other Caliscelidae.

Los estilos APA, Harvard, Vancouver, ISO, etc.

38

HOU, XIAO-HUI y XIANG-SHENG CHEN. "Review of the Oriental bamboo delphacid genus Neobelocera Ding & Yang (Hemiptera: Fulgoromorpha: Delphacidae) with the description of one new species". Zootaxa 2387, n.º 1 (3 de marzo de 2010): 39. http://dx.doi.org/10.11646/zootaxa.2387.1.3.

Texto completo

Resumen

Species in the Oriental bamboo delphacid genus Neobelocera Ding & Yang, 1986 (Hemiptera: Fulgoromorpha: Delphacidae: Delphacinae: Tropidocephalini) are reviewed. The genus consists of 6 species: N. asymmetrica Ding & Yang, 1986 (Yunnan: Jinghong), N. zhejiangensis (Zhu, 1988) (Zhejiang: Hangzhou, Anhui: Langyashan), N. hanyinensis Qin & Yuan, 1998 (Shaanxi: Hanyin), N. lanpingensis Chen, 2003 (Yunnan: Lanping), N. laterospina Chen & Liang, 2005 (Hunan: Zhangjiajie) and N. lii Hou & Chen, sp. nov. (Guangdong: Guangzhou, Zhuhai; Hainan: Diaoluoshan). The generic characteristics are redefined. The main morphological characters, male genitalia of 6 species and female genitalia of 3 species are described or redescribed and illustrated (excluding N. asymmetrica, N. zhejiangensis, and N. hanyinensis). A key to species in the genus is provided.

Los estilos APA, Harvard, Vancouver, ISO, etc.

39

Qiu), Qiu Xiao-ming (X M. y Ding Ning. "Reply to Shi Bing-ren and Qin Yun-wen's Comment". Chinese Physics Letters 14, n.º 11 (noviembre de 1997): 880. http://dx.doi.org/10.1088/0256-307x/14/11/023.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

40

Wang, Yingying, Dazhuan Ge, Tongyan Zhang y Yingjie Wang. "The Sustainable Development of Choronymic Cultural Landscapes in China Based on Geo-Informatic Tupu". Sustainability 11, n.º 16 (9 de agosto de 2019): 4302. http://dx.doi.org/10.3390/su11164302.

Texto completo

Resumen

As a part of cultural landscapes, toponyms with abundant cultural connotations and a long history are valuable cultural heritage assets. Choronyms not only reflect natural and social phenomena but also help with relevant management and naming work. In order to explore the historical development sequence of choronymic cultural landscape evolution, we analyze the spatial–temporal pattern evolution, spatial–temporal variation, spatial association, and semantic evolution of choronymic cultural landscapes since the Qin dynasty. We adopt the sequent snapshot model and an event-based state amendment model to establish a spatio-temporal database. That can provide decision supports and theoretical reference for the sustainable development of toponymic landscapes. Results indicate the following: (1) Spatial distribution of toponym density has been different since the Qin dynasty. The cores of toponym density spread from the middle-lower reaches of the Yellow River to Yangtze Plain, Chengdu Plain, Pearl River Delta Plain. (2) Spatial distribution of choronyms is agglomerative since the Qin dynasty and uneven at national and provincial scales since the Yuan dynasty. Temporal distribution of toponyms at different levels is centralized. (3) Spatial agglomeration phenomena of toponyms are positively clustered in nine periods. The Ming dynasty presents the largest degree of spatial aggregation. (4) Words relevant to blessings, orientation, and hydrological features have high proportions in the top 20 words. (5) Spatial distribution of county-level choronyms named over the last 1000 years and “Millennium Ancient Counties” are unbalanced at national and provincial scales.

Los estilos APA, Harvard, Vancouver, ISO, etc.

41

Pulleyblank, Edwin G. "Ji 姬 and Jiang 姜: The Role of Exogamic Clans in the Organization of the Zhou Polity". Early China 25 (2000): 1–27. http://dx.doi.org/10.1017/s0362502800004259.

Texto completo

Resumen

AbstractsThe rule of surname exogamy, which has been an important feature of Chinese social organization down to recent times, seems to have originated with the Zhou dynasty. Its importance is symbolized in the myth of Jiang Yuan姜媚 or 姜原, the mother of Hou Ji后稷, Lord Millet, the ancestor of the Zhou kings, whose surname was Ji姬. Contrary to a view that has become popular, it is argued that Ji and Jiang could not have been the names of two originally separate peoples with different geographical origins that came together and formed an intermarrying alliance but were the names of the two leading, intermarrying, clans of a single people. After the Zhou conquest of Shang, marriage politics, which required the rulers of originally non-Chinese states to have clan names of the same kind, played an important part in gradually incorporating such states into the Zhou, Hua-Xia華夏, polity. The fact that the surnames Ji and Jiang were also found among peoples known as Rong 戎 who were not recognized as Hua-Xia but were probably also Sino-Tibetan in language seems to be consistent with traditional accounts of Zhou's northwestern origins. The words Ji and Jiang are probably etymologically related and although yang羊 “sheep” plays a phonetic role in the graphs of both the surname Jiang and the ethnic name Qiang 羌, Jiang and Qiang are two separate words and need not have anything to do with one another.

Los estilos APA, Harvard, Vancouver, ISO, etc.

42

Boo-Chai, Khoo. "Qian Yun-liang et al. Reversed forearm island flap with dorsal interosseous artery for reconstruction of postburn deformities of the hand". Plastic and Reconstructive Surgery 89, n.º 2 (febrero de 1992): 390. http://dx.doi.org/10.1097/00006534-199202000-00079.

Texto completo

Los estilos APA, Harvard, Vancouver, ISO, etc.

43

Zhu, Chen y Xin-Yuan Liu. "Cluster Preface: Radicals – by Young Chinese Organic Chemists". Synlett 32, n.º 04 (16 de febrero de 2021): 354–55. http://dx.doi.org/10.1055/s-0040-1706715.

Texto completo

Resumen

(left) received his B.S. degree from Xiamen University in 2003 under the supervision of Prof. Pei-Qiang Huang, and his Ph.D. degree from the Shanghai Institute of Organic Chemistry in 2008 under the supervision of Prof. Guo-Qiang Lin. After postdoctoral research at Gakushuin University, Japan with Prof. Takahiko Akiyama, he moved to the University of Texas Southwestern Medical Center, working as a postdoctoral fellow with Prof. John R. Falck and Prof. Chuo Chen. He was appointed as a professor at Soochow University, China in December 2013. He is currently the Head of the Organic Chemistry Department at Soochow University. His current research interests include radical-mediated transformations, in particular radical rearrangements, and their applications in the construction of natural products and biologically active compounds. Xin-Yuan Liu (right) obtained his B.S. degree from Anhui Normal University (AHNU) in 2001. He continued his research studies at both the Shanghai Institute of Organic Chemistry (SIOC), CAS and AHNU under the joint supervision of Prof. Dr. Shizheng Zhu and Prof. Dr. Shaowu Wang, obtaining his master’s degree in 2004. After a one-year stint in Prof. Gang Zhao’s laboratory at SIOC, he joined Prof. Dr. Chi-Ming Che’s group at The University of Hong Kong (HKU) and earned his Ph.D. degree in 2010. He subsequently undertook postdoctoral studies in Prof. Che’s group at HKU and in Prof. Carlos F. Barbas III’s group at The Scripps Research Institute. At the end of 2012, he began his independent academic career at the Southern University of Science and Technology (SUSTech) and was promoted to a tenured Full Professor of SUSTech in 2018. His research interests are directed towards the design of novel chiral anionic ligands to solve radical-involved asymmetric reactions.

Los estilos APA, Harvard, Vancouver, ISO, etc.

44

Xia, Xiuzheng y Chen Tian. "Technology Based on Interactive Theatre Performance Production and Performance Platform". Scientific Programming 2022 (21 de septiembre de 2022): 1–12. http://dx.doi.org/10.1155/2022/4239474.

Texto completo

Resumen

Drama refers to a comprehensive art that realizes the purpose of narrative through language, movement, dance, music, puppets, and other forms. From the pre-Qin period⟶the Han and Wei periods⟶the Tang, Song, and Jin periods⟶the Yuan Dynasty⟶the late Yuan Ming and Qing periods⟶modern times, the art of opera has been welcomed and recognized by a vast audience since its birth, but it is difficult to inherit the art of Chinese opera. The fundamental reason is that there is no good platform for performance. It should be said that since the beginning of the performing arts, there has also been academic thinking on the practice of this artistic creation, so in the academic field of drama, there is actually drama performance science. Due to the changes of the times, Chinese drama art cannot keep up with the pace of the Internet. Therefore, this article proposed a technical research based on the interactive drama performance production and performance platform. This article mainly talks about face recognition technology and its algorithm, and applies it to theatrical performances and productions. In the following experiments, this technology is also used to create a network platform, and its user experience evaluation effect is good. The theatrical performances and productions of young people were also scored, and the final experimental results showed that: at the minimum required level, which is at least three (or more) dramatic materials in the class, scores are high at both levels. Among them, 94.4% of the classes in the first-level kindergarten and 86.1% of the classes in the second-level kindergarten meet this standard. Most of the two levels are qualified, that is to say, in the performance area, at least three people can perform at the same time, which is enough to show that theatrical performance has been passed down.

Los estilos APA, Harvard, Vancouver, ISO, etc.

45

Wang, Tongxin. "History of Chinese Classical Gardens". International Journal of Education and Humanities 4, n.º 3 (27 de septiembre de 2022): 235–37. http://dx.doi.org/10.54097/ijeh.v4i3.1814.

Texto completo

Resumen

From the beginning of Shang Dynasty to the end of Qing Dynasty the development of Chinese classical landscape gardens went through five periods: the formation period of Shang, Zhou, Qin and Han Dynasties, the transition period of Wei, Jin, Southern and Northern Dynasties, the heyday of Tang Dynasty, the maturity period of Song, Yuan, Ming and Qing Dynasties, and the middle and end of Qing Dynasty. Five thousand years of glorious Chinese culture makes Chinese classical gardens different from Western gardens and Islamic gardens. The unique garden system and style give rise to the unique and profound Chinese classical garden system in world history. Based on the history of Chinese classical gardens, the paper focuses on the historical background of the development of the Song garden, the characteristics of typical gardens and literati gardens in the two Song dynasties, in order to understand the development process of the Song garden more deeply. Under the condition of learning and understanding, the method and concept characteristics of classical garden design in Song Dynasty are inherited and applied to modern garden planning and design.

Los estilos APA, Harvard, Vancouver, ISO, etc.

46

Drobyshev, Yuliy I. y Roman Yu Pochekaev. "Reward for the loyalty, retribution for treachery: judicial practice of Chinggis Khan". RUDN Journal of World History 14, n.º 2 (29 de abril de 2022): 103–21. http://dx.doi.org/10.22363/2312-8127-2022-14-2-103-121.

Texto completo

Resumen

The article is an analysis of judicial activity of Chinggis Khan towards persons who entered his service under different circumstances. Analysis allows to state that Chinggis Khan not always used the same criteria taking his decision on the reward for loyalty and punishment for treachery. Authors attempt to explain the reasons of taking one or another decision by Chinggis Khan and clarify their correlation with political ideology formed by him during the establishing of the Mongol Empire. Besides, it seems that the analysis of specific cases could help trace the process of forming the system of khans court which foundation was laid by Chinggis Khan just during the period of the unification of Mongol tribes at the initial stage of creating of his empire. The source base for the research includes medieval historical works: Secret history of Mongols, Sheng-wu qin-cheng-lu, Compendium of chronicles by Rashid ad-Din, Yuan shih, Altan Tobchi by Lubsan Danzan and some others. Positions of different scholars on decisions of Chinggis Khan are also taken into account.

Los estilos APA, Harvard, Vancouver, ISO, etc.

47

Liu, Yuqing. "A New Model in the Study of Chinese Mythology". Journal of Chinese Humanities 3, n.º 1 (8 de febrero de 2017): 1–22. http://dx.doi.org/10.1163/23521341-12340040.

Texto completo

Resumen

Chinese mythology [shenhua 神話] does not exist independently as a cultural medium like mythology does in the West but, rather, comprises ideological and narrative forms that emerge according to historical and cultural trends. Not only have myths withstood humanity’s conquest of nature, but they have drawn and continue to draw on the mysteries of scientific development for new content. It is possible to identify three highpoints of creativity in the history of Chinese mythology, each corresponding to shifts in the function and nuance of myths. The first highpoint occurred very early on in China’s ancient history, in the period of the Three Sovereigns and Five Emperors [wudi sanwang 五帝三王], when myths were a way to articulate history—that is, history as myth. The second highpoint occurred in the period from the Qin through Jin dynasties, when mythology mainly expounded on philosophy and theory—that is, philosophy as myth. The third highpoint occurred during the Yuan and Ming dynasties, when the narrative content of mythology turned toward the religious—that is, religion as myth.

Los estilos APA, Harvard, Vancouver, ISO, etc.

48

Wang, Dong. "Kangxi's Governance Strategy for the Mongolian Region from Kangxi Qi Ju Zhu". Korean Association for Mongolian Studies 73 (30 de junio de 2023): 213–36. http://dx.doi.org/10.17292/kams.2023.73.213.

Texto completo

Resumen

When discussing Kangxi’s policy of governance in Mongolia, people mostly select Qing Shi Lu,Qin Ding Da Qing Hui Dian, Li Fan Yuan Ze Li and other historical materials, and pay little attention to Kang Xi Qi Ju Zhu, but its historical value cannot be ignored.Especially in the implementation of the Qing Dynasty system, such as the reward of Mongolian princes and the handling of penalty cases in the Mongolian region, which is rarely mentioned in other historical materials, it has great significance for studying the Qing Dynasty’s border policies, Manchu Mongolian relations, and the Qing Dynasty’s Mongolian social system. This article starts with the historical materials of the Mongolian region in the Kangxi Qi Ju Zhu,and explores the ruling measures, containment policies, and management measures of the Kangxi period towards the Mongolian region. Emperor Kangxi’s grace and authority were implemented simultaneously, which not only consolidated the rule, promoted the development of agriculture, animal husbandry, and animal husbandry in the Mongolian region, but also strengthened exchanges with the Mongolian region, promoting ethnic integration.

Los estilos APA, Harvard, Vancouver, ISO, etc.

49

WANG, Mengkun. "The cultural thought of the new era is explained by the inheritance and development of strange novels in the Wei, Jin and the Southern and Northern Dynasties". Region - Educational Research and Reviews 5, n.º 5 (29 de diciembre de 2023): 249. http://dx.doi.org/10.32629/rerr.v5i5.1518.

Texto completo

Resumen

China's strange novels have gone through several stages from the strange stories of the Wei, Jin and the Southern and Northern Dynasties inherited from ancient myths, pre-Qin books, unofficial stories, folk stories, etc. to the prosperity and development of the Wei and Jin Dynasties, the legends of the Tang Dynasty, the vernacular books of the Song and Yuan Dynasties. And then Ming and Qing novels have made the strange stories reach their peak. The inheritance and development of China's novels in Wei, Jin and the Northern and the Southern Dynasties coincided with the new policy of promoting, developing and innovating the excellent traditional culture of China. In order to meet the needs of the times, Marxism should also keep pace with the times, continue to inherit, develop, innovate and change in combination with China's national conditions. From the inheritance and development of strange novels in the Wei, Jin and the Southern and the Northern Dynasties, this article explains the similarities with the thought of cultural inheritance and development in the new era.

Los estilos APA, Harvard, Vancouver, ISO, etc.

50

CHZHOU, Siao. "Imperial jade seals of China: transformations of content and form, artistic features". Bulletin of Lviv National Academy of Arts 49, n.º 49 (25 de diciembre de 2022): 75–88. http://dx.doi.org/10.37131/2524-0943-2022-49-9.

Texto completo

Resumen

The great imperial seals, one of the most prominent jade articles in ancient China, were of great significence in those times. Two of its main components – a carved ornament on the top and a stamp, were not merely symbols of the feudal era, but also demonstrated the high level of technical proficiency of visual arts in ancient China. In the context of the history of the origin and development of jade seals, this article highlights the issues of evoluiton in content, form, and artistic features of the art of large imperial jade seals as it was developing during the long history of Chinese art. The article also highlights the relevance of formal and substantive features of jade seals in contemporary Chinese art, particularly in other types and genres of jade plastic arts. The form of imperial seals was developed during the early days of the Zhou dynasty. The nearly 3,000-year history of its development, spanning the Spring and Autumn period, the Warring States, Qin, Han, Sui and Tai, Song and Yuan, Ming and Qing dynasties, has contributed to the abundance of jade seals, their variety and the richness of their forms. During the first feudal dynasty of China - Qin, when the first highly centralized political system was established, the large imperial seal became a symbol of the emperor's power, and had administrative and social significance. The imperial jade seal had retained its status in long history of China until the end of Qing dynasty. During this period, its form and content were gradually enriched, and a unique and successive culture of the great imperial seal had been created.

Los estilos APA, Harvard, Vancouver, ISO, etc.

Artículos de revistas sobre el tema "Qian Yuan"

Crea una cita precisa en los estilos APA, MLA, Chicago, Harvard y otros