Artículos de revistas sobre el tema "Protein targeted lead molecule"
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Hyun, Soonsil y Dongyun Shin. "Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases". Life 11, n.º 7 (24 de junio de 2021): 607. http://dx.doi.org/10.3390/life11070607.
Texto completoGiardina, Sarah F., Elena Valdambrini, Michael Peel, Manny D. Bacolod, Mace L. Rothenberg, Richard B. Lanman, J. David Warren y Francis Barany. "Cure-PROs: Next-generation targeted protein degraders." Journal of Clinical Oncology 41, n.º 16_suppl (1 de junio de 2023): e15101-e15101. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15101.
Texto completoMusielak, Bogdan, Weronika Janczyk, Ismael Rodriguez, Jacek Plewka, Dominik Sala, Katarzyna Magiera-Mularz y Tad Holak. "Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions". Molecules 25, n.º 13 (1 de julio de 2020): 3017. http://dx.doi.org/10.3390/molecules25133017.
Texto completoThomas, Bedwyr ab Ion, H. Lois Lewis, D. Heulyn Jones y Simon E. Ward. "Central Nervous System Targeted Protein Degraders". Biomolecules 13, n.º 8 (25 de julio de 2023): 1164. http://dx.doi.org/10.3390/biom13081164.
Texto completoDas, Debanu, Matthew Duncton, Patricia Pellicena, Ashley Deacon, David Wilson y Millie Georgiadis. "Development of a DNA damage response (DDR) therapeutics platform for oncology." Journal of Clinical Oncology 39, n.º 15_suppl (20 de mayo de 2021): e15036-e15036. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e15036.
Texto completoMilosevic, Ivana. "Resistance to targeted therapy in chronic lymphocytic leukemia". Medical review 75, Suppl. 1 (2022): 57–61. http://dx.doi.org/10.2298/mpns22s1057m.
Texto completoQokoyi, Ndibonani Kebonang, Priscilla Masamba y Abidemi Paul Kappo. "Proteins as Targets in Anti-Schistosomal Drug Discovery and Vaccine Development". Vaccines 9, n.º 7 (8 de julio de 2021): 762. http://dx.doi.org/10.3390/vaccines9070762.
Texto completoOlsen, Sarah Naomi, Laura Godfrey, James P. Healy, Charles Hatton y Scott A. Armstrong. "Abstract 681: Targeted MLL-AF9 degradation is phenocopied by combined DOT1L and Menin inhibition". Cancer Research 82, n.º 12_Supplement (15 de junio de 2022): 681. http://dx.doi.org/10.1158/1538-7445.am2022-681.
Texto completoKhattri, Ram B., Daniel L. Morris, Stephanie M. Bilinovich, Erendra Manandhar, Kahlilah R. Napper, Jacob W. Sweet, David A. Modarelli y Thomas C. Leeper. "Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead". Molecules 25, n.º 1 (30 de diciembre de 2019): 147. http://dx.doi.org/10.3390/molecules25010147.
Texto completoYang, Kylie, Jacek L. Kolanowski y Elizabeth J. New. "Mitochondrially targeted fluorescent redox sensors". Interface Focus 7, n.º 2 (6 de abril de 2017): 20160105. http://dx.doi.org/10.1098/rsfs.2016.0105.
Texto completoLi, Yan, Yi Jia, Xiao-Lin Wang, Hai Shang y Yu Tian. "Protein-Targeted Degradation Agents Based on Natural Products". Pharmaceuticals 16, n.º 1 (28 de diciembre de 2022): 46. http://dx.doi.org/10.3390/ph16010046.
Texto completoRayevsky, O. V., O. M. Demchyk, P. A. Karpov, S. P. Ozheredov, S. I. Spivak, A. I. Yemets y Ya B. Blume. "Structure-based virtual screening for new lead compounds targeted Plasmodium α-tubulin". Faktori eksperimental'noi evolucii organizmiv 28 (31 de agosto de 2021): 135–39. http://dx.doi.org/10.7124/feeo.v28.1389.
Texto completoRoos, Martina M., Michelle Li, Pang Amara y John P. Chute. "Pharmacologic Targeting of LIN28/Let-7 in Acute Myeloid Leukemia". Blood 132, Supplement 1 (29 de noviembre de 2018): 4072. http://dx.doi.org/10.1182/blood-2018-99-119982.
Texto completoAngelbello, Alicia J., Suzanne G. Rzuczek, Kendra K. Mckee, Jonathan L. Chen, Hailey Olafson, Michael D. Cameron, Walter N. Moss, Eric T. Wang y Matthew D. Disney. "Precise small-molecule cleavage of an r(CUG) repeat expansion in a myotonic dystrophy mouse model". Proceedings of the National Academy of Sciences 116, n.º 16 (29 de marzo de 2019): 7799–804. http://dx.doi.org/10.1073/pnas.1901484116.
Texto completoSchäfer, Mirijam, Marie Luise Semmler, Thoralf Bernhardt, Tobias Fischer, Vinodh Kakkassery, Robert Ramer, Martin Hein et al. "Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins". Cancers 13, n.º 8 (7 de abril de 2021): 1770. http://dx.doi.org/10.3390/cancers13081770.
Texto completoShen, Jingshi, Eric Davis y Charles Dinarello. "Haploid genetic dissection of immune molecule trafficking (TECH1P.836)". Journal of Immunology 192, n.º 1_Supplement (1 de mayo de 2014): 69.4. http://dx.doi.org/10.4049/jimmunol.192.supp.69.4.
Texto completoChen, Jianlin, Xiaorong Liu y Jianhan Chen. "Targeting Intrinsically Disordered Proteins through Dynamic Interactions". Biomolecules 10, n.º 5 (11 de mayo de 2020): 743. http://dx.doi.org/10.3390/biom10050743.
Texto completoYin, Xiaoyan, Subha Subramanian, Shih-Jen Hwang, Christopher J. O’Donnell, Caroline S. Fox, Paul Courchesne, Pieter Muntendam et al. "Protein Biomarkers of New-Onset Cardiovascular Disease". Arteriosclerosis, Thrombosis, and Vascular Biology 34, n.º 4 (abril de 2014): 939–45. http://dx.doi.org/10.1161/atvbaha.113.302918.
Texto completoBeaton, Nigel, Roland Bruderer, Yuehan Feng, Jagat Adhikari, Ivan Cornella-Taracido y Lukas Reiter. "Abstract 2024: High resolution limited proteolysis (HR-LiP), a novel structural proteomics approach for the prediction of small molecule-protein binding events". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 2024. http://dx.doi.org/10.1158/1538-7445.am2023-2024.
Texto completoAjay, Amrendra K., Philip Chu, Poojan Patel, Christa Deban, Chitran Roychowdhury, Radhika Heda, Ahmad Halawi et al. "High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma". Pharmaceutics 15, n.º 4 (18 de abril de 2023): 1274. http://dx.doi.org/10.3390/pharmaceutics15041274.
Texto completoKanakaveti, V., P. Anoosha, R. Sakthivel, S. K. Rayala y M. M. Gromiha. "Influence of Amino Acid Mutations and Small Molecules on Targeted Inhibition of Proteins Involved in Cancer". Current Topics in Medicinal Chemistry 19, n.º 6 (2 de mayo de 2019): 457–66. http://dx.doi.org/10.2174/1568026619666190304143354.
Texto completoSanthaKumari, Subha Lakshmi Gopalakrishnan Nair y Samuel GnanaPrakash Vincent. "Identification and molecular characterization of drug targets of methicillin resistant Staphylococcus aureus". Journal of Applied and Natural Science 14, n.º 4 (19 de diciembre de 2022): 1152–57. http://dx.doi.org/10.31018/jans.v14i4.3693.
Texto completoHanajima-Ozawa, Miyuki, Takeshi Matsuzawa, Aya Fukui, Shigeki Kamitani, Hiroe Ohnishi, Akio Abe, Yasuhiko Horiguchi y Masami Miyake. "Enteropathogenic Escherichia coli, Shigella flexneri, and Listeria monocytogenes Recruit a Junctional Protein, Zonula Occludens-1, to Actin Tails and Pedestals". Infection and Immunity 75, n.º 2 (21 de noviembre de 2006): 565–73. http://dx.doi.org/10.1128/iai.01479-06.
Texto completoSalha M Tawati, Aisha A Alsfouk y Asma Alsarrah. "Homology modelling and molecular docking study of TMPRSS2 with small-molecule protease inhibitors to control SARS-CoV-2". International Journal of Research in Pharmaceutical Sciences 13, n.º 2 (19 de abril de 2022): 201–10. http://dx.doi.org/10.26452/ijrps.v13i2.190.
Texto completoBonilla, Francisco A. "Personalized therapy for common variable immunodeficiency". Allergy and Asthma Proceedings 41, n.º 1 (1 de enero de 2020): 19–25. http://dx.doi.org/10.2500/aap.2020.41.190012.
Texto completoFricke, Doerte Raphaela, Gang Liu, Hyejin Kim, Pingyuan Wang, Xi Liu, Haiying Chen, Ruixia Ma, Junhai Xu, Jia Zhou y Qiang Shen. "Abstract 3940: Novel Bax activators for targeted breast cancer therapy". Cancer Research 82, n.º 12_Supplement (15 de junio de 2022): 3940. http://dx.doi.org/10.1158/1538-7445.am2022-3940.
Texto completoSavva, Loukiani y Savvas N. Georgiades. "Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes". Molecules 26, n.º 4 (5 de febrero de 2021): 841. http://dx.doi.org/10.3390/molecules26040841.
Texto completoSmith, Kathryn, Andrea Lopez-Arroyo, Jason Berk, Peter Hegan, Peter Nower, Samantha Tice, Aurelie Moutran et al. "Abstract PR09: KRAS-targeted PROTAC degraders are broadly efficacious against KRAS-dependent tumor models". Molecular Cancer Research 21, n.º 5_Supplement (1 de mayo de 2023): PR09. http://dx.doi.org/10.1158/1557-3125.ras23-pr09.
Texto completoSimard, Jeffrey R., Linda Lee, Ellen Vieux, Reina Improgo, Trang Tieu, Andrew J. Phillips, Stewart L. Fisher, Roy M. Pollock y Eunice Park. "High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics". SLAS DISCOVERY: Advancing the Science of Drug Discovery 26, n.º 4 (11 de enero de 2021): 503–17. http://dx.doi.org/10.1177/2472555220985049.
Texto completoShuttleworth, Stephen, Richard Connors, Jiasheng Fu, Jinqian Liu, Mike Lizarzaburu, Wei Qiu, Rajiv Sharma, Malgorzata Wanska y Alex Zhang. "Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization". Current Medicinal Chemistry 12, n.º 11 (1 de junio de 2005): 1239–81. http://dx.doi.org/10.2174/0929867054020936.
Texto completoYunes, Sarah A., Jennifer L. S. Willoughby, Julian H. Kwan, Jessica M. Biagi, Niranjana Pokharel, Hang Gyeong Chin, Emily A. York et al. "Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins". PLOS ONE 17, n.º 6 (15 de junio de 2022): e0268857. http://dx.doi.org/10.1371/journal.pone.0268857.
Texto completoKeefe, Anthony D., Jeremy S. Disch, Jennifer Duffy, Esther C. Lee, Diana Gikunju, Betty Chan, Benjamin D. Levin et al. "Abstract 5346: Discovery of new targeted protein degraders using DNA-encoded chemistry". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 5346. http://dx.doi.org/10.1158/1538-7445.am2023-5346.
Texto completoOgino, Fedorov, Adams, Okada, Ito, Sugiyama y Ogino. "Vesiculopolins, a New Class of Anti-Vesiculoviral Compounds, Inhibit Transcription Initiation of Vesiculoviruses". Viruses 11, n.º 9 (14 de septiembre de 2019): 856. http://dx.doi.org/10.3390/v11090856.
Texto completoKelleher, Joseph, Laurent Audoly, Veronica Campbell, Jesse Chen, Nan Ji, Hari Kamadurai, Henry Li et al. "Targeted Degradation of IRAK4 Protein Via Heterobifunctional Small Molecules for Treatment of MYD88 Mutant Lymphoma". Blood 132, Supplement 1 (29 de noviembre de 2018): 2953. http://dx.doi.org/10.1182/blood-2018-99-120148.
Texto completoDa Silva, Gustavo F., Alex Ghetu, Leandro Cerchietti, Jose M. Polo, Andrew Coop, Alexander Mackerell, Gilbert G. Prive y Ari Melnick. "Design and Development of Small Molecules for Specific Targeted Therapy of Diffuse Large B-Cell Lymphoma." Blood 110, n.º 11 (16 de noviembre de 2007): 799. http://dx.doi.org/10.1182/blood.v110.11.799.799.
Texto completoD’Annessa, Ilda, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero et al. "Design of Disruptors of the Hsp90–Cdc37 Interface". Molecules 25, n.º 2 (15 de enero de 2020): 360. http://dx.doi.org/10.3390/molecules25020360.
Texto completoPattenden, Samantha G., Jeremy M. Simon, Aminah Wali, Chatura N. Jayakody, Jacob Troutman, Andrew W. McFadden, Joshua Wooten et al. "High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility". Proceedings of the National Academy of Sciences 113, n.º 11 (29 de febrero de 2016): 3018–23. http://dx.doi.org/10.1073/pnas.1521827113.
Texto completoRanganathan, Santhalakshmi, Alexander Kornienko, Antonio Evidente, Daniel Romo y Joseph Taube. "Abstract 6153: Triple negative breast cancer targeted by Ophiobolin A: Epithelial-mesenchymal transition take the lead". Cancer Research 83, n.º 7_Supplement (4 de abril de 2023): 6153. http://dx.doi.org/10.1158/1538-7445.am2023-6153.
Texto completoKelly, Aileen, Daniel W. Robbins, May Tan, Austin Tenn-McClellan, Joel McIntosh, Jeffrey Wu, Zef Konst et al. "Targeted Protein Degradation of BTK As a Unique Therapeutic Approach for B Cell Malignancies". Blood 134, Supplement_1 (13 de noviembre de 2019): 3805. http://dx.doi.org/10.1182/blood-2019-129262.
Texto completoKuroki, K., R. Russnak y D. Ganem. "Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum". Molecular and Cellular Biology 9, n.º 10 (octubre de 1989): 4459–66. http://dx.doi.org/10.1128/mcb.9.10.4459-4466.1989.
Texto completoYosaatmadja, Yuliana, Adam Vorn Patterson, Jeff Bruce Smaill y Christopher John Squire. "The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition". Acta Crystallographica Section D Biological Crystallography 71, n.º 3 (26 de febrero de 2015): 525–33. http://dx.doi.org/10.1107/s1399004714027539.
Texto completoKuroki, K., R. Russnak y D. Ganem. "Novel N-terminal amino acid sequence required for retention of a hepatitis B virus glycoprotein in the endoplasmic reticulum." Molecular and Cellular Biology 9, n.º 10 (octubre de 1989): 4459–66. http://dx.doi.org/10.1128/mcb.9.10.4459.
Texto completoXia, Yuxing, Grace M. Lloyd y Benoit I. Giasson. "Targeted proteolytic products of τ and α-synuclein in neurodegeneration". Essays in Biochemistry 65, n.º 7 (diciembre de 2021): 905–12. http://dx.doi.org/10.1042/ebc20210028.
Texto completoFranco, Rafael, Vicent Casadó, Antoni Cortés, Carla Ferrada, Josefa Mallol, Amina Woods, Carme Lluis, Enric I. Canela y Sergi Ferré. "Basic Concepts in G-Protein-Coupled Receptor Homo- and Heterodimerization". Scientific World JOURNAL 7 (2007): 48–57. http://dx.doi.org/10.1100/tsw.2007.197.
Texto completoStrasser, Jane E., Monica Arribas, Anastasia D. Blagoveshchenskaya y Daniel F. Cutler. "Secretagogue-triggered Transfer of Membrane Proteins from Neuroendocrine Secretory Granules to Synaptic-like Microvesicles". Molecular Biology of the Cell 10, n.º 8 (agosto de 1999): 2619–30. http://dx.doi.org/10.1091/mbc.10.8.2619.
Texto completoKarwasra, Ritu, Shaban Ahmad, Nagmi Bano, Sahar Qazi, Khalid Raza, Surender Singh y Saurabh Varma. "Macrophage-Targeted Punicalagin Nanoengineering to Alleviate Methotrexate-Induced Neutropenia: A Molecular Docking, DFT, and MD Simulation Analysis". Molecules 27, n.º 18 (16 de septiembre de 2022): 6034. http://dx.doi.org/10.3390/molecules27186034.
Texto completoRampogu, Shailima y Mary Rampogu Lemuel. "Network Based Approach in the Establishment of the Relationship between Type 2 Diabetes Mellitus and Its Complications at the Molecular Level Coupled with Molecular Docking Mechanism". BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6068437.
Texto completoZhou, Dan, Yuan Liu, Josephine Ye, Weiwen Ying, Dinesh Chimmanamada, Luisa Shin Ogawa, Takayo Inoue, Patricia Rao y Yumiko Wada. "Potent anti-inflammatory activity of a novel of class Hsp90 inhibitors for multiple sclerosis (51.1)". Journal of Immunology 188, n.º 1_Supplement (1 de mayo de 2012): 51.1. http://dx.doi.org/10.4049/jimmunol.188.supp.51.1.
Texto completoBonami, Rachel, Lindsay Nyhoff, Chrys Hulbert, Jamie Felton, Peggy L. Kendall y James W. Thomas. "One size doesn’t fit all: SLAM-Associated Protein is dispensable for type 1 diabetes but required for autoantibody-mediated arthritis". Journal of Immunology 202, n.º 1_Supplement (1 de mayo de 2019): 115.14. http://dx.doi.org/10.4049/jimmunol.202.supp.115.14.
Texto completoZuo, Jun, Steve Kye, Kevin K. Quinn, Paige Cooper, Robert Damoiseaux y Paul Krogstad. "Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses". Antimicrobial Agents and Chemotherapy 60, n.º 3 (28 de diciembre de 2015): 1615–26. http://dx.doi.org/10.1128/aac.02646-15.
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