Literatura académica sobre el tema "Poloxamer 407"

Chronic wounds are a significant and growing health problem, and clinical treatment is often a painful experience. A topical dosage form would be optimal to treat this pain. Poloxamer 407, a thermosensitive polymer that is a liquid at low temperatures but gels at higher temperatures, is well suited to administer topical analgesics to chronic wound sites. The goal of this study was to evaluate the gelation and drug delivery properties of poloxamer 407 gels containing diclofenac sodium for potential use in chronic wound analgesic delivery. The gelation properties of poloxamer formulations were evaluated rheologically. Drug delivery properties of poloxamers loaded with diclofenac sodium were evaluated using snakeskin dialysis membranes, intact porcine ear skin, and porcine ear skin impaired via tape stripping. A commercial gel product and a solution of diclofenac sodium in water were used as control formulations. Poloxamer concentration and gelation temperature varied inversely, and the addition of higher concentrations of diclofenac sodium correlated to significant increases in poloxamer gelation temperature. Poloxamer solutions were effective in limiting the permeation of diclofenac sodium through membranes with impaired barrier properties, and delivery of diclofenac sodium from poloxamer 407 did not vary significantly from delivery observed from the commercial gel product. The amount of drug delivered in 24 h did not change significantly with changes in poloxamer 407 concentration. The results of this study indicate that poloxamer 407 may be a useful formulation component for administration of an analgesic product to a chronic wound site.

In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

Physicochemical characterization of solid dispersion systems of tadalafil with poloxamer 407 Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interactions, a significant decrease in crystallinity and the possibility of existence of amorphous entities of the drug. In the binary systems tested, 1:0.5 proportion of tadalafil/poloxamer 407 showed rapid dissolution of tadalafil (DE30 70.9 ± 3.6 %). In contrast, higher proportions of poloxamer 407 (1:1.5 and 1:2.5) offered no advantage towards dissolution enhancement of the drug, indicating altered rheological characteristics of the polymer at its higher concentration, which might have retarded the release rate of tadalafil.

ABSTRACT An 8 yr old male castrated hound presented for a left distal ulnar osteosarcoma. Staging (computed tomography and nuclear scintigraphy) did not reveal any metastases. A limb-sparing ulnectomy with local adjunctive carboplatin in a poloxamer copolymer gel (poloxamer 407) was performed. The patient recovered without complications after surgery. No wound healing complications or adverse effects occurred after local use of carboplatin in poloxamer 407. The local recurrence-free interval was 296 days from surgery, and the survival time was 445 days from initial diagnosis. This is the first report in the veterinary literature of using poloxamer 407 as a carrier for local delivery of chemotherapeutic drugs in a clinical patient.

Poloxamer 407 exhibits remarkable reversible sol gel transition which makes it attractive and promising in the application of transdermal therapy. This study mainly reports the skin permeation properties of model drug from poloxamer 407 based transdermal hydrogel therapy with the presence of chemical penetration enhancers. Poloxamer 407 based hydrogel was shown porous structure which faciliates the diffusional release of model drug. Compared with borneol and 1,2-propanediol, azone was the most effective enhancer for gallic acid skin permeation, and 3% of azone presented the optimal enhancement effect. This study also demonstrated that the selection of enhancers is of great importance for the skin permeation of model drug.

O nimodipino é um bloqueador de canais de cálcio usado principalmente na terapia da hemorragia subaracnóidea e no tratamento de distúrbios cognitivos. É praticamente insolúvel em água e, pelo Sistema de Classificação Biofarmacêutica (SCB), é qualificado como classe II e, portanto, sua dissolução é etapa limitante da absorção, podendo apresentar problemas de biodisponibilidade. Assim, o objetivo do trabalho foi desenvolver e caracterizar dispersões sólidas de nimodipino, obtidas com os carreadores PEG 6000 ou Poloxamer 407 e compará-las quanto à melhoria na solubilidade e na dissolução do nimodipino. As dispersões sólidas foram obtidas pelos métodos de fusão e de evaporação do solvente e foram caracterizadas pelas técnicas de calorimetria exploratória diferencial (DSC), espectroscopia de absorção na região do infravermelho (FT-IR) e difração de raios-X, cujos resultados comprovaram a obtenção das dispersões sólidas. As características de solubilidade e de dissolução do nimodipino nas dispersões sólidas e em misturas físicas foram comparadas. As dispersões sólidas contendo poloxamer 407 apresentaram maior eficiência em melhorar a solubilidade e a velocidade de dissolução do nimodipino, o que pode ser explicado pelo seu efeito tensoativo. O aumento da solubilidade das dispersões sólidas preparadas com PEG (DSPEG-10 = 13,2 g.mL-1) foi significativamente maior que aquele devido às misturas físicas de mesma composição (MFPEG-10 = 3,21 g.mL-1) que, por sua vez, apresentaram solubilidade maior que a do fármaco (2,19 g.mL-1). O mesmo ocorreu com a eficiência de dissolução dessas preparações (DSPEG-10 = 69,11% , MFPEG-10 = 15,61% e nimodipino = 11,68%). Maior incremento da solubilidade foi obtido com a dispersão sólida produzida pelo método de evaporação do solvente contendo poloxamer 407 como carreador (SOLVP407-10 = 75,61 g.mL-1).
Nimodipine is a calcium blocker, used in prevention and treatment of ischaemic neurological deficits after aneurismal subarachnoid hemorrhage and cognitive deficit. It exhibits a low solubility in water and it is classified as class two in the Biopharmaceutics Classification System (BCS), thereby dissolution is the ratelimiting step in absorption, which impact on bioavailability. Consequently, the objective of this study was to develop and characterize solid dispersions of nimodipine, prepared with PEG 6000 or Poloxamer 407 and to compare them in terms of nimodipine solubility and dissolution. Solid dispersions were obtained by fusion and solvent methods and they were characterized by differential scanning calorimetry (DSC), infra red spectroscopy (FT-IR) and X-ray diffraction, where results confirmed the formation of solid dispersions. Solubility and dissolution characteristics of nimodipine in solid dispersions and physical mixtures were compared. Solid dispersions containing poloxamer 407 showed better efficiency than PEG in increasing solubility and dissolution rate of nimodipine, and it can be explained due to its surfactant activity. The solubility results obtained with solid dispersions prepared with PEG 6000 (DSPEG-10 = 13,2 g.mL-1) were better than physical mixtures with the same composition (MFPEG-10 = 3,21 g.mL-1) which, in turn, showed increased solubility compared with nimodipine (2,19 g.mL-1). Similar results were observed for dissolution efficiency (DSPEG-10 = 69,11% , MFPEG-10 = 15,61% and nimodipine = 11,68%). The best solubility result was obtained by the formulation prepared by the solvent method with poloxamer 407 as carrier (SOLVP407-10 = 75,61 g.mL-1).

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The ferulic acid has antioxidant, anti-inflammatory, antithrombotic, anticancer, neuroprotective, cardioprotective and photoprotective activity. However, despite these biological activities, its therapeutic usefulness is limited due to certain unfavorable physicochemical properties, especially the low aqueous solubility. It is classified as a Class II drug by the Biopharmaceutical Classification System and therefore its dissolution is a limiting step of absorption, may present bioavailability problems. Thus, considering the large number of pharmacological properties attributed to ferulic acid, the aim of this study was to develop and characterize solid dispersions containing ferulic acid, hydrophobic, a non-ionic surfactant (Poloxamer 407) and compare them in terms of improving the dissolution of ferulic acid. Solid dispersions were obtained by methods of crushing, kneading, co-evaporation, fusion, spray drying and freeze drying at concentrations of 10 and 20%. The formulations showed a yield between 38.6 and 80.2%. All formulations showed adequate amounts of efficiency of incorporation, greater than 80%. The solid dispersions were characterized by scanning electron microscopy, X-ray diffraction and spectroscopy in the infrared region in Fourier transform, whose results confirmed the acquisition of solid dispersions. The dissolution characteristics of the pure drug and the formulations were compared. Solid dispersions exhibited greater efficiency in improving the speed of dissolution of the ferulic acid, explainable by the effect of Poloxamer 407 surfactant. A highest increase of dissolving was obtained with the formulation obtained by the method of freeze drying at a concentration of 10%, with dissolution efficiency of 93.83%. The dissolution profiles showed the best fit to a monoexponential equation. These results suggest that the solid dispersions prepared with the use of Poloxamer 407, containing the drug, are strategies feasible in the pharmaceutical industry.
O ácido ferúlico tem atividade antioxidante, anti-inflamatória, antitrombótica, anticancerígena, neuroprotetora, cardioprotetora e fotoprotetora. No entanto, apesar dessas atividades biológicas, sua utilidade terapêutica é limitada devido a certas propriedades físico-químicas desfavoráveis, notadamente a baixa solubilidade aquosa. É qualificado como fármaco da Classe II pelo Sistema de Classificação Biofarmacêutica e, portanto, sua dissolução é etapa limitante da absorção, podendo apresentar problemas de biodisponibilidade. Assim, considerando o elevado número de propriedades farmacológicas atribuídas ao ácido ferúlico, o objetivo desse trabalho foi desenvolver e caracterizar dispersões sólidas contendo ácido ferúlico, hidrofóbico, e um surfactante não-iônico Poloxamer 407 e compará-las quanto à melhoria na dissolução do ácido ferúlico. As dispersões sólidas foram obtidas pelos métodos de trituração, malaxagem, coevaporação, fusão, liofilização e spray-drying nas concentrações de 10 e 20%. As formulações apresentaram um rendimento entre 38,6 e 80,2%. Todas as formulações mostraram valores de eficiência de incorporação adequados, superiores a 80%. As dispersões sólidas foram caracterizadas por microscopia eletrônica de varredura, por difração de raios X e por espectroscopia na região do infravermelho com transformada em Fourier, cujos resultados comprovaram a obtenção das dispersões sólidas. As características de dissolução entre o fármaco puro e as formulações foram comparadas. As dispersões sólidas apresentaram maior eficiência em melhorar a velocidade de dissolução do ácido ferúlico, explicável pelo efeito tensoativo do Poloxamer 407. Maior incremento da dissolução foi obtido com a formulação obtida pelo método de liofilização na concentração de 10%, com eficiência de dissolução de 93,83%. Os perfis de dissolução apresentaram o melhor ajuste para a equação monoexponencial. Esses resultados sugerem que as dispersões sólidas elaboradas com o uso do Poloxamer 407, contendo o fármaco, são estratégias viáveis na indústria farmacêutica.

La gonococcie est une infection sexuellement transmissible due au gonocoque. Elle est devenue un problème majeur de santé publique du fait de la multirésistance aux antibiotiques, mais surtout de la résistance au traitement de dernière intention actuellement en vigueur. Lactobacillus crispatus, une bactérie naturelle, commensale du vagin de la femme, s’est montré efficace pour inhiber le gonocoque. Les gels, une forme galénique bien acceptée, sont déjà utilisés pour le traitement des infections genitales de la femme. Disposer d’un gel contenant Lactobacillus crispatus, efficace, facile à administrer par la femme elle-même parait donc attractif pour la prévention de la gonococcie. Ainsi, nous avons conçu un gel à base d’un polymère thermogélifiant, le poloxamer 407 et d’un polymère biocompatible, l’alginate de sodium. Dans un premier temps, une étude physico-chimique du mélange de polymères a permis de retenir les concentrations optimisées. Dans un second temps, la souche de Lactobacillus choisie a été caractérisée et introduite dans le mélange de polymères. Les propriétés physicochimiques dont les caractéristiques rhéologiques, l’expulsion d’un dispositif d’administration, la stabilité, la microstructure ainsi que l’efficacité in vitro du gel obtenu ont été étudiés. Une répartition homogène de Lactobacillus crispatus a été observée dans le gel. Ce système est facilement administrable et possède des propriétés rhéologiques favorables à son étalement et son maintien dans la lumière vaginale. Ce gel a permis d’inhiber la croissance du gonocoque in vitro
Gonorrhea is a sexually transmitted infection caused by Neisseria gonorrhoeae. It has become a major public health issue due to multidrug resistance, especially resistance to the current last-intention treatment.Lactobacillus crispatus, a natural bacterium, commensal to the woman's vagina, has been shown to inhibit Neisseria gonorrhoeae. Gels, a well-accepted dosage form, are already used for the treatment of woman's genital infections. Having a gel containing Lactobacillus crispatus, that is effective, easy to administer by the woman herself, would be ideal for the prevention of gonorrhea. Thus, we designed a gel based on a thermogelling polymer, poloxamer 407, and a biocompatible polymer, sodium alginate. First, a physicochemical study of the polymers mixtures allowed to select the optimized concentrations. Second, the selected Lactobacillus strain was characterized and introduced into the optimized polymer mixture. Physicochemical properties including rheological characteristics, expulsion from a device, stability, microstructure as well as in vitro gel efficacy were studied. A homogeneous distribution of Lactobacillus crispatus was observed in the gel. It was easily administered and its rheological properties were suitable for its spreading and its long reidence time in the vaginal lumen. This gel showed an inhibition of gonococcal growth in vitro

Le traitement des infections sur corps etranger demeure un probleme preoccupant, notamment en chirurgie orthopedique. La vancomycine et la gentamicine occupent chacune une place importante dans le traitement de ce type d'infection. Ce travail evalue la faisabilite et l'efficacite de l'administration locale de ces antibiotiques a l'interieur d'une matrice de poloxamer 407. Les proprietes rheologiques particulieres de ce vehicule permettent son administration sous forme liquide directement au site recherche, et sa gelification in situ a la temperature corporelle. L'association de l'antibiotique au poloxamer n'alterait ni l'activite anti-infectieuse de l'antibiotique, ni les proprietes physiques du gel. L'etude des proprietes diffusionnelles de cette association a montre une liberation prolongee de l'agent anti-infectieux tant in vitro qu'in vivo, chez l'animal sain et infecte. L'adherence bacterienne est une etape primordiale de la colonisation de la surface d'un corps etranger, elle est suivie de la formation d'un biofilm qui enveloppe et protege les germes des defenses de l'hote et de l'activite des antibiotiques. In vitro, nos resultats ont montre que le poloxamer 407 agit de deux manieres sur le developpement de s. Aureus et s. Epidermidis a la surface d'un corps etranger : en diminuant le nombre de bacteries adherentes, et en restaurant la sensibilite des bacteries adherentes residuelles a l'activite des antibiotiques. In vivo, sur un modele d'infection a s. Aureus sur cage tissulaire chez le cobaye, l'administration locale d'une association vancomycine / poloxamer 407 a permis d'inhiber l'adhesion des bacteries au corps etranger et de steriliser le site d'inoculation. Ces donnees suggerent que le poloxamer 407 est un vehicule adapte pour une antibiotherapie locale, particulierement au niveau de zones faiblement vascularisees et/ou lors de l'utilisation d'antibiotiques a faible index therapeutique.

CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior
As dislipidemias e a obesidade sÃo distÃrbios cuja prevalÃncia vem aumentando no Brasil e no mundo, e sÃo extremamente importantes do ponto de vista da saÃde pÃblica, pois ambas desempenham um importante papel no cenÃrio das doenÃas cardiovasculares. Por terem cunho inflamatÃrio, trazem danos oxidativos aos tecidos e ÃrgÃos, comprometendo seu funcionamento. O Ãleo de coco extra virgem (OCEV), extraÃdo do fruto do coqueiro (Cocos nucifera L.), o coco, à uma gordura saturada rica em Ãcidos graxos de cadeia mÃdia e compostos polifenÃlicos, os quais evidenciaram atividades antimicrobiana, antitrombÃtica e antioxidante. O objetivo do presente estudo à averiguar os efeitos do Ãleo de coco extra virgem sobre o perfil bioquÃmico lipÃdico e antioxidante no tratamento da obesidade e dislipidemia em camundongos, assim como no estresse oxidativo deles decorrentes. A dislipidemia foi induzida por injeÃÃo intraperitoneal de soluÃÃo de poloxamer P-407 em camundongos machos, que foram tratados com fenofibrato ou Ãleo de coco a 3, 6 ou 12mL/Kg (P+OC3, P+OC6 e P+OC12, respectivamente) 2 e 26 horas apÃs a induÃÃo, com coleta 24 e 48 horas pÃs-induÃÃo e dosagem de glicose, triacilglicerÃis e colesterol total. A obesidade foi induzida por raÃÃo hipercalÃrica durante 15 semanas, com tratamento simultÃneo com sibutramina ou Ãleo de coco extra virgem a 5%, 7,5% ou 10% (DH+OC5, DH+OC7,5 e DH+OC10, respectivamente) em peso incorporado à raÃÃo hipercalÃrica, com dosagens de glicose, triacilglicerÃis, colesterol total, HDL e nÃo-HDL, ALT e AST. Ao fim dos protocolos, o fÃgado foi removido para dosagem dos parÃmetros antioxidantes catalase e TBARS. No protocolo de dislipidemia os nÃveis de triacilglicerÃis foram reduzidos em todos os grupos tratados com OCEV (reduÃÃo entre 68,31% e 114,8% em relaÃÃo a P). Catalase (aumento de 203%) e TBARS (reduÃÃo de 70,90%) tiveram resultados benÃficos em P+OC12 em relaÃÃo a P. Na obesidade, a glicemia e colesterol total diminuÃram em DH+OC5 (31,77% e 32,28%, respectivamente). Os nÃveis de HDL aumentaram em todos os grupos que consumiram OCEV, assim como a atividade plasmÃtica de alanina aminotransferase (ALT) (31,60% e 38,89%, respectivamente); a concentraÃÃo plasmÃtica de triacilglicerÃis reduziu-se em DH+OC7,5 (48,55%) em relaÃÃo a DH, assim como a atividade de aspartato aminotransferase (AST) aumentou em DH+OC10 (44,52%). Catalase aumentou em DH+OC5 (145,61%), e TBARS reduziu em DH+OC10 (74,15%). Conclui-se que o OCEV possui efeitos benÃficos sobre parÃmetros bioquÃmicos do perfil lipÃdico e oxidativo de camundongos dislipidÃmicos e obesos.

RODRIGUES, Hector Galdino. Avaliação dos efeitos do óleo de coco (Cocos nucifera L.) extra virgem em protocolos de indução de obesidade por dieta hipercalórica e indução de dislipidemia por poloxamer P-407 em camundongos. 2015. 103 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Faculdade de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Fortaleza, 2015.
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Dyslipidemia and obesity are disorders whose prevalence is increasing in Brazil and worldwide, and are extremely important in Public Health , as both play important role on cardiovascular diseases development . Due to its inflammatory nature, occurs oxidative damage to tissues and organs, compromising its funcionality . Extra virgin coconut oil (OCEV), extracted from the fruit of the coconut pal m (Cocos nucifera L.), coconut, is a saturated fat rich in medium chain fatty acids and polyphenolic compounds, which showed antimicrobial, antithrombotic and antioxidant activity . The aim of this study is to investigate the effects of extra virgin coconut oil on lipid and antioxidant profile in the treatment of obesity and dyslipidemia in mice as well as in their oxidative stress arising. Dyslipidemia was induced by intraperitonea l injection of poloxamer solution P - 407 in male mice that were treated with fenofibrate or coconut oil to 3, 6 or 12 mL / kg ( P+OC3, P+OC6 e P+OC12 , respectively) 2 and 26 hours after induction, with collection 24 and 48 hours post - induction and dosage of glucose, triglycerides and total cholesterol. Obesity was induced by hypercaloric diet for 15 weeks with simultaneous treatment with sibutramine or extra virgin coconut oil 5%, 7.5% or 10% ( DH+OC5, DH+OC7,5 and DH+OC10 , respectively) by weight incorporated in hypercaloric diet, with determination of glucose, triglycerides, total cholesterol, non - HDL and HDL, ALT and AST. At the end of the protocols, the liver was removed for determination of antioxidant catalase and TBARS parameters. In dyslipidemia protoco l triglycerides levels were reduced in all groups treated with OCEV (reduction from 68.31% to 114.8% relative to P). Catalase (up 203%) and TBARS (down 70.90%) had beneficial results in P + OC12 relative to P. In obesity, blood glucose and total cholestero l decreased by DH + OC5 (31.77% and 32 28%, respectively). HDL levels increased in all groups who consumed OCEV, as well as the plasma activity of alanine aminotransferase (ALT) (31.60% and 38.89%, respectively); the serum triglycerides decreased by DH + O C7,5 (48.55%) compared to HD, as well as the aspartate aminotransferase activity (AST) increased by DH + OC10 (44.52%). Catalase increased by DH + OC5 (145.61%), and TBARS decreased by DH + OC10 (74.15%). It concludes that the OCEV has beneficial effects o n oxidative and lipid profile of dyslipidemic and obese mice
As dislipidemias e a obesidade são distúrbios cuja prevalência vem aumentando no Brasil e no mundo, e são extremamente importantes do ponto de vista da saúde pública, pois ambas desempenham um importante papel no cenário das doenças cardiovasculares. Por terem cunho inflamatório, trazem danos oxidativos aos tecidos e órgãos, comprometendo seu funcionamento. O óleo de coco extra virgem (OCEV), extraído do fruto do coqueiro (Cocos nucifera L.), o coco, é uma gordura saturada rica em ácidos graxos de cadeia média e compostos polifenólicos, os quais evidenciaram atividades antimicrobiana, antitrombótica e antioxidante. O objetivo do presente estudo é averiguar os efeitos do óleo de coco extra virgem sobre o perfil bioquímico lipídico e antioxidante no tratamento da obesidade e dislipidemia em camundongos, assim como no estresse oxidativo deles decorrentes. A dislipidemia foi induzida por injeção intraperitoneal de solução de poloxamer P-407 em camundongos machos, que foram tratados com fenofibrato ou óleo de coco a 3, 6 ou 12mL/Kg (P+OC3, P+OC6 e P+OC12, respectivamente) 2 e 26 horas após a indução, com coleta 24 e 48 horas pós-indução e dosagem de glicose, triacilgliceróis e colesterol total. A obesidade foi induzida por ração hipercalórica durante 15 semanas, com tratamento simultâneo com sibutramina ou óleo de coco extra virgem a 5%, 7,5% ou 10% (DH+OC5, DH+OC7,5 e DH+OC10, respectivamente) em peso incorporado à ração hipercalórica, com dosagens de glicose, triacilgliceróis, colesterol total, HDL e não-HDL, ALT e AST. Ao fim dos protocolos, o fígado foi removido para dosagem dos parâmetros antioxidantes catalase e TBARS. No protocolo de dislipidemia os níveis de triacilgliceróis foram reduzidos em todos os grupos tratados com OCEV (redução entre 68,31% e 114,8% em relação a P). Catalase (aumento de 203%) e TBARS (redução de 70,90%) tiveram resultados benéficos em P+OC12 em relação a P. Na obesidade, a glicemia e colesterol total diminuíram em DH+OC5 (31,77% e 32,28%, respectivamente). Os níveis de HDL aumentaram em todos os grupos que consumiram OCEV, assim como a atividade plasmática de alanina aminotransferase (ALT) (31,60% e 38,89%, respectivamente); a concentração plasmática de triacilgliceróis reduziu-se em DH+OC7,5 (48,55%) em relação a DH, assim como a atividade de aspartato aminotransferase (AST) aumentou em DH+OC10 (44,52%). Catalase aumentou em DH+OC5 (145,61%), e TBARS reduziu em DH+OC10 (74,15%). Conclui-se que o OCEV possui efeitos benéficos sobre parâmetros bioquímicos do perfil lipídico e oxidativo de camundongos dislipidêmicos e obesos.