Literatura académica sobre el tema "Pedro y Antonio Lanusse, s.a"

Con el comienzo de la primavera de 1813, el sector más rancio del pueblo mallorquín —y el que no lo era tanto también— se vio convulsionado por la aparición de una traducción de El pacto social de Rousseau. En una remesa de 500 volúmenes, el envío remitido a Mallorca resultó poseer características particulares respecto de la edición matriz de 1500 ejemplares que había alumbrado las prensas valencianas de José Ferrer de Orga en 1812; entra ellas la de haber permutado el título por el subtítulo de la versión original: Principios del derecho político, y la de figurar estampadas en su portada las letras «A. G-M. y S.» como indicación del traductor, sobre las cuales se han venido barajando a lo largo del tiempo distintas teorías, y para las que ahora sugerimos nosotros un candidato.PALABRAS CLAVEPrincipios del derecho político, El contrato social, Antonio García Malo y Sánchez, Pedro Estala, Ignacio García Malo, Rousseau. With the beginning of the spring of 1813, the most reactionayr sector of Majorcan people –and that wich wasn’t so much too- was thrown into upheaval by the publication of translation of El pacto social by Rousseau. In an edition of 500 books the consignment which was delivered to Majorca turned out to have special characteristics with respect to the former edition of 1500 copies which José Ferrer de Orga’s Valencian presses had published in 1812. One of these features was that the title had been exchanged with the subtitle of the original edition: Principios del derecho politico, and that letters «A. G-M. y S.» were printed on its cover as a signal of the translator. These are initials about which several theories have been considered over time and, and for which we now suggest a candidate.KEY WORDSPrincipios del derecho político, El contrato social, Antonio García Malo y Sánchez, Pedro Estala, Ignacio García Malo, Rousseau.

Gerra zibila eta ondorengo gerraostea suspertzen hasiberritako euskal kultura eta antzertiarentzat kolpe latza izan ziren. “aitzol” eta “Lauaxeta” mugimendu euskaltzalearen bi pertsonaia funtsezko eta gailenen fusilamendua, eta Nazionalista sutsu eta nabarmendu gehienen erbesteratze eta kartzelaratzea, euskara erabiltzeko debekua, ... horrek guztiak haustura larria ekarri zuen. Alabaina, 1937an jaio eta urte berean, Bilbo erortzearekin bat zenduko zen Eguna lehen euskal egunkariaren garaiko kronikak jarraituz gero, faxistek okupatu gabeko eremuan hainbat antzezpenen berri topa dezakegu, hala nola Bilbon, otsailaren 11n, Bilboko Euzko Gastedija taldeak eskaini zuena. Emanaldi horretan Pearse-ren Iru Gudari, gazteleraz eta Soroaren Ezer ez ta festa euskaraz jokatu ziren. Hitzaldi honetan aztertzen dira zein dramaturgiatan kokatzen diren bai aipatu obra hauek, baita batipat Yeats-Sota-Altunaren, Negarrez igaro zan atsua; S. Arana/M. Sota-ren Libe; eta A.. Campión-A. Etxaberen Pedro Mari. Hala nola bereziki gerra gaitzat harturik honoko antzergigileok moldatu eta antzeztarazitako lanak: Antonio Ruíz de Azua “Ogoñope”, Euzkadi ́ko erri baten (Ekin, Mexico, 1950); Antonio Labaien, Lurrikara (Euzko Gogoa, Miarritze, 1955); Jean-Louis Davant, Agirre presidenta (Arrokiaga, 1995), eta Carlos Panera, Lauaxeta, herri antzerkia (Bilbao, 2005).

Otkriće Novoga svijeta postalo je izazov i za dominikanski red. Dominikanci su odigrali značajnu ulogu u evangelizaciji Amerike, ali i začetku onoga što će se u XX. stoljeću razviti u govor o ljudskim pravima. Važnu ulogu u tome imali su dominikanski teolozi Francisco de Vitoria i Domingo de Soto. Oni su, nadahnjujući se naukom Tome Akvinskoga, u rasprave o konkretnim problemima domorodačkih naroda u Novom svijetu unijeli pojmove naravnoga zakona i naravnoga prava. Naime dominikanci su u neposrednom kontaktu sa žrtvama nepoštovanja ljudskih prava u Novom svijetu, kao što su Pedro de Córdoba, Antonio Montesinos, Bartolomé de Las Casas, bili snažno povezani s dominikanskim teolozima na Sveučilištu u Salamanci u Španjolskoj koji su svoja mišljenja temeljili na nauku Tome Akvinskoga. Upravo je ta sinergija dominikanskoga intelektualnoga i apostolskoga života, najbolje izražena Akvinčevim »contemplata aliis tradere«, omogućila značajne pomake u obrani prava i ljudskoga dostojanstva domorodaca.

En el escrito dedicado a Los libros de Pedro Antonio de Aragón en la Biblioteca del Palacio de Peralada, publicado recientemente, se daba a conocer el origen de la biblioteca peraladense gracias a la labor de los hermanos Rocabertí. El objetivo del presente artículo es analizar un conjunto de cuarenta y un ejemplares con un denominador común: haber sido impresos por el prestigioso linaje italiano cuyo apellido aparece de distintas formas ‒Giunta, Giuntae, Giuncta, Giunti, Iuntae o Junta‒, según operaran en Italia, en Francia o bien en España. Aproximadamente, el cuarenta y nueve por ciento de estos ejemplares procede de la biblioteca condal, el resto llega a Peralada gracias a las adquisiciones de D. Miguel Mateu Pla (1898-1972). Con la intención de facilitar al investigador la continuación de la historia, dedicaremos la parte introductoria a la trayectoria cultural y bibliófila de D. Miguel, para proceder a continuación a detallar los ejemplares conservados en Peralada impresos en los tres países en los que operaron y las correspondientes ciudades –en las Repúblicas de Venecia y Florencia; en el Reino de Francia (Lyon-Lugduni) y en la Corona de Castilla (Burgos, Salamanca y Madrid)–, y analizar sus características especiales y únicas como las encuadernaciones, las procedencias debidas a la Desamortización, antiguos propietarios y distintos tipos de exlibris.

O objetivo deste trabalho é analisar dois livros do escritor gaúcho Luiz Antonio de Assis Brasil cujo objetivo principal é discutir a representação da realidade em diferentes linguagens. “O Pintor de Retratos” (2001) trata do debate entre fotografia e pintura como instrumentos de captação “objetiva” da realidade, a partir de um enredo que se passa no final do século XIX. Em “A Margem Imóvel do Rio” (2004) o problema da representação da realidade volta-se para a Literatura e a História. Também ambientado no final do século XIX, narra a história do cronista oficial da corte de D. Pedro II, que viaja ao Rio Grande do Sul em busca de Francisco da Silva, a quem o imperador teria prometido um título nobiliárquico. Além das temáticas de cada livro, a idéia deste estudo é discutir também as próprias obras literárias do autor como produtoras de sentido(s) para a construção de uma determinada visão sobre a representação das realidades abordadas.

Manuel José Pedraza Gracia = Giuseppe Seche, Libro e società in Sardegna tra Medioevo e prima Età Moderna, Firenze, Leo S. Olschki, 2018, 318 p. 978-88-222-6558-6. Camino Sánchez Oliveira = Giovanni Fiesoli, Friuli Venezia Giulia, Trentino-Alto Adige, Firenze, Sismel, 2017, 166 p. (RICABIM: Repertorio di inventari e cataloghi di bibliotheche medievali; 4.1) (Biblioteche e archvi; 31). 978-88-8450-796-9. Julio Macián Ferrandis = Francisco Gimeno Blay, et al. (eds.), Iacobi Primi instrumenta in Archivo Sedis Valentinae asservata, Valencia, Universitat de Valencia, 2017, 316 p. ISBN 978- 84-9134-078-2. Javier de Diego Romero = Carmen Morte García (coord.), Cantorales de la Orden de San Jerónimo en la catedral de Huesca: estudio interdisciplinar, Huesca, Instituto de Estudios Altoaragoneses, 2017, 435 p. ISBN 978-84-812-7284-0. Camino Sánchez Oliveira = Eduardo Peñalver Gómez (coord.), Fondos y procedencias: bibliotecas en la Biblioteca de la Universidad de Sevilla: exposición virtual 2013. Sevilla, Servicio de Publicaciones de la Universidad de Sevilla, 2013, 683 p. ISBN 978-84-472-1501-0. Alberto Gamarra Gonzalo = Fermín de los Reyes Gómez, La imprenta y el más allá: las bulas de San Esteban de Cuéllar (Segovia), Segovia, Fundación Las Edades del Hombre, Diputación de Segovia, Ayuntamiento de Cuéllar, Ayuntamiento de Aguilafuente, 2017, 286 p. ISBN 978-84-697-3860-3. Alberto Gamarra Gonzalo = Lluís Agustí, Mònica Baró, Pedro Rueda Ramírez (eds.), Edición y propaganda del libro. Las estrategias publicitarias en España e Hispanoamérica (siglos XVII-XX), Valencia, Calambur, 2018, 339 p. ISBN 978 84 8359 435 3. Manuel José Pedraza Gracia = Antonio Castillo Gómez (ed.), Culturas del escrito en el mundo occidental del Renacimiento a la Contemporaneidad, Madrid, Casa de Velázquez, 2015, 330 p. ISBN 978-84-15636-93-9. Camino Sánchez Oliveira = Antonio Castillo Gómez, El placer de los libros inútiles y otras lecturas en los Siglos de Oro, Madrid, Consejo Superior de Investigaciones Científicas, 2018, 113 p. ISBN 978-84-0010327-9. Alberto Gamarra Gonzalo = Javier Esteban Ochoa de Eribe, Discursos civilizadores: Escritores, lectores y lecturas de textos en euskera (c. 1767–c. 1833), Madrid, Sílex, 2018. 630 p. ISBN 978-84-7737-547-0. Manuel José Pedraza Gracia = Barbieri, Edoardo (ed.), Da Lucca a New York a Lugano: Giuseppe Martini libraio tra Otto e Novecento: atti del Convegno di Lucca, 17-18 ottobre 2014, Firenze, Leo S. Olschki, 2017, 252 p. ISBN 978-88-222-6541-8.

Abstract Background: The HER2DX assay is a genomic test in early-stage HER2-positive (HER2+) breast cancer that provides prognostic and predictive information. HER2DX is a supervised learning algorithm incorporating tumor size, nodal staging, and 4 gene expression signature scores (immune/IGG, tumor cell proliferation, luminal differentiation and the expression of the HER2 amplicon). Among them, the IGG signature is associated with both overall survival and probability of achieving a pathologic complete response (pCR). Here, we studied the association of percentage (%) of tumor infiltrating lymphocytes (TILs) with HER2DX scores, immune genes and other breast cancer-related genes. Methods: HER2DX and %TILs were evaluated in 670 formalin-fixed paraffin-embedded (FFPE) samples of HER2+ breast cancer, including in 3 clinical studies SHORTHER (n=437), PAMELA (n=86), a cohort of patients treated with anti-HER2 therapy plus chemotherapy at Hospital Clínic of Barcelona (n=147). The %TILs were quantified by histological evaluation with hematoxylin eosin staining according to International TILs Working Group guidelines. The nCounter platform determined the expression of 192 genes and HER2DX scores. Pearson correlations (Cor) and Significance Analysis of Microarrays (SAM) with a false-discovery rate (FDR) < 5% assessed the association between %TILs and the expression of individual genes or HER2DX signature scores. Results: A moderate correlation was observed between %TILs and the immune IGG signature (Cor=0.56, p< 0.001). Of note, 171 (25.52%) cases had low %TILs (< 30%) and high IGG score, while 1 (0.15%) case had high %TILs (≥30%) and low IGG score. The %TILs were significantly associated with the expression of immune genes, ERBB2, IGG signature and HER2 amplicon score, and negatively associated with the expression of luminal genes (i.e., ESR1, PRG and BCL2). An unclear relationship between TILs and proliferation genes was observed. Finally, moderate correlations were observed between %TILs and HER2DX pCR score (Cor=0.48, p< 0.001) and between %TILs and HER2DX risk score (Cor=0.33, p< 0.001). Conclusions: Important differences exist between the %TILs and the HER2DX IGG signature in early-stage HER2+ breast cancer. The %TILs should not be used to predict the HER2DX scores. Biologically, a higher %TILs indirectly capture a higher ERBB2 expression and a lower expression of luminal genes, both associated with response to anti-HER2 treatment. Citation Format: Esther Sanfeliu, Fara Brasó-Maristany, Maria Vittoria Dieci, Mercedes Marín-Aguilera, Blanca González-Farré, Gaia Griguolo, Tomas Pascual, Patricia Galván, Laura Angelats, Oleguer Castillo, Paula Blasco, Valeria Sirenko, Pedro Jares, Joan Antón Puig-Butillé, Laia Paré, Antonio Martínez, Antonio Llombart-Cussac, Javier Cortés, Ana Vivancos, Patricia Villagrasa, Joel S Parker, Charles M Perou, Aleix Prat, PierFranco Conte, Valentina Guarneri. Association between tumor infiltrating lymphocytes (TILs) and the HER2DX assay in early-stage of HER2-positive (HER2+) breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P4-02-30.

Abstract Introduction: CDK4/6 inhibitors (CDK4/6i), such as abemaciclib, ribociclib, and palbociclib, have significantly improved outcomes for patients with ER+/HER2− breast cancer. Nevertheless, they differ among each other in terms of chemical, biological, and pharmacological features, as well as toxicity profiles. Ribociclib causes concentration-dependent increases in the QTc interval, particularly in combination with tamoxifen. However, the pathogenesis of ribociclib-induced QTc prolongation remains unclear. We aim to determine whether QTc prolongation is caused by CDK4/6i in general or if it is associated with ribociclib only. Methods: We performed a systematic review and meta-analysis of randomized clinical trials (RCTs) to compare QTc prolongation in patients using CDK4/6i in combination with hormonal agents to patients that did not use CDK4/6i, including neoadjuvant, adjuvant, or metastatic scenarios in breast cancer. We searched Embase, PubMed and Cochrane Library databases from inception to June 2023. The outcomes evaluated were QTc prolongation of all grades. Statistical analysis was performed with R software version 2023.03.0+386. Results: We included 14 RCTs comprising 16,013 patients in the quantitative analysis, of whom 8,585 underwent therapy with CDK4/6i, and one more paper was included only in the qualitative analysis due to not reporting the exact number of events of QTc prolongation. An increased risk of QTc prolongation was associated with the use of CDK4/6i (RR 2.32; 95% CI 1.67–3.23; p=0.000001; I²=46%). Subgroup analyses revealed a significant increase in the QTc interval for the ribociclib and palbociclib cohorts. The ribociclib subgroup showed a risk ratio of 3.07 (RR 3.07; 95% CI 2.17-4.36; p< 0.000001; I² = 21%) while the palbociclib subgroup had a risk ratio of 1.52 (RR 1.51; 95% CI 1.05-2.16; p=0.025, I²=0%). Conclusion: Our findings suggest that QTc prolongation may be a common adverse effect of CDK4/6i, with ribociclib carrying greater risk. These results are important for guiding clinical decision-making, and further investigation is warranted to better understand the mechanisms and clinical implications of CDK4/6 i-induced QTc prolongation. Citation Format: Bruno Carvalho, Pedro Cotta Abrahão Reis, Alice Marinho, Ana Carolina Comini, Debora Xavier, Beatriz Mella S. Pessoa, Felipe Batalini. QTc prolongation as Adverse Effect of CDK4/6 inhibitors: A systematic review and meta-analysis of randomized controlled trials [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-12-08.