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Tesis sobre el tema "Proteins maturation"

Autor: Grafiati

Publicado: 10 de marzo de 2023

Última modificación: 31 de julio de 2025

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1

Gilker, Eva Adeline Gilker. "INTERACTIONS AND LOCALIZATION OF PROTEIN PHOSPHATASES, YWHA PROTEINS AND CELL CYCLE CONTROL PROTEINS IN MEIOSIS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1532699317257539.

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2

Yarbrough, Daniel Kenneth. "Structural and mutational analysis of chromophore maturation in long wavelength fluorescent proteins /." view abstract or download file of text, 2004. http://wwwlib.umi.com/cr/uoregon/fullcit?p3120630.

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Thesis (Ph. D.)--University of Oregon, 2004.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 142-152). Also available for download via the World Wide Web; free to University of Oregon users.

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3

Meissner, Christina Sylvia. "Influence of HCMV proteins pUL71 and pUL77 on viral maturation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16414.

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Die Bildung infektiöser Viruspartikel des humanen Zytomegalievirus (HCMV) ist ein mehr-stufiger Prozess. Sie beginnt mit der Verpackung der DNA in die Kapside im Kern, gefolgt von weiterer Reifung während des Transports durch das Zytoplasma und der abschließenden Freisetzung aus der Zelle. Im Zuge dieser Arbeit wurden zwei Proteine, die Einfluss auf die ebengenannten Prozesse haben, analysiert. Der erste Teil der Arbeit befasst sich mit der funktionellen Charakterisierung des HCMV Pro-teins pUL77. Es ist bekannt, dass das homologe Protein pUL25 in alpha-Herpesvirinae essentiell für die DNA-

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4

Atherton, Ruth Elizabeth. "Catalytic activity and maturation of the metalloprotease-disintegrin protein, MDC9 /." Access full-text from WCMC, 1999. http://proquest.umi.com/pqdweb?did=733095101&sid=8&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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5

Cotta, Doné Stefania. "Nephrin - intracellular trafficking and podocyte maturation /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-411-2/.

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6

Tominaga, Taiga. "Structural studies on cyano group biosynthesis by [NiFe] hydrogenase maturation proteins." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/180637.

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7

Popescu, Costin-Ioan. "Maturation and processing of endogenous and viral proteins in the endoplasmic reticulum." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422667.

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8

Hodson, D. J. "The RNA-binding proteins TIS11b and TIS11d regulate lymphocyte development and maturation." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604134.

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Over-expression studies in cultured B cells showed that both TIS11b and TIS11d were able to block plasma cell differentiation <i>in vitro</i>. This action was specific as class switch recombination was not affected. TIS11b conditional knockout mice showed normal lymphocyte development and maturation and a normal humoral immune response. TIS11b conditional knockout mice lacked marginal zone B cells and had reduced numbers of peritoneal B1 cells. However they mounted a normal humoral response to immunisation with NP-KLH, with normal affinity maturation and a normal memory response. Single knocko

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9

Lyall, Natalie. "The role of RAB2 in the maturation of macrophage phagosomes containing Candida albicans." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238253.

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Phagosome maturation is a dynamic process involving the engulfment and degradation of pathogens by phagocytic cells. However, several pathogens have employed mechanisms that facilitate their survival and escape from the phagosome. The fungal pathogen, Candida albicans, is capable of switching from yeast to hyphal form to facilitate its pathogenicity and escape from the phagosome. Rab GTPases are key regulators in phagosome maturation by mediating interactions with the endocytic pathway and leading to biogenesis of the phagolysosome. The temporal localisation dynamics of Rab2 on maturing phagos

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10

Nangola, Sawitree. "The interference of human immunodeficiency virus assembly and maturation by ankyrin repeat proteins." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112044.

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Le but de ce travail est de découvrir des nouvelles protéines suceptibles d'interférer avec le cycle vital du virus HIV. De par leur repliement, les protéines à motifs ankyrines peuvent constituer une ossature protéique trés bien adaptée à cet objectif. Plusieurs interacteurs spécifiques de la protéine MA-CA du HIV ont été sélectionnées par exposition sur phage à partir d'une bibliothèque de variants d'ankyrines. Trois protéines isolées ont été produites à partir de clones ayant une forte activité de liaison. Le meilleur interacteur protéique (1D4) interagit avec un épitope situié sur le domai

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11

Hua, Ethan Wei. "Maturation of single retinogeniculate projections visualized by in vivo electroporation of fluorescent proteins." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1459290.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed Nov. 10, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references.

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12

Sasaki, Daisuke. "Functional and structural studies on nickel insertion process by archaeal [NiFe] hydrogenase maturation proteins." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157802.

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13

Kaymak, Ebru. "Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/852.

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Maternally supplied mRNAs encode for necessary developmental regulators that pattern early embryos in many species until zygotic transcription is activated. In Caenorhabditis elegans, post-transcriptional regulatory mechanisms guide early development during embryogenesis. Maternal transcripts remain in a translationally silenced state until fertilization. A suite of RNA-binding proteins (RBP’s) regulate these maternally supplied mRNAs during oogenesis, the oocyte-to-embryo transition, and early embryogenesis. Identifying the target specificity of these RNA-binding proteins will reveal their co

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14

Kaymak, Ebru. "Understanding the Sequence-Specificity and RNA Target Recognition Properties of the Oocyte Maturation Factor, OMA-1, in Caenorhabditis elegans: A Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/852.

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Maternally supplied mRNAs encode for necessary developmental regulators that pattern early embryos in many species until zygotic transcription is activated. In Caenorhabditis elegans, post-transcriptional regulatory mechanisms guide early development during embryogenesis. Maternal transcripts remain in a translationally silenced state until fertilization. A suite of RNA-binding proteins (RBP’s) regulate these maternally supplied mRNAs during oogenesis, the oocyte-to-embryo transition, and early embryogenesis. Identifying the target specificity of these RNA-binding proteins will reveal their co

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15

Cole, Jason Nicklaus. "Characterisation of cell wall proteins, virulence factor maturation and invasive disease trigger of Group A streptococcus." Access electronically, 2006. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20070130.144214/index.html.

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16

Fairman, Peter. "The Effect of HIV-1 and Accessory Proteins on Monocyte Derived Dendritic Cell Maturation and Function." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24046.

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Dendritic cells (DCs) are specialized members of the innate immune system that are responsible for the initiation of primary adaptive immune responses whose purpose is to resolve infection and inflammation. During most viral infections, mature dendritic cells present critical viral antigens to naïve T-cells within secondary lymphoid organs, resulting in the generation of an antigen-specific adaptive immune response and clearance of the virus. During infection with HIV-1 however, the virus is not cleared and a chronic systemic infection develops characterized by immune dysfunction, CD4+ T-cell

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17

Pursell, Natalie W. "Hsp90-Mediated Maturation of Kinases and Nuclear Steroid Hormone Receptors: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/535.

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Among heat shock proteins, Hsp90 is unusual because it is not required for the proper folding of most cellular proteins but rather is disproportionally linked to the activation of signal transduction proteins including over forty kinases and many steroid hormone receptors. Mutated forms of many Hsp90 clients are causative agents in cancer, making Hsp90 a promising pharmacological target. Many small molecular inhibitors have been identified that competitively bind to the ATP binding site of Hsp90, some of which are in clinical trials as anticancer agents. Although the activation of kinase and h

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18

Chen, Hui-Chen. "Role for cyclic adenosine monophosphate (cAMP) response element binding proteins in B lymphocyte development and functional maturation." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1061213266.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 19.

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19

Innarella, Maria Rosaria [Verfasser]. "Investigation of the effect of human Argonaute proteins on the maturation of short haipin RNAs / Maria Rosaria Innarella." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2015. http://d-nb.info/106640139X/34.

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20

Braganza, Annabel M. H. (Mary Helen). "Characterization of nascent enamel proteins translated in vitro from mRNA specific for the secretory and maturation stages of amelogenesis." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22851.

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Enamel proteins are extracellular matrix proteins expressed throughout enamel formation. However, questions concerning their numbers and origins are still somewhat ambiguous. To characterize the nascent enamel proteins, cell free translation and immunoprecipitation procedures were performed using poly(A)$ sp{+}$RNA isolated from freeze-dried segments of rat incisor enamel organs at the secretory, early maturation, and mid maturation stages of amelogenesis. Phosphoimaging revealed that the enamel organ produces enamel proteins continuously throughout enamel development albeit in decreasing numb

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21

Cannone, Giuseppe. "Structural investigation of the archaeal replicative machinery by electron microscopy and digital image processing." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17070.

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Previous studies suggest a degree of homology between eukaryotic replication, transcription and translation proteins and archaeal ones. Hence, Archaea are considered a simplified model for understanding the complex molecular machinery involved in eukaryotic DNA metabolism. DNA replication in eukaryotic cells is widely studied. In recent years, DNA replication studies expanded on the archaeal DNA replication machinery. P. abyssi was the first archaeon whose genome was fully sequenced. Genome sequencing and comparative genomics have highlighted an MCM-like protein in P. abyssi. In this study, I

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22

Bohassan, Maruah Hejey. "Role of GPR17 in Thrombocyte Aggregation in Adult Zebrafish." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc822797/.

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GPR17, a uracil nucleotide cysteinyl leukotriene receptor, belongs to the GPCR (G protein coupled receptor) family. It has been shown recently that inhibiting this protein in the nervous system in mice can lead to blockage of oligodendrocyte maturation, which supports myelin repair. Interestingly, our laboratory found GPR17 in thrombocytes. However, we do not know whether it has any function in thrombocyte aggregation or the nature of the ligand. In this paper, we studied the role of GPR17 in hemostasis, which is a fundamental defense mechanism in the event of injury. Using zebrafish as a mode

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23

Fehlker, Marion. "Studien zur Funktion des Proteasomen-assoziierten Proteins Blm3 in Saccharomyces cerevisiae." Doctoral thesis, [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972596860.

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24

Meissner, Christina Sylvia [Verfasser], Elke [Akademischer Betreuer] Bogner, Martin [Akademischer Betreuer] Messerle, and Thorsten [Akademischer Betreuer] Wolff. "Influence of HCMV proteins pUL71 and pUL77 on viral maturation / Christina Sylvia Meissner. Gutachter: Elke Bogner ; Martin Messerle ; Thorsten Wolff." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://d-nb.info/1017797013/34.

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25

Meissner, Christina Sylvia [Verfasser], Elke [Gutachter] Bogner, Martin [Gutachter] Messerle, and Thorsten [Gutachter] Wolff. "Influence of HCMV proteins pUL71 and pUL77 on viral maturation / Christina Sylvia Meissner ; Gutachter: Elke Bogner, Martin Messerle, Thorsten Wolff." Berlin : Humboldt-Universität zu Berlin, 2011. http://d-nb.info/120807671X/34.

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26

Xia, Wei, and 夏炜. "The tango between two proteins: insight into the nickel delivery process exerted by HypA and HypB during [Ni, Fe]-hydrogenase maturation in helicobacter pylori." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46188666.

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27

Pinker, Franziska. "Structural characterization of proteinaceous RNase P from Arabidopsis thaliana." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAJ093/document.

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La maturation des ARNt en 5' est réalisée par RNase P. C'est un ribozyme chez les bactéries, les fungi et les nuclei des mammifères et un enzyme protéique dans les plantes ou des organelles des mammifères qui s’appelle PRORP. Il y a trois PRORP dans A. thaliana. PRORP contiennent deux domaines : un domaine PPR qui reconnaît spécifiquement des séquences d'ARN et un domaine nucléase qui assure la coupure endonucléolytique 5' des précurseurs d’ARNt. Pendant ma thèse j'ai pu montré par des méthodes biophysiques et structurales comme SRCD et SAXS que PRORP1 et 2 sont composées en majorité des hélic

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28

Jarry, Lucas. "Study of Plant Mobile Domain proteins at the interface between Arabidopsis and tomato plants." Electronic Thesis or Diss., Perpignan, 2024. http://www.theses.fr/2024PERP0026.

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Dans le noyau des cellules eucaryotes, l’ADN forme un complexe avec les protéines histones appelé la chromatine. Les modifications de la chromatine, dites épigénétiques, influencent la transcription des gènes. Ces modifications ont aussi un rôle dans la répression des éléments transposables (ETs). Chez Arabidopsis thaliana, les protéines MAINTENANCE OF MERISTEM (MAIN), MAIN-LIKE 1 (MAIL1) et MAIL2 appartiennent à la famille des Plant Mobile Domain (PMD). Les protéines MAIN et MAIL1 interagissent ensemble ainsi qu’avec PROTEIN PHOSPHATASE 7-LIKE (PP7L) afin de réguler la transcription des gènes

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29

Nabhan, Myriam. "Agrégation et immunisation contre les protéines thérapeutiques : étude de la maturation des cellules dendritiques et de la réponse lymphocytaire." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS576.

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L’immunogénicité des biothérapies constitue une limitation majeure au traitement des patients atteints de maladies chroniques et se traduit par la production d’anticorps dirigés contre le biomédicament (anti-drug antibodies, ADA). La détection d’ADA de haute affinité et d’isotypes divers chez les patients suggère la mise en place d’une réponse immunitaire adaptative classique orchestrée par les cellules dendritiques. Par ailleurs, la présence d’agrégats protéiques dans les spécialités administrées serait un des facteurs favorisant l’immunogénicité, ces agrégats pouvant jouer le rôle de signal

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30

Costa, Mariana Fernandes Alves. "Molecular remodelling of the spindle architecture during metaphase arrest in oocytes." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31255.

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Oocytes of most species assemble and maintain a functional bipolar spindle in the absence of centrosomes. Strikingly, after bipolar spindle formation, oocytes arrest in metaphase for several hours before fertilisation. How the dynamic spindle maintains its bipolarity during this long arrest is poorly understood. I hypothesise that the bipolar spindle is stably maintained by changes in the distribution of microtubule-associated proteins (MAPs) on the spindle during the long oocyte arrest. To test this, I generated transgenic flies expressing GFP-tagged microtubule-associated proteins (MAPs), an

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31

Pagnier, Adrien. "Maturation de sites métalliques de protéines par les machineries d'assemblage des centres fer-soufre ISC et Hyd." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV016.

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De nombreuses protéines possèdent des cofacteurs inorganiques contenant des métaux de transition. Les propriétés physico-chimiques de ces métaux permettent aux enzymes qui les portent de catalyser des réactions impossibles par l'utilisation des seules potentialités chimiques des vingt-deux acides aminés. Cependant, ces métaux sont toxiques pour la cellule lorsqu'ils sont libres. La synthèse et l'incorportion de ces cofacteurs dans les enzymes nécessitent alors des machineries protéiques complexes d'assemblage. Au cours de cette thèse, les mécanismes de synthèse des centres FeS par les machiner

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32

Cruz, Larissa Prado da. "Caracterização do proteoma de entrenós maduros e imaturos de cana-de-açúcar durante o estádio de maturação." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11137/tde-05112012-092946/.

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Grandes esforços dos programas de melhoramento genético da cana-de-açúcar são dedicados ao desenvolvimento de novas variedades com maior rendimento e conteúdo de sacarose. As etapas do metabolismo da sacarose têm sido foco de pesquisas há muito tempo, porém apenas recentemente têm-se buscado compreender os processos de transporte e acúmulo da sacarose no colmo da cana-de-açúcar. O objetivo deste trabalho é a caracterização do proteoma de entrenós maduros (entrenó 9) e imaturos (entrenó 5) de dois genótipos de cana-de-açúcar (Co 740 e SP 80-3280), ambos com 12 meses de idade, visando à identifi

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33

Valário, Bárbara Panoff [UNESP]. "Estudo da tolerância à dessecação e longevidade em sementes de soja (Glycine max (L.) MERR.)." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144345.

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Submitted by Bárbara Panoff Valário (barbarapanoff@yahoo.com.br) on 2016-10-07T21:14:48Z No. of bitstreams: 1 Tese correções definitivo setembro 2016.pdf: 3127741 bytes, checksum: d6857da82fb09539bd86f7e77346f4eb (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-10-11T14:05:55Z (GMT) No. of bitstreams: 1 valario_bp_dr_bot.pdf: 3127741 bytes, checksum: d6857da82fb09539bd86f7e77346f4eb (MD5)<br>Made available in DSpace on 2016-10-11T14:05:55Z (GMT). No. of bitstreams: 1 valario_bp_dr_bot.pdf: 3127741 bytes, checksum: d6857da82fb09539bd86f7e

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34

Ghamrawi, Sarah. "Modifications de la paroi au cours de la maturation et de la germination des conidies de Scedosporium boydii." Thesis, Angers, 2014. http://www.theses.fr/2014ANGE0031/document.

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Les espèces du complexe Scedosporium apiospermum sont des agents pathogènes émergents qui se situent au deuxième rang parmi les champignons filamenteux rencontrés au cours de la mucoviscidose. Ils sont omniprésents et particulièrement rencontrés dans les zones polluées. En dépit de leur importance clinique, nos connaissances sur leur biologie moléculaire et leur physiologie restent limitées. Chez les champignons, la paroi constitue un bouclier protecteur face à des conditions environnementales défavorables, et joue un rôle essentiel dans la pathogénicité. Ici, nous avons étudié les changements

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35

Snow, Alan J. "Phosphorylation-dependent interaction of tyrosine 3 monooxygenase/tryptophan 5-monooxygenase activation protein (14-3-3) with PADI6 following oocyte maturation in mice." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1208796428.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed May 26, 2009). Advisor: Douglas W. Kline. Keywords: oocyte, egg, ovum, PADI6, PAD6, 14-3-3, peptidylarginine deiminase, phosphorylation, mouse, oocyte maturation, gamete biology. Includes bibliographical references (p. 91-97).

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Duval, Manuel. "La semence et la biotine : découverte d'une protéine à biotine chez Pisum sativum L., marqueur moléculaire de la maturation des semences et des phases précoces de la germination." Grenoble 1, 1995. http://www.theses.fr/1995GRE10133.

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L'etat de vie ralentie caracterise la semence orthodoxe des spermaphytes. Cet etat, induit au cours de la maturation, est leve pendant la germination. La biotine est une molecule necessaire a toute forme de vie. Le mecanisme moleculaire determinant l'etat de vie ralentie est encore inconnu. La biotine peut-elle intervenir dans ce phenomene biologique ? cette these tend a le demontrer. La biotine est decrite comme etant le cofacteur d'enzymes catalysant des reactions de carboxylations. Or, dans les cellules de tous les organes de la plante et a tout moment de son cycle, la biotine libre est en

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37

Lebrette, Hugo. "Etude structurale de l'import de nickel par les protéines extracytoplasmiques de systèmes ABC chez les bactéries : le nickel voyage-t-il seul ou accompagné ?" Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENV086.

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Chez les procaryotes, les systèmes ABC (ATP-binding cassette) canoniques permettent un import efficace et de haute affinité du nickel, en grande partie via l'action de la Ni-BP (nickel-binding protein) qui va jouer le rôle de récepteur extracytoplasmique du nickel avant son passage à travers la membrane interne. Dans ces travaux, nous avons cherché à mieux caractériser les stratégies d'import de nickel par les bactéries, notamment par l'étude cristallographique des Ni-BP. La résolution des structures de cinq de ces protéines, en interaction avec du nickel, nous a permis d'identifier les sites

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38

Lachance, Véronik. "L’association du récepteur β2-Adrénergique (β2AR) avec les protéines RGGT et HACE1 module son trafic intracellulaire en régulant les mécanismes de maturation et d’activation de la protéine Rab11a". Thèse, Université de Sherbrooke, 2014. http://savoirs.usherbrooke.ca/handle/11143/160.

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Résumé : L’expression de surface des récepteurs couplés aux protéines G (GPCRs) est un processus hautement régulé et très important dans le maintien de l’homéostasie cellulaire. En effet, un déséquilibre dans leur niveau d’expression est souvent relié à différentes pathologies comme le cancer, le diabète, l’obésité, les maladies cardiovasculaires et les maladies neurodégénératives. C’est pourquoi la compréhension des mécanismes moléculaires influençant ce phénomène est si importante et nous permettra d’élaborer et/ou d’améliorer les médicaments ciblant la régulation de ce processus. Il est

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39

Basse, Vincent. "Fine tuning of the respiratory syncytial virus nucleoprotein by post-translational modifications and cellular proteins." Electronic Thesis or Diss., université Paris-Saclay, 2025. http://www.theses.fr/2025UPASL024.

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Le virus respiratoire syncytial (VRS) est le principal agent responsable d'infections aigües des voies respiratoires basses chez les jeunes enfants, ainsi que d'infections respiratoires sévères chez les personnes âgées et immunodéprimés. Depuis 2023, trois vaccins dédiés aux personnes âgées et/ou femmes enceintes sont commercialisés. Pour les jeunes enfants, des traitements préventifs à base d'anticorps monoclonaux sont disponibles. Toutefois, ces stratégies n'induisent qu'une immunité à courte terme, et aucune option thérapeutique antivirale n'est disponible. Appartenant à l'ordre des Mononeg

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40

Seaayfan, Elie. "Régulation du contrôle de qualité de NKCC2 par les interactions protéine-protéine." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB026.

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Le co-transporteur Na+-K+-2Cl- spécifique du rein et sensible au bumétanide, NKCC2, joue un rôle essentiel dans l’homéostasie hydro-électrolytique et acido-basique de l’organisme. Les mutations inactivatrices de NKCC2 induisent le syndrome de Bartter anténatal de type 1, une grave maladie rénale caractérisée par une hypotension artérielle associée à des anomalies électrolytiques. À l’opposé, une activité accrue de NKCC2 est associée à une hypertension artérielle sensible au sel. Pourtant, peu est connu sur la régulation moléculaire de NKCC2. Le but de ces travaux de thèse a donc été l’identifi

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41

Puccio, François. "Influence de l'hydrocortisone, de l'egf, de la bombesine et du grf sur la proliferation cellulaire et la maturation du tractus gastrointestinal et du pancreas chez le jeune rat non sevre." Paris 6, 1988. http://www.theses.fr/1988PA066497.

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Wang, Jing. "Function of protein kinase A in Xenopus oocyte maturation." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/29377.

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Like most other vertebrate oocytes, oocytes from Xenopus laevis are physiologically arrested at the first meiotic prophase. Re-initiation of meiosis, or oocyte maturation, is triggered by progesterone. Progesterone-induced oocyte maturation is thought to involve inhibition of cAMP-dependent protein kinase (protein kinase A or PKA). However, changes in PKA activity in live oocytes have never been demonstrated. I have developed a novel approach to monitor endogenous PKA activity in live oocytes, by expressing a PKA-specific substrate in oocytes followed by monitoring its PKA phosphorylation sta

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43

Grahl, Sabine. "Tat signal peptide recognition during protein maturation and export." Thesis, University of Dundee, 2011. https://discovery.dundee.ac.uk/en/studentTheses/d306d17d-931d-4313-8f91-5a5108fb2256.

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Nitrogen is one of the most abundant elements on Earth and mostly found in the atmosphere as the inert gas N2. Therefore the nitrogen cycle is important for maintaining the bioavailabilty of nitrogen for organisms. Denitrification is a process that closes the nitrogen cycle by subsequent conversion of nitrate to dinitrogen with reduction of nitrate to nitrite being the very first necessary step. The bacterial periplasmic nitrate reductase NapA is one of those nitrate reducing enzymes and contains a molybdenum cofactor and a [4Fe-4S] cluster as cofactors. As a periplasmic terminal reductase Nap

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Martin, Niall M. B. "Protein turnover in Salmonids : sexual maturation and hormonal control." Thesis, University of Aberdeen, 1990. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU548688.

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Aspects of tissue protein metabolism were studied in different groups of Atlantic salmon (Salmo salar). Firstly, 2 groups of sea water salmon were fasted for 3 and 5 days, prior to the measurement of tissue fractional rates of protein synthesis (ks, %day), using the method of 3H-phenylalanine flooding. The sensitivity of liver and gill to a short-term fast was indicated by their reduced rates of ks, while in other tissues such as ventricle, stomach and red muscle protein synthesis was unaffected. Both liver and gill are tissues which show the greatest capacities to synthesise protein, expresse

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Sheng, Yinglun. "G protein signaling and G protein coupled receptor (GPCR) pathway in Xenopus oocyte maturation." Thesis, University of Ottawa (Canada), 2005. http://hdl.handle.net/10393/29262.

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Xenopus laevis oocytes are physiologically arrested at the first meiotic prophase. Progesterone reinitiates meiosis (maturation) through inhibition of an oocyte adenylyl cyclase (AC) and reduction of intracellular cAMP. However, the mechanism by which progesterone regulates AC activity and cAMP level still remains unclear. In this thesis, I summarize work I conducted that collectively helps elucidate how high levels of cAMP might be achieved in G2 arrested oocytes. In Chapter 2, I describe our finding that inhibiting endogenous G-protein betagamma subunits, through the use of two structurally

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46

Morrison, Donna Lorraine. "Identification and characterization of a maturation-inhibited protein kinase (MIPK)." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq27206.pdf.

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Mathew, Anu. "Selective loss of protein and exosome formation during erythroid maturation." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28838.

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Vesicle (exosome) externalization is a mechanism for removal of obsolescent membrane proteins, such as the transferrin receptor (TFR), during reticulocyte maturation. This thesis involves further characterization of the exosomal phenomenon using avian (nucleated) and mammalian erythroid systems. Chicken reticulocytes release exosomes, indicating independence of this process from enucleation. Exosome release during chicken erythroleukemic cell (HD3) differentiation (representing pre-reticulocyte development) demonstrates that this process commences prior to the reticulocyte stage.<br>The heat s

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48

Blain, Françoise 1966. "Studies on the maturation of the measles virus hemagglutinin protein." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59946.

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The hemagglutinin glycoprotein (HA) encoded by measles virus (MV) is a type II integral membrane protein that is expressed at the infected cell surface. The maturation of HA was studied in infected Vero cells. HA oligomerized into a disulfide-linked homodimer with a t$ sb{1/2}$ of 30 min. The rate of transport of HA to the medial Golgi complex was also examined using endoglycosidase-H and found to occur with a t$ sb{1/2}$ of 2 hr. Genes encoding two mutant HA proteins shortened at their C-terminal end by either 18 (HA$ Delta$18) or 223 (HA$ Delta$223) amino acids were constructed and studied i

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Handley, Matthew. "Mitogen-activated protein kinases in dendritic cell maturation and death." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446249/.

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Dendritic cells (DC) sense infection in their microenvironment and undergo a dynamic process of changes in phagocytic capacity, morphology and migratory activity in order to induce optimum T cell immunity. The acquisition of these properties is termed "DC maturation". In this study, key selected aspects of this DC maturation process have been explored. One aspect of DC maturation is the signalling pathways that DC use to respond to micro-environmental signals. DC respond to conserved microbial structures in their micro-environment via pattern recognition receptors including Toll-like receptors

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LISI, GAIA. "Spinster is an Ambra1 interacting protein required for autophagosome maturation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/202447.

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Autophagy is a self-degradative process involved in the turnover of cellular components in response to nutrient starvation or to organelle damage. During this process, portions of cytoplasm are sequestered by double-membrane vesicles, the autophagosomes, and degraded after fusion with lysosomes. Different protein complexes participate to autophagosome formation including various components of the class III phosphatidylinositol-3-OH kinase complex (Ambra1, Beclin 1, Vps34, Vps15, UVRAG) and most of the Atg genes. Here, I show that Ambra1 also plays a role in the regulation of the late steps of

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