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1

Hiemstra, Pieter S. y Sebastian A. J. Zaat, eds. Antimicrobial Peptides and Innate Immunity. Basel: Springer Basel, 2013. http://dx.doi.org/10.1007/978-3-0348-0541-4.

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2

-D, Hesch R. y Atkinson M. J, eds. Peptide hormones as mediators in immunology and oncology. New York: Raven Press, 1985.

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3

Ezekowitz, R. Alan B. y Jules A. Hoffmann. Innate Immunity. New Jersey: Humana Press, 2002. http://dx.doi.org/10.1385/1592593208.

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4

Ewbank, Jonathan y Eric Vivier, eds. Innate Immunity. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-570-1.

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5

Jonathan, Ewbank y Vivier E, eds. Innate immunity. Totowa, N.J: Humana Press, 2008.

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6

B, Ezekowitz R. Alan y Hoffmann J. 1941-, eds. Innate immunity. Totowa, NJ: Humana Press, 2003.

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7

Ezekowitz, R. Alan B. y Jules A. Hoffmann, eds. Innate Immunity. Totowa, NJ: Humana Press, 2003. https://doi.org/10.1007/978-1-59259-320-0.

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8

Gassmann, Walter, ed. Plant Innate Immunity. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9458-8.

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9

Mossman, Karen, ed. Innate Antiviral Immunity. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7237-1.

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10

Loon, L. C. van. Plant innate immunity. Editado por Wiley online library. Amsterdam: Elsevier Academic Press, 2009.

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11

Zheng, Chunfu, ed. Antiviral Innate Immunity. New York, NY: Springer US, 2025. http://dx.doi.org/10.1007/978-1-0716-4108-8.

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12

Ezekowitz, R. Alan B. Collectins and innate immunity. New York: Springer, 1996.

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13

Arne, Egesten, Schmidt Axel 1962- y Herwald Heiko, eds. Trends in innate immunity. Basel: Karger, 2008.

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14

Mathis, Durand y Morel Clara V, eds. New research on innate immunity. New York: Nova Science, 2008.

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15

Allen, Irving C., ed. Mouse Models of Innate Immunity. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-481-4.

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16

Lambris, John D., ed. Current Topics in Innate Immunity. New York, NY: Springer New York, 2007. http://dx.doi.org/10.1007/978-0-387-71767-8.

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17

Cui, Jun, ed. Autophagy Regulation of Innate Immunity. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0606-2.

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18

Chadwick, Derek J. y Jamie Goode, eds. Innate Immunity to Pulmonary Infection. Chichester, UK: John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/9780470035399.

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19

Allen, Irving C., ed. Mouse Models of Innate Immunity. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9167-9.

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20

Alper, Scott y William J. Janssen, eds. Lung Innate Immunity and Inflammation. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8570-8.

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21

Symposium on Innate Immunity to Pulmonary Infection (2005 University of Cape Town, Medical School). Innate Immunity to Pulmonary Infection. New York: John Wiley & Sons, Ltd., 2007.

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22

D, Lambris J. y International Conference on Innate Immunity (4th : Corfu, Greece : 2006), eds. Current topics in innate immunity. Berlin: Springer, 2007.

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23

J, Ishii Ken y Akira S, eds. Nucleic acids in innate immunity. Boca Raton: CRC Press, 2008.

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24

Derek, Chadwick, Goode Jamie y Novartis Foundation, eds. Innate immunity to pulmonary infection. Chichester: John Wiley, 2006.

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25

Kishore, Uday, ed. Target Pattern Recognition in Innate Immunity. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0901-5.

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26

Vidhyasekaran, P. PAMP Signals in Plant Innate Immunity. Dordrecht: Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-007-7426-1.

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27

Lambris, John D. y George Hajishengallis, eds. Current Topics in Innate Immunity II. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-0106-3.

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28

Katsikis, Peter D., Stephen P. Schoenberger y Bali Pulendran, eds. Crossroads between Innate and Adaptive Immunity. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-34814-8.

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29

Pulendran, Bali y Rafi Ahmed, eds. From Innate Immunity to Immunological Memory. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/3-540-32636-7.

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30

D, Katsikis Peter, Pulendran B y Schoenberger Stephen P, eds. Crossroads between innate and adaptive immunity. New York: Springer, 2007.

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31

Antimicrobial Peptides And Innate Immunity. Springer, 2013.

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32

Hiemstra, Pieter S. y Sebastian A. J. Zaat. Antimicrobial Peptides and Innate Immunity. Springer, 2015.

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33

Hiemstra, Pieter S. y Sebastian A. J. Zaat. Antimicrobial Peptides and Innate Immunity. Springer, 2013.

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34

Hiemstra, Pieter S. y Sebastian A. J. Zaat. Antimicrobial Peptides and Innate Immunity. Springer London, Limited, 2013.

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35

Zaat, Sebastian A. Antimicrobial Peptides and Innate Immunity. Birkhäuser Boston, 2013.

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36

Robinson, Mark W. y Andrew T. Hutchinson, eds. Antimicrobial peptides: utility players in innate immunity. Frontiers Media SA, 2012. http://dx.doi.org/10.3389/978-2-88919-077-5.

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37

Voll, Reinhard E. y Barbara M. Bröker. Innate vs acquired immunity. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0048.

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The innate and the adaptive immune system efficiently cooperate to protect us from infections. The ancient innate immune system, dating back to the first multicellular organisms, utilizes phagocytic cells, soluble antimicrobial peptides, and the complement system for an immediate line of defence against pathogens. Using a limited number of germline-encoded pattern recognition receptors including the Toll-like, RIG-1-like, and NOD-like receptors, the innate immune system recognizes so-called pathogen-associated molecular patterns (PAMPs). PAMPs are specific for groups of related microorganisms and represent highly conserved, mostly non-protein molecules essential for the pathogens' life cycles. Hence, escape mutants strongly reduce the pathogen's fitness. An important task of the innate immune system is to distinguish between harmless antigens and potentially dangerous pathogens. Ideally, innate immune cells should activate the adaptive immune cells only in the case of invading pathogens. The evolutionarily rather new adaptive immune system, which can be found in jawed fish and higher vertebrates, needs several days to mount an efficient response upon its first encounter with a certain pathogen. As soon as antigen-specific lymphocyte clones have been expanded, they powerfully fight the pathogen. Importantly, memory lymphocytes can often protect us from reinfections. During the development of T and B lymphocytes, many millions of different receptors are generated by somatic recombination and hypermutation of gene segments making up the antigen receptors. This process carries the inherent risk of autoimmunity, causing most inflammatory rheumatic diseases. In contrast, inadequate activation of the innate immune system, especially activation of the inflammasomes, may cause autoinflammatory syndromes.
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38

Noordenbos, Troy y Dominique Baeten. Immune mechanisms: innate immunity. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0007.

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Innate immune mechanisms are strongly implied in the pathophysiology of spondyloarthritis (SpA). This chapter discusses available data on the role of the innate immune system in relation to HLA-B27, genetic associations, and the cellular and molecular characteristics of disease target tissue. Regarding the linkage with MCH-class I molecule HLA-B27, the chapter discusses the arthritogenic peptide hypothesis and three popular antigen-independent theories. The genetic architecture of the disease argues against a role for the adaptive immune system and identifies cytokine pathways, such as IL-1, TNF, and IL-23/IL-17. In experimental as well as in human SpA, the importance of these cytokine pathways are confirmed by effective reduction of signs and symptoms upon blockade of specific molecules. In-depth cellular and molecular analysis of the target tissue identifies a contribution of cells with strong innate features, rather than cells of the adaptive immune system.
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39

Zasloff, Michael. Antimicrobial Peptides: Their Mechanisms and Role in Innate Immunity, Drug Discovery, and Development. Wiley & Sons, Incorporated, John, 2018.

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40

Antimicrobial peptides: Methods and protocols. New York: Humana Press/Springer, 2010.

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41

Giuliani, Andrea y Andrea C. Rinaldi. Antimicrobial Peptides: Methods and Protocols. Humana Press, 2016.

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42

(Editor), Masaru Taniguchi, Shizuo Akira (Editor) y Toshimori Nakayama (Editor), eds. The Innate Immune System: Strategies for Disease Control: Proceedings of the Uehara Memorial Foundation Symposium on the Innate Immune System: Strategies ... July 2005, ICS 1285 (International Congress). Elsevier, 2006.

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43

Innate Immunity. Elsevier, 2019. http://dx.doi.org/10.1016/c2019-0-03243-8.

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44

Ezekowitz, R. Alan B. y Jules A. Hoffmann. Innate Immunity. Island Press, 2002.

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45

Ewbank, Jonathan y Eric Vivier. Innate Immunity. Humana Press, 2010.

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46

Innate immunity. Copenhagen: Munksgaard, 2000.

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47

Hoffmann, Jules A. y R. Alan B. Ezekowitz. Innate Immunity. Humana, 2012.

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48

Loon, L. C. van. Plant Innate Immunity. Elsevier Science & Technology Books, 2009.

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49

Plant Innate Immunity. Elsevier Science & Technology Books, 2009.

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50

Harrison, Mark. Natural and innate immunity. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198765875.003.0008.

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This chapter describes the microbiology of natural and innate immunity as it applies to Emergency Medicine, and in particular the Primary FRCEM examination. The chapter outlines the key details of barriers to infection, normal bacterial flora, and phagocytes and complement. This chapter is laid out exactly following the RCEM syllabus, to allow easy reference and consolidation of learning.
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