Literatura académica sobre el tema "Planar Cellular Polarity (PCP)"
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Artículos de revistas sobre el tema "Planar Cellular Polarity (PCP)"
Devenport, Danelle. "The cell biology of planar cell polarity". Journal of Cell Biology 207, n.º 2 (27 de octubre de 2014): 171–79. http://dx.doi.org/10.1083/jcb.201408039.
Texto completoAxelrod, Jeffrey D. y Helen McNeill. "Coupling Planar Cell Polarity Signaling to Morphogenesis". Scientific World JOURNAL 2 (2002): 434–54. http://dx.doi.org/10.1100/tsw.2002.105.
Texto completoMlodzik, Marek. "Planar cell polarity: moving from single cells to tissue-scale biology". Development 147, n.º 24 (15 de diciembre de 2020): dev186346. http://dx.doi.org/10.1242/dev.186346.
Texto completoTower-Gilchrist, Cristy, Stephanie A. Zlatic, Dehong Yu, Qing Chang, Hao Wu, Xi Lin, Victor Faundez y Ping Chen. "Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear". Molecular Biology of the Cell 30, n.º 18 (15 de agosto de 2019): 2422–34. http://dx.doi.org/10.1091/mbc.e16-08-0592.
Texto completoPadmanabhan, Krishnanand, Hanna Grobe, Jonathan Cohen, Arad Soffer, Adnan Mahly, Orit Adir, Ronen Zaidel-Bar y Chen Luxenburg. "Thymosin β4 is essential for adherens junction stability and epidermal planar cell polarity". Development 147, n.º 23 (1 de diciembre de 2020): dev193425. http://dx.doi.org/10.1242/dev.193425.
Texto completoKim, Su Kyoung, Asako Shindo, Tae Joo Park, Edwin C. Oh, Srimoyee Ghosh, Ryan S. Gray, Richard A. Lewis et al. "Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis". Science 329, n.º 5997 (29 de julio de 2010): 1337–40. http://dx.doi.org/10.1126/science.1191184.
Texto completoBabayeva, Sima, Yulia Zilber y Elena Torban. "Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes". American Journal of Physiology-Renal Physiology 300, n.º 2 (febrero de 2011): F549—F560. http://dx.doi.org/10.1152/ajprenal.00566.2009.
Texto completoZilber, Yulia, Sima Babayeva, Jung Hwa Seo, Jia Jia Liu, Steven Mootin y Elena Torban. "The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium". Molecular Biology of the Cell 24, n.º 5 (marzo de 2013): 555–65. http://dx.doi.org/10.1091/mbc.e12-06-0437.
Texto completoGault, William J., Patricio Olguin, Ursula Weber y Marek Mlodzik. "Drosophila CK1-γ, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking". Journal of Cell Biology 196, n.º 5 (5 de marzo de 2012): 605–21. http://dx.doi.org/10.1083/jcb.201107137.
Texto completoGajos-Michniewicz, Anna y Malgorzata Czyz. "WNT Signaling in Melanoma". International Journal of Molecular Sciences 21, n.º 14 (9 de julio de 2020): 4852. http://dx.doi.org/10.3390/ijms21144852.
Texto completoTesis sobre el tema "Planar Cellular Polarity (PCP)"
Barrott, Jared James. "Wnt5a Signaling Independently of the Planar Cell Polarity Pathway Resulting in Convergent Extension and Neural Tube Closure During Vertebrate Development". Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2612.pdf.
Texto completoBoëx, Myriam. "Implication d’une nouvelle voie de signalisation médiée par le complexe MuSK/Vangl2 dans la connectivité neuromusculaire". Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS258.pdf.
Texto completoThe neuromuscular junction (JNM) is a peripheral synapse formed by the anatomic and functional contact between a motor neuron and a striated skeletal muscle fiber. NMJ development requires a dynamic communication between motor axons and their muscle targets through several reciprocal signaling. Among the limited number of secreted factors that orchestrate this trans-synaptic coordination, the Wnts diffusible cues have emerged as critical signals for synaptic differentiation, yet how Wnt signaling drives NMJ formation and maintenance remain poorly understood and controversial in mammals. In this context, the aims of my PhD project were 1) to validate the functional role of Wnt-MuSK interaction in vivo and 2) to study the Wnt Planar Cell Polarity (PCP) pathway during NMJ assembly and maintenance in mammals. Interestingly, our team showed that Van Gogh-like protein 2 (Vangl2), a core PCP component, is accumulated at developing NMJ, at both pre- and postsynaptic sites. Moreover, Vangl2 interacts with a subset of Wnt morphogens that are secreted at the NMJ suggesting that a Wnt/Vangl2-PCP signaling is involved in NMJ development. By using a set of mutant mice along with a large panel of cell biological and biochemical assays, I found that muscle Vangl2 is critical for NMJ assembly and maintenance, by controlling the level of MuSK signaling activity. Collectively, my results uncover a new Wnt/PCP signaling in the muscle, relying on Vangl2/MuSK interaction that shapes neuromuscular connectivity by regulating postsynaptic assembly and integrity
Watson, Julia Alice. "Investigating the role of Wnt/Planar cell polarity (PCP) in Neuromesodermal Progenitors (NMPs)". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31193.
Texto completoGiese, Arnaud. "Régulation de la protéine centrale de la polarité planaire cellulaire Vangl2 dans l’organe de Corti". Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21761/document.
Texto completoSeveral epithelia exhibit a second polarity perpendicular to the apico-basal axis, called planar polarity and that governs the orientation of structures such as stereocilia and hear. Our laboratory studies planar polarity, using mammalian cochlear sensory epithelium and we focus our studies on Vangl2, that we identified as the first mammalian planar polarity gene. Vangl2 encodes a four-transmembrane protein that contains a PDZ binding domain in its C-terminus tail. Vangl2 is asymmetrically located at the junction between mechanosensory hair cells and supporting cells, and this asymmetry appears important for planar cell polarity. I have shown in my thesis, using STED microscopy, that Vangl2 asymmetry is mainly due to an accumulation of Vangl2 to the distal side of supporting cells. I sought to dissect the molecular role of Vangl2 by analysing its trafficking within the cochlear epithelium. Deletion analysis shows that the last 12 amino acids, unlike its N-terminus tail are essential for Vangl2 endoplasmic reticulum sorting, its plasma membrane targeting and its function. Conditional mutant mice analysis show that Scrib1, which we have previously shown, interacts with Vangl2 through the PDZ binding domain of its C-terminal tail, is not the protein mediating this asymmetry. My work also highlight that GIPC1 had a role in the regulation of PCP and maintaining the integrity of hair bundles of sensory cells, and that the complex GIPC1/Myosin VI could regulate Vangl2 asymmetry in the organ of Corti
Martinez, Sébastien. "Rôle de la protéine tyrosine kinase 7 dans le cancer colorectal et la polarité planaire cellulaire". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4019.
Texto completoThe non-canonical WNT/planar cell polarity (WNT/PCP) pathway plays important roles in morphogenetic processes in vertebrates. Among WNT/PCP components, protein tyrosine kinase 7 (PTK7) is a tyrosine kinase receptor with poorly defined functions lacking catalytic activity. We show that PTK7 associates with receptor tyrosine kinase-like orphan receptor 2 (ROR2) to form a heterodimeric complex in mammalian cells and physically and functionally interact with the non-canonical WNT5A ligand, leading to JNK activation and cell movements. In the Xenopus embryo, Ptk7 functionally interacts with Ror2 to regulate protocadherin papc expression and morphogenesis. Furthermore, we show that Ptk7 is required for papc activation induced by Wnt5a and that Wnt5a stimulates the release of the Ptk7 intracellular domain, which can translocate into the nucleus and activate papc expression. Moreover, using a Tissue MicroArray produced from CRC patients we correlated PTK7 expression with pathological features and patient outcome. PTK7 was significantly up-regulated in CRC tissue, and its overexpression was found in 34% of patients. In CRC cell lines, shRNA PTK7 reduced migration, but did not affect cell proliferation and resistance to drugs. In a xenograft mouse model, downregulation of PTK7 led to reduced tumor growth, whereas its overexpression in PTK7-negative cancer cells led to increased metastatic events. This work reveals novel molecular mechanisms of action of PTK7 in non-canonical WNT/PCP signaling that may promote cell and tissue movements and define PTK7 expression as a potential prognostic biomarker and a novel therapeutic target in CRC
Godfrey, Grayland W. II. "Characterizing the Role of Key Planar Cell Polarity Pathway Components in Axon Guidance". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4841.
Texto completoTanner, Raymond. "A Role for the Planar Cell Polarity Pathway in Neuronal Positioning Along the AP Axis of C. elegans". Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31521.
Texto completoSchäfer, Simon Thomas [Verfasser]. "ATP6AP2 is critically involved in adult hippocampal neurogenesis and reveals stage-specific functions for Wnt/ß-Catenin and Wnt/Planar Cell Polarity (PCP) signaling / Simon Thomas Schäfer". Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1069389331/34.
Texto completoAllen, John C. "FGF4 Induced Wnt5a Gradient in the Limb Bud Mediates Mesenchymal Cell Directed Migration and Division". BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4309.
Texto completoEl-Hassan, Abdul-Rahman. "Caractérisation moléculaire et fonctionnelle d'un nouvel allèle du gène de la polarité cellulaire planaire (PCP) Vangl2". Thèse, 2017. http://hdl.handle.net/1866/20536.
Texto completoLibros sobre el tema "Planar Cellular Polarity (PCP)"
Zaffran, Stéphane. Cardiac growth II: Cardiomyocyte polarization. Editado por José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso y Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0010.
Texto completoKühn, Wolfgang y Gerd Walz. The molecular basis of ciliopathies and cyst formation. Editado por Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0303.
Texto completoCapítulos de libros sobre el tema "Planar Cellular Polarity (PCP)"
Moreira, Sofia, Jaime A. Espina, Joana E. Saraiva y Elias H. Barriga. "A Toolbox to Study Tissue Mechanics In Vivo and Ex Vivo". En Methods in Molecular Biology, 495–515. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2035-9_29.
Texto completo"Planar Cell Polarity (PCP)". En Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1502. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_12937.
Texto completoGao, Bo. "Wnt Regulation of Planar Cell Polarity (PCP)". En Planar Cell Polarity During Development, 263–95. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394592-1.00008-9.
Texto completoBoutin, Camille, André M. Goffinet y Fadel Tissir. "Celsr1–3 Cadherins in PCP and Brain Development". En Planar Cell Polarity During Development, 161–83. Elsevier, 2012. http://dx.doi.org/10.1016/b978-0-12-394592-1.00010-7.
Texto completoActas de conferencias sobre el tema "Planar Cellular Polarity (PCP)"
Asad, Mohammad, Meng Kang Wong, Tuan Zea Tan, David Virshup, Jean Paul Thiery y Ruby Yun-Ju Huang. "Abstract A30: Frizzled-7 (FZD7)-mediated non-canonical Wnt-Planar Cell Polarity (PCP) signalling pathway as a novel molecular driver for the C5/Proliferative/Stem-A molecular subtype of ovarian cancer." En Abstracts: AACR Special Conference: Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; October 17-20, 2015; Orlando, FL. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3265.ovca15-a30.
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