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Literatura académica sobre el tema "Psoraleni"

Autor: Grafiati

Publicado: 10 de marzo de 2023

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Artículos de revistas sobre el tema "Psoraleni"

Diekmann, Janina, Isabell Theves, Kristoffer A. Thom y Peter Gilch. "Tracing the Photoaddition of Pharmaceutical Psoralens to DNA". Molecules 25, n.º 22 (10 de noviembre de 2020): 5242. http://dx.doi.org/10.3390/molecules25225242.

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The psoralens 8-methoxypsoralen (8-MOP), 4,5′,8-trimethylpsoralen (TMP) and 5-methoxypsoralen (5-MOP) find clinical application in PUVA (psoralen + UVA) therapy. PUVA treats skin diseases like psoriasis and atopic eczema. Psoralens target the DNA of cells. Upon photo-excitation psoralens bind to the DNA base thymine. This photo-binding was studied using steady-state UV/Vis and IR spectroscopy as well as nanosecond transient UV/Vis absorption. The experiments show that the photo-addition of 8-MOP and TMP involve the psoralen triplet state and a biradical intermediate. 5-MOP forms a structurally different photo-product. Its formation could not be traced by the present spectroscopic technique.

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Jamalis, Joazaizulfazli, Faten Syahira Mohamed Yusof, Subhash Chander, Roswanira Abd Wahab, Deepak P. Bhagwat, Murugesan Sankaranarayanan, Faisal Almalki y Taibi Ben Hadda. "Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 19, n.º 3 (3 de septiembre de 2020): 222–39. http://dx.doi.org/10.2174/1871523018666190625170802.

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Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder.

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Da Silva, Vinicius Barreto, Daniel Fábio Kawano, Ivone Carvalho, Edemilson Cardoso Conceição, Osvaldo Freitas y Carlos Henrique Tomich de Paula Silva. "Psoralen and Bergapten: In Silico Metabolism and Toxicophoric Analysis of Drugs Used to Treat Vitiligo". Journal of Pharmacy & Pharmaceutical Sciences 12, n.º 3 (9 de diciembre de 2009): 378. http://dx.doi.org/10.18433/j3w01d.

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PURPOSE: to discuss the contribution of psoralen and bergapten metabolites on psoralens toxicity. METHODS: Computational chemistry prediction of metabolic reactions and toxicophoric groups based on the expert systems Derek and Meteor. RESULTS: a total of 15 metabolites were suggested for both psoralen and bergapten based on phase 1 and 2 biotransformations until the 3rd generation. Five toxicophoric substructures were shared among psoralen, bergapten and their corresponding metabolites; one toxicophoric marker (resorcinol) was only identified in bergapten and its biotransformation products. CONCLUSION: Although the toxic effects of psoralens are well known and documented, there is little information concerning the role of their metabolites in this process. We believe this work add to the knowledge of which molecular substructures are relevant to the process of metabolism and toxicity induction, thus guiding the search and development of more effective and less toxic drugs to treat vitiligo.

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Patel, Kanika, Vikas Kumar, Amita Verma, Mahfoozur Rahman y Dinesh Kumar Patel. "Health Benefits of Furanocoumarins ‘Psoralidin’ An Active Phytochemical of Psoralea corylifolia: The Present, Past and Future Scenario". Current Bioactive Compounds 15, n.º 4 (4 de julio de 2019): 369–76. http://dx.doi.org/10.2174/1573407214666180511153438.

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Background: Phytoconstituents of fruits, vegetables, spice and herbs are important for human health. Phytoconstituents play an important role in the growth, development, defensive mechanism, colors, odour and flavors of plants. Psoralea corylifolia Linn (P. corylifolia) commonly known as ‘Bakuchi’ belongs to Leguminosae family widely distributed in China and Southeastern Asian countries. Methods: Various electronic databases such as PubMed, Science Direct, Scopus and Google were searched to collect the data of the present review. Further, all the collected information was categorized into different section as per the aim of the paper. Moreover, analyzed data were also presented in the graphical abstract. Results: Seventy-two research and review papers have been collected and were included in the present review. Nineteen papers contained general information’s of P. corylifolia, Psoralens and psoralidin whereas thirty paper data were presented in the pharmacological activities sections and remaining in the Analytical tools and discussion section. From these databases, we can say that P. corylifolia possesses antibacterial, anti-inflammatory, antifungal, antioxidant, antiflarial, estrogenic, antitumour, and immunomodulatory activities. Psoralens are mainly used in the treatment of psoriasis, vitiligo and dermatitis. Topical or oral psoralens followed by UVA radiation exposure are one of the best treatments of leucoderma. Psoralidin exhibits antioxidant, anti-apoptotic, anti-inflammatory and antitumor activities. Conclusion: This review summarizes an overview of P. corylifolia, psoralen and its derivative psoralidin with respects to their pharmacological activities, medicinal uses, biological activities and bioanalytical aspects. These data will be helpful in the translation of information from traditional to the modern medicine of psoralidin.

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Huseyn A. Abiyev y Khayala R. Mammadova. "Effects of α-tocopherol on phototoxicity of 8 - methoxypsoralene". Magna Scientia Advanced Biology and Pharmacy 2, n.º 1 (30 de marzo de 2021): 01–08. http://dx.doi.org/10.30574/msabp.2021.2.1.0005.

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Effects of singlet oxygen extinguisher α-tocopherol on combined effects of psoralens and UV on erythema photosensitized with 8-methoxypsoralene were investigated. The leading role of the reactions of photocompounds in induction of PUVA - erythema is considered. A characteristic feature of biologically active psoralens is the high value of quantum output of intercombination conversion, due to which, after absorption of light quants, a significant number of psoralen molecules are formed in a triplet excited state. Psoralen derivatives differ greatly in their ability to photosensitize the skin. In the example of 8-psoralens, a correlation was found between the ability to induce erythema by photocompound to double-spiral DNA in vitro. A clear correlation was identified between the ability to photosensitize erythema and form diadducts. Α-tocopherol has been shown to protect the skin from PUVA erythema if presents during irradiation. In the case of application of α-tocopherol after irradiation, the inhibitory effect was not exhibited.

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Zhao, Gen-hua, Cui-ping Yan, Zi-sheng Xu, Qian-qian Gao, Zhi-peng Chen y Wei-dong Li. "The Effect of Salt-Processed Psoralea corylifolia on Generative Organ Targeting". Journal of Analytical Methods in Chemistry 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/7484202.

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Psoralen and isopsoralen are two isomers and main effective components within Psoralea corylifolia. In order to investigate the salt-processing effect on tissue distribution characters of psoralen and isopsoralen, a sensitive and accurate ultrahigh pressure liquid chromatographic tandem mass spectrometric (UHPLC-MS/MS) method has been developed and validated for simultaneous determination of the 2 components in rats’ tissues after administration of the extracts that came from either crude or salt-processed Psoralea corylifolia L. Data displayed that both areas under the curve (AUC) of psoralen and isopsoralen from salt-processed scurfpea fruit group were significantly increased compared with that of the crude herb group, especially in heart (p<0.05), ovary, and testes (p<0.001). Though the RE and RCmax of psoralen and isopsoralen in all of the investigated organs were over 1.0, generative organs kept the maximum value. The experiment manifested that salt-processing of scurfpea fruit can increase the distribution of psoralen and isopsoralen to generative organs, heart and spleen, and the distribution of psoralen and isopsoralen to generative organs is significantly higher compared to heart and spleen (p<0.01). Results indicate that salt-processing of scurfpea fruit can significantly increase the distribution of psoralen and isopsoralen to generative organs.

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Chen, Yuling, Rong Wang y Zilin Chen. "Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with a porphyrin-based porous organic polymer modified capillary". Analytical Methods 11, n.º 1 (2019): 29–35. http://dx.doi.org/10.1039/c8ay01885e.

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Thomas, D. C., D. L. Svoboda, J. M. Vos y T. A. Kunkel. "Strand specificity of mutagenic bypass replication of DNA containing psoralen monoadducts in a human cell extract." Molecular and Cellular Biology 16, n.º 5 (mayo de 1996): 2537–44. http://dx.doi.org/10.1128/mcb.16.5.2537.

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Psoralens are mutagenic compounds of vegetable origin that are used as photosensitizing agents in the treatment of various skin diseases, blood cell cancer, and autoimmune disorders. To study the mechanism of mutagenicity of psoralens in humans, we examined the efficiency and fidelity of simian virus 40 origin-dependent replication in a human cell extract of M13mp2 DNA randomly treated with the psoralen derivative 4'-hydroxymethyl-4,5',8-trimethyl psoralen plus UVA irradiation. Replication of DNA treated with variable amounts of 4'-hydroxymethyl-4,5',8-trimethyl psoralen and a fixed UVA fluence was inhibited in a concentration-dependent manner. However, covalently closed monomer-length circular replication products were observed. Product analysis by renaturing agarose gel electrophoresis after cross-linking with 250- to 280-nm UV light indicated that approximately 1 of 9 psoralen monoadducts was bypassed during in vitro replication. Introduction of product DNA into Escherichia coli to score replication errors in the lacZalpha reporter gene demonstrated that replication of the damaged DNA was more mutagenic than was replication of undamaged DNA. Sequence analysis of lacZ mutants revealed that damage-dependent replication errors were predominantly T.A-->C.G transitions, transversions at C.G base pairs, and deletions of single A.T base pairs, the last occurring most frequently in homopolymeric runs. A comparison of error specificities with two substrates having the replication origin asymmetrically placed on opposite sides of the mutational target suggests that the lagging-strand replication apparatus is less accurate than the leading-strand replication apparatus for psoralen monoadduct-dependent deletion errors. A model is proposed based on the preferential loopout of the monoadducted base from the strand that templates retrograde discontinuous synthesis.

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Grass, Joshua A., Derek J. Hei, Ken Metchette, George D. Cimino, Gary P. Wiesehahn, Laurence Corash y Lily Lin. "Inactivation of Leukocytes in Platelet Concentrates by Photochemical Treatment With Psoralen Plus UVA". Blood 91, n.º 6 (15 de marzo de 1998): 2180–88. http://dx.doi.org/10.1182/blood.v91.6.2180.

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Abstract A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that contaminate platelet preparations. Three psoralens, 8-methoxypsoralen (8-MOP), 4′-aminomethyl 4,5′,8-trimethylpsoralen (AMT), and the novel psoralen S-59, were compared using the following four independent but complementary biological and molecular assays. (1) T-cell viability: Treatment with 150 μmol/L S-59 and 1.0 to 3.0 Joules/cm2 UVA inactivated >5.4 ± 0.3 log10 of T cells in full-sized single-donor plateletpheresis units. Using 1.0 Joule/cm2 UVA, the lowest dose of S-59, AMT and 8-MOP required to reduce the number of T cells to the limit of detection was 0.05 μmol/L, 1.0 μmol/L, and 10.0 μmol/L, respectively. (2) Cytokine synthesis: Treatment with 1.9 Joules/cm2 UVA and 150 μmol/L S-59 or AMT completely inhibited synthesis of the cytokine IL-8 by contaminating leukocytes during 5 days of platelet storage. After treatment with 75 μmol/L 8-MOP and 1.9 Joules/cm2 UVA, only low levels of IL-8 were detected. (3) Psoralen-DNA adduct formation: The combination of 1.9 Joules/cm2 UVA and 150 μmol/L S-59, AMT, or 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 psoralen adducts per 1,000 bp DNA, respectively. (4) Replication competence: Polymerase chain reaction (PCR) amplification of small genomic DNA sequences (242-439 bp) after PCT was inhibited. The degree of PCR amplification inhibition correlated with the level of adduct formation (S-59 > AMT > 8-MOP). In contrast, 2,500 cGy gamma radiation, a dose that inactivates >5 log10 of T cells in blood products, had minimal effect on cytokine synthesis and did not induce sufficient DNA strand breaks to inhibit PCR amplification of the same small DNA sequences. These results demonstrate that leukocytes are sensitive to PCT with psoralens and among the psoralens tested S-59 is the most effective. Therefore, PCT has the potential to reduce the incidence of leukocyte-mediated adverse immune reactions associated with platelet transfusion.

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A photochemical treatment (PCT) process using a novel psoralen and long wavelength ultraviolet light (UVA, 320-400 nm) has been developed to inactivate bacteria and viruses in platelet concentrates. This study evaluated the efficacy of PCT for inactivation of leukocytes that contaminate platelet preparations. Three psoralens, 8-methoxypsoralen (8-MOP), 4′-aminomethyl 4,5′,8-trimethylpsoralen (AMT), and the novel psoralen S-59, were compared using the following four independent but complementary biological and molecular assays. (1) T-cell viability: Treatment with 150 μmol/L S-59 and 1.0 to 3.0 Joules/cm2 UVA inactivated >5.4 ± 0.3 log10 of T cells in full-sized single-donor plateletpheresis units. Using 1.0 Joule/cm2 UVA, the lowest dose of S-59, AMT and 8-MOP required to reduce the number of T cells to the limit of detection was 0.05 μmol/L, 1.0 μmol/L, and 10.0 μmol/L, respectively. (2) Cytokine synthesis: Treatment with 1.9 Joules/cm2 UVA and 150 μmol/L S-59 or AMT completely inhibited synthesis of the cytokine IL-8 by contaminating leukocytes during 5 days of platelet storage. After treatment with 75 μmol/L 8-MOP and 1.9 Joules/cm2 UVA, only low levels of IL-8 were detected. (3) Psoralen-DNA adduct formation: The combination of 1.9 Joules/cm2 UVA and 150 μmol/L S-59, AMT, or 8-MOP induced 12.0 ± 3.0, 6.0 ± 0.9, and 0.7 psoralen adducts per 1,000 bp DNA, respectively. (4) Replication competence: Polymerase chain reaction (PCR) amplification of small genomic DNA sequences (242-439 bp) after PCT was inhibited. The degree of PCR amplification inhibition correlated with the level of adduct formation (S-59 > AMT > 8-MOP). In contrast, 2,500 cGy gamma radiation, a dose that inactivates >5 log10 of T cells in blood products, had minimal effect on cytokine synthesis and did not induce sufficient DNA strand breaks to inhibit PCR amplification of the same small DNA sequences. These results demonstrate that leukocytes are sensitive to PCT with psoralens and among the psoralens tested S-59 is the most effective. Therefore, PCT has the potential to reduce the incidence of leukocyte-mediated adverse immune reactions associated with platelet transfusion.

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Tesis sobre el tema "Psoraleni"

Silva, Lidércia Cavalcanti Ribeiro Cerqueira e. "Desenvolvimento de estratégias analíticas para determinação de flavanonas e psoraleno por CLAE-DAD em sucos de laranjas de diferentes procedências". reponame:Repositório Institucional da UFBA, 2009. http://www.repositorio.ufba.br/ri/handle/ri/9877.

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Este trabalho foi desenvolvido no âmbito do PRONEX – NQA e descreve o estudo através da técnica da Cromatografia Líquida de Alta Eficiência acoplada a detector de arranjo de diodos - CLAE-DAD nas análises de amostras de sucos de laranja obtidos por processos extrativos diversificados (espremidos a mão, extração em condições industriais com posterior comercialização em longo prazo e obtido através de máquinas tipo fresh-in-squeeze) para a identificação de flavonóides e psoraleno. Os diversos sucos foram submetidos às etapas de extração líquido-líquido e posterior análises por CLAE-DAD. Estes procedimentos permitiram identificar e quantificar algumas flavanonas e psoraleno presentes nos sucos cítricos. Dentre as flavanonas se determinou hesperidina, naringina, naringenina e poncirina. As faixas de concentrações destes compostos variaram de 17,8 - 245 mg 100 g-1 para hesperidina, 0,01 – 0,08 mg 100 g-1 para naringina, 0,05 – 0,170 mg 100 g-1 para naringenina e de 0,06 – 0,36 mg 100 g-1 para poncirina. Quanto ao psoraleno, em algumas amostras dos sucos, as concentrações estavam abaixo do limite de quantificação (< 0,02) e variou de < 0,02 – 0,05 mg 100 g-1. Estes resultados sugerem que o modo de obtenção dos sucos e os critérios de extração dos constituintes podem influenciar tanto nos teores dos flavonóides no suco como nas detecções de suas concentrações através da técnica aplicada. Para exames das informações geradas foram empregadas metodologias estatísticas multivariadas por meio de Análises de Componentes Principais (PCA) e Análise de Agrupamentos Hierárquicos (HCA) executando o estudo exploratório dos dados para avaliar tendências e discriminar amostras dos sucos de laranja quanto a sua origem, tipos de tratamentos de extração e características químicas para os teores de flavonóides e psoraleno.
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Miranda, Amanda Rodrigues. "Estudo da eficácia, segurança e tolerabilidade do Brosimum gaudichaudii Trécul em indivíduos adultos portadores de vitiligo". Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/6126.

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Vitiligo is a chronic disease of skin, acquired and idiopathic, characterized by circumscribed depigmented macules or patches. The treatment is still a challenge and don´t have an effective treatment that may improve all patients. The traditional psoralen photosensitizers are options for the treatment of vitiligo. In the Brazilian cerrado is popularly known action of Brosimum gaudichaudii Trécul (BGT), or mamacadela, which is an herbal psoralen. The goal of this study was evaluate the efficacy, safety and tolerability of BGT in adult patients with vitiligo, in topical and systemic presentations. A randomized controlled trial, double-blind and placebo-controlled was conducted. Of the 58 selected patients, 33 were randomized, 17 in the treatment group (G1) and 16 in the placebo group (G2). These remained until the end of the study 10 patients in G1 and G2 in 6 patients. The interventions were 800 mg / day of medication per orally and use of the ointment for 22 weeks, together with graded and daily photoexposure. The effectiveness of the BGT was assessed using the Vitiligo Area Score Index (VASI), applied by a dermatologist at all clinic visits. Already the safety and tolerability were assessed by laboratory tests before and during treatment, and observation of adverse events. All patients were classified with generalized vitiligo. The group that received the medication (G1) improved significantly VASI in intra-group evaluation (p <0.05) and also a higher proportion of repigmentation compared to G2. The VASI don´t have association with the analysis variables (gender, age, skin type, previous treatment, education, emotional stress, time of diagnosis, treatment adherence) (p> 0.05). Adherence to photoexposure was irregular in both groups, and don´t have statistically significant relationship with changes of VASI (p > 0.05). Laboratory tests showed no significant changes. Adverse events were mild and transient and the most common being erythema, and occurred predominantly in G1 patients. Therefore, it can be concluded that the BGT is effective in the treatment of vitiligo, with safe and well tolerated in the long term.
O vitiligo é dermatose crônica adquirida, idiopática, que se manifesta por manchas acrômicas e bem delimitadas. Seu tratamento ainda é um desafio e não existe até o momento intervenção completamente eficaz. Os psoralenos são fotossensibilizantes tradicionais utilizados para o tratamento do vitiligo. No cerrado brasileiro é popularmente conhecida a ação da planta mamacadela (Brosimum gaudichaudii Trécul (BGT)) devido a presença de derivados psoralênicos em sua composição . O presente estudo teve como objetivo avaliar a eficácia, segurança e tolerabilidade de formulações farmacêuticas contendo extrato de raízes de BGT em pacientes adultos portadores de vitiligo, nas apresentações tópica e sistêmica. Foi realizado ensaio clínico randomizado, duplo-cego e placebo-controlado. Dos 58 pacientes selecionados, 33 foram randomizados, sendo 17 no grupo 1 (G1), de tratamento, e 16 no grupo 2 (G2), placebo. Destes, permaneceram até o final do estudo 10 pacientes no G1 e 6 pacientes no G2. Foram administrados 800 mg/dia da medicação, via oral, além da pomada, durante 22 semanas, associados a fotoexposição diária e gradativa. A eficácia do BGT foi avaliada através do Vitiligo Area Score Index (VASI), aplicado por dermatologista em todas as visitas clínicas. Já a segurança e tolerabilidade foram avaliadas pela realização de exames laboratoriais, antes e durante o tratamento, além da observação de eventos adversos. Todos os pacientes foram classificados com vitiligo generalizado. O grupo que recebeu a medicação (G1) apresentou melhora significativa do VASI na avaliação intragrupos (p<0,05) e também maior proporção de repigmentação quando comparado ao G2. O VASI não demonstrou associação com as variáveis de análise (sexo, idade, fototipo, tratamento prévio, escolaridade, estresse emocional, tempo de diagnóstico, adesão ao tratamento) (p>0,05). A adesão à fotoexposição foi irregular em ambos os grupos e não apresentou relação estatisticamente significante com as alterações do VASI (p>0,05). Em consonância, os exames laboratoriais não apresentaram alterações significativas. Os eventos adversos foram leves e transitórios, sendo mais comum o eritema, e ocorreram predominantemente nos pacientes do G1. Portanto, pode-se concluir que o BGT é eficaz no tratamento do vitiligo, sendo seguro e bem tolerado a longo prazo.

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Nguyen, Christophe. "Contribution à l'étude de la production de psoralène (furocoumarine) par la culture in vitro de plantes du genre psoralea (leguminosae)". Vandoeuvre-les-Nancy, INPL, 1992. http://www.theses.fr/1992INPL085N.

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Nous avons étudié la possibilité d'utiliser la culture in vitro de plantes du genre psoralea pour produire du psoralène une molécule photosensibilisante aux nombreuses applications industrielles. Nous avons tout d'abord envisagé la production de ces composés par la culture en milieu liquide de cellules de p. Cinerea. Nous avons constitue un souchier de 131 cals. La variabilité génétique induite par la mise en culture in vitro a été stabilisée pour la moitie d'entre eux. A partir de ces cals, nous avons également initié des cultures de cellules en milieu liquide les suspensions cellulaires. Nous avons mis en évidence que certains cals et suspensions cellulaires synthétisaient une molécule dont le spectre UV était très voisin de celui du psoralene. L'identité de ce compose demande à être confirmée. Nous avons également aborde la production de psoralène par des racines transformées par agrobacterium rhizogenes. Une souche a été inoculée à sept espèces de psoralées pour constituer un souchier de racines transformées. Cependant, nous n'avons jamais pu détecter de psoralène dans les racines transformées alors que des racines prélevées sur les plantes entières en contiennent

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Silva, Filho Omar Paulino. "Obtenção de pellets a partir dos extratos líquidos padronizados de Brosimum gaudichaudii Trécul (Moraceae) ou Lafoensia pacari A. St.-Hil. (Lythraceae)". Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/7463.

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Pellets are spherical solid oral dosage forms that can be used in the development of new pharmaceutical products with standardized plant extracts. Brosimum gaudichaudii Trécul (Moraceae) and Lafoensia pacari A. St.-Hil. (Lythraceae) are typical species from the Cerrado biome. The extract obtained from the roots of B. gaudichaudii is traditionally used in the treatment of vitiligo, its effectiveness is due to the presence of the chemical markers psoralen and bergapten. As for L. pacari, the barks of the branches and trunk are traditionally used in the treatment of gastric ulcers, highly valued for there anti-inflammatory and wound healing because of there ellagic acid content. For each of these species optimal extractive methods exist to obtain standardized liquid extracts. However there are no studies that propose the development of solid oral dosage forms from them. Thus, the present study is aimed at obtaining pellets from the standardized liquid extract of the B. gaudichaudii roots, furthermore to determine the efficiency of a photoprotector coating on the stability of psoralen and bergapten and also obtaining pellets with standardized liquid extract of the L. pacari barks from the branches and trunk. The B. gaudichaudii roots were collected in the city of Jussara, Goiás, and the L. pacari barks in Niquelândia, Goiás. Separately, the raw materials were cleaned, dried in an oven with forced air circulation, then subsequently milled for the extractive process. After the standard liquid extract of B. gaudichaudii had been obtained, six formulas were developed at bench scale. Among these, one stood out by the homogeneity of the lot and the sphericity of its pellets. This formula had been selected to be sacaled-up and it`s composition had been formed by 49.5% (w/w) of microcrystalline cellulose (MCC), 1% (w/w) of hydroxypropylmethyl cellulose (HPMC) and 49.5% (w/w) of that extract. The pellets obtained from the scaled formula were divided into two portions, one of them had been coated with a photoprotective layer and both were subjected to a photostability test. The degradation of the markers had been evident only in the uncoated pellets. The reduction of 1.87% (w/w) in the content of psoralen and 8.1% (w/w) in bergapten content had been observed after 3 J/cm2 exposure to UVB radiation. After exposing to 30 J/cm2 of UVA, there had been a reduction of 24.1% (w/w) of psoralen and 28.48% (w/w) of bergapten. Therefore, the application of the photoprotective coating had been an effective alternative and ensured the stability of the chemical markers after the test. With respect to the liquid extract of L. pacari, 13 formulas were obtained among which only two formed pellets whose batch homogeneity had been greater than 70%. Among them, only one had been chosen to obtain the first scaled-up model. With the production of the scaled-up batch, it had been observed that formulas prepared with a lower proportion of standardized liquid extract of L. pacari had enabled us to obtaing more homogeneous, spherical and a smoother pellets. Based on these results and due to the innovative character of the studies, this work can be used as a model for future trials designed to obtain pellets with standardized liquid extract of B. gaudichaudii or L. pacari.
Pellets são formas farmacêuticas sólidas orais esféricas que podem ser utilizadas no desenvolvimento de novos produtos farmacêuticos a partir de extratos vegetais padronizados. Brosimum gaudichaudii Trécul (Moraceae) e Lafoensia pacari A. St.-Hil. (Lythraceae) são espécies típicas do bioma Cerrado. O extrato obtido das raízes de B. gaudichaudii é utilizado tradicionalmente no tratamento de vitiligo, cuja eficácia se deve pela presença dos marcadores químicos psoraleno e bergapteno. Quanto à espécie L. pacari, são tradicionalmente utilizados as cascas dos galhos e do tronco no tratamento de úlceras gástricas, cuja ação anti-inflamatória e cicatrizante é atribuída ao ácido elágico. Para cada uma destas espécies existem métodos extrativos otimizados para obtenção de extratos líquidos padronizados nos respectivos marcadores químicos. No entanto, não há estudos que proponham o desenvolvimento de formas farmacêuticas sólida orais a partir destes. Assim, o presente trabalho teve como objetivo obter pellets a partir do extrato hidroalcoólico das raízes de Brosimum gaudichaudii, padronizado em psoraleno e bergapteno, determinar a eficácia do revestimento fotoprotetor na estabilidade do psoraleno e bergapteno, além de obter pellets com o extrato hidroalcoólico das cascas dos galhos e do tronco de Lafoensia pacari, padronizado em ácido elágico. As raízes de B. gaudichaudii foram coletadas no município de Jussara, Goiás, e as cascas dos galhos e do tronco de L. pacari em Niquelândia, Goiás. Separadamente, as matérias-primas vegetais foram limpas, secas em estufa com circulação forçada de ar, posteriormente trituradas para a obtenção dos respectivos extratos líquidos padronizados. A partir do extrato líquido padronizado de B. gaudichaudii, foram obtidas seis fórmulas em escala de bancada. Dentre estas, uma se destacou pela homogeneidade do lote e pela esfericidade dos pellets. Deste modo, a fórmula que se destacou foi selecionada e escalonada, sua composição é formada pela mistura de XX% (m/m) de celulose microcristalina (CMC), X% (m/m) de hidroxipropilmetilcelulose (HPMC) e 49,5% deste extrato. Os pellets obtidos a partir da fórmula escalonada foram divididos em duas partes, em uma foi aplicado o revestimento fotoprotetor e ambas foram submetidas ao ensaio de fotoestabilidade. Desse modo, a degradação dos marcadores foi evidente apenas nos pellets sem o revestimento, cuja redução de no teor de psoraleno e bergapteno foi igual a 1,87% (m/m) e 8,1% (m/m), após a exposição a 3 J/cm2 de radiação UVB. Após a exposição a 30 J/cm2 de UVA, houve a redução de 24,1% (m/m) de psoraleno e 28,48% (m/m) de bergapteno. Portanto, a aplicação do revestimento fotoprotetor foi uma alternativa eficaz e garantiu a estabilidade dos marcadores químicos após o ensaio. Com relação ao extrato líquido de L. pacari, foram obtidas 13 fórmulas, dentre as quais apenas duas formaram pellets cuja homogeneidade dos lotes foi superior a 70% e apenas uma foi escolhida como modelo para a obtenção do lote piloto. Com a produção do lote piloto foi observado que fórmulas elaboradas com menor proporção do extrato padronizado de L. pacari e a mecanização do processo de mistura dos componentes da fórmula, possibilitam a obtenção de pellets mais esféricos, homogêneos e com superfície menos irregular. Diante dos resultados obtidos e devido ao caráter inovador dos estudos realizados, este trabalho pode ser utilizado como modelo para ensaios futuros destinados a obtenção de pellets com o extrato líquido padronizado de B. gaudichaudii ou L. pacari.

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Sándor, Zoltán. "Mutagenic properties of psoralen-modified triple helix forming oligonucleotides". Lund : Dept. of Medical Microbiology, Malmö General Hospital, Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39774150.html.

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Krieger, Célia. "Identification moléculaire et caractérisation fonctionnelle d'une nouvelle sous-famille de cytochromes P450, CYP71AZ, impliquée dans la synthèse de furanocoumarines et coumarines chez Pastinaca sativa". Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0185/document.

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Les furanocoumarines (FCs) sont des métabolites secondaires principalement synthétisés chez quatre familles botaniques et dérivent de la voie de biosynthèse des phénylpropanoïdes. Ces phytoalexines interviennent dans les processus de défense de la plante et présentent un fort potentiel thérapeutique. Des travaux réalisés dans les années 1960 sur des cultures cellulaires en parallèle de l’utilisation de précurseurs radiomarqués ont permis de démontrer que de nombreuses enzymes impliquées dans cette voie appartenaient à la famille des cytochromes P450 (P450s). Seules deux d’entre elles avaient pu être identifiées d’un point de vue moléculaire au début de ce travail de thèse. Afin de générer des informations concernant le génome de plantes productrices de FCs, nous avons fait séquencer les ARNm extraits de feuilles de Pastinaca sativa, de Ruta graveolens et de Cullen cinereum. L’analyse in silico de ces trois banques de données a permis d’identifier près de 800 fragments d’ADNc codants pour des P450s. Des travaux antérieurs réalisés au laboratoire et l’analyse comparative des transcriptomes de ces 3 plantes nous ont amenés à nous focaliser sur la sous-famille CYP71AZ au travers d’une étude fine de CYP71AZ3 et CYP71AZ4. La caractérisation fonctionnelle de ces enzymes a été réalisée dans un système d’expression hétérologue eucaryote : Saccharomyces cerevisiae. Les résultats obtenus ont permis de montrer que CYP71AZ4 avait une spécificité de substrat assez large puisqu’elle pouvait métaboliser au moins une FC et 4 coumarines. L’analyse et la comparaison des constantes cinétiques pour chacun de ces substrats indiquent néanmoins que le psoralène est le substrat préférentiel. La caractérisation fonctionnelle de CYP71AZ3 a mis en évidence que cette enzyme pouvait hydroxyler l’esculétine, une coumarine, mais ne jouait aucun rôle dans la synthèse de FCs. Ces travaux mettent en évidence la diversité fonctionnelle au sein d’une même sous-famille enzymatique et permettent d’émettre des hypothèses nouvelles quant à l’apparition de cette voie de biosynthèse chez les Apiacées d’une part, et chez les autres familles botaniques d’autre part
Furanocoumarins (FCs) are secondary metabolites mainly synthetized in four botanical families deriving from the phenylpropanoid biosynthetic pathway. These phytoalexins are involved in plant defense mechanisms and present strong therapeutic potential. Early studies in the 1960s based on cell cultures and the use of radiolabeled precursors have shown that many enzymes involved in this pathway belong to the cytochrome P450 family (P450s). Only two of them had been identified from a molecular point of view at the beginning of this thesis. In order to generate information regarding the genome of plants producing FCs, we sequenced the mRNA extracted from leaves of Pastinaca sativa, Ruta graveolens, and Cullen cinereum. In silico analysis of these three libraries identified nearly 800 cDNA fragments encoding for P450s. Previous studies in the laboratory and comparative transcriptome analysis of these three plants have led us to focus on the subfamily CYP71AZ through a detailed study of CYP71AZ3 and CYP71AZ4. Functional characterization of these enzymes was performed in an eukaryote heterologous expression system: Saccharomyces cerevisiae. The results showed that CYP71AZ4 had a broad substrate specificity enough as it could metabolize one FC and 4 coumarins. The analysis and comparison of the kinetic constants for each of these substrates indicate, however, that the preferred substrate is psoralen. The functional characterization of CYP71AZ3 showed that this enzyme could hydroxylate esculetin, a coumarin, but played no role in the synthesis of FCs. This study highlights the functional diversity within a single enzyme subfamily and allows to issue new hypotheses about the emergence of this biosynthetic pathway in Apiaceae on one hand, and among other botanical families on the other hand

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Doerper, Sébastien. "Modification de la synthèse des furocoumarines chez Ruta graveolens L. par une approche de génie métabolique". Thesis, Vandoeuvre-les-Nancy, INPL, 2008. http://www.theses.fr/2008INPL070N/document.

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La rue officinale (Ruta graveolens L) est une plante connue comme étant particulièrement riche en métabolites secondaires et produisant notamment des molécules d’intérêt pharmaceutique comme les furocoumarines. Nous avons tenté par une approche de génie métabolique d’augmenter la teneur en furocoumarines produites dans les plantes. La mise en place de telles approches nous a également permis de mieux comprendre les mécanismes de régulation de la voie de biosynthèse des phénylpropanoïdes. Pour atteindre ces objectifs nous avons transformé la rue avec différents gènes placés sous le contrôle d’un promoteur constitutif fort, le promoteur 35S du CaMV. Pour chaque série de transformants nous avons étudié la teneur en furocoumarines et analysé les variations de composés phénylpropanoïdes (rutine, umbelliférone, ferulate, scopolétine). Parallèlement à cette analyse métabolique, une corrélation a été réalisée avec le niveau d’expression des transgènes et de certains endogènes par l’utilisation d’approche de PCR quantitative. Les séries de plantes transgéniques surexprimant les gènes codants pour la Coumaroyl ester 3’-Hydroxylase de rue (CYP98A22) et d’A. thaliana (CYP98A3) présentent toutes les deux une augmentation significative d’une facteur 3 de la teneur en furocoumarines. Par contre si les premières sont caractérisées par une diminution de la production en rutine et en umbelliférone, les secondes présentent une augmentation importante de la teneur en Scopolétine et en umbelliférone. Ces résultats suggèrent la coexistence de deux C3’H chez R. graveolens ayant des fonctions différentes, l’une d’entre elles étant impliquée directement ou non dans la synthèse de scopolétine. Si la transformation génétique de rues avec des gènes de la famille CYP98A induit des modifications du métabolisme secondaire, la surexpression d’un gène spécifique à la voie de biosynthèse des furocoumarines (gène cyp71AJ1, codant pour la psoralène synthase d’A. majus) permet d’augmenter uniquement la teneur en furocoumarines (X4). L’ensemble de ces travaux a permis de montrer l’intérêt d’une approche de génie métabolique pour générer des plantes présentant un intérêt potentiel pour la production de molécules d’intérêts pharmaceutiques
Garden Rue (Ruta graveolens L.) is a plant known as being particularly rich in secondary metabolites and in particular producing molecules of pharmaceutical interest like furocoumarines. By the use of a metabolic engineering approach, we tried to increase the content of furocoumarines produced in these plants but also to better understand the regulation mechanisms of the phenylpropanoïd biosynthesis pathway. To achieve these goals we transformed Ruta plants with various genes placed under the control of a strong constitutive promoter, CaMV 35S promoter. The plants we obtained were analyzed for their ability to overproduce furocoumarines but also other phenylpropanoïds like ferulate, umbelliferone, scopoletine or rutin. Using Real Time PCR experiments, a correlation was carried out with the level of expression of each transgene and several endogenous genes. Plants overexpressing either the Ruta or the Arabidopsis Coumaroyl ester 3 '-Hydroxylase (CYP98A22 and CYP98A3 respectively) display both a significant increase (3 time level) of the furocoumarin. However if the S-98A22 plants are characterized by a reduction in the production of rutin and umbelliferone, S-98A3 transgenic plants display a significant increase scopoletine and umbelliferone content. These results suggest the coexistence of two C3'H having different functions in Ruta. One of them might be involved more specifically in the synthesis of scopoletine. If the transformation of Ruta with genes belonging to the CYP98A family generates an enlarged of the secondary metabolism, we also showed that the overexpression of a gene belonging to the furocoumarins biosynthesis pathway (CYP71AJ1, the psoralen synthase) allowed a specific stimulation. Indeed a 4 time increase of the content of furocouramins was noticed in these transgenic plant lines. This work made it possible to make evidence of the interest of a metabolic engineering approach to generate plants of interest for the production of pharmaceutical molecules

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Reis, Karinna Bannach. "Extrato padronizado de Ruta graveolens L.: avaliação de seu potencial no controle da brusone em arroz". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3066.

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Ruta graveolens has been successfully applied for many human diseases treatment and promises a well succeed alternative for plant diseases control because it has also phytoalexins in its composition. The aim of this study was to standardise the R. graveolens liquid extract and evaluate its potential for controlling rice (Oryza sativa) leaf blast (Magnaporthe oryzae). The drug has been characterized, the liquid extract obtained and the methodology for quantifying the standards components, furanocoumarins psoralen and bergapten, validated by high performance liquide chromatography. The components of essential oil obtained from standardized liquid extract were characterized by gas chromatography-mass spectrometry. In a completely randomized design, conducted in artificial hydrophobic surface with three replications and eleven treatments composed of M. oryzae conidial suspension (105 con.ml-1) mixed with R. graveolens standardized extract (0.01 to 0.10 g.mL-1), or furocoumarins psoralen (0.18 to 1.82 μg. mL-1), or bergapten (0.29 to 2.91 μg. mL-1), or water (control). It was evaluated the inhibition of conidial germination and appressorium formation and the median lethal dose (LD50). A second assay, in a completely randomized design in three replications was conducted in greenhouse conditions. It was composed of 21 days old rice plants, which were sprayed with a mixture containing M. oryzae conidial suspension (3x105 con.ml-1) and R. graveolens extract, without dilution, or furocoumarins psoralen (18.26 μg. mL-1), or bergapten (29.14 μg. mL-1), or water (control). Nine days after inoculation, leaf blast severity was scored with a diagrammatic scale, the data were statistically analyzed and means compared. The standardized plant extract inhibited M. oryzae conidial germination (LD50=0.237mg) and appressorium formation (LD50=0.121 mg) up to 100% and reduced 80.84% of leaf blast. By fluorescence microscopy it was possible to observe that standardized plant extract did not damage M. oryzae cell wall and plasma membrane, indicating another type of interaction to inhibit conidia development. Isolated standards furanocoumarins psoralen and bergapten did not inhibit conidial germination and appressorium formation and reduce leaf blast severity proportionally, suggesting that synergistic interactions between extract and essential oil components were responsible for the success of R. graveolens in suppressing rice disease, making it an alternative to compose rice blast management.
Ruta graveolens é utilizada com sucesso no tratamento de diversas patologias humanas e possui potencial para o controle alternativo de fitopatógenos, pois também apresenta fitoalexinas em sua composição. O objetivo deste estudo foi padronizar o extrato vegetal líquido de R. graveolens e avaliar seu potencial para o controle da brusone foliar. O material vegetal foi caracterizado, o extrato líquido obtido e a metodologia para a quantificação dos padrões psoraleno e bergapteno foi validada por cromatografia líquida de alta eficiência. Os componentes do óleo essencial obtidos a partir do extrato líquido padronizado foram caracterizados por cromatografia gasosa acoplada à espectrometria de massas. No ensaio conduzido em superfície hidrofóbica artificial, com três repetições e onze tratamentos, 10 μL da suspensão de conídios de Magnaporthe oryzae (105 con/mL) foram misturadas com o extrato vegetal padronizado (0,01 a 0,10 g/mL), ou as furanocumarinas psoraleno (0,18 a 1,82 μg/mL) e bergapteno (0,29 a 2,91 μg/mL), ou água (controle). Avaliou-se a inibição da germinação conidial e da formação dos apressórios determinando-se a dose letal capaz de inibir 50% dos indivíduos (DL50). No experimento conduzido em casa de vegetação e com três repetições, plantas de arroz com 21 dias após plantio foram pulverizadas com uma suspensão de conídios de M. oryzae (3x105 com/mL) misturada com extrato vegetal padronizado sem diluição, ou psoraleno (18,26 μg/mL), ou bergapteno (29,14 μg/mL), ou água (controle). Após nove dias da inoculação, avaliou-se a severidade de brusone foliar com uma escala de 10 graus, os dados foram analisados estatisticamente e as médias comparadas. O extrato vegetal padronizado inibiu a formação de tubo germinativo (DL50= 0,237 mg) e a formação de apressório (DL50= 0,121 mg) de M. oryzae em até 100%, e reduziu a severidade de brusone nas folhas em 80,84%. Através de microscopia de fluorescência, não foi observada ação do extrato padronizado em membrana plasmática e parede celular de M. oryzae, o que indica outro tipo de interação para inibir o desenvolvimento do conídio. Os padrões psoraleno e bergapteno não inibiram proporcionalmente a germinação e a formação de apressório, como também não reduziram a severidade de brusone nas folhas em sua forma isolada, o que sugere que interações sinérgicas entre os diversos componentes do extrato e do óleo essencial de R. graveolens foram responsáveis pelo sucesso do extrato padronizado em suprimir a brusone foliar, tornando-o uma alternativa para compor o manejo de brusone em arroz.

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Holland, Julie. "Studies on the genetic and biochemical properties of a PUVA hyper-resistant mutant of Escherichia coli". Thesis, Nottingham Trent University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259195.

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BUSSEY, CECILE. "Composes bifonctionnels derives du psoralene : synthese et activite cutanee". Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR13098.

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Nous rapportons la synthese de nouvelles furocoumarines angulaires et lineaires, a partir de furocoumarines naturelles et par construction du systeme tricyclique. Dans un premier chapitre est decrite la preparation d'un compose heterodimerique forme d'une furocoumarine lineaire reliee par une chaine o-alkyle en position 5 a une 3-methylene-2-dihydrofuranone. Dans un deuxieme chapitre, nous decrivons la preparation d'un compose heterodimerique forme d'une furocoumarine angulaire reliee par une chaine alkyle en position 5 a une 3-methylene-2-dihydrofuranone, puis la preparation de furocoumarines lineaires substituees en position 5 par une chaine alkyle. Dans un troisieme chapitre, l'activite des deux composes heterodimeriques sur la peau a ete evaluee en utilisant un modele murin. Ces composes se sont reveles non phototoxiques, et le derive comportant un noyau furocoumarine lineaire a montre au cours d'une experience preliminaire un effet antiproliferatif sur les lymphocytes t

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Libros sobre el tema "Psoraleni"

P, Gasparro Francis, ed. Psoralen DNA photobiology. Boca Raton, Fl: CRC Press, 1988.

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National Toxicology Program (U.S.) y National Cancer Institute (U.S.), eds. Photobiologic, toxicologic, and pharmacologic aspects of psoralens. Bethesda, Md: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute, 1986.

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Ugent, Steven Jay. Antisense oligonucleotides: Psoralen photoreactivity and enzymatic resistance. [S.l: s.n.], 1991.

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B, Fitzpatrick T., ed. Psoralens: Past, present and future of photochemoprotection and other biological activities : proceedings of the International Congress "Psoralens in 1988", Paris (France) April 15th-16th 1988. London: John Libbey Eurotext, 1989.

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Heidel, Bonnie L. Survey for Psoralea hypogaea in the Great Falls Resource Area, Lewistown District, Bureau of Land Management, Montana. Helena, Mont: Montana Natural Heritage Program, 1994.

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Extracorporeal photochemotherapy: Clinical aspects and the molecular basis for efficacy. Austin: R.G. Landes, 1994.

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IARC Working Group on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Some naturally occurring and synthetic food components, furocoumarins, and ultraviolet radiation. Lyon, France: World Health Organization, International Agency for Research on Cancer, 1986.

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Per, Svendsen y Hau Jann, eds. Handbook of laboratory animal science. Boca Raton, FL: CRC Press, 1994.

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(Editor), Thomas B. Fitzpatrick, P. Forlot (Editor), M. A. Pasthak (Editor) y F. Urbach (Editor), eds. Psoralens. John Libbey & Co Ltd, 1989.

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Gasparro, Francis P. Psoralen DNA Photobiology. Editado por Francis P. Gasparro. CRC Press, 2018. http://dx.doi.org/10.1201/9781351076128.

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Capítulos de libros sobre el tema "Psoraleni"

Fassihi, Hiva. "Psoralens". En Handbook of Systemic Drug Treatment in Dermatology, 220–27. 3^a ed. London: CRC Press, 2022. http://dx.doi.org/10.1201/9781003016786-32.

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Bährle-Rapp, Marina. "Psoralene". En Springer Lexikon Kosmetik und Körperpflege, 460. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_8630.

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Dall’Acqua, F. "Psoralens: A Review". En Photosensitisation, 269–78. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_38.

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Forlot, Paul E. "Pigmentogenic Effects of Psoralens". En Photosensitisation, 241–44. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73151-8_33.

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Wagner, Hildebert, Rudolf Bauer, Dieter Melchart y Anton Staudinger. "Fructus Psoraleae – Buguzhi". En Chromatographic Fingerprint Analysis of Herbal Medicines Volume IV, 47–57. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-32328-2_6.

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McKenna, K. E. "PUVA, Psoralens and Skin Cancer". En Skin Cancer and UV Radiation, 416–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60771-4_46.

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Azimova, Shakhnoza S. y Anna I. Glushenkova. "Psoralea bituminosa L." En Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1952.

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Azimova, Shakhnoza S. y Anna I. Glushenkova. "Psoralea corylifolia L." En Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1953.

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Azimova, Shakhnoza S. y Anna I. Glushenkova. "Psoralea drupaceae Bunge." En Lipids, Lipophilic Components and Essential Oils from Plant Sources, 597–98. London: Springer London, 2012. http://dx.doi.org/10.1007/978-0-85729-323-7_1954.

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Khare, C. P. "Psoralea corylifolia Linn." En Indian Medicinal Plants, 1. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-70638-2_1295.

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Actas de conferencias sobre el tema "Psoraleni"

Cheplya, V. S. y S. N. Shahab. "QUANTUM CHEMICAL ANALYSIS OF THE SORPTION INTERACTION BETWEEN PSORALENE AND CARBON DIOXIDE (II)". En SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-358-360.

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Resumen

In this paper, the adsorption properties of psoralen in the interaction with CO with the help of the density functional theory (DFT theory level: wB97XD/6-31G*) in a water solvent are investigated. Definitely unrelated interaction of psoralen and CO by electronic properties such as ENOMO and ELUMO, energy gap between HOMO and LUMO, global hardness.

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Gasparro, Francis P. "Psoralen photobiology and photochemotherapy: perspectives and prospects". En SPIE Institutes for Advanced Optical Technologies 6, editado por Charles J. Gomer. SPIE, 1990. http://dx.doi.org/10.1117/12.2283677.

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Jacques, Steven L., Lisa A. Buckley, Scott A. Prahl y Kenton W. Gregory. "Quantifying psoralen in tissues by fluorescence: dosimetry for psoralen administration followed by ultraviolet A irradiation (PUVA) to block restenosis". En OE/LASE '94, editado por George S. Abela. SPIE, 1994. http://dx.doi.org/10.1117/12.179911.

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Bryantseva, Natalya G. "Photophysical and spectral properties of new psoralen photosensitizers". En SPIE Proceedings, editado por Valery V. Tuchin. SPIE, 2006. http://dx.doi.org/10.1117/12.697353.

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Bryantseva, N. G. y I. V. Sokolova. "Theoretical investigation of absorption spectra from excited states of psoralens". En SPIE Proceedings, editado por Gelii A. Zherebtsov y Gennadii G. Matvienko. SPIE, 2006. http://dx.doi.org/10.1117/12.675192.

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Lysenko, Eugene P., Alla A. Kyagova y Alexander Y. Potapenko. "Mechanism of photobiological effects of psoralens: the involvement of photo-oxidized psoralens as reactive intermediate species in induction of photosensitized hemolysis and skin erythema". En Saratov Fall Meeting 2001, editado por Valery V. Tuchin. SPIE, 2002. http://dx.doi.org/10.1117/12.475620.

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Rocha, M. S. y O. N. Mesquita. "Variation of entropic elasticity of DNA-Psoralen complex under UV light". En Optics & Photonics 2005, editado por Kishan Dholakia y Gabriel C. Spalding. SPIE, 2005. http://dx.doi.org/10.1117/12.619128.

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Kyagova, Alla A., Mekhriban I. Ismailova, Mikhail V. Malakhov y Alexander Y. Potapenko. "Hemolysis induced by psoralen previously photo-oxidized in ethanol or aqueous solutions". En SPIE Proceedings, editado por Valery V. Tuchin. SPIE, 2004. http://dx.doi.org/10.1117/12.578949.

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Kotzerke, J., R. Runge, T. Rosenberg, R. Freudenberg y C. Brogsitter. "Psoralen als Photosensitizer für die Photodynamische Therapie mit Cherenkov-Licht in vitro". En 60. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1746000.

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Buckley, Lisa A., Kenton W. Gregory, Deborah T. Bahlman, HanQun Shangguan, Henner Fahrenbach, Eli Rosenthal y Peter C. Block. "Photochemotherapy of intimal hyperplasia using psoralen activated by uv light in porcine model". En Photonics West '96, editado por R. Rox Anderson. SPIE, 1996. http://dx.doi.org/10.1117/12.239996.

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Informes sobre el tema "Psoraleni"

Shi, Yun-bo. Photochemistry of psoralen-DNA adducts, biological effects of psoralen-DNA adducts, applications of psoralen-DNA photochemistry. Office of Scientific and Technical Information (OSTI), marzo de 1988. http://dx.doi.org/10.2172/5069947.

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Spielmann, Peter Hans. The application of psoralens to the study of DNA structure, function and dynamics. Office of Scientific and Technical Information (OSTI), abril de 1991. http://dx.doi.org/10.2172/10115059.

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Mateeva, Valeria, Doncho Etugov y Grisha Mateev. Efficacy of Systemic PUVA (Psoralen Plus Ultraviolet Light-A) in Bulgarian Patients with Mycosis Fungoides. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, noviembre de 2018. http://dx.doi.org/10.7546/crabs.2018.11.15.

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Perera, Anthonige. Genes Affecting the Repair and Survival of Escherichia coli Following Psoralen-Induced Damage: a DNA Interstrand Crosslinking Agent. Portland State University Library, enero de 2000. http://dx.doi.org/10.15760/etd.2192.

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Cheng, S. Repair of psoralen crosslinks in Escherichia coli: In vitro studies with the RecA protein and (A)BC excinuclease. Office of Scientific and Technical Information (OSTI), mayo de 1990. http://dx.doi.org/10.2172/7192240.

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Livingstone, Dena. The Role of Translesion DNA Polymerase(s) in the Survival of Escherichia Coli Exposed to UVA Light in the Presence of Psoralen and Angelicin. Portland State University Library, enero de 2015. http://dx.doi.org/10.15760/honors.199.

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