Literatura académica sobre el tema "Premature ageing"
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Artículos de revistas sobre el tema "Premature ageing"
Villanueva, M. Teresa. "Slowing premature ageing". Nature Reviews Cancer 15, n.º 5 (24 de abril de 2015): 259. http://dx.doi.org/10.1038/nrc3956.
Texto completoJoss, Nicola, J. Michael Boulton‐Jones y Ian More. "Premature ageing and glomerulonephritis". Nephrology Dialysis Transplantation 16, n.º 3 (1 de marzo de 2001): 615–18. http://dx.doi.org/10.1093/ndt/16.3.615.
Texto completoSmith, Michael. "Premature Ageing: History and Biology". Journal of the Royal Society of Medicine 87, n.º 7 (julio de 1994): 425–27. http://dx.doi.org/10.1177/014107689408700720.
Texto completoBiesalski, H. K., M. Berneburg, T. Grune, M. Kerscher, J. Krutmann, W. Raab, J. Reimann, T. Reuther, L. Robert y T. Schwarz. "Oxidative and premature skin ageing". Experimental Dermatology 12, s3 (diciembre de 2003): 3–15. http://dx.doi.org/10.1111/j.0906-6705.2003.00148.x.
Texto completoDokal, Inderjeet. "A disease of premature ageing". Lancet 358 (diciembre de 2001): S27. http://dx.doi.org/10.1016/s0140-6736(01)07040-4.
Texto completoSilverstein, Janet H. "Does diabetes cause premature AGEing?" Journal of Pediatrics 172 (mayo de 2016): 1–4. http://dx.doi.org/10.1016/j.jpeds.2016.03.011.
Texto completoTestori, Alessandro. "Short telomere syndromes, premature ageing syndromes, and biological ageing". Hong Kong Medical Journal 26, n.º 1 (22 de enero de 2020): 76–77. http://dx.doi.org/10.12809/hkmj187782.
Texto completoLehmann, Alan. "Ageing: Repair and Transcription Keep Us from Premature Ageing". Current Biology 12, n.º 16 (agosto de 2002): R550—R551. http://dx.doi.org/10.1016/s0960-9822(02)01050-3.
Texto completoDYER, CHRISTOPHER A. E. y ALAN J. SINCLAIR. "The premature ageing syndromes: insights into the ageing process". Age and Ageing 27, n.º 1 (1998): 73–80. http://dx.doi.org/10.1093/ageing/27.1.73.
Texto completoSwanton, Alexander y Tim Child. "Reproduction and ovarian ageing". British Menopause Society Journal 11, n.º 4 (1 de diciembre de 2005): 126–31. http://dx.doi.org/10.1258/136218005775544200.
Texto completoTesis sobre el tema "Premature ageing"
Mankouri, Hocine William. "DNA helicases and yeast ageing". Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367550.
Texto completoChau, P. Y. Pauline. "Mechanism of genomic instability in Prelamin A based premature ageing". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557352.
Texto completoChau, P. Y. Pauline y 周珮然. "Mechanism of genomic instability in Prelamin A based premature ageing". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557352.
Texto completoSeager, Anna L. "Molecular and cytogenetic analysis of premature ageing disease Hutchinson-Gilford Progeria Syndrome". Thesis, Swansea University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.638787.
Texto completoChan, Wing Lee [Verfasser]. "Molecular basis of Gerodermia Osteodysplastica, a premature ageing disorder / Wing Lee Chan". Berlin : Freie Universität Berlin, 2014. http://d-nb.info/1046312812/34.
Texto completoLees, Hayley Diane. "Molecular mechanisms of premature ageing in a worm model of human Werner syndrome". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:080df619-828b-4248-b03f-c4aeb31f1672.
Texto completoWredenberg, Anna. "Mitochondrial dysfunction in ageing and degenerative disease /". Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-311-5/.
Texto completoChapko, Dorota. "Life-course determinants of resilience to cognitive ageing : empirical evidence and policy implications". Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230978.
Texto completoFontes, Larissa. "Análise da expressão do gene FMR1 no ovário". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-25042012-102756/.
Texto completoThis study aimed at investigating the FMR1 gene (Fragile X Mental Retardation gene 1), regarding its relationship with primary ovarian insufficiency (Fragile X-related Primary Ovarian Insufficiency, FXPOI). In Chapter I, we present a literature review on FXPOI. The FMR1 premutation is the most frequent genetic cause of predisposition to premature ovary insufficiency (POI) and, among the POI familial cases, about 10% are associated with the FMR1 gene premutation. However, little is known about the gene expression in the mammal ovary, and the mechanisms by which the premutation causes POI remain unknown. Chapter II presents the study of the FMR1 gene expression in the human and murine adult ovaries. The enormous difficulties inherent in obtaining and studying female germ cells led us to study human granulosa cells (HGC), which are easily obtained as byproducts of in vitro fertilization procedures. We also studied the FMR1 expression in granulosa cells of mice of the CD1 strain (MGC), collected from the oviducts after ovulation induction. Granulosa cells interact functionally with oocytes during folliculogenesis, transmitting signals through the ovary and supporting growth and maturation of oocytes during the later stages of follicular growth. It is, therefore, possible that cellular changes induced by the FMR1 premutation in HGCs affect follicular growth, ovulation rate and fecundity. We standardized protocols for isolation and culture of HGCs obtained from follicular fluid and confirmed the origin of the isolated cells by the expression of HGC markers, using RT-PCR, and by the lipid nature of the cytoplasmic granules, as demonstrated by the staining with the lipophilic dye DiI. We demonstrated, by RT-PCR, that HGCs isolated from follicular fluid express the FMR1 mRNA. In mice, also by RT-PCR, we detected the Fmr1 mRNA in oocytes and in the MGCs, collected from the oviduct after ovulation hyperstimulation. Using RNA in situ hybridization on cultured HCGs, we detected the FMR1 mRNA dispersed in the cytoplasm and, in the nucleus, concentrated in regions whose features indicated to be nucleoli. This same distribution was observed in cultured fibroblasts. This probable nucleolar localization of the FMR1 transcript in these cells suggests that it constitutes messenger ribonucleoproteins for further targeting to specific cytoplasmic sites where translation occurs. We verified, by Western blotting, that HGCs express high levels of the main FMRP isoforms, with molecular mass between 60 and 95 kDa. We determined the FMRP subcellular localization in HGCs and that of Fmrp in MGCs, by immunostaining. The hybridization signals were seen scattered in fine granules in the cytoplasm of both HGCs and MGCs, in a pattern of distribution similar to that observed in neurons. In the MGC filopodia, the protein labeling was concentrated at some sites, similar to the previously described pattern of Fmrp distribution in neuronal dendritic spines of rat hippocampus, where it is part of RNA granules, promoting mRNA transport and translation control. The similar distribution pattern between neurons and MGC may reflect the similarity of FMRP function in both tissues. The induction of oxidative stress in the HGC by treatment with sodium arsenite led the protein to leave its diffuse cytoplasmic distribution to become part of perinuclear stress granules, co-localized with TIA-1, a marker of these structures. Similar results were previously obtained in HeLa cells and in rat hippocampus. These results support the hypothesis that FMRP participates in the mechanism of the transient translation arrest after stress. In Chapter III, we describe our attempts to obtain an embryonic stem cell line (ESC) from knock-in mice (KI) for the FMR1 premutation. To obtain KI embryos, wild females (WT, strain C57) were crossed with males KI (strain C57/BL6), and KI females were crossed with WT males. We planned to compare the expression of the fmr1 gene in the ESCs from the KI and WT strains, including during differentiation. We did not succeed in obtaining an ESC KI line, which can be attributed to difficulties inherent to the procedure. At follow-up of the first four days of in vitro development of embryos, changes in cleavage and developmental arrest were more frequently observed in embryos obtained from KI females. Meanwhile, the average survival rates of oocytes to blastocysts, and 8-16 cell embryos to blastocysts were not statistically different between the KI and WT females. The great variability among the numbers of blastocysts obtained per female and the small size of the KI (six females) and WT (seven females) groups indicate that these results should be interpreted with caution. Immunostaining analysis of the Fmrp in blastocysts showed a probably cytoplasmic distribution, with a granular pattern of labeling, the grains being more common in blastocysts from WT females, but coarser in blastocysts from KI females. These data are suggestive that the Fmr1 premutation in murine females affects the early development of their embryos. This aspect needs further investigation
Urli, Laureline. "Les cellules sénescentes sont-elles des caractéristiques communes à la maladie d'Alzheimer et à l'apnée du sommeil ?" Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS085.pdf.
Texto completoAlzheimer's disease (AD), a neurodegenerative, progressive and incurable diseaseleading to cognitive decline is characterized by extracellular Aβ plaques and intracellular neuronal tau-containing neurofibrillary tangles.Both of these lesions appear in the hippocampus and spread to other regions of the brain. Age is the primary risk factor, but other risk factors such as sleep disorders are also implicated in the development of AD. Obstructive sleep apnea syndrome (OSAS), characterized by sleep fragmentation and intermittent hypoxia (IH), is frequently found in AD patients, and people with OSAS are more prone to developing cognitive disorders and neurodegenerative pathologies. Experimentally, IH induces oxidative stress and neuroinflammation, specially, in the hippocampus, which may lead to and/or be a consequence of cellular senescence and premature aging.In this thesis work, we focused on chronic IH as a potential inducer of senescence in the hippocampus by analyzing senescence markers and the senescence-associated secretory phenotype (SASP) in mice subjected to chronic IH for six weeks. To determine the impact of IH-induced senescence on the development of AD, we also worked on cohorts of PS1Ki mice, AD models.We demonstrate detrimental effects of chronic IH exposure in adult mice by showing impairment in object recognition memory, induction of oxidative stress, and increased markers of cellular senescence and SASP in the hippocampus, particularly in the dentate gyrus and CA3. These effects are age-dependent and neuronal cells appear to be particularly affected by this state of senescence. In PS1Ki mice, alterations, already revealed under normoxic conditions, are exacerbated by chronic IH. Indeed, in addition to being present in the hippocampus, senescent cells accumulate in the entorhinal and prefrontal cortices depending on the age of the mice.Collectively, our results suggest that the process of cellular senescence may be a key factor in the transition from physiological brain ageing to neurodegenerative pathology. Senolytic treatment targeting senescent cells could be considered to improve current OSAS treatments and to prevent premature brain ageing, thereby accelerating the pathophysiology and symptoms of AD
Libros sobre el tema "Premature ageing"
Goodrum, Glen. Premature Ageing: Premature Aging Facts You Wish You Knew. Independently Published, 2019.
Buscar texto completoGoodrum, Glen. Stop or Reverse Premature Ageing: Knowledge Is Golden. Independently Published, 2019.
Buscar texto completoFerreira, Isabel y Jos WR Twisk. Physical activity, cardiorespiratory fitness, and cardiovascular health. Editado por Neil Armstrong y Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0017.
Texto completoRaggi, Paolo y Luis D’Marco. Imaging for detection of vascular disease in chronic kidney disease patients. Editado por David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0116.
Texto completoAbhishek, Abhishek y Michael Doherty. Investigations of calcium pyrophosphate deposition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0051.
Texto completoHunt, Beverley J. Haemostatic agents in critical illness. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0052.
Texto completoCapítulos de libros sobre el tema "Premature ageing"
Toriello, Helga V. "Premature Ageing Syndromes". En Harper's Textbook of Pediatric Dermatology, 134.1–134.19. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444345384.ch134.
Texto completoDebacq-Chainiaux, Florence, Randa Ben Ameur, Emilie Bauwens, Elise Dumortier, Marie Toutfaire y Olivier Toussaint. "Stress-Induced (Premature) Senescence". En Cellular Ageing and Replicative Senescence, 243–62. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26239-0_13.
Texto completoDu, Hong-Yan, Monica Bessler y Philip J. Mason. "Telomerase Mutations and Premature Ageing in Humans". En Telomeres and Telomerase in Ageing, Disease, and Cancer, 77–107. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-73709-4_5.
Texto completoPascual-Castroviejo, Ignacio y Martino Ruggieri. "Progeria and Progeroid Syndromes (Premature Ageing Disorders)". En Neurocutaneous Disorders Phakomatoses and Hamartoneoplastic Syndromes, 847–78. Vienna: Springer Vienna, 2008. http://dx.doi.org/10.1007/978-3-211-69500-5_54.
Texto completoHartwig, W. "Lifespan of Cattle and Horses Under Various Climatic Conditions and the Reasons for Premature Culling". En Ciba Foundation Symposium - The Lifespan of Animals (Colloquia on Ageing, Vol. 5), 57–71. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/9780470715253.ch5.
Texto completoGittenberger-de Groot, Adriana C., Regina Bokenkamp, Vered Raz, Conny van Munsteren, Robert E. Poelmann, Nimrat Grewal y Marco C. DeRuiter. "Progerin Expression during Normal Closure of the Human Ductus Arteriosus: A Case of Premature Ageing?" En Etiology and Morphogenesis of Congenital Heart Disease, 245–51. Tokyo: Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-54628-3_34.
Texto completoZiegenhain, Patrick. "Getting Old Before Getting Rich (and not Fully Realizing It): Premature Ageing and the Demographic Momentum in Southeast Asia". En Global Political Demography, 167–93. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-73065-9_7.
Texto completovan Oostwaard, Marsha y Andréa Marques. "Osteoporosis and the Nature of Fragility Fracture: An Overview". En Perspectives in Nursing Management and Care for Older Adults, 17–34. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-33484-9_2.
Texto completoDe Pauw, Ines, Carolien Boeckx y An Wouters. "Mechanisms of Cetuximab Resistance and How to Overcome It". En Critical Issues in Head and Neck Oncology, 21–51. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_3.
Texto completoDavis, Colin J. y Gerard S. Conway. "Premature ovarian failure and ovarian ageing". En Paediatric and Adolescent Gynaecology, 373–88. Cambridge University Press, 2004. http://dx.doi.org/10.1017/cbo9780511527036.031.
Texto completoActas de conferencias sobre el tema "Premature ageing"
Clements, David y Pierluigi Mancarella. "Risk of cable overheating and premature ageing due to load control measures". En 2017 IEEE Manchester PowerTech. IEEE, 2017. http://dx.doi.org/10.1109/ptc.2017.7981024.
Texto completoWang, Kun, Avinash Das, Zheng-Mei Xiong, Kan Cao y Sridhar Hannenhalli. "Identification of gene clusters with phenotype-dependent expression with application to normal and premature ageing". En BCB'13: ACM-BCB2013. New York, NY, USA: ACM, 2013. http://dx.doi.org/10.1145/2506583.2506652.
Texto completoAljaroudi, Alireda, Premkumar Thodi, Ayhan Akinturk, Faisal Khan y Mike Paulin. "Application of Probabilistic Methods for Predicting the Remaining Life of Offshore Pipelines". En 2014 10th International Pipeline Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/ipc2014-33431.
Texto completoBartonicek, Jaroslav, Lubomir Junek, Milan Vrana y Stanislav Vejvoda. "Safety Approach and Ageing Management in Czech Rules and Standards". En ASME 2009 Pressure Vessels and Piping Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/pvp2009-77653.
Texto completoFan, Zimo, Andrew Steptoe y Olesya Ajnakina. "OP55 The effect of high polygenic propensity for ADHD and socioeconomic factors on increasing timing to premature mortality: evidence from English Longitudinal Study of Ageing". En Society for Social Medicine Annual Scientific Meeting Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jech-2022-ssmabstracts.54.
Texto completoDe Cristofaro, Sarah, Luca Rizzi, Dario Cardone, Lisa Berti y Ubaldo Spina. "Smart Relax Armchair - a solution for active and safe ageing at home". En 15th International Conference on Applied Human Factors and Ergonomics (AHFE 2024). AHFE International, 2024. http://dx.doi.org/10.54941/ahfe1004896.
Texto completoKonrade, Daiga. "Carotenoid extract and oil from pumpkin (cucurbitta spp.) by-products for facial creams with high antioxidant activity". En Research for Rural Development 2023 : annual 29th international scientific conference proceedings. Latvia University of Life Sciences and Technologies, 2023. http://dx.doi.org/10.22616/rrd.29.2023.012.
Texto completoBanerjee, Sarbartha, Rajarshi Maitra, JyotiKamal Das, Abani Satapathy, Tiju Zachariah, Harpreet Singh Sandhu y Jon Wang Abanikumar. "Assessment of River Mersey Steel Truss Bridge Using Non-Linear Finite Element Analysis". En IABSE Symposium, Istanbul 2023: Long Span Bridges. Zurich, Switzerland: International Association for Bridge and Structural Engineering (IABSE), 2023. http://dx.doi.org/10.2749/istanbul.2023.0480.
Texto completoGeurts, J., S. Nasi, T. A. Prolla, G. C. Kujoth, U. A. Walker y T. Hügle. "SAT0071 Subchondral osteopenia but not cartilage damage is prevalent in knee joints of prematurely ageing mitochondrial dna mutator mice". En Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.1065.
Texto completoPrasad, Romesh, Matthew K. Swanson y Young Moon. "Recovering From Cyber-Manufacturing Attacks by Reinforcement Learning". En ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-93982.
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